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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | Article | Antithrombotic regimen in emergent carotid stenting for acute ischemic stroke due to tandem occlusion: A meta-analysis of aggregate data | Background The periprocedural antithrombotic regimen might affect the risk-benefit profile of emergent carotid artery stenting (eCAS) in patients with acute ischemic stroke (AIS) due to tandem lesions, especially after intravenous thrombolysis. We conducted a systematic review and meta-analysis to evaluate the safety and efficacy of antithrombotics following eCAS. Methods We followed PRISMA guidelines and searched MEDLINE, Embase, and Scopus from January 1, 2004 to November 30, 2022 for studies evaluating eCAS in tandem occlusion. The primary endpoint was 90-day good functional outcome. Secondary outcomes were symptomatic intracerebral hemorrhage, in-stent thrombosis, delayed stent thrombosis, and successful recanalization. Meta-analysis of proportions and meta-analysis of odds ratios were implemented. Results 34 studies with 1658 patients were included. We found that the use of no antiplatelets (noAPT), single antiplatelet (SAPT), dual antiplatelets (DAPT), or glycoprotein IIb/IIIa inhibitors (GPI) yielded similar rates of good functional outcomes, with a marginal benefit of GPI over SAPT (OR 1.88, 95% CI 1.05 to 3.35, P heterogeneity =0.31). Sensitivity analysis and meta-regression excluded a significant impact of intravenous thrombolysis and Alberta Stroke Program Early CT Score (ASPECTS). We observed no increase in symptomatic intracerebral hemorrhage (sICH) with DAPT or GPI compared with noAPT or SAPT. We also found similar rates of delayed stent thrombosis across groups, with acute in-stent thrombosis showing marginal, non-significant benefits from GPI and DAPT over SAPT and noAPT. Conclusions In AIS due to tandem occlusion, the periprocedural antithrombotic regimen of eCAS seems to have a marginal effect on good functional outcome. Overall, high intensity antithrombotic therapy may provide a marginal benefit on good functional outcome and carotid stent patency without a significant increase in risk of sICH. © Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ. | Diana, Francesco; Abdalkader, Mohamad; Behme, Daniel; Li, Wei; Maurer, Christoph Johannes; Pop, Raoul; Hwang, Yang-Ha; Bartolini, Bruno; Da Ros, Valerio; Bracco, Sandra; Cirillo, Luigi; Marnat, Gaultier; Katsanos, Aristeidis H.; Kaesmacher, Johannes; Fischer, Urs; De Sousa, Diana Aguiar; Peschillo, Simone; Zini, Andrea; Tomasello, Alejandro; Ribo, Marc; Nguyen, Thanh N.; Romoli, Michele | Interventional Neuroradiology, Vall d'Hebron University Hospital, Catalunya, Barcelona, Spain, Stroke Research Group, Vall d'Hebron Research Institute, Catalunya, Barcelona, Spain; Radiology, Boston Medical Center, Boston, MA, United States; Neuroradiology, University Hospital Magdeburg, Sachsen-Anhalt, Magdeburg, Germany; Neurology, Hainan Medical University, Hainan, Haikou, China; Diagnostic and Interventional Neuroradiology, University Hospital Augsburg, Bayern, Augsburg, Germany; Interventional Neuroradiology, University Hospitals Strasbourg, Strasbourg, France; Neurology and Radiology, Kyungpook National University Hospital, Daegu, South Korea; Diagnostic and Interventional Radiology, Interventional Neuroradiology Unit, CHUV - Lausanne University Hospital, Lausanne, Switzerland; Biomedicine and Prevention, Diagnostic Imaging Unit, Fondazione PTV Policlinico Tor Vergata, Roma, Italy; Neurology and Human Movement Sciences, Interventional Neuroradiology Unit, Azienda Ospedaliera Universitaria Senese, Siena, Italy; Biomedical and NeuroMotor Sciences (DIBINEM), University of Bologna, Bologna, Italy; Interventional and Diagnostic Neuroradiology, Bordeaux University Hospital, Bordeaux, France; Neurology Division, McMaster University, Population Health Research Institute, Hamilton, ON, Canada; Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Neurosciences and Mental Health, Neurology Service, Hospital de Santa Maria, CHULN, University of Lisbon, Lisboa, Portugal; Endovascular Neurosurgery, Pia Fondazione Cardinale G Panico Hospital, Tricase, Italy, UniCamillus International Medical University, Rome, Italy; Neurology and Stroke Center, Maggiore Hospital, Bologna, Italy, IRCCS Istituto Delle Scienze Neurologiche di Bologna, Emilia-Romagna, Bologna, Italy; Interventional Neuroradiology, Vall d'Hebron University Hospital, Catalunya, Barcelona, Spain, Stroke Research Group, Vall d'Hebron Research Institute, Catalunya, Barcelona, Spain; Stroke Research Group, Vall d'Hebron Research Institute, Catalunya, Barcelona, Spain, Stroke Unit, Neurology, Vall d'Hebron University Hospital, Barcelona, Spain; Radiology, Boston Medical Center, Boston, MA, United States, Neurology, Boston University School of Medicine, Boston, MA, United States; Neurology and Stroke Unit, Maurizio Bufalini Hospital, Emilia-Romagna, Cesena, Italy | 57191078814; 55881763400; 56075716300; 59888749400; 57217265778; 56184864800; 7402311308; 37101148300; 54882945500; 35583674900; 35787008700; 57197760324; 55311611200; 54403165200; 7202827469; 55781226000; 8943681400; 57879430100; 57193889367; 7006988462; 59709574500; 56592186200 | francesco.diana.md@gmail.com; | Journal of NeuroInterventional Surgery | J NEUROINTERV SURG | 1759-8478 | 1759-8486 | 16 | 3 | SCIE | NEUROIMAGING;SURGERY | 2023 | 4.5 | 6.3 | 4.65 | 2025-06-25 | 18 | stent; stroke; thrombectomy; thrombolysis | Carotid Artery Diseases; Carotid Stenosis; Cerebral Hemorrhage; Fibrinolytic Agents; Humans; Ischemic Stroke; Platelet Aggregation Inhibitors; Retrospective Studies; Stents; Stroke; Thrombectomy; Thrombosis; Treatment Outcome; acetylsalicylic acid plus clopidogrel; anticoagulant agent; fibrinogen receptor antagonist; prostaglandin synthase inhibitor; purinergic receptor affecting agent; antithrombocytic agent; fibrinolytic agent; acute ischemic stroke; Alberta Stroke Program Early CT Score; anticoagulant therapy; Article; brain hemorrhage; brain infarction; carotid angioplasty; carotid artery stenting; carotid stenosis; cerebrovascular accident; clinical outcome; confidence interval; data analysis; data base; data extraction; drug efficacy; drug safety; dual antiplatelet therapy; emergent carotid artery stenting; fibrinolytic therapy; human; internal carotid artery occlusion; mechanical thrombectomy; meta analysis; neurologic disease assessment; odds ratio; practice guideline; Preferred Reporting Items for Systematic Reviews and Meta-Analyses; quality control; recanalization; sensitivity analysis; statistical analysis; stent thrombosis; systematic review; tandem occlusion; thrombectomy; brain hemorrhage; carotid artery disease; carotid stenosis; cerebrovascular accident; complication; diagnostic imaging; ischemic stroke; retrospective study; stent; thrombosis; treatment outcome | English | Final | 2023 | 10.1136/jnis-2023-020204 | 바로가기 | 바로가기 | 바로가기 | |||||||
