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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Extraction and characterization of exopolysaccharides from Lactiplantibacillus plantarum strain PRK7 and PRK 11, and evaluation of their antioxidant, emulsion, and antibiofilm activities | Exopolysaccharides (EPS) are produced by probiotic bacteria Lactiplantibacillus plantarum PRK7 and L. plantarum PRK11. The structure of EPS-7 and EPS-11 was characterized by Fourier-transform infrared (FTIR) spectroscopy, nuclear magnetic resonance (NMR), scanning electron microscopy (SEM), gas chromatography-mass spectros-copy (GCMS), and thermogravimetric analysis (TGA). Further, in in vitro studies antioxidant, emulsion, and antibiofilm activity were investigated. The FTIR spectrum confirmed the presence of polysaccharides in EPS-7 and EPS-11, with absorbance at 1654.93 and 1655.33 cm-1, respectively. H1 NMR further confirmed the pres-ence of glucose, galactose, xylose, and mannose. Sugar derivatives in EPS-7 and EPS-11 were further confirmed with GCMS. The SEM analysis revealed that EPS-7 had a weblike structure and EPS-11 had a smooth porous layer. The result of the TGA revealed that EPS-7 and EPS-11 had greater thermal stability at 319.1 and 300.1 degrees C, respectively. Furthermore, EPS-7 and EPS-11 showed a good percentage of free radical scavenging in DPPH (89.77 % and 93.1 %), ABTS (57.65 % and 58.63 %), hydroxyl radical scavenging (44.46 % and 40.308 %), and reducing power assay. The emulsion activity was confirmed with edible oils such as coconut oil, sesame oil, almond oil, castor oil, and neem oil. The highest emulsion activity for EPS-7 and EPS-11 was found with coconut and castor oil. In addition, the antibiofilm activity against pathogens revealed that EPS can prevent biofilm formation. Thus, it was found that EPS-7 and EPS-11 possess good structural characteristics and their biological activity makes them ideal for applications in the food and pharmaceutical industry. | Kowsalya, Mariyappan; Velmurugan, Thangavel; Mythili, R.; Kim, Woong; Sudha, Kattakgounder Govindaraj; Ali, Saheb; Kalpana, Balakrishnan; Ramalingam, Srinivasan; Rajeshkumar, Mohan Prasanna | KS Rangasamy Coll Arts & Sci Autonomous, Dept Biotechnol, Tiruchengode 637215, Tamil Nadu, India; Saveetha Inst Med & Tech Sci SIMATS, Saveetha Dent Coll, Ctr Transdisciplinary Res, Dept Pharmacol, Chennai 600077, Tamil Nadu, India; Kyungpook Natl Univ, Dept Environm Engn, Daegu, South Korea; Saveetha Inst Med & Tech Sci SIMATS, Saveetha Dent Coll & Hosp, Dept Periodont, Chennai 600077, Tamil Nadu, India; KSR Coll Technol, Dept Nanotechnol, Tiruchengode 637215, Tamil Nadu, India; Yeungnam Univ, Dept Hort & Life Sci, Gyongsan 38541, Gyeongsangbuk D, South Korea | Rajeshkumar, Prasanna/ABG-6004-2020; B, Kalpana/AAF-7720-2021; RajeshKumar, Prasanna/JWO-6606-2024; Mariyappan, Kowsalya/LFT-4462-2024; Ramalingam, Srinivasan/AAN-4585-2020 | 57194137828; 57353322600; 56765761500; 55581636400; 57214440280; 57216128831; 57220166054; 57202134239; 55647737000 | sribt27@ynu.ac.kr;prasanna@ksrcas.edu; | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | INT J BIOL MACROMOL | 0141-8130 | 1879-0003 | 242 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, APPLIED;POLYMER SCIENCE | 2023 | 7.7 | 5.8 | 1.82 | 2025-06-25 | 14 | 15 | Exopolysaccharide; Antioxidant activity; Emulsion; Antibiofilm activity; Lactiplantibacillus plantarum | STRUCTURAL-CHARACTERIZATION; LACTOBACILLUS; PURIFICATION; BIOACTIVITY; BACTERIA | Antibiofilm activity; Antioxidant activity; Emulsion; Exopolysaccharide; Lactiplantibacillus plantarum | Antioxidants; Biofilms; Emulsions; Polysaccharides, Bacterial; Spectroscopy, Fourier Transform Infrared; Antioxidants; Bioactivity; Emulsification; Fourier transform infrared spectroscopy; Free radicals; Gas chromatography; Mass spectrometry; Nuclear magnetic resonance; Nuclear magnetic resonance spectroscopy; Polysaccharides; Probiotics; Scanning electron microscopy; Spectrum analysis; 1,1 diphenyl 2 picrylhydrazyl; almond oil; carbohydrate; castor oil; coconut oil; exopolysaccharide; galactose; glucose; gum arabic; lactose; mannose; neem oil; probiotic agent; sesame seed oil; sucrose; xylose; antioxidant; bacterial polysaccharide; Antibiofilm activity; Antibiofilms; Antioxidant activities; Castor oil; Coconut oil; Exopolysaccharides; Gas chromatography-mass spectroscopies; L. plantarum; Lactiplantibacillus plantarum; Probiotic bacteria; ABTS radical scavenging assay; antibiofilm activity; antioxidant activity; Article; bacterial strain; controlled study; DPPH radical scavenging assay; drug analysis; emulsion; extraction; Fourier transform infrared spectroscopy; Gram positive bacterium; Lactiplantibacillus plantarum; nonhuman; prk11 strain; prk7 strain; biofilm; chemistry; emulsion; Thermogravimetric analysis | English | 2023 | 2023-07-01 | 10.1016/j.ijbiomac.2023.124842 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Fabrication of transparent cellulose nanofibril composite film with smooth surface and ultraviolet blocking ability using hydrophilic lignin | Ecofriendly multifunctional films with only biomass-based components have gathered significant interest from researchers as next-generation materials. Following this trend, a TEMPO-oxidized cellulose nanofibril (TOCNF) film containing hydrophilic lignin (CL) was fabricated. To produce the lignin, peracetic acid oxidation was carried out, leading to the introduction of carboxyl groups into the lignin structure. By adding hydrophilic lignin, various characteristics (e.g., surface smoothness, UV protection, antimicrobial activity, and barrier properties) of the TOCNF film were enhanced. In particular, the shrinkage of CNF was successfully prevented by the addition of CL, which is attributed to the lower surface roughness (Ra) from 18.93 nm to 4.99 nm. As a result, the smooth surface of the TOCNF/CL film was shown compared to neat TOCNF film and TOCNF/Kraft lignin composite film. In addition, the TOCNF/CL film showed a superior UV blocking ability of 99.9 % with high transparency of 78.4 %, which is higher than that of CNF-lignin composite films in other research. Also, water vapor transmission rate was reduced after adding CL to TOCNF film. Consequently, the developed TOCNF/CL film can be potentially utilized in various