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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | On the fluorescence enhancement of arch neuronal optogenetic reporters | The lack of a theory capable of connecting the amino acid sequence of a light-absorbing protein with its fluorescence brightness is hampering the development of tools for understanding neuronal communications. Here we demonstrate that a theory can be established by constructing quantum chemical models of a set of Archaerhodopsin reporters in their electronically excited state. We found that the experimentally observed increase in fluorescence quantum yield is proportional to the computed decrease in energy difference between the fluorescent state and a nearby photoisomerization channel leading to an exotic diradical of the protein chromophore. This finding will ultimately support the development of technologies for searching novel fluorescent rhodopsin variants and unveil electrostatic changes that make light emission brighter and brighter. Arch-3 rhodopsin variants are common fluorescent reporters of neuronal activity. Here, the authors show with quantum chemical modelling that a set of these proteins reveals a direct proportionality between their observed fluorescence intensity and the stability of an exotic excited-state diradical intermediate. | Barneschi, Leonardo; Marsili, Emanuele; Pedraza-Gonzalez, Laura; Padula, Daniele; De Vico, Luca; Kaliakin, Danil; Blanco-Gonzalez, Alejandro; Ferre, Nicolas; Huix-Rotllant, Miquel; Filatov, Michael; Olivucci, Massimo | Univ Siena, Dipartimento Biotecnol Chim & Farm, Via A Moro 2, I-53100 Siena, Italy; Univ Durham, Dept Chem, South Rd, Durham DH1 3LE, England; Bowling Green State Univ, Dept Chem, Bowling Green, OH 43403 USA; Aix Marseille Univ, CNRS, UMR 7273, Inst Chim Radicalaire, F-13397 Marseille 20, France; Kyungpook Natl Univ, Dept Chem, Daegu 702701, South Korea; Univ Strasbourg, Inst Adv Studies, 5 Allee DuGen Er Al Rouvillois, F-67083 Strasbourg, France; Univ Bristol, Ctr Computat Chem, Sch Chem, Bristol BS8 1TS, Avon, England; Univ Pisa, Dipartimento Chim & Chim Ind, Via Giuseppe Moruzzi 13, I-56124 Pisa, Italy | ; OLIVUCCI, MASSIMO/O-2588-2019; Kaliakin, Danil/L-4713-2019; De Vico, Luca/HFZ-7775-2022; Blanco-Gonzalez, Alejandro/IQV-8363-2023; De Vico, Luca/D-2267-2009; Ferré, Nicolas/K-8228-2012; Padula, Daniele/F-2866-2012; Pedraza-González, Laura/JMB-1212-2023; Huix-Rotllant, Miquel/J-3291-2016 | 57301013500; 57207302695; 57191512673; 24463809800; 6507269968; 56517000800; 57221253472; 7003305008; 25634188900; 7005134246; 7005041141 | olivucci@unisi.it; | NATURE COMMUNICATIONS | NAT COMMUN | 2041-1723 | 13 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 16.6 | 7.5 | 1.23 | 2025-06-25 | 17 | 19 | ALL-OPTICAL ELECTROPHYSIOLOGY; VOLTAGE; RHODOPSINS; MECHANISM; EVOLUTION; PROTEIN | Fluorescence; Models, Chemical; Optogenetics; Quantum Theory; Rhodopsin; Static Electricity; rhodopsin; rhodopsin; amino acid; fluorescence; neurology; photochemistry; protein; amino acid sequence; Article; calculation; chemical model; chromatophore; diffusion; fluorescence; isomerization; optogenetics; quantum chemistry; quantum yield; reporter gene; simulation; static electricity; surface property; topography; chemical model; chemistry; fluorescence; quantum theory | English | 2022 | 2022-10-28 | 10.1038/s41467-022-33993-4 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Photosynthetic microbial fuel cells for methanol treatment using graphene electrodes | Photosynthetic microbial fuel cells (pMFC) represent a promising approach for treating methanol (CH3OH) wastewater. However, their use is constrained by a lack of knowledge on the extracellular electron transfer capabilities of photosynthetic methylotrophs, especially when coupled with metal electrodes. This study assessed the CH3OH oxidation capabilities of Rhodobacter sphaeroides 2.4.1 in two-compartment pMFCs. A 3D nickel (Ni) foam modified with plasma-grown graphene (Gr) was used as an anode, nitrate mineral salts media (NMS) supplemented with 0.1% CH3OH as anolyte, carbon brush as cathode, and 50 mM ferricyanide as catholyte. Two simultaneous pMFCs that used bare Ni foam and carbon felt served as controls. The Ni/Gr electrode registered a two-fold lower charge transfer resistance (0.005 k omega cm2) and correspondingly 16-fold higher power density (141 mW/m2) compared to controls. The underlying reasons for the enhanced performance of R. sphaeroides at the graphene interface were discerned. The real-time polymerase chain reaction (PCR) analysis revealed the upregulation of cytochrome c oxidase, aa3 type, subunit I gene, and Flp pilus assembly protein genes in the sessile cells compared to their planktonic counterparts. The key EET pathways used for sustaining CH3OH oxidation were discussed. | Jawaharraj, Kalimuthu; Sigdel, Pawan; Gu, Zhengrong; Muthusamy, Govarthanan; Sani, Rajesh Kumar; Gadhamshetty, Venkataramana | Civil & Environm Engn, South Dakota Mines, 501 E St Joseph St, Rapid City, SD 57701 USA; South Dakota Mines, Chem & Biol Engn, 501 E St Joseph St, Rapid City, SD 57701 USA; South Dakota Mines, BuG ReMeDEE Consortia, 501 E St Joseph St, Rapid City, SD 57701 USA; South Dakota State Univ, Agr & Biosyst Engn, Univ Stn 2100, Brookings, SD 57701 USA; Kyungpook Natl Univ, Dept Environm Engn, 80 Daehak Ro, Daegu, South Korea; Sci & Technol 2DBEST Ctr, South Dakota Mines, 2D Mat Biofilm Engn, 2D-Mat Biofilm Engn, 501 E St Joseph St, Rapid City, SD 57701 USA; Data Driven Mat Discovery Bioengn Innovat Ctr, South Dakota Mines, 501 E St Joseph St, Rapid City, SD 57701 USA; Saveetha Inst Med & Tech Sci, Saveetha Dent Coll & Hospital, Dept Biomat, Chennai 600077, Tamil Nadu, India; South Dakota Mines, Dept Civil & Environm Engn, 501 St Joseph St, Rapid City, SD 57701 USA | Gu, Jimmy/N-4439-2019; Muthusamy, Govarthanan/C-1491-2014; Govarthanan, Muthusamy/C-1491-2014 | 56711998600; 56560102700; 55005801500; 54881927600; 7005555107; 57203474187 | Venkata.Gadhamshetty@sdsmt.edu; | ENVIRONMENTAL RESEARCH | ENVIRON RES | 0013-9351 | 1096-0953 | 215 | SCIE | ENVIRONMENTAL SCIENCES;PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | 2022 | 8.3 | 7.5 | 0.91 | 2025-06-25 | 12 | 12 | Graphene; Methanol; Rhodobacter; Photosynthetic; Microbial fuel cells | RHODOBACTER-SPHAEROIDES 2.4.1; ONEIDENSIS MR-1 BIOFILM; 3-DIMENSIONAL GRAPHENE; PERFORMANCE; METABOLISM; EXPRESSION; PROTEINS; ANODE; FOAM | Graphene; Methanol; Microbial fuel cells; Photosynthetic; Rhodobacter | Bioelectric Energy Sources; Carbon; Carbon Fiber; Electrodes; Electron Transport Complex IV; Ferricyanides; Graphite; Methanol; Nickel; Nitrates; Salts; Waste Water; carbon; carbon fiber; cytochrome c oxidase; ferricyanide; graphite; inorganic salt; methanol; nickel; nitric acid derivative; cytochrome; electron; fuel cell; methanol; microbial