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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Phosphorus-based flame retardant acrylic pressure sensitive adhesives with superior peel strength and transfer characteristics | Acrylic pressure sensitive adhesives (PSAs) are widely utilized in various fields due to their excellent thermal, weather, and oil resistance. However, due to their flammability, they are vulnerable to fire, which brings a critical challenge for their application in various industries. Here, new phosphorus-based acrylic PSAs which show excellent flame retardancy are demonstrated, without sacrificing adhesion properties. By controlling the monomer composition based on five different monomers, we synthesized seven acrylic copolymers for PSAs, and investigated the correlation between monomer composition and adhesion characteristics in terms of peel strength and transfer characteristics. Among seven polymers, A5H5 which exhibits the highest peel strength (1117 gf/in.) and superior transfer characteristics (transfer area 8.30 %) is selected for further investigation. The phosphorous-based acrylic PSAs are prepared through addition of different amounts of dimethyl methylphosphonate in A5H5 polymeric matrix, and thoroughly investigated in terms of flame retardancy and adhesion characteristics in terms of peel strength and transfer characteristics. The phosphorus-based PSA (A5H5-D30) exhibited superior flame retardancy of V-0 rating under the UL-94 characterization method. Furthermore, the A5H5-D30 present excellent film transfer characteristic showing a transfer area of 0 % and residue of 0 wt% in air without massive decrease in peel strength (991 gf/in.). | Son, Myoungchan; Kim, Jinho; Oh, Myongkeon; Kim, Dongmin; Choi, Hui Ju; Lee, Kangtaek; Chung, Kyeongwoon; Lee, Sunjong | Korea Inst Ind Technol KITECH, Chungnam 31056, South Korea; Yonsei Univ, Dept Chem & Biomol Engn, Seoul 03722, South Korea; Kyungpook Natl Univ, Dept Biofibers & Biomat Sci, Daegu 41566, South Korea | Lee, Kang Taek/AHC-8558-2022 | 58570105400; 58513234400; 57205392092; 58291492600; 57222315884; 56120413000; 56416916000; 57129404900 | ktlee@yonsei.ac.kr;kychung@knu.ac.kr;sunjong1774@kitech.re.kr; | PROGRESS IN ORGANIC COATINGS | PROG ORG COAT | 0300-9440 | 1873-331X | 185 | SCIE | CHEMISTRY, APPLIED;MATERIALS SCIENCE, COATINGS & FILMS | 2023 | 6.5 | 6.5 | 1.27 | 2025-06-25 | 10 | 10 | Pressure sensitive adhesive; Acrylic adhesive; Flame retardant; Peel strength; Transfer characteristics | CROSS-LINKING; PERFORMANCE | Acrylic adhesive; Flame retardant; Peel strength; Pressure sensitive adhesive; Transfer characteristics | Acrylic monomers; Adhesion; Esters; Oil resistance; Peeling; Acrylic adhesives; Acrylic pressure-sensitive adhesives; Adhesion characteristic; Critical challenges; Flame-retardancy; Monomer compositions; Peel strength; Pressure-sensitive adhesives; Strength characteristics; Transfer characteristics; Phosphorus | English | 2023 | 2023-12 | 10.1016/j.porgcoat.2023.107931 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Steerable and Agile Light-Fueled Rolling Locomotors by Curvature-Engineered Torsional Torque | On-demand photo-steerable amphibious rolling motions are generated by the structural engineering of monolithic soft locomotors. Photo-morphogenesis of azobenzene-functionalized liquid crystal polymer networks (azo-LCNs) is designed from spiral ribbon to helicoid helices, employing a 270 & DEG; super-twisted nematic molecular geometry with aspect ratio variations of azo-LCN strips. Unlike the intermittent and biased rolling of spiral ribbon azo-LCNs with center-of-mass shifting, the axial torsional torque of helicoid azo-LCNs enables continuous and straight rolling at high rotation rates (& AP;720 rpm). Furthermore, center-tapered helicoid structures with wide edges are introduced for effectively accelerating photo-motilities while maintaining directional controllability. Irrespective of surface conditions, the photo-induced rotational torque of center-tapered helicoid azo-LCNs can be transferred to interacting surfaces, as manifested by steep slope climbing and paddle-like swimming multimodal motilities. Finally, the authors demonstrate continuous curvilinear guidance of soft locomotors, bypassing obstacles and reaching desired destinations through real-time on-demand photo-steering. | Choi, Jun-Chan; Jeon, Jisoo; Lee, Jae-Won; Nauman, Asad; Lee, Jae Gyeong; Cho, Woongbi; Lee, Chanwoo; Cho, Young-Min; Wie, Jeong Jae; Kim, Hak-Rin | Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea; Korea Inst Sci & Technol, Soft Hybrid Mat Res Ctr, Seoul 02792, South Korea; Inha Univ, Program Environm & Polymer Engn, Incheon 22212, South Korea; Hanyang Univ, Dept Organ & Nano Engn, Seoul 04763, South Korea; Hanyang Univ, Human Tech Convergence Program, Seoul 04763, South Korea; Kyungpook Natl Univ, Sch Elect Engn, Daegu 41566, South Korea; Hanyang Univ, Dept Chem Engn, Seoul 04763, South Korea; Hanyang Univ, Inst Nano Sci & Technol, Seoul 04763, South Korea; Hanyang Univ, Res Inst Ind Sci, Seoul 04763, South Korea; SUNY Syracuse, Michael M Szwarc Polymer Res Inst, Coll Environm Sci & Forestry, Syracuse, NY 13210 USA; SUNY Syracuse, Dept Chem Engn, Coll Enviromental Sci & Forestry, Syracuse, NY 13210 USA | ; Kim, Hak-Rin/T-1897-2019; Cho, Young/J-5669-2012; Cho, Woongbi/IUN-3686-2023; Wie, Jeong Jae (JJ)/I-9878-2019 | 57033068900; 57205744741; 58377059800; 57796499100; 57217492620; 57220075763; 58533098700; 58532952600; 26041261000; 7410124944 | jjwie@hanyang.ac.kr;rineey@knu.ac.kr; | ADVANCED SCIENCE | ADV SCI | 2198-3844 | 10 | 30 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY | 2023 | 14.3 | 6.5 | 1.31 | 2025-06-25 | 6 | 10 | amphibious multimodal actuation; helical soft robot; liquid crystal polymer network; on-demand steering; photo-mechanical rolling | DRIVEN | amphibious multimodal actuation; helical soft robot; liquid crystal polymer network; on-demand steering; photo-mechanical rolling | Liquid crystal polymers; Nematic liquid crystals; Amphibious multimodal actuation; Helical soft robot; Liquid crystal polymer network; Liquid-crystal polymers; Mechanical; Multi-modal; On demands; On-demand steering; Photo-mechanical rolling; Polymer networks; Soft robot; Aspect ratio | English | 2023 | 2023-10 | 10.1002/advs.202304715 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Assessment of deep learning-based image analysis for disaster waste identification | Accurately predicting different types and quantities of wastes is crucial for proper waste management and sustainable growth and development. High levels of disaster waste (DW) can negatively impact emergency re-sponses, public health, and recovery and rebuilding processes, making the effective management of DW highly important. Most existing waste identification methods cannot suitably identify DW since it is highly subjective in form. In this study, we examined the applicability of different deep learning-based image recognition techniques for DW recognition. A DW image dataset was collected and categorized into normal and hard