연구성과로 돌아가기
2023 연구성과 (37 / 285)
※ 컨트롤 + 클릭으로 열별 다중 정렬 가능합니다.
Excel 다운로드
| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ○ | ○ | Article | Is Sex Tourism Intention Uncontrollable? The Moderating Effects of Ethics and Law | This study explores one of the biggest social issues in South Korea, that is, sex tourism, which is illegal but remains in high demand. The study recruited a total of 1,003 respondents, whose responses were analyzed to understand their intentions for sex tourism. Study 1 revealed that sex tourism intention was largely influenced by subjective norms and moderated by ethical awareness and knowledge of illegality. In Study 2, sex tourism intention non-significantly differed across three scenarios of traveling, namely, to a general destination; to an area where prostitution is legal by local law; and with companions with positive opinions about sex tourism. However, Studies 3 and 4 found that the extent to which reminders and warnings about ethics and illegality reduced sex tourism intention differed according to the scenario. The results suggest that sex tourism intention is conditional and controllable, and, thus, government interventions are justified. | Jeong, Ji Youn; Lee, Kyung-Yur | Kyungpook Natl Univ, Dept Tourism, Sangju, South Korea; Hanyang Cyber Univ, Dept Tourism & Airline Management, 220 Wangsimni Ro, Seoul 04763, South Korea | ; Jeong, Ji Youn/KBB-3881-2024 | 57190002456; 57210286937 | kyungyur@gmail.com; | JOURNAL OF TRAVEL RESEARCH | J TRAVEL RES | 0047-2875 | 1552-6763 | 62 | 3 | SSCI | HOSPITALITY, LEISURE, SPORT & TOURISM | 2023 | 8 | 6.1 | 0.37 | 2025-06-25 | 2 | 4 | sex tourism; ethics; illegality; South Korea; prostitution | FEMALE TOURISTS; PROSTITUTION; BEHAVIOR; TRAFFICKING; DISPERSAL; ROMANCE; DESIRES | ethics; illegality; prostitution; sex tourism; South Korea | South Korea; ethics; knowledge; prostitution; tourism; tourist destination | English | 2023 | 2023-03 | 10.1177/00472875221093771 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Microstructural characteristics and bending properties of extruded SEN9 and SEN11 magnesium sheets | Mg-Al-based alloys with small amounts of Ca and Y, referred to as stainless, environment-friendly, nonflammable (SEN) alloys, exhibit significantly improved resistance to corrosion and ignition compared to commercial Mg alloys. This study investigates the microstructural characteristics and bending properties of extruded sheets of Mg-(9, 11)Al-1Zn-0.3Mn-0.3Ca-0.2Y alloys (SEN9 and SEN11). These sheets contain particles containing Ca or Y, such as Al2Y, Al2Ca, Al8Mn4Y, and Al-Ca-Zn phases, along with dynamically precipitated Mg17Al12 particles. In the SEN9 sheet, Mg17Al12 particles are distributed in a band-like pattern along the extrusion direction, whereas in the SEN11 sheet, a more uniform distribution of abundant Mg17Al12 particles is observed. In both sheets, a macrocrack initiates on the bottom surface of a specimen and propagates into the specimen at an angle of approximately 35 degrees during three-point bending tests. The SEN11 sheet exhibits a higher bending yield strength (by 27%) than the SEN9 sheet, primarily due to the stronger grain-boundary and particle hardening effects in the former, resulting from finer grains and a greater number of particles. In the SEN9 sheet, sharp deformation twins and subsequent cracks along these twins are formed during bending. Meanwhile, in the SEN11 sheet, the numerous Mg17Al12 particles induce stress concentration during bending, ultimately leading to premature bending failure before the formation of twins. As a result, the SEN11 sheet exhibits a 59% lower bending formability compared to the SEN9 sheet. | Kim, Hyun Ji; Lee, Gyo Myeong; Kim, Young Min; Bae, Jun Ho; Yu, Hui; Park, Sung Hyuk | Kyungpook Natl Univ, Sch Mat Sci & Engn, Daegu 41566, South Korea; Korea Inst Mat Sci, Dept Magnesium, Chang Won 51508, South Korea; Hebei Univ Technol, Sch Mat Sci & Engn, Tianjin 300130, Peoples R China | Park, Sung-Hyuk/AAE-6726-2022; Kim, Young Min/HCH-5414-2022; Kim, Hyunjin/MDS-5282-2025 | 59866513600; 57222810183; 58795669000; 36900467300; 7405855938; 54786002500 | sh.park@knu.ac.kr; | JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T | J MATER RES TECHNOL | 2238-7854 | 2214-0697 | 27 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING | 2023 | 6.2 | 6.1 | 0.11 | 2025-06-25 | 2 | 1 | Magnesium alloy; Extrusion; Secondary phase; Microstructure; Bending | MECHANICAL-PROPERTIES; AZ91 ALLOY; IMPROVEMENT; BEHAVIOR; TEMPERATURE; EVOLUTION; TENSILE; CA | Bending; Extrusion; Magnesium alloy; Microstructure; Secondary phase | Aluminum alloys; Aluminum corrosion; Bending (deformation); Bending (forming); Bending strength; Bending tests; Binary alloys; Calcium alloys; Corrosion resistance; Corrosion resistant alloys; Extrusion; Grain boundaries; Manganese alloys; Ternary alloys; Zinc alloys; Bending; Bending properties; Characteristic properties; Environment friendly; Magnesium sheets; Mg Al based alloys; Mg alloy; Microstructural characteristics; Non-flammable; Secondary phase; Magnesium alloys | English | 2023 | 2023 (NOV-DEC) | 10.1016/j.jmrt.2023.11.215 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | PEX13 prevents pexophagy by regulating ubiquitinated PEX5 and peroxisomal ROS | Peroxisomes are rapidly degraded during amino acid and oxygen deprivation by a type of selective autophagy called pexophagy. However, how damaged peroxisomes are detected and removed from the cell is poorly understood. Recent studies suggest that the peroxisomal matrix protein import machinery may serve double duty as a quality control machinery, where they are directly involved in activating pexophagy. Here, we explored whether any matrix import factors are required to prevent pexophagy, such that their loss designates peroxisomes for degradation. Using gene editing and quantitative fluorescence microscopy on culture cells and a zebrafish model system, we found that PEX13, a component of the peroxisomal matrix import system, is required to prevent the degradation of otherwise healthy peroxisomes. The loss of PEX13 caused an accumulation of ubiquitinated PEX5 on peroxisomes and an increase in peroxisome-dependent reactive oxygen species that coalesce to induce pexophagy. We also found that PEX13 protein level is downregulated to aid in the induction of pexophagy during amino acid starvation. Together, our