applications, such as food packaging. | Kim, Jong-Chan; Kim, Jonghwa; Cho, Young-Min; Cho, Seong-Min; Hwang, Sung-Wook; Kwak, Hyo Won; Yeo, Hwanmyeong; Choi, In-Gyu | Seoul Natl Univ, Dept Agr Forestry & Bioresources, 1 Gwanak ro, Seoul 08826, South Korea; Seoul Natl Univ, Res Inst Agr & Life Sci, 1 Gwanak ro, Seoul 08826, South Korea; North Carolina State Univ, Coll Nat Resources, Dept Forest Biomat, Raleigh, NC USA; Kyungpook Natl Univ, Human Resources Dev Ctr Big Data based Glocal Fore, Daegu 41566, South Korea | ; Kwak, Hyo/AAG-9875-2019; Choi, In-Gyu/AAS-1362-2020; Cho, Seong-Min/AAI-3007-2020 | 56650620000; 57203324906; 57217245658; 57094356900; 57139273300; 57220806677; 23112031200; 7401471763 | cingyu@snu.ac.kr; | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | INT J BIOL MACROMOL | 0141-8130 | 1879-0003 | 245 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, APPLIED;POLYMER SCIENCE | 2023 | 7.7 | 5.8 | 1.95 | 2025-06-25 | 15 | 16 | Ecofriendly multifunctional cellulose nanofibril; films; Hydrophilic lignin; Surface smoothness; UV blocking ability; Packaging | ACID | Ecofriendly multifunctional cellulose nanofibril films; Hydrophilic lignin; Packaging; Surface smoothness; UV blocking ability | Blocking; Cellulose; Construction; Film; Surfaces; Transparence; Water; Wettability; Cellulose; Cellulose, Oxidized; Lignin; Nanofibers; Steam; Cellulose films; Environmental protection; Fabrication; Hydrophilicity; Lignin; Nanocomposite films; Nanofibers; Surface roughness; carboxyl group; cellulose nanofiber; lignin; peracetic acid; cellulose; lignin; nanofiber; oxidized cellulose; Cellulose nanofibrils; Eco-friendly; Ecofriendly multifunctional cellulose nanofibril film; Hydrophilic lignin; Hydrophilics; Oxidized cellulose; Smooth surface; Surface smoothness; UV blocking; UV blocking ability; antimicrobial activity; Article; chemical structure; controlled study; food packaging; hydrophilicity; oxidation; permeability barrier; physical parameters; surface property; ultraviolet radiation; water vapor; chemistry; Cellulose | English | 2023 | 2023-08-01 | 10.1016/j.ijbiomac.2023.125545 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Glyphosate potentiates insulin resistance in skeletal muscle through the modulation of IRS-1/PI3K/Akt mediated mechanisms: An in vivo and in silico analysis | Herbicides have been linked to a higher risk of developing diabetes. Certain herbicides also operate as environmental toxins. Glyphosate is a popular and extremely effective herbicide for weed control in grain crops that inhibits the shikimate pathway. It has been shown to negatively influence endocrine function. Few studies have demonstrated that glyphosate exposure results in hyperglycemic and insulin resistance; but the molecular mechanism underlying the diabetogenic potential of glyphosate on skeletal muscle, a primary organ that includes insulin-mediated glucose disposal, is unknown. In this study, we aimed to evaluate the impact of glyphosate on the detrimental changes in the insulin metabolic signaling in the gastrocnemius muscle. In vivo results showed that glyphosate exposure caused hyperglycemia, dyslipidemia, increased glycosylated hemoglobin (HbA1c), liver function, kidney function profile, and oxidative stress markers in a dose-dependent fashion. Conversely, hemoglobin and antioxidant enzymes were significantly reduced in glyphosate-induced animals indicating its toxicity is linked to induce insulin resistance. The histopathology of the gastrocnemius muscle and RT-PCR analysis of insulin signaling molecules revealed glyphosate-induced alteration in the expression of IR, IRS-1, PI3K, Akt, 13-arrestin-2, and GLUT4 mRNA. Lastly, molecular docking and dynamics simulations confirmed that glyphosate showed a high binding affinity with target molecules such as Akt, IRS-1, c-Src, 13-arrestin-2, PI3K, and GLUT4. The current work provides experimental proof that glyphosate exposure has a deleterious effect on the IRS-1/PI3K/Akt signaling pathways, which in turn causes the skeletal muscle to become insulin resistant and eventually develop type 2 diabetes mellitus. | Jayaraman, Selvaraj; Krishnamoorthy, Kalaiselvi; Prasad, Monisha; Veeraraghavan, Vishnu Priya; Krishnamoorthy, Rajapandiyan; Alshuniaber, Mohammad A.; Gatasheh, Mansour K.; Elrobh, Mohamed; Gunassekaran | Saveetha Univ, Saveetha Dent Coll & Hosp, Saveetha Inst Med & Tech Sci, Ctr Mol Med & Diagnost COMManD,Dept Biochem, Chennai 600077, India; King Saud Univ, Coll Food & Agr Sci, Dept Food Sci & Nutr, Riyadh 11451, Saudi Arabia; King Saud Univ, Coll Sci, Dept Biochem, POB 2455, Riyadh 11451, Saudi Arabia; Kyungpook Natl Univ, Sch Med, Daegu, South Korea | Gatasheh, Mansour/AAP-9414-2021; Krishnamoorthy, Rajapandiyan/ABD-2564-2020; Jayaraman, Selvaraj/AFD-7539-2022; Veeraraghavan, Vishnu Priya/GVT-0445-2022; Prasad, Monisha/GZG-6621-2022; Alshuniaber, Mohammad/KRP-7207-2024; krishnamoorthy, Kalaiselvi/JMC-2813-2023 | 35171329100; 57481970000; 57372161200; 35730545100; 7102527961; 57209912020; 15742571400; 35487346400; 58255221300 | selvarajj.sdc@saveetha.com;kalaiselvik.sdc@saveetha.com;monishap.sdc@saveetha.com;vishnupriya@saveetha.com;moorthy@ksu.edu.sa;malshuniaber@ksu.edu.sa;mgatasheh@ksu.edu.sa;melrobh@ksu.edu.sa;ssekaran.guna@gmail.com; | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | INT J BIOL MACROMOL | 0141-8130 | 1879-0003 | 242 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, APPLIED;POLYMER SCIENCE | 2023 | 7.7 | 5.8 | 3.28 | 2025-06-25 | 19 | 27 | Glyphosate; Endocrine disruptor; Insulin resistance; Skeletal muscle; Type-2 diabetes | SIGNAL-TRANSDUCTION; MICROBIAL ACTIVITY; GLUCOSE-OXIDATION; BISPHENOL-A; GLUTATHIONE; PROTEIN; LIVER; PATHOGENESIS; EXPRESSION; TOXICITY | Endocrine disruptor; Glyphosate; Insulin resistance; Skeletal muscle; Type-2 diabetes | Animals; beta-Arrestins; Diabetes Mellitus, Type 2; Insulin; Insulin Resistance; Molecular Docking Simulation; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Binding energy; Hemoglobin; Insulin; Molecules; Muscle; Weed control; beta arrestin 2; glucose; glucose transporter 4; glyphosate; hemoglobin A1c; insulin; insulin receptor; insulin receptor substrate 1; messenger RNA; phosphatidylinositol 3 kinase; protein kinase B; protein tyrosine kinase; beta arrestin; glyphosate; insulin; phosphatidylinositol 3 