activity; nickel; nitrate; oxidation; photosynthesis; polymerase chain reaction; protein; bioenergy; electrode; wastewater | English | 2022 | 2022-12 | 10.1016/j.envres.2022.114045 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Quantum transport evidence of isolated topological nodal-line fermions | Anomalous transport responses, dictated by the nontrivial band topology, are the key for application of topological materials to advanced electronics and spintronics. One promising platform is topological nodal-line semimetals due to their rich topology and exotic physical properties. However, their transport signatures have often been masked by the complexity in band crossings or the coexisting topologically trivial states. Here we show that, in slightly hole-doped SrAs3, the single-loop nodal-line states are well-isolated from the trivial states and entirely determine the transport responses. The characteristic torus-shaped Fermi surface and the associated encircling Berry flux of nodal-line fermions are clearly manifested by quantum oscillations of the magnetotransport properties and the quantum interference effect resulting in the two-dimensional behaviors of weak antilocalization. These unique quantum transport signatures make the isolated nodal-line fermions in SrAs3 desirable for novel devices based on their topological charge and spin transport. Clear electronic transport signatures of topological nodal-line semimetals have been lacking due to their complex electronic structure and the presence of topologically trivial states. Kim et al. demonstrate that the quantum transport response in slightly hole-doped SrAs3 is dominated by nodal-line fermions. | Kim, Hoil; Ok, Jong Mok; Cha, Seyeong; Jang, Bo Gyu; Kwon, Chang Il; Kohama, Yoshimitsu; Kindo, Koichi; Cho, Won Joon; Choi, Eun Sang; Jo, Youn Jung; Kang, Woun; Shim, Ji Hoon; Kim, Keun Su; Kim, Jun Sung | Inst Basic Sci IBS, Ctr Artificial Low Dimens Elect Syst, Pohang 37673, South Korea; Pohang Univ Sci & Technol POSTECH, Dept Phys, Pohang 37673, South Korea; Pusan Natl Univ, Dept Phys, Busan 46241, South Korea; Yonsei Univ, Dept Phys, Seoul 03722, South Korea; Pohang Univ Sci & Technol POSTECH, Dept Chem, Pohang 37673, South Korea; Univ Tokyo, Lnstitute Solid State Phys, Kashiwa, Chiba 2778581, Japan; Samsung Elect Co Ltd, Mat Res Ctr, Samsung Adv Inst Technol SAIT, Suwon 16678, Gyeonggi Do, South Korea; Florida State Univ, Natl High Magnet Field Lab, Tallahassee, FL 32310 USA; Kyungpook Natl Univ, Dept Phys, Daegu, South Korea; Ewha Womans Univ, Thepartment Phys, Seoul 03760, South Korea | ; Kohama, Yoshimitsu/AAF-3281-2020; Kim, Jun/G-8861-2012; Jang, Bo Gyu/AFK-3500-2022; Kim, Jun-Seob/O-5275-2019 | 57194533632; 55744462900; 57220747647; 56708132800; 56468847000; 13004637000; 7006020484; 57646757200; 7402121894; 13502586500; 7202402145; 57281457100; 56517053900; 50061571500 | js.kim@postech.ac.kr; | NATURE COMMUNICATIONS | NAT COMMUN | 2041-1723 | 13 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 16.6 | 7.5 | 0.69 | 2025-06-25 | 10 | 10 | MAGNETORESISTANCE; SRAS3; SPIN | complexity; physical property; topology; article; berry; fermion; oscillation | English | 2022 | 2022-11-23 | 10.1038/s41467-022-34845-x | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article; Retracted Publication | RETRACTED: Intimately coupled gC3N4 photocatalysis and mixed culture biofilm enhanced detoxification of sulfamethoxazole: Elucidating degradation mechanism and toxicity assessment (Retracted article. See vol. 275, 2025) | In recent years, wide spread of antibiotic-resistant microorganisms and genes emerging globally, an eco-friendly method for efficient degradation of antibiotics from the polluted environment is essential. Intimately coupled photocatalysis and biodegradation (ICPB) using gC3N4 for enhanced degradation of sulfamethoxazole (SMX) was investigated. The gC3N4 were prepared and coated on the carbon felt. The mixed culture biofilm was developed on the surface as a biocarrier. The photocatalytic degradation showed 74%, and ICPB exhibited 95% SMX degradation efficiency. ICPB showed superior visible light adsorption, photocatalytic activity, and reduced charge recombination. The electron paramagnetic resonance spectrum confirms that the generation of center dot OH and O2 center dot radicals actively participated in the degradation of SMX into biodegradable intermediated compounds, and then, the bacterial communities present in the biofilm mineralized the biodegradable compound into carbon dioxide and water. Moreover, the addition of NO3-, PO4-, and Cl- significantly enhanced the degradation efficiency by trapping the surface electron. Stability experiments confirmed that gC3N4 biohybrid can maintain 85% SMX degradation efficiency after 5 consecutive recycling. Extracellular polymeric substances characterization results show that biohybrid contains 47 mg/L, 14 mg/L, and 13 mg/L protein, carbohydrate, and humic acid, respectively, which can protect the bacterial communities from the antibiotic toxicity and reactive oxygen species. Furthermore, biotoxicity was investigated using degradation products on E.coli and results revealed 83% detoxification efficiency. Overall, this study suggested that gC3N4 photocatalyst in an ICPB can be used as a promising eco-friendly method to degrade sulfamethoxazole efficiently. | Sathishkumar, Kuppusamy; Kannan, Velu Rajesh; Alsalhi, Mohamad S.; Rajasekar, Aruliah; Devanesan, Sandhanasamy; Narenkumar, Jayaraman; Kim, Woong; Liu, Xinghui | Yanan Univ, Sch Phys & Elect Informat, Yanan 716000, Peoples R China; Bharathidasan Univ, Dept Microbiol, Rhizosphere Biol Lab, Tiruchirappalli 620 024, Tamil Nadu, India; King Saud Univ, Coll Sci, Dept Phys & Astron, Riyadh 11451, Saudi Arabia; Thiruvalluvar Univ, Dept Biotechnol, Environm Mol Microbiol Res Lab, Vellore 632 115, Tamil Nadu, India; Bharath Inst Higher Educ & Res, Ctr Mat Engn & Regenerat Med, Chennai 600073, Tamil Nadu, India; Kyungpook Natl Univ, Dept Environm Engn, Daegu, South Korea; Sungkyunkwan Univ SKKU, Dept Chem, 2066 Seoburo, Suwon 16419, South Korea | ; Liu, Xinghui/GOP-0490-2022; alsalhi, mohamad/M-5013-2019; Jayaraman, Narenkumar/JGD-7456-2023; Devanesan, Sandhanasamy/ABH-3378-2021; Devanesan, Dr. Sandhanasamy/ABH-3378-2021; Aruliah, Rajasekar/E-4568-2015 | 57192713219; 59311557000; 10440259800; 55928874800; 55279721800; 57194229197; 55581636400; 57206739900 | ksathish570@gmail.com;liuxinghui119@gmail.com; | ENVIRONMENTAL RESEARCH | ENVIRON RES | 0013-9351 | 1096-0953 | 214 | SCIE | ENVIRONMENTAL SCIENCES;PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | 2022 | 8.3 | 7.5 | 1.78 | 2025-06-25 | 18 | 16 | Antibiotic; Sulfamethoxazole; Photocatalyst; Biodegradation; Biotoxicity | EXTRACELLULAR POLYMERIC SUBSTANCES; WASTE-WATER; BIODEGRADATION; MINERALIZATION; G-C3N4/TIO2; TIO2; OXIDATION; LIFE | Antibiotic; Biodegradation; Biotoxicity; Photocatalyst; Sulfamethoxazole | Anti-Bacterial Agents; Bacteria; Biodegradation, Environmental; Biofilms; Sulfamethoxazole; Titanium; Antibiotics; Biofilms; Carbon dioxide; Degradation; Detoxification; Efficiency; Electron spin resonance spectroscopy; Environmental protection; Escherichia coli; Paramagnetic resonance; Photocatalytic activity; ammonia; antibiotic agent; carbohydrate; carbon; carbon dioxide; graphite; humic acid; nitrate; oxygen; phosphate; phosphorus; radical; sulfamethoxazole; water; antiinfective agent; titanium; Bacterial community; Bio-hybrids; Biotoxicity; Degradation efficiency; Degradation mechanism; Eco-friendly; Mixed cultures; Sulfamethoxazole; Toxicity assessment; Wide spreads; antibiotics; biodegradation; biofilm; carbon dioxide; catalysis; catalyst; drug; microbial activity; microbial community; toxicity; Article; biodegradation; biofilm; detoxification; electron spin resonance; energy dispersive X ray spectroscopy; Escherichia coli; Fourier transform infrared spectroscopy; microbial community; mixed cell culture; photocatalysis; photodegradation; polymerization; scanning electron microscopy; X ray diffraction; bacterium; bioremediation; Biodegradation | English | 2022 | 2022-11 | 10.1016/j.envres.2022.113824 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Self-evolving vision transformer for chest X-ray diagnosis through knowledge distillation | Although deep learning-based computer-aided diagnosis systems have recently achieved expert-level performance, developing a robust model requires large, high-quality data with annotations that are expensive to obtain. This situation poses a conundrum that annually-collected chest x-rays cannot be utilized due to the absence of labels, especially in deprived areas. In this study, we present a framework named distillation for self-supervision and self-train learning (DISTL) inspired by the learning process of the radiologists, which can improve the performance of vision transformer simultaneously with self-supervision and self-training through knowledge distillation. In external validation from three hospitals for diagnosis of tuberculosis, pneumothorax, and COVID-19, DISTL offers gradually improved performance as the amount of unlabeled data increase, even better than the fully supervised model with the same amount of labeled data. We additionally show that the model obtained with DISTL is robust to various real-world nuisances, offering better applicability in clinical setting. Although deep learning-based computer-aided diagnosis systems have recently achieved expert level performance, developing a robust model requires large, high-quality data with annotations. Here, the authors present a framework which can improve the performance of vision transformer simultaneously with self-supervision and self-training. | Park, Sangjoon; Kim, Gwanghyun; Oh, Yujin; Seo, Joon Beom; Lee, Sang Min; Kim, Jin Hwan; Moon, Sungjun; Lim, Jae-Kwang; Park, Chang Min; Ye, Jong Chul | Korea Adv Inst Sci & Technol, Dept Bio & Brain Engn, Daejeon, South Korea; Univ Ulsan, Asan Med Ctr, Coll Med, Seoul, South Korea; Chungnam Natl Univ, Coll Med, Daejeon, South Korea; Yeungnam Univ, Coll Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Daegu, South Korea; Seoul Natl Univ, Coll Med, Seoul, South Korea; Korea Adv Inst Sci & Technol, Kim Jaechul Grad Sch AI, Daejeon, South Korea | ; Oh, Yujin/ABG-2034-2020; Lee, Sang/ABC-8385-2020; Ye, Jong/C-1623-2011; Park, Chang/J-8409-2016 | 57211828373; 57222871620; 57218407478; 55512425800; 58097828800; 55910532600; 57189891980; 55515341400; 16234023200; 7403237499 | jong.ye@kaist.ac.kr; | NATURE COMMUNICATIONS | NAT COMMUN | 2041-1723 | 13 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 16.6 | 7.5 | 3.15 | 2025-06-25 | 38 | 46 | TUBERCULOSIS | Algorithms; COVID-19; Diagnosis, Computer-Assisted; Humans; Radiography; X-Rays; distillation; knowledge; learning; vision; X-ray; Article; cohort analysis; controlled study; convolutional neural network; coronavirus disease 2019; distillation for self supervision and self train learning; external validity; hospital; human; laboratory test; machine learning; pneumothorax; radiologist; residual neural network; supervised machine learning; thorax radiography; tuberculosis; algorithm; computer assisted diagnosis; diagnostic imaging; radiography; X ray | English | 2022 | 2022-07-04 | 10.1038/s41467-022-31514-x | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Super-hydration and reduction of manganese oxide minerals at shallow terrestrial depths | Manganese oxides are ubiquitous marine minerals which are redox sensitive. As major components of manganese nodules found on the ocean floor, birnessite and buserite have been known to be two distinct water-containing minerals with manganese octahedral interlayer separations of similar to 7 angstrom and similar to 10 angstrom, respectively. We show here that buserite is a super-hydrated birnessite formed near 5 km depth conditions. As one of the most hydrous minerals containing ca. 34.5 wt. % water, super-hydrated birnessite, i.e., buserite, remains stable up to ca. 70 km depth conditions, where it transforms into manganite by releasing ca. 24.3 wt. % water. Subsequent transformations to hausmannite and pyrochroite occur near 100 km and 120 km depths, respectively, concomitant with a progressive reduction of Mn4+ to Mn2+. Our work forwards an abiotic geochemical cycle of manganese minerals in subduction and/or other aqueous terrestrial environments, with implications for water storage and cycling, and the redox capacity of the region. | Yun, Seohee; Hwang, Huijeong; Hwang, Gilchan; Kim, Yeongkyoo; Blom, Douglas; Vogt, Thomas; Post, Jeffrey E.; Jeon, Tae-Yeol; Shin, Tae Joo; Zhang, Dong-Zhou; Kagi, Hiroyuki; Lee, Yongjae | Yonsei Univ, Dept Earth Syst Sci, Seoul 03722, South Korea; Kyungpook Natl Univ, Sch Earth Syst Sci, Daegu 41566, South Korea; Univ South Carolina, Nano Ctr, Columbia, SC 29208 USA; Univ South Carolina, Dept Chem Engn, Columbia, SC 29208 USA; Univ South Carolina, Nano Ctr, Dept Chem & Biochem, Columbia, SC 29208 USA; Univ South Carolina, Nano Ctr, Dept Chem Engn, Columbia, SC 29208 USA; Smithsonian Inst, Dept Mineral Sci, Washington, DC 20013 USA; Pohang Accelerator Lab, Beamline Sci Div, Pohang 37673, South Korea; UNIST, Grad Sch Semicond Mat & Devices Engn, Ulsan 44919, South Korea; Univ Hawaii Manoa, Hawaii Inst Geophys & Planetol, 9700S Cass Ave, Argonne, IL 60439 USA; Univ Tokyo, Geochem Res Ctr, Grad Sch Sci, Bunkyo Ku, Hongo 7-3-1, Tokyo 1130033, Japan; GIST, Sch Earth Sci & Environm Engn, Gwangju 61005, South Korea | Zhang, Dongzhou/D-9604-2017; Hwang, Gil/E-6811-2019; Shin, Tae/R-7434-2016; Dongzhou, Zhang/W-1896-2019; Shin, Tae Joo/R-7434-2016; Blom, Douglas/A-6122-2012; Hwang, Gil Chan/E-6811-2019; Vogt, Thomas/A-1562-2011 | 57404826800; 58254883100; 24168338500; 7410207179; 7005939637; 