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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | Meeting Abstract | Rationale and study design of the KOV-HIPEC-04: a phase III randomized controlled trial in primary stage three and four ovarian cancer after interval cytoreductive surgery (FOCUS) | Kim, Ji Hyun; Park, Boram; Park, Jeong-Yeol; Lee, Jung-Yun; Chang, Suk-Joon; Lee, Yoo-Young; Hong, Daegy; Cho, Hyun Woong; Ha, Hyeong In; Song, Yong Jung; Kim, Ki Hyung; Park, Sang-Yoon | Natl Canc Ctr, Goyang, South Korea; Samsung Med Ctr, Seoul, South Korea; Asan Med Ctr, Dept Obstet & Gynecol, Seoul, South Korea; Yonsei Univ, Coll Med, Seoul, South Korea; Ajou Univ, Sch Med, Suwon, South Korea; Kyungpook Natl Univ, Med Ctr, Daegu, South Korea; Korea Univ, Coll Med, Seoul, South Korea; Pusan Natl Univ, Yangsan Hosp, Pusan, South Korea; Pusan Natl Univ Hosp, Pusan, South Korea; Natl Canc Ctr, Goyang, South Korea | Lee, Jung-Seok/L-6826-2019 | INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER | INT J GYNECOL CANCER | 1048-891X | 1525-1438 | 34 | SUPPL_1 | SCIE | OBSTETRICS & GYNECOLOGY;ONCOLOGY | 2024 | 4.7 | 5.4 | 0 | English | 2024 | 2024-03 | 10.1136/ijgc-2024-esgo.1103 | 바로가기 | 바로가기 | 바로가기 | |||||||||||||
| ○ | ○ | Article | State observer-based Physics-Informed Machine Learning for leader-following tracking control of mobile robot | In this paper, the novel leader -following tracking control method is proposed for mobile robots, which consists estimation technique of the speed of the leader robot (LR), and a parameter -dependent controller for the follower robot (FR). To estimate the speed of LR, a novel Physics Informed Machine Learning (PIML) is proposed to learn the dynamics of the state observer via the error state model. The dynamics of the state observer in PIML play a significant role for stable learning and state estimation of uncertain models. The gain of the parameter -dependent controller is determined by the convex combination of the robust control technique via the polytopic model. Finally, the tracking performance of the proposed method is verified through the simulation and experiment. | Park, Sejun; Lee, S. M. | Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea | Park, Sejun/KUD-3460-2024; Lee, Sangmoon/C-4502-2018 | 58097901300; 59510733500 | sjpark0710@knu.ac.kr;moony@knu.ac.kr; | ISA TRANSACTIONS | ISA T | 0019-0578 | 1879-2022 | 146 | SCIE | AUTOMATION & CONTROL SYSTEMS;ENGINEERING, MULTIDISCIPLINARY;INSTRUMENTS & INSTRUMENTATION | 2024 | 6.5 | 5.4 | 0.43 | 2025-05-07 | 0 | 1 | Physics-Informed Machine Learning (PIML); State observer; Time-varying parameter estimation; System identification; Leader-following tracking control | Leader-following tracking control; Physics-Informed Machine Learning (PIML); State observer; System identification; Time-varying parameter estimation | Controllers; Mobile robots; Navigation; Parameter estimation; Robust control; State estimation; Time varying control systems; Leader following; Leader robots; Leader-following tracking control; Machine-learning; Parameter-dependent controllers; Physic-informed machine learning; States observer; System-identification; Time-varying parameter estimation; Tracking controls; animal experiment; article; controlled study; eye tracking; leadership; learning; machine learning; simulation; velocity; Machine learning | English | 2024 | 2024-03 | 10.1016/j.isatra.2024.01.001 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Whole-Body Muscle Magnetic Resonance Imaging in 81 Patients with Spinal and Bulbar Muscular Atrophy: A Prospective Study | Objective: Spinal and bulbar muscular atrophy (SBMA) is characterized by slow, progressive bulbar and limb muscle weakness; however, the pattern of progression of muscle fat infiltration remains unclear. We assessed the progression of muscle involvement in 81 patients with SBMA using whole-body muscle magnetic resonance imaging (MRI), alongside clinical and laboratory findings.Methods: This prospective study included patients with genetically confirmed SBMA who underwent whole-body muscle MRI. We analyzed muscle fat infiltration and the pattern of involved muscles using cluster analysis, visualizing the sequential progression of fat infiltration. Muscle clusters demonstrated correlation with clinical scales and laboratory findings. Additionally, linear regression analysis was performed to identify the MRI section most strongly associated with 6-minute walk test (6MWT).Results: We included 81 patients with SBMA (age = 54.3 years). After categorizing the patients into 6 clusters based on the pattern of muscle fat infiltration, we observed that muscle involvement began in the posterior calf and progressed to the posterior thigh, pelvis, trunk, anterior thigh, medial thigh, anterior calf, and upper extremity muscles. These muscle clusters correlated significantly with disease duration (tau = 0.47, p < 0.001), 6MWT (tau = -0.49, p < 0.001), and serum creatinine level (tau = -0.46, p < 0.001). The whole-body MRI indicated the thigh as the section most significantly correlated with 6MWT.Interpretation: We used whole-body muscle MRI to determine the sequential progression of the fat infiltration in SBMA. Our findings may enable the identification of objective and reliable imaging outcome measures in the study of the natural history or future clinical trials of SBMA. ANN NEUROL 2023 | Kim, Hyunjin; Seo, Incheol; Kang, Minsung; Park, Jin-Mo; Seok, Hung Youl; Kim, Sohyeon; Park, Jin-Sung | Univ Ulsan, Coll Med, Asan Med Ctr, Dept Neurol, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Immunol, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Neurol, Daegu, South