cases. Then, ex-periments were conducted using these three network models: DeepLabV3+, ResNeSt-50, and ResNeSt-101. The experimental results indicated that the mean intersection over union (mIoU) of the DeepLabV3+ model was 0.802 for the normal case and that of the ResNeSt-101 model was 0.676 for the hard case, indicating favorable performances. Overall, the deep learning-based image analysis method is more robust than existing methods, particularly in terms of its ability to accurately identify waste in various forms, such as mixed or piled up waste. | Zhang, Yuan -Long; Kim, Young -Chan; Cha, Gi-Wook | Dongguk Univ WISE, Div Smart Safety Engn, 123 Dongdae Ro, Gyeongju 38066, South Korea; Kyungpook Natl Univ, Sch Sci & Technol Accelerat Engn, 80 Daehak Ro, Daegu 41566, South Korea | ; zhang, yuanlong/JEZ-4373-2023 | 56464271500; 56463201400; 55754413300 | yyoungchani@gmail.com; | JOURNAL OF CLEANER PRODUCTION | J CLEAN PROD | 0959-6526 | 1879-1786 | 428 | SCIE | ENGINEERING, ENVIRONMENTAL;ENVIRONMENTAL SCIENCES;GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY | 2023 | 9.8 | 6.6 | 0.4 | 2025-06-25 | 1 | 4 | Waste identification; Disaster management; Machine learning; Image recognition; Convolutional neural network | GENERATION; MANAGEMENT; EARTHQUAKE | Convolutional neural network; Disaster management; Image recognition; Machine learning; Waste identification | Deep learning; Disaster prevention; Disasters; Image analysis; Information management; Learning systems; Waste management; Convolutional neural network; Disaster management; Disaster wastes; Effective management; Emergency response; Growth and development; Image-analysis; Machine-learning; Sustainable growth; Waste identification; Image recognition | English | 2023 | 2023-11-20 | 10.1016/j.jclepro.2023.139351 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Carbon-supported vanadium nitride catalyst, prepared from urea-loaded MIL-100(V) in the absence of external ammonia flow, having good performance in oxidative desulfurization | Vanadium nitride was firstly applied to oxidative desulfurization (ODS) of liquid fuel. Carbon-supported vana-dium nitride (VN@C) was prepared from pyrolysis of urea-loaded MOF, MIL-100(V), especially in the absence of external ammonia flow. One catalyst prepared at 1100 degrees C, VN@C(1100), had the highest turnover frequency of 18.8 h- 1 (with a very low activation energy of 29.9 kJmol-1) among the reported vanadium-based catalysts. The ESR and scavenger experiments confirmed center dot OH radical was the active species for the ODS. Calculations using density functional theory could support the beneficial role of VN (compared with conventional oxides) both in the adsorption of H2O2 and center dot OH and H2O2 activation to form center dot OH radical. The VN@C(1100) catalyst could be used for five cycles without any loss in activity. Therefore, supported vanadium nitrides could be suggested as a potential catalyst for oxidations that use H2O2 as an oxidant. Moreover, supported vanadium nitrides could be facilely derived from the pyrolysis of urea-loaded V-based MOFs, without ammonia flow. | Ahmed, Imteaz; Kim, Chul-Ung; Jhung, Sung Hwa | Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Kyungpook Natl Univ, Green Nano Mat Res Ctr, Daegu 41566, South Korea; Korea Res Inst Chem Technol KRICT, Chem & Proc Technol Div, POB 107,141 Gajeong Ro, Daejeon 34114, South Korea | Jhung, Sung/AAO-6683-2021 | 55377179600; 9742142700; 6701659467 | imteaz2004@gmail.com;sung@knu.ac.kr; | JOURNAL OF CLEANER PRODUCTION | J CLEAN PROD | 0959-6526 | 1879-1786 | 384 | SCIE | ENGINEERING, ENVIRONMENTAL;ENVIRONMENTAL SCIENCES;GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY | 2023 | 9.8 | 6.6 | 1.79 | 2025-06-25 | 16 | 18 | Metal-organic frameworks; ?OH radical; Oxidative desulfurization; Pyrolysis; Vanadium nitride | METAL-ORGANIC FRAMEWORK; HIGHLY-ACTIVE CATALYST; DOPED CARBON; DIESEL FUEL; OXIDE; DENITROGENATION; TEMPERATURE; GRAPHENE; OIL | Metal-organic frameworks; Oxidative desulfurization; Pyrolysis; Vanadium nitride; •OH radical | Activation energy; Ammonia; Density functional theory; Free radicals; Hydrogen; Metabolism; Nitrides; Organometallics; Urea; Vanadium compounds; Active species; Low-activation energy; Metalorganic frameworks (MOFs); MIL-100; OH radical; Oxidative desulfurization; Performance; Turnover frequency; ]+ catalyst; •OH radical; Pyrolysis | English | 2023 | 2023-01-15 | 10.1016/j.jclepro.2022.135509 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Chemical mimetics of the N-degron pathway alleviate systemic inflammation by activating mitophagy and immunometabolic remodeling | Sepsis: chemical modulation of selective autophagy alleviates systemic inflammationSepsis is a life-threatening condition that occurs when the body's response to infection damages its own organs. Autophagy protects the body by degrading harmful materials in the cell using the lysosome. It has been an outstanding question whether autophagy can fight systemic inflammation in sepsis. Researchers in South Korea led by Eun-Kyeong Jo at Chungnam National University and Yong Tae Kwon at Seoul National University developed small molecule chemicals that target the autophagic receptor p62/SQSTSM-1/Sequestosome-1 to induce therapeutic efficacy during septic responses. In a mouse model of septic shock, these orally administrative compounds halted the production of proinflammatory molecules and reduced oxidative stress in mitochondria by facilitating the autophagic turnover of damaged mitochondria. Chemical modulation of p62 is now emerging as a therapeutic strategy to treat sepsis responsible for 11 million deaths a year. The Arg/N-degron pathway, which is involved in the degradation of proteins bearing an N-terminal signal peptide, is connected to p62/SQSTM1-mediated autophagy. However, the impact of the molecular link between the N-degron and autophagy pathways is largely unknown in the context of systemic inflammation. Here, we show that chemical mimetics of the N-degron Nt-Arg pathway (p62 ligands) decreased mortality in sepsis and inhibited pathological inflammation by activating mitophagy and immunometabolic remodeling. The p62 ligands alleviated systemic inflammation in a mouse model of lipopolysaccharide (LPS)-induced septic shock and in the cecal ligation and puncture model of sepsis. In macrophages, the p62 ligand attenuated the production of proinflammatory cytokines and chemokines in response to various innate immune stimuli. Mechanistically, the p62 ligand augmented LPS-induced mitophagy and inhibited the production of mitochondrial reactive oxygen species in macrophages. The p62 ligand-mediated anti-inflammatory, antioxidative, and mitophagy-activating effects depended on p62. In parallel, the p62 ligand significantly downregulated the LPS-induced upregulation of aerobic glycolysis and lactate production. Together, our findings demonstrate that p62 ligands play a critical role in the regulation of inflammatory responses by orchestrating mitophagy and immunometabolic remodeling. | Silwal, Prashanta; Kim, Young Jae; Lee, Yoon Jee; Kim, In