kinase; protein kinase B; shikimic acid; Endocrine-disruptors; Gastrocnemius muscle; Glyphosates; In-silico; In-vivo; Insulin resistance; PI3K/Akt; Skeletal muscle; Type-2 diabetes; β-Arrestins; animal experiment; animal model; animal tissue; Article; binding affinity; computer model; controlled study; dyslipidemia; fasting blood glucose level; gastrocnemius muscle; histopathology; hyperglycemia; in vivo study; insulin blood level; insulin metabolism; insulin resistance; insulin signaling; kidney function; liver function; male; molecular docking; molecular dynamics; nonhuman; oxidative stress; protein expression; rat; animal; insulin resistance; metabolism; non insulin dependent diabetes mellitus; skeletal muscle; Herbicides | English | 2023 | 2023-07-01 | 10.1016/j.ijbiomac.2023.124917 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Meeting Abstract | Induction of choroidal neovascularization by laser treatment in mice affects home cage behavior | Park, Hyun Woo; Park, Kyungho; Lee, Hee Young; Kim, Yeongyeong; Lim, Byeongyeon; Lee, Ajin; Lee, Ah Hyun; Kwon, Jae Young; Park, Larry | Naason Sci Inc, Osong Eup, South Korea; Kyungpook Natl Univ, Daegu, South Korea | Lee, Hee-Young/ABF-9167-2021 | INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | INVEST OPHTH VIS SCI | 0146-0404 | 1552-5783 | 64 | 8 | SCIE | OPHTHALMOLOGY | 2023 | 5 | 5.8 | 0 | English | 2023 | 2023-06 | 바로가기 | 바로가기 | |||||||||||||||
| ○ | ○ | Article | Molecular mechanism underlying high-affinity terephthalate binding and conformational change of TBP from Ideonella sakaiensis | Ideonella sakaiensis is the bacterium that can survive by degrading polyethylene terephthalate (PET) plastic, and terephthalic acid (TPA) binding protein (IsTBP) is an essential periplasmic protein for uptake of TPA into the cytosol for complete degradation of PET. Here, we demonstrated that IsTBP has remarkably high specificity for TPA among 33 monophenolic compounds and two 1,6-dicarboxylic acids tested. Structural comparisons with 6-carboxylic acid binding protein (RpAdpC) and TBP from Comamonas sp. E6 (CsTphC) revealed the key structural features that contribute to high TPA specificity and affinity of IsTBP. We also elucidated the molecular mech-anism underlying the conformational change upon TPA binding. In addition, we developed the IsTBP variant with enhanced TPA sensitivity, which can be expanded for the use of TBP as a biosensor for PET degradation. | Lee, Seul Hoo; Seo, Hogyun; Hong, Hwaseok; Kim, Mijeong; Kim, Kyung-Jin | Kyungpook Natl Univ, KNU Inst Microorganisms, Sch Life Sci, KNU Creat Biores Grp BK21 4, Daegu 41566, South Korea; Zyen Co, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Life Sci, KNU Creat Biores Grp, Daegu 41566, South Korea | Kim, Kyung-Jin/MVY-3405-2025 | 57205261937; 57189697998; 57208592877; 57360727100; 55510867400 | kkim@knu.ac.kr; | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | INT J BIOL MACROMOL | 0141-8130 | 1879-0003 | 243 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, APPLIED;POLYMER SCIENCE | 2023 | 7.7 | 5.8 | 0.24 | 2025-06-25 | 2 | 2 | Ideonella sakaiensis; TPA uptake; TPA binding protein; Conformational change; Protein engineering | CRYSTAL-STRUCTURE; LIGAND-BINDING; PROTEIN; DEGRADATION; CLASSIFICATION; FAMILY; PETASE; WASTE | Conformational change; Ideonella sakaiensis; Protein engineering; TPA binding protein; TPA uptake | Burkholderiales; Comamonas; Hydrolases; Ideonella sakaiensis; Phthalic Acids; Degradation; Plastic bottles; Proteins; 1,6 dicarboxylic acid; binding protein; dicarboxylic acid; phenol derivative; polyethylene terephthalate; terephthalic acid; terephthalic acid binding protein; unclassified drug; hydrolase; phthalic acid derivative; terephthalic acid; Acid-binding proteins; Conformational change; High affinity; Ideonellum sakaiensis; Molecular mechanism; Protein engineering; Terephthalic acid binding protein; Terephthalic acid uptake; Terephthalic acids; Article; bacterium; binding affinity; Comamonas; conformational transition; controlled study; crystallization; degradation; differential scanning calorimetry; Ideonella sakaiensis; isothermal titration calorimetry; nonhuman; protein conformation; protein expression; protein purification; site directed mutagenesis; size exclusion chromatography; Burkholderiales; chemistry; Comamonas; Polyethylene terephthalates | English | 2023 | 2023-07-15 | 10.1016/j.ijbiomac.2023.125252 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Nanostructured chitosan-polyphenolic patch for remote NIR-photothermal controlled dermal drug delivery | We describe the synthesis of a nanostructured dermal patch composed of chitosan-tannic acid (CT) that can carry near-infrared (NIR) active Indocyanine green (ICG) dye for performing photothermal heat conversion activity. The NIR-responsive CT-I dermal patch can deliver topical antibiotic drugs (Neomycin). The CT-I and drug-loaded CT-I/N patches have been demonstrated by FTIR, SEM/EDX, TGA, and DSC analysis. The in vitro drug release from the CT-I/N patch are favorable in the dermal environment (pH = 5.5) and significantly increases 25 % more at higher temperatures of 40 to 45 degrees C. The CT-I/N showed increasing photothermal heat in response to NIR (808 nm) light. The in vivo thermograph demonstrated that the CT-I/N patch can generate >45 degrees C within 5 min NIR irradiation. As a result, sustained wound healing was shown in H&E (hematoxylin and eosin) staining dermal tissue. Such NIR-active nanostructure film/patch is promising for the future of any sustained on-demand drug delivery system. | Rahman, Muntasir; Chowdhury, Fariha; Uddin, Kamal; Ahmed, Khondoker Shahin; Hossain, Hemayet; Jain, Preeti; Reza, Hasan Mahmud; Lee, Kyueui; Sharker, Shazid Md | North South Univ, Dept Pharmaceut Sci, Plot 15,Block B, Dhaka 1229, Bangladesh; Bangladesh Council Sci & Ind Res BCSIR, BCSIR Labs, Dhaka 1205, Bangladesh; Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea | Lee, Kyueui/ACR-8902-2022; shahin, Khondoker/O-6195-2018; Reza, Hasan Mahmud/AFL-0151-2022; Sharker, Shazid/S-6210-2019; Chowdhury, Fariha/KBA-5187-2024; hossain, hemayet/O-5996-2018; Lee, Kyueui/P-8152-2018; jain, preeti/IUO-8411-2023 | 57706135900; 57814559100; 58580554600; 57204237708; 56278087600; 26659998800; 6603830556; 56404800600; 57210229996 | shazid.sharker@northsouth.edu; | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | INT J BIOL MACROMOL | 0141-8130 | 1879-0003 | 241 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, APPLIED;POLYMER SCIENCE | 2023 | 7.7 | 5.8 | 1.7 | 2025-06-25 | 13 | 14 | Photothermal heat; Dermal patch; Local drug delivery | TANNIC-ACID; IN-VITRO; RELEASE; HYDROGEL; THERAPY; LIGHT; NANOPARTICLES; PREVENTION; SYSTEM | Dermal patch; Local drug delivery; Photothermal heat | Chitosan; Doxorubicin; Drug Delivery Systems; Drug Liberation; Hot Temperature; Nanostructures; chitosan; indocyanine green; neomycin; polyphenol derivative; tannin; doxorubicin; nanomaterial; antimicrobial activity; Article; bacterium culture; dermal drug delivery; differential scanning calorimetry; drug delivery system; drug release; energy dispersive X ray spectroscopy; Fourier transform infrared spectroscopy; histology; human; human tissue; in vivo study; near infrared spectroscopy; photothermal therapy; scanning electron microscopy; skin culture; Staphylococcus aureus; synthesis; thermogravimetry; wound healing; chemistry; drug delivery system; high temperature | English | 2023 | 2023-06-30 | 10.1016/j.ijbiomac.2023.124701 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Novel edible films fabricated with HG-type pectin extracted from different types of hybrid citrus peels: Effects of pectin composition on film properties | This study investigated the valorization of novel HG-type hybrid citrus pectins derived from three cultivars: Setoka (ST), Kanpei (KP), and Shiranui (SH), and their application as packaging materials. The physicochemical properties of these pectins and their corresponding films were evaluated and compared to commercial citrus pectin. Significant variations were observed in pectin yield (18.15-24.12 %) and other physicochemical characteristics, such as degree of esterification (DE), degree of methoxylation (DM), and monosaccharide composition, among the different cultivars. All hybrid citrus pectins were classified as high-methoxy pectin types (66.67-72.89 %) with typical structural configurations like commercial citrus pectin. However, hybrid citrus pectin films exhibited superior physical properties, including higher mechanical strength, flexibility, and lower water solubility than commercial citrus pectin film, while maintaining similar transparency and moisture content. Additionally, the films displayed smooth and uniform surface morphology, confirming their excellent filmforming properties. Correlation analysis revealed that DE positively influenced mechanical properties (r = 1.0). Furthermore, the monosaccharide composition of pectins showed strong relationships (r = 0.8-1.0) with the film's mechanical and barrier properties. These findings highlight the potential of hybrid citrus pectin as potential packaging material, and the knowledge of the structure-function relationship obtained in this study could be useful for the tailored modification of citrus pectin-based packages. | Said, Nurul Saadah; Olawuyi, Ibukunoluwa Fola; Cho, Ha-Seong; Lee, Won-Young | Kyungpook Natl Univ, Sch Food Sci & Technol, Daegu 702701, South Korea; Kyungpook Natl Univ, Res Inst Tailored Food Technol, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea | ; Said, Nurul Saadah/LFV-3208-2024; Olawuyi, Ibukunoluwa/H-1232-2018; Lee, Wonyoung/AAL-2780-2021 | 57211398275; 57204471854; 58188941600; 57195940408 | wonyoung@knu.ac.kr; | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | INT J BIOL MACROMOL | 0141-8130 | 1879-0003 | 253 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, APPLIED;POLYMER SCIENCE | 2023 | 7.7 | 5.8 | 2.19 | 2025-06-25 | 17 | 18 | Pectin; Hybrid citrus peel; Biodegradable film; Film properties | POTENTIAL USE; BY-PRODUCTS; LIME PEEL; ANTIOXIDANT; BARRIER; OPTIMIZATION; PLASTICIZER; MICROWAVE; PRESSURE; BEHAVIOR | Biodegradable film; Film properties; Hybrid citrus peel; Pectin | Citrus; Edible Films; Monosaccharides; Pectins; Solubility; Glucose; Hybrid materials; Morphology; Physicochemical properties; Surface morphology; homogalacturonan; monosaccharide; pectin; polysaccharide; unclassified drug; pectin; Biodegradable film; Citrus pectin; Citrus peel; Edible films; Films properties; Hybrid citrus peel; Monosaccharide composition; Pectin; Pectin films; Valorisation; Article; chemical composition; chemical modification; chemical reaction; citrus pectin film; citrus peel; controlled study; correlation analysis; cultivar; edible packaging; esterification; extraction; flexibility; fruit peel; Kanpei; mechanical strength; mechanics; methoxylation; moisture; nonhuman; physical chemistry; physical parameters; Setoka; Shiranui; structure activity relation; surface property; valorization; water solubility; chemistry; Citrus; solubility; Packaging materials | English | 2023 | 2023-12-31 | 10.1016/j.ijbiomac.2023.127238 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Article | Optimization of entropy generation and thermal mechanism of MHD hybrid nanoliquid flow in a sinusoidally heated porous cylindrical chamber | The present computational investigation explores the fluid and thermal characteristics along with entropy generation due to buoyancy-driven magnetohydrodynamic (MHD) convective flow of aqueous hybrid nanoliquid filled in a nonuniformly heated porous cylindrical chamber. The fluid motion in the enclosure is modeled by Brinkman - extended Darcy model. The modeled equations are resolved by finite difference approach. The computations are conducted for Rayleigh number (103-105), Hartmann number (0-50), Darcy number (10-5-10-1), different nanoparticle shapes and nanoparticle volume fraction (Ag/MgO: 0-0.05) to understand the characteristic of flow, thermal and irreversibility distribution. With vast numerical simulations, the outcomes reveal that though the buoyancy force is greater, the fluidity cannot be enhanced unless the permeability and magnetic field strength are optimally maintained. As Ra, Ha and Da is varied respectively from 103 to 105, 50 to 0 and 10-5 to 10-1, the fluidity has been enhanced by 99.39%, 83.26% and 99.79%. Among all considered parametric combinations, it has been noticed that the choice of Ha = 0, Ra = 105, Da = 10-1 with proper ratio of nanoparticles enhance the system efficiency. However, minimal entropy generation can be achieved with greater