study points to PEX13 as a novel pexophagy regulator that is modulated to maintain peroxisome homeostasis. | Demers, Nicholas D.; Riccio, Victoria; Jo, Doo Sin; Bhandari, Sushil; Law, Kelsey B.; Liao, Weifang; Kim, Choy; McQuibban, G. Angus; Choe, Seong-Kyu; Cho, Dong-Hyung; Kim, Peter K. | Hosp Sick Children, Peter Gilgan Ctr Res & Learning, Cell Biol Program, Toronto, ON, Canada; Univ Toronto, Dept Biochem, Toronto, ON, Canada; Kyungpook Natl Univ, Sch Life Sci, BK21 Four Knu Creat Biores Grp, Daegu, South Korea; Wonkwang Univ, Sch Med, Dept Microbiol, Iksan, South Korea; Gwangju Inst Sci & Technol, Dept Biomed Sci & Engn, Gwangju, South Korea; Wonkwang Univ, Sch Med, Dept Microbiol, 460 Iksan Dae Ro, Iksan 54538, Jeonbuk, South Korea; Kyungpook Natl Univ, Cho Grad Sch Life Sci, 80 Daehakro Bukgu, Daegu 41566, South Korea; Hosp Sick Children, Cell Biol Program, 686 Bay St 19-9410, Toronto, ON M5G 0A4, Canada | ; Choi, Hye Rin/JDV-9065-2023 | 57207303624; 57207306560; 56335489800; 56179524500; 55654142900; 57222749615; 58040568400; 57203237047; 7101751727; 35093684400; 24776060900 | seongkyu642@wku.ac.kr;dhcho@knu.ac.kr;pkim@sickkids.ca; | AUTOPHAGY | AUTOPHAGY | 1554-8627 | 1554-8635 | 19 | 6 | SCIE | CELL BIOLOGY | 2023 | 14.6 | 6.1 | 4.1 | 2025-06-25 | 33 | 30 | Peroxisomes; PEX13; pexophagy; reactive oxygen species; PEX5; selective autophagy; ubiquitin; zebrafish | MAMMALIAN PEROXISOMES; AUTOPHAGIC DEGRADATION; RECEPTOR; IMPORT; BIOGENESIS; DEPLETION; SURVIVAL; DOCKING; BINDING; MATRIX | Peroxisomes; PEX13; PEX5; pexophagy; reactive oxygen species; selective autophagy; ubiquitin; zebrafish | Actins; Amino Acids; Animals; Autophagy; Fibroblasts; Humans; Leucine; Lysine; Macroautophagy; Membrane Proteins; Mice; Oxygen; Peroxisomes; Reactive Oxygen Species; Sirolimus; Ubiquitin; Zebrafish; ABC transporter; ABC transporter D3; acetylcysteine; amino acid; autophagy related protein 5; cell protein; chloroquine; hydroxychloroquine; peroxin; peroxin 1; peroxin 10; peroxin 12; peroxin 13; peroxin 14; peroxin 19; peroxin 26; peroxin 6; peroxisomal targeting signal 1 receptor; peroxisome biogenesis factor 2; proteasome; reactive oxygen metabolite; red fluorescent protein; sirolimus; ubiquitinated protein; unclassified drug; actin; amino acid; leucine; lysine; membrane protein; oxygen; PEX13 protein, human; reactive oxygen metabolite; ubiquitin; adult; adulthood; animal cell; Article; autophagosome; cell fractionation; cell viability; cellular distribution; controlled study; CRISPR-CAS9 system; cytosolic fraction; down regulation; embryo; female; fluorescence intensity; fluorescence microscopy; gene editing; gene loss; gene mutation; HEK293 cell line; HeLa cell line; human; human cell; hypothesis; immunoblotting; immunofluorescence microscopy; immunoprecipitation; lipid storage; live cell imaging; membrane marker; mouse; nonhuman; oxidative stress; peroxisome; pexophagy; protein degradation; protein depletion; protein localization; T-REx-293 cell line; transgenic zebrafish; ubiquitination; upregulation; animal; fibroblast; macroautophagy; metabolism; peroxisome; physiology; zebra fish | English | 2023 | 2023-06-03 | 10.1080/15548627.2022.2160566 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Physical, structural, thermal, and mechanical features combined with neutron and gamma radiation attenuation qualities of Sm2O3 doped transparent borate-rich glasses | Current work presents the synthesis of B2O3-Gd2O3-Li2O-Na2O-LiF-Sm2O3 glass system via melt-quench approach and scrutiny of its mechanical, thermal, structural, physical, and nuclear radiation attenuation aspects. Raman scattering and Fourier transform infrared spectra revealed B-O stretching modes of BO4 groups linked to BO3 units with nonbridging oxygen atoms and BO3 and BO4 units' existence in the glass structure. By differential scanning calorimetry, glass transition and crystallization temperatures are identified. Relevant analysis showed all glasses' good thermal stability where glass tran-sition temperature varied at 372-407 degrees C range. SR (fast neutron removal cross-section) and for energy 0.025 eV neutrons 0-T (total cross-section) are computed. In all glasses, 49.25 B2O3-10Gd2O3-10Li2O-10Na2O-20LiF-0.75Sm2O3 (mol%) sample holds higher SR (= 0.10207 cm-1). 48B2O3-10Gd2O3-10Li2O-10Na2O-20LiF-2Sm2O3 (mol%) glass possesses greater 0-T (= 736.675 cm-1) for thermal neutrons, hinting at added Sm2O3's favorable in-fluence as Sm owns a better ability for neutron absorption than B. By Phy-X/PSD, m/r (mass attenuation coefficient) is obtained at photon energy extent 15 keV-15 MeV. Sm2O3 in-clusion from 0 to 2 mol% minorly enhanced the mu/r values. Buildup factors estimated via geometric progression fitting method at 1-40 mean free path and energy 0.015-15 MeV span are maximal at medium energy region owing to Compton scattering process. 48B2O3-10Gd2O3-10Li2O-10Na2O-20LiF-2Sm2O3 (mol%) sample shows superior 7-ray blocking capacity in all glasses, suggesting Sm2O3's positive effect. Elastic moduli and Poisson's ratio are computed theoretically by bond compression and Makishima-Mackenzie models. It is identified that all glasses could tolerate longitudinal stress over shear stress. (c) 2022 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | Lakshminarayana, G.; Dong, M. G.; Al-Buriahi, M. S.; Rekik, Najeh; Lee, Dong-Eun; Yoon, Jonghun; Park, Taejoon | Kyungpook Natl Univ, Intelligent Construct Automat Ctr, 80, Daehak Ro, Daegu 41566, South Korea; Northeastern Univ, Dept Resource & Environm, Shenyang 110819, Peoples R China; Sakarya Univ, Dept Phys, Sakarya, Turkey; Univ Hail, Coll Sci, Phys Dept, Hail 55476, Saudi Arabia; Univ Alberta, Dept Chem, Edmonton, AB T6G 2G2, Canada; Kyungpook Natl Univ, Sch Architecture Civil Environm & Energy, 1370, Sangyeok Dong, Daegu 702701, South Korea; Hanyang Univ, ACE Ctr, Dept Mech Engn, FOUR ER BK21, 55 Hanyangdaehak Ro, Ansan 15588, Gyeonggi Do, South Korea; Hanyang Univ, Dept Robot Engn, 55 Hanyangdaehak Ro, Ansan 15588, Gyeonggi Do, South Korea | Al-Buriahi, M.S./HKW-2385-2023; Rekik, Najeh/AAY-8625-2021; DONG, Mengge/AEN-2933-2022 | 57194637883; 56082379700; 57191693608; 22136167500; 56605563300; 56449838900; 55717001200 | gandham@knu.ac.kr;dolee@knu.ac.kr;yooncsmd@gmail.com;taejoon@hanyang.ac.kr; | JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T | J MATER RES TECHNOL | 2238-7854 | 2214-0697 | 22 