7202069869; 7202175950; 24824708200; 7201493153; 54397871200; 7003380094; 8063814500 | yongjaelee@yonsei.ac.kr; | NATURE COMMUNICATIONS | NAT COMMUN | 2041-1723 | 13 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 16.6 | 7.5 | 0.89 | 2025-06-25 | 13 | 13 | TODOROKITE BUSERITE PROBLEM; POWDER DIFFRACTION; GALE CRATER; BIRNESSITE; WATER; METAL; KAOLINITE; OXIDATION; THALLIUM; SEDIMENT | manganese; manganese oxide; oxygen; geochemical cycle; hydration; manganese oxide; reduction; water storage; anisotropy; Article; cell volume; chemical structure; controlled study; cycling; data availability; earthquake; hydration; room temperature; scanning electron microscopy; subduction; subduction zone; X ray diffraction; X ray powder diffraction | English | 2022 | 2022-04-11 | 10.1038/s41467-022-29328-y | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Synthesis, performance, and mechanisms of strontium ferrite-incorporated zeolite imidazole framework (ZIF-8) for the simultaneous removal of Pb(II) and tetracycline | In this study, strontium ferrite (SF)-incorporated zeolite imidazole framework (ZIF-8) (SFZIF-8) that can simultaneously uptake Pb(II) and tetracycline (TC) in solution was synthesized and characterized. The physicochemical properties of the as-prepared SFZIF-8 were characterized by various functional groups, higher average pore diameter (3.414 nm), and stronger negative charge (-30.5 mV). Adsorption kinetics, isotherms, effect of various water conditions including solution pH and temperature, and reusability were studied to evaluate its adsorption performance. The adsorption capacity of SFZIF-8 was compared with that of commonly used adsorbents (powder and granular activated carbon). SFZIF-8 showed much higher adsorption performance (429.6 mg/g and 433.4 mg/g for Pb(II) and TC, respectively) than powder activated carbon (129.9 mg/g and 142.0 mg/g for Pb(II) and TC, respectively) and granular activated carbon (249.3 mg/g and 263.0 mg/g for Pb (II) and TC, respectively) in Pb(II) and TC binary solutions. The SFZIF-8 adsorption behaviors for the removal of Pb(II) and TC were explained by the pseudo-first-order and Langmuir models from the adsorption kinetics and isotherm experiments, respectively. The regenerated SFZIF-8 exhibited a competitive performance even after the third cycle. These results indicate that Pb(II) and TC can be removed with SFZIF-8 via electrostatic attraction, surface complexation, hydrogen bonding, and 7C-7C interactions. Therefore, by exhibiting effective and efficient adsorption performance, SFZIF-8 nanocomposites can be utilized as alternative and promising adsorbents for the simultaneous removal of both Pb(II) and TC. | Kim, Gyuri; Yea, Yeonji; Njaramba, Lewis Kamande; Yoon, Yeomin; Kim, Sewoon; Park, Chang Min | Kyungpook Natl Univ, Dept Environm Engn, 80 Daehak Ro, Daegu 41566, South Korea; Univ South Carolina, Dept Civil & Environm Engn, 300 Main St, Columbia, SC 29208 USA; Univ Iowa, Dept Civil & Environm Engn, Iowa City, IA 52242 USA | ; Yoon, Yeomin/KDP-2253-2024; Park, Chang Min/CAA-8506-2022; Kamande, Lewis/JLL-5435-2023 | 57222585103; 57217304205; 57223183206; 7402126688; 57201422323; 57209588953 | riri97@naver.com;dpduswl@naver.com;lewiskamande@gmail.com;yoony@cec.sc.edu;Sewoonkim@uiowa.edu;cmpark@knu.ac.kr;sewoon-kim@uiowa.edu; | ENVIRONMENTAL RESEARCH | ENVIRON RES | 0013-9351 | 1096-0953 | 212 | SCIE | ENVIRONMENTAL SCIENCES;PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | 2022 | 8.3 | 7.5 | 0.84 | 2025-06-25 | 11 | 11 | Strontium ferrite; Zeolite imidazole framework; Lead; Tetracycline; Adsorption | AQUEOUS-SOLUTION; WASTE-WATER; IN-SITU; PHOTOCATALYTIC DEGRADATION; ADSORPTION MECHANISM; RECYCLABLE ADSORBENT; MAGNESIUM-HYDROXIDE; SORBENT SYNTHESIS; METAL-IONS; ANTIBIOTICS | Adsorption; Lead; Strontium ferrite; Tetracycline; Zeolite imidazole framework | Adsorption; Anti-Bacterial Agents; Charcoal; Ferric Compounds; Hydrogen-Ion Concentration; Imidazoles; Kinetics; Lead; Powders; Strontium; Tetracycline; Water Pollutants, Chemical; Zeolites; activated carbon; adsorbent; anionic surfactant; dodecyl sulfate sodium; ferric hydroxide; ferrite; imidazole derivative; lead; nanocomposite; strontium; tetracycline; zeolite; antiinfective agent; charcoal; ferric ion; ferrite; imidazole derivative; lead; strontium; tetracycline; activated carbon; antibiotics; ferrite; lead; performance assessment; pollutant removal; strontium; zeolite; adsorption kinetics; Article; chemical interaction; crystal structure; desorption; diffraction; field emission scanning electron microscopy; Fourier transform infrared spectroscopy; heavy metal removal; hydrogen bond; isotherm; magnetism; morphology; pH; physical chemistry; pore size; pore size distribution; pore volume; powder; reaction temperature; static electricity; surface charge; surface property; texture analysis; thermostability; vibration; waste water management; water quality; water temperature; zeta potential; adsorption; chemistry; kinetics; water pollutant | English | 2022 | 2022-09 | 10.1016/j.envres.2022.113419 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Towards the engineering of a photon-only two-stroke rotary molecular motor | The rational engineering of photoresponsive materials, e.g., light-driven molecular motors, is a challenging task. Here, we use structure-related design rules to prepare a prototype molecular rotary motor capable of completing an entire revolution using, exclusively, the sequential absorption of two photons; i.e., a photon-only two-stroke motor. The mechanism of rotation is then characterised using a combination of non-adiabatic dynamics simulations and transient absorption spectroscopy measurements. The results show that the rotor moiety rotates axially relative to the stator and produces, within a few picoseconds at ambient T, an intermediate with the same helicity as the starting structure. We discuss how such properties, that include a 0.25 quantum efficiency, can help overcome the operational limitations of the classical overcrowded alkene designs. Improving the efficiency of light-driven molecular rotary motors is a challenging task. Here, the authors combine theoretical modeling, synthesis and spectroscopy to prepare a prototype molecular motor capable of avoiding inefficient thermally activated motion; thus offering prospects to implement a 2-stroke photon-only molecular motor. | Filatov, Michael; Paolino, Marco; Pierron, Robin; Cappelli, Andrea; Giorgi, Gianluca; Leonard, Jeremie; Huix-Rotllant, Miquel; Ferre, Nicolas; Yang, Xuchun; Kaliakin, Danil; Blanco-Gonzalez, Alejandro; Olivucci, Massimo | Kyungpook Natl Univ, Dept Chem, Daegu 702701, South Korea; Univ Siena, Dipartimento Biotecnol Chim & Farm, Via A Moro 2, I-53100 Siena, Italy; Univ Strasbourg, CNRS UMR 7504, Inst Phys & Chim Mat Strasbourg, Strasbourg, France; Aix Marseille Univ, CNRS, Inst Chim Radicalaire UMR 7273, F-13397 Marseille 20, France; Bowling Green State Univ, Chem Dept, Overmann Hall, Bowling Green, OH 43403 USA | ; OLIVUCCI, MASSIMO/O-2588-2019; Pierron, Robin/J-6561-2017; Huix-Rotllant, Miquel/J-3291-2016; Kaliakin, Danil/L-4713-2019; Ferré, Nicolas/K-8228-2012; Blanco-Gonzalez, Alejandro/IQV-8363-2023 | 57771160500; 36464128000; 57193201397; 7006976300; 7102507767; 7402283467; 25634188900; 7003305008; 55683795400; 56517000800; 57221253472; 7005041141 | mike.filatov@gmail.com;paolino3@unisi.it;massimo.olivucci@unisi.it;jeremie.leonard@ipcms.unistra.fr; | NATURE COMMUNICATIONS | NAT COMMUN | 2041-1723 | 13 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 16.6 | 7.5 | 2.12 | 2025-06-25 | 31 | 31 | DENSITY-FUNCTIONAL THEORY; REFERENCED KOHN-SHAM; FRACTIONALLY OCCUPIED STATES; UNIDIRECTIONAL ROTATION; CONICAL INTERSECTIONS; DYNAMICS; PHOTOISOMERIZATION; SPEED; ENSEMBLES; ENERGIES | Humans; Photons; Rotation; Stroke; alkene; molecular motor; alkene; atomic absorption spectroscopy; design; molecular analysis; absorption; adiabaticity; Article; calculation; chemical bond; chemical structure; comparative study; diastereoisomer; enantiomer; engineering; excitation; gas; isomer; photochemistry; photon; population dynamics; quantum mechanics; rotation; simulation; steady state; surface property; synthesis; transient absorption spectroscopy; validity; X ray crystallography; cerebrovascular accident; human; rotation | English | 2022 | 2022-10-28 | 10.1038/s41467-022-33695-x | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Tunable fluorescent carbon dots from biowaste as fluorescence ink and imaging human normal and cancer cells | Growing global biowaste and its environmental issues challenge the need for converting biowastes into a beneficial product. Among the biowaste, here kiwi fruit (Actinidia Deliciosa) peels are considered for the preparation of carbon dots (CDs). Using a green one-pot hydrothermal-carbonization method, kiwi fruit peels were effectively converted into valuable kiwi fruit peel carbon dots (KFP-CDs). The morphology, physio-chemical and optical properties of as-synthesized KFP-CDs were analyzed using various analytical techniques such as X-ray powder diffraction, Raman spectroscopy, attenuated total reflection-Fourier transform infrared spectroscopy, field emission scanning electron microscopy, high-resolution transmission electron microscopy, X-ray photoelectron spectroscopy, Ultraviolet-visible, and fluorescence spectroscopy. The KFP-CDs revealed a homogeneous spherical shape, monodispersed with an average size of 5 nm. The characterization confirms that KFP-CDs have functional groups such as -CN, -COOH, and -OH which are responsible for the easy dispersion of KFP-CDs in aqueous media. Without any preprocessing, KFP-CDs exhibit strong fluorescence upon exposure to UV light. Further, KFP-CDs displayed excitation-dependent fluorescence emission with a good quantum yield of about 18%. Thus by considering the excellent properties of KFP-CDs, KFP-CDs were used as fluorescent ink for drawing and writing without any capping/passivation agent. The pictures and words were instantaneously viewed when exposed to UV light. In addition, KFP-CDs tested for cell imaging in four human cell lines (normal and cancer cells) bestowed excellent biocompatibility and low cytotoxicity, which is important for the safe and long-term development of cellular imaging. The findings imply that KFP-CDs can be utilized as a cell labeling agent for mesenchymal stem cells, breast cancer, and thyroid cancer cells in vitro imaging. Thus, these observations revealed that investigating sustainable resource-based CDs can open up new avenues for tackling environmental issues. | Atchudan, Raji; Kishore, Somasundaram Chandra; Gangadaran, Prakash; Edison, Thomas Nesakumar Jebakumar Immanuel; Perumal, Suguna; Rajendran, Ramya Lakshmi; Alagan, Muthulakshmi; Al-Rashed, Sarah; Ahn, Byeong-Cheol; Lee, Yong Rok | Yeungnam Univ, Sch Chem Engn, Gyongsan 38541, South Korea; Saveetha Sch Engn, Saveetha Inst Med & Tech Sci, Dept Biomed Engn, Chennai 602105, Tamil Nadu, India; Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, BK21 FOUR KNU Convergence Educ Program Biomed Sci, Daegu 41944, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Nucl Med, Daegu 41944, South Korea; Univ Informat Sci & Technol St Paul Apostle, Fac Informat & Commun Sci, Ohrid, North Macedonia; King Saud Univ, Coll Sci, Dept Bot & Microbiol, PO 2455, Riyadh 11451, Saudi Arabia | ; Jebakumar Immanuel Edison, Thomas Nesakumar/N-8909-2015; Rajendran, Ramya/AAV-6338-2021; perumal, suguna/N-9075-2017; Gangadaran, Prakash/AAV-3102-2021; Lee, Yong/K-6373-2015; RAJI, ATCHUDAN/C-9904-2017; Al-Rashed, Sarah/MFI-6935-2025; s, chandra/AAG-3494-2019; Edison, Thomas/N-8909-2015 | 26648054700; 57192690551; 54393130400; 57210289891; 56673798900; 57195318729; 57219866585; 36969750400; 7202791511; 57330662900 | atchudanr@yu.ac.kr;yrlee@yu.ac.kr; | ENVIRONMENTAL RESEARCH | ENVIRON RES | 0013-9351 | 1096-0953 | 204 | SCIE | ENVIRONMENTAL SCIENCES;PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | 2022 | 8.3 | 7.5 | 11.71 | 2025-06-25 | 156 | 155 | Kiwi fruit peel; Hydrothermal route; Carbon dots; Fluorescence ink; Fluorescent probe; Cellular imaging | GRAPHENE QUANTUM DOTS; LARGE-SCALE SYNTHESIS; GREEN SYNTHESIS; FACILE SYNTHESIS; NANODOTS; PHOTOLUMINESCENCE; STATE; ION; PYROLYSIS; EVOLUTION | Carbon dots; Cellular imaging; Fluorescence ink; Fluorescent probe; Hydrothermal route; Kiwi fruit peel | Carbon; Humans; Ink; Neoplasms; Photoelectron Spectroscopy; Quantum Dots; Spectrometry, Fluorescence; carbon; fluorescent dye; carbon; ink; quantum dot; aqueous solution; cancer; cell; cell component; detection method; dispersion; imaging method; radiation exposure; ultraviolet radiation; Article; biocompatibility; breast cancer; cancer cell; cancer diagnosis; carbonization; cell culture; cell labeling; cell viability; cell viability assay; comparative study; confocal microscopy; controlled study; cytotoxicity; excitation; field emission scanning electron microscopy; fluorescence; Fourier transform infrared spectroscopy; fruit peel; high resolution transmission electron microscopy; human; human cell; in vitro study; kiwifruit; mesenchymal stem cell; nonhuman; quantum yield; Raman spectrometry; spectrofluorometry; thyroid cancer; ultraviolet radiation; ultraviolet visible spectrophotometry; X ray photoemission spectroscopy; X ray powder diffraction; chemistry; neoplasm; spectrofluorometry | English | 2022 | 2022-03 | 10.1016/j.envres.2021.112365 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Applicability of Control Materials To Support Gene Promoter Characterization and Expression in Engineered Cells Using Digital PCR | The use of standardized components and processes in engineering underpins the design-build-test model, and the engineering