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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Hybrid nutraceutical of 2-ketoglutaric acid in improving inflammatory bowel disease: Role of prebiotics and TAK1 inhibitor | The main cause of inflammatory bowel disease (IBD) is abnormal intestinal permeability due to the disruption of the tight junction of the intestinal barrier through a pathogen-mediated inflammatory mechanism and an imbalance of the gut microbiota. This study aimed to evaluate whether 2-ketoglutaric acid alleviated permeability dysfunction with tight junction localization, activated the transforming growth factor beta-activated kinase 1 (TAK1) inflammation pathway, and regulated the homeostasis of the intestinal microbiome in vitro and in vivo IBD model. Our findings revealed that 2-ketoglutaric acid significantly suppressed abnormal intestinal permeability, delocalization of tight junction proteins from the intestinal cell, expression of inflammatory cytokines, such as TNF-alpha, both in vitro and in vivo. 2-Ketoglutaric acid was found to directly bind to TAK1 and inhibit the TNF receptor-associated factor 6 (TRAF6)-TAK1 interaction, which is related to the activation of nuclear factor kappa B (NF-kappa B) pathways, thereby regulating the expression of mitogen-activated protein kinase. Dietary 2-ketoglutaric acid also alleviated gut microbiota dysbiosis and IBD symptoms, as demonstrated by improvements in the intestine length and the abundance of Ligilactobacillus, CoriobacteriaceaeUCG₀₀₂, and Ruminococcaceaeᵤₙcₗₐₛₛᵢfᵢₑd in mice with colitis. This study indicated that 2-ketoglutaric acid binds to TAK1 for activity inhibition which is related to the NF-kappa B pathway and alleviates abnormal permeability by regulating tight junction localization and gut microbiome homeostasis. Therefore, 2-ketoglutaric acid is an effective nutraceutical agent and prebiotic for the treatment of IBD. | Kim, San; Jang, Se Hyeon; Kim, Min Jeong; Lee, Jeong Jae; Kim, Kyung-Min; Kim, Young Hoon; Lee, Ju-Hoon; Jung, Sung Keun | Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Kyungpook Natl Univ, Coll Agr & Life Sci, Sch Appl Biosci, Div Plant Biosci, Daegu 41566, South Korea; Kyungpook Natl Univ, Coastal Agr Res Inst, Daegu 41566, South Korea; Seoul Natl Univ, Inst Agr & Life Sci, Dept Agr Biotechnol & Res, Seoul 08826, South Korea; Seoul Natl Univ, Dept Food & Anim Biotechnol, Seoul 08826, South Korea; Seoul Natl Univ, Ctr Food & Bioconvergence, Seoul 08826, South Korea; Kyungpook Natl Univ, Res Inst Tailored Food Technol, Daegu 41566, South Korea | Jang, Hyeon/AAO-6009-2020; Kim, Young Hoon/F-5424-2012; Lee, Ju-Hoon/AAK-7256-2020; Jung, SUNG KEUN/AGR-2623-2022 | 58142092500; 58142092600; 57215818497; 55915465100; 34868260300; 57861979600; 54975259000; 35310491400 | skjung04@knu.ac.kr; | BIOMEDICINE & PHARMACOTHERAPY | BIOMED PHARMACOTHER | 0753-3322 | 1950-6007 | 171 | SCIE | MEDICINE, RESEARCH & EXPERIMENTAL;PHARMACOLOGY & PHARMACY | 2024 | 7.5 | 5.3 | 3.81 | 2025-05-07 | 7 | 8 | Inflammatory bowel disease; 2-ketoglutaric acid; Tight junction; Myosin light chain kinase; Transforming growth factor beta; activated ki; nase 1; Gut microbiota | ORGANIC-ACIDS; CANCER; MICROBIOTA; JUNCTION; COLITIS; CELLS | 2-ketoglutaric acid; Gut microbiota; Inflammatory bowel disease; Myosin light chain kinase; Tight junction; Transforming growth factor beta-activated kinase 1 | Animals; Colitis; Dextran Sulfate; Inflammatory Bowel Diseases; Intestinal Mucosa; Ketoglutaric Acids; Mice; Mice, Inbred C57BL; Myosin-Light-Chain Kinase; NF-kappa B; Prebiotics; Tight Junctions; 2 oxoglutaric acid; fluorescein isothiocyanate dextran; I kappa B kinase alpha; immunoglobulin enhancer binding protein; interleukin 1beta; mitogen activated protein kinase; myosin light chain; myosin light chain kinase; protein ZO1; transforming growth factor beta activated kinase 1; tumor necrosis factor; tumor necrosis factor receptor associated factor 6; 2 oxoglutaric acid; dextran sulfate; immunoglobulin enhancer binding protein; myosin light chain kinase; prebiotic agent; animal cell; animal experiment; animal model; animal tissue; antiinflammatory activity; Article; autophosphorylation; Caco-2 cell line; cell differentiation; cell permeabilization; cell viability; cellular distribution; controlled study; dextran sulfate sodium-induced colitis; drug megadose; dysbiosis; enzyme degradation; enzyme phosphorylation; female; homeostasis; human; human cell; immunofluorescence assay; immunoprecipitation; in vitro study; in vivo study; inflammatory bowel disease; intestine cell; intestine flora; intestine mucosa permeability; Ligilactobacillus; lipopolysaccharide-induced inflammation; low drug dose; mouse; NF kB signaling; nonhuman; population abundance; protein localization; protein protein interaction; real time reverse transcription polymerase chain reaction; transepithelial resistance; Western blotting; animal; C57BL mouse; colitis; inflammatory bowel disease; intestine mucosa; metabolism; tight junction | English | 2024 | 2024-02 | 10.1016/j.biopha.2024.116126 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Article | L-Cysteine mitigates ROS-induced apoptosis and neurocognitive deficits by protecting against endoplasmic reticulum stress and mitochondrial dysfunction in mouse neuronal cells | Oxidative stress and mitochondrial dysfunction play critical roles in neurodegenerative diseases. Glutathione (GSH), a key brain antioxidant, helps to neutralize reactive oxygen species (ROS) and maintain redox balance. We investigated the effectiveness of L-cysteine (L-Cys) in preventing apoptosis induced by the ROS generator 2,3-dimethoxy-1,4-naphthoquinone (DMNQ) in mouse hippocampal neuronal HT22 cells, as well as alleviating memory and cognitive impairments caused by the GSH synthesis inhibitor L-buthionine sulfoximine (BSO) in mice. DMNQ-induced apoptotic events in HT22 cells, including elevated cytosolic and mitochondrial ROS levels, DNA fragmentation, endoplasmic reticulum stress, and mitochondrial damage-mediated apoptotic pathways were dose-dependently abrogated by L-Cys (0.5–2 mM). The reduced intracellular GSH level, caused by DMNQ treatment, was restored by L-Cys cotreatment. Although L-Cys did not significantly restore GSH in the presence of BSO, it prevented DMNQ-induced ROS elevation, mitochondrial damage, and apoptosis. Furthermore, compared to N-acetylcysteine and GSH, L-Cys had higher 2,2-diphenyl-1-picrylhydrazyl and 2,2-azino-bis-3-ethylbenzothiazoline-6-sulphonic acid radical-scavenging activity. L-Cys also restored mitochondrial respiration capacity in DMNQ-treated HT22 cells by reversing mitochondrial fission–fusion dynamic