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING | 2023 | 6.2 | 6.1 | 1.78 | 2025-06-25 | 16 | 17 | Raman spectroscopy; Differential scanning calorimetry; Neutron radiation; Phy-X; PSD software; Gamma radiation | SHIELDING PERFORMANCE; POISSONS RATIO; ELASTIC-MODULI; BULK MODULUS; OXIDE; CODE; MICROSTRUCTURE; LUMINESCENCE; PARAMETERS; LASER | B<sub>2</sub>O<sub>3</sub>-rich glasses; Differential scanning calorimetry; Gamma radiation; Neutron radiation; Phy-X/PSD software; Raman spectroscopy | Calorimeters; Fourier series; Fourier transform infrared spectroscopy; Gamma rays; Glass; Glass transition; Lithium compounds; Neutrons; Raman spectroscopy; Sodium compounds; B2O3-rich glass; Energy; Glass transition temperature Tg; Mechanical feature; Neutron radiations; Phy-X/PSD software; Physical features; Radiation attenuation; Structural feature; Thermal features; Differential scanning calorimetry | English | 2023 | 2023 (JAN-FEB) | 10.1016/j.jmrt.2022.11.177 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Article | Powder-bed-based 3D printing with cement for sustainable casting | 3D printing allows for the cost-effective fabrication of moulds and can cast complex shapes. In this study, alumina cement and fine aggregates for refractories were used as the main raw materials, and saturation was adjusted to an appropriate level to control the cement binder mixture for sand casting. For cast iron, the mould must withstand temperatures of up to 1400 °C and must exhibit sufficient strength, gas permeability, and thermochemical durability at high temperatures. To accomplish these requirements, 3D printing powder was prepared by adjusting the ratio of fine aggregate (D50: 30 μm) and an even finer cement component (D50: 4 μm). To improve the moulding quality, a green body was used to optimise the cement admixtures to increase the strength, and the saturation level of the 3D printer was adjusted for dimensional accuracy. The high-temperature durability of the mould was evaluated by measuring its strength after heat treatment, using Simultaneous Thermal Analysis (TG-DSC), and through dimensional stability assessment. In addition, the pores of the specimens were analysed through microscale X-ray tomography. The surface resolution and tolerance of the final casting were determined by a 3D image roughness test using a surface roughness scanner. The cement exhibited the shortest curing time and the highest strength when the mass ratio of CA (CaO·Al2O3) to C12A7 (12CaO·7Al2O3) was 8:2. The final mixing mass ratio of cement to the fine aggregate was 8:2, which was determined based on the relationship between flowability and powder bed surface quality. The results proved the high-temperature thermal stability of the 3D-printed mould, which showed a total mass reduction of less than 3% and a low coefficient of linear expansion up to 1300 °C. Consequently, the suitability of the 3D-printed moulded body, composed of casting sand with cement as a binder, for casting at temperatures >1400 °C was demonstrated. Additionally, the final printed porous mould de-powdered easily, and its recyclability was verified by strength testing various mass ratios of fresh and recycled powder. Therefore, through optimisation of the material combinations and adjustment of the 3D printing process parameters, optimal gas permeability and moulding resolution could be achieved without any casting defect, while maintaining handling strength. The findings of this study demonstrate the potential of expanding the scope of powder-bed-based 3D printing of cement material to the casting market. © 2022 The Author(s). | Chun, Seung-Yeop; Kim, Su-Jin; Kim, Woon-Gi; Lee, Geumyeon; Lee, Myeung-Jin; Ye, Bora; Kim, Hong-Dae; Lee, Jeong Hun; Kim, Taewook | Advanced Forming Process RandD Group, Korea Institute of Industrial Technology, Ulsan, 44413, South Korea; Industrial Environment Green Deal Agency, Korea Institute of Industrial Technology, Ulsan, 44413, South Korea; Industrial Environment Green Deal Agency, Korea Institute of Industrial Technology, Ulsan, 44413, South Korea; Division of Management, Korea Marine Equipment Research Institute, Busan, 49111, South Korea; Industrial Environment Green Deal Agency, Korea Institute of Industrial Technology, Ulsan, 44413, South Korea; Industrial Environment Green Deal Agency, Korea Institute of Industrial Technology, Ulsan, 44413, South Korea; Industrial Environment Green Deal Agency, Korea Institute of Industrial Technology, Ulsan, 44413, South Korea; Advanced Forming Process RandD Group, Korea Institute of Industrial Technology, Ulsan, 44413, South Korea; Department of Energy Chemical Engineering, Kyungpook National University (KNU), Sangju, 37224, South Korea, Department of Advanced Science and Technology Convergence, Kyungpook National University (KNU), Sangju, 37224, South Korea | 57215651466; 57204036008; 57781172300; 57223329686; 57207730158; 57188965283; 35205685400; 54785958500; 57030752600 | pocion@kitech.re.kr;taewook@knu.ac.kr; | Journal of Materials Research and Technology | J MATER RES TECHNOL | 2238-7854 | 2214-0697 | 22 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING | 2023 | 6.2 | 6.1 | 1 | 2025-06-25 | 9 | 3DP; Additive manufacturing; Alumina cement; Ink-jet; Mould | 3D printing; Aluminum oxide; Cast iron; Casting; Cements; Cost effectiveness; Durability; Molding; Molds; Printing presses; Surface roughness; System stability; Thermoanalysis; Thermodynamic stability; 3-D printing; 3D-printing; 3DP; Complex shapes; Cost-effective fabrication; Fine aggregates; Ink jet; Mass ratio; Mold; Powder bed; Alumina | English | Final | 2023 | 10.1016/j.jmrt.2022.12.102 | 바로가기 | 바로가기 | 바로가기 | ||||||||
