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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | The Modulatory Effects of Lacticaseibacillus paracasei Strain NSMJ56 on Gut Immunity and Microbiome in Early-Age Broiler Chickens | Simple Summary Feed additives have been used in the livestock industry because of their positive effect on animals, including broiler chickens. Recently, probiotics, which are one of the representative feed additives for antibiotic replacement, have been widely used due to the prohibition of the use of antibiotics in the livestock industry. Various beneficial effects of probiotic Lactobacillus spp. have been reported; however, to our knowledge, there are few studies related to their regulating effects on gut immunity and microbiome in early-age broiler chickens. In the present study, we performed a comparative animal study on gut immunity and gut microbiome in early-age broiler chickens fed either a control diet or Lacticaseibacillus paracasei NSMJ56-supplemented diet. Our results suggest that L. paracasei NSMJ56 has modulatory effects on the gut environment, such as gut immunity and microbiome, in early-age broiler chickens. Gut health has been attracting attention in the livestock industry as several studies suggest that it is a crucial factor for growth performance and general health status in domestic animals, including broiler chickens. Previously, antibiotics were widely used to improve livestock growth, but their use is now prohibited due to serious problems related to antibiotic resistance. Thus, finding new feed additives to replace antibiotics is drawing attention. Probiotics are representative feed additives and many beneficial effects on broiler chickens have been reported. However, many probiotic studies are focused on productivity only, and there are insufficient studies related to the gut environment, especially gut immunity and gut microbiome. In this study, we conducted an animal experiment using Lacticaseibacillus paracasei NSMJ56 to determine whether it has beneficial effects on gut immunity and microbiome. To evaluate the effects of NSMJ56 supplementation, newly hatched Ross 308 broiler chickens were fed an NSMJ56-containing diet for 10 days, and growth performance, antioxidant indicators, gut morphology, gut immunity-related parameters, and gut microbiome were analyzed. Flow cytometry analysis results revealed that NSMJ56 treatment increased CD4+ T cells and decreased CD8+ T cells in small intestine lamina propria and decreased IL1b and IL10 gene expression in small intestine tissue. In the microbiome analysis, NSMJ56 treatment increased the alpha diversity indices and led to three enriched genera: Massilimicrobiota, Anaerotignum, and Coprococcus. This study suggests that NSMJ56 supplementation has regulatory effects on gut immunity and microbiome in early-age broiler chickens. | Joo, Sang Seok; Yoon, June Hyeok; Jung, Ji Young; Joo, Sung Yong; An, Su Hyun; Ban, Byeong Cheol; Kong, Changsu; Kim, Myunghoo | Pusan Natl Univ, Coll Nat Resources & L Sci, Dept Anim Sci, Miryang 50463, South Korea; Kyungpook Natl Univ, Dept Anim Sci & Biotechnol, Sangju 37224, South Korea; Nakdonggang Natl Inst Biol Resources NNIBR, Microbial Res Dept, 137,Donam 2-gil, Sangju 37242, South Korea; Kyungpook Natl Univ, Dept Anim Sci, Sangju 37224, South Korea; Kyungpook Natl Univ, Res Inst Horse Ind, Sangju 37224, South Korea; Pusan Natl Univ, Life & Ind Convergence Res Inst, Mirayng 50463, South Korea | 안, 수현/JFK-5079-2023 | 57215860725; 57995779900; 58915180600; 57995629100; 57216974969; 57995927600; 36027521600; 36611749600 | changsukong@knu.ac.kr;mhkim18@pusan.ac.kr; | ANIMALS | ANIMALS-BASEL | 2076-2615 | 12 | 23 | SCIE | AGRICULTURE, DAIRY & ANIMAL SCIENCE;VETERINARY SCIENCES | 2022 | 3 | 8.7 | 1.22 | 2025-06-25 | 7 | 6 | early-age broiler chickens; feed additive; probiotics; gut immunity; microbiome | GROWTH-PERFORMANCE; BACTERIAL COMMUNITY; INNATE IMMUNITY; SYSTEM; PROBIOTICS | early-age broiler chickens; feed additive; gut immunity; microbiome; probiotics | catalase; food additive; malonaldehyde; phosphate buffered saline; probiotic agent; volatile fatty acid; animal experiment; animal tissue; antioxidant activity; Article; bacterial strain; bacterial strain NSMJ56; broiler; cell isolation; colony forming unit; controlled study; flow cytometry; Gallus gallus; histology; immunity; Lactobacillus paracasei; lamina propria; male; microbiome; nonhuman; RNA extraction | English | 2022 | 2022-12 | 10.3390/ani12233413 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | A durable VO2 transition layer and defect inactivation in BiVO4via spontaneous valence-charge control | The performance of bismuth vanadate (BiVO4) photoanodes is limited by surface defects and photo-corrosion instability. This paper proposes a revolutionary protection layer that overcomes these problems. Considering the role of V5+ ion dissolution in photo-corrosion, we propose a surface photoelectrochemical oxidation approach, artificially altering photo-corrosion to advanced photo-oxidation by strategically adding V5+ and H2O2 to the electrolyte. The surface phase transition thus induced creates an unprecedented vanadium oxide (VO2) photoelectrochemical protection layer that is robust, conductive, and ultrathin, while exhibiting atomic controllability. Charge-kinetic characterization of the BiVO4/VO2 photoanodes revealed faster transport of interfacial charges (86%) and transfer of photogenerated carriers through the VO2 protection layer (95%); this approach affords near-ideal performance and contributes toward high stability and extreme durability. The BiVO4/VO2/CoFeOx photoanodes displayed a high photocurrent density of 6.2 mA cm(-2) and an onset potential of 0.25 V-RHE, with an applied bias photon-to-current