balance. BSO administration (500 mg/kg/day) in mice led to neuronal deficits, including memory and cognitive impairments, which were effectively mitigated by oral L-Cys (15 or 30 mg/kg/day). L-Cys also reduced BSO-induced ROS levels in the mice hippocampus and cortex. These findings suggest that even though it does not contribute to intracellular GSH synthesis, exogenous L-Cys protects neuronal cells against oxidative stress-induced mitochondrial damage and apoptosis, by acting as a ROS scavenger, which is beneficial in ameliorating neurocognitive deficits caused by oxidative stress. © 2024 The Authors | Park, Shin Young; Kim, Ki Yun; Gwak, Dong Seol; Shin, Soon Young; Jun, Do Youn; Kim, Young Ho | Laboratory of Immunobiology, School of Life Science, College of Natural Sciences, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu, 41566, South Korea, AT-31 BIO Inc., Business Incubation Center, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu, 41566, South Korea; Laboratory of Immunobiology, School of Life Science, College of Natural Sciences, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu, 41566, South Korea, AT-31 BIO Inc., Business Incubation Center, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu, 41566, South Korea; Laboratory of Immunobiology, School of Life Science, College of Natural Sciences, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu, 41566, South Korea; Department of Biological Sciences, Sanghuh College of Life Sciences, Konkuk University, Seoul, 05029, South Korea; AT-31 BIO Inc., Business Incubation Center, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu, 41566, South Korea; Laboratory of Immunobiology, School of Life Science, College of Natural Sciences, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu, 41566, South Korea, AT-31 BIO Inc., Business Incubation Center, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu, 41566, South Korea | 57210165477; 57189898278; 59360242900; 55737188000; 19134667600; 57208312159 | ykim@knu.ac.kr; | Biomedicine and Pharmacotherapy | BIOMED PHARMACOTHER | 0753-3322 | 1950-6007 | 180 | SCIE | MEDICINE, RESEARCH & EXPERIMENTAL;PHARMACOLOGY & PHARMACY | 2024 | 7.5 | 5.3 | 1.09 | 2025-05-07 | 3 | Antioxidant neuroprotection; Glutathione depletion; L-cysteine; Mitochondrial damage; Oxidative stress; ROS scavenger | Animals; Antioxidants; Apoptosis; Buthionine Sulfoximine; Cell Line; Cognitive Dysfunction; Cysteine; Endoplasmic Reticulum Stress; Glutathione; Hippocampus; Male; Mice; Mitochondria; Neurons; Neuroprotective Agents; Oxidative Stress; Reactive Oxygen Species; 2,3 dimethoxy 1,4 naphthoquinone; acetylcysteine; alpha tocopherol; antioxidant; buthionine sulfoximine; cysteine; glutathione; glycine; reactive oxygen metabolite; antioxidant; buthionine sulfoximine; cysteine; glutathione; neuroprotective agent; reactive oxygen metabolite; ABTS radical scavenging assay; animal cell; animal experiment; animal model; animal tissue; antiapoptotic activity; antioxidant activity; Article; brain cortex; cognitive defect; concentration response; controlled study; cytosol; cytotoxicity; DNA fragmentation; dose response; DPPH radical scavenging assay; drug efficacy; drug potency; drug screening; endoplasmic reticulum stress; glutathione metabolism; hippocampus; HT22 cell line; male; memory disorder; mitochondrial dynamics; mitochondrial respiration; mitochondrion; molecular biology; mouse; nerve cell; neuroapoptosis; neuroprotection; nonhuman; novel object recognition test; oxidative stress; protein expression level; Y-maze test; animal; apoptosis; cell line; cognitive defect; drug effect; drug therapy; metabolism; oxidative stress; pathology; prevention and control | English | Final | 2024 | 10.1016/j.biopha.2024.117538 | 바로가기 | 바로가기 | 바로가기 | ||||||||
| ○ | ○ | Article | Macamide, a component of maca (Lepidium meyenii Walp) lipophilic extract, enhances myogenic differentiation via AKT/p38 signaling and attenuates dexamethasone-induced muscle atrophy | Maca (Lepidium meyenii) is a plant that grows in the central Andes region of Peru, and it has been reported to have various bioactive functions, such as improving or preventing osteoporosis, sexual dysfunction, and memory impairment. In this study, maca roots of various colors (yellow, red, or black) were extracted using different polar solvents (PE, HEX, or BuOH) to compare their effects on muscle differentiation. Among them, the red maca lipophilic extract, which showed the most effectiveness, was chosen for further investigation. Our results show that RMLE enhances muscle differentiation by inducing MyoD-E2A heterodimerization through the activation of the AKT/p38 pathway. Additionally, RMLE attenuated dexamethasone-induced muscle atrophy by inhibiting nuclear translocation of FoxO3a and expression of E3-ligase (MAFbx and MURF1) in vitro and in vivo. Therefore, based on these results suggest that lipophilic extract of maca, which can abundantly contain nonpolar compounds, macamides, can enhance the functional properties of maca in alleviating muscle homeostasis. | Chae, Jongbeom; Hahn, Dongyup; Nam, Ju-Ock | Kyungpook Natl Univ, Dept Food Sci & Biotechnol, Daegu 41566, South Korea; Kyungpook Natl Univ, Coll Agr & Life Sci, Sch Food Sci & Biotechnol, Inst Agr Sci & Technol, Daegu, South Korea; Kyungpook Natl Univ, Res Inst Tailored Food Technol, Daegu 41566, South Korea | 57204499421; 36554163400; 7201496105 | dohahn@knu.ac.kr;namjo@knu.ac.kr; | BIOMEDICINE & PHARMACOTHERAPY | BIOMED PHARMACOTHER | 0753-3322 | 1950-6007 | 172 | SCIE | MEDICINE, RESEARCH & EXPERIMENTAL;PHARMACOLOGY & PHARMACY | 2024 | 7.5 | 5.3 | 0.54 | 2025-05-07 | 1 | 1 | Lepidium meyenii Walp.; Muscle differentiation; Muscle atrophy; Macamide; Akt | MYOD FAMILY; PROTEIN | Akt; Lepidium meyenii Walp.; Macamide; Muscle atrophy; Muscle differentiation | Dexamethasone; Lepidium; Muscular Atrophy; Plant Extracts; Proto-Oncogene Proteins c-akt; 2 morpholino 8 phenylchromone; acetonitrile; atrogin 1; dexamethasone; dichloromethane; distilled water; glucocorticoid receptor; hexane; Lepidium meyenii extract; macaene derivative; macamide derivatve; macaridine derivative; mitogen activated protein kinase p38; muscle RING finger 1 protein; MyoD1 protein; myogenin; n (3 methoxybenzyl) benzyllinolenamide; n (3 methoxybenzyl)benzyllinoleamide; n (3 methoxybenzyl)oleamide; oleamide; polyethylene; protein kinase B; pyroxylin; solvent; transcription factor; transcription factor bhlh; transcription factor E2A; transcription factor FKHRL1; unclassified drug; dexamethasone; plant extract; protein kinase B; Akt signaling; animal cell; animal experiment; animal model; animal tissue; Article; C2C12 cell line; cell differentiation; clinical