| ○ | ○ | Article | Recrystallization mechanisms and texture evolution of AZ31 alloy by gradient caliber rolling | A single-pass gradient caliber rolling of a conical-shaped AZ31 Mg alloy was performed at 723 K to obtain a transitional microstructure with strain ranging from 0 to 30%. The recrystallization mechanisms involved and the evolution of texture during the deforma-tion were specifically investigated. The results show that the recrystallization extent in-creases with strain. The isolated fine grains at 5% strain were formed by the particle stimulated nucleation, which tended to randomize the texture. A large number of {10 1 2} extension twins at 10% strain effectively divided and refined the grains, but no twin -induced dynamic recrystallization was found. Some {10 1 1}-{10 1 2} double twins and {10 1 1} compression twins were activated at 15% strain, which to a certain extent facilitated dynamic recrystallization nucleation. Meanwhile, the continuous dynamic recrystalliza-tion and discontinuous dynamic recrystallization mechanisms also occurred at various strains. In particular, the discontinuous dynamic recrystallization was more prominent due to the higher deformation temperature, and the recrystallization grains were evidently different from the orientations of their parent grains. In addition, with increasing strain, the overall texture component of the deformed samples gradually transitioned from the initial (0001) basal texture to the [11 2 0]-[10 1 0] non-fiber component, then tended to form the [11 2 0] fiber orientation eventually.(c) 2023 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | Yu, Hui; Wang, Dongliang; Liu, Ya; Liu, Yu; Huang, Lixin; Jiang, Binan; Park, Sunghyuk; Yu, Wei; Yin, Fuxing | Hebei Univ Technol, Sch Mat Sci & Engn, Tianjin Key Lab Mat Laminating Fabricat & Interfac, Tianjin 300130, Peoples R China; CIT Dicastal Co Ltd, Qinhuangdao 066011, Peoples R China; PLA AAAAD, Hefei 230031, Peoples R China; Kyungpook Natl Univ, Sch Mat Sci & Engn, Daegu 41566, South Korea; Hefei Univ Technol, Sch Mat Sci & Engn, Hefei 200039, Peoples R China; Guangdong Acad Sci, Inst New Mat, Guangzhou 510650, Peoples R China | Yu, Wei/HHR-9148-2022; Yin, Fuxing/AAE-4626-2020; yu, hui/H-8481-2012; Yu, Hui/H-8481-2012 | 7405855938; 57924092500; 59854116100; 58610668600; 57215233280; 57061440600; 54786002500; 57221964647; 59461355900 | huiyu@vip.126.com;yuwei52213@163.com; | JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T | J MATER RES TECHNOL | 2238-7854 | 2214-0697 | 23 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING | 2023 | 6.2 | 6.1 | 1 | 2025-06-25 | 10 | 9 | AZ31 alloy; Gradient caliber rolling; Recrystallization mechanism; Texture evolution | GRAIN-BOUNDARY SEGREGATION; MAGNESIUM ALLOY; DYNAMIC RECRYSTALLIZATION; 2ND-PHASE PARTICLES; TENSILE PROPERTIES; MG ALLOY; MICROSTRUCTURE; BEHAVIOR; DEFORMATION; TWINS | AZ31 alloy; Gradient caliber rolling; Recrystallization mechanism; Texture evolution | Dynamic recrystallization; Dynamics; Magnesium alloys; Nucleation; Rolling; Textures; AZ31 alloy; AZ31 Mg alloys; Caliber rolling; Discontinuous dynamic recrystallization; Dynamic recrystallisation; Gradient caliber rolling; Recrystallization mechanisms; Recrystallization texture; Single pass; Texture evolutions; Strain | English | 2023 | 2023 (MAR-APR) | 10.1016/j.jmrt.2023.01.044 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Meeting Abstract | Asian population-based visceral adiposity indices outperform western population-based those as indicators of CKD in a Korean population | Kim, H.; Jin, J.; Ha, B.; Kim, N.; Park, K. -G. | Kyungpook Natl Univ Hosp, Dept Internal Med, Daegu, South Korea | DIABETOLOGIA | DIABETOLOGIA | 0012-186X | 1432-0428 | 66 | SUPPL 1 | SCIE | ENDOCRINOLOGY & METABOLISM | 2023 | 8.4 | 6.2 | 0 | English | 2023 | 2023-09 | 바로가기 | 바로가기 | ||||||||||||||||
| ○ | ○ | Editorial Material | Characterization of the novel HLA-DRB1*14:252 allele in a Korean individual by next-generation sequencing | HLA-DRB1*14:252 differs from HLA-DRB1*14:03:01 by one nucleotide substitution in codon 9 in exon 2. | Bae, Hye Gyung; Jung, Hee-Yeon; Won, Dong Il | Kyungpook Natl Univ, Sch Med, Dept Clin Pathol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ Hosp, Dept Lab Med, 130 Dongdeok Ro, Daegu 41944, South Korea | Jung, Hee-Yeon/AFB-8578-2022 | 57816033400; 57196396467; 7005166517 | wondi@knu.ac.kr; | HLA | HLA | 2059-2302 | 2059-2310 | 102 | 1 | SCIE | CELL BIOLOGY;IMMUNOLOGY;PATHOLOGY | 2023 | 6.5 | 6.2 | 0.28 | 2025-06-25 | 2 | 2 | HLA; HLA-DRB1*14:252; new allele; next-generation sequencing | HLA; HLA-DRB1*14:252; new allele; next-generation sequencing | Alleles; Exons; High-Throughput Nucleotide Sequencing; HLA-DRB1 Chains; Humans; Republic of Korea; HLA A24 antigen; HLA antigen class 2; HLA B antigen; HLA C antigen; HLA DPA1 antigen; HLA DPB1 antigen; HLA DQA1 antigen; HLA DQB1 antigen; HLA DRB1 antigen; HLA DRB3 antigen; unclassified drug; HLA DRB1 antigen; aged; allele; Article; chronic kidney failure; codon; diabetic nephropathy; exon; graft recipient; high throughput sequencing; HLA system; HLA typing; human; kidney graft; Korean (people); male; nucleic acid base substitution; nucleotide sequence; allele; genetics; South Korea | English | 2023 | 2023-07 | 10.1111/tan.15031 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Discovery of cellular and genetic signatures of immune tolerance in kidney transplant recipients through single cell RNA sequencing analysis | The objective of this study was to uncover distinct cellular and genetic signatures of transplant operational tolerance (TOT) in kidney transplant recipients (KTRs) through single cell RNA sequencing (scRNA-seq) using peripheral blood mononuclear cells (PBMCs). PBMCs were isolated from 12 KTRs, including those with TOT (TOT, n = 4), stable allograft function on maintenance immunosuppression (STA, n = 4) and biopsy-proven allograft rejection (BPAR, n = 4). ScRNA-seq of PBMCs was analyzed using 20 cell surface marker antibody sequencing to annotate clusters and 399 immune response panel to identify gene expression. Differences in cellular distribution and gene expression were compared among the three groups. Heatmap hierarchical clustering showed that overall cellular distribution pattern was distinct in TOT in comparison with those in the other two groups, with the proportion of B cells being higher in TOT, attributed to immature B cell fraction (TOT vs. STA vs. BPAR: 4.61% vs. 1.27% vs. 2.53%, p = 0.01). Transcript analysis of B cells revealed that genes involved in allo-immune pathway were downregulated in TOT. In T cell subset analysis, the proportion of naive T cells and regulatory T cells (Tregs) was increased. In transcript analysis, genes associated with inflammation were decreased, while expression levels of CCR6 in Tregs were increased in TOT. Proportions of NKT and NK cells were increased in TOT than in the other two groups. This study showed that TOT has distinct cellular and genetic signatures such as increases of immature B cells, naive T cells and Tregs and high expression levels of CCR6 in