efficiency of 2.4% at 0.62 V-RHE. | Kim, Dong Su; Lee, Kun Woong; Choi, Ji Hoon; Lee, Hak Hyeon; Suh, Hee Won; Lee, Ho Seong; Cho, Hyung Koun | Sungkyunkwan Univ, Sch Adv Mat Sci & Engn, 2066 Seobu Ro, Suwon 16419, Gyeonggi Do, South Korea; Sungkyunkwan Univ SKKU, Res Ctr Adv Mat Technol, 2066 Seobu Ro, Suwon, Gyeonggi Do, South Korea; Kyungpook Natl Univ, Sch Mat Sci & Engn, 80 Daehak Ro, Daegu 41566, South Korea | Cho, Hyung Koun/P-2007-2017; 김, 동수/IAN-1770-2023; Cho, Hyung/P-2007-2017 | 57209168253; 57255172600; 57218377818; 57923457900; 57222623083; 55706810400; 35236454300 | chohk@skku.edu; | JOURNAL OF MATERIALS CHEMISTRY A | J MATER CHEM A | 2050-7488 | 2050-7496 | 10 | 40 | SCIE | CHEMISTRY, PHYSICAL;ENERGY & FUELS;MATERIALS SCIENCE, MULTIDISCIPLINARY | 2022 | 11.9 | 8.8 | 0.66 | 2025-06-25 | 11 | 11 | WATER OXIDATION PERFORMANCE; BIVO4 PHOTOANODES; PHOTOELECTROCHEMICAL PERFORMANCE; HYDROGEN-PRODUCTION; SURFACE-STATES; EFFICIENCY; STABILITY; HEMATITE; FILMS | Bismuth compounds; Corrosion; Electrochemistry; Surface defects; Vanadium dioxide; Bismuth vanadates; Charge control; Performance; Photo oxidation; Photo-anodes; Photo-electrochemical oxidations; Photoelectrochemicals; Protection layers; Surface phase transitions; Transition layers; Electrolytes | English | 2022 | 2022-10-18 | 10.1039/d2ta05260a | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Anti-Obesity Effects of Ecklonia cava Extract in High-Fat Diet-Induced Obese Rats | Obesity is becoming a global epidemic as a result of high-calorie food intake and unhealthy lifestyles. Different marine plants, especially brown algae (Ecklonia cava), are traditionally used to treat different health-related issues. The study was carried out to investigate the anti-obesity properties of E. cava 70% ethanol extract. To evaluate the anti-obesity effect of E. cava, both in vitro and in vivo tests were performed. E. cava suppresses pre-adipocyte 3T3-L1 differentiation in a dose-dependent manner. In HFD-induced obese rats' models, administration of E. cava 125, 250, and 500 mg/kg significantly decreases total body weight and organs, especially liver weight, in all treatment groups. Adipose tissue weight, including subcutaneous, epididymal, peritoneal, and mesenteric adipose tissue, was markedly reduced in E. cava-treated HFD rats in dose-dependent manners. In addition, liver-related biomarkers AST, ALP, ALT, and GGT were evaluated; the lower level of liver-related biomarkers indicates no liver injury or fatty liver issue in E. cava HFD treatment groups. In addition, E. cava treatment has significant effects on the expression of adipogenic and lipogenic (PPAR-gamma, FAS, LPL, and SREBP-1c) genes. Altogether, these results show the anti-obesity effect of E. cava. We concluded that E. cava could be a potential candidate for the prevention of obesity-induced by a high-fat diet. | Abbas, Muhammad Aleem; Boby, Naila; Lee, Eon-Bee; Hong, Joo-Heon; Park, Seung-Chun | Kyungpook Natl Univ, Coll Vet Med, Cardiovasc Inst, Lab Vet Pharmacokinet & Pharmacodynam, Daegu 41566, Gyeongsangbuk D, South Korea; Anim & Plant Quarantine Agcy, Bacterial Dis Div, 177 Hyeksin 8-ro, Gimcheon Si 39660, Gyeongsangbuk D, South Korea; Daegu Catholic Univ, Dept Food Sci & Technol, Hayang Ro 13-13, Gyongsan 38430, Gyeongsangbuk D, South Korea | Lee, Jung Bok/HHZ-3200-2022; Boby, Naila/GRE-8096-2022; Park, Seung-Chun/AAV-3388-2021; Abbas, Muhammad Aleem/GLT-8362-2022 | 57216531374; 57197787296; 57216526135; 35264362800; 7501832396 | syedaleemabbas77@knu.ac.kr;nailaboby@korea.kr;eonbee@gmail.com;jhhong@cu.ac.kr;parksch@knu.ac.kr; | ANTIOXIDANTS | ANTIOXIDANTS-BASEL | 2076-3921 | 11 | 2 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY | 2022 | 7 | 8.8 | 2.41 | 2025-06-25 | 25 | 25 | anti-obesity; Ecklonia cava; brown alga; high-fat diet; leptin and ghrelin; liver biomarkers; phlorotannin; obesity; ROC; antioxidant | ENZYME-ACTIVITY; IMPACT; ASSOCIATION; MECHANISMS; ADIPOSITY; TOXICITY; GHRELIN; DISEASE; GLUCOSE | 3T3-L1; Anti-obesity; Antioxidant; Brown alga; Ecklonia cava; High-fat diet; Leptin and ghrelin; Liver biomarkers; Obesity; Phlorotannin; ROC | English | 2022 | 2022-02 | 10.3390/antiox11020310 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Antioxidant and anti-inflammatory roles of tea polyphenols in inflammatory bowel diseases | Polyphenols, including phenolic acids, flavonoids, and procyanidins, are abundant in food and beverage derived from plants. Tea (Camellia sinensis) is particularly rich in polyphenols (e.g., catechins, theaflavins, thearubigins, gallic acid, and flavonols), which are thought to contribute to the health benefits of tea. High intake of tea polyphenols has been described to prevent and/or attenuate a variety of chronic pathological conditions like cardiovascular diseases, neurodegenerative diseases, diabetes, and cancer. This review focuses on established antioxidant and anti-inflammatory properties of tea polyphenols and underlying mechanisms of their involvement in inflammatory bowel diseases (IBD). Tea polyphenols act as efficient antioxidants by inducing an endogenous antioxidant defense system and maintaining intracellular redox homeostasis. Tea polyphenols also regulate signaling pathways such as nuclear factor-KB, activator protein 1, signal transducer and activator of transcriptions, and nuclear factor E2-related factor 2, which are associated with IBD development. Accumulating pieces of evidence have indicated that tea polyphenols enhance epithelial barrier function and improve gut microbial dysbiosis, contributing to the management of inflammatory colitis. Therefore, this study suggests that supplementation of tea polyphenols could prevent inflammatory conditions and improve the outcome of patients with IBD. (C) 2022 Beijing Academy of Food Sciences. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. | Truong, Van-Long; Jeong, Woo-Sik | Kyungpook Natl Univ, Coll Agr & Life Sci, Sch Food Sci & Biotechnol, Food & Bioind Res Inst, Daegu 41566, South Korea | Jeong, Woo-Sik/AAN-6885-2020 | 55925363400; 10440750200 | wsjeong@knu.ac.kr; | FOOD SCIENCE AND HUMAN WELLNESS | FOOD SCI HUM WELL | 2213-4530 | 11 | 3 | SCIE | FOOD SCIENCE & TECHNOLOGY;NUTRITION & DIETETICS | 2022 | 7 | 8.8 | 4.06 | 2025-06-25 | 111 | 124 | Antioxidant; Anti-inflammation; Epithelial barrier function; Inflammatory bowel diseases; Gut microbiota; Tea polyphenols | NF-KAPPA-B; GREEN TEA; DIETARY POLYPHENOLS; INTESTINAL BARRIER; CAMELLIA-SINENSIS; OXIDATIVE STRESS; GUT MICROBIOTA; IMMUNE-SYSTEM; CACO-2 CELLS; BLACK TEA | Anti-inflammation; Antioxidant; Epithelial barrier function; Gut microbiota; Inflammatory bowel diseases; Tea polyphenols | English | 2022 | 2022-05 | 10.1016/j.fshw.2021.12.008 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Antioxidant Effects of Korean Propolis in HaCaT Keratinocytes Exposed to Particulate Matter 10 | Air pollution causes oxidative stress that leads to inflammatory diseases and premature aging of the skin. The purpose of this study was to examine the antioxidant effect of Korean propolis on oxidative stress in human epidermal HaCaT keratinocytes exposed to particulate matter with a diameter of less than 10 mu m (PM10). The total ethanol extract of propolis was solvent-fractionated with water and methylene chloride to divide into a hydrophilic fraction and a lipophilic fraction. The lipophilic fraction of propolis was slightly more cytotoxic, and the hydrophilic fraction was much less cytotoxic than the total extract. The hydrophilic fraction did not affect the viability of cells exposed to PM10, but the total propolis extract and the lipophilic fraction aggravated the toxicity of PM10. The total extract and hydrophilic fraction inhibited PM10-induced ROS production and lipid peroxidation in a concentration-dependent manner, whereas the lipophilic fraction did not show such effects. High-performance liquid chromatography with photodiode array detection (HPLC-DAD) analysis showed that the hydrophilic fraction contained phenylpropanoids, such as caffeic acid, p-coumaric acid, and ferulic acid, whereas the lipophilic faction contained caffeic acid phenethyl ester (CAPE). The former three compounds inhibited PM10-induced ROS production, lipid peroxidation, and/or glutathione oxidation, and ferulic acid was the most effective among them, but CAPE exhibited cytotoxicity and aggravated the toxicity of PM10. This study suggests that Korean propolis, when properly purified, has the potential to be used as a cosmetic material that helps to alleviate the skin toxicity of air pollutants. | Bae, In Ah; Ha, Jae Won; Choi, Joon Yong; Boo, Yong Chool | Kyungpook Natl Univ, Grad Sch, Dept Biomed Sci, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, BK21 Plus KNU Biomed Convergence Program, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Mol Med, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, 680 Gukchaebosang Ro, Daegu 41944, South Korea | 57575559300; 57210154932; 57576409100; 6602899130 | sksnadlv@naver.com;jaewon1226@knu.ac.kr;halo134679@naver.com;ycboo@knu.ac.kr; | ANTIOXIDANTS | ANTIOXIDANTS-BASEL | 2076-3921 | 11 | 4 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY | 2022 | 7 | 8.8 | 1.45 | 2025-06-25 | 11 | 16 | Korean propolis; particulate matter; oxidative stress; keratinocytes; ferulic acid; caffeic acid; p-coumaric acid | ACID PHENETHYL ESTER; CAFFEIC ACID; COUMARIC ACID; AIR-QUALITY; CONSTITUENTS; DERIVATIVES; POLLUTANTS; PARTICLES; APOPTOSIS; EXTRACTS | caffeic acid; ferulic acid; keratinocytes; Korean propolis; oxidative stress; p-coumaric acid; particulate matter | English | 2022 | 2022-04 | 10.3390/antiox11040781 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Review | Ascorbic Acid (Vitamin C) as a Cosmeceutical to Increase Dermal Collagen for Skin Antiaging Purposes: Emerging Combination Therapies | Ascorbic acid (AA) is an essential nutrient and has great potential as a cosmeceutical that protects the health and beauty of the skin. AA is expected to attenuate photoaging and the natural aging of the skin by reducing oxidative stress caused by external and internal factors and by promoting collagen gene expression and maturation. In this review, the biochemical basis of AA associated with collagen metabolism and clinical evidence of AA in increasing dermal collagen and inhibiting skin aging were discussed. In addition, we reviewed emerging strategies that have been developed to overcome the shortcomings of AA as a cosmeceutical and achieve maximum efficacy. Because extracellular matrix proteins, such as collagen, have unique amino acid compositions, their production in cells is influenced by the availability of specific amino acids. For example, glycine residues occupy 1/3 of amino acid residues in collagen protein, and the supply of glycine can be a limiting factor for collagen synthesis. Experiments showed that glycinamide was the most effective among the various amino acids and amidated amino acids in stimulating collagen production in human dermal fibroblasts. Thus, it is possible to synergistically improve collagen synthesis by combining AA analogs and amino acid analogs that act at different stages of the collagen production process. This combination therapy would be useful for skin antiaging that requires enhanced collagen production. | Boo, Yong Chool | Kyungpook Natl Univ, Sch Med, Dept Mol Med, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Grad Sch, Dept Biomed Sci, BK21 Plus KNU Biomed Convergence Program, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, 680 Gukchaebosang Ro, Daegu 41944, South