of biological systems is no different Substantial efforts to standardize both the components and the methods to validate the engineered biological systems is ongoing. This study has developed a panel of control materials encoding the commonly used reporter genes GFP and RFP as DNA or RNA molecules. Each panel contained up to six samples with increasingly small copy number differences between the two reporter genes that ranged from 1- to 2-fold differences. These copy number differences represent the magnitude of changes that may need to be measured to validate an engineered system. Using digital PCR (dPCR), we demonstrated that it is possible to quantify changes in both gene and gene transcript numbers both within and between samples down to 1.05-fold. We corroborated these findings using a simple gene circuit within a bacterial model to demonstrate that dPCR was able to precisely identify small changes in gene expression of two transcripts in response to promoter stimulation. Finally, we used our findings to highlight sources of error that can contributed to the measurement uncertainty in the measurement of small ratios in biological systems. Together, the development of a panel of control materials and validation of a high accuracy method for the measurement of small changes in gene expression, this study can contribute to the engineering biology "toolkit" of methods and materials to support the current standardization efforts. | Fernandez-Gonzalez, Ana; Cowen, Simon; Kim, Juhyun; Foy, Carole A.; Jimenez, Jose; Huggett, Jim F.; Whale, Alexandra S. | LGC, Natl Measurement Lab, Mol & Cell Biol Team, Teddington TW11 0LY, Middx, England; LGC, Stat Team, Teddington TW11 0LY, Middx, England; Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat BioRes Grp, Daegu 41566, South Korea; Imperial Coll London, Fac Nat Sci, Dept Life Sci, London SW7 2AZ, England; Univ Surrey, Fac Hlth & Med Sci, Sch Biosci & Med, Guildford GU5 7XH, Surrey, England | ; Huggett, Jim/N-9316-2013 | 57196233517; 7004007965; 55829164000; 56238519500; 15922896500; 36979844800; 55250637200 | alexandra.whale@lgcgroup.com; | ANALYTICAL CHEMISTRY | ANAL CHEM | 0003-2700 | 1520-6882 | 94 | 14 | SCIE | CHEMISTRY, ANALYTICAL | 2022 | 7.4 | 7.6 | 0.07 | 2025-06-25 | 1 | 1 | STANDARDIZATION; PUBLICATION; QPCR | Gene expression; Polymerase chain reaction; Uncertainty analysis; Control materials; Copy number; Design/build; DNA molecules; Gene promoter; Genes expression; Measurements of; Reporter gene; Standardized components; Test models; Biological systems | English | 2022 | 2022-04-12 | 10.1021/acs.analchem.1c05134 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Mediating effects of self-directed learning on the relationship between critical thinking and problem-solving in student nurses attending online classes: A cross-sectional descriptive study | Background: With the increased prevalence of online education due to the coronavirus 2019 pandemic and advancements in information technology, essential competencies, such as critical thinking, self-directed learning, and problem-solving ability, should be examined among student nurses taking online classes. Objectives: Based on the findings of several studies suggesting that critical thinking does not affect problem-solving, this study aimed to examine the relationship among critical thinking, self-directed learning, and problem-solving in student nurses attending online classes, and to determine whether self-directed learning could mediate the relationship between critical thinking and problem-solving. Design: Cross-sectional, descriptive design. Setting: K University in South Korea. Participants: In total, 138 junior and senior nursing students were enrolled. Methods: The critical thinking disposition scale for nursing students, self-directed learning scale, and problem-solving scale for college students were used to quantify participants' responses. Results: Our results revealed significant positive correlations among critical thinking, self-directed learning, and problem-solving. Furthermore, self-directed learning (beta = 0.78, p < 0.001) had a significant mediating effect on the relationship between critical thinking and problem-solving ability (Z = 5.10, p < 0.001). Conclusion: Developing and implementing appropriate self-directed learning programs are critical for improving problem-solving ability affected by critical thinking among student nurses engaged in online education. | Song, Yeoungsuk; Lee, Yoonmi; Lee, Junghoon | Kyungpook Natl Univ, Coll Nursing, Res Inst Nursing Sci, Daegu, South Korea | Song, Yeoungsuk/MSZ-3096-2025 | 55494171100; 57224358209; 57218996809 | asansong@knu.ac.kr;kwn1357@knu.ac.kr; | NURSE EDUCATION TODAY | NURS EDUC TODAY | 0260-6917 | 1532-2793 | 109 | SCIE;SSCI | EDUCATION, SCIENTIFIC DISCIPLINES;NURSING | 2022 | 3.9 | 7.6 | 7.82 | 2025-06-25 | 38 | 45 | Student nurses; Online education; Critical thinking; Problem-solving; Self-directed learning | NURSING-STUDENTS; ABILITY; ENGAGEMENT; EDUCATION | Critical thinking; Online education; Problem-solving; Self-directed learning; Student nurses | Cross-Sectional Studies; Humans; Learning; Problem Solving; Students, Nursing; Thinking; cross-sectional study; human; learning; nursing student; problem solving; thinking | English | 2022 | 2022-02 | 10.1016/j.nedt.2021.105227 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Reprogramming of T cell-derived small extracellular vesicles using IL2 surface engineering induces potent anti-cancer effects through miRNA delivery | T cell-derived small extracellular vesicles (sEVs) exhibit anti-cancer effects. However, their anti-cancer potential should be reinforced to enhance clinical applicability. Herein, we generated interleukin-2-tethered sEVs (IL2-sEVs) from engineered Jurkat T cells expressing IL2 at the plasma membrane via a flexible linker to induce an autocrine effect. IL2-sEVs increased the anti-cancer ability of CD8(+) T cells without affecting regulatory T (T-reg) cells and down-regulated cellular and exosomal PD-L1 expression in melanoma cells, causing their increased sensitivity to CD8(+) T cell-mediated cytotoxicity. Its effect on CD8(+) T and melanoma cells was mediated by several IL2-sEV-resident microRNAs (miRNAs), whose expressions were upregulated by the autocrine effects of IL2. Among the miRNAs, miR-181a-3p and miR-223-3p notably reduced the PD-L1 protein levels in melanoma cells. Interestingly, miR-181a-3p increased the activity of CD8(+) T cells while suppressing T-reg cell activity. IL2-sEVs inhibited tumour progression in melanoma-bearing immunocompetent mice, but not in immunodeficient mice. The combination of IL2-sEVs and existing anti-cancer drugs significantly improved anti-cancer efficacy by decreasing PD-L1 expression in vivo. Thus, IL2-sEVs are potential cancer immunotherapeutic agents that regulate both immune and cancer