Soo; Jeon, Sang Min; Roh, Taylor; Kim, Jin Kyung; Lee, Min Joung; Heo, Jun Young; Jo, Doo Sin; Lee, Sang-Hee; Cho, Dong-Hyung; Kim, Jin Man; Kwon, Yong Tae; Jo, Eun-Kyeong | Chungnam Natl Univ, Dept Microbiol, Sch Med, Daejeon 35015, South Korea; Chungnam Natl Univ, Infect Control Convergence Res Ctr, Sch Med, Daejeon 35015, South Korea; Chungnam Natl Univ, Dept Med Sci, Sch Med, Daejeon 35015, South Korea; Seoul Natl Univ, Coll Med, Cellular Degradat Biol Ctr, Seoul 03080, South Korea; Seoul Natl Univ, Coll Med, Dept Biomed Sci, Seoul 03080, South Korea; Keimyung Univ, Dept Microbiol, Sch Med, Daegu, South Korea; Chungnam Natl Univ, Dept Biochem, Sch Med, Daejeon 35015, South Korea; Kyungpook Natl Univ, Sch Life Sci, FOUR KNU Creat Biores Grp BK21, Daegu 41566, South Korea; Korea Basic Sci Inst, Bioelectron Microscopy Res Ctr 104 Dong, Ochang 28199, Cheongju, South Korea; Chungnam Natl Univ, Dept Pathol, Sch Med, Daejeon 35015, South Korea; AUTOTAC Bio Inc, Changkyunggung Ro 254, Seoul 03077, South Korea; Seoul Natl Univ, Coll Med, SNU Dementia Res Ctr, Seoul 03080, South Korea | ; Choi, Hye Rin/JDV-9065-2023; Lee, Eunhye/JJD-0686-2023; Kim, Jin Man/HJO-8987-2023; Lee, Woo/B-2195-2014; Silwal, Prashanta/AGC-8166-2022; Jeon, Sang-Min/I-7917-2018; KIM, SUNG/ADF-8559-2022 | 55662049100; 57195469752; 57188978131; 57203374975; 57217795890; 57941643200; 57214428258; 56739430300; 56692192000; 56335489800; 58743453100; 35093684400; 59291736900; 7403459177; 7003663754 | yok5@snu.ac.kr;hayoungj@cnu.ac.kr; | EXPERIMENTAL AND MOLECULAR MEDICINE | EXP MOL MED | 1226-3613 | 2092-6413 | 55 | 2 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL | 2023 | 9.5 | 6.6 | 1.05 | 2025-06-25 | 10 | 7 | END RULE PATHWAY; AMINO-TERMINAL ARGINYLATION; AUTOPHAGY; SEPSIS; INTERLEUKIN-18; DEGRADATION; INFECTION; SIGNAL; CELL | Animals; Autophagy; Inflammation; Ligands; Lipopolysaccharides; Mice; Mitophagy; Sepsis; cryopyrin; lactic acid; lipopolysaccharide; sequestosome 1; ligand; lipopolysaccharide; aerobic glycolysis; animal cell; animal experiment; animal tissue; Article; biomimetics; cecal ligation and puncture-induced sepsis; controlled study; cytokine production; cytokine response; down regulation; glycolysis; immune response; in vitro study; in vivo study; inflammation; innate immunity; ligand binding; metabolic disorder; mitophagy; mouse; nonhuman; protein function; septic shock; signal transduction; survival rate; upregulation; animal; autophagy; inflammation; sepsis | English | 2023 | 2023-02 | 10.1038/s12276-023-00929-x | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Meeting Abstract | Deep Learning vs. Handcrafted Radiomics to Predict Chemoradiotherapy Response for Locally Advanced Cervical Cancer | Park, S. H.; Jeong, S.; Yu, H.; Woo, D.; Chong, G. O.; Han, H. S.; Kim, J. | Kyungpook Natl Univ, Sch Med, Dept Radiat Oncol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Med Informat, Daegu, South Korea; Kyungpook Natl Univ Hosp, Res Ctr Artificial Intelligence Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Obstet & Gynecol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Clin Omics Res Ctr, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Physiol, Daegu, South Korea | INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | INT J RADIAT ONCOL | 0360-3016 | 1879-355X | 117 | 2 | SCIE | ONCOLOGY;RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | 2023 | 6.4 | 6.6 | 0 | English | 2023 | 2023-10-01 | 바로가기 | 바로가기 | ||||||||||||||||
| ○ | ○ | Article | Enhancement of the SESN2-SHP cascade by melatonin ameliorates hepatic gluconeogenesis by inhibiting the CRBN-BTG2-CREBH signaling pathway | Melatonin is involved in the regulation of various biological functions. Here, we explored a novel molecular mechanism by which the melatonin-induced sestrin2 (SESN2)-small heterodimer partner (SHP) signaling pathway protects against fasting- and diabetes-mediated hepatic glucose metabolism. Various key gene expression analyses were performed and multiple metabolic changes were assessed in liver specimens and primary hepatocytes of mice and human participants. The expression of the hepatic cereblon (CRBN) and b-cell translocation gene 2 (BTG2) genes was significantly increased in fasting mice, diabetic mice, and patients with diabetes. Overexpression of Crbn and Btg2 increased hepatic gluconeogenesis by enhancing cyclic adenosine monophosphate (cAMP)-responsive element-binding protein H (CREBH), whereas this phenomenon was prominently ablated in Crbn null mice and Btg2-silenced mice. Interestingly, melatonin-induced SESN2 and SHP markedly reduced hepatic glucose metabolism in diabetic mice and primary hepatocytes, and this protective effect of melatonin was strikingly reversed by silencing Sesn2 and Shp. Finally, the melatonin-induced SESN2-SHP signaling pathway inhibited CRBN- and BTG2-mediated hepatic gluconeogenic gene transcription via the competition of BTG2 and the interaction of CREBH. Mitigation of the CRBN-BTG2-CREBH axis by the melatonin-SESN2-SHP signaling network may provide a novel therapeutic strategy to treat metabolic dysfunction due to diabetes. Diabetes: Signalling pathway interactions regulated by melatoninThe identification of a fundamental signalling process regulated by melatonin that can prevent excessive liver glucose metabolism during diabetes may offer a novel therapeutic approach. Both fasting and diabetic states trigger the elevation of a particular signalling pathway that significantly increases liver glucose metabolism, or 'hepatic gluconeogenesis', resulting in a rise in blood sugar levels. In experiments on mouse models and human patients, Yong Deuk Kim at Kyungpook National University in Daegu, South Korea, and co-workers have demonstrated that the hormone melatonin plays a vital role in suppressing hepatic gluconeogenesis. Melatonin upregulates another signaling cascade involving a stress regulation protein called sestrin-2 and its associated regulatory protein, SHP. The upregulation of SHP by melatonin repressed genes that are involved in gluconeogenesis, both in diabetic mice and in the human liver. | An, Seungwon; Nedumaran, Balachandar; Koh, Hong; Joo, Dong Jin; Lee, Hyungjo; Park, Chul-Seung; Harris, Robert A.; Shin, Keong Sub; Djalilian, Ali R.; Kim, Yong Deuk | Univ Illinois, Dept Ophthalmol & Visual Sci, Chicago, IL 60612 USA; Univ Colorado, Barbara Davis Ctr Diabet, Sch Med, Anschutz Med Campus, Aurora, CO 80045 USA; Yonsei Univ, Dept Pediat, Div Gastroenterol Hepatol & Nutr, Severance Childrens Hosp,Severance Pediat Liver Di, Seoul 03722, South Korea; Yonsei Univ, Dept Surg, Coll Med, Seoul 03722, South Korea; Gwangju Inst Sci & Technol, Sch Life Sci, Gwangju 61005, South Korea; Gwangju Inst Sci & Technol, Cell Logist Res Ctr, Gwangju 61005, South Korea; Indiana Univ Sch Med, Dept Biochem & Mol Biol, Indianapolis, IN 46202 USA; DUKSAN Inst Biomed & Life Sci, Gwangmyeong 14348, South Korea; Young Sci Inc, Bucheon 14449, South Korea; Kyungpook Natl Univ, Res Inst Aging & Metab, Daegu 41566, South Korea | Nedumaran, Balachandar/V-9958-2019 | 57208273554; 23976497500; 35789948700; 