effectiveness; color; comparative study; controlled study; drug efficacy; enzyme activation; heterodimerization; in vitro study; in vivo study; Lepidium meyenii; lipophilicity; male; MAPK signaling; mouse; muscle atrophy; muscle development; nonhuman; plant root; protein expression; signal transduction; Lepidium; muscle atrophy | English | 2024 | 2024-03 | 10.1016/j.biopha.2024.116249 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Monotropein mitigates atopic dermatitis-like skin inflammation through JAK/STAT signaling pathway inhibition | Atopic dermatitis (AD) is a globally increasing chronic inflammatory skin disease with limited and potentially side-effect-prone treatment options. Monotropein is the predominant iridoid glycoside in Morinda officinalis How roots, which has previously shown promise in alleviating AD symptoms. This study aimed to systematically investigate the pharmacological effects of monotropein on AD using a 2, 4-dinitrochlorobenzene (DNCB)/ Der- matophagoides farinae extract (DFE)-induced AD mice and tumor necrosis factor (TNF)-alpha/interferon (IFN)gamma-stimulated keratinocytes. Oral administration of monotropein demonstrated a significant reduction in AD phenotypes, including scaling, erythema, and increased skin thickness in AD-induced mice. Histological analysis revealed a marked decrease in immune cell infiltration in skin lesions. Additionally, monotropein effectively downregulated inflammatory markers, encompassing pro-inflammatory cytokines, T helper (Th)1 and Th2 cytokines, and pro-inflammatory chemokines in skin tissues. Notably, monotropein also led to a considerable decrease in serum immunoglobulin (Ig)E and IgG2a levels. At a mechanistic level, monotropein exerted its antiinflammatory effects by suppressing the phosphorylation of Janus kinase / signal transducer and activator of transcription proteins in both skin tissues of AD-induced mice and TNF-alpha/IFN-gamma-stimulated keratinocytes. In conclusion, monotropein exhibited a pronounced alleviation of AD symptoms in the experimental models used. These findings underscore the potential application of monotropein as a therapeutic agent in the context of AD, providing a scientific basis for further exploration and development. | Yang, Inyoung; Jeong, Na-Hee; Choi, Young-Ae; Kwon, Taeg Kyu; Lee, Soyoung; Khang, Dongwoo; Kim, Sang-Hyun | Kyungpook Natl Univ, Sch Med, Dept Pharmacol, CMRI, Daegu, South Korea; Keimyung Univ, Sch Med, Dept Immunol, Daegu, South Korea; Korea Res Inst Biosci & Biotechnol, Funct Biomat Res Ctr, Jeongeup, South Korea; Gachon Univ, Sch Med, Dept Physiol, Incheon, South Korea; Kyungpook Natl Univ, Coll Adv Technol Convergence, Dept Innovat Pharmaceut Sci, Daegu, South Korea | ; Kim, Sang-Hyun/KQU-4555-2024 | 59163039100; 57194410234; 7404777420; 7202206057; 8537269200; 26039177500; 57210450420 | sylee@kribb.re.kr;dkhang@gachon.ac.kr;shkim72@knu.ac.kr; | BIOMEDICINE & PHARMACOTHERAPY | BIOMED PHARMACOTHER | 0753-3322 | 1950-6007 | 176 | SCIE | MEDICINE, RESEARCH & EXPERIMENTAL;PHARMACOLOGY & PHARMACY | 2024 | 7.5 | 5.3 | 1.09 | 2025-05-07 | 3 | 3 | Atopic dermatitis; Monotropein; Keratinocytes; Skin inflammation | CYTOKINES; CELLS | Atopic dermatitis; Keratinocytes; Monotropein; Skin inflammation | Animals; Anti-Inflammatory Agents; Cytokines; Dermatitis, Atopic; Dermatophagoides farinae; Dinitrochlorobenzene; Disease Models, Animal; Female; Humans; Immunoglobulin E; Inflammation; Iridoids; Janus Kinases; Keratinocytes; Mice; Mice, Inbred BALB C; Signal Transduction; Skin; STAT Transcription Factors; 1 chloro 2,4 dinitrobenzene; antiinflammatory agent; cytokine; immunoglobulin E; iridoid; Janus kinase; STAT protein; animal; atopic dermatitis; Bagg albino mouse; blood; Dermatophagoides farinae; disease model; drug effect; drug therapy; female; human; immunology; inflammation; keratinocyte; metabolism; mouse; pathology; signal transduction; skin | English | 2024 | 2024-07 | 10.1016/j.biopha.2024.116911 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Nanocarrier mediated co-delivery of phytochemicals and chemo-drugs: an emerging strategy to combat lung cancer in a systemic way | Lung cancer is listed as one of the hotfooted malignancies on the basis of mortality and morbidity. Thus, emergence of new targeting and immunotherapies is being recognized that later invited drug resistance. Therefore, a new strategic formulation of phytochemicals as potent antitumor has been beautifully adapted. Elimination of cancer cells preferentially through cell cycle arrest and apoptosis with negligible toxic effects seems to be the major theme in cancer treatment. Recently, the application of phytochemical-derived conjugated chemotherapeutic agents is gaining preference due to their biocompatibility, low cytotoxicity, low resistance and dynamic physico-chemical properties that discriminate normal cells from treated populations. A systematic evaluation of biological interactions of functional phytocompounds with respect to their synthetic counterparts always receives priority from entry, biodistribution, cellular/molecular interactions to excretion. Nanotechnology has revolutionized cancer therapy, including lung cancer. Tissue-specific phyto-nanomedicines using liposomes, micelles and nanoparticles as precise and effective delivery vehicles are making regular breakthroughs in the field of diagnostics. This article precisely summarizes the achievements by Food and Drug Administration, USA approved therapeutic phytomolecules in conjugation with phyto-chemopreventives for clinical trials. Furthermore, it justifies, how the selection of nanocarriers and the best pair of phytomedicine/chemodrugs are important determinants of therapy benefits. In addition, a detailed coverage is given to describe the long journey of phytochemicals in synergy with chemo-preventive from agro-field to medical field and their graceful transformation on the platform of nanotechnology as an anticancer drug. However, it is equally important to address current challenges and future perspectives. | Upadhyay, Priyanka; Ghosh, Avijit; Sarangthem, Vijaya; Singh, Thoudam Debraj | All India Inst Med Sci, Dept Med Oncol Lab, New Delhi 110029, India; Univ Calcutta, Ctr Res Nanosci & Nanotechnol, Technol Campus,Salt Lake, Kolkata 700106, West Bengal, India; Kyungpook Natl Univ, Cell & Matrix Res Inst, Sch Med, Dept Biochem & Cell Biol, Daegu 41944, South Korea | ; Ghosh, Avijit/JMN-2589-2023 | 57189309990; 57205229133; 56001741200; 55190689800 | debraj.thoudam@gmail.com; | PHYTOCHEMISTRY REVIEWS | PHYTOCHEM REV | 1568-7767 | 1572-980X | 23 | 2 | SCIE | PLANT SCIENCES | 2024 | 7.6 | 5.3 | 1.09 | 2025-05-07 | 7 | 7 | Lung