| ○ | ○ | Article | On developing accurate prediction models for residual tensile strength of GFRP bars under alkaline-concrete environment using a combined ensemble machine learning methods | GFRP (Glass-fiber reinforced polymer) bars are recognized as a structural material enabling replace existing steel rebar. However, GFRP bars exhibit a decrease in tensile strength under severe conditions such as strong alkalinity, high salinity, and humid environment. Thus, a pre-dictive model for such GFRP tensile strength deterioration attempts to be developed, but model accuracy still needs improvement. Therefore, this paper proposes a more enhanced ensemble machine learning model to predict the residual tensile strength of GFRP bars accurately. For this end, tensile strength retention (TSR) experiment results of GFRP bars are utilized. Critical pa-rameters for GFRP TSR are diameter, fiber volume fraction, pH, temperature, and exposure time. Regarding the TSR prediction model of GFRP bar, single machine learning models such as mul-tiple linear regression, nonlinear regression, support vector machine, artificial neural network, and Gaussian process regression show 0.482-0.894 for training and 0.412-0.813 for testing, based on the accuracy of coefficient of determination (R2). Individual ensemble learning machine learning models of bagging and stacking show an accuracy of about 0.897 for training and 0.816 for testing. The proposed model shows an accuracy of about 0.912 for training and 0.834 for testing, which improves about 4-22% compared to previous study model performances. | Go, Chaeyeon; Kwak, Yun-Ji; Kwag, Shinyoung; Eem, Seunghyun; Lee, Sangwoo; Ju, Bu-Seog | Hanbat Natl Univ, Dept Civil & Environm Engn, Daejeon 34158, South Korea; Kyungpook Natl Univ, Sch Convers & Fus Syst Engn, Sangju, South Korea; Kyungpook Natl Univ, Major Plant Syst Engn, Sangju, South Korea; Kyung Hee Univ, Dept Civil Engn, Yongin 17104, Gyeonggi Do, South Korea | ; Eem, Seunghyun/KVB-1493-2024 | 58285501700; 58285449200; 55779491500; 52363442900; 57708839100; 55652548900 | skwag@hanbat.ac.kr;bju2@khu.ac.kr; | CASE STUDIES IN CONSTRUCTION MATERIALS | CASE STUD CONSTR MAT | 2214-5095 | 18 | SCIE | CONSTRUCTION & BUILDING TECHNOLOGY;ENGINEERING, CIVIL;MATERIALS SCIENCE, MULTIDISCIPLINARY | 2023 | 6.5 | 6.3 | 1.32 | 2025-06-25 | 9 | 9 | GFRP(Glass-fiber reinforced polymer) bar; Residual Tensile Strength; Ensemble Machine Learning; Bagging; Stacking | REINFORCING BARS; BOND STRENGTH; DURABILITY PREDICTION; MECHANICAL-PROPERTIES; TEMPERATURE; PERFORMANCE; BEAMS; FRP | Bagging; Ensemble Machine Learning; GFRP(Glass-fiber reinforced polymer) bar; Residual Tensile Strength; Stacking | Alkalinity; Deterioration; Forecasting; Glass fibers; Linear regression; Neural networks; Reinforcement; Steel fibers; Support vector machines; Bagging; Ensemble machine learning; Glass-fiber reinforced polymer bars; Glassfiber reinforced polymers (GFRP); Machine learning models; Machine-learning; Prediction modelling; Residual tensile strength; Stackings; Strength retention; Tensile strength | English | 2023 | 2023-07 | 10.1016/j.cscm.2023.e02157 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Sequential backward feature selection for optimizing permanent strain model of unbound aggregates | This study proposes a novel framework for identifying the optimal feature set required to predict the permanent strain of unbound aggregates. An experimental database consisting of 16 input features is preprocessed and the performance of 10 machine learning models is evaluated. The best-performing model is then paired with a sequential backward selection algorithm to determine the optimal feature set for predicting the permanent strain. Finally, the selected features are used to predict the permanent strain, and the performance is compared with those obtained from the principal components analysis. Six features are selected as the optimal feature set. Furthermore, the selected features accurately predict permanent strain with a root mean square error value of 0.014, which is smaller than those obtained from principal components analysis. Thus, the feature selection approach for machine learning models effectively predicts the permanent strain of unbound aggregates using a limited set of input features. | Aregbesola, Samuel Olamide; Won, Jongmuk; Kim, Seungjun; Byun, Yong-Hoon | Kyungpook Natl Univ, Sch Agr Civil & Bioind Engn, 80 Daehak Ro, Daegu 41566, South Korea; Univ Ulsan, Dept Civil & Environm Engn, Daehak Ro 93, Ulsan 44610, South Korea; Korea Univ, Sch Civil Environm & Architectural Engn, Seoul 02841, South Korea | Kim, Seungjun/R-3294-2019; Aregbesola, Samuel/LXV-8805-2024; Byun, Yong-Hoon/JKI-8441-2023 | 58631316600; 53878877200; 55498261300; 42761048000 | yhbyun@knu.ac.kr; | CASE STUDIES IN CONSTRUCTION MATERIALS | CASE STUD CONSTR MAT | 2214-5095 | 19 | SCIE | CONSTRUCTION & BUILDING TECHNOLOGY;ENGINEERING, CIVIL;MATERIALS SCIENCE, MULTIDISCIPLINARY | 2023 | 6.5 | 6.3 | 1.02 | 2025-06-25 | 6 | 7 | Aggregate; Feature selection; Machine learning; Optimization; Permanent strain | Aggregate; Feature selection; Machine learning; Optimization; Permanent strain | Feature Selection; Forecasting; Learning algorithms; Mean square error; Principal component analysis; Features selection; Input features; Machine learning models; Machine-learning; Optimal feature sets; Optimisations; Performance; Permanent strain; Principal-component analysis; Unbound aggregates; Aggregates | English | 2023 | 2023-12 | 10.1016/j.cscm.2023.e02554 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Tailored antiplatelet therapy in stent assisted coiling for unruptured aneurysms: a nationwide registry study | BackgroundAntiplatelet therapy, where regimens are tailored based on platelet function testing, has been introduced into neurointerventional surgery. This nationwide registry study evaluated the effect and safety of tailored antiplatelet therapy in stent assisted coiling for unruptured aneurysms compared with conventional therapy using a standard regimen. MethodsThis study enrolled 1686 patients in 44 participating centers who received stent assisted coiling for unruptured aneurysms between January 1, 2019 and December 31, 2019. The standard regimen (aspirin and clopidogrel) was used for all patients in the conventional group (924, 19 centers). The regimen was selected based on platelet function testing (standard regimen for clopidogrel responders; adding cilostazol or replacing clopidogrel with other thienopyridines (ticlopidine, prasugrel, or ticagrelor) for clopidogrel non-responders) in the tailored group (762, 25 centers). The primary outcome was thromboembolic events. Secondary outcomes were bleeding and poor outcomes (increase in modified Rankin Scale score). Outcomes within 30 days after coiling were compared using logistic regression analysis. ResultsThe thromboembolic event rate was lower in the tailored group than in the conventional group (30/762 (3.9%) vs 63/924 (6.8%), adjusted OR 0.560, 95% CI 0.359 to 0.875, P=0.001). The bleeding event rate was not different between the study groups (62/762 (8.1%) vs 73/924 (7.9%), adjusted OR 0.790, 95% CI 0.469 to 1.331, P=0.376). Poor