57216087775; 57930061600; 57198831126; 35430442700; 58499398900; 6603043343; 55549957700 | ydkim94@gmail.com; | EXPERIMENTAL AND MOLECULAR MEDICINE | EXP MOL MED | 1226-3613 | 2092-6413 | 55 | 7 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL | 2023 | 9.5 | 6.6 | 0.9 | 2025-06-25 | 5 | 6 | TRANSCRIPTION FACTOR; INDUCTION; CEREBLON; PROTEIN; DISRUPTION; EXPRESSION; RECEPTORS | Adaptor Proteins, Signal Transducing; Animals; Diabetes Mellitus, Experimental; Gluconeogenesis; Glucose; Humans; Immediate-Early Proteins; Liver; Melatonin; Mice; Mice, Inbred C57BL; Sestrins; Signal Transduction; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases; cyclic AMP responsive element binding protein; melatonin; peptides and proteins; protein CREBH; sestrin; sestrin 2; small heterodimer partner; unclassified drug; BTG2 protein, human; CRBN protein, human; glucose; immediate early protein; melatonin; SESN2 protein, human; sestrin; signal transducing adaptor protein; tumor suppressor protein; ubiquitin protein ligase; animal cell; animal experiment; animal model; Article; Btg2 gene; controlled study; Crbn gene; diabetes mellitus; fasting; gene; gene expression; genetic transcription; gluconeogenesis; glucose metabolism; human; human cell; human tissue; liver cell; liver disease; liver metabolism; male; mouse; nonhuman; Sesn2 gene; Shp gene; signal transduction; animal; C57BL mouse; experimental diabetes mellitus; genetics; liver; metabolism; physiology | English | 2023 | 2023-07 | 10.1038/s12276-023-01040-x | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Epigenetic regulation of SMAD3 by histone methyltransferase SMYD2 promotes lung cancer metastasis | Lung cancer: An opportunity to prevent cancer spreadA protein that accelerates cancer spread (metastasis) could be an effective target for novel therapies for non-small-cell lung cancer (NSCLC), which generally has a poor prognosis. Increased activity of the SMYD2 protein is associated with more aggressive growth in several cancer types, and Kwangho Kim of the Korea Research Institute of Bioscience and Biotechnology, Daejeon, and colleagues have linked heightened SMYD2 expression with poor prognosis in NSCLC patients. Experiments with cultured lung cancer cells demonstrated that SMYD2 plays a role in epithelial-mesenchymal transition, a cellular transformation process that leads to metastatic growth. Interventions that disrupt SMYD2 production in tumor cells hindered this process. Mice transplanted with SMYD2-deficient cells were significantly less prone to metastases than animals receiving cells with unimpeded SMYD2 production. These findings could present a therapeutic approach for this form of lung cancer. Epigenetic alterations, especially histone methylation, are key factors in cell migration and invasion in cancer metastasis. However, in lung cancer metastasis, the mechanism by which histone methylation regulates metastasis has not been fully elucidated. Here, we found that the histone methyltransferase SMYD2 is overexpressed in lung cancer and that knockdown of SMYD2 could reduce the rates of cell migration and invasion in lung cancer cell lines via direct downregulation of SMAD3 via SMYD2-mediated epigenetic regulation. Furthermore, using an in vitro epithelial-mesenchymal transition (EMT) system with a Transwell system, we generated highly invasive H1299 (In-H1299) cell lines and observed the suppression of metastatic features by SMYD2 knockdown. Finally, two types of in vivo studies revealed that the formation of metastatic tumors by shSMYD2 was significantly suppressed. Thus, we suggest that SMYD2 is a potential metastasis regulator and that the development of SMYD2-specific inhibitors may help to increase the efficacy of lung cancer treatment. | Kim, Kwangho; Ryu, Tae Young; Jung, Eunsun; Han, Tae-Su; Lee, Jinkwon; Kim, Seon-Kyu; Roh, Yu Na; Lee, Moo-Seung; Jung, Cho-Rok; Lim, Jung Hwa; Hamamoto, Ryuji; Lee, Hye Won; Hur, Keun; Son, Mi-Young; Kim, Dae-Soo; Cho, Hyun-Soo | Korea Res Inst Biosci & Biotechnol, Daejeon, South Korea; Chungnam Natl Univ, Coll Pharm, Daejeon, South Korea; Korea Univ Sci & Technol, Dept Funct Genom, Daejeon, South Korea; Sungkyunkwan Univ, Dept Biol Sci, Suwon, South Korea; Natl Canc Ctr, Div Mol Modificat & Canc Biol, Tokyo, Japan; Keimyung Univ, Sch Med, Dept Pathol, Daegu, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biochem & Cell Biol, Daegu, South Korea | Kim, Seon-Kyu/KBA-0395-2024; Hamamoto, Ryuji/AAF-9600-2019; Lee, Jinkwon/L-7826-2015; Hur, Keun/G-9513-2011; Kim, Young Hoon/F-5424-2012 | 57200561661; 57204715311; 57205182220; 26424339800; 57226003200; 13410554000; 57988609400; 55626176100; 57194011220; 36523358200; 6701794416; 57907713300; 8861888000; 7004301289; 8056858000; 56508722000 | KeunHur@knu.ac.kr;myson@kribb.re.kr;kds2465@kribb.re.kr;chohs@kribb.re.kr; | EXPERIMENTAL AND MOLECULAR MEDICINE | EXP MOL MED | 1226-3613 | 2092-6413 | 55 | 5 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL | 2023 | 9.5 | 6.6 | 2.71 | 2025-06-25 | 18 | 18 | EPITHELIAL-MESENCHYMAL TRANSITION; METHYLATION; EXPRESSION; ADENOCARCINOMA; PROGRESSION; INHIBITOR; PATHWAY | Cell Line, Tumor; Cell Proliferation; Epigenesis, Genetic; Epithelial-Mesenchymal Transition; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lung Neoplasms; Smad3 Protein; histone methyltransferase; histone methyltransferase SMYD2; Smad3 protein; unclassified drug; histone; histone lysine methyltransferase; histone methyltransferase; Smad3 protein; SMAD3 protein, human; SMYD2 protein, human; animal experiment; animal model; animal tissue; Article; cell invasion; cell migration; controlled study; epigenetics; epithelial mesenchymal transition; female; human; human cell; in vitro study; lung metastasis; mouse; NCI-H1299 cell line; NCI-H1703 cell line; NOD SCID mouse; nonhuman; protein expression; transwell assay; cell proliferation; genetic epigenesis; genetics; lung tumor; metabolism; tumor cell line | English | 2023 | 2023-05 | 10.1038/s12276-023-00987-1 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Review | Grave-to-cradle: human embryonic lineage tracing from the postmortem body | Curiosity concerning the process of human creation has been around for a long time. Relevant questions seemed to be resolved with the knowledge of how cells divide after fertilization obtained through in vitro fertilization experiments. However, we still do not know how human life is created at the cellular level. Recently, the value of cadavers as a resource from which to obtain "normal " cells and tissues has been established, and human research using postmortem bodies has attracted growing scientific attention. As the human genome can be analyzed at the level of nucleotides through whole-genome sequencing, individual cells in a postmortem body can be traced back to determine what developmental processes have transpired from fertilization. These retrospective lineage tracing studies have answered several unsolved questions on how humans are created. This review covers the methodologies utilized in lineage tracing research in a historical context and the conceptual basis for