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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Hydroxamic Acid as a Potent Metal-Binding Group for Inhibiting Tyrosinase | Tyrosinase, a metalloenzyme containing a dicopper cofactor, plays a central role in synthesizing melanin from tyrosine. Many studies have aimed to identify small-molecule inhibitors of tyrosinase for pharmaceutical, cosmetic, and agricultural purposes. In this study, we report that hydroxamic acid is a potent metal-binding group for interacting with dicopper atoms, thereby inhibiting tyrosinase. Hydroxamate-containing molecules, including anticancer drugs targeting histone deacetylase, vorinostat and panobinostat, significantly inhibited mushroom tyrosinase, with inhibitory constants in the submicromolar range. Of the tested molecules, benzohydroxamic acid was the most potent. Its inhibitory constant of 7 nM indicates that benzohydroxamic acid is one of the most potent tyrosinase inhibitors. Results from differential scanning fluorimetry revealed that direct binding mediates inhibition. The enzyme kinetics were studied to assess the inhibitory mechanism of the hydroxamate-containing molecules. Experiments with B16F10 cell lysates confirmed that the new inhibitors are inhibitory against mammalian tyrosinase. Docking simulation data revealed intermolecular contacts between hydroxamate-containing molecules and tyrosinase. | Choi, Joonhyeok; Neupane, Trilok; Baral, Rishiram; Jee, Jun-Goo | Kyungpook Natl Univ, Pharmaceut Sci Res Inst, Coll Pharm, 80 Daehak Ro, Daegu 41566, South Korea | BARAL, RISHIRAM/CAH-2116-2022 | 56849594100; 57376280100; 57428055000; 7004327823 | crowz124@naver.com;ozitrilok99@gmail.com;rishirambaral1996@gmail.com;jjee@knu.ac.kr; | ANTIOXIDANTS | ANTIOXIDANTS-BASEL | 2076-3921 | 11 | 2 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY | 2022 | 7 | 8.8 | 0.77 | 2025-06-25 | 7 | 8 | cheminformatics; docking simulation; histone deacetylase; hydroxamic acid; tyrosinase | ACCURATE DOCKING; CATECHOL OXIDASE; AGENTS; METALLOPROTEINS; ANTIOXIDANT; PERSPECTIVE; DERIVATIVES; CHEMISTRY; MECHANISM; DISCOVERY | Cheminformatics; Docking simulation; Histone deacetylase; Hydroxamic acid; Tyrosinase | English | 2022 | 2022-02 | 10.3390/antiox11020280 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Inhibition of NADPH Oxidases Prevents the Development of Osteoarthritis | Increased oxidative stress in osteoarthritis (OA) cartilage mediates catabolic signal transduction leading to extracellular matrix degradation and chondrocyte apoptosis. This study aimed to explore the contribution of NADPH oxidase (NOX), a major source of cellular reactive oxygen species (ROS), to the catabolic process of chondrocytes and to OA. The inhibition of NOX isoforms with a pan-NOX inhibitor, APX-115, significantly decreased IL-1 beta-induced ROS production in primary chondrocytes and, most potently, suppressed the expression of oxidative stress marker genes and catabolic proteases compared with the inhibition of other ROS sources. Catabolic stimuli by IL-1 beta treatment and in post-traumatic OA conditions upregulated the expression of NOX2 and NOX4 in chondrocytes. In the post-traumatic OA model, the pharmacologic inhibition of NOX protected mice against OA by modulating the oxidative stress and the expression of MMP-13 and Adamts5 in chondrocytes. Mechanistically, NOX inhibition suppresses Rac1, p38, and JNK MAPK signaling consistently and restores oxidative phosphorylation in IL-1 beta-treated chondrocytes. In conclusion, NOX inhibition prevented the development of OA by attenuating the catabolic signaling and restoring the mitochondrial metabolism and can thus be a promising class of drug for OA. | Han, Jin; Park, Donghwi; Park, Ji Young; Han, Seungwoo | Kyungpook Natl Univ, Res Inst Aging & Metab, Lab Arthrit & Cartilage Biol, Daegu 41404, South Korea; Ulsan Univ, Sch Med, Dept Rehabil Med, Ulsan 44033, South Korea; Kyungpook Natl Univ Hosp, Sch Med, Dept Pathol, 807 Hoguk Ro, Daegu 41404, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Div Rheumatol, 807 Hoguk Ro, Daegu 41404, South Korea | ; Han, Seungwoo/R-5326-2019 | 57218360938; 56606561400; 57210160197; 55246807000 | jyparkmd@knu.ac.kr;kiefedr@knu.ac.kr; | ANTIOXIDANTS | ANTIOXIDANTS-BASEL | 2076-3921 | 11 | 12 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY | 2022 | 7 | 8.8 | 1.81 | 2025-06-25 | 19 | 19 | osteoarthritis; NADPH oxidase; oxidative stress; reactive oxygen species; chondrocyte | NOX4; MICE | chondrocyte; NADPH oxidase; osteoarthritis; oxidative stress; reactive oxygen species | English | 2022 | 2022-12 | 10.3390/antiox11122346 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Interfacial effects in an inorganic/organic composite based on Bi2Te3 inducing decoupled transport properties and enhanced thermoelectric performance | An inorganic/organic composite is suggested for low-temperature thermoelectric applications. An abundant and inexpensive conducting polymer, poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS), is introduced into n-type Bi2Te3, thus affording a bulk-phase composite, in which an interfacial energy barrier may occur at the component interfaces. These interfaces interfere with charge