cells by reprogramming miRNA levels. | Jung, Dokyung; Shin, Sanghee; Kang, Sung-Min; Jung, Inseong; Ryu, Suyeon; Noh, Soojeong; Choi, Sung-Jin; Jeong, Jongwon; Lee, Beom Yong; Kim, Kwang-Soo; Kim, Christine Seulki; Yoon, Jong Hyuk; Lee, Chan-Hyeong; Bucher, Felicitas; Kim, Yong-Nyun; Im, Sin-Hyeog; Song, Byoung-Joon; Yea, Kyungmoo; Baek, Moon-Chang | Kyungpook Natl Univ, Exosome Convergence Res Ctr ECRC, Sch Med, Dept Mol Med,CMRI, Daegu 41944, South Korea; DGIST, Dept New Biol, Daegu 41944, South Korea; DGIST, New Biol Res Ctr, Daegu, South Korea; Korea Brain Res Inst, Dept Neural Dev & Dis, Daegu, South Korea; Univ Freiburg, Fac Med, Eye Ctr, Med Ctr, Freiburg, Germany; Natl Canc Ctr, Div Translat Sci, 323 Ilsan ro, Goyang Si, Gyeonggi Do, South Korea; Pohang Univ Sci & Technol POSTECH, Dept Life Sci, Gyeongsangbuk Do, South Korea; Yonsei Univ, Inst Convergence Sci, Seoul, South Korea; ImmunoBiome, Pohang, South Korea; NIAAA, Sect Mol Pharmacol & Toxicol, Lab Membrane Biochem & Biophys, Bethesda, MD USA | Kim, Il Young/LLK-4732-2024; Choi, Sung-Jin/ACC-8335-2022; Im, Sin-Hyeog/AAM-9586-2021 | 57207487580; 57202494417; 59499667300; 57223306535; 59787801600; 57223308415; 57435770900; 57211276819; 57211266546; 57223290749; 57209806970; 57212513350; 57189904697; 37057078400; 55917230800; 55583814300; 7402560465; 12769131100; 7006013097 | ykm31@dgist.ac.kr;mcbaek@knu.ac.kr; | JOURNAL OF EXTRACELLULAR VESICLES | J EXTRACELL VESICLES | 2001-3078 | 11 | 12 | SCIE | CELL BIOLOGY | 2022 | 16 | 7.6 | 5.77 | 2025-06-25 | 57 | 56 | cancer; exosomal PD-L1; interleukin-2; PD-L1; small extracellular vesicle; small extracellular vesicle engineering | EXOSOMES; MELANOMA; INTERLEUKIN-2; DACARBAZINE; BIOGENESIS; ACTIVATION; RECEPTORS; IMMUNITY; GROWTH | cancer; exosomal PD-L1; interleukin-2; PD-L1; small extracellular vesicle; small extracellular vesicle engineering | Animals; B7-H1 Antigen; CD8-Positive T-Lymphocytes; Extracellular Vesicles; Interleukin-2; Melanoma; Mice; MicroRNAs; interleukin 2; microRNA; programmed death 1 ligand 1; interleukin 2; programmed death 1 ligand 1; animal experiment; animal model; animal tissue; antineoplastic activity; Article; autocrine signaling; CD8+ T lymphocyte; cellular immunity; confocal microscopy; cytotoxicity assay; exosome; flow cytometry; immunoprecipitation; luminescence; melanoma; melanoma cell; mouse; nonhuman; peripheral blood mononuclear cell; radioimmunoprecipitation; real time reverse transcription polymerase chain reaction; RNA extraction; RNA isolation; tumor growth; animal; genetics; melanoma | English | 2022 | 2022-12 | 10.1002/jev2.12287 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Effect of fiber bending induced matrix shear behavior on machined surface quality in carbon fiber reinforced plastic milling | Fiber bending by the cutting tool is one of the dominant causes of fiber pull-out on machined surfaces during CFRP milling. During the bending, the polymer matrix between the fibers is subjected to shear stress resulting in fiber-matrix debonding. The increase in the debonding length causes an increase in the fiber pull-out length. In milling, not all the new surfaces created by tool-workpiece engagement become the machined surface. However, during this process, the strain energy absorbed by the deformed matrix is released into fiber-matrix debonding along the fibers which can cause fiber pull-out on the machined surface. In this study, shear strain energy of polymer matrix due to fiber bending during milling tool-workpiece engagement was calculated with the geometrical relationship between fibers and a cutting edge. We found that the increase in R-a and R-z of the machined surface had clear tendencies to the increase in the calculated energy. | Kim, Gyuho; Song, Kyeongeun; Jun, Martin Byung-Guk; Jeong, Young Hun; Kim, Tae-Gon; Min, Byung-Kwon | Yonsei Univ, Sch Mech Engn, 50 Yonsei Ro, Seoul 03722, South Korea; Purdue Univ, Sch Mech Engn, 585 Purdue Mall, W Lafayette, IN 47907 USA; Kyungpook Natl Univ, Sch Mech Engn, 80 Daehakro, Daegu 41566, South Korea; Korea Inst Ind Technol, Mfg Syst R&D Grp, 89 Yangdaegiro Gil, Cheonan Si 31056, Chungcheongnam, South Korea | Song, Kyeongeun/MBV-5648-2025; Min, Byung-Kwon/A-9863-2008 | 56822707900; 57199651953; 24587060000; 56501196300; 58261187200; 57205016903 | bkmin@yonsei.ac.kr; | COMPOSITE STRUCTURES | COMPOS STRUCT | 0263-8223 | 1879-1085 | 287 | SCIE | MATERIALS SCIENCE, COMPOSITES;MECHANICS | 2022 | 6.3 | 7.7 | 0.6 | 2025-06-25 | 7 | 8 | Fiber bending; fiber-matrix debonding; Fiber pull-out; Surface roughness | FORMATION MECHANISM; DAMAGE; MACHINABILITY; DELAMINATION; DEFECTS | Fiber bending; Fiber pull-out; fiber-matrix debonding; Surface roughness | Carbon fiber reinforced plastics; Cutting tools; Debonding; Fibers; Shear flow; Shear strain; Shear stress; Strain energy; Surface roughness; Carbon-fibre reinforced plastics; Fiber bending; Fiber pull out; Fiber-matrix debonding; Machined surface; Machined surface quality; Matrix shears; Polymer matrices; Shear behaviour; Tool-workpiece; Milling (machining) | English | 2022 | 2022-05-01 | 10.1016/j.compstruct.2022.115343 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Microbiota modulation and anti-obesity effects of fermented Pyrus ussuriensis Maxim extract against high-fat diet-induced obesity in rats | Pyrus ussuriensis Maxim (Korean pear) has been used for hundreds of years as a traditional herbal medicine due to its strong phytochemical profile and pharmacological efficacy. In this study, we evaluated the anti-obesity potential of Pyrus ussuriensis Maxim extracts (PUE) and investigated the underlying mechanisms using a combination of in vitro, in vivo, and microbiota regulation approaches. In an adipogenesis assay, the fermented (F)PUE and non-fermented (NF)PUE significantly reduced the differentiation of 3T3-L1 preadipocyte in a dose -dependent manner with an IC50 of 85.33 and 96.67 mu g/mL, respectively. In a high-fat diet (HFD)-induced obese rat model (n = 8 animals/group), oral administration of FPUE additionally reduced the total body weight gain significantly. No difference in food intake was observed, however, between the control-chow diet, FPUE, and NFPUE-treated HFD rats. Adipose tissue mass and systemic insulin resistance were markedly reduced in FPUE-treated HFD rats, in a dose-dependent manner. Treatment with FPUE also greatly improved obesity-related biomarkers, including total cholesterol, leptin, active ghrelin, Total GIP, adiponectin, and proinflammatory cytokines. Moreover, FPUE significantly suppressed HFD-induced adipogenic genes expression, while increasing fatty acid oxidation-related genes expression. Additionally, FPUE treatment attenuated the HFD-induced Firmi-cutes proportion within the intestinal microbiota by regulating key metabolic pathways, thus enhancing microbial population diversity (e.g., increasing Bacteroides, Bifidobacterium, Prevotella, Eubacterium, and Clostridium). Together, these results reveal a strong anti-obesity potential of FPUE through adipogenesis, lipid metabolism, weight reduction, and microbiota regulation, raising the possibility of developing FPUE as a novel therapeutic agent to control obesity and obesity-associated metabolic disorders. | Boby, Naila; Abbas, Muhammad Aleem; Lee, Eon-Bee; Im, Zi-Eum; Lee, Seung-Jin; Park, Seung-Chun | Kyungpook Natl Univ, Coll Vet Med, Lab Vet Pharmacokinet & Pharmacodynam, Daegu 41566, South Korea; Anim & Plant Quarantine Agcy, Bacterial Dis Div, 177 Hyeksin 8 ro, Gimcheon 39660, Gyeongsangbuk d, South Korea; Inst Forest Resources Dev, Andong 36605, Gyeongsangbuk d, South Korea; Korea Inst Toxicol, Dev & Reprod Toxicol Res Grp, Daejeon 34114, South Korea; Kyungpook Natl Univ Sch Med, Cardiovasc Res Inst, Gukchabosang ro 680, Daegu 41944, South Korea | Lee, Jung Bok/HHZ-3200-2022; Abbas, Muhammad Aleem/GLT-8362-2022; Lee, Jun Young/CAI-2335-2022; Boby, Naila/GRE-8096-2022; Park, Seung-Chun/AAV-3388-2021 | 57197787296; 57216531374; 57216526135; 57205463137; 58689440900; 7501832396 | nailaboby@knu.ac.kr;syedaleemabbas77@knu.ac.kr;eonbee@knu.ac.kr;zium78@korea.kr;lee.seungjin@kitox.re.kr;parksch@knu.ac.kr; | BIOMEDICINE & PHARMACOTHERAPY | BIOMED PHARMACOTHER | 0753-3322 | 1950-6007 | 154 | SCIE | MEDICINE, RESEARCH & EXPERIMENTAL;PHARMACOLOGY & PHARMACY | 2022 | 7.5 | 7.7 | 1.37 | 2025-06-25 | 10 | 12 | Pyrus ussuriensis Maxim; High-fat diet; Obesity; Gut microbiota | BACILLUS-SUBTILIS; TRANSCRIPTIONAL CONTROL; GUT MICROBIOTA; ADIPOSE-TISSUE; BODY-WEIGHT; PPAR-GAMMA; METABOLISM; DIFFERENTIATION; ADIPOGENESIS; INHIBITION | Gut microbiota; High-fat diet; Obesity; Pyrus ussuriensis Maxim | 3T3-L1 Cells; Adipogenesis; Animals; Anti-Obesity Agents; Diet, High-Fat; Mice; Mice, Inbred C57BL; Microbiota; Obesity; Plant Extracts; Pyrus; Rats; adiponectin; antiobesity agent; arabinitol; beta hydroxyphenyl lactic acid; catechol; erythritol; fenofibrate; gamma glutamyltransferase; Garcinia extract; gastric inhibitory polypeptide; ghrelin; glucose; high density lipoprotein; insulin; interleukin 6; lactic acid; leptin; low density lipoprotein; phenaglycodol; plant extract; Pyrus ussuriensis extract; tetramethyl pyrazine; triacylglycerol; unclassified drug; antiobesity agent; plant extract; 3T3-L1 cell line; adipocyte; adipogenesis; adipose tissue; animal experiment; animal model; antiobesity activity; Article; Bacteroides; Bifidobacterium; body weight; body weight gain; cell differentiation; cell viability; chemical structure; Clostridium; controlled study; cytotoxicity; diet-induced obesity; Eubacterium; fatty acid oxidation; gas chromatography; gene expression; glucose blood level; IC50; in vitro study; in vivo study; insulin resistance; intestine flora; lipid diet; lipid metabolism; lipid storage; liquid chromatography-mass spectrometry; male; mesenteric fat; nonhuman; Prevotella; proadipocyte; Pyrus; Pyrus ussuriensis; rat; real time reverse transcription polymerase chain reaction; regulatory mechanism; RNA isolation; triacylglycerol blood level; adverse event; animal; C57BL mouse; metabolism; microflora; mouse; obesity | English | 2022 | 2022-10 | 10.1016/j.biopha.2022.113629 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | A hybrid machine-learning model for predicting the waste generation rate of building demolition projects | Information on waste generation rate (WGR) is useful for waste management. Recently, several studies have been conducted to predict WGR using artificial intelligence (AI) to the end of realizing smart waste management. Additionally, to improve the performance of machine learning (ML) predictive models, several strategies have also been tested of recent. This study aimed to develop a hybrid ML predictive model to enhance prediction performance for small datasets consisting mainly of categorical variables. Artificial neural network (multi-layer perceptron) (ANN (MLP)) and support vector machine regression (SVMR) algorithms were selected, and cate-gorical principal components analysis (CATPCA) was applied. Accordingly, four predictive models-ANN (MLP), SVMR, CATPCA-ANN (MLP), and CATPCA-SVMR-were developed. The CATPCA-ANN (MLP) model showed some improvements in statistical metrics as compared to the ANN (MLP) model, and the CATPCA-SVMR model showed a far better performance across all statistical metrics than the SVMR model. The best prediction per-formance was found in the CATPCA-SVMR model (R2 = 0.594, R = 0.770), which was thus considered the best model of the four developed. Here, the mean DWGR was 1165.04 kg/m2 for the observed values, and that for the predicted values was 1161.52 kg/m2. Thus, a novel method was proposed for developing a hybrid ML model to enhance prediction performance for small datasets consisting of categorical variables. The results of this study enable the use of ML algorithms, which are disadvantageous with respect to use of categorical variables, by using CATPCA, and we suggest a new AI approach to develop a predictive DWGR model with excellent predictive performance. | Cha, Gi-Wook; Moon, Hyeun Jun; Kim, Young -Chan | Kyungpook Natl Univ, Sch Sci & Technol Accelerat Engn, Daegu 41566, South Korea; Dankook Univ, Dept Architectural Engn, Yongin 16890, South Korea; Dongguk Univ, Div Smart Safety Engn, 123 Dongdae-ro,wise campus, Gyeongju 38066, South Korea | 55754413300; 24559146700; 56463201400 | cgwgnr@gmail.com;honjunmoon@gmail.com;yyoungchani@gmail.com; | JOURNAL OF CLEANER PRODUCTION | J CLEAN PROD | 0959-6526 | 1879-1786 | 375 | SCIE | ENGINEERING, ENVIRONMENTAL;ENVIRONMENTAL SCIENCES;GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY | 2022 | 11.1 | 7.8 | 2.84 | 2025-06-25 | 33 | 45 | Categorical principal components analysis; (CATPCA); Construction and demolition waste (C & DW); Waste management (WM); Hybrid machine -learning model; Small datasets; Categorical variables | MUNICIPAL SOLID-WASTE; MULTIPLE LINEAR-REGRESSION; ARTIFICIAL NEURAL-NETWORKS; SUPPORT VECTOR MACHINE; CONSTRUCTION WASTE; MANAGEMENT; CHINA; CLASSIFICATION; PERFORMANCE; SVM | Categorical principal components analysis (CATPCA); Categorical variables; Construction and demolition waste (C&DW); Hybrid machine-learning model; Small datasets; Waste management (WM) | Demolition; Forecasting; Multilayer neural networks; Network layers; Support vector machines; Waste management; Categorical principal component analyse; Categorical variables; Construction and demolition waste; Hybrid machine learning; Hybrid machine-learning model; Machine learning models; Principal-component analysis; Small data set; Waste management; Principal component analysis | English | 2022 | 2022-11-15 | 10.1016/j.jclepro.2022.134096 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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