Hartmann and lower Darcy numbers. Furthermore, it has been found that blade shaped nanoparticles lead to increase the performance of thermal system. | Swamy, H. A. Kumara; Sankar, M.; Reddy, N. Keerthi; Do, Younghae | Kyungpook Natl Univ, Nonlinear Dynam & Math Applicat Ctr, Dept Math, Daegu 41566, South Korea; Univ Technol & Appl Sci, Dept Informat Technol, Ibri 516, Oman; Ulsan Natl Inst Sci & Technol, Dept Mech Engn, Ulsan 44919, South Korea | Reddy N., Keerthi/AAT-5305-2021; Do, Younghae/G-3522-2011; Mani, Sankar/AAT-5256-2021; Swamy, H.A. Kumara/AAT-5304-2021; , KEERTHI REDDY N/AAT-5305-2021 | drhaks@knu.ac.kr;manisankariyer@gmail.com;keerthireddyn2711@gmail.com;yhdo@knu.ac.kr; | CASE STUDIES IN THERMAL ENGINEERING | CASE STUD THERM ENG | 2214-157X | 51 | SCIE | THERMODYNAMICS | 2023 | 6.4 | 5.8 | 12 | Entropy generation; Hybrid nanoliquid; Lorentz force; Nanoparticle shape factor; Porous medium | NATURAL-CONVECTION; CAVITY; NANOFLUID; ENCLOSURE; SIMULATION | English | 2023 | 2023-11 | 10.1016/j.csite.2023.103615 | 바로가기 | 바로가기 | 바로가기 | |||||||||||
| ○ | ○ | Article | Overexpression of acdS in petunia improved tolerance to copper stress by reducing ethylene production and metal accumulation | We overexpressed the 1-aminocyclopropane-1-carboxylic acid (ACC) deaminase gene (acdS), which encodes the enzyme responsible for the degradation of an ethylene precursor (ACC), in Petunia hybrida cv. Mirage Rose. We investigated whether acdS overexpression rendered the petunia more tolerant to copper (Cu) stress. The transgenic plants exhibited greater tolerance to Cu stress than wild type (WT) plants, as evidenced by better plant growth and physiological performances. Additionally, the transgenic plants displayed significantly suppressed ethylene production and related genes, elevated expression of antioxidant and proline activity-related genes, reduced accumulation of reactive oxygen species and Cu, and increased expression of genes regulating heavy metal when compared to the WT plants. These findings elucidate the mechanism by which acdS imparts Cu stress tolerance, suggesting that overexpressing acdS in plants can facilitate their resilience to Cu stress. | Campol, Jova Riza; Naing, Aung Htay; Chung, Mi Young; Kim, Won-Chan; Kim, Chang Kil | Kyungpook Natl Univ, Dept Hort Sci, Daegu, South Korea; Sunchon Natl Univ, Dept Agr Educ, Sunchon, South Korea; Kyungpook Natl Univ, Sch Appl Biosci, Daegu, South Korea | Naing, Aung Htay/AAF-4277-2019; KIM, WON/AAJ-4506-2020 | 57486378900; 37112768100; 24821361600; 55492085000; 7409880701 | ckkim@knu.ac.kr; | PLANT STRESS | PLANT STRESS | 2667-064X | 10 | ESCI | PLANT SCIENCES | 2023 | 6.8 | 5.8 | 0 | 2025-06-25 | 0 | 0 | ACC deaminase; Cu stress; Ethylene production; Gene expression; Plant growth; Reactive oxygen species (ROS) | GROWTH-PROMOTING BACTERIUM; ARABIDOPSIS PHYTOCHELATIN SYNTHASE; INDUCED OXIDATIVE STRESS; PLANT-GROWTH; ACC DEAMINASE; CONTAMINATED SOIL; TRANSGENIC CANOLA; ROOT ELONGATION; EXPRESSION; CADMIUM | ACC deaminase; Cu stress; Ethylene production; Gene expression; Plant growth; Reactive oxygen species (ROS) | English | 2023 | 2023-12 | 10.1016/j.stress.2023.100233 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Porous chitosan-infused graphitic carbon nitride nanosheets for potential microbicidal and photo-catalytic efficacies | Supply of safe drinking water is a high-risk challenge faced internationally. Hybrid technologies involving nanomaterials can offer possible solutions to this research involving natural biopolymers. Porous chitosan with a high specific surface area has promising properties but its use as a membrane component in water purification is still rarely reported. Graphitic carbon nitride (g-C3N4) is a carbon nitride allotrope with a graphene-like layered structure that gifts unfamiliar physicochemical properties due to the presence of s-triazine fragments. It is a metal-free semiconductor with a band gap of-2.7 eV to-3.7 eV; which shows better visible light-activated photocatalyst properties. This work aims at synthesizing graphitic carbon nitride-biopolymer composite and exploring its properties in the field of wastewater treatment. The samples were synthesized via a soft chemical process with urea, as the source material. The flake-like morphology is displayed in the microstructural SEM image. The composition of the material was analyzed using EDS. Thermogram shows that the material is stable up to 500 degrees C and also confirms the formation of graphitic carbon nitride. In XRD spectra the intensity reduction shows the chitosan inclusion at the nitride site. The band gap of the prepared material was identified to be 2.3, 2.4 eV. The structural properties were analyzed using Fourier Transform Infrared Spectrometer and Raman spectroscopy. FTIR spectra and Raman spectra indicate the stretching vibration modes of C--N and C-N het-erocycles and chitosan inclusion in the carbon nitride network. The photocatalytic activity was done in sunlight and a UV lamp with different dyes for doped and undoped g-C3N4. The doped (Porous/Non-porous chitosan) g-C3N4 showed faster dye degradation in sunlight compared to UV light. A biomolecular interaction study was done using Bovine serum albumin. It shows the material interaction with the BSA protein. The anti-microbial activity was performed on the Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli by disk diffusion method, the chitosan doped g-C3N4 showed good inhibitions against bacterial growth. The current work reveals the impact of nanoscale chitosan nanostructures doped on the optical, microstructural, catalytic, and antimicrobial properties of g-C3N4 nanosheets. This work provides new research options for nanocomposite-based photocatalytic nanomaterial g-C3N4 so that the quality of contaminated water could be improved. | Praseetha, P. K.; Godwin, M. Anto; AlSalhi, Mohamad S.; Devanesan, Sandhanasamy; Vijayakumar, S.; Sangeetha, R.; Prathipkumar, S.; Kim, Woong | Noorul Islam Ctr Higher Educ, Dept Nanotechnol, Kumaracoil, Tamil Nadu, India; King Saud Univ, Coll Sci, Dept Phys & Astron, POB 2455, Riyadh 11451, Saudi Arabia; AVVM Sri Pushpam Coll, PG & Res Dept Bot, Poondi 613503, India; AVVM Sri Pushpam Coll, PG & Res Dept Math, Poondi, India; SRM Inst Sci & Technol, Nanotechnol Res Ctr, Chennai, India; Kyungpook Natl Univ, Dept Environm Engn, Daegu, South Korea | Devanesan, Dr. Sandhanasamy/ABH-3378-2021; P.K, Praseetha/AAS-7032-2020; Devanesan, Sandhanasamy/ABH-3378-2021 | 55745039800; 58160273500; 10440259800; 55279721800; 14061369800; 59612154900; 57210173215; 55581636400 | nanohod@niuniv.com;svijaya_kumar2579@rediffmail.com; | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | INT J BIOL MACROMOL | 0141-8130 | 1879-0003 | 238 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, APPLIED;POLYMER SCIENCE | 2023 | 7.7 | 5.8 | 1.95 | 2025-06-25 | 13 | 16 | Porous chitosan; Photocatalyst; Antibacterial; Photodegradation; BSA | NANOPARTICLES; DYE | Antibacterial; BSA; g-C<sub>3</sub>N<sub>4</sub>; Photocatalyst; Photodegradation; Porous chitosan | Anti-Infective Agents; Catalysis; Chitosan; Graphite; biopolymer; bovine serum albumin; carbon; chitosan; chitosan nanoparticle; dye; graphene; graphite; graphitic carbon nitride nanosheet; heterocyclic compound; nanosheet; nitrogen; unclassified drug; urea; antiinfective agent; chitosan; cyanogen; graphite; graphitic carbon nitride; antibacterial activity; antimicrobial activity; Article; chemical composition; chemical structure; controlled study; disk diffusion; energy dispersive X ray spectroscopy; Escherichia coli; Fourier transform infrared spectroscopy; molecular interaction; nonhuman; photocatalysis; photodegradation; porosity; Pseudomonas aeruginosa; Raman spectrometry; scanning electron microscopy; Staphylococcus aureus; sunlight; synthesis; thermogravimetry; thermostability; ultraviolet radiation; vibration; waste water management; water contamination; X ray diffraction; catalysis; chemistry | English | 2023 | 2023-05-31 | 10.1016/j.ijbiomac.2023.124120 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Production of various phenolic aldehyde compounds using the 4CL-FCHL biosynthesis platform | Vanillin (3-methoxy-4-hydroxybenzaldehyde) is one of the most important flavoring substances used in the cosmetic and food industries. Feruloyl-CoA hydratase/lyase (FCHL) is an enzyme that catalyzes the production of vanillin from feruloyl-CoA. In this study, we report kinetic parameters and biochemical properties of FCHL from Sphingomonas paucimobilis SYK-6 (SpFCHL). Also, the crystal structures of an apo-form of SpFCHL and two complexed forms with acetyl-CoA and vanillin/CoA was present. Comparing the apo structure to its complexed forms of SpFCHL, a gate loop with an "open and closed" role was observed at the entrance of the substrate -binding site. With vanillin and CoA complexed to SpFCHL, we captured a conformational change in the fer-uloyl moiety-binding pocket that repositions the catalytic SpFCHLE146 and other key residues. This binding pocket does not tightly fit the vanillin structure, suggesting substrate promiscuity of this enzyme. This obser-vation is in good agreement with assay results for phenylpropanoid-CoAs and indicates important physico-chemical properties of the substrate for the hydratase/lyase reaction mechanism. In addition, we showed that various phenolic aldehydes could be produced using the 4CL-FCHL biosynthesis platform. | Seok, Jihye; Seo, Hogyun; Hong, Jiyeon; Kim, Kyung-Jin | Kyungpook Natl Univ, Sch Life Sci, FOUR KNU Creat Biores Grp BK21, Daegu 41566, South Korea; Pohang Univ Sci & Technol, Pohang Accelerator Lab, Pohang 37673, South Korea; Kyungpook Natl Univ, KNU Inst Microorganisms, Daehak ro 80, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Life Sci, Struct & Mol Biol Lab, Room 619,Integrated Nat Sci Bldg,Daehak ro 80, Daegu, South Korea | Kim, Kyung-Jin/MVY-3405-2025 | 57216545714; 57189697998; 57205354591; 55510867400 | kkim@knu.ac.kr; | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | INT J BIOL MACROMOL | 0141-8130 | 1879-0003 | 226 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, APPLIED;POLYMER SCIENCE | 2023 | 7.7 | 5.8 | 0.24 | 2025-06-25 | 2 | 2 | Vanillin; Bio-production; Feruloyl-CoA hydratase; lyase (FCHL); 4-Coumarate; CoA ligase (4CL); Phenolic aldehydes | HYDRATASE-LYASE HCHL; FERULIC ACID; COA HYDRATASE; PSEUDOMONAS-FLUORESCENS; PROTOCATECHUIC ALDEHYDE; SUBSTRATE-SPECIFICITY; COENZYME-A; VANILLIN; BIOCONVERSION; BIOTRANSFORMATION | 4-Coumarate; Bio-production; CoA ligase (4CL); Feruloyl-CoA hydratase/lyase (FCHL); Phenolic aldehydes; Vanillin | Acyl Coenzyme A; Aldehydes; Lyases; 4 coumarate coenzyme A ligase; coenzyme A ligase; feruloyl coenzyme A hydratase lyase; lyase; phenol derivative; phenolic aldehyde; unclassified drug; vanillin; 3-hydroxybenzaldehyde; acyl coenzyme A; aldehyde; feruloyl-CoA; Article; binding site; biosynthesis; conformational transition; controlled study; crystal structure; enzyme mechanism; enzyme substrate complex; kinetic parameters; physical chemistry; Sphingomonas paucimobilis | English | 2023 | 2023-01-31 | 10.1016/j.ijbiomac.2022.12.075 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Randomised clinical trial: comparison of tegoprazan and lansoprazole as maintenance therapy for healed mild erosive oesophagitis | Background Tegoprazan is a novel potassium-competitive acid blocker used to treat acid-related disorders. Aim To compare tegoprazan 25 mg with lansoprazole 15 mg as maintenance therapy in healed erosive oesophagitis (EE) Methods In this phase 3, double-blind, multi-centre study, patients with endoscopically confirmed healed EE were randomised 1:1 to receive tegoprazan 25 mg or lansoprazole 15 mg once daily for up to 24 weeks. The primary efficacy endpoint was the endoscopic remission rate after 24 weeks. The secondary efficacy endpoint was the endoscopic remission rate after 12 weeks. Safety endpoints included adverse events, clinical laboratory results and serum gastrin and pepsinogen I/II levels. Results We randomised patients to tegoprazan 25 mg (n = 174) or lansoprazole 15 mg (n = 177). Most had mild EE (Los Angeles (LA) grade A: 57.3%, LA grade B: 37.3%). The endoscopic remission rate after 24 weeks was 90.6% with tegoprazan and 89.5% with lansoprazole. Tegoprazan was not inferior to lansoprazole for maintaining endoscopic remission at 24 weeks and 12 weeks. In subgroup analysis, tegoprazan 25 mg showed no significant difference in maintenance rate according to LA grade (p = 0.47). The maintenance effect of tegoprazan was consistent in CYP2C19 extensive metabolisers (p = 0.76). Increases in serum