Korea; Dongguk Univ, Gyeongju Hosp, Dept Neurol, Coll Med, Gyeongju, South Korea; Keimyung Univ, Sch Med, Dongsan Hosp, Dept Neurol, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Neurol, Daegu, South Korea; Korea Brain Res Inst, Dementia Res Grp, Daegu, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu, South Korea | Seok, Hung Youl/HZI-4365-2023; Kim, Hyunjin/MDS-5282-2025 | 57843819900; 56022683900; 57719257600; 55569003000; 24472118000; 57214724357; 44061744500 | neurojspark@gmail.com; | ANNALS OF NEUROLOGY | ANN NEUROL | 0364-5134 | 1531-8249 | 95 | 3 | SCIE | CLINICAL NEUROLOGY;NEUROSCIENCES | 2024 | 7.7 | 5.4 | 0.62 | 2025-05-07 | 0 | 1 | ANDROGEN RECEPTOR GENE; CREATINE-KINASE; MANIFESTATIONS; FEATURES; MRI | Bulbo-Spinal Atrophy, X-Linked; Humans; Magnetic Resonance Imaging; Middle Aged; Muscle, Skeletal; Muscular Atrophy; Muscular Atrophy, Spinal; Prospective Studies; creatinine; adult; aged; arm muscle; Article; capillary electrophoresis; controlled study; creatinine blood level; disease duration; female; forced vital capacity; genetic analysis; human; Kennedy disease; latissimus dorsi muscle; major clinical study; male; nuclear magnetic resonance imaging; polymerase chain reaction; prospective study; six minute walk test; supine position; thigh muscle; tibialis anterior muscle; triceps surae muscle; whole body MRI; diagnostic imaging; Kennedy disease; middle aged; muscle atrophy; nuclear magnetic resonance imaging; pathology; prospective study; skeletal muscle; spinal muscular atrophy | English | 2024 | 2024-03 | 10.1002/ana.26846 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Effect of solid obstacle and thermal conditions on convective flow and entropy generation of nanofluid filled in a cylindrical chamber | PurposeOne of the major challenges in the design of thermal equipment is to minimize the entropy production and enhance the thermal dissipation rate for improving energy efficiency of the devices. In several industrial applications, the structure of thermal device is cylindrical shape. In this regard, this paper aims to explore the impact of isothermal cylindrical solid block on nanofluid (Ag - H2O) convective flow and entropy generation in a cylindrical annular chamber subjected to different thermal conditions. Furthermore, the present study also addresses the structural impact of cylindrical solid block placed at the center of annular domain.Design/methodology/approachThe alternating direction implicit and successive over relaxation techniques are used in the current investigation to solve the coupled partial differential equations. Furthermore, estimation of average Nusselt number and total entropy generation involves integration and is achieved by Simpson and Trapezoidal's rules, respectively. Mesh independence checks have been carried out to ensure the accuracy of numerical results.FindingsComputations have been performed to analyze the simultaneous multiple influences, such as different thermal conditions, size and aspect ratio of the hot obstacle, Rayleigh number and nanoparticle shape on buoyancy-driven nanoliquid movement, heat dissipation, irreversibility distribution, cup-mixing temperature and performance evaluation criteria in an annular chamber. The computational results reveal that the nanoparticle shape and obstacle size produce conducive situation for increasing system's thermal efficiency. Furthermore, utilization of nonspherical shaped nanoparticles enhances the heat transfer rate with minimum entropy generation in the enclosure. Also, greater performance evaluation criteria has been noticed for larger obstacle for both uniform and nonuniform heating.Research limitations/implicationsThe current numerical investigation can be extended to further explore the thermal performance with different positions of solid obstacle, inclination angles, by applying Lorentz force, internal heat generation and so on numerically or experimentally.Originality/valueA pioneering numerical investigation on the structural influence of hot solid block on the convective nanofluid flow, energy transport and entropy production in an annular space has been analyzed. The results in the present study are novel, related to various modern industrial applications. These results could be used as a firsthand information for the design engineers to obtain highly efficient thermal systems. | Swamy, H. A. Kumara; Mani, Sankar; Reddy, N. Keerthi; Do, Younghae | Kyungpook Natl Univ, Dept Math, Nonlinear Dynam & Math Applicat Ctr, Daegu, South Korea; Univ Technol & Appl Sci Ibri, Dept Informat Technol, Ibri, Oman; Presidency Univ, Dept Math, Bangalore, India; Presidency Univ, Dept Math, Bangalore, India; Ulsan Natl Inst Sci & Technol, Dept Mech Engn, Ulsan, South Korea | Reddy N., Keerthi/AAT-5305-2021; , KEERTHI REDDY N/AAT-5305-2021; Do, Younghae/G-3522-2011; Swamy, H.A. Kumara/AAT-5304-2021 | 57223027638; 58662607100; 57218368327; 7103101109 | yhdo@knu.ac.kr; | INTERNATIONAL JOURNAL OF NUMERICAL METHODS FOR HEAT & FLUID FLOW | INT J NUMER METHOD H | 0961-5539 | 1758-6585 | 34 | 1 | SCIE | MATHEMATICS, INTERDISCIPLINARY APPLICATIONS;MECHANICS;THERMODYNAMICS | 2024 | 5.1 | 5.5 | 0.45 | 2025-05-07 | 1 | 1 | Annular chamber; Buoyant convection; Cup-mixing temperature; Entropy generation; Hot obstacle; Nanoparticle shape | NATURAL-CONVECTION; SQUARE ENCLOSURE; HEAT-TRANSFER; CIRCULAR-CYLINDER; MAGNETIC-FIELD; CAVITY; BODY | Annular chamber; Buoyant convection; Cup-mixing temperature; Entropy generation; Hot obstacle; Nanoparticle shape | Buoyancy; Energy efficiency; Entropy; Heat convection; Mixing; Nanofluidics; Nanoparticles; Annular chamber; Buoyant convection; Cup-mixing temperature; Entropy