Tregs. | Bae, Hyunjoo; Lee, Hanbi; Ko, Eun Jeong; Kim, Chan-Duck; Lee, Sang-Ho; Yang, Chul Woo; Oh, Eun-Jee; Chung, Byung Ha | Catholic Univ Korea, Coll Med, Grad Sch, Dept Biomed Sci, Seoul, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Internal Med, 222 Banpo Daero, Seoul 06591, South Korea; Catholic Univ Korea, Coll Med, Transplantat Res Ctr, Seoul, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Convergent Res Consortium Immunol Dis, Seoul, South Korea; Kyungpook Natl Univ Hosp, Dept Internal Med, Div Nephrol, Daegu, South Korea; Kyung Hee Univ Hosp Gandong, Dept Internal Med, Div Nephrol, Seoul, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Lab Med, 222 Banpo Daero, Seoul 06591, South Korea | Ko, Eun-Jeong/AAV-1077-2021; Lee, Sang Ho/HNC-3447-2023 | 57209823411; 57223310104; 57194720455; 8558530700; 55890136000; 7407743404; 16417408700; 57201863822 | ejoh@catholic.ac.kr;chungbh@catholic.ac.kr; | HLA | HLA | 2059-2302 | 2059-2310 | 102 | 3 | SCIE | CELL BIOLOGY;IMMUNOLOGY;PATHOLOGY | 2023 | 6.5 | 6.2 | 0.42 | 2025-06-25 | 3 | 3 | CCR6; immune tolerance; kidney transplantation; peripheral blood mononuclear cells; single-cell analysis | REGULATORY T-CELLS; OPERATIONAL TOLERANCE; ALLOGRAFT-REJECTION; NKT CELLS; IDENTIFICATION; EXPRESSION; BIOMARKERS; MARKERS | CCR6; immune tolerance; kidney transplantation; peripheral blood mononuclear cells; single-cell analysis | Alleles; Graft Rejection; Humans; Immune Tolerance; Kidney Transplantation; Leukocytes, Mononuclear; Sequence Analysis, RNA; Transplant Recipients; antibody; basiliximab; cell surface marker; chemokine receptor CCR6; mycophenolate mofetil; steroid; tacrolimus; thymocyte antibody; adult; alloimmunity; Article; B lymphocyte subpopulation; blood sampling; cell fractionation; cell isolation; cell level; cellular distribution; clinical article; comparative study; controlled study; cross-sectional study; down regulation; end stage renal disease; female; gene expression; graft recipient; human; human cell; human tissue; immune response; immunological tolerance; immunosuppressive treatment; inflammation; kidney allograft; kidney biopsy; kidney graft rejection; kidney transplantation; maintenance therapy; male; middle aged; natural killer cell; natural killer T cell; peripheral blood mononuclear cell; pre B lymphocyte; protein expression level; regulatory T lymphocyte; single cell RNA seq; T lymphocyte subpopulation; allele; genetics; graft rejection; immunological tolerance; mononuclear cell; RNA sequencing | English | 2023 | 2023-09 | 10.1111/tan.15061 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Article | Efficacy and Safety of Udenafil Once Daily in Patients with Erectile Dysfunction after Bilateral Nerve-Sparing Robot-Assisted Laparoscopic Radical Prostatectomy: A Randomized, Double-Blind, Placebo-Controlled Study | Purpose: To evaluate the efficacy and safety of udenafil 75 mg once daily in patients with erectile dysfunction following bilateral nerve-sparing robot-assisted laparoscopic radical prostatectomy (BNS-RALP). Materials and Methods: A multi-center, prospective, randomized, controlled, double-blind study was conducted. Among patients with localized prostate cancer with international index of erectile function-erectile function domain (IIEF-EF) score of 18 or higher before BNS-RALP, those who developed postoperative erectile dysfunction (IIEF-EF score 14 or less at 4 weeks after BNS-RALP) were enrolled. Enrolled patients were randomly assigned to the udenafil 75 mg daily group or the placebo group in a 2:1 ratio. Each subject was followed up at 8 weeks (V2), 20 weeks (V3), and 32 weeks (V4) to evaluate the efficacy and safety of udenafil. Results: In all, 101 patients were screened, of whom 99 were enrolled. Of the 99 patients, 67 were assigned to the experimental group and 32 to the control group. Ten (14.93%) patients in the experimental group and 10 (31.25%) in the control group dropped out of the study. After 32 weeks of treatment, IIEF-EF score of 22 or higher was seen in 36.51% (23/63) of patients in the experimental group and 13.04% (3/23) patients in the control group (p=0.021). The proportion of patients with IIEF-EF improvement of 25% or more compared to the baseline was 82.54% (52/63) in the experimental group and 62.96% (17/27) in the control group (p=0.058). Conclusions: Udenafil 75 mg once daily after BNS-RALP improved the erectile function without any severe adverse effects. | Chung, Jae Hoon; Kwon, Tae Gyun; Kwak, Cheol; Sung, Gyung Tak; Kim, Soo Dong; Cho, Jin Seon; Kim, Hyung Jin; Ahn, Hanjong; Jeon, Seong Soo | Sungkyunkwan Univ, Samsung Med Ctr, Dept Urol, Sch Med, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Urol, Daegu, South Korea; Seoul Natl Univ, Dept Urol, Coll Med, Seoul, South Korea; Dong A Univ, Dept Urol, Coll Med, Busan, South Korea; Hallym Univ, Hallym Univ Sacred Heart Hosp, Dept Urol, Coll Med, Anyang, South Korea; Jeonbuk Natl Univ, Res Inst Clin Med, Dept Urol, Med Sch,Jeonbuk Natl Univ Hosp, Jeonju, South Korea; Univ Ulsan, Dept Urol, Asan Med Ctr, Coll Med, Seoul, South Korea | ; Kwak, Cheol/J-2731-2012; Lee, Seung Eun/ABG-1607-2021 | hjahn@amc.seoul.kr;seongsoo.jeon@samsung.com; | WORLD JOURNAL OF MENS HEALTH | WORLD J MENS HEALTH | 2287-4208 | 2287-4690 | 41 | 3 | SCIE | ANDROLOGY;UROLOGY & NEPHROLOGY | 2023 | 4 | 6.2 | 4 | Phosphodiesterase 5 inhibitors; Prostatectomy; Prostatic neoplasms; Rehabilitation | NIGHTLY SILDENAFIL CITRATE; PENILE REHABILITATION; INTERNATIONAL INDEX; MANAGEMENT; VARDENAFIL; RECOVERY; CANCER; MEN; MULTICENTER; PREVENTION | English | 2023 | 2023-07 | 10.5534/wjmh.220057 | 바로가기 | 바로가기 | 바로가기 | |||||||||