outcomes were less frequent in the tailored group (12/762 (1.6%) vs 34 (3.7%), adjusted OR 0.252, 95% CI 0.112 to 0.568, P=0.001). ConclusionTailored antiplatelet therapy in stent assisted coiling for unruptured aneurysms reduced thromboembolic events and poor outcomes without increasing bleeding. | Koh, Jun Seok; Hwang, Gyojun; Park, Jung Cheol; Lee, Chang-Young; Chung, Joonho; Lee, Sang-Weon; Kwon, Hyon-Jo; Kim, Seong-Rim; Kang, Dong-Hun; Kwon, Soon Chan; Kim, Sung-Tae; Chang, Chul Hoon; Jang, Dong-Kyu; Choi, Jae Hyung; Kim, Young Woo; Kim, Bum-Tae; Shin, Byoung Gook; You, Seung Hoon; Chung, Seung Young; Ko, Junkyeung; Kim, Tae Gon; Yoon, Seok-Mann; Lee, Jong Young; Park, Hyun; Park, Jung Hyun; Cho, Jae-Hoon; Koo, Hae-Won; Sung, Jae Hoon; Rhee, Jinnie; Shin, Ho Gyun | Kyung Hee Univ, Kyung Hee Univ Hosp Gangdong, Dept Neurosurg, Sch Med, Seoul, South Korea; Bundang Jesaeng Gen Hosp, Daejin Med Ctr, Dept Neurosurg, Seongnam, Gyeonggi, South Korea; Univ Ulsan, Asan Med Ctr, Dept Neurosurg, Coll Med, Seoul, South Korea; Keimyung Univ, Dept Neurosurg, Dongsan Med Ctr, Daegu, South Korea; Yonsei Univ, Dept Neurosurg, Gangnam Severance Hosp, Seoul, South Korea; Pusan Natl Univ, Dept Neurosurg, Yangsan Hosp, Yangsan, Gyeongnam, South Korea; Chungnam Natl Univ Hosp, Reg Cerebrovascular Ctr, Dept Neurosurg, Daejeon, South Korea; Catholic Univ, Korea Bucheon St Marys Hosp, Dept Neurosurg, Bucheon, Gyeonggi, South Korea; Kyungpook Natl Univ Hosp, Dept Neurosurg, Daegu, South Korea; Ulsan Univ Hosp, Univ Ulsan Coll Med, Dept Neurosurg, Ulsan, South Korea; Inje Univ, Dept Neurosugery, Busan Paik Hosp, Busan, South Korea; Yeungnam Univ, Dept Neurosurg, Med Ctr, Daegu, South Korea; Catholic Univ Korea, Incheon St Marys Hosp, Coll Med, Dept Neurosurg, Incheon, South Korea; Dong A Univ Hosp, Dept Neurosurg, Busan, South Korea; Catholic Univ Korea, Uijeongbu St Marys Hosp, Dept Neurosurg, Uijeongbu St, Uijongbu, Gyeonggi, South Korea; Soonchunhyang Univ, Bucheon Hosp, Dept Neurosurg, Bucheon, Gyeonggi, South Korea; Dongeui Med Ctr, Dept Neurosurg, Busan, South Korea; Univ Ulsan, Gangneung Asan Hosp, Dept Neurosurg, Coll Med, Kangnung, Gangwon, South Korea; Daejeon Eulji Univ Hosp, Dept Neurosurg, Daejeon, South Korea; Pusan Natl Univ Hosp, Dept Neurosurg, Busan, South Korea; CHA Univ, CHA Bundang Med Ctr, Dept Neurosurg, Sch Med, Seongnam, Gyeonggi, South Korea; Soonchunhyang Univ, Dept Neurosurg, Cheonan Hosp, Cheonan, Chungnam, South Korea; Hallym Univ, Dept Neurosurg, Gangdong Sacred Heart Hosp, Seoul, South Korea; Gyeongsang Natl Univ, Gyeongsang Natl Univ Hosp, Dept Neurosurg, Sch Med, Jinju, Gyeongnam, South Korea; Hallym Univ, Dept Neurosurg, Dongtan Sacred Heart Hosp, Hwaseong, Gyeonggi, South Korea; Pohang SM Christianity Hosp, Dept Neurosurg, Pohang, Gyeongbuk, South Korea; Inje Univ, Dept Neurosurg, Ilsan Paik Hosp, Goyang, Gyeonggi, South Korea; Catholic Univ Korea, St Vincents Hosp, Dept Neurosurg, Suwon, Gyeonggi, South Korea; Natl Evidence based Healthcare Collaborating Agcy, Seoul, South Korea | ; Kim, Jae/C-5549-2012; SUNG, Jae Hoon/JMB-2400-2023 | 55784691900; 36126250800; 35148115900; 56658054500; 17134193400; 27168830200; 26647558700; 25629407500; 8977805800; 9436156800; 57196228769; 8849503500; 57723066000; 55844188900; 25951427700; 55972208500; 58661495900; 25723983500; 26667469800; 35205888000; 55696492500; 56323200700; 57196135871; 57212172160; 57202138476; 25722899600; 57188757135; 7402626856; 58661424000; 57219900089 | hwang.gyojun.md@gmail.com; | JOURNAL OF NEUROINTERVENTIONAL SURGERY | J NEUROINTERV SURG | 1759-8478 | 1759-8486 | 15 | 11 | SCIE | NEUROIMAGING;SURGERY | 2023 | 4.5 | 6.3 | 3.1 | 2025-06-25 | 12 | 13 | Aneurysm; Stent | ACUTE CORONARY SYNDROMES; ELEVATION MYOCARDIAL-INFARCTION; TREATMENT PLATELET REACTIVITY; DOSE PRASUGREL; CLOPIDOGREL; EMBOLIZATION; TICAGRELOR; JAPANESE; CONSENSUS; STANDARD | Aneurysm; Stent | Clopidogrel; Embolization, Therapeutic; Humans; Intracranial Aneurysm; Platelet Aggregation Inhibitors; Registries; Retrospective Studies; Stents; Thromboembolism; Treatment Outcome; acetylsalicylic acid; antithrombocytic agent; calcium channel blocking agent; cilostazol; clopidogrel; hydroxymethylglutaryl coenzyme A reductase inhibitor; nonsteroid antiinflammatory agent; prasugrel; proton pump inhibitor; ticagrelor; ticlopidine; antithrombocytic agent; clopidogrel; adult; Article; blood clotting parameters; cohort analysis; coil embolization; confidence interval; drug substitution; drug withdrawal; female; human; human cell; loading drug dose; logistic regression analysis; major clinical study; male; middle aged; odds ratio; patient registry; Rankin scale; retrospective study; thrombocyte function; thromboembolism; treatment outcome; unruptured intracranial aneurysm; artificial embolization; intracranial aneurysm; register; thromboembolism | English | 2023 | 2023-11 | 10.1136/jnis-2022-019571 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | DexBERT: Effective, Task-Agnostic and Fine-Grained Representation Learning of Android Bytecode | The automation of an increasingly large number of software engineering tasks is becoming possible thanks to Machine Learning (ML). One foundational building block in the application of ML to software artifacts is the representation of these artifacts (e.g., source code or executable code) into a form that is suitable for learning. Traditionally, researchers and practitioners have relied on manually selected features, based on expert knowledge, for the task at hand. Such knowledge is sometimes imprecise and generally incomplete. To overcome this limitation, many studies have leveraged representation learning, delegating to ML itself the job of automatically devising suitable representations and selections of the most relevant features. Yet, in the context of Android problems, existing models are either limited to coarse-grained whole-app level (e.g., apk2vec) or conducted for one specific downstream task (e.g., smali2vec). Thus, the produced representation may turn out to be unsuitable for fine-grained tasks or cannot generalize beyond the task that they have been trained on. Our work is part of a new line of research that investigates effective, task-agnostic, and fine-grained universal representations of bytecode to mitigate both of these two limitations. Such representations aim to capture information relevant to various low-level downstream tasks (e.g., at the class-level). We are inspired by the field of Natural Language Processing, where the problem of universal representation was addressed by building Universal Language Models, such as BERT, whose goal is to capture abstract semantic information about sentences, in a way that is reusable for a variety of tasks. We propose DexBERT, a BERT-like Language Model dedicated to representing chunks of DEX bytecode, the main binary format used in Android applications. We empirically assess whether DexBERT is able to model the DEX language and evaluate the suitability of our model in three distinct classlevel software engineering tasks: Malicious Code Localization, Defect