Korea | 6602899130 | ycboo@knu.ac.kr; | ANTIOXIDANTS | ANTIOXIDANTS-BASEL | 2076-3921 | 11 | 9 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY | 2022 | 7 | 8.8 | 3.9 | 2025-06-25 | 88 | 102 | ascorbic acid; vitamin C; collagen; skin aging; antiaging; amino acid; glycinamide; glycine; cosmetic; cosmeceutical | DOUBLE-BLIND; MESSENGER-RNA; ALPHA-TOCOPHEROL; III COLLAGEN; I COLLAGEN; BIOSYNTHESIS; GENE; EXPRESSION; STABILITY; TRANSCRIPTION | amino acid; antiaging; ascorbic acid; collagen; cosmeceutical; cosmetic; glycinamide; glycine; skin aging; vitamin C | English | 2022 | 2022-09 | 10.3390/antiox11091663 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Drought and UV Radiation Stress Tolerance in Rice Is Improved by Overaccumulation of Non-Enzymatic Antioxidant Flavonoids | Drought and ultraviolet radiation (UV radiation) are the coexisting environmental factors that negatively affect plant growth and development via oxidative damage. Flavonoids are reactive, scavenging oxygen species (ROS) and UV radiation-absorbing compounds generated under stress conditions. We investigated the biosynthesis of kaempferol and quercetin in wild and flavanone 3-hydroxylase (F3H) overexpresser rice plants when drought and UV radiation stress were imposed individually and together. Phenotypic variation indicated that both kinds of stress highly reduced rice plant growth parameters in wild plants as compared to transgenic plants. When combined, the stressors adversely affected rice plant growth parameters more than when they were imposed individually. Overaccumulation of kaempferol and quercetin in transgenic plants demonstrated that both flavonoids were crucial for enhanced tolerance to such stresses. Oxidative activity assays showed that kaempferol and quercetin overaccumulation with strong non-enzymatic antioxidant activity mitigated the accumulation of ROS under drought and UV radiation stress. Lower contents of salicylic acid (SA) in transgenic plants indicated that flavonoid accumulation reduced stress, which led to the accumulation of low levels of SA. Transcriptional regulation of the dehydrin (DHN) and ultraviolet-B resistance 8 (UVR8) genes showed significant increases in transgenic plants compared to wild plants under stress. Taken together, these results confirm the usefulness of kaempferol and quercetin in enhancing tolerance to both drought and UV radiation stress. | Jan, Rahmatullah; Khan, Muhammad-Aaqil; Asaf, Sajjad; Lubna; Waqas, Muhammad; Park, Jae-Ryoung; Asif, Saleem; Kim, Nan; Lee, In-Jung; Kim, Kyung-Min | Kyungpook Natl Univ, Coll Agr & Life Sci, Dept Appl Biosci, Div Plant Biosci, 80 Dahak Ro, Daegu 41566, South Korea; Kyungpook Natl Univ, Costal Agr Res Inst, 80 Dahak Ro, Daegu 41566, South Korea; Univ Nizwa, Nat & Med Sci Res Ctr, Nizwa 616, Oman; Abdul Wali Khan Univ, Dept Bot, Garden Campus, Mardan 23200, Pakistan; Govt Khyber Pakhtunkhwa, Dept Agr Extens, Mardan 23200, Pakistan; Rural Dev Adm, Crop Breeding Div, Natl Inst Crop Sci, Wonju 55365, South Korea | Jan, Rahmatullah/AIC-3439-2022; Khan, Muhammad/ABB-9797-2021; Kim, Kyung-Min Kim/C-7007-2014; Waqas, Muhammad/IYS-9931-2023; Asaf, Sajjad/ABA-3647-2021; Lee, In-Jung/GLS-0432-2022 | 57201981969; 57188585606; 56595059900; 57200621537; 59139606000; 57211205505; 57396413700; 57395985700; 16425830900; 34868260300 | rahmat2021@knu.ac.kr;aqil_bacha@knu.ac.kr;sajjadasaf@unizwa.edu.om;lubnabilal68@gmail.com;agranomist89@yahoo.com;icd0192@korea.kr;saleemasif10@knu.ac.kr;jennynari@knu.ac.kr;ijlee@knu.ac.kr;kkm@knu.ac.kr; | ANTIOXIDANTS | ANTIOXIDANTS-BASEL | 2076-3921 | 11 | 5 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY | 2022 | 7 | 8.8 | 6.46 | 2025-06-25 | 64 | 72 | drought and UV radiation stress; flavonoids content; antioxidant content; salicylic acid; genes expression | ULTRAVIOLET-B RADIATION; SIGNALING COMPONENT UVR8; GENOME-WIDE ANALYSIS; FLAVANONE 3-HYDROXYLASE; GENE-EXPRESSION; SALICYLIC-ACID; DEHYDRIN GENE; ARABIDOPSIS; PLANT; BIOSYNTHESIS | antioxidant content; drought and UV radiation stress; flavonoids content; genes expression; salicylic acid | English | 2022 | 2022-05 | 10.3390/antiox11050917 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Endophytic Fungal Consortia Enhance Basal Drought-Tolerance in Moringa oleifera by Upregulating the Antioxidant Enzyme (APX) through Heat Shock Factors | Global climate change has imposed harsh environmental conditions such as drought. Naturally, the most compatible fungal consortia operate synergistically to enhance plant growth and ecophysiological responses against abiotic strains. Yet, little is known about the interactions between phytohormone-producing endophytic fungal symbionts and plant growth under drought stress. The existing research was rationalized to recognize the role of newly isolated drought-resistant, antioxidant-rich endophytic fungal consortia hosting a xerophytic plant, Carthamus oxycantha L., inoculated to Moringa oleifera L. grown under drought stress of 8% PEG (polyethylene glycol-8000). Under drought stress, the combined inoculation of endophytic strain Microdochium majus (WA), Meyerozyma guilliermondi (TG), and Aspergillus aculeatus (TL3) exhibited a significant improvement in growth attributes such as shoot fresh weight (1.71-fold), shoot length (0.86-fold), root length (0.65-fold), dry weight (2.18-fold), total chlorophyll (0.46-fold), and carotenoids (0.87-fold) in comparison to control (8% PEG). Primary and secondary metabolites were also increased in M. oleifera inoculated with endophytic consortia, under drought stress, such as proteins (1.3-fold), sugars (0.58-fold), lipids (0.41-fold), phenols (0.36-fold), flavonoids (0.52-fold), proline (0.6-fold), indole acetic acid (IAA) (4.5-fold), gibberellic acid (GA) (0.7-fold), salicylic acid (SA) (0.8-fold), ascorbic acid (ASA) (1.85-fold), while abscisic acid (ABA) level was decreased (-0.61-fold) in comparison to the control (8% PEG). Under drought stress, combined inoculation (WA, TG, TL3) also promoted the antioxidant activities of enzymes such as ascorbate peroxidase (APX) (3.5-fold), catalase (CAT) activity (1.7-fold), and increased the total antioxidant capacity (TAC) (0.78-fold) with reduced reactive oxygen species (ROS) such as H2O2 production (-0.4-fold), compared to control (8% PEG), and stomatal aperture was larger (3.5-fold) with a lesser decrease (-0.02-fold) in water potential. Moreover, combined inoculation (WA, TG, TL3) up regulated the expression of MolHSF3, MolHSF19, and MolAPX genes in M. oleifera under drought stress, compared to the control (8% PEG), is suggestive of an important regulatory role for drought stress tolerance governed by fungal endophytes. The current research supports the exploitation of the compatible endophytic fungi for establishing the tripartite mutualistic symbiosis in M. oleifera to alleviate the adverse effects of drought stress through strong antioxidant activities. | Javed, Javeria; Rauf, Mamoona; Arif, Muhammad; Hamayun, Muhammad; Gul, Humaira; Ud-Din, Aziz; Ud-Din, Jalal; Sohail, Mohammad; Rahman, Muhammad Mizanur; Lee, In-Jung | Abdul Wali Khan Univ Mardan, Dept Bot, Mardan 23200, Pakistan; Abdul Wali Khan Univ Mardan, Dept Biotechnol, Mardan 23200, Pakistan; Hazara Univ Mansehra, Dept Biotechnol & Genet Engn, Mansehra 21120, Pakistan; Islamic Univ, Dept Biotechnol & Genet Engn, Kushtia 7003, Bangladesh; Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea | UDDIN, MD JALAL/JLL-0285-2023; Lee, In-Jung/GLS-0432-2022; rauf, mamoona/AAC-3246-2019; Rauf, Mamoona/AAC-3246-2019; Hamayun, Muhammad/B-1694-2010; Arif, Muhammad/GNM-5831-2022; Rahman, Mohammad/KHY-3819-2024 | 57481473900; 55609311400; 57202654530; 59297330100; 7003592765; 57188860666; 59948677500; 57607715500; 55568450200; 16425830900 | mamoona@awkum.edu.pk;arif@awkum.edu.pk; | ANTIOXIDANTS | ANTIOXIDANTS-BASEL | 2076-3921 | 11 | 9 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY | 2022 | 7 | 8.8 | 3.9 | 2025-06-25 | 35 | 43 | plant-microbe interaction; Moringa oleifera; drought stress; phytohormones; antioxidants; ascorbate peroxidase; heat shock factors; hydrogen peroxide | PLANT PRODUCTIVITY; CLIMATE-CHANGE; RESPONSES; WHEAT; ATTRIBUTES; MODULATION; MAIZE | antioxidants; ascorbate peroxidase; drought stress; heat shock factors; hydrogen peroxide; Moringa oleifera; phytohormones; plant-microbe interaction | English | 2022 | 2022-09 | 10.3390/antiox11091669 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Article | Energy harvesting of fully-flexible magnetoelectric composites using a piezoelectric P(VDF-TrFE) and magnetostrictive CoFe2O4 nanofiber | In response to the increasing demand for wearable devices, the development of flexible energy harvesters as self-powering systems to replace batteries is accelerating. Flexible magnetoelectric (ME) composites, which can convert practical electrical energy from a magnetic field source, have attracted considerable attention for application in wearable magnetic devices. In this study, a 2-2 type structure based on a flexible magnetostrictive film with cobalt ferrite (CoFe2O4, CFO) nanofibers was adopted to obtain appropriate flexibility and magnetoelectric properties. The flexible ME composite was completely fabricated by coating piezoelectric poly(vinylidene fluoride-trifluoroethylene) (P(VDF-TrFE)) onto a magnetostrictive film composed of CFO nanofibers and a polyimide matrix. Moreover, we conducted a multiphysics simulation and theoretically proved that a higher strain could be transferred to the piezoelectric layer at higher CFO concentrations, thus resulting in the generation of high magnetoelectric signals from the ME composite. The flexible, robust, and mechanically-stable ME composite reached an output voltage of 0.52 V and a current signal of 25 nA under an external AC magnetic field at 1 Hz. This study led to the development of a fully-flexible design of a bilayer ME composite prepared using a simple fabrication process providing a future avenue for wearable magnetoelectric energy harvesting. © 2023 The Royal Society of Chemistry. | Nam, Chaeyoung; Na, Yujin; Park, Sung Cheol; Kim, Hyunseung; Jeong, Chang Kyu; Hwang, Geon-Tae; Park, Kwi-Il | School of Materials Science and Engineering, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu, 41566, South Korea; School of Materials Science and Engineering, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu, 41566, South Korea; School of Materials Science and Engineering, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu, 41566, South Korea; Division of Advanced Materials Engineering, Jeonbuk National University, Jeonbuk, Jeonju, 54896, South Korea; Division of Advanced Materials Engineering, Jeonbuk National University, Jeonbuk, Jeonju, 54896, South Korea; Department of Materials Science and Engineering, Pukyong National University, Busan, 48513, South Korea; School of Materials Science and Engineering, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu, 41566, South Korea | 57215533862; 57566141800; 57191670545; 57216301848; 55961876600; 36704574900; 35280874200 | gthwang@pknu.ac.kr;kipark@knu.ac.kr; | Journal of Materials Chemistry A | J MATER CHEM A | 2050-7488 | 2050-7496 | 11 | 2 | SCIE | CHEMISTRY, PHYSICAL;ENERGY & FUELS;MATERIALS SCIENCE, MULTIDISCIPLINARY | 2022 | 11.9 | 8.8 | 1.79 | 2025-06-25 | 30 | Energy harvesting; Fluorine compounds; Iron compounds; Magnetic fields; Magnetostrictive devices; Nanocomposite films; Piezoelectricity; Wearable technology; Electrical energy; Energy Harvester; Magnetoelectric composites; Magnetoelectrics; Magnetostrictive films; Piezoelectric; Poly(vinylidene fluoride-trifluoroethylene); Powering systems; Self-powering; Wearable devices; Nanofibers | English | Final | 2022 | 10.1039/d2ta06171f | 바로가기 | 바로가기 | 바로가기 | ||||||||