| ○ | ○ | Article | Establishment of Prospective Registry of Active Surveillance for Prostate Cancer: The Korean Urological Oncology Society Database | Purpose: To establish a prospective registry for the active surveillance (AS) of prostate cancer (PC) using the Korean Urological Oncology Society (KUOS) database and to present interim analysis. Materials and Methods: The KUOS registry of AS for PC (KUOS-AS-PC) was organized in May 2019 and comprises multiple institutions nationwide. The eligibility criteria were as follows: patients with (1) pathologically proven PC; (2) pre-biopsy prostate-specific antigen (PSA) <= 20 ng/mL; (3) International Society of Urological Pathology (ISUP) grade 1 or 2 (no cribriform pattern 4); (4) clinical T stage <= T2c; (5) positive core ratio <= 50%; and (6) maximal cancer involvement in the core <= 50%. Detailed longitudinal clinical information, including multi-parametric magnetic resonance imaging and disease-specific outcomes, was recorded. Results: From May 2019 to June 2021, 296 patients were enrolled, and 284 were analyzed. The mean +/- standard deviation (SD) age at enrollment was 68.7 +/- 8.2 years. The median follow-up period was 11.2 months (5.9-16.8 mo). Majority of patients had pre-biopsy PSA <= 10 ng/mL (91.2%), PSA density <0.2 ng/mL2 (79.7%), ISUP grade group 1 (94.4%), single positive core (65.7%), maximal cancer involvement in the core <= 20% (78.1%), and clinical T stage of T1c or lower (72.9%). Fifty-two (18.3%) discontinued AS for various reasons. Interventions included radical prostatectomy (80.8%), transurethral prostatectomy (5.8%), primary androgen deprivation therapy (5.8%), radiation (5.8%), and focal therapy (1.9%). The mean +/- SD time to intervention was 8.9 +/- 5.2 months. The reasons for discontinuation included pathologic reclassification (59.6%), patient preference (25.0%), and radiologic reclassification (9.6%). Two (4.8%) patients with pathologic Gleason score upgraded to ISUP grade group 4, no biochemical recurrence. Conclusions: The KUOS established a successful prospective database of PC patients undergoing AS in Korea, named the KUOS-AS-PC registry. | Jung, Gyoohwan; Kim, Jung Kwon; Jeon, Seong Soo; Chung, Jae Hoon; Kwak, Cheol; Jeong, Chang Wook; Ahn, Hanjong; Joung, Jae Young; Kwon, Tae Gyun; Park, Sung Woo; Byun, Seok-Soo | Seoul Natl Univ, Bundang Hosp, Dept Urol, 82 Gumi Ro 173Beon Gil, Seongnam 13620, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Urol, Seoul, South Korea; Seoul Natl Univ, Seoul Natl Univ Hosp, Sch Med, Dept Urol, Seoul, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Urol, Seoul, South Korea; Natl Canc Ctr, Ctr Prostate Canc, Dept Urol, Goyang, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Urol, Daegu, South Korea; Pusan Natl Univ, Yangsan Hosp, Sch Med, Dept Urol, Yangsan, South Korea; Seoul Natl Univ, Coll Med, Dept Med Device Dev, Seoul, South Korea | ; Kwak, Cheol/J-2731-2012; Lee, Seung Eun/ABG-1607-2021; park, sung woo/JTS-5921-2023; Byun, Seok-Soo/J-5507-2012 | 56720069800; 36447570600; 7203005276; 59911114200; 7005639032; 8879131000; 8339679200; 57222985702; 15073765400; 57185889000; 7004818488 | seoksoo.byeon@gmail.com; | WORLD JOURNAL OF MENS HEALTH | WORLD J MENS HEALTH | 2287-4208 | 2287-4690 | 41 | 1 | SCIE | ANDROLOGY;UROLOGY & NEPHROLOGY | 2023 | 4 | 6.2 | 0.48 | 2025-06-25 | 2 | 2 | Active surveillance; Database; Prostate cancer; Prospective registry | TERM OUTCOMES; METHODOLOGY; UPDATE; BIOPSY; COHORT | Active surveillance; Database; Prospective registry; Prostate cancer | prostate specific antigen; active surveillance; aged; androgen deprivation therapy; Article; biochemical recurrence; cancer radiotherapy; controlled study; follow up; Gleason score; human; human tissue; major clinical study; male; multiparametric magnetic resonance imaging; outcome assessment; patient preference; prospective study; prostate biopsy; prostate cancer; prostatectomy; transurethral resection | English | 2023 | 2023-01 | 10.5534/wjmh.210163 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Optimal EV scheduling and voltage security via an online bi-layer steady-state assessment method considering uncertainties | Steady-state voltage security region (SVSR) is an important criterion that can intuitively and effectively evaluate the power system's operation security and overall safety margin. However, there is no literature on its application to electric vehicle (EV) proliferation. Since EV introduces dynamism and uncertainties to the grid, most existing indices cannot assess the grid accurately. Given this, we propose a load margin index (LMI) based on SVSR considering uncertainties. This is used to assess the impact of EV proliferation via a bi-layer optimal EV scheduling model. The upper layer of the model solves a dispatching plan for EV aggregators (EVA) by maximizing the LMI and minimizing the deviation between the upper and lower layer power schedules. The lower layer models each EV's charging/discharging strategy by minimizing the EV's operating cost, the EV user's target residual energy, and the deviation between the lower and upper layer schedules. We also employ a real-time scheduling plan to further adjust the day-ahead scheduling due to forecast errors. A case study based on the IEEE-33 node distribution network verifies the practicability and effectiveness of the proposed method. | Jin, Yuwei; Acquah, Moses Amoasi; Seo, Mingyu; Ghorbanpour, Samira; Han, Sekyung; Jyung, Taeyoung | Kyungpook Natl Univ, Elect & Elect Engn, Daegu 41566, South Korea; Keimyung Univ, Elect Energy Engn, Daegu 42601, South Korea; Korea Elect Power Corp Engineering& Construct KEPC, Gimcheon 39660, South Korea | Jin, Yuwei/LIR-2747-2024 | 57212253293; 57105816500; 57215358477; 57207109590; 36023785800; 22940595300 | jinyuwei91@gmail.com;amoasiacquah@gmail.com;mgseo1218@gmail.com;Samira.ghorbanpour@gmail.com;sekyung.han@gmail.com;tyjyung@kepco-enc.com; | APPLIED ENERGY | APPL ENERG | 0306-2619 | 1872-9118 | 347 | SCIE | ENERGY & FUELS;ENGINEERING, CHEMICAL | 2023 | 10.1 | 6.2 | 1.8 | 2025-06-25 | 14 | 18 | Steady-state voltage security region; Load margin index; Bi-layer scheduling model; EV aggregator | COORDINATED CONTROL; ELECTRIC VEHICLES; LOAD; STRATEGY; ALGORITHM; REGION; TIME | Bi-layer scheduling model; EV aggregator; Load margin index; Steady-state voltage security region | Electric load dispatching; Electric power distribution; Uncertainty analysis; Bi-layer; Bi-layer scheduling model; Electric vehicle aggregator; Load margin; Load margin index; Margin index; Scheduling models; Security region; Steady state voltage; Steady-state voltage security region; Voltage security; electric vehicle; electrical power; literature review; loading test; performance assessment; safety; Linear matrix inequalities | English | 2023 | 2023-10-01 | 10.1016/j.apenergy.2023.121356 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Pareto-based Dynamic Difficulty Adjustment of a competitive exergame for arm rehabilitation | Although Dynamic Difficulty Adjustment (DDA) in rehabilitation-based exergames features the conflicting objectives of intensity and performance, traditional DDA