gastrin were not higher in tegoprazan-treated than lansoprazole-treated patients. Conclusions Tegoprazan 25 mg was non-inferior to lansoprazole 15 mg in maintenance of healing of mild EE. In this study, tegoprazan had a similar safety profile to lansoprazole. | Cho, Yu Kyung; Kim, Jae Hak; Kim, Hyun-Soo; Kim, Tae-Oh; Oh, Jung-Hwan; Choi, Suck Chei; Moon, Jeong Seop; Lee, Sang Kil; Jung, Sung Woo; Kim, Sung Soo; Jung, Hye-Kyung; Lee, Sang Pyo; Cheon, Gab-Jin; Park, Moo In; Jung, Hwoon-Yong; Ko, Kwang Hyun; Sung, In Kyung; Lee, Si Hyung; Lee, Ju Yup; Lee, Soo Teik; Rhee, Poong-Lyul; Kim, Nayoung; Hong, Su Jin; Kim, Hyun Jin; Kim, Gwang Ha; Lee, Kwang Jae; Kim, Sung Kook; Shin, Woon Geon; Lee, Oh Young | Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Catholic Photomed Res Inst, Seoul, South Korea; Dongguk Univ, Ilsan Hosp, Coll Med, Dept Internal Med, Goyang, South Korea; Yonsei Univ, Wonju Christian Hosp, Wonju Coll Med, Dept Internal Med, Wonju, South Korea; Inje Univ, Haeundae Paik Hosp, Dept Internal Med, Busan, South Korea; Catholic Univ Korea, Eunpyeong St Marys Hosp, Coll Med, Dept Internal Med, Seoul, South Korea; Wonkwang Univ Hosp, Dept Internal Med, Iksan, South Korea; Inje Univ, Seoul Paik Hosp, Dept Internal Med, Seoul, South Korea; Yonsei Univ, Severance Hosp, Coll Med, Dept Internal Med, Seoul, South Korea; Korea Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Catholic Univ Korea, Uijeongbu St Marys Hosp, Coll Med, Dept Internal Med, Uijongbu, South Korea; Ewha Womans Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Hallym Univ, Dongtan Sacred Heart Hosp, Dept Internal Med, Hwaseong, South Korea; Ulsan Univ, GangNeung Asan Hosp, Coll Med, Dept Internal Med, Kangnung, South Korea; Kosin Univ, Coll Med, Dept Internal Med, Busan, South Korea; Univ Ulsan, Asan Med Ctr, Dept Gastroenterol, Seoul, South Korea; CHA Univ, Digest Dis Ctr, CHA Bundang Med Ctr, Seongnam, South Korea; Konkuk Univ, Med Ctr, Dept Internal Med, Seoul, South Korea; Yeungnam Univ, Coll Med, Dept Internal Med, Daegu, South Korea; Keimyung Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Jeonbuk Natl Univ Hosp, Dept Internal Med, Jeonju, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Med, Seoul, South Korea; Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Seongnam, South Korea; Seoul Natl Univ, Coll Med, Seoul, South Korea; Soonchunhyang Univ, Coll Med, Dept Internal Med, Bucheon, South Korea; Gyeongsang Natl Univ, Changwon Hosp, Dept Internal Med, Chang Won, South Korea; Pusan Natl Univ, Coll Med, Dept Internal Med, Busan, South Korea; Pusan Natl Univ Hosp, Biomed Res Inst, Busan, South Korea; Ajou Univ, Ajou Univ Hosp, Sch Med, Dept Gastroenterol, Suwon, South Korea; Kyungpook Natl Univ Hosp, Dept Internal Med, Daegu, South Korea; Hallym Univ, Coll Med, Inst Liver & Digest Dis, Dept Internal Med, Chunchon, South Korea; Hanyang Univ, Coll Med, Dept Internal Med, Seoul, South Korea | Kim, Seok-Hwan/G-9981-2015; Rhee, Poong/C-9655-2011; Kwak, Sang Gyu/AAG-4341-2021; Lee, Yoojin/AAB-9799-2022; Lee, Jee-Yon/GER-4141-2022; Kim, Hyung/J-5451-2012; Kim, Nayoung/J-5387-2012; Lee, In/J-9324-2013; Kim, Gwang Ha/ABF-3932-2021; Lee, Si/ABH-1408-2020; Oh, Jung-Hwan/HZL-3050-2023 | 23491673100; 50161761100; 55739553100; 57189056554; 57225962939; 7408119608; 36942318200; 49963940700; 35174493300; 57951283700; 7403029723; 57192516374; 7003953934; 8666034000; 7403029804; 35327264300; 57226383709; 35771122400; 55891683700; 7601418502; 7006801843; 57201181440; 35285527200; 57201620344; 35214772400; 35345240300; 34770060400; 13606883400; 24477520300 | leeoy@hanyang.ac.kr; | ALIMENTARY PHARMACOLOGY & THERAPEUTICS | ALIMENT PHARM THER | 0269-2813 | 1365-2036 | 57 | 1 | SCIE | GASTROENTEROLOGY & HEPATOLOGY;PHARMACOLOGY & PHARMACY | 2023 | 6.6 | 5.8 | 5.46 | 2025-06-25 | 28 | 29 | PROTON PUMP INHIBITORS; REFLUX ESOPHAGITIS; VONOPRAZAN | Gastrins; Humans; Lansoprazole; alanine aminotransferase; creatine kinase; cytochrome P450 2C19; dexlansoprazole; esomeprazole; gamma glutamyltransferase; gastrin; lansoprazole; pantoprazole; pepsinogen I; pepsinogen II; rabeprazole; tegoprazan; gastrin; lansoprazole; abdominal pain; adult; adverse event; aged; alanine aminotransferase blood level; Article; chronic gastritis; controlled study; coughing; creatine kinase blood level; diarrhea; disease severity; dizziness; double blind procedure; drug efficacy; drug safety; drug tolerability; dyspepsia; dysuria; endoscopy; erosive gastritis; female; gamma glutamyl transferase blood level; gastrin blood level; headache; healing; human; hypergastrinemia; laboratory test; maintenance therapy; major clinical study; male; middle aged; multicenter study; patient selection; phase 3 clinical trial; protein blood level; randomization; randomized controlled trial; reflux esophagitis; relapse; remission; rhinopharyngitis; side effect; stomach polyp; treatment duration; treatment outcome; young adult; clinical trial | English | 2023 | 2023-01 | 10.1111/apt.17255 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Ruled real hypersurfaces in the complex hyperbolic quadric | In this article, we introduce a new family of real hypersurfaces in the complex hyperbolic quadric Q(n & lowast;)=SO2,no/SO2SOn , namely, the ruled real hypersurfaces foliated by complex hypersurfaces. Berndt described an example of such a real hypersurface in Q(n & lowast;) as a homogeneous real hypersurface generated by a (sic) -principal horocycle in a real form RHn . So, in this article, we compute a detailed expression of the shape operator for ruled real hypersurfaces in Q(n & lowast;) and investigate their characterizations in terms of the shape operator and the integrable distribution C={X is an element of TM divided by X perpendicular to xi} . Then, by using these observations, we give two kinds of classifications of real hypersurfaces in Q(n & lowast;) satisfying eta -parallelism under either eta -commutativity of the shape operator or integrability of the distribution C . Moreover, we prove that the unit normal vector field of a real hypersurface with eta -parallel shape operator in Q(n & lowast;) is (sic) -principal. On the other hand, it is known that all contact real hypersurfaces in Q(n & lowast;) have a (sic) -principal normal vector field. Motivated by these results, we give a characterization of contact real