cancer; Phytochemicals; Chemotherapy; Apoptosis; Cell cycle arrest | REFRACTORY SOLID TUMORS; PHASE-I TRIAL; GOLD NANOPARTICLES; DIETARY PHYTOCHEMICALS; MULTIDRUG-RESISTANCE; ANTICANCER ACTIVITY; BREAST-CANCER; SILVER NANOPARTICLES; GENE-EXPRESSION; GREEN SYNTHESIS | Apoptosis; Cell cycle arrest; Chemotherapy; Lung cancer; Phytochemicals | alkaloid; antineoplastic agent; carotenoid; liposome; monoterpene; nanocarrier; nanoparticle; phytochemical; piperazinedione; piperidine; polyphenol; terpene derivative; Angelica keiskei; antineoplastic activity; Apis mellifera; apoptosis; Artemisia annua; Atractylodes macrocephala; Camellia sinensis; cancer cell; cancer therapy; cell cycle arrest; drug cytotoxicity; drug delivery system; drug excretion; drug formulation; drug structure; garlic; human; lung cancer; micelle; nanotechnology; Review | English | 2024 | 2024-04 | 10.1007/s11101-023-09894-9 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Side-by-side placement of fully covered metal stents versus conventional 7F plastic stents in malignant hilar biliary obstruction: Prospective randomized controlled trial | ObjectivesWe aimed to evaluate the efficacy and safety of metal stents compared with plastic stents when bilateral side-by-side stents were deployed for malignant hilar biliary obstruction (MHBO).MethodsFifty patients with unresectable advanced MHBO were randomly assigned to the metal stent (MS, n = 25) or plastic stent group (PS, n = 25). Fully covered self-expandable metal stents with 6 mm diameter and plastic stents with either 7F straight or double pigtail were used for MS and PS groups, respectively. Time to recurrent biliary obstruction (TRBO) was evaluated as the primary outcome.ResultsBoth groups had 100% technical success rates; 88% and 76% of clinical success rates were obtained in MS and PS, respectively. Although stent migrations were more frequent in MS than PS (48% vs. 16%, P = 0.02), the mean TRBO was significantly longer in MS (190 days; 95% confidence interval [CI] 121-260 days vs. 96 days; 95% CI 50-141 days, P = 0.02). The placement of plastic stents (hazard ratio 2.42; 95% CI 1.24-4.73; P = 0.01) was the only significant risk factor associated with TRBO in multivariable analysis. The rates of adverse events were similar between the two groups (difference 0%; 95% CI -25% to 25%; P > 0.99).ConclusionsDuring bilateral side-by-side deployment in MHBO, the use of metal stents appears to be preferable to plastic stents in terms of TRBO, despite a higher frequency of stent migration. | Paik, Woo Hyun; Jung, Min Kyu; Kim, Dong Uk; Song, Tae Jun; Yang, Min Jae; Choi, Young Hoon; Kim, Joo Seong; Lee, Min Woo; Choi, Jin Ho; Lee, Sang Hyub | Seoul Natl Univ, Dept Internal Med, Coll Med, 101 Daehak Ro, Seoul 110744, South Korea; Seoul Natl Univ, Seoul Natl Univ Hosp, Liver Res Inst, Coll Med, 101 Daehak Ro, Seoul 110744, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Gastroenterol, Seoul, South Korea; Catholic Univ Korea, Coll Med, Dept Internal Med, Seoul, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Med, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Pusan Natl Univ, Coll Med, Dept Internal Med, Yangsan, South Korea; Pusan Natl Univ Hosp, Biomed Res Inst, Pusan, South Korea; Ajou Univ, Sch Med, Dept Gastroenterol, Suwon, South Korea; Dongguk Univ, Med Ctr, Dept Internal Med, Coll Med, Goyang, South Korea; Armed Forces Capital Hosp, Dept Internal Med, Seongnam, South Korea | ; Paik, Woo Hyun/B-9003-2016; KANG, MIN KYU/ACI-8824-2022; Kim, Ik-Sang/J-5425-2012; Song, Taejun/JVZ-2733-2024; Lee, Min Woo/HNR-7224-2023; Paik, Woo/B-9003-2016 | 35822559900; 56783168100; 55742956600; 26028951400; 55964785900; 57212256431; 57194070052; 57577738900; 57202894976; 36062488800 | gidoctor@snu.ac.kr; | DIGESTIVE ENDOSCOPY | DIGEST ENDOSC | 0915-5635 | 1443-1661 | 36 | 4 | SCIE | GASTROENTEROLOGY & HEPATOLOGY;SURGERY | 2024 | 4.7 | 5.3 | 4.05 | 2025-05-07 | 5 | 6 | cholestasis; endoscopic retrograde cholangiopancreatography; Klatskin; palliation | UNILATERAL PLACEMENT; STRICTURES; MULTICENTER; MANAGEMENT; MIGRATION; DRAINAGE | cholestasis; endoscopic retrograde cholangiopancreatography; Klatskin; palliation | Bile Duct Neoplasms; Cholestasis; Humans; Prospective Studies; Prosthesis Implantation; Retrospective Studies; Self Expandable Metallic Stents; Stents; Treatment Outcome; acute cholecystitis; adult; advanced cancer; aged; Article; biliary tract cancer; cancer palliative therapy; cholangitis; cholestasis; clinical article; clinical outcome; comparative effectiveness; controlled study; device safety; distant metastasis; endoscopic retrograde cholangiopancreatography; female; gallbladder cancer; human; in-stent restenosis; intrahepatic cholangiocarcinoma; Klatskin tumor; liver abscess; male; malignant hilar biliary obstruction; middle aged; outcome assessment; palliative chemotherapy; prospective study; randomized controlled trial; recurrent disease; risk factor; stent migration; very elderly; bile duct tumor; cholestasis; complication; prosthesis implantation; retrospective study; self expandable metallic stent; stent; treatment outcome | English | 2024 | 2024-04 | 10.1111/den.14669 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Review | Taming neuroinflammation in Alzheimer's disease: The protective role of phytochemicals through the gut-brain axis | Alzheimer's disease (AD) is a progressive degenerative neurological condition characterized by cognitive decline, primarily affecting memory and logical thinking, attributed to amyloid-(3 plaques and tau protein tangles in the brain, leading to neuronal loss and brain atrophy. Neuroinflammation, a hallmark of AD, involves the activation of microglia and astrocytes in response to pathological changes, potentially exacerbating neuronal damage. The gut-brain axis is a bidirectional communication pathway between the gastrointestinal and central nervous systems, crucial for maintaining brain health. Phytochemicals, natural compounds found in plants with antioxidant and anti-inflammatory properties, such as flavonoids, curcumin, resveratrol, and quercetin, have emerged as potential modulators of this axis, suggesting implications for AD prevention. Intake of phytochemicals influences the gut microbial composition and its metabolites, thereby impacting neuroinflammation and oxidative stress in the brain. Consumption of phytochemical-rich foods may promote a healthy gut microbiota, fostering the production of anti-inflammatory and neuroprotective substances. Early dietary incorporation of phytochemicals offers a non-invasive strategy for modulating the gut-brain axis and potentially reducing AD risk or delaying its onset. The exploration of interventions targeting the gut-brain axis through phytochemical intake represents a promising avenue for the development of preventive or therapeutic strategies against AD initiation and progression. | Kim, Yoonsu; Lim, Jinkyu; Oh, Jisun | Kyungpook Natl Univ, Dept Integrat Biol, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Daegu Gyeongbuk Med Innovat Fdn, New Drug Dev Ctr, Daegu 41061, South Korea | 57219254485; 7403454071; 56311554100 | jkylim@knu.ac.kr;joh@kmedihub.re.kr; | BIOMEDICINE & PHARMACOTHERAPY | BIOMED PHARMACOTHER | 0753-3322 | 1950-6007 | 178 | SCIE | MEDICINE, RESEARCH & EXPERIMENTAL;PHARMACOLOGY & PHARMACY | 2024 | 7.5 | 5.3 | 3.61 | 2025-05-07 | 18 | 20 | Neuroinflammation; Alzheimer's disease; Phytochemicals; Gut-brain axis; Prevention | ISCHEMIA-REPERFUSION INJURY; SULFATE-REDUCING BACTERIA; GINKGO-BILOBA EXTRACT; AMYLOID-BETA; MOUSE MODEL; NEURODEGENERATIVE DISEASES; PRECURSOR PROTEIN; OXIDATIVE STRESS; DIETARY PHYTOCHEMICALS; THERAPEUTIC TARGETS | Alzheimer's disease; Gut-brain axis; Neuroinflammation; Phytochemicals; Prevention | Alzheimer Disease; Animals; Anti-Inflammatory Agents; Antioxidants; Brain; Brain-Gut Axis; Gastrointestinal Microbiome; Humans; Neuroinflammatory Diseases; Neuroprotective Agents; Oxidative Stress; Phytochemicals; curcumin; flavonoid; phytochemical; quercetin; resveratrol; tau protein; antiinflammatory agent; antioxidant; neuroprotective agent; phytochemical; adult; Alzheimer disease; animal model; animal tissue; astrocyte; brain atrophy; brain-gut axis; cognitive defect; controlled study; drug therapy; female; human; intestine flora; logical reasoning; memory; microglia; nervous system inflammation; neuroprotection; nonhuman; oxidative stress; pharmacology; prevention; review; therapy; animal; brain; drug effect; intestine flora; metabolism; pathology; physiology; prevention and control | English | 2024 | 2024-09 | 10.1016/j.biopha.2024.117277 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | TNF receptor 2 knockout mouse had reduced lung cancer growth and schizophrenia-like behavior through a decrease in TrkB-dependent BDNF level | The relationship between schizophrenia (SCZ) and cancer development remains controversial. Based on the disease-gene association platform, it has been revealed that tumor necrosis factor receptor (TNFR) could be an important mediatory factor in both cancer and SCZ development. TNF-alpha also increases the expression of brain-derived neurotrophic factor (BDNF) and tropomyosin receptor kinase B (TrkB) in the development of SCZ and tumor, but the role of TNFR in mediating the association between the two diseases remains unclear. We studied the vital roles of TNFR2 in the progression of tumor and SCZ-like behavior using A549 lung cancer cell xenografted TNFR2 knockout mice. TNFR2 knockout mice showed significantly decreased tumor size and weight as well as schizophrenia-like behaviors compared to wild-type mice. Consistent with the reduced tumor growth and SCZ-like behaviors, the levels of TrkB and BDNF expression were significantly decreased in the lung tumor tissues and pre-frontal cortex of TNFR2 knockout mice. However, intravenous injection of BDNF (160 mu g/kg) to TNFR2 knockout mice for 4 weeks increased tumor growth and SCZ-like behaviors as well as TrkB expression. In in vitro study, significantly decreased cell growth and expression of TrkB and BDNF by siTNFR2 transfection were found in A549 lung cancer cells. However, the addition of BDNF (100 ng/ml) into TNFR2 siRNA transfected A549 lung cancer cells recovered cell growth and the expression of TrkB. These results suggest that TNFR2 could be an important factor in mediating the comorbidity between lung tumor growth and SCZ development through increased TrkB-dependent BDNF levels. | Yeo, In Jun; Yu, Ji Eun; Kim, Sung-Hyun; Kim, Dae Hwan; Jo, Miran; Son, Dong Ju; Yun, Jaesuk; Han, Sang-Bae; Hong, Jin Tae | Chungbuk Natl Univ, Coll Pharm, 194-21 Osongsaengmyeong 1 Ro, Cheongju 28160, Chungbuk, South Korea; Chungbuk Natl Univ, Med Res Ctr, 194-21 Osongsaengmyeong 1 Ro, Cheongju 19431, Chungbuk, South Korea; Kyungpook Natl Univ, Coll Pharm, 80 Daehak Ro, Daegu 41566, South Korea; Mokpo Natl Univ, Coll Pharm, 1666 Yeongsan Ro, Muan gun 58554, Jeonnam, South Korea | 57201941942; 56682243900; 59104160800; 57203718634; 44761156900; 7101868468; 15733177200; 57216616464; 55657116500 | shan@chungbuk.ac.kr;jinthong@chungbuk.ac.kr; | ARCHIVES OF PHARMACAL RESEARCH | ARCH PHARM RES | 0253-6269 | 1976-3786 | 47 | 4 | SCIE | CHEMISTRY, MEDICINAL;PHARMACOLOGY & PHARMACY | 2024 | 7.5 | 5.3 | 0.91 | 2025-05-07 | 4 | 4 | Cancer; Schizophrenia; TNFR2; BDNF; TrkB; TNF-alpha | NEUROTROPHIC FACTOR; BIPOLAR DISORDER; RISK; HYPOTHESIS; GENES; ONSET | BDNF; Cancer; Schizophrenia; TNF-α; TNFR2; TrkB | A549 Cells; Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cell Proliferation; Humans; Lung Neoplasms; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptor, trkB; Receptors, Tumor Necrosis Factor, Type II; Schizophrenia; brain derived neurotrophic factor; brain derived neurotrophic factor receptor; small interfering RNA; tumor necrosis factor receptor 2; Bdnf protein, mouse; brain derived neurotrophic factor; brain derived neurotrophic factor receptor; membrane protein; Ntrk2 protein, mouse; Tnfrsf1b protein, mouse; tropomyosin-related kinase-B, human; tumor necrosis factor receptor 2; A-549 cell line; animal behavior; animal cell; animal experiment; animal model; animal tissue; Article; brain tissue; cancer growth; cancer tissue; cell growth; comorbidity; concentration (parameter); controlled study; disease exacerbation; human; human cell; in vitro study; knockout mouse; lung cancer; male; mouse; nonhuman; prefrontal cortex; protein expression level; protein function; schizophrenia; tumor xenograft; weight; wild type; animal; C57BL mouse; cell proliferation; drug effect; genetics; lung tumor; metabolism; pathology; schizophrenia | English | 2024 | 2024-04 | 10.1007/s12272-024-01487-0 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Classification of geogrid reinforcement in aggregate using machine learning techniques | The present study proposes a novel ML methodology for differentiating between unstabilized aggregate specimens and those stabilized with triangular and rectangular aperture geogrids. This study utilizes the compiled experimental results obtained from stabilized and unstabilized specimens under repeated loading into a balanced, moderate-sized database. The efficacy of five ML models, including tree-ensemble and single-learning algorithms, in accurately identifying each specimen class was explored. Shapley's additive explanation was used to understand the intricacies of the models and