methods have only addressed this problem in terms of single or weighted objectives. Deviating from previous works, this work presents a Pareto-based DDA (PDDA) for a Competitive rehabilitation-based exergame which is capable of generating a set of trade-off solutions between the two conflicting objectives. Consequently, based on the rehabilitative needs, a unique solution is selected via the trade-off worth information of the generated solutions to modify the game parameters or difficulty. In order to evaluate the performance of the proposed PDDA, two experimental studies were conducted based on 12 and 10 unimpaired participants respectively. The first study which was aimed at evaluating the performance of the proposed PDDA in terms of the in-game parameters shows that the proposed PDDA is capable of generating multiple trade-off solutions as well as effectively adjust the game parameters or difficulty. The second study which was aimed at evaluating the proposed PDDA in term of user experience shows that PDDA demonstrate statistical difference with a random DDA method in terms of the Intrinsic Motivation Inventory (IMI) and the Flow Experience Measure (FEM) metrics. Since rehabilitation outcomes generally rely on both intensity and performance, the ability of the proposed PDDA to increase effort, enjoyment, competence, and flow will help to greatly facilitate frequent and intense exercise as well as performance in rehabilitation-based exergame. | Ajani, Oladayo S.; Mallipeddi, Rammohan | Kyungpook Natl Univ, Dept Artificial Intelligence, Daegu, South Korea | Mallipeddi, Rammohan/AAL-5306-2020; AJANI, Oladayo/HIR-9607-2022 | 57465126000; 25639919900 | mallipeddi.ram@gmail.com; | INTERNATIONAL JOURNAL OF HUMAN-COMPUTER STUDIES | INT J HUM-COMPUT ST | 1071-5819 | 1095-9300 | 178 | SCIE;SSCI | COMPUTER SCIENCE, CYBERNETICS;ERGONOMICS;PSYCHOLOGY, MULTIDISCIPLINARY | 2023 | 5.3 | 6.2 | 0.81 | 2025-06-25 | 5 | 6 | Dynamic Difficulty Adjustment; Exergame; Trade-off solutions; Pareto; Rehabilitation | MOTIVATION; INTENSITY; EXERCISE; GAMES | Dynamic Difficulty Adjustment; Exergame; Pareto; Rehabilitation; Trade-off solutions | Patient rehabilitation; Adjustment method; Arm rehabilitations; Conflicting objectives; Dynamic difficulty adjustment; Exergames; Game parameters; Pareto; Performance; Trade off; Tradeoff solution; Economic and social effects | English | 2023 | 2023-10 | 10.1016/j.ijhcs.2023.103100 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Tcf7l2 in hepatocytes regulates de novo lipogenesis in diet-induced non-alcoholic fatty liver disease in mice | Aims/hypothesis Non-alcoholic fatty liver disease (NAFLD) associated with type 2 diabetes may more easily progress towards severe forms of non-alcoholic steatohepatitis (NASH) and cirrhosis. Although the Wnt effector transcription factor 7-like 2 (TCF7L2) is closely associated with type 2 diabetes risk, the role of TCF7L2 in NAFLD development remains unclear. Here, we investigated how changes in TCF7L2 expression in the liver affects hepatic lipid metabolism based on the major risk factors of NAFLD development.Methods Tcf7l2 was selectively ablated in the liver of C57BL/6N mice by inducing the albumin (Alb) promoter to recombine Tcf7l2 alleles floxed at exon 5 (liver-specific Tcf7l2-knockout [KO] mice: Alb-Cre;Tcf7l2(f/f)). Alb-Cre;Tcf7l2(f/f) and their wild-type (Tcf7l2(f/f)) littermates were fed a high-fat diet (HFD) or a high-carbohydrate diet (HCD) for 22 weeks to reproduce NAFLD/NASH. Mice were refed a standard chow diet or an HCD to stimulate de novo lipogenesis (DNL) or fed an HFD to provide exogenous fatty acids. We analysed glucose and insulin sensitivity, metabolic respiration, mRNA expression profiles, hepatic triglyceride (TG), hepatic DNL, selected hepatic metabolites, selected plasma metabolites and liver histology. Results Alb-Cre;Tcf7l2(f/f) essentially exhibited increased lipogenic genes, but there were no changes in hepatic lipid content in mice fed a normal chow diet. However, following 22 weeks of diet-induced NAFLD/NASH conditions, liver steatosis was exacerbated owing to preferential metabolism of carbohydrate over fat. Indeed, hepatic Tcf7l2 deficiency enhanced liver lipid content in a manner that was dependent on the duration and amount of exposure to carbohydrates, owing to cell-autonomous increases in hepatic DNL. Mechanistically, TCF7L2 regulated the transcriptional activity of Mlxipl (also known as ChREBP) by modulating O-GlcNAcylation and protein content of carbohydrate response element binding protein (ChREBP), and targeted Srebf1 (also called SREBP1) via miRNA (miR)-33-5p in hepatocytes. Eventually, restoring TCF7L2 expression at the physiological level in the liver of Alb-Cre;Tcf7l2(f/f) mice alleviated liver steatosis without altering body composition under both acute and chronic HCD conditions.Conclusions/interpretation In mice, loss of hepatic Tcf7l2 contributes to liver steatosis by inducing preferential metabolism of carbohydrates via DNL activation. Therefore, TCF7L2 could be a promising regulator of the NAFLD associated with high-carbohydrate diets and diabetes since TCF7L2 deficiency may lead to development of NAFLD by promoting utilisation of excess glucose pools through activating DNL. | Lee, Da Som; An, Tae Hyeon; Kim, Hyunmi; Jung, Eunsun; Kim, Gyeonghun; Oh, Seung Yeon; Kim, Jun Seok; Chun, Hye Jin; Jung, Jaeeun; Lee, Eun-Woo; Han, Baek-Soo; Han, Dai Hoon; Lee, Yong-Ho; Han, Tae-Su; Hur, Keun; Lee, Chul-Ho; Kim, Dae-Soo; Kim, Won Kon; Park, Jun Won; Koo, Seung-Hoi; Seong, Je Kyung; Lee, Sang Chul; Kim, Hail; Bae, Kwang-Hee; Oh, Kyoung-Jin | Korea Adv Inst Sci & Technol, Grad Sch Med Sci & Engn, Daejeon, South Korea; Korea Res Inst Biosci & Biotechnol KRIBB, Metab Regulat Res Ctr, Daejeon, South Korea; Univ Sci & Technol UST, KRIBB Sch Biosci, Dept Funct Genom, Daejeon, South Korea; Korea Res Inst Biosci & Biotechnol KRIBB, Biotherapeut Translat Res Ctr, Daejeon, South Korea; Seoul Natl Univ, Coll Vet Med, Seoul, South Korea; Seoul Natl Univ, Korea Mouse Phenotyping Ctr KMPC, Seoul, South Korea; Korea Univ, Div Life Sci, Seoul, South Korea; Yonsei Univ, Glycosylat Network Res Ctr, Dept Syst Biol, Seoul, South Korea; Korea Res Inst Biosci & Biotechnol KRIBB, Environm Dis Res Ctr, Daejeon, South Korea; Korea Res Inst Biosci & Biotechnol KRIBB, Biodef Res Ctr, Daejeon, South Korea; Yonsei Univ, Dept Surg, Coll