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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Diagnostic Value of a Wearable Continuous Electrocardiogram Monitoring Device (AT-Patch) for New-Onset Atrial Fibrillation in High-Risk Patients: Prospective Cohort Study | Background: While conventional electrocardiogram monitoring devices are useful for detecting atrial fibrillation, they have considerable drawbacks, including a short monitoring duration and invasive device implantation. The use of patch-type devices circumvents these drawbacks and has shown comparable diagnostic capability for the early detection of atrial fibrillation. Objective: We aimed to determine whether a patch-type device (AT-Patch) applied to patients with a high risk of new-onset atrial fibrillation defined by the congestive heart failure, hypertension, age >= 75 years, diabetes mellitus, stroke, vascular disease, age 65-74 years, sex scale (CHA(2)DS(2)-VASc) score had increased detection rates. Methods: In this nonrandomized multicenter prospective cohort study, we enrolled 320 adults aged >= 19 years who had never experienced atrial fibrillation and whose CHA(2)DS(2)-VASc score was >= 2. The AT-Patch was attached to each individual for 11 days, and the data were analyzed for arrhythmic events by 2 independent cardiologists. Results: Atrial fibrillation was detected by the AT-Patch in 3.4% (11/320) of patients, as diagnosed by both cardiologists. Interestingly, when participants with or without atrial fibrillation were compared, a previous history of heart failure was significantly more common in the atrial fibrillation group (n=4/11, 36.4% vs n=16/309, 5.2%, respectively; P=.003). When a CHA(2)DS(2)-VASc score >= 4 was combined with previous heart failure, the detection rate was significantly increased to 24.4%. Comparison of the recorded electrocardiogram data revealed that supraventricular and ventricular ectopic rhythms were significantly more frequent in the new-onset atrial fibrillation group compared with nonatrial fibrillation group (3.4% vs 0.4%; P=.001 and 5.2% vs 1.2%; P<.001), respectively. Conclusions: This study detected a moderate number of new-onset atrial fibrillations in high-risk patients using the AT-Patch device. Further studies will aim to investigate the value of early detection of atrial fibrillation, particularly in patients with heart failure as a means of reducing adverse clinical outcomes of atrial fibrillation. | Kwun, Ju-Seung; Lee, Jang Hoon; Park, Bo Eun; Park, Jong Sung; Kim, Hyeon Jeong; Kim, Sun-Hwa; Jeon, Ki-Hyun; Cho, Hyoung-won; Kang, Si-Hyuck; Lee, Wonjae; Youn, Tae-Jin; Chae, In-Ho; Yoon, Chang-Hwan | Seoul Natl Univ, Cardiovasc Ctr, Bundang Hosp, Seongnam Si, South Korea; Kyungpook Natl Univ Hosp, Dept Internal Med, Daegu, South Korea; Sihwa Med Ctr, Dept Internal Med, Siheung Si, South Korea; Seoul Natl Univ, Bundang Hosp, Cardiovasc Ctr, 82,Gumi Ro 173, Seongnam Si 13620, South Korea | ; Youn, Tae-Jin/J-5534-2012; Kang, Si-Hyuck/AAR-9790-2020; Chae, In-Ho/J-5682-2012; Yoon, Changhwan/MXM-0567-2025; Jeon, Ki-Hyun/IZD-4988-2023 | 57220856286; 54581258000; 57201131446; 58363053000; 57204359002; 57203773036; 56253054100; 57222361957; 35740757100; 57209047818; 34772316800; 35274374100; 7202882965 | kunson2@snu.ac.kr; | JOURNAL OF MEDICAL INTERNET RESEARCH | J MED INTERNET RES | 1438-8871 | 25 | SCIE | HEALTH CARE SCIENCES & SERVICES;MEDICAL INFORMATICS | 2023 | 5.8 | 5.5 | 0.38 | 2025-06-25 | 4 | 3 | arrhythmias; atrial fibrillation; wearable electronic device; patch electrocardiogram monitor; electrocardiogram; adult; AT-Patch; heart failure; mobile phone | STROKE PREVENTION; HEART-FAILURE; STRATIFICATION; PREVALENCE | adult; arrhythmias; AT-Patch; atrial fibrillation; electrocardiogram; heart failure; mobile phone; patch electrocardiogram monitor; wearable electronic device | Adult; Atrial Fibrillation; Electrocardiography; Heart Failure; Humans; Prospective Studies; Wearable Electronic Devices; acetylsalicylic acid; angiotensin receptor antagonist; antidiabetic agent; antihypertensive agent; beta adrenergic receptor blocking agent; calcium channel blocking agent; dipeptidyl carboxypeptidase inhibitor; hydroxymethylglutaryl coenzyme A reductase inhibitor; purinergic P2Y receptor antagonist; adult; age; aged; Article; atrial fibrillation; cardiologist; CHA2DS2-VASc score; clinical outcome; cohort analysis; congestive heart failure; diabetes mellitus; diagnostic value; electrocardiogram; female; heart supraventricular arrhythmia; heart ventricle arrhythmia; high risk patient; human; hypertension; incidence; major clinical study; male; medical history; middle aged; multicenter study; new-onset atrial fibrillation; prospective study; pruritus; rash; transient ischemic attack; vascular disease; atrial fibrillation; clinical trial; electrocardiography; heart failure | English | 2023 | 2023-09-18 | 10.2196/45760 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Long-term tactile hypersensitivity after nerve crush injury in mice is characterized by the persistence of intact sensory axons | Supplemental Digital Content is Available in the Text.The escape of sensory axons from Wallerian degeneration is a risk factor for long-term hypersensitivity after crush injury to a peripheral nerve. Traumatic peripheral nerve injuries are at high risk of neuropathic pain for which novel effective therapies are urgently needed. Preclinical models of neuropathic pain typically involve irreversible ligation and/or nerve transection (neurotmesis). However, translation of findings to the clinic has so far been unsuccessful, raising questions on injury model validity and clinically relevance. Traumatic nerve injuries seen in the clinic commonly result in axonotmesis (ie, crush), yet the neuropathic phenotype of "painful" nerve crush injuries remains poorly understood. We report the neuropathology and sensory symptoms of a focal nerve crush injury using custom-modified hemostats resulting in either complete ("full") or incomplete ("partial") axonotmesis in adult mice. Assays of thermal and mechanically evoked pain-like behavior were paralleled by transmission electron microscopy, immunohistochemistry, and anatomical tracing of the peripheral nerve. In both crush models, motor function was equally affected early after injury; by contrast, partial crush of the nerve resulted in the early return of pinprick sensitivity, followed by a transient thermal and chronic tactile hypersensitivity of the affected hind paw, which was not observed after a full crush injury. The partially crushed nerve was characterized by the sparing of small-diameter myelinated axons and intraepidermal nerve fibers, fewer dorsal root ganglia expressing the injury marker activating transcription factor 3, and lower serum levels of neurofilament light chain. By day 30, axons showed signs of reduced myelin thickness. In summary, the escape of small-diameter axons from Wallerian degeneration is likely a determinant of chronic pain pathophysiology distinct from the general response to complete nerve injury. | Kim, Hyoung Woo; Shim, Sang Wook; Zhao, Anna Mae; Roh, Dahee; Han, Hye Min; Middleton, Steven J.; Kim, Wheedong; Chung, Sena; Johnson, Errin; Prentice, John; Tacon, Mike; Koel-Simmelink, Marleen J. A.; Wieske, Luuk; Teunissen, Charlotte E.; Bae, Yong Chul; Bennett, David L. H.; Rinaldi, Simon; Davies, Alexander J.; Oh, Seog Bae | Seoul Natl Univ, Sch Dent, Dept Neurobiol & Physiol, Seoul, South Korea; Seoul Natl Univ, Dent Res Inst, Seoul, South Korea; Seoul Natl Univ, Coll Nat Sci, Dept Brain & Cognit Sci, Seoul, South Korea; Univ Oxford, John Radcliffe Hosp, Nuffield Dept Clin Neurosci, Oxford, England; Kyungpook Natl Univ, Sch Dent, Dept Anat & Neurobiol, Daegu, South Korea; Univ Oxford, Sir William Dunn Sch Pathol, Oxford, England; Univ Oxford, Oxford Inst Radiat Oncol, Old Rd Campus Res Bldg, Oxford, England; Univ Oxford, Dept Phys, Denys Wilkinson Bldg, Oxford, England; Vrije Univ Amsterdam, Dept Lab Med, Neurochem Lab, Amsterdam Neurosci Neurodegenerat,Amsterdam UMC, Amsterdam, Netherlands; Amsterdam UMC, Dept Neurol & Neurophysiol, Acad Med Ctr, Amsterdam Neurosci, Amsterdam, Netherlands; Seoul Natl Univ, Dept Neurobiol & Physiol, Sch Dent, 101 Daehak Ro, Seoul 03080, South Korea; Seoul Natl Univ, Dent Res Inst, 101 Daehak Ro, Seoul 03080, South Korea | ; OH, Seog/AAQ-2478-2020 | 57194786188; 57753570600; 58584879200; 58586426900; 57204187581; 57220541114; 57487995000; 57193000797; 55641542800; 55760411400; 6507155732; 23474135000; 25026468500; 57210241893; 56377838800; 35560851800; 25226089500; 35315427900; 