| ○ | Article | Enhanced Piezoelectric Performance of Composite Fibers Based on Lead-Free BCTZ Ceramics and P(VDF-TrFE) Piezopolymer for Self-Powered Wearable Sensors | Flexible piezoelectric energy harvesters (f-PEHs) have recently become popular alternative power sources for smart and wearable devices. For applications in self-powered wearable devices and biomedical applications, f-PEHs should exhibit high flexibility, nontoxicity, and excellent piezoelectricity. In this study, we developed high-efficiency ultra-f-PEHs based on electrospun piezoelectric composite fiber (PCF) membranes composed of lead-free (Ba0.85Ca0.15)(Ti0.90Zr0.10)O3(BCTZ) nanoparticles (NPs) and poly(vinylidene fluoride-co-trifluoroethylene) (P(VDF-TrFE)) fibers. In particular, post-treatments, including post-crystallization and an extra-poling process, were exploited to further enhance the piezoelectricity of the PCFs. The PCF membrane reached an output voltage of 36.5 V, a current signal of 1.09 μA, and an effective output power of 13.2 μW, which are higher compared to the previously reported PCF-based energy harvesters. Furthermore, an ultra-f-PEH consisting of aluminum electrodes, PCF membranes, and polydimethylsiloxane elastomers was proposed and successfully monitored tiny bio-signals, such as carotid pulses, vocalization, and articular bending motions. This study provides suggestions for applications in wearable and biomedical self-powered electronics using piezoelectric energy-harvesting systems. © 2022 American Chemical Society. All rights reserved. | Park, Sung Cheol; Nam, Chaeyoung; Baek, Changyeon; Lee, Min-Ku; Lee, Gyoung-Ja; Park, Kwi-Il | School of Materials Science and Engineering, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu, 41566, South Korea; School of Materials Science and Engineering, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu, 41566, South Korea; Smart Sensing & Diagnosis Research Division, Korea Atomic Energy Research Institute, 111 Daedeok-daero, 989 beon-gil, Yuseong-gu, Daejeon, 34057, South Korea; Smart Sensing & Diagnosis Research Division, Korea Atomic Energy Research Institute, 111 Daedeok-daero, 989 beon-gil, Yuseong-gu, Daejeon, 34057, South Korea; Smart Sensing & Diagnosis Research Division, Korea Atomic Energy Research Institute, 111 Daedeok-daero, 989 beon-gil, Yuseong-gu, Daejeon, 34057, South Korea; School of Materials Science and Engineering, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu, 41566, South Korea | 57191670545; 57215533862; 57095549400; 59302175900; 8588965200; 35280874200 | leegj@kaeri.re.kr;kipark@knu.ac.kr; | ACS Sustainable Chemistry and Engineering | ACS SUSTAIN CHEM ENG | 2168-0485 | 2168-0485 | 10 | 43 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;ENGINEERING, CHEMICAL;GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY | 2022 | 8.4 | 8.8 | 1.23 | 2025-06-25 | 21 | BCTZ; composite fiber; lead-free; P(VDF-TrFE); piezoelectric; wearable sensor | Composite membranes; Crystallography; Energy harvesting; Fibers; Fluorine compounds; Medical applications; Piezoelectric devices; Silicones; Wearable sensors; (NP) and poly(vinylidene fluoride-co-trifluoroethylene); BCTZ; Composite fibres; Lead-Free; Piezoelectric; Piezoelectric composite; Piezoelectric energy harvesters; Poly(vinylidene fluoride); Self-powered; Trifluoroethylene; Piezoelectricity | English | Final | 2022 | 10.1021/acssuschemeng.2c05026 | 바로가기 | 바로가기 | 바로가기 | |||||||
| ○ | Erratum | Erratum: An organometal halide perovskite photocathode integrated with a MoS2 catalyst for efficient and stable photoelectrochemical water splitting (Journal of Materials Chemistry A (2021) 9 (22291-22300) DOI: 10.1039/D1TA05377A) | The authors regret that one funding project number was incorrectly shown in the Acknowledgements section of the original manuscript. The full and correct list of funders are as shown below. This study was supported by the National Research Foundation (NRF) of Korea funded by the MSIT (grant no. 2020R1A2C1005590), the program of Future Hydrogen Original Technology Development of the NRF of Korea funded by the MSIT (grant no. 2021M3I3A1084747), the Creative Materials Discovery Program of the NRF of Korea funded by the MSIT (grant no. 2017M3D1A1040834), the Global Research Laboratory (GRL) Program of the NRF of Korea funded by the Ministry of Science, ICT & Future Planning (grant no. NRF2017K1A1A2013153), and the GIST Research Institute (GRI), RISE, grant funded by the GIST in 2021. The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers. © 2023 The Royal Society of Chemistry. | Choi, Hojoong; Seo, Sehun; Kim, Ju-Hyeon; Lee, Jong-Hoon; Kim, Seungkyu; Piao, Guangxia; Park, Hyunwoong; Lee, Kwanghee; Lee, Sanghan | School of Materials Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, 61005, South Korea; School of Materials Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, 61005, South Korea; School of Materials Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, 61005, South Korea, Heeger Center for Advanced Materials, Gwangju Institute of Science and Technology, Gwangju, 61005, South Korea; School of Materials Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, 61005, South Korea, Department of Energy Resources, Huree University of Information and Communication Technology, Ulaanbaatar, 16061-0036, Mongolia; School of Materials Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, 61005, South Korea; School of Energy Engineering, Kyungpook National University, Daegu, 41566, South Korea; School of Energy Engineering, Kyungpook National University, Daegu, 41566, South Korea; School of Materials Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, 61005, South Korea, Heeger Center for Advanced Materials, Gwangju Institute of Science and Technology, Gwangju, 61005, South Korea, Research Institute for Solar and Sustainable Energies, Gwangju Institute of Science and Technology, Gwangju, 61005, South Korea; School of Materials Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, 61005, South Korea | 57212019941; 57192688623; 58925648400; 57203144580; 57201488172; 57193277010; 7601565583; 55737466200; 55716521500 | klee@gist.ac.kr;sanghan@gist.ac.kr; | Journal of Materials Chemistry A | J MATER CHEM A | 2050-7488 | 2050-7496 | 11 | 2 | SCIE | CHEMISTRY, PHYSICAL;ENERGY & FUELS;MATERIALS SCIENCE, MULTIDISCIPLINARY | 2022 | 11.9 | 8.8 | 1.44 | 2025-06-25 | 1 | English | Final | 2022 | 10.1039/d2ta90273g | 바로가기 | 바로가기 | 바로가기 | |||||||||