Med, Seoul, South Korea; Yonsei Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biochem & Cell Biol, Daegu, South Korea; Korea Res Inst Biosci & Biotechnol KRIBB, Lab Anim Resource Ctr, Daejeon, South Korea; Kangwon Natl Univ, Coll Biomed Sci, Div Biomed Convergence, Chuncheon Si, Gangwon Do, South Korea | Kim, Hail/C-5608-2018; Kim, Young Hoon/F-5424-2012; Hur, Keun/G-9513-2011; Koo, Seung-Hoi/E-2763-2015; Oh, Kyoung-Jin/ADP-6408-2022; Park, Jun Won/KSM-8932-2024; Oh, Kyoung-Jin/AAV-1483-2021; Lee, Chul-Ho/MBV-8603-2025; PARK, JUN-YOUNG/P-5981-2015; Lee, Eun-Woo/AAP-9603-2020; Han, Dai/AAS-3726-2021 | 56764783600; 57202292951; 57208222752; 57205182220; 58096168500; 57226304081; 57190262643; 58095259400; 57213798623; 7406966489; 7401726219; 35331993100; 56424219700; 26424339800; 8861888000; 56223516500; 8056858000; 27171486200; 57049829600; 55661692800; 7004962796; 58096315000; 7410126420; 7102682011; 36741289700 | hailkim@kaist.edu;khbae@kribb.re.kr;kjoh80@kribb.re.kr; | DIABETOLOGIA | DIABETOLOGIA | 0012-186X | 1432-0428 | 66 | 5 | SCIE | ENDOCRINOLOGY & METABOLISM | 2023 | 8.4 | 6.2 | 2.73 | 2025-06-25 | 17 | 17 | Carbohydrate; De novo lipogenesis; Fatty acid; Glucose; Insulin; Lipogenesis; NAFLD; TG accumulation; Type 2 diabetes | PATHWAY EFFECTOR TCF7L2; TRIGLYCERIDE SYNTHESIS; GLUCOSE; HOMEOSTASIS; CHREBP; CELLS; ACIDS; DIFFERENTIATION; EXPRESSION; APOPTOSIS | Carbohydrate; De novo lipogenesis; Fatty acid; Glucose; Insulin; Lipogenesis; NAFLD; TCF7L2; TG accumulation; Type 2 diabetes | Animals; Diabetes Mellitus, Type 2; Diet, High-Fat; Glucose; Hepatocytes; Lipogenesis; Liver; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Transcription Factor 7-Like 2 Protein; Triglycerides; albumin; cre recombinase; glucose; messenger RNA; microRNA; microRNA 33 5p; sterol regulatory element binding protein 1; transcription factor 7 like 2; triacylglycerol; unclassified drug; glucose; Tcf7l2 protein, mouse; transcription factor 7 like 2; triacylglycerol; acute disease; allele; animal experiment; animal model; animal tissue; Article; body composition; C57BL/6N mouse; carbohydrate diet; chow diet; chronic disease; controlled study; de novo lipogenesis; disease exacerbation; exon; fatty liver; gene expression profiling; human; human tissue; in vitro study; in vivo study; insulin sensitivity; knockout mouse; lipid diet; lipid liver level; lipid metabolism; lipogenesis; liver cell; liver histology; liver metabolism; male; metabolic phenotype; mouse; mRNA expression level; nonalcoholic fatty liver; nonalcoholic steatohepatitis; nonhuman; promoter region; protein content; protein expression; refeeding; risk factor; RNA sequencing; animal; C57BL mouse; genetics; lipogenesis; liver; liver cell; metabolism; non insulin dependent diabetes mellitus | English | 2023 | 2023-05 | 10.1007/s00125-023-05878-8 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Vibration signal separation of rotating cylindrical structure through target-less photogrammetric approach | Vibration analysis is one of the most widely used methodologies for structural health monitoring. For vibration monitoring of structures, contact-type sensors, such as gap sensors, are commonly utilized. However, these devices can add mass loading to a lightweight structure, resulting in degradation in performance of the structure. As an alternative, photogrammetric approaches, such as digital image correlation and point-tracking techniques have been proposed for vibration measurement. Despite the many advantages of image-based techniques applied by non-contact-type sensors, these are ineffective in detecting vibrations at the outer edge of a rotating cylinder-shaped structure because tracking of the speckles or targets on the backside of a structure invisible to a camera is impossible. Furthermore, vibrations occurring in structures are usually attributed to multiple factors; to identify these factors individually, the vibration signals should be detected separately. In this study, we introduce a noncontact-based vibration signal separation technique that can be used to recognize multiple factors that cause a structure to vibrate at different frequency rates. For this purpose, the vibration occurring in a structure is first detected using an edge-based vibration measurement technique. A phase-based motion magnification technique is then used to generate multiple magnified videos at different dominant frequencies. Subsequently, vibrations were detected in multiple magnified videos to separate vibration signals. To demonstrate the effectiveness of the proposed method, quantitative and qualitative assess-ments were conducted on both simulation and real video datasets containing vibrations with multiple frequency rates. The results generated by this method can be utilized for health moni-toring of various types of structures on which targets, necessary for the general photogrammetry approach for monitoring purposes, are not attached. Furthermore, the magnified videos generated in this study can be used for the visualization and mode identification of existing vibration signals at different frequencies in a structure. | Javed, Aisha; Park, Jueon; Lee, Hyeongill; Han, Youkyung | Seoul Natl Univ Sci & Technol, Dept Civil Engn, Seoul 01811, South Korea; Kyungpook Natl Univ, Sch Automot Engn, Sangju 37224, South Korea | ; Javed, Aisha/LQK-3075-2024 | 57215897698; 57218222782; 8261483800; 55457676600 | han602@seoultech.ac.kr; | JOURNAL OF SOUND AND VIBRATION | J SOUND VIB | 0022-460X | 1095-8568 | 547 | SCIE | ACOUSTICS;ENGINEERING, MECHANICAL;MECHANICS | 2023 | 4.3 | 6.2 | 0.74 | 2025-06-25 | 4 | 5 | Photogrammetry; Target-less approach; Vibration measurement; Vibration signal separation; Phase-based motion magnification | DIGITAL IMAGE CORRELATION; DAMAGE DETECTION; POINT TRACKING; VISION; MAGNIFICATION; IDENTIFICATION; RESOLUTION; SYSTEM | Phase-based motion magnification; Photogrammetry; Target-less approach; Vibration measurement; Vibration signal separation | Photogrammetry; Structural health monitoring; Vibration analysis; Cylindrical structure; Different frequency; Frequency rate; Multiple factors; Phase based; Phase-based motion magnification; Signal separation; Target-less approach; Vibration signal; Vibration signal separation; Vibration measurement | English | 2023 | 2023-03-17 | 10.1016/j.jsv.2022.117540 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
페이지 이동: