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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Genetic characterization of third- or fourth-generation cephalosporin-resistant avian pathogenic Escherichia coli isolated from broilers | The third- or fourth-generation cephalosporins (3GC or 4 GC) are classified as "critically important antimicrobials for human medicine" by WHO, but resistance to these drugs is increasing rapidly in avian pathogenic E. coli (APEC). This study investigated the distribution and genetic characteristics of 3GC- or 4 GC-resistant APEC isolates from five major integrated broiler operations in Korea. The prevalence of 3GC- or 4GC-resistant APEC isolates in 1-week-old broilers was the highest in farms of operation C (53.3%); however, the highest prevalence of these isolates in 4-week-old broilers was the highest on the farms of operation A (60.0%), followed by operations E (50.0%) and C (35.7%). All 49 3GC- or 4GC-resistant APEC isolates had at least one beta-lactamase-encoding gene. The most common beta-lactamase-encoding genes was extended-spectrum beta-lactamase gene, bla(CTX-M-15), detected in 24 isolates (49.0%), followed by bla(TEM-1) (32.7%). Sixteen isolates (32.7%) harbored class 1 integrons, and four isolates (8.2%) showed different gene cassette-arrangements. However, only 1 of 26 isolates harboring class 2 integrons carried a gene cassette. Furthermore, both CRISPR 1 and 2 arrays were detected in most isolates (36 isolates; 73.5%), followed by CRISPR 2 (18.4%) and CRISPR 1 (4.1%). Interestingly, CRISPR 2 was significantly more prevalent in multidrug resistant (MDR)-APEC isolates than in non-MDR APEC isolates, whereas CRISPR 3 and 4 were significantly more prevalent in non-MDR APEC isolates (each 11.1%; p < 0.05). None of the protospacers of CRISPR arrays were directly associated with antimicrobial resistance. Our findings indicate that the distribution and characteristics of 3GC or 4GC-resistant APEC isolates differed among the integrated broiler operations; moreover, improved management protocols are needed to control the horizontal transmission of 3GC or 4GC-resistant APEC isolates. | Kang, Hyo Jung; Lim, Suk-Kyung; Lee, Young Ju | Kyungpook Natl Univ, Coll Vet Med, Daegu, South Korea; Kyungpook Natl Univ, Zoonoses Res Inst, Daegu, South Korea; Anim & Plant Quarantine Agcy, Bacterial Dis Div, Gimcheon, South Korea | 57224364605; 35086548900; 56612134500 | imsk0049@korea.kr;youngju@knu.ac.kr; | FRONTIERS IN VETERINARY SCIENCE | FRONT VET SCI | 2297-1769 | 9 | SCIE | VETERINARY SCIENCES | 2022 | 3.2 | 8.0 | 0.43 | 2025-06-25 | 2 | 2 | avian pathogenic E; coli; third-or fourth-generation cephalosporin resistance; genetic characteristics; CRISPR typing method; multidrug resistance (MDR) | SPECTRUM BETA-LACTAMASES; CLASS 1 INTEGRONS; MOLECULAR CHARACTERIZATION; ANTIMICROBIAL RESISTANCE; ANTIBIOTIC-RESISTANCE; FOOD ANIMALS; CRISPR; STRAINS; CHICKENS; DYNAMICS | avian pathogenic E. coli; CRISPR typing method; genetic characteristics; multidrug resistance (MDR); third-or fourth-generation cephalosporin resistance | amoxicillin plus clavulanic acid; ampicillin; beta lactamase CTX M; beta lactamase TEM 1; cefalotin; cefazolin; cefepime; cefotaxime; cefoxitin; ceftazidime; ceftiofur; cefuroxime; cephalosporin; chloramphenicol; ciprofloxacin; cotrimoxazole; extended spectrum beta lactamase; gentamicin; imipenem; nalidixic acid; tetracycline; agar dilution; agricultural land; antibiotic resistance; antibiotic sensitivity; Article; avian pathogenic Escherichia coli; bacterial transmission; bacteriophage; bacterium identification; bacterium isolation; broiler; cephalosporin resistance; class 1 integron; class 2 integron; clustered regularly interspaced short palindromic repeat; gene cassette; genetic trait; Korea; liver; minimum inhibitory concentration; multidrug resistance; nonhuman; plasmid; polymerase chain reaction; prevalence; sampling; sequence analysis; spleen | English | 2022 | 2022-11-25 | 10.3389/fvets.2022.1055320 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | How Well Are We Measuring Snow Post-SPICE? | Accurate snowfall measurements are necessary for meteorology, hydrology, and climate research. Typical uses include creating and calibrating gridded precipitation products, the verification of model simulations, driving hydrologic models, input into aircraft deicing processes, and estimating streamflow runoff in the spring. These applications are significantly impacted by errors in solid precipitation measurements. The recent WMO Solid Precipitation Intercomparison Experiment (SPICE) attempted to characterize and reduce some of the measurement uncertainties through an international effort involving 15 countries utilizing over 20 types and models of precipitation gauges from various manufacturers. Key results from WMO-SPICE are presented herein. Recent work and future research opportunities that build on the results of WMO-SPICE are also highlighted. | Kochendorfer, John; Earle, Michael; Rasmussen, Roy; Smith, Craig; Yang, Daqing; Morin, Samuel; Mekis, Eva; Buisan, Samuel; Roulet, Yves-Alain; Landolt, Scott; Wolff, Mareile; Hoover, Jeffery; Theriault, Julie M.; Lee, Gyuwon; Baker, Bruce; Nitu, Rodica; Lanza, Luca; Colli, Matteo; Meyers, Tilden | NOAA, Air Resources Lab, Atmospher Turbulence & Diffus Div, Oak Ridge, TN 37831 USA; Environm & Climate Change Canada, Meteorol Serv Canada, Dartmouth, NS, Canada; Natl Ctr Atmospher Res, POB 3000, Boulder, CO 80307 USA; Environm & Climate Change Canada, Climate Res Div, Saskatoon, SK, Canada; Environm & Climate Change Canada, Watershed Hydrol & Ecol Res Div, Victoria, BC, Canada; Univ Grenoble Alpes, Univ Toulouse, Ctr Etud Neige, CNRM,Meteo France,CNRS, Grenoble, France; Environm & Climate Change Canada, Climate Res Div, Toronto, ON, Canada; Agencia Estatal Meteorol, Aragon Reg Off, Zaragoza, Spain; MeteoSwiss, Payerne, Switzerland; Norwegian Meteorol Inst, As, Norway; Norwegian Univ Life Sci, As, Norway; Environm & Climate Change Canada, Meteorol Serv Canada, Toronto, ON, Canada; Univ Quebec Montreal, ESCER Ctr, Dept Earth & Atmospher Sci, Montreal, PQ, Canada; Kyungpook Natl Univ, Daegu, South Korea; Univ Genoa, Dept Civil Chem & Environm Engn, Genoa, Italy; WMO CIMO Lead Ctr B Castelli Precipitat Intens, Genoa, Italy; Artys Srl, Genoa, Italy | Morin, Samuel/E-8005-2011; Kochendorfer, John/K-2680-2012; Lanza, Luca/J-3427-2012 | 8284065800; 8373634800; 7201888941; 8429673100; 58116450500; 16043165000; 6603213257; 56515507800; 6507824209; 8697047600; 23568799600; 57197208562; 36343109300; 7404852271; 36824281400; 55307576800; 7005744799; 48161076500; 7004842448 | john.kochendorfer@noaa.gov; | BULLETIN OF THE AMERICAN METEOROLOGICAL SOCIETY | B AM METEOROL SOC | 0003-0007 | 1520-0477 | 103 | 2 | SCIE | METEOROLOGY & ATMOSPHERIC SCIENCES | 2022 | 8 | 8.0 | 3.96 | 2025-06-25 | 39 | 41 | Precipitation; Snowfall; Freezing precipitation; Hydrology; Instrumentation/sensors; Measurements | DAILY PRECIPITATION MEASUREMENTS; GAUGE COLLECTION EFFICIENCY; BIAS CORRECTION; CLIMATE-CHANGE; ENSEMBLE; ALPS; ACCUMULATION; UNCERTAINTY; SIMULATION; ADJUSTMENT | Freezing precipitation; Hydrology; Instrumentation/sensors; Measurements; Precipitation; Snowfall | Circuit simulation; Climate models; Hydrology; Snow; Aircraft deicing; Climate research; Freezing precipitations; Hydrologic models; Instrumentation/sensors; Intercomparisons; Model inputs; Modeling simulation; Precipitation products; Solid precipitation; Uncertainty analysis | English | 2022 | 2022-02 | 10.1175/bams-d-20-0228.1 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Jacobi forms over number fields from linear codes | We suggest a Jacobi form over a number field Q(root 5, i); for obtaining this, we use a linear code C over R := F-4 + uF(4), where u(2) = 0. We introduce MacWilliams identities for both complete weight enumerator and symmetrized weight enumerator in higher genus g >= 1 of a linear code over R. Finally, we give invariants via a self-dual code of even length over R. | Kim, Boran; Kim, Chang Heon; Kwon, Soonhak; Kwon, Yeong-Wook | Kyungpook Natl Univ, Dept Math Educ, Daehakro 80, Daegu 41566, South Korea; Sungkyunkwan Univ, Dept Math, Suwon 16419, South Korea; Ulsan Natl Inst Sci & Technol, Dept Math Sci, 50 UNIST Gil, Ulsan 44919, South Korea | 56909090000; 27168426400; 7402624473; 57207828175 | bkim21@knu.ac.kr; | AIMS MATHEMATICS | AIMS MATH | 2473-6988 | 7 | 5 | SCIE | MATHEMATICS, APPLIED;MATHEMATICS | 2022 | 2.2 | 8.0 | 0.25 | 2025-06-25 | 1 | 1 | Jacobi form; Frobenius ring; linear code; self-dual code; invariant | TOTALLY-REAL FIELDS; SELF-DUAL CODES; II CODES; WEIGHT ENUMERATORS; FINITE RINGS; LATTICES; Z(2M) | Frobenius ring; Invariant; Jacobi form; Linear code; Self-dual code | English | 2022 | 2022 | 10.3934/math.2022459 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Locally recoverable codes in Hermitian function fields with certain types of divisors | A locally recoverable code with locality r can recover the missing coordinate from at most r symbols. The locally recoverable codes have attracted a lot of attention because they are more advanced coding techniques that are applied to distributed and cloud storage systems. In this work, we focus on locally recoverable codes in Hermitian function fields over F-q2 where q is a prime power. With a certain type of divisor, we obtain an improved lower bound of the minimum distance for locally recoverable codes in Hermitian function fields. For doing this, we give explicit formulae of the dimension for some divisors of Hermitian function fields. We also present a standard that tells us when a divisor with certain places suggests an improved lower bound. | Kim, Boran | Kyungpook Natl Univ, Dept Math Educ, 80 Daehakro, Bukgu 41566, Daegu, South Korea | 56909090000 | bkim21@knu.ac.kr; | AIMS MATHEMATICS | AIMS MATH | 2473-6988 | 7 | 6 | SCIE | MATHEMATICS, APPLIED;MATHEMATICS | 2022 | 2.2 | 8.0 | 0 | 2025-06-25 | 0 | 0 | algebraic geometry LRC code; Hermitian function field | algebraic geometry LRC code; Hermitian function field | English | 2022 | 2022 | 10.3934/math.2022537 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Pathological and Genomic Findings of Erysipelothrix rhusiopathiae Isolated From a Free-Ranging Rough-Toothed Dolphin Steno bredanensis (Cetacea: Delphinidae) Stranded in Korea | Erysipelas, caused by Erysipelothrix rhusiopathiae, is considered one of the most serious infectious diseases of captive and free-ranging cetaceans worldwide, as these animals are known to be highly susceptible to the bacterial infections. The potential diversity between E. rhusiopathiae isolates from captive cetaceans has been previously described; however, the microbiological features of the free-ranging cetacean isolates remain unclear. Here, we describe a case of bacteremia in a rough-toothed dolphin (Steno bredanensis) caused by E. rhusiopathiae. Additionally, we present the first genomic features of the bacteria from free-ranging cetacean individuals. Histopathological and microbial examinations revealed that E. rhusiopathiae caused bacteremia and systemic infection in the dolphin. The genome of the isolated E. rhusiopathiae strain KC-Sb-R1, which was classified as Clade 1 possessing SpaB gene, was clearly differentiated from the other swine-isolated E. rhusiopathiae, and the comparison of its serovar-defining chromosomal region revealed that our isolate was greatly similar to those of other previously reported serovar 2/15 isolates, including the captive-dolphin isolate. Moreover, most of the potential virulence factors in the strain KC-Sb-R1 were similar to those in the strain Fujisawa. Further, a potential cytotoxicity of the isolate was confirmed, suggesting that marine mammal-isolated E. rhusiopathiae could possess strong pathogenic potential in other animals, including humans. These results would further increase our understanding on the risk factors for controlling zoonotic pathogens of emerging infectious diseases in captive or free-ranging cetaceans, and also provide important insight into the diversity of E. rhusiopathiae in animals. | Lee, Kyunglee; Park, Seon Young; Seo, Hwi Won; Cho, Yuna; Choi, Seok-Gwan; Seo, Seunghyun; Han, Wonmin; Lee, Nam-Kyung; Kwon, Hyemin; Han, Jee Eun; Kim, Ji Hyung | Natl Inst Fisheries Sci, Cetacean Res Inst, Ulsan, South Korea; Korea Res Inst Biosci & Biotechnol, Infect Dis Res Ctr, Daejeon, South Korea; Aquaplanet Co Ltd, Seoul, South Korea; Korea Res Inst Biosci & Biotechnol, Biotherapeut Translat Res Ctr, Daejeon, South Korea; Kyungpook Natl Univ, Coll Vet Med, Daegu, South Korea; Gachon Univ, Dept Food Sci & Biotechnol, Seongnam, South Korea | Kim, Ji Hyung/B-7321-2011 | 56305609800; 57208480038; 57209830672; 57202705850; 35738383700; 57208347967; 57208342264; 57191954466; 57219719164; 57214671240; 57225000204 | jehan@knu.ac.kr;kzh81@gachon.ac.kr; | FRONTIERS IN VETERINARY SCIENCE | FRONT VET SCI | 2297-1769 | 9 | SCIE | VETERINARY SCIENCES | 2022 | 3.2 | 8.0 | 1.3 | 2025-06-25 | 6 | 6 | Clade 1; free-ranging cetaceans; genome; serovar 2; 15; zoonotic pathogens | DNA-DNA HYBRIDIZATION; BOTTLE-NOSED-DOLPHIN; TURSIOPS-TRUNCATUS; SWINE ERYSIPELAS; SEPTICEMIA; IDENTIFICATION; STRAINS | Clade 1; free-ranging cetaceans; genome; serovar 2/15; zoonotic pathogens | animal experiment; animal tissue; Article; bacterial gene; bacterium isolation; Erysipelothrix infection; Erysipelothrix rhusiopathiae; genomics; histopathology; nonhuman; South Korea; spaB gene; Steno bredanensis; toothed whale | English | 2022 | 2022-05-06 | 10.3389/fvets.2022.774836 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Representations of modified type 2 degenerate poly-Bernoulli polynomials | Research on the degenerate versions of special polynomials provides a new area, introducing the lambda-analogue of special polynomials and numbers, such as lambda-Sheffer polynomials. In this paper, we propose a new variant of type 2 Bernoulli polynomials and numbers by modifying a generating function. Then we derive explicit expressions and their representations that provide connections among existing lambda-Sheffer polynomials. Also, we provide the explicit representations of the proposed polynomials in terms of the degenerate Lah-Bell polynomials and the higher-order degenerate derangement polynomials to confirm the presented identities. | Kwon, Jongkyum; Wongsason, Patcharee; Kim, Yunjae; Kim, Dojin | Gyeongsang Natl Univ, Dept Math Educ, Jinju 52828, South Korea; Ubon Ratchathani Univ, Fac Sci, Dept Math Stat & Comp, Ubon Ratchathani 34190, Thailand; Kyungpook Natl Univ, Dept Math, Daegu 41566, South Korea; Dongguk Univ, Dept Math, Seoul 04620, South Korea | Lee, Jun Young/CAI-2335-2022 | 55000770500; 57216978047; 57204477406; 57206696832 | kimdojin@dongguk.edu; | AIMS MATHEMATICS | AIMS MATH | 2473-6988 | 7 | 6 | SCIE | MATHEMATICS, APPLIED;MATHEMATICS | 2022 | 2.2 | 8.0 | 0.74 | 2025-06-25 | 3 | 3 | degenerate polyexponential functions; degenerate poly-Bernoulli polynomials; lambda-linear functionals; lambda-Sheffer sequences | degenerate poly-Bernoulli polynomials; degenerate polyexponential functions; λ-linear functionals; λ-Sheffer sequences | English | 2022 | 2022 | 10.3934/math.2022638 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Safety and immunogenicity of a SARS-CoV-2 recombinant protein nanoparticle vaccine (GBP510) adjuvanted with AS03: A randomised, placebo-controlled, observer-blinded phase 1/2 trial | Background Vaccination has helped to mitigate the COVID-19 pandemic. Ten traditional and novel vaccines have been listed by the World Health Organization for emergency use. Additional alternative approaches may better address ongoing vaccination globally, where there remains an inequity in vaccine distribution. GBP510 is a recombinant protein vaccine, which consists of self-assembling, two-component nanoparticles, displaying the receptor-binding domain (RBD) in a highly immunogenic array. Methods This randomised, placebo-controlled, observer-blinded phase 1/2 study was conducted to evaluate the safety and immunogenicity of GBP510 (2-doses at a 28-day interval) adjuvanted with or without AS03 in adults aged 19-85 years at 14 hospital sites in Korea. This study was consisted of two stages (stage I, healthy adults aged 19-55 years; stage II, 240 healthy adults aged 19-85 years). Healthy participants who did not previously receive any vaccine within 4 weeks (2 weeks for flu vaccine) prior to the study, no history of COVID-19 vaccination/medication, and were nayve to SARS-CoV-2 infection at screening were eligible for the study enrollment. Participants were block-randomized in a 2:2:1 ratio to receive 2 doses of 10 mu g GBP510 adjuvanted with AS03 (group 1), 10 mu g unadjuvanted GBP510 (group 2) or placebo intramuscularly in stage I, while they were block-randomized in a 2:2:1:1 ratio to receive 10 mu g GBP510 adjuvanted with AS03 (group 1), 25 mu g GBP510 adjuvanted with AS03 (group 3), 25 mu g unadjuvanted GBP510 (group 4) or placebo in stage II. The primary safety outcomes were solicited and unsolicited adverse events, while primary immunogenicity outcomes included anti-SARS-CoV-2 RBD IgG antibodies; neutralizing antibody responses; and T-cell immune responses. Safety assessment included all participants who received at least 1 dose of study intervention (safety set). Immunogenicity assessment included all participants who completed the vaccination schedule and had valid immunogenicity assessment results without any major protocol deviations (per-protocol set). This study was registered with ClinicalTrials.gov (NCT04750343). Findings Of 328 participants who were enrolled between February 1 and May 28, 2021, 327 participants received at least 1 dose of vaccine. Each received either 10 mu g GBP510 adjuvanted with AS03 (Group 1, n = 101), 10 mu g unadjuvanted GBP510 (Group 2, n = 10), 25 mu g GBP510 adjuvanted with AS03 (Group 3, n = 104), 25 mu g unadjuvanted GBP510 (Group 4, n = 51), or placebo (n = 61). Higher reactogenicity was observed in the GBP510 adjuvanted with AS03 groups compared to the non-adjuvanted and placebo groups. The most frequently reported solicited local adverse event (AE) was injection site pain after any vaccination: (88.1% in group 1; 50.0% in group 2; 92.3% in group 3; 66.7% in group 4). Fatigue and myalgia were two most frequently reported systemic AEs and more frequently reported in GBP510 adjuvanted with AS03 recipients (79.2% and 78.2% in group 1; 75.0% and 79.8% in group 3, respectively) than in the unadjuvanted vaccine recipients (40.0% and of 40.0% in group 2; 60.8% and 47.1% in group 4) after any vaccination. Reactogenicity was higher post-dose 2 compared to post-dose 1, particularly for systemic AEs. The geometric mean concentrations of anti-SARS-CoV-2-RBD IgG antibody reached 2163.6/2599.2 BAU/mL in GBP510 adjuvanted with AS03 recipients (10 mu g/25 mu g) by 14 days after the second dose. Two-dose vaccination of 10 mu g or 25 mu g GBP510 adjuvanted with AS03 induced high titres of neutralizing antibody via pseudovirus (1369.0/1431.5 IU/mL) and wild-type virus (949.8/861.0 IU/mL) assay. Interpretation GBP510 adjuvanted with AS03 was well tolerated and highly immunogenic. These results support further development of the vaccine candidate, which is currently being evaluated in Phase 3. Copyright (C) 2022 Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/) | Song, Joon Young; Choi, Won Suk; Heo, Jung Yeon; Lee, Jin Soo; Jung, Dong Sik; Kim, Shin-Woo; Park, Kyung-Hwa; Eom, Joong Sik; Jeong, Su Jin; Lee, Jacob; Kwon, Ki Tae; Choi, Hee Jung; Sohn, Jang Wook; Kim, Young Keun; Noh, Ji Yun; Kim, Woo Joo; Roman, Francois; Ceregido, Maria Angeles; Solmi, Francesca; Philippot, Agathe; Walls, Alexandra C.; Carter, Lauren; Veesler, David; King, Neil P.; Kim, Hun; Ryu, Ji Hwa; Lee, Su Jeen; Park, Yong Wook; Park, Ho Keun; Cheong, Hee Jin | Korea Univ, Coll Med, Dept Internal Med, Div Infect Dis,Guro Hosp, Gurodong Ro 148, Seoul 08308, South Korea; Korea Univ, Coll Med, Dept Internal Med, Div Infect Dis,Ansan Hosp, Ansan, South Korea; Ajou Univ, Dept Infect Dis, Sch Med, Suwon, South Korea; Inha Univ, Dept Internal Med, Div Infect Dis, Coll Med, Incheon, South Korea; Dong A Univ, Div Infect Dis, Dept Internal Med, Coll Med, Busan, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Chonnam Natl Univ, Dept Internal Med, Div Infect Dis, Med Sch, Gwangju, South Korea; Gachon Univ, Gil Med Ctr, Dept Internal Med, Div Infect Dis,Coll Med, Incheon, South Korea; Yonsei Univ, Severance Hosp, Dept Internal Med, Div Infect Dis,Coll Med, Seoul, South Korea; Hallym Univ, Dept Internal Med, Div Infect Dis, Coll Med, Chunchon, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Ewha Womans Univ, Dept Internal Med, Div Infect Dis, Mokdong Hosp, Seoul, South Korea; Korea Univ, Coll Med, Dept Internal Med, Div Infect Dis,Anam Hosp, Seoul, South Korea; Yonsei Univ, Wonju Coll Med, Dept Internal Med, Div Infect Dis,Wonju Severance Christian Hosp, Wonju, South Korea; GlaxoSmithKline Vaccines, Wavre, Belgium; Univ Washington, Dept Biochem, Seattle, WA 98195 USA; Univ Washington, Howard Hughes Med Inst, Seattle, WA 98195 USA; Univ Washington, Inst Prot Design, Seattle, WA 98195 USA; SK Biosci, Dept R&S, Seongnam, South Korea | ; Jung, Dong Sik/HOH-5826-2023; Park, MK/GVU-0647-2022; Park, Mi-Kyung/J-9643-2017; Choi, Won Suk/V-2730-2017; Veesler, David/HCH-3986-2022; Kim, Young/H-4235-2013; Hwang, Soyoon/HHM-5762-2022; Choi, Won/V-2730-2017; Kim, Woo/D-2733-2015; Kim, Ik-Sang/J-5425-2012; Kim, Hyunho/GQH-5608-2022 | 57214400146; 56718971800; 24587525000; 56162297100; 14023089600; 57189703358; 57219637574; 8312280800; 57226001028; 13406664300; 9733850500; 57217262202; 7201641941; 35322538300; 24587375200; 27171770800; 35095682000; 55757967800; 57728627000; 57728202800; 57159082300; 57150098700; 25227836200; 21734768100; 56181024800; 57202189550; 57215716638; 59844812200; 57433258200; 7102495865 | heejinmd@korea.ac.kr; | ECLINICALMEDICINE | ECLINICALMEDICINE | 2589-5370 | 51 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 15.1 | 8.0 | 10.36 | 2025-06-25 | 67 | 65 | SARS-CoV-2; COVID-19; Recombinant protein vaccine; Nanoparticle vaccine; Humoral immunity; Cellular immunity | RECEPTOR-BINDING-DOMAIN; ELICITATION; RESPONSES | Cellular immunity; COVID-19; Humoral immunity; Nanoparticle vaccine; Recombinant protein vaccine; SARS-CoV-2 | as 03; immunoglobulin G antibody; neutralizing antibody; placebo; skycovione; triacylglycerol; unclassified drug; vaccine adjuvant; adult; aged; antibody response; Article; cellular immunity; clinical feature; clinical outcome; cohort analysis; controlled study; drug formulation; drug safety; drug screening; drug tolerability; fatigue; female; headache; human; human cell; injection site pain; injection site swelling; intervention study; Korea; male; myalgia; nonhuman; observational study; phase 1 clinical trial; phase 2 clinical trial; randomized controlled trial; side effect; skin redness; treatment duration; triacylglycerol blood level; vaccine immunogenicity | English | 2022 | 2022-09 | 10.1016/j.eclinm.2022.101569 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | A remarkable adsorbent for denitrogenation of liquid fuel: Ethylenediaminetetraacetic acid-grafted metal-organic framework, MOF-808 | Removal of nitrogen-containing compounds (NCCs) from the fuel is essential for clean energy. An efficient adsorbent with ample active sites was obtained via grafting ethylenediaminetetraacetic acid (EDTA) onto a metal-organic framework (MOF808). The obtained MOF808EDTA was firstly applied in adsorptive removal of organics like NCCs from liquid; showed remarkable performances in NCCs removal. For example, MOF808EDTA showed the maximum adsorption capacity (Q(0)) of 667 and 625 mg/g, respectively, in indole (IND) and quinoline (QUIN) removal from fuel. These Q(0) values for QUIN and IND adsorption are the highest and third position, respectively, compared with reported results. Additionally, the Q(0) values for IND and QUIN are > 10 times those of activated carbon. Importantly, the Q(0) value, in volume/weight (0.57 cm(3)/g), is very close to the total pore volume (0.59 cm(3)/g) of MOF808EDTA, suggesting very effective utilization of pores of the MOF in the adsorption. The adsorption of IND and QUIN over MOF808EDTA could be interpreted with H-bonding and acid base interactions, respectively, based on properties of adsorbates and functional groups on MOF808EDTA and MOF808EDTA-Na (where hydrogen in EDTA was replaced with Na). The new adsorbent MOF808EDTA, which is highly reusable, is being suggested as a prominent adsorbent to remove NCCs, especially basic QUIN, from fuel. This work will pave the way to modify MOFs to introduce ample functional groups that will be effective in | Mondol, Md Mahmudul Hassan; Park, Jong Min; Jhung, Sung Hwa | Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Kyungpook Natl Univ, Green Nano Mat Res Ctr, Daegu 41566, South Korea | Jhung, Sung/AAO-6683-2021; Hassan Mondol, Md Mahmudul/AAM-8718-2021 | 57217989090; 57193995796; 6701659467 | sung@knu.ac.kr; | SEPARATION AND PURIFICATION TECHNOLOGY | SEP PURIF TECHNOL | 1383-5866 | 1873-3794 | 284 | SCIE | ENGINEERING, CHEMICAL | 2022 | 8.6 | 8.1 | 1.22 | 2025-06-25 | 21 | 20 | Adsorptive denitrogenation; Ethylenediaminetetraacetic acid; Indole; Grafting; MOF808; Quinoline | NITROGEN-CONTAINING COMPOUNDS; DOPED POROUS CARBONS; ADSORPTIVE DENITROGENATION; MODEL FUEL; FUNCTIONAL-GROUPS; BASE INTERACTIONS; MSU-S; REMOVAL; DESULFURIZATION; QUINOLINE | Adsorptive denitrogenation; Ethylenediaminetetraacetic acid; Grafting; Indole; MOF808; Quinoline | Activated carbon; Adsorption; Ethylenediaminetetraacetic acid; Fuels; Nitrogen removal; Polycyclic aromatic hydrocarbons; Active site; Adsorptive denitrogenation; Adsorptive removal; Clean energy; Denitrogenation; Metalorganic frameworks (MOFs); Mof808; Organics; Performance; Quinoline; Grafting (chemical) | English | 2022 | 2022-02-01 | 10.1016/j.seppur.2021.120248 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Boron nitride-based nanomaterials as adsorbents in water: A review | Various physical shapes of boron nitride (BN)-based nanoadsorbents such as nanoparticles, fullerenes, nanotubes, nanofibers, nanoribbons, nanosheets, nanomeshes, nanoflowers, and hollow spheres have been broadly considered possible adsorbents owing to their exceptional characteristics such as large surface area, structural variability, great chemical/mechanical strength, abundant structural defects, high reactive sites, and functional groups. In general, adsorption mechanisms vary primarily depending on the characteristics/properties of contaminants/adsorbents and solution chemistry/conditions. Therefore, complete knowledge of the adsorptive performance of BN-based nanomaterials is essential to clarify how they eliminate inorganic and organic contaminants in aqueous solution. This review evaluates the latest broad studies on the adsorption of different inorganic (heavy metals) and organic contaminants (primarily dyes and pharmaceuticals) using BN-based nanomaterials and correspondingly summarizes helpful information for using these nanomaterials in water and wastewater treatment. In addition, recent challenges and potential study requirements for the adsorption of contaminants using BN-based nanomaterials in water treatment activities are considered in brief. | Park, Yong-Gyun; Nam, Seong-Nam; Jang, Min; Park, Chang Min; Her, Namguk; Sohn, Jinsik; Cho, Jaeweon; Yoon, Yeomin | Chonnam Natl Univ, Dept Environm & Energy Engn, Gwangju 61186, South Korea; Korea Army Acad Yeong Cheon, Dept Civil & Environm Engn, Kokyungmeon, Yeong Cheon, 495 Hoguk Ro,Kokyungmeon, Yeong Cheo 38900, Gyeongbuk, South Korea; Univ South Carolina, Dept Civil & Environm Engn, 300 Main St, Columbia, SC 29208 USA; Kwangwoon Univ, Dept Environm Engn, 447-1 Wolgye Dong Nowon, Seoul 01897, South Korea; Kyungpook Natl Univ, Dept Environm Engn, 80 Daehak-ro, Buk Gu, Daegu, South Korea; Int Environm Res Inst, Gwangju Inst Sci & Technol GIST, 123 Cheomdangwagi Ro,Buk Gu, Gwangju 61005, South Korea; Kookmin Univ, Sch Civil & Environm Engn, Seoul 02707, South Korea; Ulsan Natl Inst Sci & Technol, Dept Urban & Environm Engn, UNIST Gil 50,Ulju Gun, Ulsan 44919, South Korea | Nam, Seong-Nam/ABT-9415-2022; Park, Chang Min/CAA-8506-2022; Jang, Min/M-6690-2018; Jang, Min/J-2230-2012; Yoon, Yeomin/KDP-2253-2024 | 39262310200; 57226757907; 36762550700; 57209588953; 6701721727; 7201642033; 7403536101; 7402126688 | yoony@cec.sc.edu; | SEPARATION AND PURIFICATION TECHNOLOGY | SEP PURIF TECHNOL | 1383-5866 | 1873-3794 | 288 | SCIE | ENGINEERING, CHEMICAL | 2022 | 8.6 | 8.1 | 1.16 | 2025-06-25 | 35 | 39 | Adsorption; Boron nitride-based nanomaterials; Heavy metal; Organic Contaminants; Water; Wastewater treatment | HIGHLY EFFICIENT ADSORBENT; STRAW-DERIVED BIOCHAR; AQUEOUS-SOLUTIONS; METHYLENE-BLUE; ADSORPTION PERFORMANCE; CARBON NANOTUBES; EXCELLENT PERFORMANCE; SUPERIOR ADSORBENTS; ARSENIC ADSORPTION; EFFECTIVE REMOVAL | Adsorption; Boron nitride-based nanomaterials; Heavy metal; Organic Contaminants; Water/Wastewater treatment | Boron nitride; Chemicals removal (water treatment); Contamination; Heavy metals; III-V semiconductors; Nanosheets; Nanostructured materials; Nitrides; Organometallics; Wastewater treatment; Boron nitride-based nanomaterial; Fullerene nanotubes; Hollow sphere; Large surface area; Nanoadsorbents; Nanomesh; Nanoparticle spheres; Organic contaminant; Structural variability; Water/wastewater treatment; Adsorption | English | 2022 | 2022-05-01 | 10.1016/j.seppur.2022.120637 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Impact of HBeAg on Hepatocellular Carcinoma Risk During Oral Antiviral Treatment in Patients With Chronic Hepatitis B | BACKGROUND & AIMS: Antiviral treatment from hepatitis B envelope antigen (HBeAg)-positive status may attenuate the integration of hepatitis B virus DNA into the host genome causing hepatocellular carcinoma (HCC). We investigated the impact of HBeAg status at the onset of antiviral treatment on the risk of HCC. METHODS: The incidence of HCC was evaluated in Korean patients with chronic hepatitis B who started entecavir or tenofovir in either HBeAg-positive or HBeAg-negative phase. The results in the Korean cohort were validated in a Caucasian PAGE-B cohort. RESULTS: A total of 9143 Korean patients (mean age, 49.2 years) were included: 49.1% were HBeAg-positive and 49.2% had cirrhosis. During follow-up (median, 5.1 years), 916 patients (10.0%) developed HCC. Baseline HBeAg positivity was not associated with the risk of HCC in the entire cohort or cirrhotic subcohort. However, in the non-cirrhotic subcohort, HBeAg positivity was independently associated with a lower risk of HCC in multivariable (adjusted hazard ratio [aHR], 0.41; 95% confidence interval [CI], 0.26-0.66), propensity score-matching (aHR, 0.46; 95% CI, 0.28-0.76), and inverse probability weighting analyses (aHR, 0.44; 95% CI, 0.28-0.70). In the Caucasian cohort (n = 719; mean age, 51.8 years; HBeAg-positive, 20.3%; cirrhosis, 34.8%), HBeAg-positivity was not associated with the risk of HCC either in the entire cohort or cirrhotic subcohort. In the non-cirrhotic subcohort, none of the HBeAg-positive group developed HCC, although the difference failed to reach statistical significance (aHR, 0.21; 95% CI, 0.00-1.67). CONCLUSIONS: This multinational cohort study implies that HBeAg positivity at the onset of antiviral treatment seems to be an independent factor associated with a lower risk of HCC in patients with chronic hepatitis B without cirrhosis, but not in those with cirrhosis. | Jang, Heejoon; Yoon, Jun Sik; Park, Soo Young; Lee, Han Ah; Jang, Myoung-Jin; Kim, Seung Up; Sinn, Dong Hyun; Seo, Yeon Seok; Kim, Hwi Young; Kim, Sung Eun; Jun, Dae Won; Yoon, Eileen L.; Sohn, Joo Hyun; Ahn, Sang Bong; Shim, Jae-Jun; Jeong, Soung Won; Cho, Yong Kyun; Kim, Hyoung Su; Nam, Joon Yeul; Lee, Yun Bin; Kim, Yoon Jun; Yoon, Jung-Hwan; Zoulim, Fabien; Lampertico, Pietro; Dalekos, George N.; Idilman, Ramazan; Sypsa, Vana; Berg, Thomas; Buti, Maria; Calleja, Jose Luis; Goulis, John; Manolakopoulos, Spilios; La Janssen, Harry; Papatheodoridis, George, V; Lee, Jeong-Hoon | Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Seoul Natl Univ, Coll Med, Liver Res Inst, Seoul, South Korea; Seoul Natl Univ, Boramae Med Ctr, Dept Internal Med, Seoul Metropolitan Govt, Seoul, South Korea; Inje Univ, Busan Paik Hosp, Dept Internal Med, Coll Med, Busan, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Korea Univ, Anam Hosp, Coll Med, Dept Internal Med, Seoul, South Korea; Inje Univ, Sanggye Paik Hosp, Coll Med, Dept Internal Med, Seoul, South Korea; Seoul Natl Univ Hosp, Med Res Collaborat Ctr, Seoul, South Korea; Yonsei Univ, Severance Hosp, Coll Med, Dept Internal Med, Seoul, South Korea; Yonsei Univ, Severance Hosp, Coll Med, Yonsei Liver Ctr, Seoul, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Internal Med, Seoul, South Korea; Ewha Womans Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Hallym Univ, Hallym Univ Sacred Heart Hosp, Coll Med, Dept Internal Med, Anyang Si, South Korea; Hanyang Univ, Hanyang Univ Hosp, Coll Med, Dept Internal Med, Seoul, South Korea; Hanyang Univ, Guri Hosp, Coll Med, Dept Internal Med, Guri Si, South Korea; Eulji Univ, Coll Med, Nowon Eulji Med Ctr, Dept Internal Med, Seoul, South Korea; Kyung Hee Univ, Sch Med, Dept Internal Med, Seoul, South Korea; Soonchunhyang Univ, Soonchunhyang Univ Seoul Hosp, Dept Internal Med, Coll Med, Seoul, South Korea; Sungkyunkwan Univ, Kangbuk Samsung Hosp, Sch Med, Dept Internal Med, Seoul, South Korea; Hallym Univ, Kangdong Sacred Heart Hosp, Coll Med, Dept Internal Med, Seoul, South Korea; Lyon Univ, Hosp Civils Lyon, Canc Res Ctr Lyon, INSERM U, Lyon, France; Fdn IRCCS Ca Granda Osped Maggiore Policlin, Div Gastroenterol & Hepatol, Milan, Italy; Univ Milan, CRC AM & A Migliavacca Ctr Liver Dis, Dept Pathophysiol & Transplantat, Milan, Italy; Gen Univ Hosp Larissa, Natl Expertise Ctr Greece Autoimmune Liver Dis, Dept Med, Larisa, Greece; Gen Univ Hosp Larissa, Natl Expertise Ctr Greece Autoimmune Liver Dis, Res Lab Internal Med, Larisa, Greece; Ankara Univ, Dept Gastroenterol, Sch Med, Ankara, Turkey; Natl & Kapodistrian Univ Athens, Dept Hyg Epidemiol & Med Stat, Med Sch, Athens, Greece; Univ Leipzig, Dept Med 2, Div Hepatol, Med Ctr, Leipzig, Germany; Hosp Gen Univ Vall Hebron, Barcelona, Spain; Ciberehd, Barcelona, Spain; Hosp U Puerta de Hierro, IDIPHIM CIBERehd, Madrid, Spain; Ristotle Univ Thessaloniki, Gen Hosp Thessaloniki Hippokratio, Dept Internal Med, Med Sch, Thessaloniki, Greece; Natl & Kapodistrian Univ Athens, Gen Hosp Athens Hippokratio, Dept Internal Med 2, Med Sch, Athens, Greece; Univ Hlth Network, Toronto Western & Gen Hosp, Liver Clin, Toronto, ON, Canada; Natl & Kapodistrian Univ Athens, Gen Hosp Athens Laiko, Dept Gastroenterol, Med Sch, Athens, Greece | Panero, Jose/A-5351-2010; SYPSA, VANA/A-5082-2008; Kim, Yoon/J-2746-2012; Buti, MARIA/A-5327-2019; Kim, Joo/X-7562-2019; Kim, Cheol-Hee/F-6278-2013; Kim, Donghee/C-4288-2013; Sinn, Dong/JAC-4247-2023; Manolakopoulos, Spilios/AAD-7058-2019; Lampertico, Pietro/J-8463-2018; Kim, Sun/L-4239-2013; Lee, Jeong-Hoon/Q-1055-2018; Idilman, Ramazan/AFL-0461-2022; Yoon, Jung/J-5563-2012; Papatheodoridis, George/A-4603-2008; Lee, Hyun Woo/AAH-8473-2020; Lee, Yoojin/AAB-9799-2022; Jun, Dae Won/O-4529-2017 | 57197796643; 57195953972; 57191674344; 57190980926; 55317673900; 54933821200; 23493891100; 35234912400; 56493773500; 57189074365; 8662222500; 35338420100; 14621705600; 57224800099; 35273672400; 55625009600; 35261851400; 7410129808; 57193006895; 55917845400; 25947520600; 16246591600; 7006912131; 7006770607; 7006547284; 7003986090; 6603369653; 15833772800; 7007153523; 7102111355; 6603115432; 6602688592; 56489785600; 7003883848; 55936232200 | pindra@empal.com;gepapath@med.uoa.gr; | CLINICAL GASTROENTEROLOGY AND HEPATOLOGY | CLIN GASTROENTEROL H | 1542-3565 | 1542-7714 | 20 | 6 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2022 | 12.6 | 8.1 | 0.78 | 2025-06-25 | 10 | 9 | Cumulative Incidence; DNA; Hepatitis B Virus; Liver Cancer; Neoplasm | TRANSIENT ELASTOGRAPHY; LIVER; DNA; INTEGRATION; PREDICTION; VALIDATION; INFECTION; EXPANSION; FIBROSIS; THERAPY | Cumulative Incidence; DNA; Hepatitis B Virus; Liver Cancer; Neoplasm | Antiviral Agents; Carcinoma, Hepatocellular; Cohort Studies; Hepatitis B Antigens; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver Cirrhosis; Liver Neoplasms; Middle Aged; entecavir; hepatitis B(e) antigen; tenofovir disoproxil; antivirus agent; hepatitis B surface antigen; hepatitis B(e) antigen; adult; antiviral therapy; Article; cancer risk; Caucasian; chronic hepatitis B; cohort analysis; disease association; drug effect; female; follow up; hazard ratio; human; liver cell carcinoma; liver cirrhosis; major clinical study; male; risk assessment; complication; genetics; Hepatitis B virus; liver cell carcinoma; liver cirrhosis; liver tumor; middle aged | English | 2022 | 2022-06 | 10.1016/j.cgh.2021.09.001 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Predictive Performance of CAGE-B and SAGE-B Models in Asian Treatment-Naive Patients Who Started Entecavir for Chronic Hepatitis B | BACKGROUND & AIMS: Cirrhosis and age (CAGE-B) and stiffness and age (SAGE-B) models assess the risk of hepatocellular carcinoma (HCC) development in white patients with chronic hepatitis B (CHB) undergoing sustained antiviral therapy (AVT). Herein, we checked the predictive performance of these models in Asian patients with CHB. METHODS: We reviewed 734 treatment-naive patients with CHB who started entecavir between 2006 and 2011 and were followed up for more than 5 years without HCC development during AVT. The predictive performance of CAGE-B and SAGE-B models was calculated using area under the receiver operating characteristic curves (AUROCs). RESULTS: Median liver stiffness assessed using transient elastography after 5 years of AVT was 6.8 kPa. Median CAGE-B and SAGE-B models after 5 years of AVT were 7.0 and 6.0, respectively. More than 5 years after AVT initiation, 66 patients (9.0%) developed HCC. The AUROCs of the CAGE-B and SAGE-B models were 0.764 and 0.785 after 7 years and 0.799 and 0.802 after 10 years of AVT, respectively. The cumulative incidence of HCC was significantly higher in the high-risk groups according to CAGE-B and SAGE-B risk stratification than in the medium- and low-risk groups (P < .05 in all cases). The SAGE-B model showed a higher likelihood ratio (chi(2)) (76.2 vs 71.4) and linear trend (chi(2)) (74.1 vs 58.6) than the CAGE-B model, whereas the CAGE-B model showed higher Akaike information criteria (64.3 vs 50.3). CONCLUSIONS: Both SAGE-B and CAGE-B showed acceptable performance in predicting HCC after 5 years of AVT in Asian patients with CHB. | Chon, Hye Yeon; Lee, Jae Seung; Lee, Hye Won; Chun, Ho Soo; Kim, Beom Kyung; Tak, Won Young; Park, Jun Yong; Kweon, Young-Oh; Kim, Do Young; Ahn, Sang Hoon; Jang, Se Young; Park, Soo Young; Kim, Seung Up | Yonsei Univ, Dept Internal Med, Coll Med, Yonsei Ro 50-1, Seoul, South Korea; Yonsei Univ, Inst Gastroenterol, Coll Med, Seoul, South Korea; Severance Hosp, Yonsei Liver Ctr, Seoul, South Korea; Kyungpook Natl Univ Hosp, Dept Internal Med, 130 Dongdeok Ro, Daegu 41944, South Korea | ; Ahn, Sang Hoon/AFM-2603-2022; Kim, Sun/L-4239-2013; Kim, Jin Hyoung/AAE-8050-2019; Kim, Nayoung/J-5387-2012; LEE, JAE SEUNG/KHT-9575-2024; Park, Jun/H-7127-2019; SANG-HOON, AHN/AAV-2600-2020; Kim, Dong/F-4608-2014; Lee, Hye/D-9081-2016 | 57221761823; 57204060462; 57200110315; 57215293394; 35302925200; 7004074582; 47861376300; 7004694832; 56119929100; 7401989551; 57202881977; 57191674344; 54933821200 | psyoung0419@gmail.com;ksukorea@yuhs.ac; | CLINICAL GASTROENTEROLOGY AND HEPATOLOGY | CLIN GASTROENTEROL H | 1542-3565 | 1542-7714 | 20 | 4 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2022 | 12.6 | 8.1 | 1.13 | 2025-06-25 | 13 | 13 | Risk Prediction Model; Hepatocellular Carcinoma; Chronic Hepatitis B; CAGE-B; SAGE-B | DEVELOPING HEPATOCELLULAR-CARCINOMA; TRANSIENT ELASTOGRAPHY; ANTIVIRAL THERAPY; RISK; CAUCASIANS; MANAGEMENT; PROGRAM; CANCER | CAGE-B; Chronic Hepatitis B; Hepatocellular Carcinoma; Risk Prediction Model; SAGE-B | Antiviral Agents; Carcinoma, Hepatocellular; Guanine; Hepatitis B, Chronic; Humans; Liver Cirrhosis; Liver Neoplasms; entecavir; antivirus agent; entecavir; guanine; adult; antiviral therapy; area under the curve; Article; cancer incidence; chronic hepatitis B; clinical feature; cohort analysis; controlled study; diagnostic accuracy; diagnostic test accuracy study; disease association; disease course; disease duration; elastography; female; follow up; high risk patient; human; liver cell carcinoma; liver cirrhosis; liver stiffness; major clinical study; male; predictive value; receiver operating characteristic; retrospective study; risk assessment; scoring system; treatment duration; complication; liver cell carcinoma; liver cirrhosis; liver tumor; pathology | English | 2022 | 2022-04 | 10.1016/j.cgh.2021.06.001 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Forecasting COVID-19 cases by assessing control-intervention effects in Republic of Korea: A statistical modeling approach | The Coronavirus disease of 2019 (COVID-19) is an ongoing public health concern worldwide. COVID-19 infections continue to occur and thus, it is important to assess the effects of various public health measures. This study aims to forecast COVID-19 cases by geographical area in Korea, based on the effects of different control-intervention intensities (CII). Methods involved estimating the effective reproduction number (Rt) by Korean geographical area using the SEIHR model, and the instantaneous reproduction number using statistical model, comparing the epidemic curves and high-, intermediate-, and low-intensity control interventions. Here, shortterm four-week forecasts by geographical area were conducted. The mean of delayed instantaneous reproduction number was estimated at 1.36, 1.03, and 0.93 for the low-, intermediate-, and high intensity control interventions, respectively, in the capital area of Korea from July 16, 2020, to March 4, 2021. The COVID-19 cases were forecasted with an accuracy rate of 11.28%, 13.62%, and 20.19% MAPE in Korea, including both the capital and non-capital areas. High-intensity control measures significantly reduced the reproduction number to be less than one. The proposed model forecasted COVID-19 transmission dynamics with good accuracy and interpretability. High-intensity control intervention, active case detection, and isolation efforts should be maintained to control the pandemic. (c) 2022 THE AUTHORS. Published by Elsevier BV on behalf of Faculty of Engineering, Alexandria University. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/ 4.0/). | Lee, Hyojung; Jang, Geunsoo; Cho, Giphil | Kyungpook Natl Univ, Dept Stat, Daegu 41566, South Korea; Pusan Natl Univ, Dept Math, Busan 46241, South Korea; Pusan Natl Univ, Finance Fishery Manufacture Ind Math Ctr Big Data, Busan 46241, South Korea | 57196021198; 57471384400; 56665111500 | giphil@pusan.ac.kr; | ALEXANDRIA ENGINEERING JOURNAL | ALEX ENG J | 1110-0168 | 2090-2670 | 61 | 11 | SCIE | ENGINEERING, MULTIDISCIPLINARY | 2022 | 6.8 | 8.3 | 0.74 | 2025-06-25 | 7 | 7 | COVID-19; Transmission dynamics; Mathematical models; Forecasting; Reproduction number; Control intervention | Control intervention; COVID-19; Forecasting; Mathematical models; Reproduction number; Transmission dynamics | Cell proliferation; Disease control; Estimation; Forecasting; Public health; Transmissions; Control intervention; Coronavirus disease of 2019; Coronaviruses; Geographical area; High intensity; Modeling approach; Reproduction numbers; Republic of Korea; Statistic modeling; Transmission dynamics; Coronavirus | English | 2022 | 2022-11 | 10.1016/j.aej.2022.02.037 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Short-term electric load prediction using transfer learning with interval estimate adjustment | Although we are currently in the era of big data, it is always challenging to obtain complete and largescale data due to the information protection for users and enterprises. In most cases, only partial data can be obtained, which harms the machine learning-based prediction model's performance. To effectively improve load forecasting accuracy, we propose a CNN-GRU hybrid model with parameter-based transfer learning. By transferring the training model details from a model with an extensive dataset to another model trained with a smaller dataset, the performance and accuracy of a prediction model with a smaller dataset can be improved. After that, we use the solve-the-equation (STE) method to estimate the bandwidth of data distribution by minimizing the mean integrated square error (MISE), this will in conjunction with prediction results provides a load prediction interval, which can provide the future load curve's fluctuation range at a specific confidence interval (CI). To verify the proposed method's effectiveness, we use residential data from the United States and commercial data from South Korea for predictive analysis. The experimental results show that the load forecast method with interval estimate adjustment proposed in this paper can effectively improve the accuracy and reliability of load forecasting under the scarcity of data. (c) 2022 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | Jin, Yuwei; Acquah, Moses Amoasi; Seo, Mingyu; Han, Sekyung | Kyungpook Natl Univ, Elect & Elect Engn, Daegu 41566, South Korea; Keimyung Univ, Elect Energy Engn, Daegu 42601, South Korea | Jin, Yuwei/LIR-2747-2024 | 57212253293; 57105816500; 57215358477; 36023785800 | jinyuwei91@gmail.com;amoasiacquah@kmu.ac.kr;skhan@knu.ac.kr; | ENERGY AND BUILDINGS | ENERG BUILDINGS | 0378-7788 | 1872-6178 | 258 | SCIE | CONSTRUCTION & BUILDING TECHNOLOGY;ENERGY & FUELS;ENGINEERING, CIVIL | 2022 | 6.7 | 8.3 | 2.75 | 2025-06-25 | 25 | 35 | Load forecast; CNN-GRU hybrid model; Transfer learning; Confidence interval | CNN-GRU hybrid model; Confidence interval; Load forecast; Transfer learning | Electric power plant loads; Learning systems; CNN-GRU hybrid model; Confidence interval; Hybrid model; Interval estimate; Load forecast; Load forecasting; Prediction modelling; Short term electric load; Small data set; Transfer learning; Forecasting | English | 2022 | 2022-03-01 | 10.1016/j.enbuild.2022.111846 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Effect of multihole baffle-induced lobe flow structures on a high efficiency micro-thermophotovoltaic system | For a combustion-based thermophotovoltaic generator (TPV), the baffle-induced reacting flows are numerically investigated in the micro combustor with a multihole baffle representing a mixed feature of bluff body and multiple jets. The lobed flow feature is realized by the momentum difference between fuel and air streams and the baffle wall, not the geometrical conditions like a lobed nozzle. Compared with the H-2-air combustor, the lobed flame and the votical structure are enhanced for the CH4-air combustor. To analyze the lobed structure, the lobe intensity and the equivalent perimeter are defined for the stoichiometric mixture line. The maximum lobe intensity is observed at the beginning zone of flame, whereas the equivalent perimeter is increased near the active reaction zone. As the baffle thickness decreases, the lobe structure is enhanced due to the increased vortices. Also, a close relationship between the maximum vorticities at the baffle exit and the maximized lobe structure is observed. The intensified lobe structure contributes to a shorter flame length and more efficient combustion, resulting in increased radiation available for a micro-TPV system. When the lobe structure is enhanced, the high emitter efficiency for an energy conversion device is obtained as 0.319-0.326 for the H-2-air combustor. | Kim, Won Hyun; Park, Tae Seon | Kyungpook Natl Univ, Sch Mech Engn, Daegu, South Korea | 55360608000; 7401801892 | tsparkjp@knu.ac.kr; | ENGINEERING APPLICATIONS OF COMPUTATIONAL FLUID MECHANICS | ENG APPL COMP FLUID | 1994-2060 | 1997-003X | 16 | 1 | SCIE | ENGINEERING, MECHANICAL;ENGINEERING, MULTIDISCIPLINARY;MECHANICS | 2022 | 6.1 | 8.4 | 0.2 | 2025-06-25 | 2 | 2 | Micro can combustor; lobed flame structure; recirculating flow; baffle thickness; lobe intensity; thermophotovoltaic generator | HEAT-TRANSFER; COMBUSTION; SIMULATION; SCHEMES | baffle thickness; lobe intensity; lobed flame structure; Micro can combustor; recirculating flow; thermophotovoltaic generator | English | 2022 | 2022-12-31 | 10.1080/19942060.2022.2130990 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Control of hippocampal prothrombin kringle-2 (pKr-2) expression reduces neurotoxic symptoms in five familial Alzheimer's disease mice | Background and Purpose There is a scarcity of information regarding the role of prothrombin kringle-2 (pKr-2), which can be generated by active thrombin, in hippocampal neurodegeneration and Alzheimer's disease (AD). Experimental Approach To assess the role of pKr-2 in association with the neurotoxic symptoms of AD, we determined pKr-2 protein levels in post-mortem hippocampal tissues of patients with AD and the hippocampi of five familial AD (5XFAD) mice compared with those of age-matched controls and wild-type (WT) mice, respectively. In addition, we investigated whether the hippocampal neurodegeneration and object memory impairments shown in 5XFAD mice were mediated by changes to pKr-2 up-regulation. Key Results Our results demonstrated that pKr-2 was up-regulated in the hippocampi of patients with AD and 5XFAD mice, but was not associated with amyloid-beta aggregation in 5XFAD mice. The up-regulation of pKr-2 expression was inhibited by preservation of the blood-brain barrier (BBB) via addition of caffeine to their water supply or by treatment with rivaroxaban, an inhibitor of factor Xa that is associated with thrombin production. Moreover, the prevention of up-regulation of pKr-2 expression reduced neurotoxic symptoms, such as hippocampal neurodegeneration and object recognition decline due to neurotoxic inflammatory responses in 5XFAD mice. Conclusion and Implications We identified a novel pathological mechanism of AD mediated by abnormal accumulation of pKr-2, which functions as an important pathogenic factor in the adult brain via blood brain barrier (BBB) breakdown. Thus, pKr-2 represents a novel target for AD therapeutic strategies and those for related conditions. | Kim, Sehwan; Moon, Gyeong Joon; Kim, Hyung Jun; Kim, Do-Geun; Kim, Jaekwang; Nam, Youngpyo; Sharma, Chanchal; Leem, Eunju; Lee, Shinrye; Kim, Kyu-Sung; Ha, Chang Man; McLean, Catriona; Jin, Byung Kwan; Shin, Won-Ho; Kim, Dong Woon; Oh, Yong-Seok; Hong, Chang-Won; Kim, Sang Ryong | Kyungpook Natl Univ, Sch Life Sci, 80 Daehakro, Daegu 41566, South Korea; Kyungpook Natl Univ, BK21 FOUR KNU Creat BioRes Grp, Daegu, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu, South Korea; Asan Med Ctr, Ctr Cell Therapy, Seoul, South Korea; Korea Brain Res Inst, Dementia Res Grp, Daegu, South Korea; Korea Brain Res Inst, Brain Res Core Facil, Daegu, South Korea; Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Victorian Brain Bank Network, Melbourne, Vic, Australia; Kyung Hee Univ, Sch Med, Dept Biochem & Mol Biol, Seoul, South Korea; Korea Inst Toxicol, Dept Predict Toxicol, Daejeon, South Korea; Chungnam Natl Univ, Brain Res Inst, Dept Anat, Sch Med, Daejeon, South Korea; Daegu Gyeongbuk Inst Sci & Technol, Dept Brain & Cognit Sci, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Physiol, Daegu, South Korea | ; Moon, Gyeong/P-7878-2019 | 57193232250; 8323365700; 57191717907; 55797863700; 57201935123; 55143100300; 57193577728; 56019011900; 17342428400; 57222671877; 7202560711; 7103396821; 55665810800; 7202123702; 57204150578; 55506315700; 55567018400; 56486163800 | srk75@knu.ac.kr; | BRITISH JOURNAL OF PHARMACOLOGY | BRIT J PHARMACOL | 0007-1188 | 1476-5381 | 179 | 5 | SCIE | PHARMACOLOGY & PHARMACY | 2022 | 7.3 | 8.5 | 1.14 | 2025-06-25 | 10 | 10 | Alzheimer's disease; blood-brain barrier; hippocampus; microglia; prothrombin kringle-2 | BLOOD-BRAIN-BARRIER; NEURONS IN-VIVO; INFLAMMATION; THROMBIN; BREAKDOWN; PROTECTS; DEATH; GUIDE | Alzheimer's disease; blood–brain barrier; hippocampus; microglia; prothrombin kringle-2 | Alzheimer Disease; Amyloid beta-Peptides; Animals; Disease Models, Animal; Hippocampus; Humans; Kringles; Mice; Mice, Transgenic; Prothrombin; Thrombin; amyloid beta protein; caffeine; prothrombin; prothrombin kringle 2; rivaroxaban; thrombin; unclassified drug; amyloid beta protein; prothrombin; thrombin; 5xFAD mouse; adult; age; Alzheimer disease; animal cell; animal experiment; animal tissue; Article; blood brain barrier; brain tissue; controlled study; disease association; disease control; female; hippocampus; human; human tissue; male; memory disorder; molecular pathology; mouse; nerve degeneration; neurotoxicity; nonhuman; protein aggregation; protein expression; protein function; upregulation; water supply; wild type mouse; animal; disease model; hippocampus; kringle domain; metabolism; transgenic mouse | English | 2022 | 2022-03 | 10.1111/bph.15681 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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