generation; Hot obstacle; Mixing temperature; Nanoparticle shape; Solid blocks; Solid obstacles; Thermal condition; Aspect ratio | English | 2024 | 2024-01-02 | 10.1108/hff-08-2023-0466 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Numerical investigation of nanofluid buoyant flow behavior and heat transfer characteristics in annular-shaped enclosure with internal baffle | PurposeNatural convection in finite enclosures is a common phenomenon in various thermal applications. To provide the thermal design guidelines, this study aims to numerically explore the potential of using internal baffles and nanofluids to either enhance or suppress heat transport in a vertical annulus. Furthermore, the annular-shaped enclosure is filled with aqueous-silver nanofluid and the effects of five distinct nanoparticle shapes are examined. In addition, the influence of baffle design parameters, including baffle position, thickness and length, is thoroughly analyzed.Design/methodology/approachThe finite difference method is used in conjunction with the alternating direction implicit and successive line over relaxation techniques to solve nonlinear and coupled partial differential equations. The single phase model is used for nanofluid which is considered as a homogeneous fluid with improved thermal properties. The independence tests are carried out for assessing the sufficiency of grid size and time step for obtaining results accurately.FindingsThe baffle dimension parameters and nanoparticle shape exhibit significant impact on the convective flow and heat transfer characteristics, leading to the following results: sphere- and blade-shaped nanoparticles demonstrate around 30% enhancement in the heat transport capability compared with platelet-shaped nanoparticles, which exhibit the least. When considering the baffle design parameter, either a decrease in the baffle length and thickness or an increase in baffle height leads to an improvement in heat transport rate. Consequently, a threefold increase in baffle height yields a 40% improvement in thermal performance.Originality/valueUnderstanding the impact of nanoparticle shapes and baffle design parameters on flow and thermal behavior will enable engineers to provide valuable insight on thermal management and overall system efficiency. Therefore, the current work focuses on exploring buoyant nanofluid flow and thermal mechanism in a baffled annular-shaped enclosure. Specifically, an internal baffle that exhibits conductive heat transfer through it is considered, and the impact of baffle dimensions (thickness, length and position) on the fluid flow behavior and thermal characteristics is investigated. In addition, the current study also addresses the influence of five distinct nanoparticle shapes (e.g. spherical, cylindrical, platelet, blade and brick) on the flow and thermal behavior in the baffled annular geometry. In addition to deepening the understanding of nanofluid behavior in a baffled vertical annulus, the current study contributes to the ongoing advancements in thermal applications by providing certain guidelines to design application-specific enclosures. | Reddy, N. Keerthi; Yoon, Aejung; Mani, Sankar; Swamy, H. A. Kumara | Ulsan Natl Inst Sci & Technol, Dept Mech Engn, Ulsan, South Korea; Univ Technol & Appl Sci Ibri, Dept Math, Ibri, Oman; Presidency Univ, Dept Math, Bangalore, India; Kyungpook Natl Univ, Nonlinear Dynam & Math Applicat Ctr, Dept Math, Daegu, South Korea | , KEERTHI REDDY N/AAT-5305-2021; Reddy N., Keerthi/AAT-5305-2021; Swamy, H.A. Kumara/AAT-5304-2021 | 57218368327; 57193253138; 58662607100; 57223027638 | ajyoon@unist.ac.kr; | INTERNATIONAL JOURNAL OF NUMERICAL METHODS FOR HEAT & FLUID FLOW | INT J NUMER METHOD H | 0961-5539 | 1758-6585 | 34 | 1 | SCIE | MATHEMATICS, INTERDISCIPLINARY APPLICATIONS;MECHANICS;THERMODYNAMICS | 2024 | 5.1 | 5.5 | 1.79 | 2025-05-07 | 6 | 4 | Nanofluid; Natural convection; Nanoparticle shape; Annular-shaped enclosure; Internal baffle design | LAMINAR NATURAL-CONVECTION; THERMAL BARRIER COATINGS; CU-WATER NANOFLUID; SQUARE CAVITY; MIXED CONVECTION; THIN FIN; TRANSFER ENHANCEMENT; ENTROPY GENERATION; MAGNETIC-FIELD; PARTITION | Annular-shaped enclosure; Internal baffle design; Nanofluid; Nanoparticle shape; Natural convection | Buoyancy; Enclosures; Finite difference method; Flow of fluids; Nanofluidics; Nanoparticles; Nonlinear equations; Platelets; 'current; Annular-shaped enclosure; Design parameters; Flow behaviours; Heat transport; Heat-transfer characteristics; Internal baffle design; Nanofluids; Nanoparticle shape; Thermal applications; Natural convection | English | 2024 | 2024-01-02 | 10.1108/hff-09-2023-0524 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Age- and ethnic-driven molecular and clinical disparity of East Asian breast cancers | BackgroundBreast cancer (BC) is a complex disease with profound genomic aberrations. However, the underlying molecular disparity influenced by age and ethnicity remains elusive.MethodsIn this study, we aimed to investigate the molecular properties of 843 primary and metastatic BC patients enrolled in the K-MASTER program. By categorizing patients into two distinct age subgroups, we explored their unique molecular properties. Additionally, we leveraged large-scale genomic data from the TCGA and MSK-IMPACT studies to examine the ethnic-driven molecular and clinical disparities.ResultsWe observed a high prevalence of PI3KCA mutations in K-MASTER HER2 + tumors, particularly in older patients. Moreover, we identified increased mutation rates in DNA damage response molecules, including ARID1A, MSH6, and MLH1. The K-MASTER patients were mainly comprised of triple-negative