hypersurfaces in Q(n & lowast;) in terms of eta -parallel shape operator. | Lee, Hyunjin; Suh, Young Jin; Woo, Changhwa | Pukyong Natl Univ, Dept Appl Math, Busan 48547, South Korea; Chosun Univ, Dept Math Educ, Gwangju 61452, South Korea; Kyungpook Natl Univ, Dept Math, Daegu 41566, South Korea; Kyungpook Natl Univ, Res Inst Real & Complex Manifolds, Daegu 41566, South Korea | 55706812200; 57205268556; 56075678000 | lhjibis@hanmail.net;yjsuh@knu.ac.kr;legalgwch@pknu.ac.kr; | DEMONSTRATIO MATHEMATICA | DEMONSTR MATH | 0420-1213 | 2391-4661 | 56 | 1 | SCIE | MATHEMATICS | 2023 | 2 | 5.8 | 0.4 | 2025-06-25 | 1 | 1 | ruled real hypersurface; eta-parallel shape operator; eta-commuting shape operator; singular vector fields; complex hyperbolic quadric | complex hyperbolic quadric; ruled real hypersurface; singular vector fields; η-commuting shape operator; η-parallel shape operator | English | 2023 | 2023-12-19 | 10.1515/dema-2023-0258 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Single-Benzene Dual-Emitters Harness Excited-State Antiaromaticity for White Light Generation and Fluorescence Imaging | Molecular emitters simultaneously generating light at different wavelengths have wide applications. With a small molecule, however, it is challenging to realize two independent radiative pathways. We invented the first examples of dual-emissive single-benzene fluorophores (SBFs). Two emissive tautomers are generated by synthetic modulation of the hydrogen bond acidity, which opens up pathways for excited-state proton transfer. White light is produced by a delicate balance between the energy and intensity of the emission from each tautomer. We show that the excited-state antiaromaticity of the benzene core itself dictates the proton movements driving the tautomer equilibrium. Using this simple benzene platform, a fluorinated SBF was synthesized with a record high solubility in perfluorocarbon solvents. White light-emitting devices and multicolor imaging of perfluorocarbon nanodroplets in live cells demonstrate the practical utility of these molecules. | Kim, Younghun; Kim, Heechan; Son, Jung Bae; Filatov, Michael; Choi, Cheol Ho; Lee, Nam Ki; Lee, Dongwhan | Seoul Natl Univ, Dept Chem, 1 Gwanak Ro, Seoul 08826, South Korea; Kyungpook Natl Univ, Dept Chem, 80 Daehak Ro, Daegu 41566, South Korea | ; Choi, Cheol Ho/AAA-4705-2020 | 55548794400; 57213118053; 57195808798; 7005134246; 7402958948; 36175135900; 55619306281 | namkilee@snu.ac.kr;dongwhan@snu.ac.kr; | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | ANGEW CHEM INT EDIT | 1433-7851 | 1521-3773 | 62 | 20 | SCIE | CHEMISTRY, MULTIDISCIPLINARY | 2023 | 16.1 | 5.8 | 2.77 | 2025-06-25 | 31 | 35 | Aromaticity; Fluorescence; Hydrogen Bonds; Materials Science; Photochemistry | INTRAMOLECULAR PROTON-TRANSFER; ORGANIC-MOLECULE; SOLID-STATE; EMISSION; AROMATICITY; RESONANCE; COMPOUND; SHIFT | Aromaticity; Fluorescence; Hydrogen Bonds; Materials Science; Photochemistry | Excited states; Fluorescence imaging; Hydrogen bonds; Molecules; Antiaromaticity; Aromaticities; Bond acidity; Excited-states; Fluorescence imaging; Material science; Molecular emitters; Perfluorocarbons; Small molecules; White-light generation; Benzene | English | 2023 | 2023-05-08 | 10.1002/anie.202302107 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | The role of acetone-fractionated Kraft lignin molecular structure on surface adhesion to formaldehyde-based resins | One of the key strategies for valorizing kraft lignin (KL) into value-added products such as bio-based adhesives is to perform solvent fractionation of KL to produce lignin with improved homogeneity. Understanding the structure and properties of fractionated KL will aid in the selection of the best samples for certain applications. In this study, acetone-fractionated KL from softwood and hardwood was characterized to understand its chemical structure, elemental composition, molecular weight, and thermal properties. The results revealed that acetone-insoluble KL (AIKL) fractions from softwood and hardwood have greater molecular weight, polydispersity, glass temperature, carbohydrate content, aliphatic hydroxyl groups, and a variety of native wood lignin side chains. In contrast, acetone-soluble KL (ASKL) fractions have a significantly lower molecular weight and polydispersity, a lower glass-transition temperature, a more condensed structure, more aromatic hydroxyl groups, and fewer native wood lignin side chains. In addition, the ASKL samples demonstrated stronger adhesive force and work of adhesion toward phenol-formaldehyde (PF) and urea-formaldehyde (UF) resins than the AIKL samples, regardless of the lignin source. These findings suggest that ASKL has great potential as a substitute for phenol in PF resins and as a green additive to reinforce UF resins. | Wibowo, Eko Setio; Park, Byung-Dae | Kyungpook Natl Univ, Dept Wood & Paper Sci, Daegu 41566, South Korea | Wibowo, Eko/AAL-5888-2021; Park, Byung-Dae/ABB-1934-2020 | 57214910272; 7402834820 | byungdae@knu.ac.kr; | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | INT J BIOL MACROMOL | 0141-8130 | 1879-0003 | 225 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, APPLIED;POLYMER SCIENCE | 2023 | 7.7 | 5.8 | 3.53 | 2025-06-25 | 24 | 30 | Softwood; Hardwood; Kraft lignin; Acetone fractionation; Lignin characterization; Adhesion; Formaldehyde-based resins | PHENOL; HARDWOOD; SOLVENT | Acetone fractionation; Adhesion; Formaldehyde-based resins; Hardwood; Kraft lignin; Lignin characterization; Softwood | Acetone; Adhesives; Formaldehyde; Lignin; Molecular Structure; Phenol; Phenols; acetone; adhesive agent; carbohydrate; formaldehyde; glass; lignin; phenol; resin; urea; formaldehyde; Kraft lignin; phenol derivative; Article; atomic force microscopy; biomass; carbon nuclear magnetic resonance; chemical structure; differential scanning calorimetry; dispersity; fractionation; heteronuclear single quantum coherence; molecular weight; phosphorus nuclear magnetic resonance; proton nuclear magnetic resonance; refraction index; surface property; surface tension; synthesis; temperature; thermostability; X ray diffraction; chemical structure; chemistry | English | 2023 | 2023-01-15 | 10.1016/j.ijbiomac.2022.11.202 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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