carrier transport, and thus the composite exhibits somewhat higher electrical resistivity than pristine Bi2Te3. However, the interfacial energy barrier can cause an energy filtering effect; thus, the composite exhibits a higher Seebeck coefficient than the pristine Bi2Te3. This Seebeck coefficient improvement is high enough to compensate for the resistivity increase, and thus the composite affords a significantly higher power factor than Bi2Te3. The composite exhibits lower lattice and carrier thermal conductivities than Bi2Te3, because the composite includes the interfaces possibly causing vigorous phonon scattering, and it exhibits relatively low carrier mobility. The composite is observed to show much lower total thermal conductivity than Bi2Te3. Consequently, the electrical and thermal properties are decoupled in the composite, resulting in remarkably enhanced thermoelectric performance (ZT(max) similar to 1.19@132 degrees C; ZT(ave) similar to 1.14@50-150 degrees C), which is approximately double that of Bi2Te3. Not only are the ZT values predominant among those of n-type Bi2Te3 analogues but they are also as competent as those of n-type Bi2Te3-based ternary substances. The composite is expected to be an excellent counterpart of p-type Bi2Te3, and thus it should be highly applicable to promising low-temperature thermoelectric operations, such as sustainable energy harvesting devices and systems. | Kim, Cham; Cho, Jaehun; Kim, Taewook; Lopez, David Humberto | Daegu Gyeongbuk Inst Sci & Technol DGIST, 333 Techno Jungang Daero, Daegu 42988, South Korea; Kyungpook Natl Univ, Dept Energy Chem Engn, Sangju 37224, South Korea; Univ Arizona, Dept Chem & Environm Engn, 1133 E James E Rogers Way, Tucson, AZ 85721 USA | Cho, Jaehun/P-6452-2019; Kim, Taewook/GSD-3143-2022 | 20433694400; 55474139500; 57030752600; 57132101100 | charming0207@dgist.ac.kr; | JOURNAL OF MATERIALS CHEMISTRY A | J MATER CHEM A | 2050-7488 | 2050-7496 | 10 | 26 | SCIE | CHEMISTRY, PHYSICAL;ENERGY & FUELS;MATERIALS SCIENCE, MULTIDISCIPLINARY | 2022 | 11.9 | 8.8 | 0.83 | 2025-06-25 | 14 | 15 | BISMUTH TELLURIDE NANOPARTICLES; CONDUCTIVITY; FIGURE; POLY(3,4-ETHYLENEDIOXYTHIOPHENE); NANOCOMPOSITES; MORPHOLOGY; EFFICIENCY; ELECTRODE; LATTICE; MERIT | Bismuth compounds; Carrier mobility; Conducting polymers; Energy barriers; Interfacial energy; Seebeck coefficient; Tellurium compounds; Temperature; Bulk phase; Ethylenedioxythiophenes; Inorganic/organic composites; Interfacial effects; Interfacial energy barrier; Lows-temperatures; Phase composites; Poly(styrene sulfonate); Thermoelectric application; Thermoelectric performance; Energy harvesting | English | 2022 | 2022-07-05 | 10.1039/d2ta02334b | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Lemon Balm and Corn Silk Mixture Alleviates Metabolic Disorders Caused by a High-Fat Diet | We recently reported that varying combination ratios of lemon balm (Melissa officinalis L.) and corn silk extracts (Stigma of Zea mays L. fruit) could reduce the obesity caused by a high-fat diet (HFD). The present study investigated the dose-dependent effect of a 1:1 (w:w) mixture of lemon balm and corn silk extracts (M-LB/CS) on HFD-mediated metabolic disorders and compared the effect with metformin. Oral administration of 50-200 mg/kg of M-LB/CS for 84 days significantly inhibited HFD-induced body weight gain, adipocyte hypertrophy, and lipogenic gene induction without affecting food consumption in mice. Biochemical analyses showed that M-LB/CS blocked abnormal lipid accumulation in the blood by escalating fecal lipid excretion. In addition, M-LB/CS prevented HFD-mediated pancreatic atrophy, decreased the number of insulin- and glucagon-immunoreactive cells, and inhibited increases in glycated hemoglobin, glucose, and insulin. Moreover, M-LB/CS also reduced hepatic injury, lipid accumulation, gluconeogenesis, and lipid peroxidation in parallel with the induction of AMP-activated protein kinase and antioxidant enzymes. Furthermore, M-LB/CS protected the kidney by inhibiting tubular vacuolation and reducing serum creatinine and blood urea nitrogen levels. The prophylactic effect of 100 mg/kg M-LB/CS-administration was comparable to that of metformin. Therefore, M-LB/CS may be an alternative option for managing obesity and its related metabolic disorders. | Cho, Il-Je; Shin, Joung-Hoon; Choi, Beom-Rak; Park, Hye-Rim; Park, Jeong-Eun; Hong, Seong-Hwa; Kwon, Young-Sam; Oh, Won-Seok; Ku, Sae-Kwang | Daegu Haany Univ, Coll Korean Med, Dept Preparatory Korean Med, Gyongsan 38610, South Korea; Kyungpook Natl Univ, Coll Vet Med, Dept Vet Surg, Daegu 41566, South Korea; Nutracore Co Ltd, Gwanggyo SK Viewlake A-3206,Beobjo Ro 25, Suwon 16514, South Korea; Kyungpook Natl Univ, Coll Vet Med, Dept Vet Internal Med, Daegu 41566, South Korea | 36241202500; 57563158100; 56595969400; 56595786600; 57374589500; 57375011800; 7403459426; 35208796100; 7006331005 | skek023@gmail.com;newyorkah@knu.ac.kr;brchoi@nutracore.co.kr;hrpark@nutracore.co.kr;jpark@nutracore.co.kr;shhong@nutracore.co.kr;kwon@knu.ac.kr;owsvcs@hanmail.net;gucci200@dhu.ac.kr; | ANTIOXIDANTS | ANTIOXIDANTS-BASEL | 2076-3921 | 11 | 4 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY | 2022 | 7 | 8.8 | 0.38 | 2025-06-25 | 4 | 4 | corn silk (stigma of Zea mays L. fruit); high-fat diet (HFD); lemon balm (Melissa officinalis L.); 1:1 (w:w) mixture of lemon balm and corn silk extracts (M-LB/CS); metabolic disorders | ACTIVATED PROTEIN-KINASE; MELISSA-OFFICINALIS L.; INSULIN-RESISTANCE; LIPID-ACCUMULATION; OXIDATIVE STRESS; ROSMARINIC ACID; INDUCED HEPG2; PPAR-GAMMA; AMPK; OBESITY | 1:1 (w:w) mixture of lemon balm and corn silk extracts (M-LB/CS); corn silk (stigma of Zea mays L. fruit); high-fat diet (HFD); lemon balm (Melissa officinalis L.); metabolic disorders | English | 2022 | 2022-04 | 10.3390/antiox11040730 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Li-ion conductivity in Li2OHCl1-xBrx solid electrolytes: grains, grain boundaries and interfaces | In this study, we conduct a comprehensive investigation of the effect of grain, grain boundary and interfacial resistance on the total Li-ion conductivity in Li2OHCl1-xBrx antiperovskite solid electrolytes. We highlight how the thermal expansion coefficient can serve as an indicator for the presence of structural defects, which are difficult to probe directly with X-ray techniques, and their effect on bulk Li-ion conduction. The detrimental effect of grain boundaries on ionic conductivity is investigated by atomistic calculations and validated experimentally by electrochemical impedance spectroscopy on pellets with controlled grain size. The effect of composition on interfacial resistance is probed by electrochemical impedance spectroscopy and X-ray photoelectron spectroscopy. These insights provide design principles to improve Li-ion conductivity in lithium hydroxide halide antiperovskites. | Lee, Hyeon Jeong; Darminto, Brigita; Narayanan, Sudarshan; Diaz-Lopez, Maria; Xiao, Albert W.; Chart, Yvonne; Lee, Ji Hoon; Dawson, James A.; Pasta, Mauro | Univ Oxford, Dept Mat, Parks Rd, Oxford OX1 3PH, England; Diamond Light Source Ltd, Diamond House,Harwell Sci & Innovat Campus, Didcot OX11 0DE, Oxon, England; Kyungpook Natl Univ, Sch Mat Sci & Engn, 80 Daehak Ro, Daegu 41566, South Korea; Newcastle Univ, Chem Sch Nat & Environm Sci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England; Newcastle Univ, Ctr Energy, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England | ; Dawson, James/GZH-1195-2022; Pasta, Mauro/B-8164-2012; Xiao, Albert/HZJ-7193-2023; Diaz-Lopez, Maria/AAA-8161-2022; Lee, Ji Hoon/T-4913-2017; Lee, Ji/AAU-7285-2021 | 56711412600; 57485708300; 57224316999; 57201295659; 57208546154; 57209210397; 55689885200; 36902807300; 24503276200 | mauro.pasta@materials.ox.ac.uk; | JOURNAL OF MATERIALS CHEMISTRY A | J MATER CHEM A | 2050-7488 | 2050-7496 | 10 | 21 | SCIE | CHEMISTRY, PHYSICAL;ENERGY & FUELS;MATERIALS SCIENCE, MULTIDISCIPLINARY | 2022 | 11.9 | 8.8 | 2.08 | 2025-06-25 | 37 | 38 | LITHIUM-ION; TRANSPORT MECHANISM; THERMAL-EXPANSION; STATE; STABILITY | Electrochemical impedance spectroscopy; Grain boundaries; Ions; Solid electrolytes; Thermal expansion; X ray photoelectron spectroscopy; Antiperovskite; Electrochemical-impedance spectroscopies; Grain boundary resistance; Grain interface; Grain-grain boundaries; Interfacial resistances; Li ion conductivities; Structural defect; Thermal expansion coefficients; X-ray techniques; Lithium compounds | English | 2022 | 2022-05-31 | 10.1039/d2ta01462a | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Luteolin Synergistically Enhances Antitumor Activity of Oxaliplatin in Colorectal Carcinoma via AMPK Inhibition | Luteolin is a naturally-occurring polyphenolic compound that is known to have antioxidative and antitumor activities in vitro. This study aimed to examine the in vivo anticancer efficacy of luteolin in conjunction with oxaliplatin treatment using a colorectal carcinoma xenograft mouse model. HCT116 human colorectal carcinoma cells were subcutaneously implanted into BALB/c nude mice, followed by the intraperitoneal administration of luteolin at a dose of 50 mg/kg body weight (BW)/day with or without oxaliplatin at a dose of 10 mg/kg BW/day three times per week for a total of 3 weeks. The combined luteolin and oxaliplatin treatment resulted in the synergistic suppression of the growth of HCT116 xenograft tumors when compared to treatment with luteolin or oxaliplatin alone. In addition, the combined treatment significantly increased the expression of cleaved PARP and p53 in the xenograft tumors compared with the vehicle control, but only marginally affected the level of heme oxygenase-1 (HO-1). These results indicated that luteolin treatment retarded oxaliplatin-induced tumor growth by facilitating apoptotic cell death and inhibiting HO-1-mediated cytoprotection. Therefore, these findings suggest the synergistic potential of dietary luteolin in conjunction with conventional chemotherapy for the treatment of colorectal cancer. | Jang, Chan Ho; Moon, Nayoung; Lee, Jinkyung; Kwon, Min Jeong; Oh, Jisun; Kim, Jong-Sang | Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Daegu Gyeongbuk Med Innovat Fdn, New Drug Dev Ctr, Daegu 41061, South Korea | 24477187500; 57208479293; 57546632200; 57547402100; 56311554100; 37106950100 | cksghwkd7@gmail.com;moonna1008@naver.com;wlsrud9526@naver.com;rnjsalswjd1005@naver.com;joh@kmedihub.re.kr;vision@knu.ac.kr; | ANTIOXIDANTS | ANTIOXIDANTS-BASEL | 2076-3921 | 11 | 4 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY | 2022 | 7 | 8.8 | 2.66 | 2025-06-25 | 28 | 28 | luteolin; oxaliplatin; colorectal cancer; xenograft tumor; AMPK inhibition | HEME OXYGENASE-1; CANCER CHEMOPREVENTION; SIGNALING PATHWAY; GENE-EXPRESSION; COLON-CANCER; NRF2; ACTIVATION; INDUCTION; PREVENTION; CELLS | AMPK inhibition; Colorectal cancer; Luteolin; Oxaliplatin; Xenograft tumor | English | 2022 | 2022-04 | 10.3390/antiox11040626 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Metabolic Basis and Clinical Evidence for Skin Lightening Effects of Thiol Compounds | Melanin pigment is a major factor in determining the color of the skin, and its abnormal increase or decrease can cause serious pigmentation disorders. The melanin pigment of the skin is divided into light pheomelanin and dark eumelanin, and a big difference between them is whether they contain sulfur. Melanin synthesis starts from a common reaction in which tyrosine or dihydroxyphenylalanine (DOPA) is oxidized by tyrosinase (TYR) to produce dopaquinone (DQ). DQ is spontaneously converted to leukodopachrome and then oxidized to dopachrome, which enters the eumelanin synthesis pathway. When DQ reacts with cysteine, cysteinyl dopa is generated, which is oxidized to cysteinyl DQ and enters the pheomelanin synthesis pathway. Therefore, thiol compounds can influence the relative synthesis of eumelanin and pheomelanin. In addition, thiol compounds can inhibit enzymatic activity by binding to copper ions at the active site of TYR, and act as an antioxidant scavenging reactive oxygen species and free radicals or as a modulator of redox balance, thereby inhibiting overall melanin synthesis. This review will cover the metabolic aspects of thiol compounds, the role of thiol compounds in melanin synthesis, comparison of the antimelanogenic effects of various thiol compounds, and clinical trials on the skin lightening efficacy of thiol compounds. We hope that this review will help identify the advantages and disadvantages of various thiol compounds as modulators of skin pigmentation and contribute to the development of safer and more effective strategies for the treatment of pigmentation disorders. | Boo, Yong Chool | Kyungpook Natl Univ, Sch Med, Dept Mol Med, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, BK21 Plus KNU Biomed Convergence Program, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, 680 Gukchaebosang Ro, Daegu 41944, South Korea | 6602899130 | ycboo@knu.ac.kr; | ANTIOXIDANTS | ANTIOXIDANTS-BASEL | 2076-3921 | 11 | 3 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY | 2022 | 7 | 8.8 | 0.63 | 2025-06-25 | 17 | 15 | melanin synthesis; eumelanin; pheomelanin; thiol compound; sulfhydryl compound; skin pigmentation; pigmentary disorder | SIGNALING PATHWAYS; HUMAN TYROSINASE; DOUBLE-BLIND; MAMMALIAN MELANOGENESIS; GLUTATHIONE-REDUCTASE; CULTURED MELANOCYTES; MELANIN PIGMENTATION; S-ADENOSYLMETHIONINE; SERUM HOMOCYSTEINE; EPIDERMAL MELASMA | Eumelanin; Melanin synthesis; Pheomelanin; Pigmentary disorder; Skin pigmentation; Sulfhydryl compound; Thiol compound | English | 2022 | 2022-03 | 10.3390/antiox11030503 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Metabolite Profiling of Microwave-Assisted Sargassum fusiforme Extracts with Improved Antioxidant Activity Using Hybrid Response Surface Methodology and Artificial Neural Networking-Genetic Algorithm | Sargassum fusiforme (SF) is a popular edible brown macroalga found in Korea, Japan, and China and is known for its health-promoting properties. In this study, we used two sophisticated models to obtain optimized conditions for high antioxidant activity and metabolite profiling using high-resolution mass spectrometry. A four-factor central composite design was used to optimize the microwave-assisted extraction and achieve the maximum antioxidant activities of DPPH (Y-1: 28.01 % inhibition), ABTS (Y-2: 36.07 % inhibition), TPC (Y-3: 43.65 mg GAE/g), and TFC (Y-4: 17.67 mg CAE/g), which were achieved under the optimized extraction conditions of X-1: 47.67 %, X-2: 2.96 min, X-3: 139.54 degrees C, and X-4: 600.00 W. Moreover, over 79 secondary metabolites were tentatively identified, of which 12 compounds were reported for the first time in SF, including five phenolic (isopropyl 3-(3,4-dihydroxyphenyl)-2-hydroxypropanoate, 3,4-dihydroxyphenylglycol, scopoletin, caffeic acid 4-sulfate, and cinnamoyl glucose), two flavonoids (4',7-dihydroxyisoflavone and naringenin), three phlorotannins (diphlorethohydroxycarmalol, dibenzodioxin-1,3,6,8-tetraol, and fucophlorethol), and two other compounds (dihydroxyphenylalanine and 5-hydroxybenzofuran-2(3H)-one) being identified for the first time in optimized SF extract. These compounds may also be involved in improving the antioxidant potential of the extract. Therefore, optimized models can provide better estimates and predictive capabilities that would assist in finding new bioactive compounds with improved biological activities that can be further applied at a commercial level. | Javed, Ahsan; Naznin, Marufa; Alam, Md. Badrul; Fanar, Alshammari; Song, Bo-Rim; Kim, Sunghwan; Lee, Sang-Han | Kyungpook Natl Univ, Grad Sch, Dept Food Sci & Biotechnol, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Kyungpook Natl Univ, Food & Bioind Res Inst, Inner Beauty Antiaging Ctr, Daegu 41566, South Korea; Kyungpook Natl Univ, Mass Spect Converging Res Ctr, Green Nano Mat Res Ctr, Daegu 41566, South Korea | Alam, Md Badrul/AFL-7668-2022; Lee, Seung Eun/ABG-1607-2021; ALAM, MD BADRUL/AFL-7668-2022; Javed, Ahsan/ABK-2648-2022; Kim, Sunghwan/HKN-9812-2023 | 57204433098; 57195955389; 56706777100; 57218551129; 57223138662; 57203772967; 57221453703 | sunghwank@knu.ac.kr;sang@knu.ac.kr; | ANTIOXIDANTS | ANTIOXIDANTS-BASEL | 2076-3921 | 11 | 11 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY | 2022 | 7 | 8.8 | 1.24 | 2025-06-25 | 11 | 13 | Sargassum fusiforme; microwave-assisted extraction; secondary metabolites; antioxidant activity | POLYPHENOLIC COMPOUNDS; OPTIMIZATION; EXPRESSION; FUCOIDAN; SEAWEEDS; MODEL; RSM | antioxidant activity; microwave-assisted extraction; Sargassum fusiforme; secondary metabolites | English | 2022 | 2022-11 | 10.3390/antiox11112246 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Nanostructural Engineering of Electrospun Poly(vinyl alcohol)/Carbon Nanotube Mats into Dense Films for Alcohol Dehydration | Pervaporation is a green process that consumes low energy and does not require solvents for separation. In this work, interfacial engineering of poly(vinyl alcohol) (PVA)/carbon nanotube (CNT) electrospun fibers was attempted to fabricate dense membranes for pervaporation. Ethanol and water were used as nonsolvent and solvent, respectively, to alter the nanoscopic configuration of the fibers through interfacial solvent interactions. PVA and PVA/CNT mats with micron-sized pores (>100 mu m) were prepared by optimizing electrospinning conditions. The mats were compacted via immersion in ethanol. They exhibited asymmetric close-packed top and bottom layers and porous intermediate layers. Further consolidation was achieved using water to fuse the fibers. The mats with more than 1.5 wt % CNT loading were stable against water owing to the cross-linking between CNTs and PVA. Because of the uniform dispersion of CNTs into the PVA matrix, the PVA/CNT dense films exhibited higher water/ethanol selectivity and water flux than those exhibited by similar films prepared by solution-casting. Thus, simple interfacial engineering of electrospun mats presented in this work successfully generates high-performance PVA/CNT membranes. A high alcohol dehydration performance and time-efficient membrane fabrication are achieved. | Kang, Su Kyung; Hwang, Kyujin; Park, Ju Won; Ha Kim, Min; Lee, Pyung Soo; Jeong, Soo-Hwan | Chung Ang Univ, Dept Chem Engn & Mat Sci, Seoul 06974, South Korea; Kyungpook Natl Univ, Dept Chem Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Hydrogen & Renewable Energy, Daegu 41566, South Korea; Chung Ang Univ, Dept Intelligent Energy & Ind, Seoul 06974, South Korea | ; Park, Ju Won/LBN-1834-2024; , SooHwanJeong/JOJ-6732-2023 | 57221945961; 57918162300; 57223123285; 57918560900; 55474663100; 7402425359 | leeps@cau.ac.kr;shjeong@knu.ac.kr; | ACS SUSTAINABLE CHEMISTRY & ENGINEERING | ACS SUSTAIN CHEM ENG | 2168-0485 | 10 | 40 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;ENGINEERING, CHEMICAL;GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY | 2022 | 8.4 | 8.8 | 0.41 | 2025-06-25 | 7 | 7 | electrospinning; poly(vinyl alcohol) (PVA); carbon nanotube (CNT); surface functionalization; interfacial engineering; alcohol dehydration; PVA composite membrane; electrospun PVA membrane | COMPOSITE MEMBRANES; MECHANICAL-PROPERTIES; CARBON NANOTUBES; PERVAPORATION; PERFORMANCE; WATER; FABRICATION; CARRIERS | alcohol dehydration; carbon nanotube (CNT); electrospinning; electrospun PVA membrane; interfacial engineering; poly(vinyl alcohol) (PVA); PVA composite membrane; surface functionalization | Composite membranes; Dehydration; Electrospinning; Ethanol; Evaporation; Film preparation; Nanocomposite films; Organic solvents; Pervaporation; Polyvinyl alcohols; Alcohol dehydration; Carbon nanotube; Electrospun PVA membrane; Electrospuns; Interfacial engineering; Poly (vinyl alcohol) (PVA); Poly(vinyl alcohol) (PVA); PVA composite membrane; PVA membrane; Surface Functionalization; Carbon nanotubes | English | 2022 | 2022-09-29 | 10.1021/acssuschemeng.2c03574 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | NRF2 Activation in Autophagy Defects Suppresses a Pharmacological Transactivation of the Nuclear Receptor FXR | NF-E2-related factor 2 (NRF2), an antioxidant transcription factor, is activated in autophagy-deficient mice due to the accumulations of p62/SQSTM1 and its subsequent interaction with Kelch-like-ECH-associated protein 1 (KEAP1), an adaptor component for Cullin3-based E3 ubiquitin ligase complex. Farnesoid x receptor (FXR/NR1H4) is a ligand-dependent transcription factor that belongs to the nuclear receptor superfamily. FXR plays an essential role in bile acid synthesis and enterohepatic circulation, affecting glucose and lipid metabolism. Obeticholic acid as a potent FXR agonist has been approved to treat primary biliary cholangitis and clinical trials for its use in the treatment of other liver diseases are underway. Here we show that NRF2 activation in autophagy defects impedes a transactivation of FXR. Liver-specific Atg7 knockout mice or a treatment of autophagy inhibitor showed decreased inductions of FXR target genes upon its synthetic agonists. Moreover, enforced NRF2 activations with small molecules potently decreased the pharmacological activation of FXR in cultured cells. Finally, we demonstrate that NRF2 activation by the treatment with the food antioxidant butylated hydroxyanisole is necessary and sufficient to inhibit the pharmacological activation of FXR in vivo. These results reveal a novel function of the basal autophagy-NRF2 axis for the regulation of FXR transactivation, and shed light on a potential therapeutic strategy in metabolic disease. | Kim, Eun Young; Lee, Jae Man | Kyungpook Natl Univ, Sch Med, Cell & Matrix Res Inst, Dept Biochem & Cell Biol, Daegu 41944, South Korea; Kyungpook Natl Univ, Grad Sch, Dept Biomed Sci, BK21 FOUR KNU Biomed Convergence Program, Daegu 41944, South Korea | Lee, Jae/KFF-5361-2024; Kim, YoungHwan/B-2395-2013 | 57194632567; 47461355200 | key11@knu.ac.kr;jaemanlee@knu.ac.kr; | ANTIOXIDANTS | ANTIOXIDANTS-BASEL | 2076-3921 | 11 | 2 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY | 2022 | 7 | 8.8 | 0.1 | 2025-06-25 | 4 | 2 | autophagy; nrf2; keap1; nuclear receptor; FXR; transactivation; ligand | TRANSCRIPTION FACTOR NRF2; FARNESOID-X-RECEPTOR; BILE-ACID; INDUCIBLE EXPRESSION; KEAP1-NRF2 SYSTEM; OXIDATIVE STRESS; MAF; DETOXIFICATION; IDENTIFICATION; METABOLISM | Autophagy; FXR; Keap1; Ligand; Nrf2; Nuclear receptor; Transactivation | English | 2022 | 2022-02 | 10.3390/antiox11020370 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Over-Expression of Dehydroascorbate Reductase Improves Salt Tolerance, Environmental Adaptability and Productivity in Oryza sativa | Abiotic stress induces reactive oxygen species (ROS) generation in plants, and high ROS levels can cause partial or severe oxidative damage to cellular components that regulate the redox status. Here, we developed salt-tolerant transgenic rice plants that overexpressed the dehydroascorbate reductase gene (OsDHAR1) under the control of a stress-inducible sweet potato promoter (SWPA2). OsDHAR1-expressing transgenic plants exhibited improved environmental adaptability compared to wild-type plants, owing to enhanced ascorbate levels, redox homeostasis, photosynthetic ability, and membrane stability through cross-activation of ascorbate-glutathione cycle enzymes under paddy-field conditions, which enhanced various agronomic traits, including root development, panicle number, spikelet number per panicle, and total grain yield. dhar2-knockdown plants were susceptible to salt stress, and owing to poor seed maturation, exhibited reduced biomass (root growth) and grain yield under paddy field conditions. Microarray revealed that transgenic plants highly expressed genes associated with cell growth, plant growth, leaf senescence, root development, ROS and heavy metal detoxification systems, lipid metabolism, isoflavone and ascorbate recycling, and photosynthesis. We identified the genetic source of functional genomics-based molecular breeding in crop plants and provided new insights into the physiological processes underlying environmental adaptability, which will enable improvement of stress tolerance and crop species productivity in response to climate change. | Kim, Young-Saeng; Park, Seong-Im; Kim, Jin-Ju; Shin, Sun-Young; Kwak, Sang-Soo; Lee, Choon-Hwan; Park, Hyang-Mi; Kim, Yul-Ho; Kim, Il-Sup; Yoon, Ho-Sung | Kyungpook Natl Univ, Res Inst Ulleung Do & Dok Do, Daegu 41566, South Korea; Kyungpook Natl Univ, BK21 Plus KNU Creat BioResearch Grp, Sch Life Sci, Daegu 41566, South Korea; Kyungpook Natl Univ, Coll Nat Sci, Dept Biol, Daegu 41566, South Korea; Korea Res Inst Biosci & Biotechnol, Plant Syst Engn Res Ctr, Daejeon 34141, South Korea; Pusan Natl Univ, Dept Mol Biol, Busan 46241, South Korea; Rural Dev Adm, Natl Inst Crop Sci, Jeonju 54875, South Korea; Rural Dev Adm, Natl Inst Crop Sci, Highland Agr Res Inst, Pyeongchang 25342, South Korea; Kyungpook Natl Univ, Adv Bioresource Res Ctr, Daegu 41566, South Korea | Shin, Sun-Young/AAH-9914-2019 | 35798433500; 56310974600; 57203324864; 54943706600; 36837834400; 35233847200; 26425253900; 37084899500; 55477678200; 7402990205 | kyslhh1228@hanmail.net;sheep91528@naver.com;deenamon@naver.com;snowmooa@hanmail.net;sskwak@kribb.re.kr;chlee@pusan.ac.kr;parkhm2002@korea.kr;kimyuh77@korea.kr;92kis@hanmail.net;hsy@knu.ac.kr; | ANTIOXIDANTS | ANTIOXIDANTS-BASEL | 2076-3921 | 11 | 6 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY | 2022 | 7 | 8.8 | 1.81 | 2025-06-25 | 16 | 20 | ascorbate; ascorbate-glutathione system; dehydroascorbate reductase; reactive oxygen species; yield parameters | ASCORBATE-GLUTATHIONE CYCLE; MONODEHYDROASCORBATE REDUCTASE; STRESS-TOLERANCE; CONFERS TOLERANCE; MOLECULAR-CLONING; GRAIN-SIZE; RICE YIELD; CELL-CYCLE; GENE; PLANTS | ascorbate; ascorbate-glutathione system; dehydroascorbate reductase; reactive oxygen species; yield parameters | English | 2022 | 2022-06 | 10.3390/antiox11061077 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Peroxiredoxin 2 Ameliorates AβO-Mediated Autophagy by Inhibiting ROS via the ROS-NRF2-p62 Pathway in N2a-APP Swedish Cells | In Alzheimer's disease, reactive oxygen species (ROS) are generated by the deposition of amyloid-beta oligomers (A beta Os), which represent one of the important causes of neuronal cell death. Additionally, A beta Os are known to induce autophagy via ROS induction. Previous studies have shown that autophagy upregulation aggravates neuronal cell death. In this study, the effects of peroxiredoxin 2 (Prx2), a member of the peroxidase family of antioxidant enzymes, on regulating A beta O-mediated autophagy were investigated. Prx2 decreased A beta O-mediated oxidative stress and autophagy in N2a-APPswe cells. Further, we examined the relationship between the neuronal protective effect of Prx2 and a decrease in autophagy. Similar to the effects of N-acetyl cysteine, Prx2 decreased A beta O-induced ROS and inhibited p62 protein expression levels by downregulating the activation of NRF2 and its translocation to the nucleus. In addition, treatment with 3-methyladenine, an autophagy inhibitor, ameliorates neuronal cell death. Overall, these results demonstrate that the Prx2-induced decrease in autophagy was associated with the inhibition of ROS via the ROS-NRF2-p62 pathway in N2a-APPswe cells. Therefore, our results revealed that Prx2 is a potential therapeutic target in anti-Alzheimer therapy. | Jin, Wei; Kam, Min Kyoung; Lee, Sung Woo; Park, Young-Ho; Lee, Hong Jun; Lee, Dong-Seok | Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat BioRes Grp, Daegu 41566, South Korea; Kyungpook Natl Univ, Coll Nat Sci, Sch Life Sci & Biotechnol, Daegu 41566, South Korea; Korea Res Inst Biosci & Biotechnol KRIBB, Futurist Anim Resource & Res Ctr FARRC, Cheongju 28116, South Korea; Chungbuk Natl Univ, Coll Med & Med Res Inst, Cheongju 28644, South Korea; Res Inst eBiogen Inc, Seoul 04785, South Korea | lee, wj/JNR-4926-2023 | 57939719900; 57195564169; 57939888700; 56246852400; 35215736300; 57210068061 | lee1@knu.ac.kr; | ANTIOXIDANTS | ANTIOXIDANTS-BASEL | 2076-3921 | 11 | 10 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY | 2022 | 7 | 8.8 | 0.67 | 2025-06-25 | 7 | 7 | Alzheimer's disease; oxidative stress; autophagy; ROS-NRF2-p62 pathway; cell death; peroxiredoxin 2; N2a-APPswe cells | OXIDATIVE STRESS; NRF2; ACTIVATION; REGULATOR; DISEASE; TARGET; DEATH; PHASE; P62 | Alzheimer’s disease; autophagy; cell death; N2a-APPswe cells; oxidative stress; peroxiredoxin 2; ROS–NRF2–p62 pathway | English | 2022 | 2022-10 | 10.3390/antiox11101889 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Plant Response to Cold Stress: Cold Stress Changes Antioxidant Metabolism in Heading Type Kimchi Cabbage (Brassica rapa L. ssp. Pekinensis) | Cold stress is known as the important yield-limiting factor of heading type Kimchi cabbage (HtKc, Brassica rapa L. ssp. pekinensis), which is an economically important crop worldwide. However, the biochemical and molecular responses to cold stress in HtKc are largely unknown. In this study, we conducted transcriptome analyses on HtKc grown under normal versus cold conditions to investigate the molecular mechanism underlying HtKc responses to cold stress. A total of 2131 genes (936 up-regulated and 1195 down-regulated) were identified as differentially expressed genes and were significantly annotated in the category of "response to stimulus". In addition, cold stress caused the accumulation of polyphenolic compounds, including p-coumaric, ferulic, and sinapic acids, in HtKc by inducing the phenylpropanoid pathway. The results of the chemical-based antioxidant assay indicated that the cold-induced polyphenolic compounds improved the free-radical scavenging activity and antioxidant capacity, suggesting that the phenylpropanoid pathway induced by cold stress contributes to resistance to cold-induced reactive oxygen species in HtKc. Taken together, our results will serve as an important base to improve the cold tolerance in plants via enhancing the antioxidant machinery. | Eom, Seung Hee; Ahn, Min-A; Kim, Eunhui; Lee, Hee Ju; Lee, Jin Hyoung; Wi, Seung Hwan; Kim, Sung Kyeom; Lim, Heung Bin; Hyun, Tae Kyung | Chungbuk Natl Univ, Coll Agr Life & Environm Sci, Dept Ind Plant Sci & Technol, Cheongju 28644, South Korea; Natl Inst Hort & Herbal Sci, Vegetable Res Div, Wonju 55365, South Korea; Kyungpook Natl Univ, Coll Agr & Life Sci, Dept Hort Sci, Daegu 41566, South Korea | ; Kim, Sung Kyeom/AAD-9230-2019 | 55542463700; 57221597986; 57222360164; 59106640900; 48461594400; 58607882100; 50262290200; 7403095454; 35722113700 | eom0214@naver.com;koala0523@chungbuk.ac.kr;eh981102@gmail.com;perpetuaa@korea.kr;leejh0820@korea.kr;kgad@korea.kr;skkim76@knu.ac.kr;heungbin@chungbuk.ac.kr;taekyung7708@chungbuk.ac.kr; | ANTIOXIDANTS | ANTIOXIDANTS-BASEL | 2076-3921 | 11 | 4 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY | 2022 | 7 | 8.8 | 4.47 | 2025-06-25 | 47 | 47 | antioxidant; kimchi cabbage; cold stress; phenylpropanoid pathway | FREEZING TOLERANCE; ENZYMES; ACCLIMATION; EXPRESSION; GENE | antioxidant; cold stress; kimchi cabbage; phenylpropanoid pathway | English | 2022 | 2022-04 | 10.3390/antiox11040700 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Porous dendritic BiSn electrocatalysts for hydrogenation of 5-hydroxymethylfurfural | The electrocatalytic hydrogenation of 5-hydroxymethylfurfural (HMF) to 2,5-bis(hydroxymethyl)furan (BHMF) is an alternative to conventional heterogeneous catalysis with H-2 at high temperatures and pressures. Although Ag is the most representative electrocatalyst, it works only under limited conditions. This study synthesizes highly porous dendritic Bi, Sn, and BiSn electrocatalysts using an in situ generated hydrogen bubble template. Density functional theory computations on the adsorption energy and elementary hydrogenation reaction steps of HMF predict the superiority of Bi to Sn and the intermediate behavior of BiSn between Bi and Sn. The dendritic BiSn catalyst generates a current density of similar to 144 mA cm(-2) at a faradaic efficiency (FE) of similar to 100% for BHMF production at pH similar to 7 (corresponding to the BHMF production rate of similar to 2.7 mmol h(-1) cm(-2)) in prolonged electrolysis. Considering the material cost (<5% of Ag price) and quick synthesis (<40 s), dendritic BiSn should be a promising candidate for HMF hydrogenation. | Piao, Guangxia; Yoon, Sun Hee; Cha, Hyun Gil; Han, Dong Suk; Park, Hyunwoong | Kyungpook Natl Univ, Sch Energy Engn, Daegu 41556, South Korea; Texas A&M Univ Qatar, Petr Engn Program, Doha 23874, Qatar; Korea Res Inst Chem Technol, Ctr Biobased Chem, Ulsan 44429, South Korea; Qatar Univ, Ctr Adv Mat, Doha 2713, Qatar | Han, Dong Suk/Q-8641-2017; Park, Hyunwoong/A-1247-2012; Han, Dong SuK/AAX-9333-2021; Cha, Hyungil/ABG-4425-2020 | 57193277010; 55516458500; 15749867000; 36139213900; 7601565583 | dhan@qu.edu.qa;hwp@knu.ac.kr; | JOURNAL OF MATERIALS CHEMISTRY A | J MATER CHEM A | 2050-7488 | 2050-7496 | 10 | 45 | SCIE | CHEMISTRY, PHYSICAL;ENERGY & FUELS;MATERIALS SCIENCE, MULTIDISCIPLINARY | 2022 | 11.9 | 8.8 | 0.83 | 2025-06-25 | 13 | 15 | CATALYTIC CONVERSION; BIOMASS; REDUCTION; 2,5-BIS(HYDROXYMETHYL)FURAN; OXIDATION; EFFICIENT; WATER; CO2 | Catalysis; Density functional theory; Electrolysis; Hydrogenation; Reaction intermediates; Silver; 5 hydroxymethyl furfurals; Adsorption energies; Bis(hydroxymethyl); Condition; Dendritics; Density-functional-theory; Electrocatalytic hydrogenation; High temperature and pressure; Hydrogen bubble templates; Theory computation; Electrocatalysts | English | 2022 | 2022-11-22 | 10.1039/d2ta05969j | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Preventative Effects of Antioxidants against PM10 on Serum IgE Concentration, Mast Cell Counts, Inflammatory Cytokines, and Keratinocyte Differentiation Markers in DNCB-Induced Atopic Dermatitis Mouse Model | Particulate matter (PM) can cause oxidative stress, inflammation, and skin aging. We investigated the effects of antioxidants such as dieckol, punicalagin, epigallocatechin gallate (EGCG), resveratrol, and Siegesbeckiae Herba extract (SHE) against PM < 10 mu m (PM10) on serum IgE concentration, mast cell counts, inflammatory cytokines, and keratinocyte differentiation markers in a 2,4-Dinitrochlorobenzene (DNCB)-induced atopic dermatitis mouse model. Seven-week-old BALB/c mice were sensitized with 2% DNCB. Atopic dermatitis-like lesions were induced on the mice with 0.2% DNCB. Antioxidants and PM10 were applied to the mice for 4 weeks. PM10 increased the serum IgE concentration and spleen weight in mice, and all antioxidants downregulated these parameters. Histological examination showed an increase in epidermal thickness and mast cell counts in response to PM10, and all antioxidants showed a decrease. PM10 upregulates the expression of inflammatory cytokines, including interleukin (IL)-1 beta, IL-4, IL-6, IL-17 alpha, IL-25, IL-31 and thymic stromal lymphopoietin (TSLP) in mice, and all antioxidants inhibited the upregulation of inflammatory cytokines. ELISA showed the same results as real-time PCR. PM10 downregulates the expression of keratinocyte differentiation markers, including loricrin and filaggrin, in mouse keratinocytes and antioxidants prevented the downregulation of the keratinocyte differentiation markers. Conclusively, PM10 aggravated the DNCB-induced mouse model in serum IgE concentration, mast cell counts, inflammatory cytokine, and keratinocyte differentiation markers. In addition, antioxidants modulated changes in the DNCB-induced mouse model caused by PM10. | Kwack, Mi Hee; Bang, Jin Seon; Lee, Weon Ju | Kyungpook Natl Univ, Sch Med, Dept Immunol, BK21 FOUR KNU Convergence Educ Program Biomed Sci, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Dermatol, Daegu 41944, South Korea | 6507685557; 57781956500; 24474659000 | go3004@knu.ac.kr;jinsun9367@hanmail.net;weonju@knu.ac.kr; | ANTIOXIDANTS | ANTIOXIDANTS-BASEL | 2076-3921 | 11 | 7 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY | 2022 | 7 | 8.8 | 1.05 | 2025-06-25 | 12 | 11 | antioxidants; 2; 4-Dinitrochlorobenzene (DNCB)-induced atopic dermatitis mouse; particulate matter (PM)(10) | FINE PARTICULATE MATTER; EXPOSURE; SKIN; EXPRESSION; HEALTH; PM2.5 | 2,4-Dinitrochlorobenzene (DNCB)-induced atopic dermatitis mouse; antioxidants; particulate matter (PM)<sub>10</sub> | English | 2022 | 2022-07 | 10.3390/antiox11071334 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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