Prediction, and Component Type Classification. We also experiment with strategies to deal with the problem of catering to apps having vastly different sizes, and we demonstrate one example of using our technique to investigate what information is relevant to a given task. | Sun, Tiezhu; Allix, Kevin; Kim, Kisub; Zhou, Xin; Kim, Dongsun; Lo, David; Bissyande, Tegawende F.; Klein, Jacques | Univ Luxembourg, L-1359 Kirchberg, Luxembourg; Singapore Management Univ, Singapore 188065, Singapore; Kyungpook Natl Univ, Daegu 41566, South Korea | Kim, Dongsun/B-4856-2015; LO, David/A-2493-2012; Lo, David/A-2493-2012; Allix, Kevin/AAF-3197-2021 | 57475581500; 56121446600; 57200368137; 57770923400; 55742964600; 35269388000; 36080354200; 56282553000 | tiezhu.sun@uni.lu;kevin.allix@uni.lu;kisubkim@smu.edu.sg;xinzhou.2020@phdcs.smu.edu.sg;darkrsw@gmail.com;davidlo@smu.edu.sg;tegawende.bissyande@uni.lu;jacques.klein@uni.lu; | IEEE TRANSACTIONS ON SOFTWARE ENGINEERING | IEEE T SOFTWARE ENG | 0098-5589 | 1939-3520 | 49 | 10 | SCIE | COMPUTER SCIENCE, SOFTWARE ENGINEERING;ENGINEERING, ELECTRICAL & ELECTRONIC | 2023 | 6.5 | 6.4 | 1.12 | 2025-06-25 | 4 | 11 | Representation learning; Android app analysis; code representation; malicious code localization; defect prediction | MALWARE DETECTION; DEFECT PREDICTION; MALICIOUS CODE; PERFORMANCE; FRAMEWORK | Android app analysis; code representation; defect prediction; malicious code localization; Representation learning | Android (operating system); Android malware; Codes (symbols); Computer software reusability; Curricula; Engineering education; Job analysis; Learning systems; Natural language processing systems; Object oriented programming; Semantics; Android app analyse; Android apps; Code; Code representation; Defect prediction; Localisation; Location awareness; Malicious code localization; Malicious codes; Malwares; Operating system; Predictive models; Representation learning; Task analysis; Application programs | English | 2023 | 2023-10-01 | 10.1109/tse.2023.3310874 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Dual Impact of IGF2 on Alveolar Stem Cell Function during Tobacco-Induced Injury Repair and Development of Pulmonary Emphysema and Cancer | Pulmonary emphysema is a destructive inflammatory disease primarily caused by cigarette smoking (CS). Recovery from CS -induced injury requires proper stem cell (SC) activities with a tightly controlled balance of proliferation and differentiation. Here we show that acute alveolar injury induced by two representative tobacco carcinogens, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo[a]pyrene (N/B), increased IGF2 expression in alveolar type 2 (AT2) cells to promote their SC function and facilitate alveolar regeneration. Autocrine IGF2 signaling upregulated Wnt genes, particularly Wnt3, to stimulate AT2 proliferation and alveolar barrier regeneration after N/B-induced acute injury. In contrast, repetitive N/B exposure provoked sustained IGF2-Wnt signaling through DNMT3A-mediated epigenetic control of IGF2 expression, causing a proliferation/differentiation imbalance in AT2s and development of emphysema and cancer. Hypermethylation of the IGF2 promoter and overexpression of DNMT3A, IGF2, and the Wnt target gene AXIN2 were seen in the lungs of patients with CS-associated emphysema and cancer. Pharmacologic or genetic approaches targeting IGF2-Wnt signaling or DNMT prevented the development of N/B-induced pulmonary diseases. These findings support dual roles of AT2 cells, which can either stimulate alveolar repair or promote emphysema and cancer depending on IGF2 expression levels. | Boo, Hye-Jin; Min, Hye-Young; Park, Choon-Sik; Park, Jong-Sook; Jeong, Ji Yun; Lee, Shin Yup; Kim, Woo -Young; Lee, Jae -Won; Oh, Sei-Ryang; Park, Rang-Woon; Lee, Ho -Young | Seoul Natl Univ, Coll Pharm, Creat Res Initiat Ctr Concurrent Control Emphysema, Seoul, South Korea; Seoul Natl Univ, Coll Pharm, Seoul, South Korea; Seoul Natl Univ, Res Inst Pharmaceut Sci, Seoul, South Korea; Soonchunhyang Univ, Bucheon Hosp, Bucheon Si, Gyeonggi Do, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Pathol, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Lung Canc Ctr, Sch Med,Dept Internal Med, Daegu, South Korea; Sookmyung Womens Univ, Coll Pharm, Seoul, South Korea; Korea Res Inst Biosci & Biotechnol, Nat Med Res Ctr, Cheongju, Chungcheongbug, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biochem & Cell Biol, Daegu, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, Daegu, South Korea; Jeju Natl Univ, Coll Med, Jeju, Jeju Special Se, South Korea; Seoul Natl Univ, Coll Pharm, 1 Gwanak Ro, Seoul 08826, South Korea | Lee, Sun-Ho/AAD-6712-2022; KIM, SUNJONG/JXN-0257-2024; Lee, Jae-Hyun/ABE-3803-2020 | 35482970400; 56564751200; 7408415097; 56135326200; 57205472984; 49863712700; 7405810419; 55949799600; 55573210200; 7401895636; 57049822900 | hylee135@snu.ac.kr; | CANCER RESEARCH | CANCER RES | 0008-5472 | 1538-7445 | 83 | 11 | SCIE | ONCOLOGY | 2023 | 12.5 | 6.4 | 0.91 | 2025-06-25 | 5 | 7 | LUNG DEVELOPMENT; PROLIFERATION; REGENERATION; EXPRESSION; DISEASE; COPD; PROGRESSION; ACTIVATION; MECHANISMS; PROGENITOR | Emphysema; Humans; Insulin-Like Growth Factor II; Lung; Neoplasms; Pulmonary Emphysema; Stem Cells; Tobacco; IGF2 protein, human; somatomedin B; emphysema; genetics; human; lung; lung emphysema; metabolism; neoplasm; pathology; stem cell; tobacco | English | 2023 | 2023-06-01 | 10.1158/0008-5472.can-22-3543 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Review | Progress and outlook of Sn-Pb mixed perovskite solar cells | Organic-inorganic hybrid perovskites have revolutionized solar cell research owing to their excellent material properties. Most previous research has been done on Pb-based perovskites. Recently, efforts to discover a Pb-free or Pb-less perovskite material with an ideal bandgap ranging 1.1-1.3 eV have led researchers to investigate Sn-Pb mixed perovskites. Sn-Pb mixed perovskites have a bandgap of similar to 1.25 eV, which is suitable for high-efficiency single-junction and perovskite/perovskite tandem solar cells. Moreover, the Pb content of Sn-Pb mixed perovskites is 50-60% lower than that of Pb-based perovskites, partially mitigating the Pb toxicity issue. However, incorporating Sn2+ into the crystal structure also causes various drawbacks, such as inhomogeneous thin film morphologies, easy oxidation of Sn2+, and more vulnerable surface properties. Researchers have made substantial progress in addressing these challenges through improvements in compositional design, structural optimization, precursor design, and surface treatments. In this review, we provide a comprehensive overview of the progress in Sn-Pb mixed perovskite solar cells. Furthermore, we analyze the key variables and trends as well as provide an outlook for future directions in the research on Sn-Pb mixed perovskites. | Lee, Hyemin; Kang, Seok Beom; Lee, Sangwook; Zhu, Kai; Kim, Dong Hoe | Korea Univ, Dept Mat Sci & Engn, Seoul 02841, South Korea; Kyungpook Natl Univ, Sch Mat Sci & Engn, Daegu 41566, South Korea; Natl Renewable Energy Lab, Chem & Nanosci Ctr, Golden, CO 80401 USA | Kim, Dong Hoe/HLQ-5764-2023; Zhu, Kai/AAF-1940-2019; Kang, Seok Beom/HGA-0547-2022; Lee, Sangwook/O-9166-2015 | 57218340449; 57216319784; 57203597324; 57200759254; 56366898500 | wook2@knu.ac.kr;kai.zhu@nrel.gov;donghoekim@korea.ac.kr; | NANO CONVERGENCE | NANO CONVERG | 2196-5404 | 10 | 1 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY;PHYSICS, APPLIED | 2023 | 13.5 | 6.4 | 1 | 2025-06-25 | 24 | 24 | Sn-Pb mixed perovskite; Narrow bandgap; Low bandgap; Mixed tin-lead; Perovskite solar cells; Tandem solar cells | HALIDE PEROVSKITES; CARRIER LIFETIMES; TIN; EFFICIENCY; IODIDE; ABSORBERS; STABILITY; BEHAVIOR | Low bandgap; Mixed tin–lead; Narrow bandgap; Perovskite solar cells; Sn–Pb mixed perovskite; Tandem solar cells | English | 2023 | 2023-06-16 | 10.1186/s40580-023-00371-9 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Prostate Cancer Progression Relies on the Mitotic Kinase Citron Kinase | The poorly characterized protein kinase citron kinase is a therapeutic target in prostate cancer that drives tumor growth by regulating diverse substrates, which control several hallmarks of aggressive prostate cancer progression. Prostate cancer remains the second leading cause of cancer death in men in Western cultures. A deeper understanding of the mechanisms by which prostate cancer cells divide to support tumor growth could help devise strategies to overcome treatment resistance and improve survival. Here, we identified that the mitotic AGC family protein kinase citron kinase (CIT) is a pivotal regulator of prostate cancer growth that mediates prostate cancer cell interphase progression. Increased CIT expression correlated with prostate cancer growth induction and aggressive prostate cancer progression, and CIT was overexpressed in prostate cancer compared with benign prostate tissue. CIT overexpression was controlled by an E2F2-Skp2-p27 signaling axis and conferred resistance to androgen-targeted treatment strategies. The effects of CIT relied entirely on its kinase activity. Conversely, CIT silencing inhibited the growth of cell lines and xenografts representing different stages of prostate cancer progression and treatment resistance but did not affect benign epithelial prostate cells or nonprostatic normal cells, indicating a potential therapeutic window for CIT inhibition. CIT kinase activity was identified as druggable and was potently inhibited by the multikinase inhibitor OTS-167, which decreased the proliferation of treatment-resistant prostate cancer cells and patient-derived organoids. Isolation of the in vivo CIT substrates identified proteins involved in diverse cellular functions ranging from proliferation to alternative splicing events that are enriched in treatment-resistant prostate cancer. These findings provide insights into the regulation of aggressive prostate cancer cell behavior by CIT and identify CIT as a functionally diverse and druggable driver of prostate cancer progression.Significance: The poorly characterized protein kinase citron kinase is a therapeutic target in prostate cancer that drives tumor growth by regulating diverse substrates, which control several hallmarks of aggressive prostate cancer progression. See related commentary by Mishra et al., p. 4008Significance: The poorly characterized protein kinase citron kinase is a therapeutic target in prostate cancer that drives tumor growth by regulating diverse substrates, which control several hallmarks of aggressive prostate cancer progression. See related commentary by Mishra et al., p. 4008 | Rawat, Chitra; Ben-Salem, Salma; Singh, Nidhi; Chauhan, Gaurav; Rabljenovic, Anja; Vaghela, Vishwa; Venkadakrishnan, Varadha Balaji; Macdonald, Jonathan D.; Dahiya, Ujjwal R.; Ghanem, Yara; Bachour, Salam; Su, Yixue; Depriest, Adam D.; Lee, Sanghee; Muldong, Michelle; Kim, Hyun-Tae; Kumari, Sangeeta; Valenzuela, Malyn May; Zhang, Dingxiao; Hu, Qiang; Cortes Gomez, Eduardo; Dehm, Scott M.; Zoubeidi, Amina; Jamieson, Christina A. M.; Nicolas, Marlo; Mckenney, Jesse; Willard, Belinda; Klein, Eric A.; Magi-Galluzzi, Cristina; Stauffer, Shaun R.; Liu, Song; Heemers, Hannelore V. | Cleveland Clin, Dept Canc Biol, Cleveland, OH 44103 USA; Cleveland State Univ, Dept Biol Geol & Environm Sci, Cleveland, OH USA; Cleveland Clin, Ctr Therapeut Discovery, Mellen Ctr, Cleveland, OH USA; Cleveland Clin, Lerner Coll Med, Cleveland, OH USA; Roswell Pk Comprehens Canc Ctr, Dept Canc Genet, Buffalo, NY USA; UC San Diego Hlth, Dept Urol, La Jolla, CA 92121 USA; Kyungpook Natl Univ, Sch Med, Dept Urol, Daegu, South Korea; Roswell Pk Comprehens Canc Ctr, Dept Biostat & Bioinformat, Buffalo, NY USA; Hunan Univ, Sch Biomed Sci, Changsha 410082, Peoples R China; Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN 55455 USA; Univ Minnesota, Dept Lab Med, Minneapolis, MN USA; Univ Minnesota, Dept Pathol & Urol, Minneapolis, MN USA; Univ British Columbia, Vancouver Prostate Ctr, Dept Urol Sci, Vancouver, BC, Canada; Cleveland Clin, Dept Anat Pathol, Cleveland, OH USA; Cleveland Clin, Prote Core Facil, Cleveland, OH USA; Dept Urol, Cleveland Clin, Cleveland, OH USA; Cleveland Clin, Lerner Res Inst, DeptCancer Biol, NB-40, 9500 Euclid Ave, Cleveland, OH 44195 USA | ; Ben-Salem, Salma/E-1702-2016; Zhang, Dingxiao/A-1902-2016; Ben Salem, Salma/E-1702-2016; Kim, Kyu/E-7814-2012; Rawat, Chitra/IQW-5747-2023; Chauhan, Gaurav/KGL-3704-2024; Cortes, Eduardo/AAW-8005-2021; Hu, Qiang/AAJ-9438-2020; CHAUHAN, GAURAV/KGL-3704-2024 | 9942482900; 41360912400; 56608459100; 59282347800; 57217632435; 58768948300; 57190396631; 57202460333; 56145897400; 58769161500; 56866407900; 57205745284; 54392684000; 55940282600; 56020470100; 55739531300; 57195989011; 55414334200; 25937062100; 54581035900; 57190377896; 6602529836; 22959316000; 7006413274; 7102810677; 7004450437; 7004704990; 7402149579; 6602741015; 36635153000; 26643557300; 6506641081 | heemerh@ccf.org; | CANCER RESEARCH | CANCER RES | 0008-5472 | 1538-7445 | 83 | 24 | SCIE | ONCOLOGY | 2023 | 12.5 | 6.4 | 0.76 | 2025-06-25 | 7 | 5 | ANDROGEN RECEPTOR; CELL-CYCLE; RHO; P27; EXPRESSION; INHIBITOR; RAS; PHOSPHORYLATION; TRANSCRIPTION; CYTOKINESIS | Cell Line, Tumor; Cell Proliferation; Humans; Male; Prostate; Prostatic Neoplasms; Protein Kinases; Signal Transduction; apitolisib; dacomitinib; doxycycline; mitotic kinase citron kinase; ots 167; protein inhibitor; protein p27; protein serine threonine kinase; S phase kinase associated protein 2; tofacitinib; transcription factor E2F2; unclassified drug; y 39983; protein kinase; alternative RNA splicing; animal cell; animal experiment; animal model; antiproliferative activity; Article; cancer growth; cancer resistance; cell function; cell proliferation; cell viability; coimmunoprecipitation; controlled study; human; human cell; human tissue; immunohistochemistry; in vivo study; interphase; male; mouse; nonhuman; prostate cancer; prostate tissue; prostate tumor; protein analysis; protein expression; protein function; protein targeting; real time polymerase chain reaction; regulatory mechanism; RNA sequencing; signal transduction; Western blotting; genetics; metabolism; pathology; prostate; prostate tumor; tumor cell line | English | 2023 | 2023-12-15 | 10.1158/0008-5472.can-23-0883 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Recombinant protein embedded liposome on gold nanoparticle based on LSPR method to detect Corona virus | Antibody sensor to detect viruses has been widely used but has problems such as the difficulty of right direction control of the receptor site on solid substrate, and long time and high cost for design and production of antibodies to new emerging viruses. The virus detection sensor with a recombinant protein embedded liposome (R/Li) was newly developed to solve the above problems, in which R/Li was assembled on AuNPs (Au@R/Li) to increase the sensitivity using localized surface plasmon resonance (LSPR) method. Recombinant angiotensin-converting enzyme-2 (ACE2) was used as host receptors of SARS-CoV and SARS-CoV-2, and the direction of enzyme active site for virus attachment could be controlled by the integration with liposome. The recombinant protein embedded liposomes were assembled on AuNPs, and LSPR method was used for detection. With the sensor platform S1 protein of both viruses was detected with detection limit of 10 pg/ml and SARS-CoV-2 in clinical samples was detected with 10 similar to 35 Ct values. In the selectivity test, MERS-CoV did not show a signal due to no binding with Au@R/Li. The proposed sensor platform can be used as promising detection method with high sensitivity and selectivity for the early and simple diagnosis of new emerging viruses. | Kim, Lina; Jo, Seongjae; Kim, Gyeong-Ji; Kim, Kyung Ho; Seo, Sung Eun; Ryu, Eunsu; Shin, Chan Jae; Kim, Yu Kyung; Choi, Jeong-Woo; Kwon, Oh Seok | Korea Res Inst Biosci & Biotechnol KRIBB, Infect Dis Res Ctr, Daejeon 34141, South Korea; Sogang Univ, Dept Chem & Biomol Engn, Seoul 04107, South Korea; Kyungpook Natl Univ, Sch Med, Dept Clin Pathol, Daegu 41944, South Korea; Sungkyunkwan Univ SKKU, SKKU Adv Inst Nanotechnol SAINT, Suwon 16419, South Korea; Sungkyunkwan Univ SKKU, Dept Nano Sci & Technol, Suwon 16419, South Korea; Sungkyunkwan Univ SKKU, Dept Nano Engn, Suwon 16419, South Korea | Jo, Seongjae/HTN-4673-2023; Shin, Chan Jae/MCX-9369-2025 | 57737028500; 57195684614; 58829777400; 57226848520; 57208651527; 58086605600; 58087021500; 9237571900; 26221078100; 7402195808 | jwchoi@sogang.ac.kr;oskwon79@skku.edu; | NANO CONVERGENCE | NANO CONVERG | 2196-5404 | 10 | 1 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY;PHYSICS, APPLIED | 2023 | 13.5 | 6.4 | 0.87 | 2025-06-25 | 7 | 7 | Virus sensor; Protein embedded liposome; Recombinant protein; SARS-CoV-2 detection; LSPR | SOFTWARE NEWS; IDENTIFICATION; SARS-COV-2; GUI | LSPR; Protein embedded liposome; Recombinant protein; SARS-CoV-2 detection; Virus sensor | English | 2023 | 2023-10-30 | 10.1186/s40580-023-00399-x | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | 2D gradient and correlation FTIR analyses for optimizing thermal curing process of commercial-grade polyurethane coatings for automotive interior parts | Soft-feel coatings for automotive interior parts are a crucial factor in consumer purchase preferences owing to the growing awareness of human sensibility ergonomics. Herein, the thermal curing of commercial-grade polyurethane (PU) coatings was optimized using advanced spectroscopic tools. Conventional FTIR spectra were collected at various curing temperatures and times, and analyzed using two-dimensional (2D) gradient maps and 2D correlation spectroscopy (2D COS); while the former demonstrates the spectral variation trend with curing time, the latter provides whole spectral sequences that inform the cure reaction mechanism. The thermal curing continued for 50 min at 60 and 70 degrees C, and was halted after 30 min above 80 degrees C. According to the 2D COS and kinetic model fitting, the cure reaction was initiated by solvent evaporation and followed nucleation and growth mechanisms. PUs cured at lower temperatures were ductile owing to incomplete reactions, whereas PUs cured above 80 degrees C exhibited brittle features. Consequently, the optimal curing process was determined to be at 80 degrees C for 30 min. The 2D FTIR analytic tools can be useful in the development of high-quality soft-feel coatings for automotive interior parts. | Kim, Minji; Seo, Jaesik; Park, Chanwook; Jeong, Ji Hun; Kim, Hyo Jeong; Chae, Doog Wook; Eom, Youngho | Pukyong Natl Univ, Dept Polymer Engn, Busan 48513, South Korea; Hyundai Motor Co, Mat Res & Engn Ctr, Sustainable Mat Res Team, Uiwang 16082, South Korea; Kyungpook Natl Univ, Dept Text Engn, Sangju 37224, South Korea | ; Eom, Youngho/U-6387-2019; SEO, JAE/AAO-5311-2020 | 59545008500; 24767941300; 58086073900; 57222354813; 58923640700; 7006246752; 56108103900 | eomyh@pknu.ac.kr; | PROGRESS IN ORGANIC COATINGS | PROG ORG COAT | 0300-9440 | 1873-331X | 185 | SCIE | CHEMISTRY, APPLIED;MATERIALS SCIENCE, COATINGS & FILMS | 2023 | 6.5 | 6.5 | 0.25 | 2025-06-25 | 2 | 2 | Polyurethane coating; Automotive interior parts; Thermal curing; Two-dimensional gradient map; Two-dimensional correlation spectroscopy | REACTION-KINETICS; PET | Automotive interior parts; Polyurethane coating; Thermal curing; Two-dimensional correlation spectroscopy; Two-dimensional gradient map | Coatings; Curing; Ergonomics; Polyurethanes; Purchasing; Automotive interior part; Automotive interiors; Curing process; FTIR; Gradient map; Polyurethane coatings; Thermal curing; Two-dimensional; Two-dimensional correlation spectroscopy; Two-dimensional gradient map; Fourier transform infrared spectroscopy | English | 2023 | 2023-12 | 10.1016/j.porgcoat.2023.107896 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Article | Efficient N-Type Organic Electrochemical Transistors and Field-Effect Transistors Based on PNDI-Copolymers Bearing Fluorinated Selenophene-Vinylene-Selenophenes | n-Type organic electrochemical transistors (OECTs) and organic field-effect transistors (OFETs) are less developed than their p-type counterparts. Herein, polynaphthalenediimide (PNDI)-based copolymers bearing novel fluorinated selenophene-vinylene-selenophene (FSVS) units as efficient materials for both n-type OECTs and n-type OFETs is reported. The PNDI polymers with oligo(ethylene glycol) (EG7) side chains P(NDIEG7-FSVS), afford a high & mu;C* of > 0.2 F cm-1V-1s-1, outperforming the benchmark n-type Pg4NDI-T2 and Pg4NDI-gT2 by two orders of magnitude. The deep-lying LUMO of -4.63 eV endows P(NDIEG7-FSVS) with an ultra-low threshold voltage of 0.16 V. Moreover, the conjugated polymer with octyldodecyl (OD) side chains P(NDIOD-FSVS) exhibits a surprisingly low energetic disorder with an Urbach energy of 36 meV and an ultra-low activation energy of 39 meV, resulting in high electron mobility of up to 0.32 cm(2) V-1 s(-1) in n-type OFETs. These results demonstrate the great potential for simultaneously achieving a lower LUMO and a tighter intermolecular packing for the next-generation efficient n-type organic electronics. | Kim, Jongho; Ren, Xinglong; Zhang, Youcheng; Fazzi, Daniele; Manikandan, Suraj; Andreasen, Jens Wenzel; Sun, Xiuming; Ursel, Sarah; Un, Hio-Ieng; Peralta, Sebastien; Xiao, Mingfei; Town, James; Marathianos, Arkadios; Roesner, Stefan; Bui, Thanh-Tuan; Ludwigs, Sabine; Sirringhaus, Henning; Wang, Suhao | CY Cergy Paris Univ, Lab Physicochim Polymeres & Interfaces, 5 Mail Gay Lussac, F-95000 Neuville sur oise, France; Univ Cambridge, Cavendish Lab, Optoelect Grp, JJ Thomson Ave, Cambridge CB3 0HE, England; Univ Bologna, Dipartimento Chim Giacomo Ciamician, Via F Selmi 2, I-40126 Bologna, Italy; Tech Univ Denmark, Dept Energy Convers & Storage, DK-2800 Lyngby, Denmark; Univ Stuttgart, Inst Polymer Chem, IPOC Funct Polymers, Pfaffenwaldring 55, D-70569 Stuttgart, Germany; Univ Stuttgart, Ctr Integrated Quantum Sci & Technol IQST, Pfaffenwaldring 55, D-70569 Stuttgart, Germany; Univ Warwick, Dept Chem, Gibbet Hill Rd, Coventry CV4 7AL, England; Kyungpook Natl Univ, Dept Text Syst Engn, Daegu 41566, South Korea | , 孙/AGX-5598-2022; WANG, Suhao/ITT-4571-2023; Un, Hio-Ieng/LXV-6176-2024; Kim, Jongho/AAV-3501-2020; Roesner, Stefan/AAI-7729-2021; Fazzi, Daniele/C-3297-2013; Zhang, Youcheng/MNO-2544-2025; Sirringhaus, Henning/ABD-1555-2021; Bui, Thanh-Tuan/E-4314-2010; Manikandan, Suraj/MSY-7140-2025; Andreasen, Jens/F-4634-2014; Andreasen, Jens Wenzel/F-4634-2014 | hs220@cam.ac.uk;suhao.wang1@cyu.fr; | ADVANCED SCIENCE | ADV SCI | 2198-3844 | 10 | 29 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY | 2023 | 14.3 | 6.5 | 17 | intermolecular packing; mixed ionic-electronic conductors; n-type conjugated polymers; organic electrochemical transistors; organic field-effect transistors | HIGH-MOBILITY; CONJUGATED POLYMERS; CHARGE-TRANSPORT; PERFORMANCE; DISORDER; DENSITY; ORIGIN | English | 2023 | 2023-10 | 10.1002/advs.202303837 | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | ○ | Article | Heterogeneous Integration of Freestanding Bilayer Oxide Membrane for Multiferroicity | Transition metal oxides exhibit a plethora of electrical and magnetic properties described by their order parameters. In particular, ferroic orderings offer access to a rich spectrum of fundamental physics phenomena, in addition to a range of technological applications. The heterogeneous integration of ferroelectric and ferromagnetic materials is a fruitful way to design multiferroic oxides. The realization of freestanding heterogeneous membranes of multiferroic oxides is highly desirable. In this study, epitaxial BaTiO3/La0.7Sr0.3MnO3 freestanding bilayer membranes are fabricated using pulsed laser epitaxy. The membrane displays ferroelectricity and ferromagnetism above room temperature accompanying the finite magnetoelectric coupling constant. This study reveals that a freestanding heterostructure can be used to manipulate the structural and emergent properties of the membrane. In the absence of the strain caused by the substrate, the change in orbital occupancy of the magnetic layer leads to the reorientation of the magnetic easy-axis, that is, perpendicular magnetic anisotropy. These results of designing multiferroic oxide membranes open new avenues to integrate such flexible membranes for electronic applications. | Kang, Kyeong Tae; Corey, Zachary J.; Hwang, Jaejin; Sharma, Yogesh; Paudel, Binod; Roy, Pinku; Collins, Liam; Wang, Xueijing; Lee, Joon Woo; Oh, Yoon Seok; Kim, Yeonhoo; Yoo, Jinkyoung; Lee, Jaekwang; Htoon, Han; Jia, Quanxi; Chen, Aiping | Los Alamos Natl Lab, Ctr Integrated Nanotechnol, Los Alamos, NM 87545 USA; Kyungpook Natl Univ, Dept Phys, Daegu 41566, South Korea; SUNY Buffalo, Univ Buffalo, Dept Mat Design & Innovat, Buffalo, NY 14260 USA; Pusan Natl Univ, Dept Phys, Busan 46241, South Korea; Oak Ridge Natl Lab, Ctr Nanophase Mat Sci, Oak Ridge, TN 37831 USA; Ulsan Natl Inst Sci & Technol, Dept Phys, Ulsan 44919, South Korea; Korea Res Inst Stand & Sci KRISS, Interdisciplinary Mat Measurement Inst, Daejeon 34133, South Korea | Paudel, Binod/AGG-6627-2022; Oh, Yoon/A-1071-2011; Chen, Aiping/F-3212-2011; Jia, Quanxi/Q-5614-2019; Sharma, Dr. Yogesh/GMW-5571-2022; Htoon, Han/HGF-0637-2022; Yoo, Jinkyoung/B-5291-2008 | 56002123900; 57423635300; 58176189600; 57212906820; 57208564825; 57199145396; 55348149200; 57202370307; 57221165324; 58254043900; 57190740415; 8561080400; 55888626200; 6602765519; 7102029237; 55265473100 | ktkang@knu.ac.kr;apchen@lanl.gov; | ADVANCED SCIENCE | ADV SCI | 2198-3844 | 10 | 15 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY | 2023 | 14.3 | 6.5 | 1.31 | 2025-06-25 | 10 | 10 | freestanding oxide membranes; magnetic anisotropy reorientation; magnetoelectric coupling; multiferroics | MAGNETIC-ANISOTROPY; THIN-FILMS; STRAIN; EVOLUTION | freestanding oxide membranes; magnetic anisotropy reorientation; magnetoelectric coupling; multiferroics | Barium titanate; Ferroelectric materials; Ferroelectricity; Ferromagnetic materials; Ferromagnetism; Magnetic anisotropy; Transition metal oxides; Transition metals; Bi-layer; Electrical and magnetic property; Freestanding oxide membrane; Heterogeneous integration; Magnetic anisotropy reorientation; Magnetoelectric couplings; Multiferroics; Order parameter; Oxide membrane; Transition-metal oxides; Membranes | English | 2023 | 2023-05 | 10.1002/advs.202207481 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Identification of Histone Lysine Acetoacetylation as a Dynamic Post-Translational Modification Regulated by HBO1 | Ketone bodies have long been known as a group of lipid-derived alternative energy sources during glucose shortages. Nevertheless, the molecular mechanisms underlying their non-metabolic functions remain largely elusive. This study identified acetoacetate as the precursor for lysine acetoacetylation (Kacac), a previously uncharacterized and evolutionarily conserved histone post-translational modification. This protein modification is comprehensively validated using chemical and biochemical approaches, including HPLC co-elution and MS/MS analysis using synthetic peptides, Western blot, and isotopic labeling. Histone Kacac can be dynamically regulated by acetoacetate concentration, possibly via acetoacetyl-CoA. Biochemical studies show that HBO1, traditionally known as an acetyltransferase, can also serve as an acetoacetyltransferase. In addition, 33 Kacac sites are identified on mammalian histones, depicting the landscape of histone Kacac marks across species and organs. In summary, this study thus discovers a physiologically relevant and enzymatically regulated histone mark that sheds light on the non-metabolic functions of ketone bodies. | Gao, Yan; Sheng, Xinlei; Tan, Doudou; Kim, SunJoo; Choi, Soyoung; Paudel, Sanjita; Lee, Taeho; Yan, Cong; Tan, Minjia; Kim, Kyu Min; Cho, Sam Seok; Ki, Sung Hwan; Huang, He; Zhao, Yingming; Lee, Sangkyu | Kyungpook Natl Univ, Coll Pharm, Daegu 41566, South Korea; Univ Chicago, Ben May Dept Canc Res, Chicago, IL 60637 USA; Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; Chosun Univ, Coll Pharm, Gwangju 61452, South Korea; Univ Chinese Acad Sci, Beijing 100049, Peoples R China; Sungkyunkwan Univ, Sch Pharm, Suwon 16419, South