| ○ | ○ | Article | Flavonoid-Conjugated Gadolinium Complexes as Anti-Inflammatory Theranostic Agents | In this study, we designed, synthesized, and evaluated gadolinium compounds conjugated with flavonoids as potential theranostic agents for the treatment of inflammation. These novel theranostic agents combine a molecular imaging agent and one of three flavonoids (galangin, chrysin, and 7-hydroxyflavone) as anti-inflammatory drugs as a single integrated platform. Using these agents, MR imaging showed contrast enhancement (>10 in CNR) at inflamed sites in an animal inflammation model, and subsequent MR imaging used to monitor the therapeutic efficacy of these integrated agents revealed changes in inflamed regions. The anti-inflammatory effects of these agents were demonstrated both in vitro and in vivo. Furthermore, the antioxidant efficacy of the agents was evaluated by measuring their reactive oxygen species scavenging properties. For example, Gd-galangin at 30 mu M showed a three-fold higher ROS scavenging of DPPH. Taken together, our findings provide convincing evidence to indicate that flavonoid-conjugated gadolinium compounds can be used as potentially efficient theranostic agents for the treatment of inflammation. | Yang, Byeong Woo; Yang, Sohyeon; Kim, Soyeon; Baek, Ah Rum; Sung, Bokyung; Kim, Yeoun-Hee; Lee, Jung Tae; Lee, Sang Yun; Kim, Hee-Kyung; Choi, Garam; Park, Ji-Ae; Nam, Sung-Wook; Lee, Gang-Ho; Chang, Yongmin | Kyungpook Natl Univ, Dept Med & Biol Engn, 80 Daehak-Ro, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Med, Dept Med Sci, 680 Gukchaebosang-Ro, Daegu 41944, South Korea; Korea Inst Radiol & Med Sci KIRAMS, Div Appl RI, 75 Nowon-Ro, Seoul 01812, South Korea; Kyungpook Natl Univ, Inst Biomed Engn Res, 680 Gukchaebosang-Ro, Daegu 41944, South Korea; Etnova Therapeut Corp, R&D Ctr, 124 Sagimakgol-Ro, Seongnam 13207, South Korea; Daegu Gyeongbuk Med Innovat Fdn, Preclin Res Ctr, 88 Dongnae-Ro, Daegu 41061, South Korea; Kyungpook Natl Univ, Sch Med, Dept Mol Med, 680 Gukchaebosang-Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Dept Chem, 80 Daehak-Ro, Daegu 41566, South Korea; Kyungpook Natl Univ Hosp, Dept Radiol, 130 Dongdeok-Ro, Daegu 41944, South Korea | Yang, Byeong Woo/HII-8624-2022; Nam, Sung-Wook/V-5519-2019 | 57195807615; 58034142900; 57203773250; 57194601711; 58929528400; 57576538700; 58033635500; 58034650700; 56014729400; 56013903700; 16319690600; 16167127700; 7404851841; 7501840633 | ychang@knu.ac.kr; | ANTIOXIDANTS | ANTIOXIDANTS-BASEL | 2076-3921 | 11 | 12 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY | 2022 | 7 | 8.8 | 0.29 | 2025-06-25 | 2 | 3 | phytochemical; flavonoid; inflammation; gadolinium complex; theranostics | CONTRAST AGENT; ANTIOXIDANT; TRANSMETALATION; INFLAMMATION; INHIBITORS; DPPH | flavonoid; gadolinium complex; inflammation; phytochemical; theranostics | English | 2022 | 2022-12 | 10.3390/antiox11122470 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Fuzhuan Brick Tea Boosts Melanogenesis and Prevents Hair Graying through Reduction of Oxidative Stress via NRF2-HO-1 Signaling | The anti-graying effect of the hexane fraction of Fuzhuan brick tea is investigated in Melan-A cells and C57BL/6 mice. As a result, it is found that reactive oxygen species-induced damage is associated with the reduction of melanogenesis in hair bulb melanocytes when reactive oxygen species generation in Melan-A cells occurred. The results revealed that the hexane fraction of Fuzhuan brick tea could remarkably reduce reactive oxygen species generation in Melan-A cells; meanwhile, it could increase the cellular tyrosinase and melanin content, as well as up-regulate the expression of tyrosinase, tyrosinase related protein-1, tyrosinase related protein-2, and microphthalmia-associated transcription factor, and activate the MAP-kinase pathway through activating the phosphorylation of p38 c-Jun N terminal kinase/extracellular signal-regulated kinase. Furthermore, high-pressure liquid chromatography analysis reveals that the tea's major ingredients in hexane fraction include gallic acid, theaflavin, theobromine, caffeine, epicatechin, and quercetin. Together, the current results suggest that Fuzhuan brick tea proves to protect from the damage of hydroquinone, which induces hair pigment loss. | Zhao, Peijun; Park, Na Hyun; Alam, Md Badrul; Lee, Sang-Han | Kyungpook Natl Univ, Grad Sch, Dept Food Sci & Biotechnol, Daegu 41566, South Korea; Henan Agr Univ, Dept Food Sci & Technol, Zhengzhou 450046, Peoples R China; Kyungpook Natl Univ, Food & Bioind Res Inst, Daegu 41566, Peoples R China | Lee, Seung Eun/ABG-1607-2021; ALAM, MD BADRUL/AFL-7668-2022; Alam, Md Badrul/AFL-7668-2022 | 57191912964; 57539539700; 56706777100; 57221453703 | zhaopeijun@henau.edu.cn;winner377@knu.ac.kr;mbalam@knu.ac.kr;sang@knu.ac.kr; | ANTIOXIDANTS | ANTIOXIDANTS-BASEL | 2076-3921 | 11 | 3 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY | 2022 | 7 | 8.8 | 0.86 | 2025-06-25 | 10 | 10 | Fuzhuan brick tea; melanogenesis; hair graying; oxidative stress; NRF2; HO-1 | MOUSE MODEL; ACTIVATION; TYROSINASE; MELANOCYTES; VITILIGO; MUTATION | Fuzhuan brick tea; Hair graying; HO-1; Melanogenesis; NRF2; Oxidative stress | English | 2022 | 2022-03 | 10.3390/antiox11030599 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Human likeness and attachment effect on the perceived interactivity of AI speakers | Artificial intelligence (AI) platforms with interactive assistants allow consumers to avail information and help direct their choices, thus changing the ways in which companies interact with their customers. This study aims to explore the concept of human likeness, attachment, and perceived interactivity in the context of AI speakers and examine the effects of human likeness and attachment on their perceived interactivity with AI speakers. A survey was used to investigate whether consumers' perception of human likeness, attachment and their perceived interactivity with AI speakers eventually influence their purchase intention, and how attachment and the perceived interactivity mediate the effects of human likeness and purchase intention. The participants were 311 AI speaker users from South Korea. The results demonstrate how the direct effect and mediating effect of human likeness, attachment, and perceived interactivity on AI speakers boost purchase intention, thus providing meaningful implications for AI-driven marketing academics and practitioners. | Kim, Juran; Kang, Seungmook; Bae, Joonheui | Jeonju Univ, Dept Business Adm, Mkt, 518 Res Bldg,303 Cheonjamro, Jeonju 55069, South Korea; Jeonju Univ, Dept Game Contents, Arts Hall Annex Room 303,303 Cheonjamro, Jeonju 55069, Jeonbuk, South Korea; Kyungpook Natl Univ, Sch Business Adm, Daegu, South Korea | Bae, Joonheui/JXM-6789-2024 | 24074436200; 57210973804; 57202349513 | jrkim@jj.ac.kr;xevious@jj.ac.kr;regina721@knu.ac.kr; | JOURNAL OF BUSINESS RESEARCH | J BUS RES | 0148-2963 | 1873-7978 | 144 | SSCI | BUSINESS | 2022 | 11.3 | 8.8 | 3.11 | 2025-06-25 | 60 | 66 | Artificial intelligence; AI speaker; Human likeness; Attachment; Perceived interactivity | UNCANNY VALLEY; BRAND ATTACHMENT; CONSUMERS; ATTENTION; ROBOTS; ENDORSEMENTS; PERCEPTIONS; PERSONALITY; CONSISTENCY; EXPERIENCE | AI speaker; Artificial intelligence; Attachment; Human likeness; Perceived interactivity | English | 2022 | 2022-05 | 10.1016/j.jbusres.2022.02.047 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Hydrangea macrophylla and Thunberginol C Attenuate Stress-Induced Anxiety in Mice | Stress is an important neurological input for successful life. However, chronic stress and stress hormones could be a cause of various neurological disorders including anxiety disorders. Therefore, there have been many efforts to find effective materials for curing stress-induced neurological disorders. In this study, we examined the effect of Hydrangea macrophylla (HM) on corticosterone-induced neurotoxicity, stress-induced anxiety in mice and suggested a possible active ingredient of HM. HM protected cortical neurons against neurotoxicity of corticosterone (CORT), a stress hormone. HM also blocked CORT-induced hippocampal synaptic deficit via regulating Akt signaling. Oral administration of HM improved chronic restraint stress-induced anxiety in Elevated Plus maze test along with reduction of plasma corticosterone and TNF-alpha levels. Moreover, HM reduced stress-induced neuroinflammation and oxidative stress. Thunberginol C, an active ingredient of HM, also prevented CORT-induced neuronal cell death and restraint stress-induced anxiety. Moreover, thunberginol C reduced plasma TNF-alpha level and neuroinflammation and oxidative stress. Collectively, HM could be a good candidate for preventing stress-induced neurological disorders and thunberginol C may be an active ingredient of HM for this purpose. | Lee, Jihye; Kwon, Huiyoung; Cho, Eunbi; Jeon, Jieun; Lee, In-Kyu; Cho, Wan-Seob; Park, Se Jin; Lee, Seungheon; Kim, Dong Hyun; Jung, Ji Wook | Kyungpook Natl Univ, Sch Med, Div Endocrinol, Daegu 41944, South Korea; Dong A Univ, Grad Sch, Dept Hlth Sci, Busan 49315, South Korea; Konkuk Univ, Dept Pharmacol, Seoul 05029, South Korea; Konkuk Univ, Dept Adv Translat Med, Sch Med, Seoul 05029, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu 41944, South Korea; Kangwon Natl Univ, Sch Nat Resources & Environm Sci, Dept Food Biotechnol & Environm Sci, Chunchon 24341, South Korea; Jeju Natl Univ, Dept Marine Life Sci, Jeju 63243, South Korea; Daegu Haany Univ, Coll Herbal Bioind, Dept Herbal Med Pharmacol, Kyungsan 38610, South Korea | ; Lee, In-Kyu/AAR-6374-2021; Lee, Sangyeop/M-8307-2017; Cho, Wanseob/AAP-5991-2020; Lee, Seungheon/E-8866-2016; Kim, Dong Hyun/AEC-4494-2022 | 57269039200; 57195999296; 57202281620; 57202281465; 36071537600; 7401774754; 59081818000; 57203597100; 57222647956; 57199983943 | lghlovely@naver.com;kwonhuiyoung@naver.com;bee2634@naver.com;ji6785@naver.com;leei@knu.ac.kr;wcho@dau.ac.kr;sejinpark@kangwon.ac.kr;slee76@jejunu.ac.kr;mose79@kku.ac.kr;jwjung@dhu.ac.kr; | ANTIOXIDANTS | ANTIOXIDANTS-BASEL | 2076-3921 | 11 | 2 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY | 2022 | 7 | 8.8 | 0.48 | 2025-06-25 | 4 | 5 | Hydrangea macrophylla; thunberginol C; corticosterone; restraint stress; anxiety; synaptic plasticity | CHRONIC CORTICOSTERONE TREATMENT; SYNAPTIC PLASTICITY; DULCIS FOLIUM; NEUROINFLAMMATION; ACTIVATION; DEPRESSION; LEAVES; NEUROGENESIS; HIPPOCAMPUS; MECHANISMS | Anxiety; Corticosterone; Hydrangea macrophylla; Restraint stress; Synaptic plasticity; Thunberginol C | English | 2022 | 2022-02 | 10.3390/antiox11020234 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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