reconstructing the division history of cells in a retrospective manner using postzygotic somatic variants in postmortem tissue. We further highlight answers that postmortem research could potentially address and discuss issues that wait to be solved in the future. | Choi, Seock Hwan; Ku, Eu Jeong; Choi, Yujin Angelina; Oh, Ji Won | Kyungpook Natl Univ, Sch Med, Dept Urol, Daegu, South Korea; Kyungpook Natl Univ Hosp, Biomed Res Inst, Daegu, South Korea; Chungbuk Natl Univ Hosp, Dept Internal Med, Coll Med, Cheongju, South Korea; Chungbuk Natl Univ, Coll Med, Cheongju, South Korea; Yonsei Univ, Dept Anat, Coll Med, Seoul, South Korea; Yonsei Univ, Brain Korea 21 PLUS Project Med Sci, Coll Med, Seoul, South Korea | ; Ku, Eu Jeong/MEO-0856-2025; Oh, Ji/AAZ-3153-2020 | 9742645500; 56511635600; 59153721700; 36093206200 | G1@yuhs.ac; | EXPERIMENTAL AND MOLECULAR MEDICINE | EXP MOL MED | 1226-3613 | 2092-6413 | 55 | 1 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL | 2023 | 9.5 | 6.6 | 0.13 | 2025-06-25 | 2 | 2 | ADULT STEM-CELLS; SOMATIC MUTATIONS; INTRATUMOR HETEROGENEITY; L1 RETROTRANSPOSITION; EVOLUTION; MOSAICISM; DYNAMICS; ACCUMULATION; NEMATODE; HEALTHY | Cell Lineage; Fertilization in Vitro; Humans; Retrospective Studies; apoptosis; autopsy; cadaver; Caenorhabditis elegans; cell differentiation; cell division; cell fate; cell population; chromosome 17; embryo cell; embryo development; genetic variability; genotype; hematopoiesis; human; in vitro fertilization; in vitro study; in vivo study; induced pluripotent stem cell; inner cell mass; keratinocyte; laser capture microdissection; nonhuman; phylogenetic tree; postmortem interval; primordial germ cell; Review; somatic mutation; somatic variant; stem cell; transcriptomics; trophectoderm; whole genome sequencing; cell lineage; genetics; in vitro fertilization; retrospective study | English | 2023 | 2023-01 | 10.1038/s12276-022-00912-y | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Inhibition of mitochondrial phosphate carrier prevents high phosphate-induced superoxide generation and vascular calcification | Vascular disease: Phosphate transport protein implicated in blood vessel stiffeningDrugs that block the transport of phosphate ions into mitochondria, the 'powerhouses' of the cell, could prevent life-threatening stiffening of blood vessel walls. Using smooth muscle cells taken from rat aortas, Kyu-Sang Park of Yonsei University Wonju College of Medicine, South Korea, and colleagues showed how mitochondrial uptake of phosphate via phosphate transport proteins triggered toxic metabolite generation, increased activity of bone formation genes and other reactions that collectively drive the deposition of minerals, leading to vascular stiffening. Suppression of the proteins' activity, either using drug-like compounds or by genetic means, reduced these pathological changes in mice. The findings highlight the therapeutic potential of such an approach in people with elevated serum phosphate leading to calcium build-up within their vessel walls, a major risk factor for cardiovascular disease. Vascular calcification is a serious complication of hyperphosphatemia that causes cardiovascular morbidity and mortality. Previous studies have reported that plasmalemmal phosphate (Pi) transporters, such as PiT-1/2, mediate depolarization, Ca2+ influx, oxidative stress, and calcific changes in vascular smooth muscle cells (VSMCs). However, the pathogenic mechanism of mitochondrial Pi uptake in vascular calcification associated with hyperphosphatemia has not been elucidated. We demonstrated that the phosphate carrier (PiC) is the dominant mitochondrial Pi transporter responsible for high Pi-induced superoxide generation, osteogenic gene upregulation, and calcific changes in primary VSMCs isolated from rat aortas. Notably, acute incubation with high Pi markedly increased the protein abundance of PiC via ERK1/2- and mTOR-dependent translational upregulation. Genetic suppression of PiC prevented Pi-induced ERK1/2 activation, superoxide production, osteogenic differentiation, and vascular calcification of VSMCs in vitro and aortic rings ex vivo. Pharmacological inhibition of mitochondrial Pi transport using butyl malonate (BMA) or mersalyl abolished all pathologic changes involved in high Pi-induced vascular calcification. BMA or mersalyl also effectively prevented osteogenic gene upregulation and calcification of aortas from 5/6 subtotal nephrectomized mice fed a high-Pi diet. Our results suggest that mitochondrial Pi uptake via PiC is a critical molecular mechanism mediating mitochondrial superoxide generation and pathogenic calcific changes, which could be a novel therapeutic target for treating vascular calcification associated with hyperphosphatemia. | Nguyen, Nhung Thi; Nguyen, Tuyet Thi; Nguyen, Ha Thu; Lee, Ji-Min; Kim, Min-Ji; Qi, Xu-Feng; Cha, Seung-Kuy; Lee, In-Kyu; Park, Kyu-Sang | Yonsei Univ Wonju, Dept Physiol, Coll Med, Wonju, South Korea; Yonsei Univ, Mitohormesis Res Ctr, Wonju Coll Med, Wonju, South Korea; VinUniversity, Coll Hlth Sci, Med Doctor Program, Hanoi, Vietnam; VinUniversity, Internal Med Residency Program, Hanoi, Vietnam; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Jinan Univ, Dept Dev & Regenerat Biol, Key Lab Regenerat Med, Minist Educ, Guangzhou, Peoples R China | Cha, Seung-Kuy/ABA-9147-2022; Lee, Ji Min/KCZ-2783-2024; Kim, Min-Ji/Z-5205-2019; Lee, In-Kyu/AAR-6374-2021 | 58120615200; 59031543800; 58120366600; 57211862625; 57206189095; 26649583200; 56517534100; 36071537600; 7408066837 | tuyet.nt@vinuni.edu.vn;leei@knu.ac.kr;qsang@yonsei.ac.kr; | EXPERIMENTAL AND MOLECULAR MEDICINE | EXP MOL MED | 1226-3613 | 2092-6413 | 55 | 3 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL | 2023 | 9.5 | 6.6 | 1.51 | 2025-06-25 | 11 | 10 | OXIDATIVE STRESS; INORGANIC-PHOSPHATE; IN-VITRO; EXPRESSION; APOPTOSIS; IDENTIFICATION; TRANSPORTER; METABOLISM; CALCIUM; ROLES | Animals; Cells, Cultured; Hyperphosphatemia; Mersalyl; Mice; Myocytes, Smooth Muscle; Osteogenesis; Phosphate Transport Proteins; Phosphates; Rats; Superoxides; Vascular Calcification; malonic acid; mammalian target of rapamycin; mersalyl; mitogen activated protein kinase 1; mitogen activated protein kinase 3; phosphate; phosphate transporter; reactive oxygen metabolite; superoxide; phosphate; phosphate transporter; superoxide; animal cell; animal experiment; animal model; animal tissue; aortic ring (slice); Article; blood vessel calcification; cell differentiation; cell isolation; chronic kidney failure; controlled study; disease association; enzyme activation; ex vivo study; gene repression; gene silencing; hyperphosphatemia; intracellular signaling; male; mitochondrion; mouse; nephrectomy; nonhuman; osteoblast; oxidative stress; pharmacological blocking; phosphate transport; rat; translation regulation; upregulation; vascular smooth muscle cell; animal; blood vessel calcification; bone development; cell culture; complication; genetics; hyperphosphatemia; metabolism; pathology; smooth muscle cell | English | 2023 | 2023-03 | 10.1038/s12276-023-00950-0 