breast cancer (TNBC) and HER2-positive tumors, while the TCGA and MSK-IMPACT cohorts exhibited a predominance of hormone receptor-positive (HR +) subtype tumors. Importantly, GATA3 mutations were less frequently observed in East Asian patients, which correlated with poor clinical outcomes. In addition to characterizing the molecular disparities, we developed a gradient-boosting multivariable model to identify a new molecular signature that could predict the therapeutic response to platinum-based chemotherapy.ConclusionsOur findings collectively provide unprecedented insights into the significance of age and ethnicity on the molecular and clinical characteristics of BC patients. | Lee, Ji Yoon; Lee, Ji Won; Chung, Min Sung; Choi, Jong Gwon; Sim, Sung Hoon; Kim, Hyo Jeong; Kim, Jeong Eun; Lee, Kyoung Eun; Park, Yeon Hee; Kang, Myoung Joo; Ahn, Mi Sun; Chae, Yee Soo; Park, Ji Hyun; Kim, Jee Hyun; Kim, Gun Min; Byun, Jae Ho; Park, Keon Uk; Kim, Ju Won; Jung, Seung Pil; Lee, Jung Hyun; An, Jung Seok; Jang, Byunghyun; Yoon, Dayoung; Kim, Jiwon; Hong, Jisoo; Koo, Harim; Cho, Kyu Ran; Kim, Cheol Yong; Sa, Jason K.; Park, Kyong Hwa | Korea Univ, Dept Biomed Informat, Coll Med, Seoul, South Korea; Korea Univ, Coll Med, Dept Biomed Sci, Seoul, South Korea; Korea Univ, Anam Hosp, Dept Internal Med, Div Med Oncol, Seoul, South Korea; Hanyang Univ, Coll Med, Dept Surg, Seoul 04763, South Korea; Konyang Univ Hosp, Dept Oncol Hematol, Daejeon, South Korea; Natl Canc Ctr, Ctr Breast Canc, Goyang, South Korea; Pusan Natl Univ Hosp, Med Res Inst, Dept Internal Med, Div Hematol Oncol,Sch Med, Pusan, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Oncol, Seoul, South Korea; Ewha Womans Univ Hosp, Dept Hematol & Oncol, Mokdong Hosp, Seoul 07985, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Seoul, South Korea; Inje Univ, Haeundae Paik Hosp, Dept Internal Med, Busan, South Korea; Ajou Univ, Sch Med, Dept Hematol Oncol, Suwon, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Hematol & Oncol, Daegu, South Korea; KonKuk Univ, Dept Hematol Oncol, Div Internal Med, Med Ctr, Seoul, South Korea; Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Div Hematol & Med Oncol, 166 Gumi Ro, Songnam 463707, South Korea; Yonsei Univ, Coll Med, Dept Internal Med, Div Med Oncol, 50-1 Yonsei Ro, Seoul 120752, South Korea; Catholic Univ Korea, Incheon St Marys Hosp, Coll Med, Dept Internal Med,Div Oncol, Seoul, South Korea; Keimyung Univ, Coll Med, Dept Internal Med, Div Hematol Oncol,Dongsan Hosp, Daegu, South Korea; Korea Univ, Anam Hosp, Dept Surg, Div Breast Endocrine Surg,Dept Breast Surg, Seoul, South Korea; Korea Univ, Anam Hosp, Dept Pathol, Seoul, South Korea; Korea Univ, KU KIST Grad Sch Converging Sci & Technol, Seoul, South Korea; Natl Canc Ctr, Grad Sch Canc Sci & Policy, Dept Canc Biomed Sci, Goyang, South Korea; Korea Univ, Anam Hosp, Dept Radiol, Seoul, South Korea | ; Park, Eun/W-1340-2019; KANG, MIN KYU/ACI-8824-2022; Lee, Jiwon/KIB-9488-2024 | 8086802200; 58101006100; 25635235100; 7501392200; 25926764600; 57200111630; 57218595065; 7501517217; 35273175600; 57190689321; 35885237100; 57190793908; 57129240900; 56004266300; 24483766500; 57209110516; 55898683500; 58506497500; 55645078600; 56158225400; 14017842000; 57575094600; 57575066500; 59640829000; 58910250300; 57205687195; 7403957231; 57773496100; 56803454400; 7408065807 | jasonksa@korea.ac.kr;khpark@korea.ac.kr; | BMC MEDICINE | BMC MED | 1741-7015 | 22 | 1 | SCIE | MEDICINE, GENERAL & INTERNAL | 2024 | 8.3 | 5.6 | 0 | 2025-05-07 | 0 | 1 | Breast cancer; Ethnic diversity; Genomic alterations; Molecular subtypes; Precision medicine | GENOMIC LANDSCAPE; PORTRAITS; EVOLUTION; PATTERNS; FEATURES; THERAPY | Breast cancer; Ethnic diversity; Genomic alterations; Molecular subtypes; Precision medicine | Adult; Age Factors; Aged; Aged, 80 and over; Asian People; Breast Neoplasms; Class I Phosphatidylinositol 3-Kinases; East Asian People; Female; GATA3 Transcription Factor; Humans; Middle Aged; Mutation; Receptor, ErbB-2; BRCA2 protein; epidermal growth factor receptor 2; phosphatidylinositol 3 kinase; platinum; protein p53; transcription factor GATA 3; transcription factor RUNX1; epidermal growth factor receptor 2; ERBB2 protein, human; GATA3 protein, human; phosphatidylinositol 4,5 bisphosphate 3 kinase; transcription factor GATA 3; adult; Article; bioinformatics; breast cancer; cancer prognosis; cancer survival; copy number variation; DNA damage; female; gene mutation; health disparity; heterozygosity; high throughput sequencing; human; liver metastasis; lymph node metastasis; major clinical study; mismatch repair; mutational analysis; overall survival; personalized medicine; progression free survival; single nucleotide polymorphism; somatic mutation; triple negative breast cancer; tumor growth; tumor suppressor gene; whole exome sequencing; age; aged; Asian; breast tumor; East Asian; genetics; middle aged; mutation; very elderly | English | 2024 | 2024-09-27 | 10.1186/s12916-024-03638-y | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Combination of red ginseng and velvet antler extracts prevents skin damage by enhancing the antioxidant defense system and inhibiting MAPK/AP-1/ NF-KB and caspase signaling pathways in UVB-irradiated HaCaT keratinocytes and SKH-1 hairless mice | Background: Studies have reported that the combination of two or more therapeutic compounds at certain ratios has more noticeable pharmaceutical properties than single compounds and requires reduced dosage of each agent. Red ginseng and velvet antler have been extensively used in boosting immunity and physical strength and preventing diseases. Thus, this study was conducted to elucidate the