determine global feature importance ranking of the input variables. All the models could identify the unstabilized specimen with an accuracy of at least 0.9. The tree-ensemble models outperformed the single-learning models when all three classes (unstabilized specimens and specimens stabilized by triangular and rectangular aperture geogrids) were considered, with the light gradient boosting machine showing the best performance-an accuracy of 0.94 and an area under the curve score of 0.98. According to Shapley's additive explanation, the resilient modulus and confining pressure were identified as the most important features across all models. Therefore, the proposed ML methodology may be effectively used to determine the type and presence of geogrid reinforcement in aggregates, based on a few aggregate material properties and performance under repeated loading. | Aregbesola, Samuel Olamide; Byun, Yong-Hoon | Kyungpook Natl Univ, Dept Agr Civil Engn, 80 Daehak-ro, Daegu 41566, South Korea | ; Aregbesola, Samuel/LXV-8805-2024; Byun, Yong-Hoon/JKI-8441-2023 | 58631316600; 42761048000 | yhbyun@knu.ac.kr; | INTERNATIONAL JOURNAL OF GEO-ENGINEERING | INT J GEO-ENG | 2092-9196 | 2198-2783 | 15 | 1 | ESCI | ENGINEERING, GEOLOGICAL | 2024 | 7.1 | 5.4 | 3.06 | 2025-05-07 | 11 | 12 | Aggregate; Classification; Feature importance; Geogrid reinforcement; Machine learning | STABILIZED AGGREGATE; PREDICTION; ROADS | Aggregate; Classification; Feature importance; Geogrid reinforcement; Machine learning | English | 2024 | 2024-02-12 | 10.1186/s40703-024-00206-4 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Controlled low strength material modified with lignosulfonate | Controlled low-strength materials (CLSM) have been used for conventional backfilling and structural filling owing to their flowability, self-consolidating, and self-leveling features. This study investigates the rheological, mechanical, and dynamic characteristics of lignosulfonate-modified CLSM. The elemental analysis of lignosulfonate reveals the presence of various elements and an irregular morphology, as observed using a scanning electron microscope. A series of tests, including flow tests, Vicat needle tests, uniaxial compression tests, and shear wave monitoring, are conducted to evaluate the flowability, setting time, strength, and shear wave velocity of lignosulfonate-modified CLSM. The experimental results show that the flowability and initial and final setting times of the CLSM mixtures increase with increasing lignosulfonate content (LC), which improves workability in the field but results in a slight strength loss. Regarding the uniaxial compressive strength, CLSM mixtures with lower LC exhibit a rapid increase in strength during the early stages, while those with higher LC show higher performance on the 14th day of curing. In contrast, an LC of 0.21% led to a slight reduction in the strength on the 28th day. The current study also shows an exponential correlation between the uniaxial compressive strength and shear wave velocity. | Heo, Yoon Geom; Son, Dong Geon; Babatunde, Quadri Olakunle; Byun, Yong-Hoon | Kyungpook Natl Univ, Dept Agr Civil Engn, 80 Daehak Ro, Daegu 41566, South Korea; Korea Univ, Sch Civil Environm & Architectural Engn, 145 Anam Ro, Seoul 02841, South Korea | ; Byun, Yong-Hoon/JKI-8441-2023 | 58574724200; 58490365100; 58102290600; 42761048000 | yhbyun@knu.ac.kr; | INTERNATIONAL JOURNAL OF GEO-ENGINEERING | INT J GEO-ENG | 2092-9196 | 2198-2783 | 15 | 1 | ESCI | ENGINEERING, GEOLOGICAL | 2024 | 7.1 | 5.4 | 0 | 2025-05-07 | 1 | 1 | Compressive strength; Controlled low-strength material; Lignosulfonate; Shear wave | SOIL; BEHAVIOR; LIGNIN; STABILIZATION; PERFORMANCE | Compressive strength; Controlled low-strength material; Lignosulfonate; Shear wave | English | 2024 | 2024-12-20 | 10.1186/s40703-024-00229-x | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Electrical stimulation promotes functional recovery after spinal cord injury by activating endogenous spinal cord-derived neural stem/progenitor cell: an in vitro and in vivo study | BACKGROUND CONTEXT: Electrical stimulation is a noninvasive treatment method that has gained popularity in the treatment of spinal cord injury (SCI). Activation of spinal cord -derived neural stem/progenitor cell (SC-NSPC) proliferation and differentiation in the injured spinal cord may elicit considerable neural regenerative effects. PURPOSE: This study aimed to explore the effect of electrical stimulation on the neurogenesis of SC-NSPCs. STUDY DESIGN: This study analyzed the effects of electrical stimulation on neurogenesis in rodent SC-NSPCs in vitro and in vivo and evaluated functional recovery and neural circuitry improvements with electrical stimulation using a rodent SCI model. METHODS: Rats (20 rats/group) were assigned to sham (Group 1), SCI only (Group 2), SCI + electrode implant without stimulation (Group 3), and SCI + electrode with stimulation (Group 4) groups to count total SC-NSPCs and differentiated neurons and to evaluate morphological changes in differentiated neurons. Furthermore, the Basso, Beattie, and Bresnahan scores were analyzed, and the motor- and somatosensory-evoked potentials in all rats were monitored. RESULTS: Biphasic electrical currents enhanced SC-NSPC proliferation differentiation and caused qualitative morphological changes in differentiated neurons in vitro. Electrical stimulation promoted SC-NSPC proliferation and neuronal differentiation and improved functional outcomes and neural circuitry in SCI models. Increased Wnt3, Wnt7, and b-catenin protein levels were also observed after electrical stimulation. CONCLUSIONS: Our study proved the beneficial effects of electrical stimulation on SCI. The Wnt/b-catenin pathway activation may be associated with this relationship between electrical stimulation and neuronal regeneration after SCI. CLINICAL SIGNIFICANCE: The study confirmed the benefits of electrical stimulation on SCI based on cellular, functional, electrophysiological, and histological evidence. Based on these findings, we expect electrical stimulation to make a positive and significant difference in SCI treatment strategies. (c) 2023 Published by Elsevier Inc. | Bang, Woo-Seok; Han, Inbo; Mun, Seul-Ah; Hwang, Jong -Moon; Noh, Sung Hyun; Son, Wonsoo; Cho, Dae-Chul; Kim, Byoung-Joon; Kim, Chi Heon; Choi, Hyuk; Kim, Kyoung-Tae | Topspine Hosp, Dept Neurosurg, Daegu, South Korea; CHA Univ, CHA Bundang Med Ctr, Dept Neurosurg, Seongnam Si 13496, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Neurosurg, Daegu, South Korea; Daegu Fatima Hosp, Dept Rehabil Med, Daegu, South Korea; Ajou Univ, Sch Med, Dept Neurosurg, Suwon, South Korea; Seoul Natl Univ, Coll Med, Dept Neurosurg, Seoul, South Korea; Korea Univ, Grad Sch Med, Dept Med Sci, Seoul, South Korea | ; Kim, Chi/J-6536-2019; Choi, Hyuk/AFH-7760-2022 | 55848366100; 9338449900; 57216694404; 56367634000; 57194978247; 36676729400; 55859543400; 57201448189; 35145892000; 55557143200; 57201369790 | woosugi14@naver.com;hanib@cha.c.kr;dp3942@naver.com;hti82@hanmail.net;juwuman12@gmail.com;wsson22@hanmail.net;dccho@knu.ac.kr;bjkimknuh@gmail.com;chiheon1@snu.ac.kr;hyuk76@korea.ac.kr;nskimkt7@gmail.com; | SPINE JOURNAL | SPINE J | 1529-9430 | 1878-1632 | 24 | 3 | SCIE | CLINICAL NEUROLOGY;ORTHOPEDICS | 2024 | 4.7 | 5.4 | 4.94 | 2025-05-07 | 9 | 8 | Biphasic electrical current; Neural stem/progenitor cells; Spinal cord injury; Wnt signaling | EMBRYONIC STEM-CELLS; CORTICOSPINAL TRACT; PROGENITOR CELLS; DIFFERENTIATION; EXPRESSION; RATS; TRANSPLANTATION; NEUROGENESIS; NEURONS; NEUROTROPHINS | Biphasic electrical current; Neural stem/progenitor cells; Spinal cord injury; Wnt signaling | Animals; Cell Differentiation; Neural Stem Cells; Rats; Recovery of Function; Spinal Cord; Spinal Cord Injuries; Wnt Signaling Pathway; beta catenin; adult; animal experiment; animal model; animal tissue; Article; cell culture; cell proliferation; controlled study; electric current; electrophysiological procedures; electrostimulation; in vitro study; in vivo study; nerve cell differentiation; nerve cell network; nerve regeneration; nervous system development; neural stem cell; non invasive procedure; nonhuman; rat; signal transduction; somatosensory evoked potential; spinal cord; spinal cord injury; Wnt signaling; animal; cell differentiation; convalescence; metabolism; pathology; spinal cord injury; transplantation | English | 2024 | 2024-03 | 10.1016/j.spinee.2023.10.004 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Generation of synthetic PET/MR fusion images from MR images using a combination of generative adversarial networks and conditional denoising diffusion probabilistic models based on simultaneous 18F-FDG PET/MR image data of pyogenic spondylodiscitis | BACKGROUND CONTEXT: Cross-modality image generation from magnetic resonance (MR) to positron emission tomography (PET) using the generative model can be expected to have complementary effects by addressing the limitations and maximizing the advantages inherent in each modality. PURPOSE: This study aims to generate synthetic PET/MR fusion images from MR images using a combination of generative adversarial networks (GANs) and conditional denoising diffusion probabilistic models (cDDPMs) based on simultaneous 18 F-fluorodeoxyglucose (18F-FDG) PET/MR image data. STUDY DESIGN: Retrospective study with prospectively collected clinical and radiological data. PATIENT SAMPLE: This study included 94 patients (60 men and 34 women) with thoraco-lumbar pyogenic spondylodiscitis (PSD) from February 2017 to January 2020 in a single tertiary institution. OUTCOME MEASURES: Quantitative and qualitative image similarity were analyzed between the real and synthetic PET/ T2-weighted fat saturation MR (T2FS) fusion images on the test data set. METHODS: We used paired spinal sagittal T2FS and PET/T2FS fusion images of simultaneous 18F-FDG PET/MR imaging examination in patients with PSD, which were employed to generate synthetic PET/T2FS fusion images from T2FS images using a combination of Pix2Pix (U-Net generator + Least Squares GANs discriminator) and cDDPMs algorithms. In the analyses of image similarity between the real and synthetic PET/T2FS fusion images, we adopted the values of mean peak signal to noise ratio (PSNR), mean structural similarity measurement (SSIM), mean absolute error (MAE), and mean squared error (MSE) for quantitative analysis, while the discrimination accuracy by three spine surgeons was applied for qualitative analysis. RESULTS: Total of 2,082 pairs of T2FS and PET/T2FS fusion images were obtained from 172 examinations on 94 patients, which were randomly assigned to training, validation, and test data sets in 8:1:1 ratio (1664, 209, and 209 pairs). The quantitative analysis revealed PSNR of 30.634 +/- 3.437, SSIM of 0.910 +/- 0.067, MAE of 0.017 +/- 0.008, and MSE of 0.001 +/- 0.001, respectively. The values of PSNR, MAE, and MSE significantly decreased as FDG uptake increased in real PET/T2FS fusion image, with no significant correlation on SSIM. In the qualitative analysis, the overall discrimination accuracy between real and synthetic PET/T2FS fusion images was 47.4%. CONCLUSIONS: The combination of Pix2Pix and cDDPMs demonstrated the potential for crossmodal image generation from MR to PET images, with reliable quantitative and qualitative image similarities. (c) 2024 Elsevier Inc. All rights reserved. | Jung, Euijin; Kong, Eunjung; Yu, Dongwoo; Yang, Heesung; Chicontwe, Philip; Park, Sang Hyun; Jeon, Ikchan | DGIST, Dept Robot & Mechatron Engn, Daegu, South Korea; Yeungnam Univ, Coll Med, Dept Nucl Med, Yeungnam Univ Hosp, Daegu, South Korea; Yeungnam Univ, Coll Med, Dept Neurosurg, Yeungnam Univ Hosp, Daegu, South Korea; Kyungpook Natl Univ, Sch Comp Sci & Engn, Daegu, South Korea | ; CHIKONTWE, PHILIP/P-8291-2019; Jeon, Ikchan/AAZ-6368-2020 | 57207112410; 37007708500; 57217215304; 58175679600; 59090373500; 57188954175; 26424321100 | jicns@ynu.ac.kr; | SPINE JOURNAL | SPINE J | 1529-9430 | 1878-1632 | 24 | 8 | SCIE | CLINICAL NEUROLOGY;ORTHOPEDICS | 2024 | 4.7 | 5.4 | 0.82 | 2025-05-07 | 1 | 1 | Cross -modality; Diffusion model; FDG PET/MRI; Generative adversarial networks; Spine | COMPUTED-TOMOGRAPHY; INFECTION | Cross-modality; Diffusion model; FDG PET/MRI; Generative adversarial networks; Spine | Adult; Aged; Discitis; Female; Fluorodeoxyglucose F18; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Models, Statistical; Multimodal Imaging; Positron-Emission Tomography; Radiopharmaceuticals; Retrospective Studies; antibiotic agent; fluorodeoxyglucose f 18; gadoterate meglumine; radiopharmaceutical agent; Article; conditional denoising diffusion probabilistic model; data extraction; diagnostic accuracy; female; generative adversarial network; generative model; human; image analysis; intervertebral disk degeneration; least square analysis; major clinical study; male; mean absolute error; mean squared error; positron emission tomography; pyogenic spondylodiscitis; qualitative analysis; quantitative analysis; retrospective study; signal noise ratio; T1 weighted imaging; T2 weighted imaging; treatment response; adult; aged; diagnostic imaging; diskitis; image processing; middle aged; multimodal imaging; nuclear magnetic resonance imaging; procedures; statistical model | English | 2024 | 2024-08 | 10.1016/j.spinee.2024.04.007 