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Insulin signaling is critical for sinoatrial node maintenance and function | Insulin signaling: A role in controlling heart rateThe hormone insulin and the related protein insulin-like growth factor-1 (IGF-1) have previously unrecognized significance in regulating heart rate through cell signaling activities affecting the pacemaker region of the heart. Researchers in South Korea led by Wang-Soo Lee and Jaetaek Kim at Chung-Ang University, Seoul, investigated the role of receptor proteins that bind to insulin and IGF-1 in the heart's pacemaker sinoatrial node in mice. They explored the effects of genetic interventions altering the normal levels of these receptor proteins, revealing a critical role for insulin and IGF-1 in sinoatrial node function. The results could suggest new approaches to treating sinus node dysfunction (SND), also known as sick sinus syndrome. SND is associated with increased risk of fainting, atrial fibrillation and heart failure, especially in elderly or overweight people. Insulin and insulin-like growth factor 1 (IGF-1) signaling regulate cellular growth and glucose metabolism in the myocardium. However, their physiological role in the cells of the cardiac conduction system has never been explored. Therefore, we sought to determine the spatiotemporal function of insulin/IGF-1 receptors in the sinoatrial node (SAN). We generated cardiac conduction cell-specific inducible IGF-1 receptor (IGF-1R) knockout (KO) (CSIGF1RKO), insulin receptor (IR) KO (CSIRKO), and IR/IGF-1R double-KO (CSDIRKO) mice and evaluated their phenotypes. Telemetric electrocardiography revealed regular sinus rhythm in CSIGF1RKO mice, indicating that IGF-1R is dispensable for normal pacemaking. In contrast, CSIRKO and CSDIRKO mice exhibited profound sinus bradycardia. CSDIRKO mice showed typical sinus node dysfunction characterized by junctional rhythm and sinus pauses on electrocardiography. Interestingly, the lack of an insulin receptor in the SAN cells of CSIRKO and CSDIRKO mice caused sinus nodal fibrosis. Mechanistically, hyperpolarization-activated cyclic nucleotide-gated channel 4 (HCN4) protein expression significantly decreased in the CSIRKO and CSDIRKO mice relative to the controls. A patch-clamp study of the SAN cells of CSIRKO mice revealed a significant decrease in the funny current, which is responsible for spontaneous diastolic depolarization in the SAN. This result suggested that insulin receptor loss reduces the heart rate via downregulation of the HCN4 channel. Additionally, HCN1 expression was decreased in CSDIRKO mice, explaining their sinus node dysfunction. Our results reveal a previously unrecognized role of insulin/IGF-1 signaling in sinus node structural maintenance and pacemaker function. | Ock, Sangmi; Choi, Seong Woo; Choi, Seung Hee; Kang, Hyun; Kim, Sung Joon; Lee, Wang-Soo; Kim, Jaetaek | Chung Ang Univ, Coll Med, Dept Internal Med, Div Endocrinol & Metab, Seoul, South Korea; Seoul Natl Univ, Coll Med, Dept Physiol & Biomed Sci, Seoul, South Korea; Dongguk Univ, Dept Physiol, Coll Med, Gyeongju, South Korea; Kyungpook Natl Univ, Dept Internal Med, Div Endocrinol & Metab, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Dept Biochem & Cell Biol, Div Endocrinol & Metab, Sch Med, Daegu, South Korea; Chung Ang Univ, Coll Med, Dept Anesthesiol, Seoul, South Korea; Chung Ang Univ, Coll Med, Dept Internal Med, Div Cardiol, Seoul, South Korea | ; Lee, Wang-Soo/AAS-1477-2021; Kim, Sung/H-1825-2012 | 54796821100; 55601865600; 58112613300; 36126616500; 7409930855; 27967755500; 57210199984 | wslee1227@cau.ac.kr;jtkim@cau.ac.kr; | EXPERIMENTAL AND MOLECULAR MEDICINE | EXP MOL MED | 1226-3613 | 2092-6413 | 55 | 5 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL | 2023 | 9.5 | 6.6 | 0.6 | 2025-06-25 | 5 | 4 | SICK SINUS SYNDROME; RECEPTOR; DYSFUNCTION; DELETION; ATRIAL; CARDIOMYOCYTES; BRADYCARDIA; THYROCYTES; EXPRESSION; MORTALITY | Animals; Insulin; Insulin-Like Growth Factor I; Mice; Receptor, Insulin; Sick Sinus Syndrome; Sinoatrial Node; collagen type 1; collagen type 3; gelatinase A; hyperpolarization activated cyclic nucleotide gated channel; insulin; insulin receptor; somatomedin C; somatomedin C receptor; insulin; insulin receptor; somatomedin C; actc1 gene; animal cell; animal experiment; animal model; animal tissue; Article; atrioventricular junction arrhythmia; C57BL 6 mouse; cardiac muscle cell; controlled study; ctnt gene; down regulation; electrocardiography; fibrosis; gene deletion; heart conduction; heart rate; histology; immunohistochemistry; insulin signaling; knockout mouse; male; marker gene; mouse; newborn; nonhuman; patch clamp technique; protein expression; real time reverse transcription polymerase chain reaction; RNA isolation; sinus node; sinus node disease; telemetry; Western blotting; wild type mouse; animal; metabolism; sick sinus syndrome | English | 2023 | 2023-05 | 10.1038/s12276-023-00988-0 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Review | Mitochondria-associated programmed cell death as a therapeutic target for age-related disease | Mitochondria, ubiquitous double-membrane-bound organelles, regulate energy production, support cellular activities, harbor metabolic pathways, and, paradoxically, mediate cell fate. Evidence has shown mitochondria as points of convergence for diverse cell death-inducing pathways that trigger the various mechanisms underlying apoptotic and nonapoptotic programmed cell death. Thus, dysfunctional cellular pathways eventually lead or contribute to various age-related diseases, such as neurodegenerative, cardiovascular and metabolic diseases. Thus, mitochondrion-associated programmed cell death-based treatments show great therapeutic potential, providing novel insights in clinical trials. This review discusses mitochondrial quality control networks with activity triggered by stimuli and that maintain cellular homeostasis via mitohormesis, the mitochondrial unfolded protein response, and mitophagy. The review also presents details on various forms of mitochondria-associated programmed cell death, including apoptosis, necroptosis, ferroptosis, pyroptosis, parthanatos, and paraptosis, and highlights their involvement in age-related disease pathogenesis, collectively suggesting therapeutic directions for further research. | Thanh T Nguyen; Wei, Shibo; Thu Ha Nguyen; Jo, Yunju; Zhang, Yan; Park, Wonyoung; Gariani, Karim; Oh, Chang-Myung; Kim, Hyeon Ho; Ha, Ki-Tae; Park, Kyu Sang; Park, Raekil; Lee, In-Kyu; Shong, Minho; Houtkooper, Riekelt H.; Ryu, Dongryeol | Gwangju Inst Sci & Technol GIST, Dept Biomed Sci & Engn, Gwangju 61005, South Korea; Sungkyunkwan Univ, Dept Precis Med, Sch Med, Suwon 16419, South Korea; Yonsei Univ, Dept Physiol, Wonju Coll Med, Wonju 26426, South Korea; Sungkyunkwan Univ, Dept Mol Cell Biol, Sch Med, Suwon 16419, South Korea; Pusan Natl Univ, Sch Korean Med, Dept Korean Med Sci, Yangsan 50612, South Korea; Geneva Univ Hosp, Serv Endocrinol Diabet Nutr & Patient Therapeut E, CH-1205 Geneva, Switzerland; Sungkyunkwan Univ, Samsung Adv Inst Hlth Sci & Technol, Dept Hlth Sci & Technol, Seoul 06351, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu 41944, South Korea; Chungnam Natl Univ, Dept Internal Med, Sch Med, Daejeon 35015, South Korea; Amsterdam UMC Locat Univ Amsterdam, Lab Genet Metab Dis, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands; Amsterdam UMC Locat Univ Amsterdam, Amsterdam Gastroenterol Endocrinol & Metab, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands; Amsterdam UMC Locat Univ Amsterdam, Amsterdam Cardiovasc Sci, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands | ; Nguyen, Thanh-Tin/S-3585-2019; Houtkooper, Riekelt/P-5001-2019; Jo, Yunju/KII-0253-2024; Kitae, Ha/AFW-2347-2022; Lee, In-Kyu/AAR-6374-2021; Park, Raekil/NOF-3549-2025; Wei, Shibo/LSJ-6718-2024; Ryu, Dongryeol/AAQ-3642-2020 | 56683599100; 58175728900; 58596338000; 57206376774; 58045260300; 57614765800; 26657263700; 14830413900; 57206210460; 7102262033; 7408066837; 7401895726; 36071537600; 7003976276; 6507644060; 57201809600 | r.h.houtkooper@amsterdamumc.nl;dryu@gist.ac.kr; | EXPERIMENTAL AND MOLECULAR MEDICINE | EXP MOL MED | 1226-3613 | 2092-6413 | 55 | 8 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL | 2023 | 9.5 | 6.6 | 7.89 | 2025-06-25 | 136 | 136 | STRESS-RESPONSE; APOPTOSIS; INFLAMMATION; NECROPTOSIS; HOMEOSTASIS; MECHANISMS; MITOPHAGY; CALCIUM; BAX | Apoptosis; Cell Death; Mitochondria; Pyroptosis; cytokine; mitokine; programmed death 1 receptor; unclassified drug; apoptosis; brain depth stimulation; cardiovascular disease; cell structure; degenerative disease; ferroptosis; human; incidence; malignant neoplasm; metabolic disorder; mitochondrion; mitohormesis; mitophagy; molecular dynamics; necroptosis; nonhuman; paraptosis; parthanatos; protein unfolding; pyroptosis; quality control; Review; cell death; mitochondrion | English | 2023 | 2023-08 | 10.1038/s12276-023-01046-5 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Natural overexpression of CAROTENOID CLEAVAGE DIOXYGENASE 4 in tomato alters carotenoid flux | Carotenoids and apocarotenoids function as pigments and flavor volatiles in plants that enhance consumer appeal and offer health benefits. Tomato (Solanum lycopersicum.) fruit, especially those of wild species, exhibit a high degree of natural variation in carotenoid and apocarotenoid contents. Using positional cloning and an introgression line (IL) of Solanum habrochaites "LA1777', IL8A, we identified carotenoid cleavage dioxygenase 4 (CCD4) as the factor responsible for controlling the dark orange fruit color. CCD4b expression in ripe fruit of IL8A plants was similar to 8,000 times greater than that in the wild type, presumably due to 5 ' cis-regulatory changes. The ShCCD4b-GFP fusion protein localized in the plastid. Phytoene, zeta-carotene, and neurosporene levels increased in ShCCD4b-overexpressing ripe fruit, whereas trans-lycopene, beta-carotene, and lutein levels were reduced, suggestive of feedback regulation in the carotenoid pathway by an unknown apocarotenoid. Solid-phase microextraction-gas chromatography-mass spectrometry analysis showed increased levels of geranylacetone and beta-ionone in ShCCD4b-overexpressing ripe fruit coupled with a beta-cyclocitral deficiency. In carotenoid-accumulating Escherichia coli strains, ShCCD4b cleaved both zeta-carotene and beta-carotene at the C9-C10 (C9 '-C10 ') positions to produce geranylacetone and beta-ionone, respectively. Exogenous beta-cyclocitral decreased carotenoid synthesis in the ripening fruit of tomato and pepper (Capsicum annuum), suggesting feedback inhibition in the pathway. Our findings will be helpful for enhancing the aesthetic and nutritional value of tomato and for understanding the complex regulatory mechanisms of carotenoid and apocarotenoid biogenesis. CAROTENOID CLEAVAGE DIOXYGENASE 4b cleaves zeta-carotene and beta-carotene, and its overexpression leads to beta-cyclocitral deficiency in tomato fruit. | Yoo, Hee Ju; Chung, Mi-Young; Lee, Hyun-Ah; Lee, Soo-Bin; Grandillo, Silvana; Giovannoni, James J.; Lee, Je Min | Kyungpook Natl Univ, Dept Hort Sci, Daegu 41566, South Korea; Sunchon Natl Univ, Dept Agr Educ, Sunchon 57922, South Korea; Yonam Coll, Div Ecofriendly Hort, Cheonan 31005, South Korea; Inst Biosci & Bioresources IBBR, CNR, Via Univ 133, I-80055 Portici, Italy; Boyce Thompson Inst Plant Res, Cornell Univ Campus,Tower Rd, Ithaca, NY 14853 USA; USDA ARS, Robert W Holley Ctr, Tower Rd,Cornell Univ Campus, Ithaca, NY 14853 USA | ; Lee, Je Min/F-9797-2014; Giovannoni, James J./LTE-4376-2024; Lee, Je/AAE-7496-2020 | 56103898300; 24821361600; 57192499500; 57215038599; 6602762164; 7003348202; 8885729900 | jemin@knu.ac.kr; | PLANT PHYSIOLOGY | PLANT PHYSIOL | 0032-0889 | 1532-2548 | 192 | 2 | SCIE | PLANT SCIENCES | 2023 | 6.6 | 6.6 | 2.5 | 2025-06-25 | 16 | 18 | BETA-IONONE; FUNCTIONAL-CHARACTERIZATION; AGROBACTERIUM-TUMEFACIENS; LYCOPENE CYCLASE; PLANT TOLERANCE; CROCUS-SATIVUS; GENE; IDENTIFICATION; BIOSYNTHESIS; FLAVOR | beta Carotene; Carotenoids; Dioxygenases; Fruit; Solanum lycopersicum; zeta Carotene; beta carotene; beta-cyclocitral; beta-ionone; carotenoid; dioxygenase; geranylacetone; zeta carotene; fruit; genetics; metabolism; tomato | English | 2023 | 2023-05-01 | 10.1093/plphys/kiad049 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Review | Peptides as multifunctional players in cancer therapy | Peptides exhibit lower affinity and a shorter half-life in the body than antibodies. Conversely, peptides demonstrate higher efficiency in tissue penetration and cell internalization than antibodies. Regardless of the pros and cons of peptides, they have been used as tumor-homing ligands for delivering carriers (such as nanoparticles, extracellular vesicles, and cells) and cargoes (such as cytotoxic peptides and radioisotopes) to tumors. Additionally, tumor-homing peptides have been conjugated with cargoes such as small-molecule or chemotherapeutic drugs via linkers to synthesize peptide-drug conjugates. In addition, peptides selectively bind to cell surface receptors and proteins, such as immune checkpoints, receptor kinases, and hormone receptors, subsequently blocking their biological activity or serving as hormone analogs. Furthermore, peptides internalized into cells bind to intracellular proteins and interfere with protein-protein interactions. Thus, peptides demonstrate great application potential as multifunctional players in cancer therapy. Cancer treatment: peptides offer options for targeted therapeutic deliveryTargeted drug delivery systems using tiny, non-toxic guiding molecules could transform cancer treatment and reduce chemotherapy resistance. Peptides are small molecules consisting of two or more amino acids. While they degrade quickly in the body, they show promise as guiding molecules for targeted drug delivery, with deep tissue penetration and low toxicity. Byungheon Lee at Kyungpook National University in Daegu, South Korea, and co-workers reviewed progress into novel therapeutic systems that use 'tumour-homing' peptides to target solid tumours. Adding peptides to nanoparticles that carry chemotherapy drugs enhances their penetration and accumulation in target tumours. Peptide-assisted delivery can also reduce the major adverse effects of chemotherapy, and appear to be widely tolerated in the body, even in the brain. Peptides that bind to and inhibit surface receptor proteins on tumour cells could also block cancer progression. | Vadevoo, Sri Murugan Poongkavithai; Gurung, Smriti; Lee, Hyun-Su; Gunassekaran, Gowri Rangaswamy; Lee, Seok-Min; Yoon, Jae-Won; Lee, Yun-Ki; Lee, Byungheon | Kyungpook Natl Univ, Dept Biochem & Cell Biol, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Dept Biomed Sci, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, Sch Med, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Daegu Catholic Univ, Dept Physiol, Sch Med, 33 Duryugongwon Ro 17 Gil, Daegu 42472, South Korea | 56663280000; 57205752137; 57272028400; 36028043400; 58297098600; 58297981800; 57211232298; 16304374900 | leebh@knu.ac.kr; | EXPERIMENTAL AND MOLECULAR MEDICINE | EXP MOL MED | 1226-3613 | 2092-6413 | 55 | 6 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL | 2023 | 9.5 | 6.6 | 5.68 | 2025-06-25 | 85 | 94 | EPIDERMAL-GROWTH-FACTOR; PRO-APOPTOTIC PEPTIDE; HUMAN-LUNG-CANCER; C-MYC ONCOGENE; ANTITUMOR-ACTIVITY; IN-VITRO; INTERLEUKIN-4 RECEPTOR; TARGETED DELIVERY; TUMOR-CELLS; PROTEIN-INTERACTION | Antineoplastic Agents; Hormones; Humans; Neoplasms; Peptides; Receptors, Cell Surface; arginylglycylaspartic acid; cytotoxic factor; hormone receptor; hormone receptor blocking agent; immune checkpoint inhibitor; nanoparticle; peptide; protein tyrosine kinase; small molecule transport agent; tumor homing peptide; unclassified drug; antineoplastic agent; cell surface receptor; hormone; peptide; adoptive immunotherapy; binding affinity; cancer therapy; chimeric antigen receptor immunotherapy; cytotoxic T lymphocyte; drug delivery system; drug penetration; exosome; human; internalization (cell); ligand binding; malignant neoplasm; nonhuman; peptide receptor radionuclide therapy; predictive value; protein function; protein protein interaction; Review; chemistry; metabolism; neoplasm | English | 2023 | 2023-06 | 10.1038/s12276-023-01016-x | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Review | Targeting glutamine metabolism as a therapeutic strategy for cancer | Proliferating cancer cells rely largely on glutamine for survival and proliferation. Glutamine serves as a carbon source for the synthesis of lipids and metabolites via the TCA cycle, as well as a source of nitrogen for amino acid and nucleotide synthesis. To date, many studies have explored the role of glutamine metabolism in cancer, thereby providing a scientific rationale for targeting glutamine metabolism for cancer treatment. In this review, we summarize the mechanism(s) involved at each step of glutamine metabolism, from glutamine transporters to redox homeostasis, and highlight areas that can be exploited for clinical cancer treatment. Furthermore, we discuss the mechanisms underlying cancer cell resistance to agents that target glutamine metabolism, as well as strategies for overcoming these mechanisms. Finally, we discuss the effects of glutamine blockade on the tumor microenvironment and explore strategies to maximize the utility of glutamine blockers as a cancer treatment. Cancer: Targeting glutamine metabolism as potential treatment Further insights into metabolic reprogramming by cancer cells are needed to determine if targeting glutamine metabolism could be a useful therapeutic approach. Cancer cells rely on the amino acid glutamine for growth and proliferation. Glutamine is a key nitrogen source and enables the cells to synthesize critical molecules including lipids and metabolites. Blocking glutamine metabolism may be useful in treating cancers, but care must be taken due to glutamine's multiple roles. Keun-Gyu Park and Yeon-Kyung Choi at Kyungpook National University in Daegu, South Korea, and co-workers reviewed current knowledge of the steps involved in glutamine metabolism to identify opportunities for intervention. Cancers can evade glutamine metabolism inhibition by manipulating the tumor microenvironment and finding alternative ways to source nutrients. Drug trials have targeted aspects of glutamine metabolism with mixed success, inhibition of glutamine transporters showing promise. | Jin, Jonghwa; Byun, Jun-Kyu; Choi, Yeon-Kyung; Park, Keun-Gyu | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Pharmaceut Sci Res Inst, Coll Pharm, BK21 FOUR Community Based Intelligent Novel Drug, Daegu 41566, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Chilgok Hosp, Sch Med, Dept Internal Med, Daegu 41404, South Korea | 57223246243; 57190427423; 35335932600; 57202558343 | ykchoi@knu.ac.kr;kpark@knu.ac.kr; | EXPERIMENTAL AND MOLECULAR MEDICINE | EXP MOL MED | 1226-3613 | 2092-6413 | 55 | 4 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL | 2023 | 9.5 | 6.6 | 14.9 | 2025-06-25 | 242 | 249 | AMINO-ACID TRANSPORTER; COLORECTAL-CANCER; TUMOR-GROWTH; CELL-GROWTH; EXPRESSION; DEPRIVATION; ACTIVATION; ADAPTATION; PATHWAY; GLUTATHIONE | Amino Acids; Citric Acid Cycle; Glutamine; Humans; Neoplasms; Oxidation-Reduction; Tumor Microenvironment; alanine aminotransferase; amino acid transporter; asparaginase; aspartate aminotransferase; atezolizumab; cabozantinib; cyclic GMP; everolimus; gemcitabine; glucose transporter 4; glutamate cysteine ligase; glutamic acid; glutamine; glutathione; glutathione synthase; interleukin 10; interleukin 12; interleukin 2; kynurenine; mammalian target of rapamycin; Myc protein; nivolumab; palbociclib; phosphoinositide dependent protein kinase 1; programmed death 1 ligand 1; protein p53; proteome; reactive oxygen metabolite; salazosulfapyridine; tyrosine; amino acid; glutamine; antineoplastic activity; apoptosis; bladder cancer; breast cancer; cancer cell; cancer chemotherapy; cancer growth; cancer immunotherapy; carbon source; carcinogenesis; CD8+ T lymphocyte; cell cycle arrest; cell viability; colorectal cancer; diffuse large B cell lymphoma; DNA methylation; endometrium cancer; endoplasmic reticulum stress; glioblastoma; glioma; glucose transport; glutamine metabolism; glycolysis; glycosylation; head and neck squamous cell carcinoma; human; human cell; hypoxia; immunosuppressive treatment; insulin resistance; lipid metabolism; lung metastasis; malignant neoplasm; melanoma; metabolomics; mouse; mRNA expression level; natural killer cell; necroptosis; nonhuman; nuclear reprogramming; nucleotide metabolism; osteosarcoma; oxidation reduction reaction; oxidative phosphorylation; oxidative stress; pancreas cancer; pentose phosphate cycle; prostate cancer; protein synthesis; proteomics; regulatory T lymphocyte; Review; signal transduction; stomach cancer; T cell lymphoma; Th1 cell; Th17 cell; triple negative breast cancer; tumor associated leukocyte; tumor growth; tumor immunity; tumor microenvironment; unfolded protein response; upregulation; uterine cervix cancer; citric acid cycle; metabolism; neoplasm | English | 2023 | 2023-04 | 10.1038/s12276-023-00971-9 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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