skin-protective potentials of red ginseng extract (RGE) and velvet antler extract (VAE) alone or in combination on ultraviolet (UVB)-irradiated human keratinocytes and SKH-1 hairless mice. Methods: HaCaT cells were preincubated with RGE/VAE alone or in combination for 2 h before UVB (30 mJ/cm2) irradiation. SKH-1 mice were orally given RGE/VAE alone or in combination for 15 days before exposure to single dose of UVB (600 mJ/cm2). Treated cells and treated skin tissues were collected and subjected to subsequent experiments. Results: RGE/VAE pretreatment alone or in combination significantly prevented UVB-induced cell death, apoptosis, reactive oxygen species production, and DNA damage in keratinocytes and SKH-1 mouse skins by downregulating mitogen-activated protein kinases/activator protein 1/nuclear factor kappa B and caspase signaling pathways. These extracts also strengthened the antioxidant defense systems and skin barriers in UVBirradiated HaCaT cells and SKH-1 mouse skins. Furthermore, RGE/VAE co-administration appeared to be more effective in preventing UVB-caused skin injury than these extracts used alone. Conclusion: Overall, these findings suggest that the consumption of RGE/VAE, especially in combination, offers a protective ability against UVB-caused skin injury by preventing inflammation and apoptosis and enhancing antioxidant capacity. | Truong, Van-Long; Bae, Yeon-Ji; Bang, Ji-Hong; Jeong, Woo-Sik | Kyungpook Natl Univ, Food & Bioind Res Inst, Coll Agr & Life Sci, Sch Food Sci Biotechnol, Daegu 41566, South Korea | Jeong, Woo-Sik/AAN-6885-2020 | 55925363400; 58150149400; 58150149300; 10440750200 | wsjeong@knu.ac.kr; | JOURNAL OF GINSENG RESEARCH | J GINSENG RES | 1226-8453 | 2093-4947 | 48 | 3 | SCIE | CHEMISTRY, MEDICINAL;INTEGRATIVE & COMPLEMENTARY MEDICINE | 2024 | 5.6 | 5.6 | 4.1 | 2025-05-07 | 7 | 8 | Red ginseng extract; Velvet antler extract; Skin protection; UVB radiation | INDUCED OXIDATIVE DAMAGE; KAPPA-B; INFLAMMATION; COMPONENTS; GROWTH; PANAX; CELLS; ROLES; DEATH; AP-1 | Red ginseng extract; Skin protection; UVB radiation; Velvet antler extract | antioxidant; ascorbic acid; caspase; ginseng extract; immunoglobulin enhancer binding protein; mitogen activated protein kinase; plant extract; reactive oxygen metabolite; skin protective agent; transcription factor AP 1; unclassified drug; velvet antler extract; animal experiment; animal model; antler; apoptosis; Article; cell death; controlled study; DNA damage; female; ginseng; HaCat cell line; keratinocyte; mouse; nonhuman; signal transduction; skin defect; skin protection; ultraviolet B radiation | English | 2024 | 2024-05 | 10.1016/j.jgr.2024.01.003 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Development of human amniotic epithelial cell-derived extracellular vesicles as cell-free therapy for dry eye disease | Purpose This study aimed to investigate the therapeutic potential of extracellular vesicles (EVs) derived from human amniotic epithelial cells (hAEC-EVs) for Dry Eye Disease (DED) treatment. Methods Highly purified EVs were isolated from the culture supernatants of hAECs, which obtained from term placenta and characterized. Proteomic contents were analyzed for assessing its biological function related to the therapeutic potentials for DED. Subsequently, we examined the therapeutic efficacy of hAEC-EVs on human corneal epithelial cells exposed to hyperosmotic stress and in an experimental DED mouse model induced by desiccation stress. Results Proteomic analysis of hAEC-EVs revealed proteins linked to cell proliferation and anti-inflammatory responses. We demonstrated efficient uptake of hAEC-EVs by ocular surface cells. Under DED conditions, EV treatment increased corneal epithelial cell proliferation and migration, and concurrently reducing inflammatory cytokines. In the DED mouse model, hAEC-EVs showed significant improvements in corneal staining score, tear secretion, corneal irregularity, and conjunctival goblet cell density. Additionally, hAEC-EVs exhibited a mitigating effect on ocular surface inflammation induced by desiccation. Conclusions These findings suggest that hAEC-EVs hold potential as a cell-free therapy for corneal epithelial defects and ocular surface diseases, presenting a promising treatment option for DED. | Yi, Soojin; Kim, Jeongho; Kim, Mi Ju; Yae, Che Gyem; Kim, Ki Hean; Kim, Hong Kyun | Kyungpook Natl Univ, Sch Med, Dept Ophthalmol, Daegu, South Korea; Kyungpook Natl Univ Hosp, Biomed Inst, Daegu, South Korea; Kyungpook Natl Univ, Grad Sch, Dept Biomed Sci, Daegu, South Korea; Pohang Univ Sci & Technol, Dept Mech Engn, Pohang, Gyeongbuk, South Korea; Kyungpook Natl Univ, Sch Med, Dept Obstet & Gynecol, Daegu, South Korea | Kim, Mi Ju/HGU-8470-2022; Kim, Hong Kyun/ITT-7758-2023 | 56783537100; 57219385573; 55908927600; 56048982200; 57416795300; 57218260940 | kiheankim@postech.ac.kr;okeye@knu.ac.kr; | OCULAR SURFACE | OCUL SURF | 1542-0124 | 1937-5913 | 34 | SCIE | OPHTHALMOLOGY | 2024 | 5.6 | 5.6 | 2.89 | 2025-05-07 | 4 | 4 | Dry eye disease; Amniotic membrane; Amniotic epithelial cells; Extracellular vesicles | MESENCHYMAL STEM-CELLS; EXOSOMES; SUPERNATANT; ROLES | Amniotic epithelial cells; Amniotic membrane; Dry eye disease; Extracellular vesicles | Amnion; Animals; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Dry Eye Syndromes; Epithelial Cells; Epithelium, Corneal; Extracellular Vesicles; Female; Humans; Mice; Proteomics; beta1 integrin; cadherin; CD9 antigen; cell adhesion molecule; epidermal growth factor receptor; gamma interferon; granulocyte macrophage colony stimulating factor; interleukin 1alpha; interleukin 1beta; interleukin 6; interleukin 8; monocyte chemotactic protein 