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Genetic diversity and Wolbachia infection in the Japanese encephalitis virus vector Culex tritaeniorhynchus in the Republic of Korea | BackgroundCulex tritaeniorhynchus, a major vector of Japanese encephalitis virus (JEV), is found across a broad geographical range, including Africa, Asia, Australia and Europe. Understanding the population structure and genetic diversity of pathogen vectors is increasingly seen as important for effective disease control. In China and Japan, two countries in close proximity to the Republic of Korea (ROK), Cx. tritaeniorhynchus has been categorized into two clades based on the DNA barcoding region of mitochondrial cytochrome c oxidase subunit I (COI), suggesting the presence of cryptic species. No comprehensive analysis of the genetic diversity in Cx. tritaeniorhynchus has been conducted in the ROK. To address this gap, we investigated the population structure of Cx. tritaeniorhynchus in the ROK.MethodsIn Daegu, mosquito collections were conducted over a 2-year period from 2022 to 2023. For all other regions, Cx. tritaeniorhynchus specimens collected in 2023 were used. The COI barcoding region was analyzed to determine the genetic structure of the populations, supplemented with data from the 28S ribosomal DNA region. Each population was also examined for the eventual presence of Wolbachia infection. Finally, a back trajectory analysis was conducted to assess the possibility of international introduction of Cx. tritaeniorhynchus into the ROK.ResultsThe analysis of the COI region revealed the presence of two distinct clades within Cx. tritaeniorhynchus; these clades were the same as Cx. tritaeniorhynchus continental type (Ct-C) and C. tritaeniorhynchus Japanese type (Ct-J) previously reported. In contrast, the nuclear 28S region showed no significant genetic differentiation between these clades. Wolbachia infection was confirmed in some populations, but there was no evidence of an association with Wolbachia in Ct-C and Ct-J. It was also confirmed that the ROK is currently dominated by the Ct-J clade, with a possible introduction of Ct-C via air currents.ConclusionsDetermining the presence of cryptic species is important for preventing vector-borne diseases. The results of this study confirm the existence of two clades of Cx. tritaeniorhynchus in the ROK, with Ct-J being the dominant clade. Our findings enhance current understanding of the genetic diversity within Cx. tritaeniorhynchus and provide valuable insights for the prevention of JEV outbreaks and the effective management of Cx. tritaeniorhynchus populations in East Asia. | Jeon, Jiseung; Kim, Heung Chul; Donnelly, Martin J.; Choi, Kwang Shik | Kyungpook Natl Univ, Coll Nat Sci, Dept Biol, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Life Sci, FOUR KNU Creat BioRes Grp BK21, Daegu 41566, South Korea; ForBioKorea Co Ltd, Gasan Digital 2 Ro, Seoul 08504, South Korea; Univ Liverpool Liverpool Sch Trop Med, Dept Vector Biol, LIVERPOOL L3 5QA, England | ; Jeon, Jiseung/NRB-6964-2025 | 58673027200; 8847173600; 7102824979; 36602283400 | jiseung05181@gmail.com;mosqkim@gmail.com;martin.donnelly@lstmed.ac.uk;ksc@knu.ac.kr; | PARASITES & VECTORS | PARASITE VECTOR | 1756-3305 | 17 | 1 | SCIE | PARASITOLOGY;TROPICAL MEDICINE | 2024 | 3.5 | 5.4 | 0 | 2025-05-07 | 0 | 0 | Culex tritaeniorhynchus; Japanese encephalitis virus; Genetic diversity; Wolbachia; Republic of Korea | DIPTERA-CULICIDAE; IQ-TREE; MOSQUITOS; COI; TRANSMISSION; PHYLOGENY; COMPLEX | Culex tritaeniorhynchus; Genetic diversity; Japanese encephalitis virus; Republic of Korea; Wolbachia | Animals; Culex; Culex tritaeniorhynchus; DNA Barcoding, Taxonomic; Electron Transport Complex IV; Encephalitis Virus, Japanese; Encephalitis, Japanese; Genetic Variation; Mosquito Vectors; Phylogeny; Republic of Korea; Wolbachia; cytochrome c oxidase; animal experiment; Article; Culex tritaeniorhynchus; demographics; disease control; disease transmission; DNA extraction; encephalitis; female; gene sequence; gene structure; genetic variability; haplotype; Japanese encephalitis; Korea; nonhuman; phylogenetic tree; phylogeny; polymerase chain reaction; sequence analysis; vector borne disease; Wolbachia; animal; classification; Culex; Culex tritaeniorhynchus; DNA barcoding; epidemiology; genetic variation; genetics; isolation and purification; Japanese encephalitis; Japanese encephalitis virus group; microbiology; mosquito vector; South Korea; virology | English | 2024 | 2024-12-18 | 10.1186/s13071-024-06595-w | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Meeting Abstract | Microsatellite instability prediction model using the radiomics of F-18 fluorodeoxyglucose positron emission tomography/computed tomography in endometrial cancer | Kim, Jong Mi; Chong, Gun Oh; Lee, Yoon Hee; Yoon, Hee Yeun; Kim, Min Ju | Kyungpook Natl Univ, Gynecol Oncol, Chilgok Hosp, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Daegu, South Korea | INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER | INT J GYNECOL CANCER | 1048-891X | 1525-1438 | 34 | SUPPL_3 | SCIE | OBSTETRICS & GYNECOLOGY;ONCOLOGY | 2024 | 4.7 | 5.4 | 0 | English | 2024 | 2024-10 | 10.1136/ijgc-2024-igcs.90 | 바로가기 | 바로가기 | 바로가기 | ||||||||||||||
| ○ | ○ | Letter | Myelin Oligodendrocyte Glycoprotein Antibody-Positive Patients Meeting the 2017 McDonald Criteria for Multiple Sclerosis: Challenges in Diagnosis and Treatment Decisions | Kim, Sohyeon; Eun, Mi-Yeon; Lee, Jae-Joon; Seok, Hung Youl | Keimyung Univ, Dongsan Hosp, Sch Med, Dept Neurol, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Neurol, Daegu, South Korea; Keimyung Univ, Dongsan Hosp, Sch Med, Dept Neurol, 1035 Dalgubeol Daero, Daegu 42601, South Korea | Espejo, Carmen/E-5989-2018; Eun, Mi-Yeon/AAV-2877-2021; Seok, Hung Youl/HZI-4365-2023 | 57214724357; 36463396500; 57209362997; 24472118000 | shy2354@gmail.com; | ANNALS OF NEUROLOGY | ANN NEUROL | 0364-5134 | 1531-8249 | 95 | 2 | SCIE | CLINICAL NEUROLOGY;NEUROSCIENCES | 2024 | 7.7 | 5.4 | 2.26 | 2025-05-07 | 1 | 1 | Autoantibodies; Brain; Humans; Multiple Sclerosis; Myelin-Oligodendrocyte Glycoprotein; myelin oligodendrocyte glycoprotein antibody; oligoclonal band; protein antibody; unclassified drug; autoantibody; myelin oligodendrocyte glycoprotein; antibody titer; clinical feature; differential diagnosis; human; Letter; myelin oligodendrocyte glycoprotein antibody associated disease; myelooptic neuropathy; nuclear magnetic resonance imaging; phenotype; relapsing remitting multiple sclerosis; brain; multiple sclerosis | English | 2024 | 2024-02 | 10.1002/ana.26859 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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