Korea; Chosun Univ, Coll Nat Sci, Dept Biomed Sci, Gwangju 61452, South Korea | ; kim, kyumin/KDN-4319-2024 | 58736921100; 57191831079; 57956725700; 57051715600; 57202918688; 57203320448; 57204032003; 57222267566; 36027735400; 56441871900; 57189215724; 8346836500; 57215153279; 7407404510; 57209046767 | hhuang@simm.ac.cn;yingming.zhao@uchicago.edu;sangkyu@skku.edu; | ADVANCED SCIENCE | ADV SCI | 2198-3844 | 10 | 25 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY | 2023 | 14.3 | 6.5 | 2.04 | 2025-06-25 | 13 | 15 | acetoacetate; acetoacetylation; epigenetics; HBO1; histone marks; novel histone modification | METABOLIC-REGULATION; GENE-EXPRESSION | acetoacetate; acetoacetylation; epigenetics; HBO1; histone marks; novel histone modification | Acetoacetates; Animals; Histones; Lysine; Mammals; Protein Processing, Post-Translational; Tandem Mass Spectrometry; Chemical modification; Ketones; Mammals; Metabolism; Proteins; acetoacetic acid; histone; lysine; Acetoacetates; Acetoacetylation; Alternative energy source; Epigenetics; Histone mark; Histone modification; Ketone bodies; Metabolic function; Novel histone modification; Post-translational modifications; animal; chemistry; genetics; mammal; metabolism; protein processing; tandem mass spectrometry; Amino acids | English | 2023 | 2023-09 | 10.1002/advs.202300032 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Machine Learning Attacks-Resistant Security by Mixed-Assembled Layers-Inserted Graphene Physically Unclonable Function | Mixed layers of octadecyltrichlorosilane (ODTS) and 1H,1H,2H,2H-perfluorooctyltriethoxysilane (FOTS) on an active layer of graphene are used to induce a disordered doping state and form a robust defense system against machine-learning attacks (ML attacks). The resulting security key is formed from a 12 x 12 array of currents produced at a low voltage of 100 mV. The uniformity and inter-Hamming distance (HD) of the security key are 50.0 & PLUSMN; 12.3% and 45.5 & PLUSMN; 16.7%, respectively, indicating higher security performance than other graphene-based security keys. Raman spectroscopy confirmed the uniqueness of the 10,000 points, with the degree of shift of the G peak distinguishing the number of carriers. The resulting defense system has a 10.33% ML attack accuracy, while a FOTS-inserted graphene device is easily predictable with a 44.81% ML attack accuracy. | Lee, Subin; Jang, Byung Chul; Kim, Minseo; Lim, Si Heon; Ko, Eunbee; Kim, Hyun Ho; Yoo, Hocheon | Gachon Univ, Dept Elect Engn, 1342 Seongnam Daero, Seongnam 13120, South Korea; Kyungpook Natl Univ, Sch Elect Engn, 80 Daehakro, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Elect & Elect Engn, 80 Daehakro, Daegu 41566, South Korea; Kumoh Natl Inst Technol, Dept Energy Engn Convergence, 61 Daehakro, Gumi Si 39177, Gumi, South Korea; Kumoh Natl Inst Technol, Sch Mat Sci & Engn, 61 Daehakro, Gumi Si 39177, Gumi, South Korea | Kim, Hyunho/GQH-5608-2022; Jang, Byung Chul/GYV-0656-2022; Yoo, Hocheon/ABZ-6637-2022 | 57252680900; 9238827900; 58192382000; 58510465700; 58538730000; 55808014500; 56637576900 | kimhh@kumoh.ac.kr;hyoo@gachon.ac.kr; | ADVANCED SCIENCE | ADV SCI | 2198-3844 | 10 | 30 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY | 2023 | 14.3 | 6.5 | 1.17 | 2025-06-25 | 6 | 8 | graphene; machine learning attack; physical unclonable function; raman spectroscopy; self-assembled monolayer | FIELD-EFFECT TRANSISTORS; ELECTRONIC-STRUCTURE; CHARGE-TRANSFER; RAMAN; PERFORMANCE; STRAIN; PUF | graphene; machine learning attack; physical unclonable function; raman spectroscopy; self-assembled monolayer | Hamming distance; Machine learning; Network security; Raman spectroscopy; Self assembled monolayers; Active Layer; Attack resistants; Defence systems; Doping state; Machine learning attack; Machine-learning; Mixed layer; Octadecyltrichlorosilane; Physically unclonable functions; Security key; Graphene | English | 2023 | 2023-10 | 10.1002/advs.202302604 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Organic Memristor-Based Flexible Neural Networks with Bio-Realistic Synaptic Plasticity for Complex Combinatorial Optimization | Hardware neural networks with mechanical flexibility are promising next-generation computing systems for smart wearable electronics. Several studies have been conducted on flexible neural networks for practical applications; however, developing systems with complete synaptic plasticity for combinatorial optimization remains challenging. In this study, the metal-ion injection density is explored as a diffusive parameter of the conductive filament in organic memristors. Additionally, a flexible artificial synapse with bio-realistic synaptic plasticity is developed using organic memristors that have systematically engineered metal-ion injections, for the first time. In the proposed artificial synapse, short-term plasticity (STP), long-term plasticity, and homeostatic plasticity are independently achieved and are analogous to their biological counterparts. The time windows of the STP and homeostatic plasticity are controlled by the ion-injection density and electric-signal conditions, respectively. Moreover, stable capabilities for complex combinatorial optimization in the developed synapse arrays are demonstrated under spike-dependent operations. This effective concept for realizing flexible neuromorphic systems for complex combinatorial optimization is an essential building block for achieving a new paradigm of wearable smart electronics associated with artificial intelligent systems. | Kim, Hyeongwook; Kim, Miseong; Lee, Aejin; Park, Hea-Lim; Jang, Jaewon; Bae, Jin-Hyuk; Kang, In Man; Kim, Eun-Sol; Lee, Sin-Hyung | Kyungpook Natl Univ, Sch Elect Engn, 80 Daehak-ro, Daegu 702701, South Korea; Kyungpook Natl Univ, Sch Elect & Elect Engn, 80 Daehak-ro, Daegu 702701, South Korea; Seoul Natl Univ Sci & Technol, Dept Mat Sci & Engn, Seoul 01811, South Korea; Hanyang Univ, Dept Comp Sci, 222 Wangsimni-ro, Seoul 04763, South Korea | Lee, Sin-Hyung/ABD-6425-2022; Lee, Aejin/GLR-5013-2022 | 58249473000; 54983043300; 58250177200; 55735654600; 57194107504; 35326180700; 7203062678; 56296379200; 57226880204 | eunsolkim@hanyang.ac.kr;sinhlee@knu.ac.kr; | ADVANCED SCIENCE | ADV SCI | 2198-3844 | 10 | 19 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY | 2023 | 14.3 | 6.5 | 4.81 | 2025-06-25 | 33 | 33 | artificial synapse; combinatorial optimization; flexible neural network; organic memristor; synaptic plasticity | TERM PLASTICITY; MEMORY; MECHANISMS; SEARCH; ARRAYS; DEVICE | artificial synapse; combinatorial optimization; flexible neural network; organic memristor; synaptic plasticity | Complex networks; Flexible electronics; Intelligent systems; Memristors; Metal ions; Wearable technology; Artificial synapse; Flexible neural network; Injection density; Ion injection; Memristor; Metals ions; Neural-networks; Organic memristor; Organics; Synaptic plasticity; Combinatorial optimization | English | 2023 | 2023-07 | 10.1002/advs.202300659 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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