1; scleroprotein; scopolamine; tumor necrosis factor; Wnt protein; amnion cell; animal experiment; animal model; antiinflammatory activity; Article; bioinformatics; cell adhesion; cell growth; cell migration; cell proliferation; cesarean section; cornea epithelium; cornea tissue; cytokine signaling; density; desiccation; differential expression analysis; dry eye syndrome; epithelium cell; epithelium lesion; exosome; gene ontology; goblet cell; human; human cell; human tissue; hyperosmotic stress; in vitro study; in vivo study; inflammation; KEGG; lacrimation; male; morphology; mouse; nonhuman; ocular surface cell; ocular surface disease; placenta; protein analysis; protein binding; protein expression; protein localization; proteomics; purification; slit lamp microscopy; stem cell transplantation; supernatant; topical treatment; Wnt signaling; amnion; animal; cell culture; cytology; disease model; dry eye syndrome; female; metabolism; procedures; therapy; transplantation | English | 2024 | 2024-10 | 10.1016/j.jtos.2024.09.006 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Evaluation of bovine coronavirus in Korean native calves challenged through different inoculation routes | Bovine coronavirus (BCoV) is a pneumoenteric virus that can infect the digestive and respiratory tracts of cattle, resulting in economic losses. Despite its significance, information regarding BCoV pathogenesis is limited. Hence, we investigated clinical signs, patterns of viral shedding, changes in antibody abundance, and cytokine/chemokine production in calves inoculated with BCoV via intranasal and oral. Six clinically healthy Korean native calves (< 30 days old), initially negative for BCoV, were divided into intranasal and oral groups and monitored for 15 days post-infection (dpi). BCoV-infected calves exhibited clinical signs such as nasal discharge and diarrhea, starting at 3 dpi and recovering by 12 dpi, with nasal discharge being the most common symptoms. Viral RNA was detected in nasal and fecal samples from all infected calves. Nasal shedding occurred before fecal shedding regardless of the inoculation route; however, fecal shedding persisted longer. Although the number of partitions was very few, viral RNA was identified in the blood of two calves in the oral group at 7 dpi and 9 dpi using digital RT-PCR analysis. The effectiveness of maternal antibodies in preventing viral replication and shedding appeared limited. Our results showed interleukin (IL)-8 as the most common and highly induced chemokine. During BCoV infection, the levels of IL-8, monocyte chemoattractant protein-1, and macrophage inflammatory protein-1 beta were significantly affected, suggesting that these emerge as potential and reliable biomarkers for predicting BCoV infection. This study underscores the importance of BCoV as a major pathogen causing diarrhea and respiratory disease. | Cho, Hyung-Chul; Kim, Youngjun; Cho, Yong-Il; Park, Jinho; Choi, Kyoung-Seong | Kyungpook Natl Univ, Coll Ecol & Environm Sci, Dept Anim Sci & Biotechnol, Sangju 37224, South Korea; Jeonbuk Univ, Coll Vet Med, Dept Vet Internal Med, Iksan 54596, South Korea; Hanwoo Korean indigenous cattle Genet Improvement, Dept Anim Hosp, Natl Agr Cooperat Federat, Seosan 31948, South Korea; Sunchon Natl Univ, Coll Bioind Sci, Dept Anim Sci & Technol, Sunchon 57922, South Korea | 57219427000; 58845436500; 55196062700; 8730126700; 7403949556 | jpark@jbnu.ac.kr;kschoi3@knu.ac.kr; | VETERINARY RESEARCH | VET RES | 0928-4249 | 1297-9716 | 55 | 1 | SCIE | VETERINARY SCIENCES | 2024 | 3.5 | 5.6 | 2.51 | 2025-05-07 | 3 | 3 | Bovine coronavirus; inoculation route; nasal discharge; virus shedding; interleukin-8 | CALF DIARRHEA; RESPIRATORY-DISEASE; CANINE CORONAVIRUS; BEEF-CALVES; RT-PCR; INFECTION; SUSCEPTIBILITY; PATHOGENESIS; ROTAVIRUS; CYTOKINES | Bovine coronavirus; inoculation route; interleukin-8; nasal discharge; virus shedding | Animals; Antibodies, Viral; Cattle; Cattle Diseases; Coronavirus Infections; Coronavirus, Bovine; Cytokines; Feces; Male; Republic of Korea; RNA, Viral; Virus Shedding; cytokine; virus antibody; virus RNA; animal; blood; bovine; Bovine coronavirus; cattle disease; Coronavirus infection; feces; genetics; immunology; male; metabolism; South Korea; veterinary medicine; virology; virus shedding | English | 2024 | 2024-06-11 | 10.1186/s13567-024-01331-9 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Correction | Korean red ginseng extract ameliorates melanogenesis in humans and induces anti-photo aging effects in ultraviolet B-irradiated hairless mice (vol 44, pg 496, 2020) | Saba, Evelyn; Kim, Seung-Hyung; Lee, Yuan Yee; Park, Chae-Kyu; Oh, Jae-Wook; Kim, Tae-Hwan; Kim, Hyun-Kyoung; Roh, Seong-Soo; Rhee, Man Hee | Kyungpook Natl Univ, Lab Physiol & Cell Signalling, Daegu, South Korea; Daejeon Univ, Inst Tradit Med & Biosci, Daejeon, South Korea; Korean Ginseng Cooperat, R&D Headquarters, Daejeon, South Korea; Konkuk Univ, Dept Stem Cell & Regenerat Biotechnol, Seoul, South Korea; Seowon Univ, Dept Food Sci & Engn, Chungbuk, South Korea; Daegu Haany Univ, Coll Korean Med, 64 Gil,25 Suseongro, Daegu 42158, South Korea | Kim, Seung-Hyung/AAA-4707-2020; Oh, Jae-Wook/D-3597-2011; Rhee, Man/O-5705-2016; Kim, Hyun-Kyoung/AGY-2204-2022; Yuan Yee, Lee/ABH-8956-2022; Saba, Evelyn/JLN-1878-2023 | 56721112000; 54383305300; 57203798815; 55885553100; 34875481900; 57202984578; 55791359100; 12752302700; 57211035357 | ddede@dhu.ac.kr;rheemh@knu.ac.kr; | JOURNAL OF GINSENG RESEARCH | J GINSENG RES | 1226-8453 | 2093-4947 | 48 | 4 | SCIE | CHEMISTRY, MEDICINAL;INTEGRATIVE & COMPLEMENTARY MEDICINE | 2024 | 5.6 | 5.6 | 0 | 2025-05-07 | 0 | 0 | ginseng extract; clinical article; erratum; female; ginseng; hairless mouse; human; irradiation; melanogenesis; Panax; photoaging; ultraviolet B radiation | English | 2024 | 2024-07 | 10.1016/j.jgr.2024.05.005 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Red ginseng extract inhibits lipopolysaccharide-induced platelet-leukocyte aggregates in mice | Background: Platelet-leukocyte aggregates (PLAs) play important roles in cardiovascular disease and sepsis. Red ginseng extract (RGE) has been well-studied for its antiplatelet and anti-inflammatory activities. However, the potential inhibitory effects of RGE on PLA have not been investigated. Methods: Six-week-old ICR mice were given oral gavage of RGE for 7 days, followed by an intraperitoneal injection of 15 mg/kg of lipopolysaccharide. Mice were euthanized 24 h later, and blood samples were collected for further analysis. Flow cytometry was utilized to sort populations of PLAs and platelet-neutrophil aggregates (PNAs). By using confocal microscopy, PNAs were validated. Morphological changes in platelets and leukocytes were visualized with scanning electron microscopy. Expressions of tissue factor (TF) and platelet factor 4 (PF4) were investigated using enzyme-linked immunosorbent assay. Results: Populations of activated platelets, PLAs and PNAs, were significantly increased with LPS-induction. Treatment with 200 and 400 mg/kg of RGE decreased platelet activation. Moreover, the populations of PLAs and PNAs were reduced. PNAs were visible in the blood of septic mice, and this was attenuated by treatment with 400 mg/kg of RGE. Morphologically, sepsisinduced platelet activation and fibrin formation in the blood. This was reduced with RGE treatment. Sepsis-induced increase in the plasma levels of TF and PF4 was also reduced with RGE treatment. Conclusion: This study shows that RGE is a potential therapeutic that reduces the activation of platelets and targets PLA and PNA formation. Detailed inhibitory mechanisms of RGE should be studied. | Lee, Yuan Yee; Kim, Sung Dae; Park, Jin-Kyu; Lee, Won-Jae; Han, Jee Eun; Seo, Min-Soo; Seo, Min-Goo; Bae, Seulgi; Kwak, Dongmi; Saba, Evelyn; Rhee, Man Hee | Kyungpook Natl Univ, Dept Vet Med, Daegu, South Korea; Univ Maryland, Dept Anim & Avian Sci, College Pk, MD USA; Pir Mehr Ali Shah Arid Agr Univ, Fac Vet & Anim Sci, Dept Vet Biomed Sci, Rawalpindi, Pakistan; Kyungpook Natl Univ, Inst Vet Biomed Sci, Coll Vet Med, Daegu, South Korea; Kyungpook Natl Univ, Coll Vet Med, Lab Physiol & Cell Signaling, Daegu 41566, South Korea | Saba, Evelyn/JLN-1878-2023; Seo, Min-Goo/NQF-4335-2025; Yuan Yee, Lee/ABH-8956-2022; Rhee, Man/O-5705-2016 | 57203798815; 55156746000; 35213723500; 57205486455; 57214671240; 35254332100; 53982155300; 55418865900; 7007148758; 56721112000; 57211035357 | rheemh@knu.ac.kr; | JOURNAL OF GINSENG RESEARCH | J GINSENG RES | 1226-8453 | 2093-4947 | 48 | 4 | SCIE | CHEMISTRY, MEDICINAL;INTEGRATIVE & COMPLEMENTARY MEDICINE | 2024 | 5.6 | 5.6 | 0.59 | 2025-05-07 | 1 | 1 | Platelet activation; Platelet-leukocyte aggregates; Red ginseng extract; Inflammation; Thrombosis | SAPONIN FRACTION; SEPSIS; MECHANISMS; MICROPARTICLES; ACTIVATION; THROMBOSIS | Inflammation; Platelet activation; Platelet–leukocyte aggregates; Red ginseng extract; Thrombosis | dexamethasone; ginseng extract; lipopolysaccharide; thrombocyte factor 4; thromboplastin; animal experiment; animal model; animal tissue; antiinflammatory activity; antiplatelet activity; Article; blood sampling; confocal microscopy; controlled study; enzyme linked immunosorbent assay; fibrin formation; flow cytometry; ginseng; immunofluorescence; leukocyte; lymphocyte function; mouse; nonhuman; scanning electron microscopy; sepsis; thrombocyte; thrombocyte activation | English | 2024 | 2024-07 | 10.1016/j.jgr.2024.03.009 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Systematic exploration of therapeutic effects and key mechanisms of Panax ginseng using network-based approaches | Background: Network pharmacology has emerged as a powerful tool to understand the therapeutic effects and mechanisms of natural products. However, there is a lack of comprehensive evaluations of network-based approaches for natural products on identifying therapeutic effects and key mechanisms. Purpose: We systematically explore the capabilities of network-based approaches on natural products, using Panax ginseng as a case study. P. ginseng is a widely used herb with a variety of therapeutic benefits, but its active ingredients and mechanisms of action on chronic diseases are not yet fully understood. Methods: Our study compiled and constructed a network focusing on P. ginseng by collecting and integrating data on ingredients, protein targets, and known indications. We then evaluated the performance of different network- based methods for summarizing known and unknown disease associations. The predicted results were validated in the hepatic stellate cell model. Results: We find that our multiscale interaction-based approach achieved an AUROC of 0.697 and an AUPR of 0.026, which outperforms other network-based approaches. As a case study, we further tested the ability of multiscale interactome-based approaches to identify active ingredients and their plausible mechanisms for breast cancer and liver cirrhosis. We also validated the beneficial effects of unreported and top-predicted ingredients, in cases of liver cirrhosis and gastrointestinal neoplasms. Conclusion: our study provides a promising framework to systematically explore the therapeutic effects and key mechanisms of natural products, and highlights the potential of network-based approaches in natural product research. | Kim, Young Woo; Bak, Seon Been; Song, Yu Rim; Kim, Chang-Eop; Lee, Won-Yung | Dongguk Univ, Sch Korean Med, Gyeongju, South Korea; Kyungpook Natl Univ, Dept Comp Sci, Daegu, South Korea; Gachon Univ, Sch Korean Med, Seongnam, South Korea; Wonkwang Univ, Sch Korean Med, Iksan 54538, South Korea; Wonkwang Univ, Res Ctr Tradit Korean Med, Iksan, South Korea | 55699527800; 57455566300; 57437229000; 57194146036; 57207303603 | wonyung21@wonkwang.ac.kr; | JOURNAL OF GINSENG RESEARCH | J GINSENG RES | 1226-8453 | 2093-4947 | 48 | 4 | SCIE | CHEMISTRY, MEDICINAL;INTEGRATIVE & COMPLEMENTARY MEDICINE | 2024 | 5.6 | 5.6 | 4.69 | 2025-05-07 | 9 | 9 | Network-based approach; Therapeutic effects; Panax ginseng | TRADITIONAL CHINESE MEDICINE; HEPATIC STELLATE CELL; QUALITY-OF-LIFE; RED GINSENG; PHARMACOLOGY; RG1 | Network-based approach; Panax ginseng; Therapeutic effects | ginseng extract; antiinflammatory activity; antineoplastic activity; Article; breast cancer; disease association; drug mechanism; gastrointestinal tumor; ginseng; hepatic stellate cell; liver cirrhosis; nonhuman; systems pharmacology; therapy effect | English | 2024 | 2024-07 | 10.1016/j.jgr.2024.01.005 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | The effects of Panax ginseng on growth enhancement, innate immunity, and microbiome profiling in Penaeus vannamei | Background: In aquaculture, feed additives are widely explored. Among them, Panax ginseng Meyer, a natural herbal remedy, has demonstrated its efficacy in many aquaculture species. However, research regarding Penaeus vannamei shrimp, one of the most significant species in aquaculture, remains limited. Methods: This study investigates the benefits of P. ginseng for P. vannamei, specifically its effects on growth, innate immunity, and shrimp microbiome. Juvenile P. vannamei were fed commercial feed mixed with red ginseng extract at 5 concentrations (0.00 %, 0.05 %, 0.10 %, 0.50 %, and 1.00 %) for 6 weeks. Body weight was measured on days 21 and 42. On day 42, three shrimp per group were selected for further analysis. Results: In the growth study, Group 0.10 % displayed significantly improved FBW, WG, SGR, and FCR compared to those in Group 0.00 % on day 42. The qPCR assay showed significantly higher IGF-BP gene expression in Groups 0.05%, 0.10 %, and 1.00 % compared to Group 0.00%. In the innate immunity analysis, SOD activity was significantly higher in Groups 0.05 % and 0.50 % compared to that in Group 0.00 %. In the bacterial community analysis, Group 0.10 % exhibited higher Flavobacteriaceae and lower Vibrionaceae at the family level compared to Group 0.00 %. At the genus level, Group 0.10 % showed increased unspecified Flavobacteriaceae and decreased Vibrio compared to Group 0.00 %. Conclusion: Adding P. ginseng to the feed enhanced growth, immune response, and microbiome composition in P. vannamei. Further research on refining dosage levels and utilizing red ginseng residues could boost commercial productivity and economic benefits in aquaculture practices. | Kim, Bumkeun; Jeon, Hye Jin; Rhee, Man Hee; Kim, Ji Hyung; Han, Jee Eun | Kyungpook Natl Univ, Coll Vet Med, Daegu 41566, South Korea; Kyungpook Natl Univ, Inst Vet Biomed Sci, Daegu 41556, South Korea; Gachon Univ, Dept Food Sci & Biotechnol, Seongnam 13120, South Korea | Rhee, Man/O-5705-2016; Kim, Ji Hyung/B-7321-2011 | 57225056167; 57212193058; 57211035357; 57225000204; 57214671240 | kzh81@gachon.ac.kr;jehan@knu.ac.kr; | JOURNAL OF GINSENG RESEARCH | J GINSENG RES | 1226-8453 | 2093-4947 | 48 | 6 | SCIE | CHEMISTRY, MEDICINAL;INTEGRATIVE & COMPLEMENTARY MEDICINE | 2024 | 5.6 | 5.6 | 0.59 | 2025-05-07 | 2 | 2 | Aquaculture; Feed additive; Microbiome analysis; Red ginseng; Shrimp | COGNITIVE PERFORMANCE; BODY-COMPOSITION; PROTEIN; CORTISOL; EXTRACT | Aquaculture; Feed additive; Microbiome analysis; Red ginseng; Shrimp | ginseng extract; animal experiment; animal food; aquaculture; Article; biochemical analysis; body weight; Flavobacteriaceae; ginseng; growth; immune response; innate immunity; microbial community; microbiome; nonhuman; Penaeus vannamei; Vibrionaceae | English | 2024 | 2024-11 | 10.1016/j.jgr.2024.06.002 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Meeting Abstract | Advanced fructo-oligosaccharides improve itching and aberrant epidermal lipid composition in children with atopic dermatitis. | Jang, Sehun; Kang, Bae-Gon; Sa, Soonok; Park, Se Young; Ryu, Kyun-Gheon; Lee, Jinyoung; Park, Boram; Kim, Jiwon; Shin, Sanghee; Song, Jeongmin; Kim, Byung Eui; Ahn, Kangmo; Liu, Kwang-Hyeon; Kim, Jihyun | Samsung Med Ctr, Seoul, South Korea; Kyungpook Natl Univ, Coll Pharm, Daegu, South Korea; Samyang Corp, Seoul, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Seoul, South Korea; Samsung Med Ctr, Res Inst Future Med, Seoul, South Korea; Natl Jewish Hlth, Denver, CO USA; Samsung Med Ctr, Dept Pediat, Seoul, South Korea | Park, Young/D-6811-2013; Ahn, Kangmo/F-4609-2014 | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | J ALLERGY CLIN IMMUN | 0091-6749 | 1097-6825 | 153 | 2 | SCIE | ALLERGY;IMMUNOLOGY | 2024 | 11.2 | 5.7 | 0 | English | 2024 | 2024-02 | 바로가기 | 바로가기 | |||||||||||||||
| ○ | Meeting Abstract | Alteration of gut microbiome in chronic urticaria | Kwon, Jae-Woo; Park, Han-Ki; Her, Young | Kangwon Natl Univ Hosp, Chunchon, South Korea; Kyungpook Natl Univ, Sch Med, Daegu, South Korea; Kangwon Natl Univ, Sch Med, Chunchon, South Korea | Her, Young/NHQ-1460-2025; Park, Han-Ki/AAY-3102-2020 | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | J ALLERGY CLIN IMMUN | 0091-6749 | 1097-6825 | 153 | 2 | SCIE | ALLERGY;IMMUNOLOGY | 2024 | 11.2 | 5.7 | 0 | English | 2024 | 2024-02 | 바로가기 | 바로가기 |
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