7404103749 | hyoungwookim1@snu.ac.kr;akfn3639@gmail.com;annamae.zhao@oriel.ox.ac.uk;raeeroh@gmail.com;qkqkqh1122@nate.com;steven.middleton@ndcn.ox.ac.uk;cruelbait@gmail.com;s_e_na@snu.ac.kr;errin.johnson@path.ox.ac.uk;john.prentice@oncology.ox.ac.uk;mike.tacon@physics.ox.ac.uk;mja.koel-simmelink@amsterdamumc.nl;l.wieske@amsterdamumc.nl;c.teunissen@amsterdamumc.nl;ycbae@knu.ac.kr;david.bennett@ndcn.ox.ac.uk;simon.rinaldi@ndcn.ox.ac.uk;alexander.davies@ndcn.ox.ac.uk;odolbae@snu.ac.kr; | PAIN | PAIN | 0304-3959 | 1872-6623 | 164 | 10 | SCIE | ANESTHESIOLOGY;CLINICAL NEUROLOGY;NEUROSCIENCES | 2023 | 5.9 | 5.5 | 0.64 | 2025-06-25 | 3 | 3 | Axonotmesis; Chronic pain; Mechanical allodynia; Peripheral nerve injury; Neuropathic pain; Partial crush; Preclinical pain model; Wallerian degeneration | NEUROPATHIC PAIN; SCIATIC-NERVE; FUNCTIONAL RECOVERY; WALLERIAN DEGENERATION; CHRONIC CONSTRICTION; POSTSURGICAL PAIN; MYELIN SHEATHS; DORSAL-HORN; SPINAL-CORD; RAT | Axonotmesis; Chronic pain; Mechanical allodynia; Neuropathic pain; Partial crush; Peripheral nerve injury; Preclinical pain model; Wallerian degeneration | Animals; Axons; Crush Injuries; Mice; Nerve Crush; Nerve Regeneration; Neuralgia; Peripheral Nerve Injuries; Rats; Rats, Sprague-Dawley; Sciatic Nerve; activating transcription factor 3; carprofen; isoflurane; myelin; neurofilament protein; oxygen; axon; adult; animal cell; animal experiment; animal model; animal tissue; Article; axon; axonotmesis; controlled study; denervation; experimental neuropathic pain; female; hind paw; immunohistochemistry; innervation; light chain; male; mechanical hyperalgesia; medical research; motor performance; mouse; myelinated nerve; nerve crush; nerve fiber; nerve fiber degeneration; nerve regeneration; neuropathology; nonhuman; peripheral nerve; peripheral nerve injury; pinprick test; prevalence; sensory nerve; sensory nerve cell; spinal ganglion; tactile hypersensitivity; thermal hyperalgesia; thickness; transmission electron microscopy; Wallerian degeneration; animal; crush trauma; nerve crush; neuralgia; pathology; peripheral nerve injury; physiology; rat; sciatic nerve; Sprague Dawley rat | English | 2023 | 2023-10 | 10.1097/j.pain.0000000000002937 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Supervised Relation Extraction Between Suicide-Related Entities and Drugs: Development and Usability Study of an Annotated PubMed Corpus | Background: Drug-induced suicide has been debated as a crucial issue in both clinical and public health research. Published research articles contain valuable data on the drugs associated with suicidal adverse events. An automated process that extracts such information and rapidly detects drugs related to suicide risk is essential but has not been well established. Moreover, few data sets are available for training and validating classification models on drug-induced suicide. Objective: This study aimed to build a corpus of drug-suicide relations containing annotated entities for drugs, suicidal adverse events, and their relations. To confirm the effectiveness of the drug-suicide relation corpus, we evaluated the performance of a relation classification model using the corpus in conjunction with various embeddings. Methods: We collected the abstracts and titles of research articles associated with drugs and suicide from PubMed and manually annotated them along with their relations at the sentence level (adverse drug events, treatment, suicide means, or miscellaneous). To reduce the manual annotation effort, we preliminarily selected sentences with a pretrained zero-shot classifier or sentences containing only drug and suicide keywords. We trained a relation classification model using various Bidirectional Encoder Representations from Transformer embeddings with the proposed corpus. We then compared the performances of the model with different Bidirectional Encoder Representations from Transformer-based embeddings and selected the most suitable embedding for our corpus. Results: Our corpus comprised 11,894 sentences extracted from the titles and abstracts of the PubMed research articles. Each sentence was annotated with drug and suicide entities and the relationship between these 2 entities (adverse drug events, treatment, means, and miscellaneous). All of the tested relation classification models that were fine-tuned on the corpus accurately detected sentences of suicidal adverse events regardless of their pretrained type and data set properties. Conclusions: To our knowledge, this is the first and most extensive corpus of drug-suicide relations. | Karapetian, Karina; Jeon, Soo Min; Kwon, Jin-Won; Suh, Young-Kyoon | Kyungpook Natl Univ, Sch Comp Sci & Engn, Daegu, South Korea; Jeju Natl Univ, Coll Pharm, Jeju, South Korea; Kyungpook Natl Univ, Coll Pharm, Commun Based Intelligent Novel Drug Discovery Educ, Daegu, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Daegu, South Korea; Kyungpook Natl Univ, Sch Comp Sci & Engn, Rm 520, IT-5, 80 Daehak-ro, Daegu 41566, South Korea | 58140678700; 57206855645; 16202951700; 55443739900 | yksuh@knu.ac.kr; | JOURNAL OF MEDICAL INTERNET RESEARCH | J MED INTERNET RES | 1438-8871 | 25 | SCIE | HEALTH CARE SCIENCES & SERVICES;MEDICAL INFORMATICS | 2023 | 5.8 | 5.5 | 0.51 | 2025-06-25 | 2 | 4 | suicide; adverse drug events; information extraction; relation classification; bidirectional encoder representations from transformers; pharmacovigilance; natural language processing; PubMed; corpus; language model | AGREEMENT; CLASSIFICATION; RISK | adverse drug events; bidirectional encoder representations from transformers; corpus; information extraction; language model; natural language processing; pharmacovigilance; PubMed; relation classification; suicide | Drug-Related Side Effects and Adverse Reactions; Humans; Language; Natural Language Processing; PubMed; Suicide; amitriptyline; analgesic agent; antidepressant agent; barbituric acid derivative; buprenorphine; caffeine; clozapine; cocaine; colchicine; diazepam; drug; esketamine; fluoxetine; insulin; isotretinoin; ketamine; lithium; metformin; milnacipran; nicotine; olanzapine; paracetamol; paroxetine; rimonabant; varenicline; venlafaxine; zolpidem; Article; classifier; controlled study; data extraction; disease classification; drug induced disease; human; Medline; natural language processing; suicide; usability; adverse drug reaction; language; suicide | English | 2023 | 2023-03-08 | 10.2196/41100 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Characterization of a new CCCTC-binding factor binding site as a dual regulator of Epstein-Barr virus latent infection | Author summaryA CCCTC-binding factor binding site (S13 locus) on the BamHI A right transcript miRNA promoter was identified by Chromatin immunoprecipitation followed by sequencing and MST assays. Next, we investigated the functional roles of the S13 locus using reverse genetics followed by 4C-Seq and 3C-PCR assays. We found that in the presence of the 11.8-kb EcoRI C fragment, the S13 locus is associated with overall EBV genomic loci including 3-kb (S1) and 167-kb (S16). Reverse genetic studies demonstrated that the S13 locus plays an inhibitory role in EBV BART miRNA expression and lytic reactivation in the presence of the EcoRI C fragment. Thus, the S13 locus is suggested to form a cluster of DNA loops with the OriP (S1) and LMP1/2 (S16) loci to coordinate the EBV life cycle. Distinct viral gene expression characterizes Epstein-Barr virus (EBV) infection in EBV-producing marmoset B-cell (B95-8) and EBV-associated gastric carcinoma (SNU719) cell lines. CCCTC-binding factor (CTCF) is a structural chromatin factor that coordinates chromatin interactions in the EBV genome. Chromatin immunoprecipitation followed by sequencing against CTCF revealed 16 CTCF binding sites in the B95-8 and SNU719 EBV genomes. The biological function of one CTCF binding site (S13 locus) located on the BamHI A right transcript (BART) miRNA promoter was elucidated experimentally. Microscale thermophoresis assay showed that CTCF binds more readily to the stable form than the mutant form of the S13 locus. EBV BART miRNA clusters encode 22 miRNAs, whose roles are implicated in EBV-related cancer pathogenesis. The B95-8 EBV genome lacks a 11.8-kb EcoRI C fragment, whereas the SNU719 EBV genome is full-length. ChIP-PCR assay revealed that CTCF, RNA polymerase II, H3K4me3 histone, and H3K9me3 histone were more enriched at S13 and S16 (167-kb) loci in B95-8 than in the SNU719 EBV genome. 4C-Seq and 3C-PCR assays using B95-8 and SNU719 cells showed that the S13 locus was associated with overall EBV genomic loci including 3-kb and 167-kb region in both EBV genomes. We generated mutations in the S13 locus in bacmids with or without the 11.8-kb BART transcript unit (BART(+/-)). The S13 mutation upregulated BART miRNA expression, weakened EBV latency, and reduced EBV infectivity in the presence of EcoRI C fragment. Another 3C-PCR assay using four types of BART(+/-)center dot S13(wild-type(Wt)/mutant(Mt)) HEK293-EBV cells revealed that the S13 mutation decreased DNA associations between the 167-kb region and 3-kb in the EBV genome. Based on these results, CTCF bound to the S13 locus along with the 11.8-kb EcoRI C fragment is suggested to form an EBV 3-dimensional DNA loop for coordinated EBV BART miRNA expression and infectivity. | Lee, Sun Hee; Kim, Kyoung-Dong; Cho, Miyeon; Huh, Sora; An, Seong Ho; Seo, Donghyun; Kang, Kyuhyun; Lee, Minhee; Tanizawa, Hideki; Jung, Inuk; Cho, Hyosun; Kang, Hyojeung | Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, Vessel Organ Interact Res Ctr, Daegu, South Korea; Chung Ang Univ, Dept Syst Biotechnol, Anseong, South Korea; Univ Oregon, Inst Mol Biol, Eugene, OR USA; Kyungpook Natl Univ, Dept Comp Sci & Engn, Daegu, South Korea; Duksung Womens Univ, Coll Pharm, Duksung Innovat Drug Ctr, Seoul, South Korea | Tanizawa, Hideki/Z-1107-2019 | 58607352900; 56948176000; 57190213901; 57195521220; 58078343200; 58079865000; 58079354700; 58078594800; 55381345900; 56067575500; 55572361200; 8979751700 | hyosun1102@duksung.ac.kr;hkang72@knu.ac.kr; | PLOS PATHOGENS | PLOS PATHOG | 1553-7366 | 1553-7374 | 19 | 1 | SCIE | MICROBIOLOGY;PARASITOLOGY;VIROLOGY | 2023 | 5.5 | 5.6 | 1.01 | 2025-06-25 | 6 | 6 | C-MYC; GASTRIC-CARCINOMA; CTCF; GENE; TRANSCRIPTION; EXPRESSION; DNA; INSULATORS; MICRORNAS; SEQUENCE | Binding Sites; CCCTC-Binding Factor; Chromatin; Epstein-Barr Virus Infections; HEK293 Cells; Herpesvirus 4, Human; Histones; Humans; Latent Infection; MicroRNAs; carboxyfluorescein; estradiol; genomic DNA; histone; hygromycin B; kanamycin; microRNA; RNA polymerase II; transcription factor CTCF; microRNA; transcription factor CTCF; Article; assay; binding site; bioinformatics; cell lysate; DNA damage; DNA extraction; DNA sequence; Epstein Barr virus; Epstein Barr virus infection; gene amplification; gene expression; genetic transcription; genetic transfection; HEK293 cell line; human; human cell; immunoblotting; immunoprecipitation; in situ hybridization; latent virus infection; malignant neoplasm; Microscale thermophoresis assay; polymerase chain reaction; protein expression; protein function; protein purification; real time polymerase chain reaction; RNA sequence; Sanger sequencing; SNU-719 cell line; Southern blotting; stomach carcinoma; Western blotting; wild type; binding site; chromatin; genetics; infection | English | 2023 | 2023-01 | 10.1371/journal.ppat.1011078 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Correction | Comparison of 2-year mortality according to obesity in stabilized patients with type 2 diabetes mellitus after acute myocardial infarction: results from the DIAMOND prospective cohort registry (vol 14, 141, 2015) | Won, Ki-Bum; Hur, Seung-Ho; Cho, Yun-Kyeong; Yoon, Hyuck-Jun; Nam, Chang-Wook; Kim, Kwon-Bae; Bae, Jang-Ho; Choi, Dong-Ju; Ahn, Young-Keun; Park, Jong-Seon; Kim, Hyo-Soo; Choi, Rak-Kyeong; Choi, Donghoon; Kim, Joon-Hong; Han, Kyoo-Rok; Park, Hun-Sik; Choi, So-Yeon; Yoon, Jung-Han; Kwon, Hyeon-Cheol; Rha, Seung-Woon; Hwang, Kyung-Kuk; Lim, Do-Sun; Jung, Kyung-Tae; Oh, Seok-Kyu; Lee, Jae-Hwan; Shin, Eun-Seok; Kim, Kee-Sik | Keimyung Univ, Div Cardiol, Dongsan Med Ctr, Daegu, South Korea; Konyang Univ Hosp, Div Cardiol, Daejeon, South Korea; Seoul Natl Univ Bundang Hosp, Div Cardiol, Seongnam, South Korea; Chonnam Natl Univ Hosp, Div Cardiol, Gwangju, South Korea; Yeungnam Univ Hosp, Div Cardiol, Daegu, South Korea; Seoul Natl Univ Hosp, Div Cardiol, 28 Yeongeon Dong,Chongno Gu, Seoul 110744, South Korea; Sejong Gen Hosp, Div Cardiol, Bucheon, South Korea; Yonsei Univ Severance Hosp, Div Cardiol, Seoul, South Korea; Pusan Natl Univ Yangsan Hosp, Div Cardiol, Yangsan, South Korea; Hallym Univ Kangdong Sacred Heart Hosp, Div Cardiol, Seoul, South Korea; Kyungpook Natl Univ Hosp, Div Cardiol, Daegu, South Korea; Ajou Univ Hosp, Div Cardiol, Suwon, South Korea; Wonju Severance Christian Hosp, Div Cardiol, Wonju, South Korea; Samsung Med Ctr, Div Cardiol, Seoul, South Korea; Korea Univ, Div Cardiol, Guro Hosp, Seoul, South Korea; Chungbuk Natl Univ Hosp, Div Cardiol, Cheongju, South Korea; Korea Univ, Div Cardiol, Anam Hosp, Seoul, South Korea; Eulji Univ Hosp, Div Cardiol, Daejeon, South Korea; Wonkwang Univ Hosp, Div Cardiol, Iksan, South Korea; Chungnam Natl Univ Hosp, Div Cardiol, Daejeon, South Korea; Ulsan Univ Hosp, Div Cardiol, Ulsan, South Korea; Daegu Catholic Univ, Div Cardiol, Med Ctr, Daegu, South Korea | Park, Hang-soo/AEH-1640-2022; Rha, Seung-Woon/AGE-5810-2022; Kim, Seonghwan/AAZ-1679-2021; Kim, Jung Kyu/C-3271-2012; Jeong, Young-Hoon/F-3476-2015; Choi, Dong-Ju/J-5686-2012; Yoon, HJ/IYJ-7484-2023; Lee, Yoon/ABA-8808-2020; Kim, Hyo/J-2753-2012; Choi, So/AAV-1947-2020 | 55257125600; 34570274500; 16836104200; 36175243200; 34571810200; 8319343800; 7201385490; 35274349200; 56937721300; 15763054600; 33567809200; 55238485900; 23110215500; 58412622000; 7402963418; 57198844106; 7408121945; 35760728900; 58415677100; 8569030400; 7402426370; 7401816184; 55277083200; 24734336000; 36066387900; 35273651500; 8400293100 | hyosoo@snu.ac.kr; | CARDIOVASCULAR DIABETOLOGY | CARDIOVASC DIABETOL | 1475-2840 | 22 | 1 | SCIE | CARDIAC & CARDIOVASCULAR SYSTEMS;ENDOCRINOLOGY & METABOLISM | 2023 | 8.5 | 5.6 | 3.39 | 2025-06-25 | 0 | 1 | erratum | English | 2023 | 2023-06-29 | 10.1186/s12933-023-01889-2 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||||
| ○ | ○ | Article | Discovery and rational engineering of PET hydrolase with both mesophilic and thermophilic PET hydrolase properties | Extensive research efforts have been directed towards the development of PET hydrolases with improved activity, but template enzymes used are limited. Here, the authors report a PET hydrolase from Cryptosporangium aurantiacum (CaPETase) that exhibits high thermostability and PET degradation activity at ambient temperatures and determine its crystal structure. Excessive polyethylene terephthalate (PET) waste causes a variety of problems. Extensive research focused on the development of superior PET hydrolases for PET biorecycling has been conducted. However, template enzymes employed in enzyme engineering mainly focused on IsPETase and leaf-branch compost cutinase, which exhibit mesophilic and thermophilic hydrolytic properties, respectively. Herein, we report a PET hydrolase from Cryptosporangium aurantiacum (CaPETase) that exhibits high thermostability and remarkable PET degradation activity at ambient temperatures. We uncover the crystal structure of CaPETase, which displays a distinct backbone conformation at the active site and residues forming the substrate binding cleft, compared with other PET hydrolases. We further develop a CaPETase(M9) variant that exhibits robust thermostability with a T-m of 83.2 & DEG;C and 41.7-fold enhanced PET hydrolytic activity at 60 & DEG;C compared with CaPETase(WT). CaPETase(M9) almost completely decompose both transparent and colored post-consumer PET powder at 55 & DEG;C within half a day in a pH-stat bioreactor. | Hong, Hwaseok; Ki, Dongwoo; Seo, Hogyun; Park, Jiyoung; Jang, Jaewon; Kim, Kyung-Jin | Kyungpook Natl Univ, KNU Inst Microorganisms, Sch Life Sci, FOUR KNU Creat Biores Grp BK21, Daegu 41566, South Korea; CJ CheilJedang Co, Inst Biotechnol, Suwon 16495, Gyeonggi, South Korea; Zyen Co, Daegu 41566, South Korea | Park, Jiyoung/MVY-3895-2025; Kim, Kyung-Jin/MVY-3405-2025 | 57208592877; 57219308133; 57189697998; 56188468900; 58509174800; 55510867400 | kkim@knu.ac.kr; | NATURE COMMUNICATIONS | NAT COMMUN | 2041-1723 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 14.7 | 5.6 | 5.66 | 2025-06-25 | 52 | 55 | PLASTICS; CUTINASE; DEGRADATION; SAKAIENSIS; FEATURES | Actinomycetales; Enzyme Stability; Hydrolases; Hydrolysis; Polyethylene Terephthalates; hydrolase; polyethylene terephthalate; hydrolase; polyethylene terephthalate; ambient air; bioreactor; compost; crystal structure; degradation; enzyme activity; substrate; Article; binding site; calcium binding; comparative study; controlled study; crystal structure; depolymerization; environmental temperature; enzyme activity; enzyme engineering; human; hydrogen bond; maximum likelihood method; melting temperature; phylogeny; point mutation; protein conformation; protein expression; sequence homology; surface charge; thermostability; Actinomycetales; chemistry; enzyme stability; hydrolysis; metabolism | English | 2023 | 2023-07-28 | 10.1038/s41467-023-40233-w | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Enhanced Ca²⁺-channeling complex formation at the ER-mitochondria interface underlies the pathogenesis of alcoholassociated liver disease | Ca2+ overload-induced mitochondrial dysfunction is considered as a major contributing factor in the pathogenesis of alcohol-associated liver disease (ALD). However, the initiating factors that drive mitochondrial Ca2+ accumulation in ALD remain elusive. Here, we demonstrate that an aberrant increase in hepatic GRP75-mediated mitochondria-associated ER membrane (MAM) Ca(2+)channeling (MCC) complex formation promotes mitochondrial dysfunction in vitro and in male mouse model of ALD. Unbiased transcriptomic analysis reveals PDK4 as a prominently inducible MAM kinase in ALD. Analysis of human ALD cohorts further corroborate these findings. Additional mass spectrometry analysis unveils GRP75 as a downstream phosphorylation target of PDK4. Conversely, non-phosphorylatable GRP75 mutation or genetic ablation of PDK4 prevents alcohol-induced MCC complex formation and subsequent mitochondrial Ca2+ accumulation and dysfunction. Finally, ectopic induction ofMAM formation reverses the protective effect of PDK4 deficiency in alcohol-induced liver injury. Together, our study defines a mediatory role of PDK4 in promoting mitochondrial dysfunction in ALD. | Thoudam, Themis; Chanda, Dipanjan; Lee, Jung Yi; Jung, Min-Kyo; Sinam, Ibotombi Singh; Kim, Byung-Gyu; Park, Bo-Yoon; Kwon, Woong Hee; Kim, Hyo-Jeong; Kim, Myeongjin; Lim, Chae Won; Lee, Hoyul; Huh, Yang Hoon; Miller, Caroline A.; Saxena, Romil; Skill, Nicholas J.; Huda, Nazmul; Kusumanchi, Praveen; Ma, Jing; Yang, Zhihong; Kim, Min-Ji; Mun, Ji Young; Harris, Robert A.; Jeon, Jae-Han; Liangpunsakul, Suthat; Lee, In-Kyu | Kyungpook Natl Univ, Res Inst Aging & Metab, Daegu, South Korea; Kyungpook Natl Univ Hosp, Leading Edge Res Ctr Drug Discovery & Dev Diabet, Daegu, South Korea; Korea Brain Res Inst, Neural Circuit Res Grp, Daegu, South Korea; Kyungpook Natl Univ Hosp, Biomed Res Inst, Daegu, South Korea; Inst Basic Sci IBS, Ctr Genom Integr, Ulsan, South Korea; Korea Basic Sci Inst, Electron Microscopy Res Ctr, Ochang, Chungbuk, South Korea; Daegu Catholic Univ, Dept Med, Daegu, South Korea; Indiana Univ Sch Med, Electron Microscopy Core, Indianapolis, IN USA; Indiana Univ Sch Med, Dept Pathol & Lab Med, Indianapolis, IN USA; Emory Univ, Dept Pathol & Lab Med, Sch Med, Atlanta, GA USA; Louisiana State Univ, Dept Surg, Hlth Sci Ctr, New Orleans, LA USA; Indiana Univ Sch Med, Dept Med, Div Gastroenterol & Hepatol, Indianapolis, IN 46202 USA; Kyungpook Natl Univ, Dept Internal Med, Chilgok Hosp, Daegu, South Korea; Indiana Univ Sch Med, Dept Biochem & Mol Biol, Indianapolis, IN 46202 USA; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Richard L Roudebush VA Med Ctr, Indianapolis, IN 46202 USA; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea | Yang, Zhihong/L-5024-2019; Kim, Min-Ji/Z-5205-2019; Mun, Jiyoung/IUN-3520-2023; Chanda, Dipanjan/AAU-3996-2021; thoudam, themis/ACM-3919-2022; Kim, Sun Jung/AAM-7334-2020; Lee, In-Kyu/AAR-6374-2021 | 57192905626; 16416525900; 57195563161; 55701234000; 57846985600; 55797167500; 57191358558; 57204167945; 57261045600; 58158274200; 58158274300; 58017533900; 7102963459; 58158457000; 7202190528; 6603647516; 36817617700; 24831864400; 57201898640; 55716657600; 57206189095; 8654053900; 58710709100; 36910340400; 6602240165; 36071537600 | sliangpu@iu.edu;leei@knu.ac.kr; | NATURE COMMUNICATIONS | NAT COMMUN | 2041-1723 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 14.7 | 5.6 | 3.63 | 2025-06-25 | 31 | 34 | ENDOPLASMIC-RETICULUM; ALCOHOL-CONSUMPTION; INDUCED HYPOTHERMIA; FATTY LIVER; ETHANOL; ROS; SENSITIVITY; EXPRESSION; PROTEINS; CONTACT | Animals; Endoplasmic Reticulum; Humans; Liver Diseases; Male; Mice; Mitochondria; alcohol; calcium channel; calcium ion; glucose regulated protein; glucose regulated protein 75; pyruvate dehydrogenase kinase 4; unclassified drug; ablation; accumulation; disease; mass spectrometry; mitochondrial DNA; mutation; pathogenicity; alcohol liver disease; animal cell; animal experiment; animal model; animal tissue; Article; cohort analysis; complex formation; controlled study; disorders of mitochondrial functions; endoplasmic reticulum membrane; gene mutation; human; human tissue; in vitro study; male; mass spectrometry; mitochondrion; molecular pathology; mouse; nonhuman; protein expression; protein phosphorylation; transcriptomics; animal; endoplasmic reticulum; liver disease; metabolism; mitochondrion | English | 2023 | 2023-03-27 | 10.1038/s41467-023-37214-4 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | ERK2-topoisomerase II regulatory axis is important for gene activation in immediate early genes | The function of the mitogen-activated protein kinase signaling pathway is required for the activation of immediate early genes (IEGs), including EGR1 and FOS, for cell growth and proliferation. Recent studies have identified topoisomerase II (TOP2) as one of the important regulators of the transcriptional activation of IEGs. However, the mechanism underlying transcriptional regulation involving TOP2 in IEG activation has remained unknown. Here, we demonstrate that ERK2, but not ERK1, is important for IEG transcriptional activation and report a critical ELK1 binding sequence for ERK2 function at the EGR1 gene. Our data indicate that both ERK1 and ERK2 extensively phosphorylate the C-terminal domain of TOP2B at mutual and distinctive residues. Although both ERK1 and ERK2 enhance the catalytic rate of TOP2B required to relax positive DNA supercoiling, ERK2 delays TOP2B catalysis of negative DNA supercoiling. In addition, ERK1 may relax DNA supercoiling by itself. ERK2 catalytic inhibition or knock-down interferes with transcription and deregulates TOP2B in IEGs. Furthermore, we present the first cryo-EM structure of the human cell-purified TOP2B and etoposide together with the EGR1 transcriptional start site (-30 to +20) that has the strongest affinity to TOP2B within -423 to +332. The structure shows TOP2B-mediated breakage and dramatic bending of the DNA. Transcription is activated by etoposide, while it is inhibited by ICRF193 at EGR1 and FOS, suggesting that TOP2B-mediated DNA break to favor transcriptional activation. Taken together, this study suggests that activated ERK2 phosphorylates TOP2B to regulate TOP2-DNA interactions and favor transcriptional activation in IEGs. We propose that TOP2B association, catalysis, and dissociation on its substrate DNA are important processes for regulating transcription and that ERK2-mediated TOP2B phosphorylation may be key for the catalysis and dissociation steps. Topoisomerase II (TOP2) has been identified as one of the regulators for the transcriptional activation of immediate early genes IEGs. Here the authors report that ERK1 and ERK2 oppositely regulate transcription and ERK2 regulates TOP2B-DNA interaction and catalysis to favor IEG transcription. | Bunch, Heeyoun; Kim, Deukyeong; Naganuma, Masahiro; Nakagawa, Reiko; Cong, Anh; Jeong, Jaehyeon; Ehara, Haruhiko; Vu, Hongha; Chang, Jeong Ho; Schellenberg, Matthew J.; Sekine, Shun-ichi | Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea; Kyungpook Natl Univ, Coll Agr & Life Sci, Sch Appl Biosci, Daegu 41566, South Korea; RIKEN Ctr Biosyst Dynam Res, Lab Transcript Struct Biol, 1-7-22 Suehiro Cho, Tsurumi Ku, Yokohama 2300045, Japan; RIKEN BDR Lab Phyloinformat, Kobe, Hyogo 6500047, Japan; Mayo Clin, Dept Biochem & Mol Biol, Rochester, MN 55905 USA; Kyungpook Natl Univ, Dept Biol Educ, Daegu 41566, South Korea; Korea Adv Inst Sci & Technol KAIST, Dept Biol Sci, Daejeon 34141, South Korea | Nakagawa, Reiko/C-4214-2017; Sekine, Shun-ichi/N-5450-2015; Bunch, Heeyoun/JAX-3215-2023; Ehara, Haruhiko/C-3643-2017 | 56336812200; 57223415453; 35725983100; 36944193500; 57497568100; 57218602696; 55202255200; 57222482871; 57203598905; 12142213300; 7101752462 | heeyounbunch@gmail.com; | NATURE COMMUNICATIONS | NAT COMMUN | 2041-1723 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 14.7 | 5.6 | 0.64 | 2025-06-25 | 5 | 6 | RNA-POLYMERASE-II; DNA TOPOISOMERASE-II; TRANSCRIPTIONAL ACTIVATION; ERK PHOSPHORYLATION; RECRUITMENT; ELONGATION; ALPHA; ROLES; REPLICATION; PATHWAYS | DNA; DNA Topoisomerases, Type II; Etoposide; Genes, Immediate-Early; Humans; Mitogen-Activated Protein Kinase 1; Phosphorylation; Transcriptional Activation; 2,3 bis(3,5 dioxo 1 piperazinyl)butane; curved DNA; DNA topoisomerase (ATP hydrolysing); etoposide; mitogen activated protein kinase 1; mitogen activated protein kinase 3; protein fos; transcription factor Elk 1; DNA; DNA topoisomerase (ATP hydrolysing); mitogen activated protein kinase 1; catalysis; DNA; gene expression; inhibition; signaling; substrate; Article; binding affinity; carboxy terminal sequence; catalysis; controlled study; cryoelectron microscopy; DNA strand breakage; DNA supercoiling; gene activation; immediate early gene; nucleotide sequence; protein binding; protein phosphorylation; protein structure; transcription initiation; transcription regulation; genetics; human; metabolism; phosphorylation; transcription initiation | English | 2023 | 2023-12-14 | 10.1038/s41467-023-44089-y | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Gapless superconductivity in Nb thin films probed by terahertz spectroscopy | Time-reversal symmetry breaking by an external magnetic field can lead to a novel quantum state called the gapless superconducting state. Here, the authors use magneto-terahertz spectroscopy to study the gapless superconductivity of thin niobium films. Time reversal symmetry (TRS) breaking often generates exotic quantum phases in condensed matter. In superconductors, TRS breaking by an external magnetic field not only suppresses superconductivity but also leads to a novel quantum state called the gapless superconducting state. Here we show that magneto-terahertz spectroscopy provides us with a rare opportunity to access and explore the gapless superconducting state of Nb thin films. We present the complete functional form of the superconducting order parameter for an arbitrary magnetic field, for which a fully self-consistent theory is, surprisingly, yet unavailable. We observe a Lifshitz topological phase transition with a vanishing quasiparticle gap everywhere on the Fermi surface, whereas the superconducting order parameter smoothly crosses over from the gapped to the gapless regime. Our observation of the magnetic pair-breaking effects in Nb challenges traditional perturbative theories and opens a pathway to further exploring and manipulating the exotic state of gapless superconductivity. | Lee, Ji Eun; Choi, Joonyoung; Jung, Taek Sun; Kim, Jong Hyuk; Choi, Young Jai; Sim, Kyung Ik; Jo, Younjung; Kim, Jae Hoon | Yonsei Univ, Dept Phys, Seoul, South Korea; Kyungpook Natl Univ, Dept Phys, Daegu, South Korea; Inst Basic Sci, Ctr Integrated Nanostruct Phys, Suwon, South Korea; Sungkyunkwan Univ, Suwon, South Korea | 57216486402; 57199099536; 57210449302; 57193568510; 26535632200; 55249412800; 13502586500; 55970980000 | simki323@gmail.com;jophy@knu.ac.kr;super@yonsei.ac.kr; | NATURE COMMUNICATIONS | NAT COMMUN | 2041-1723 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 14.7 | 5.6 | 1.6 | 2025-06-25 | 15 | 15 | DENSITY-OF-STATES; FAR-INFRARED ABSORPTION; MEAN-FREE-PATH; MAGNETIC-FIELD; ENERGY-GAP; CONDUCTIVITY; TRANSMISSION; BEHAVIOR; ALLOYS | niobium; equation of state; magnetic field; phase transition; spectroscopy; superconductivity; Article; chemical analysis; conductance; geometry; phase transition; quantum chemistry; self concept; superconductivity; terahertz spectroscopy | English | 2023 | 2023-05-12 | 10.1038/s41467-023-38422-8 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population | Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci. Transcriptome-wide association analyses together with colocalization studies using a Taiwanese lung expression quantitative trait loci dataset (n=115) identified novel candidate genes, including FADS1 at 11q12 and ELF5 at 11p13. In a multi-ancestry meta-analysis of East Asian and European studies, four loci were identified at 2p11, 4q32, 16q23, and 18q12. At the same time, most of our findings in East Asian populations showed no evidence of association in European populations. In our studies drawn from East Asian populations, a polygenic risk score based on the 25 loci had a stronger association in never-smokers vs. individuals with a history of smoking (P-interaction=0.0058). These findings provide new insights into the etiology of lung adenocarcinoma in individuals from East Asian populations, which could be important in developing translational applications. | Shi, Jianxin; Shiraishi, Kouya; Choi, Jiyeon; Matsuo, Keitaro; Chen, Tzu-Yu; Dai, Juncheng; Hung, Rayjean J.; Chen, Kexin; Shu, Xiao-Ou; Kim, Young Tae; Landi, Maria Teresa; Lin, Dongxin; Zheng, Wei; Yin, Zhihua; Zhou, Baosen; Song, Bao; Wang, Jiucun; Seow, Wei Jie; Song, Lei; Chang, I-Shou; Hu, Wei; Chien, Li-Hsin; Cai, Qiuyin; Hong, Yun-Chul; Kim, Hee Nam; Wu, Yi-Long; Wong, Maria Pik; Richardson, Brian Douglas; Funderburk, Karen M.; Li, Shilan; Zhang, Tongwu; Breeze, Charles; Wang, Zhaoming; Blechter, Batel; Bassig, Bryan A.; Kim, Jin Hee; Albanes, Demetrius; Wong, Jason Y. Y.; Shin, Min-Ho; Chung, Lap Ping; Yang, Yang; An, She-Juan; Zheng, Hong; Yatabe, Yasushi; Zhang, Xu-Chao; Kim, Young-Chul; Caporaso, Neil E.; Chang, Jiang; Ho, James Chung Man; Kubo, Michiaki; Daigo, Yataro; Song, Minsun; Momozawa, Yukihide; Kamatani, Yoichiro; Kobayashi, Masashi; Okubo, Kenichi; Honda, Takayuki; Hosgood, Dean H.; Kunitoh, Hideo; Patel, Harsh; Watanabe, Shun-ichi; Miyagi, Yohei; Nakayama, Haruhiko; Matsumoto, Shingo; Horinouchi, Hidehito; Tsuboi, Masahiro; Hamamoto, Ryuji; Goto, Koichi; Ohe, Yuichiro; Takahashi, Atsushi; Goto, Akiteru; Minamiya, Yoshihiro; Hara, Megumi; Nishida, Yuichiro; Takeuchi, Kenji; Wakai, Kenji; Matsuda, Koichi; Murakami, Yoshinori; Shimizu, Kimihiro; Suzuki, Hiroyuki; Saito, Motonobu; Ohtaki, Yoichi; Tanaka, Kazumi; Wu, Tangchun; Wei, Fusheng; Dai, Hongji; Machiela, Mitchell J.; Su, Jian; Kim, Yeul Hong; Oh, In-Jae; Lee, Victor Ho Fun; Chang, Gee-Chen; Tsai, Ying-Huang; Chen, Kuan-Yu; Huang, Ming-Shyan; Su, Wu-Chou; Chen, Yuh-Min; Seow, Adeline; Park, Jae Yong; Kweon, Sun-Seog; Chen, Kun-Chieh; Gao, Yu-Tang; Qian, Biyun; Wu, Chen; Lu, Daru; Liu, Jianjun; Schwartz, Ann G.; Houlston, Richard; Spitz, Margaret R.; Gorlov, Ivan P.; Wu, Xifeng; Yang, Ping; Lam, Stephen; Tardon, Adonina; Chen, Chu; Bojesen, Stig E.; Johansson, Mattias; Risch, Angela; Bickeboeller, Heike; Ji, Bu-Tian; Wichmann, H-Erich; Christiani, David C.; Rennert, Gadi; Arnold, Susanne; Brennan, Paul; McKay, James; Field, John K.; Shete, Sanjay S.; Le Marchand, Loic; Liu, Geoffrey; Andrew, Angeline; Kiemeney, Lambertus A.; Zienolddiny-Narui, Shan; Grankvist, Kjell; Johansson, Mikael; Cox, Angela; Taylor, Fiona; Yuan, Jian-Min; Lazarus, Philip; Schabath, Matthew B.; Aldrich, Melinda C.; Jeon, Hyo-Sung; Jiang, Shih Sheng; Sung, Jae Sook; Chen, Chung-Hsing; Hsiao, Chin-Fu; Jung, Yoo Jin; Guo, Huan; Hu, Zhibin; Burdett, Laurie; Yeager, Meredith; Hutchinson, Amy; Hicks, Belynda; Liu, Jia; Zhu, Bin; Berndt, Sonja I.; Wu, Wei; Wang, Junwen; Li, Yuqing; Choi, Jin Eun; Park, Kyong Hwa; Sung, Sook Whan; Liu, Li; Kang, Chang Hyun; Wang, Wen-Chang; Xu, Jun; Guan, Peng; Tan, Wen; Yu, Chong-Jen; Yang, Gong; Sihoe, Alan Dart Loon; Chen, Ying; Choi, Yi Young; Kim, Jun Suk; Yoon, Ho-Il; Park, In Kyu; Xu, Ping; He, Qincheng; Wang, Chih-Liang; Hung, Hsiao-Han; Vermeulen, Roel C. H.; Cheng, Iona; Wu, Junjie; Lim, Wei-Yen; Tsai, Fang-Yu; Chan, John K. C.; Li, Jihua; Chen, Hongyan; Lin, Hsien-Chih; Jin, Li; Liu, Jie; Sawada, Norie; Yamaji, Taiki; Wyatt, Kathleen; Li, Shengchao A.; Ma, Hongxia; Zhu, Meng; Wang, Zhehai; Cheng, Sensen; Li, Xuelian; Ren, Yangwu; Chao, Ann; Iwasaki, Motoki; Zhu, Junjie; Jiang, Gening; Fei, Ke; Wu, Guoping; Chen, Chih-Yi; Chen, Chien-Jen; Yang, Pan-Chyr; Yu, Jinming; Stevens, Victoria L.; Fraumeni, Joseph F., Jr.; Chatterjee, Nilanjan; Gorlova, Olga Y.; Hsiung, Chao Agnes; Amos, Christopher I.; Shen, Hongbing; Chanock, Stephen J.; Rothman, Nathaniel; Kohno, Takashi; Lan, Qing | NCI, Div Canc Epidemiol & Genet, Rockville, MD 20850 USA; Natl Inst Canc Res, Div Genome Biol, Tokyo, Japan; Aichi Canc Ctr Res Inst, Div Canc Epidemiol & Prevent, Nagoya, Aichi, Japan; Natl Hlth Res Inst, Inst Populat Hlth Sci, Zhunan, Taiwan; Nanjing Med Univ, Sch Publ Hlth, Dept Epidemiol, Nanjing, Peoples R China; Nanjing Med Univ, Collaborat Innovat Ctr Canc Med, Jiangsu Key Lab Canc Biomarkers Prevent & Treatme, Nanjing, Peoples R China; Sinai Hlth, Lunenfeld Tanenbaum Res Inst, Prosserman Ctr Populat Hlth Res, Toronto, ON, Canada; Tianjin Med Univ, Tianjin Med Univ Canc Inst & Hosp, Dept Epidemiol & Biostat, Natl Clin Res Ctr Canc, Tianjin, Peoples R China; Vanderbilt Univ Sch Med, Div Epidemiol, Dept Med, Nashville, TN USA; Vanderbilt Ingram Canc Ctr, Nashville, TN USA; Seoul Natl Univ, Canc Res Inst, Coll Med, Seoul, South Korea; Chinese Acad Med Sci & Peking Union Med Coll, Canc Inst & Hosp, Dept Etiol Carcinogenesis, Beijing, Peoples R China; Chinese Acad Med Sci & Peking Union Med Coll, Canc Inst & Hosp, State Key Lab Mol Oncol, Beijing, Peoples R China; China Med Univ, Sch Publ Hlth, Dept Epidemiol, Shenyang, Peoples R China; China Med Univ, Hosp 1, Dept Clin Epidemiol, Shenyang, Peoples R China; China Med Univ, Hosp 1, Ctr Evidence Based Med, Shenyang, Peoples R China; Shandong Acad Med Sci, Shandong Canc Hosp & Inst, Dept Oncol, Jinan, Peoples R China; Fudan Univ, Sch Life Sci, Minist Educ Key Lab Contemporary Anthropol, Shanghai, Peoples R China; Fudan Univ, Sch Life Sci, State Key Lab Genet Engn, Shanghai, Peoples R China; Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore; Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore, Singapore; Natl Univ Hlth Syst, Singapore, Singapore; Natl Hlth Res Inst, Natl Inst Canc Res, Zhunan, Taiwan; Seoul Natl Univ, Coll Med, Dept Prevent Med, Seoul, South Korea; Chonnam Natl Univ, Med Sch, Dept Prevent Med, Gwangju, South Korea; Guangdong Acad Med Sci, Guangdong Lung Canc Inst, Med Res Ctr, Guangzhou, Peoples R China; Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Canc Ctr, Guangzhou, Peoples R China; Queen Mary Hosp, Dept Pathol, Hong Kong, Peoples R China; Univ North Carolina, Gillings Sch Global Publ Hlth, Dept Biostat, Chapel Hill, NC USA; Georgetown Univ, Med Ctr, Dept Biostat Bioinformat & Biomath, Washington, DC USA; St Jude Childrens Res Hosp, Dept Computat Biol, Memphis, TN USA; Seoul Natl Univ, Grad Sch Publ Hlth, Dept Environm Hlth, Seoul, South Korea; Shanghai Pulm Hosp, Shanghai, Peoples R China; Natl Canc Ctr, Dept Pathol & Clin Labs, Tokyo, Japan; Chonnam Natl Univ, Hwasun Hosp, Lung & Esophageal Canc Clin, Hwasuneup, South Korea; Chonnam Natl Univ, Sch Med, Dept Internal Med, Gwangju, South Korea; Chinese Acad Med Sci & Peking Union Med Coll, Canc Inst & Hosp, Dept Etiol & Carcinogenesis, Beijing, Peoples R China; Univ Hong Kong, Queen Mary Hosp, Dept Med, Hong Kong, Peoples R China; RIKEN Ctr Integrat Med Sci, Lab Genotyping Dev, Yokohama, Kanagawa, Japan; Univ Tokyo, Inst Med Sci, Res Hosp, Ctr Antibody & Vaccine Therapy, Tokyo, Japan; Shiga Univ Med Sci, Dept Med Oncol, Shiga, Japan; Shiga Univ Med Sci, Ctr Canc, Shiga, Japan; Shiga Univ Med Sci, Ctr Adv Med Canc, Shiga, Japan; Sookmyung Womens Univ, Dept Stat, Seoul, South Korea; Sookmyung Womens Univ, Res Inst Nat Sci, Seoul, South Korea; RIKEN Ctr Integrat Med Sci, Lab Stat Anal, Yokohama, Kanagawa, Japan; Tokyo Med & Dent Univ, Dept Thorac Surg, Tokyo, Japan; Tokyo Med & Dent Univ, Dept Resp Med, Tokyo, Japan; Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, New York, NY USA; Japanese Red Cross Med Ctr, Dept Med Oncol, Tokyo, Japan; Natl Canc Ctr, Dept Thorac Surg, Tokyo, Japan; Kanagawa Canc Ctr Res Inst, Mol Pathol & Genet Div, Yokohama, Kanagawa, Japan; Kanagawa Canc Ctr, Dept Thorac Surg, Yokohama, Kanagawa, Japan; Natl Canc Ctr Hosp East, Dept Thorac Oncol, Kashiwa, Chiba, Japan; Natl Canc Ctr Hosp East, Dept Thorac Surg, Kashiwa, Chiba, Japan; Natl Canc Ctr, Div Med Res & Dev, Tokyo, Japan; Akita Univ, Grad Sch Med, Dept Cellular & Organ Pathol, Akita, Japan; Akita Univ, Grad Sch Med, Dept Thorac Surg, Akita, Japan; Saga Univ, Dept Prevent Med, Fac Med, Saga, Japan; Nagoya Univ, Grad Sch Med, Dept Prevent Med, Nagoya, Aichi, Japan; Univ Tokyo, Grad Sch Frontier Sci, Dept Computat Biol & Med Sci, Lab Clin Genome Sequencing, Tokyo, Japan; Univ Tokyo, Inst Med Sci, Div Mol Pathol, Tokyo, Japan; Shinshu Univ, Sch Med Asahi, Dept Surg, Div Gen Thorac Surg, Nagano, Japan; Fukushima Med Univ, Sch Med, Dept Chest Surg, Fukushima, Japan; Fukushima Med Univ, Sch Med, Dept Gastrointestinal Tract Surg, Fukushima, Japan; Gunma Univ Hosp, Dept Integrat Ctr Gen Surg, Gunma, Japan; Huazhong Univ Sci & Technol, Sch Publ Hlth, Inst Occupat Med, Wuhan, Peoples R China; Huazhong Univ Sci & Technol, Sch Publ Hlth, Minist Educ Key Lab Environm & Hlth, Wuhan, Peoples R China; China Natl Environm Monitoring Ctr, Beijing, Peoples R China; Korea Univ, Anam Hosp, Coll Med, Dept Internal Med,Div Oncol Hematol, Seoul, South Korea; Univ Hong Kong, Queen Mary Hosp, Dept Clin Oncol, Hong Kong, Peoples R China; Chung Shan Med Univ, Sch Med, Taichung, Taiwan; Chung Shan Med Univ, Inst Med, Taichung, Taiwan; Chung Shan Med Univ Hosp, Div Pulm Med, Dept Internal Med, Taichung, Taiwan; Natl Chung Hsing Univ, Inst Biomed Sci, Taichung, Taiwan; Taichung Vet Gen Hosp, Div Chest Med, Dept Internal Med, Taichung, Taiwan; Chang Gung Univ, Dept Resp Therapy, Taoyuan, Taiwan; Xiamen Chang Gung Hosp, Dept Pulm & Crit Care, Xiamen, Peoples R China; Natl Taiwan Univ Hosp & Coll Med, Dept Internal Med, Taipei, Taiwan; I Shou Univ, E Da Canc Hosp, Dept Internal Med, Kaohsiung, Taiwan; Kaohsiung Med Univ, Kaohsiung, Taiwan; Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Oncol, Tainan, Taiwan; Natl Yang Ming Chiao Tung Univ, Taipei Vet Gen Hosp, Dept Chest Med, Taipei, Taiwan; Natl Yang Ming Chiao Tung Univ, Sch Med, Taipei, Taiwan; Kyungpook Natl Univ, Med Ctr, Lung Canc Ctr, Daegu, South Korea; Chonnam Natl Univ, Jeonnam Reg Canc Ctr, Hwasun, South Korea; Shanghai Canc Inst, Dept Epidemiol, Shanghai, Peoples R China; Genome Inst Singapore, Agcy Sci Res & Technol, Singapore, Singapore; Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore, Singapore; Karmanos Canc Inst, Detroit, MI USA; Inst Canc Res, Div Genet & Epidemiol, London, England; Inst Clin & Translat Res, Sect Epidemiol & Populat Sci, Dept Med, Houston, TX USA; Zhejiang Univ, Sch Med, Hangzhou, Zhejiang, Peoples R China; Mayo Clin, Dept Hlth Sci Res, Scottsdale, AZ USA; British Columbia Canc Agcy, Vancouver, BC, Canada; Univ Oviedo, IUOPA, Madrid, Spain; CIBERESP, Madrid, Spain; Fred Hutchinson Canc Ctr, Div Publ Hlth Sci, Seattle, WA USA; Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark; Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Clin Biochem, Copenhagen, Denmark; WHO, Int Agcy Res Canc IARC, Lyon, France; German Canc Res Ctr, Heidelberg, Germany; German Ctr Lung Res DZL, Translat Lung Res Ctr Heidelberg TLRC H, Heidelberg, Germany; Univ Salzburg, Salzburg, Austria; Canc Cluster Salzburg, Salzburg, Austria; Univ Med Ctr Goettingen, Gottingen, Germany; Ludwig Maximilians Univ Munchen, Inst Med Informat Biometry & Epidemiol, Munich, Germany; Helmholtz Ctr Munich, Inst Epidemiol, Munich, Germany; Tech Univ Munich, Inst Med Stat & Epidemiol, Munich, Germany; Harvard TH Chan Sch Publ Hlth, Boston, MA USA; Carmel Hosp, Haifa, Israel; Markey Canc Ctr, Lexington, KY USA; Univ Liverpool, Liverpool, Merseyside, England; Univ Texas MD Anderson Canc Ctr, Houston, TX USA; Univ Hawaii, Ctr Canc, Epidemiol Program, Honolulu, HI USA; Princess Margaret Canc Ctr, Toronto, ON, Canada; Norris Cotton Canc Ctr, Lebanon, NH USA; Radboud Univ Nijmegen Med Ctr, Nijmegen, Netherlands; Natl Inst Occupat Hlth, Oslo, Norway; Umea Univ, Dept Med Biosci, Umea, Sweden; Umea Univ, Dept Radiat Sci, Umea, Sweden; Univ Sheffield, Sheffield, S Yorkshire, England; Univ Pittsburgh, Sch Publ Hlth, UPMC Hillman Canc Ctr, Pittsburgh, PA USA; Univ Pittsburgh, Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA USA; Washington State Univ, Coll Pharm, Spokane, WA USA; H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, Tampa, FL USA; Vanderbilt Univ, Med Ctr, Dept Thorac Surg, Div Epidemiol, Nashville, TN USA; Kyungpook Natl Univ, Med Ctr, Canc Res Ctr, Daegu, South Korea; Seoul Natl Univ, Coll Med, Canc Res Inst, Dept Thorac & Cardiovasc Surg, Seoul, South Korea; Huazhong Univ Sci & Technol, Sch Publ Hlth, Tongji Med Coll, Dept Occupat & Environm Hlth, Wuhan, Peoples R China; Huazhong Univ Sci & Technol, Sch Publ Hlth, Tongji Med Coll, Minist Educ Key Lab Environm & Hlth, Wuhan, Peoples R China; Leidos Biomed Res Inc, Canc Genom Res Lab, Rockville, MD USA; Univ Hong Kong, Li Ka Shing LKS Fac Med, Dept Biochem, Hong Kong, Peoples R China; Univ Hong Kong, Li Ka Shing LKS Fac Med, Ctr Genom Sci, Hong Kong, Peoples R China; Genome Inst Singapore, Dept Human Genet, Singapore, Singapore; Seoul Natl Univ, Bundang Hosp, Dept Thorac & Cardiovasc Surg, Seoul, South Korea; Huazhong Univ Sci & Technol, Union Hosp, Ctr Canc, Dept Oncol, Wuhan, Peoples R China; Taipei Med Univ, Coll Med Sci & Technol, PhD Program Translat Med, Taipei, Taiwan; Univ Hong Kong, Li Ka Shing LKS Fac Med, Sch Publ Hlth, Hong Kong, Peoples R China; Univ Liaoning Prov, Key Lab Canc Etiol & Intervent, Shenyang, Peoples R China; Natl Taiwan Univ, Hosp Hsin Chu Branch, Dept Internal Med, Hsinchu, Taiwan; Gleneagles Hong Kong Hosp, Hong Kong, Peoples R China; Korea Univ, Guro Hosp, Coll Med, Dept Internal Med,Div Med Oncol, Seoul, South Korea; Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Seongnam, South Korea; Wuhan Iron & Steel Grp Corp Staff Worker Hosp, Dept Oncol, Wuhan, Peoples R China; Chang Gung Mem Hosp, Dept Pulm & Crit Care, Taoyuan, Taiwan; Univ Utrecht, Inst Risk Assessment Sci IRAS, Div Environm Epidemiol, Utrecht, Netherlands; Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA USA; Queen Elizabeth Hosp, Dept Pathol, Hong Kong, Peoples R China; Qujing Ctr Dis Control & Prevent, Qujing, Peoples R China; Natl Canc Ctr, Natl Canc Ctr Inst Canc Control, Div Cohort Res, Tokyo, Japan; Natl Canc Ctr, Natl Canc Ctr Inst Canc Control, Div Epidemiol, Tokyo, Japan; Natl Canc Inst, Ctr Global Hlth, Bethesda, MD USA; Chung Shan Med Univ, Inst Med, Taichung, Taiwan; Chung Shan Med Univ Hosp, Dept Surg, Div Thorac Surg, Taichung, Taiwan; Acad Sinica, Genom Res Ctr, Taipei, Taiwan; Natl Taiwan Univ Hosp, Dept Internal Med, Taipei, Taiwan; Amer Canc Soc, Lab Serv, Atlanta, GA USA; Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD USA; Johns Hopkins Bloomberg Sch Publ Hlth, Dept Biostat, Baltimore, MD USA; Baylor Coll Med, Dan L Duncan Comprehens Canc Ctr, Houston, TX USA | Bickeböller, Heike/V-2318-2018; Wichmann, Heinz/AAA-5695-2022; Liu, Geoffrey/N-4421-2016; Carrot-Zhang, Jian/K-8618-2019; Chen, KeXin/M-5657-2017; Kim, Tae-You/J-2750-2012; Lilly, Christa/R-6644-2017; Zienolddiny, Shanbeh/O-7392-2015; Chen, Chien-Jen/N-4723-2019; Li, Yuqing/AAR-9383-2021; Yoon, Ho/J-5567-2012; YANG, PAN-CHYR/E-5426-2016; Kim, Min Chul/IYJ-9897-2023; Oh, In-Jae/AAG-5919-2020; Ho, James/C-4308-2009; Jiang, Shih/C-6187-2011; Machiela, Mitchell/H-7335-2019; chen, ying/HHS-8254-2022; Shu, Xiao'Ou/KPA-5613-2024; Kiemeney, Lambertus/D-3357-2009; TOUZE, Emmanuel/HKO-8647-2023; jiang, jun/GWC-9329-2022; Park, MK/GVU-0647-2022; An, Shejuan/A-9573-2014; Rieswijk, Linda/AAJ-3190-2020; Risch, Angela/HTP-4866-2023; Wang, Zhaoming/R-5527-2018; Johansson, Mikael/AAI-7688-2020; Berndt, Sonja/J-8423-2016; Arnold, Susanne/F-6678-2010; Hong, Yun-Chul/J-5725-2012; Ohtaki, Yoichi/HRE-3795-2023; Kim, Young/X-4588-2019; Chang, I-Shou/D-2084-2010; Yang, Ping/E-5355-2011; Kang, Chang-Hyun/J-5364-2012; YATABE, Yasushi/J-6461-2014; Schabath, Matthew/J-3763-2016; Aldrich, Melinda/C-7783-2013; Su, Jian/KEE-9971-2024; Yi-Wen, Chen/G-7275-2016; Liu, Jian/I-5571-2014; Chanock, Stephen/AGL-9345-2022; TARDON, ADONINA/B-6563-2014; Risch, Angela/H-2669-2013; Li, Xingchuan/JFB-4764-2023; Shiraishi, Kouya/MFZ-9526-2025; Li, Xue-Lian/Z-4812-2019; Sung, Jae/AAA-3882-2021; Lin, Honghuang/A-3269-2019; zhu, junjie/JDV-8211-2023; Wang, Junwen/D-3700-2011; chen, Chen/JKJ-2122-2023; Kweon, Sun-Seog/AAZ-4732-2021; Chen, Hongyan/R-8238-2019; Houlston, Richard/AFS-5129-2022; Vermeulen, Roel/F-8037-2011; Zhang, Dong-Yang/HCH-5528-2022; Wu, Yi/F-9420-2018; LIN, HUI-CHEN/AAA-8973-2021; Zheng, Wei/O-3351-2013; Kim, Jin/AET-7817-2022; Liu, Jianjun/AAK-4989-2020; Hsiao, Chin-Fu/E-3993-2010; Takeuchi, Kenji/E-9922-2013; wang, chih-liang/GSD-6038-2022; Chen, Hongyu/Q-3709-2018; Field, John/AAD-5674-2020; Lee, Victor/I-3554-2015; Hamamoto, Ryuji/AAF-9600-2019; Wakai, Kenji/I-7248-2014; Shao, Zhibin/E-3385-2016; Wang, Jiucun/J-8744-2012; Matsuo, Keitaro/H-6758-2019; Zhang, Xuchao/P-9009-2015; Saito, Motonobu/AAQ-3633-2021; Kohno, Takashi/M-8823-2013; Hung, Rayjean/A-7439-2013; Chung, Lap/C-4258-2009; Nishida, Yuichiro/H-8791-2019 | 57193324786; 7202509586; 56090932200; 7401602814; 57209880712; 26643801800; 57556880600; 57216428242; 57211229380; 55584791536; 57217595332; 57216429543; 56393517800; 35335594700; 7401906866; 9044530900; 57221357827; 55511075900; 58483764900; 7201742359; 56452009900; 56742828600; 57226662482; 7403393231; 7410134504; 55569782000; 7403907887; 57202050775; 57196190574; 57966182900; 56658854900; 57188831110; 35346086300; 57202401910; 36700998400; 56799036600; 7006558522; 19336599300; 7401537616; 24315879100; 56242899700; 9736350600; 56440556100; 7005949450; 55907845000; 35201246200; 35376837100; 55716798500; 7402649981; 57216067537; 7004496677; 56723259300; 8628928100; 23018337900; 57201695888; 55342215100; 57418909600; 56353204400; 7003627919; 57218160472; 8690912300; 7103148659; 7401579827; 58880551500; 24576404600; 55450411000; 6701794416; 7403193692; 7102156295; 57207904643; 7202295543; 35519076100; 57211258700; 7403123825; 55212946900; 34573964200; 35327525800; 7404145481; 7404959449; 7406836860; 8237162300; 36618976400; 55523796200; 57210818519; 7202453127; 35309721900; 57205131998; 26644540200; 7410200877; 58754601500; 57209197322; 7402308947; 7402627938; 59609874800; 56440518700; 57154874700; 57202203104; 56153247800; 58360293800; 7003824608; 8674333600; 7404704976; 22954132500; 16231904800; 57223736435; 57208523547; 15770216900; 57944250700; 7103219690; 7004315399; 8236942400; 56437082300; 55193690600; 6602602266; 57026486000; 6506527936; 56447900600; 7003820272; 6603947964; 7102566147; 57202697392; 57216584687; 7005198718; 35298537600; 57217586210; 7201891825; 57647345000; 7003974531; 57222595549; 55875098600; 59883309400; 57200887465; 57713245900; 7005732905; 35746424500; 57211726200; 56605513800; 57203976010; 57204253246; 6603452555; 7006614142; 7201833632; 7404452931; 17344561900; 26025855000; 7202806660; 55446683300; 35754492500; 8392216300; 22949983300; 35379327500; 35381552100; 57210905802; 59652393800; 58062756700; 8551151700; 57202196681; 8950599500; 36027570900; 37107028100; 7408065807; 7202731924; 57295589300; 34770390200; 57201282614; 7407002243; 7006168914; 7401959984; 7404977466; 7405755505; 6603611976; 36106935200; 8547187300; 7601366116; 57391933700; 56438531400; 57214656722; 56003953300; 35486120300; 57291975900; 57200868939; 55781336800; 55713999100; 35995422500; 26028474900; 56603220900; 36523246000; 55011745400; 15723926900; 57359869600; 55279322700; 35307936200; 7102897776; 57169985800; 57169239600; 8624236700; 55874242200; 8644310300; 56468378900; 57192492699; 39362345600; 7102702769; 9233646600; 58288887900; 15065253700; 15727763400; 55286446300; 57215122538; 7501959692; 7403932080; 57226895340; 57201568161; 35374106200; 7004286059; 6603899523; 57202456495; 57203053825; 57218362875; 57216984275; 34572851700; 7201820330; 23970641100 | jianxin.shi@nih.gov;qingl@mail.nih.gov; | NATURE COMMUNICATIONS | NAT COMMUN | 2041-1723 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 14.7 | 5.6 | 3.42 | 2025-06-25 | 31 | 33 | CANCER SUSCEPTIBILITY LOCI; SURFACTANT PROTEIN-B; NEVER-SMOKING WOMEN; TELOMERE LENGTH; GENETIC-VARIANTS; RISK-FACTORS; IDENTIFIES 2; METAANALYSIS; MULTIPLE; HERITABILITY | Adenocarcinoma of Lung; Asia, Eastern; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Lung Neoplasms; Polymorphism, Single Nucleotide; Asia; Far East; acyl coenzyme A desaturase 1; chromosome 16q23; chromosome 8q12; dcbld1 protein; dtnb protein; elf5 protein; fam53b protein; foxp4 protein; gclc protein; gpr37 protein; jaml protein; kctd8 protein; keratinocyte growth factor; linc00674 protein; lung surfactant; mammalian target of rapamycin; mettl10 protein; mpzl3 protein; palm protein; pdgfc protein; phosphatidylinositol 3 kinase; pik3cb protein; protein; protein kinase B; rfx7 protein; secisbp2l protein; telomerase reverse transcriptase; transcriptome; ubiquitin protein ligase NEDD4; unclassified drug; ancestry; cancer; data set; etiology; genome; meta-analysis; smoking; adult; Article; chromosome 11p; chromosome 11q; chromosome 2p11; chromosome 4q32; comparative study; controlled study; disease association; East Asian; effect size; European; expression quantitative trait locus; Far East; female; follow up; gene frequency; gene locus; genetic correlation; genetic identification; genetic risk score; genetic variability; genome-wide association study; human; lung adenocarcinoma; major clinical study; male; medical history; Mendelian randomization analysis; meta analysis; population; smoking; telomere length; genetic predisposition; genetics; genome-wide association study; lung tumor; single nucleotide polymorphism | English | 2023 | 2023-05-26 | 10.1038/s41467-023-38196-z | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Immunotherapy targeting plasma ASM is protective in a mouse model of Alzheimer's disease | Acid sphingomyelinase (ASM) is a sphingolipid metabolizing enzyme that catalyzes the hydrolysis of sphingomyelin to ceramide, and previous work has shown it is upregulated in models of Alzheimer's disease. Here the authors demonstrate in a mouse model of Alzheimer's disease that antibody-based immunotherapy targeting plasma ASM resulted in attenuated neuropathological features by suppressing pathogenic Th17 cells. Acid sphingomyelinase (ASM) has been implicated in neurodegenerative disease pathology, including Alzheimer's disease (AD). However, the specific role of plasma ASM in promoting these pathologies is poorly understood. Herein, we explore plasma ASM as a circulating factor that accelerates neuropathological features in AD by exposing young APP/PS1 mice to the blood of mice overexpressing ASM, through parabiotic surgery. Elevated plasma ASM was found to enhance several neuropathological features in the young APP/PS1 mice by mediating the differentiation of blood-derived, pathogenic Th17 cells. Antibody-based immunotherapy targeting plasma ASM showed efficient inhibition of ASM activity in the blood of APP/PS1 mice and, interestingly, led to prophylactic effects on neuropathological features by suppressing pathogenic Th17 cells. Our data reveals insights into the potential pathogenic mechanisms underlying AD and highlights ASM-targeting immunotherapy as a potential strategy for further investigation. | Choi, Byung Jo; Park, Min Hee; Park, Kang Ho; Han, Wan Hui; Yoon, Hee Ji; Jung, Hye Yoon; Hong, Ju Yeon; Chowdhury, Md Riad; Kim, Kyung Yeol; Lee, Jihoon; Song, Im-Sook; Pang, Minyeong; Choi, Min-Koo; Gulbins, Erich; Reichel, Martin; Kornhuber, Johannes; Hong, Chang-Won; Kim, Changho; Kim, Seung Hyun; Schuchman, Edward H. H.; Jin, Hee Kyung; Bae, Jae-sung | Kyungpook Natl Univ, KNU Alzheimers Dis Res Inst, Daegu, South Korea; Kyungpook Natl Univ, Coll Vet Med, Dept Lab Anim Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Cell & Matrix Res Inst, Dept Physiol, Daegu, South Korea; Kyungpook Natl Univ, Coll Pharm, Vessel Organ Interact Res Ctr VOICE, FOUR Community Based Intelligent Novel Drug Discov, Daegu, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Daegu, South Korea; Dankook Univ, Coll Pharm, Cheonan, South Korea; Univ Duisburg Essen, Dept Mol Biol, Essen, Germany; Friedrich Alexander Univ Erlangen Nuremberg, Dept Psychiat & Psychotherapy, Erlangen, Germany; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Emergency Med, Daegu, South Korea; Hanyang Univ, Coll Med, Dept Neurol, Seoul, South Korea; Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY USA | Kim, Yong-Tae/HQZ-0240-2023; Lee, Ji/T-4913-2017; Kim, Young/T-8521-2019; Kornhuber, Johannes/JAC-7814-2023; Chowdhury, Md. Riad/AAA-1410-2022; Bae, Jae-sung/AAM-8663-2021; KIM, Seung Hyun/T-5133-2017 | 57208899092; 55807755700; 57204158263; 57211890838; 57418719600; 57417768000; 59058563700; 57876552200; 58157583800; 57195979045; 7201564500; 57488599500; 8695781400; 57189933022; 7007019019; 7007179429; 55567018400; 56441824200; 55911799500; 7004364820; 8088145800; 35209510400 | hkjin@knu.ac.kr;jsbae@knu.ac.kr; | NATURE COMMUNICATIONS | NAT COMMUN | 2041-1723 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 14.7 | 5.6 | 0.75 | 2025-06-25 | 7 | 7 | T-CELLS; COGNITIVE FUNCTION; T(H)17 CELLS; TH17 CELLS; SPHINGOMYELINASE; BRAIN; CERAMIDE; NEURODEGENERATION; MONOCYTES; ANTIBODY | Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Disease Models, Animal; Immunotherapy; Mice; Mice, Transgenic; Neurodegenerative Diseases; Sphingomyelin Phosphodiesterase; amyloid beta protein; immunoglobulin G antibody; interleukin 17 antibody; presenilin 1; sphingomyelin phosphodiesterase; amyloid beta protein; amyloid precursor protein; sphingomyelin phosphodiesterase; blood; disease; enzyme; enzyme activity; genetic differentiation; plasma; Alzheimer disease; animal cell; animal experiment; animal model; animal tissue; Article; controlled study; enzyme inhibition; female; immunotherapy; lymphocyte differentiation; male; mouse; mouse model; neuropathology; neuroprotection; nonhuman; prophylaxis; Th17 cell; Alzheimer disease; animal; degenerative disease; disease model; genetics; immunotherapy; pathology; transgenic mouse | English | 2023 | 2023-03-24 | 10.1038/s41467-023-37316-z | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Kondo interaction in FeTe and its potential role in the magnetic order | The Kondo hybridization typically occurs in heavy-fermion systems containing f electrons, although recently it has been reported in d-electron systems. Kim et al. report spectroscopic evidence of the Kondo hybridization in FeTe and discuss it role in the mechanism of the magnetic order. Finding d-electron heavy fermion states has been an important topic as the diversity in d-electron materials can lead to many exotic Kondo effect-related phenomena or new states of matter such as correlation-driven topological Kondo insulator. Yet, obtaining direct spectroscopic evidence for a d-electron heavy fermion system has been elusive to date. Here, we report the observation of Kondo lattice behavior in an antiferromagnetic metal, FeTe, via angle-resolved photoemission spectroscopy, scanning tunneling spectroscopy and transport property measurements. The Kondo lattice behavior is represented by the emergence of a sharp quasiparticle and Fano-type tunneling spectra at low temperatures. The transport property measurements confirm the low-temperature Fermi liquid behavior and reveal successive coherent-incoherent crossover upon increasing temperature. We interpret the Kondo lattice behavior as a result of hybridization between localized Fe 3d(xy) and itinerant Te 5p(z) orbitals. Our observations strongly suggest unusual cooperation between Kondo lattice behavior and long-range magnetic order. | Kim, Younsik; Kim, Min-Seok; Kim, Dongwook; Kim, Minjae; Kim, Minsoo; Cheng, Cheng-Maw; Choi, Joonyoung; Jung, Saegyeol; Lu, Donghui; Kim, Jong Hyuk; Cho, Soohyun; Song, Dongjoon; Oh, Dongjin; Yu, Li; Choi, Young Jai; Kim, Hyeong-Do; Han, Jung Hoon; Jo, Younjung; Shim, Ji Hoon; Seo, Jungpil; Huh, Soonsang; Kim, Changyoung | Inst for Basic Sci Korea, Ctr Correlated Electron Syst, Seoul 08826, South Korea; Seoul Natl Univ, Dept Phys & Astron, Seoul 08826, South Korea; DGIST, Dept Emerging Mat Sci, Daegu 42988, South Korea; Pohang Univ Sci & Technol POSTECH, Dept Chem, Pohang 37673, South Korea; Korea Inst Adv Study, Seoul 02455, South Korea; Natl Synchrotron Radiat Res Ctr, Hsinchu 30076, Taiwan; Kyungpook Natl Univ, Dept Phys, Daegu 41566, South Korea; SLAC Natl Accelerator Lab, Stanford Synchrotron Radiat Light Source, Menlo Pk, CA 94025 USA; Yonsei Univ, Dept Phys, Seoul 03021, South Korea; Chinese Acad Sci, Shanghai Inst Microsyst & Informat Technol, Ctr Excellence Superconducting Elect, State Key Lab Funct Mat Informat, Shanghai 200050, Peoples R China; Chinese Acad Sci, Beijing Natl Lab Condensed Matter Phys, Beijing 100190, Peoples R China; Chinese Acad Sci, Inst Phys, Beijing 100190, Peoples R China; Univ Chinese Acad Sci, Sch Phys Sci, Beijing 100049, Peoples R China; Songshan Lake Mat Lab, Dongguan 523808, Guangdong, Peoples R China; Pohang Accelerator Lab, XFEL Beamline Div, Pohang 37673, South Korea; Sungkyunkwan Univ, Dept Phys, Suwon 16419, South Korea; MIT, Dept Phys, Cambridge, MA 02139 USA | ; Yu, Liang/G-2574-2013; Kim, Changyoung/AAS-4221-2021; Kim, Jun/G-8861-2012; Kim, Jeehoon/K-3763-2012; Kim, TaeHeon/KIC-2380-2024; Kim, Soo-Yeon/ADR-9663-2022; Han, Jung-Hoon/AAE-7911-2019 | 57218459973; 57218082191; 57075225100; 56084817400; 59072942100; 23468425500; 57199099536; 57222181997; 7403079713; 57193568510; 57193743010; 21743444000; 57214245779; 55737417100; 26535632200; 8217995100; 36487931400; 13502586500; 57281457100; 9640324600; 57190669651; 35264213600 | sshuhss@gmail.com;changyoung@snu.ac.kr; | NATURE COMMUNICATIONS | NAT COMMUN | 2041-1723 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 14.7 | 5.6 | 1.39 | 2025-06-25 | 14 | 13 | SUPERCONDUCTIVITY; FRUSTRATION | iron; tellurium; detection method; electron; inorganic compound; instrumentation; low temperature; Article; chemical interaction; chemical structure; comparative study; energy; hybridization; inductively coupled plasma mass spectrometry; kondo interaction; magnetism; photoelectron spectroscopy; photon; scanning tunneling spectroscopy; surface property; synchrotron radiation; temperature dependence | English | 2023 | 2023-07-12 | 10.1038/s41467-023-39827-1 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Long-wave infrared transparent sulfur polymers enabled by symmetric thiol cross-linker | Infrared (IR) transmissive polymeric materials for optical elements require a balance between their optical properties, including refractive index (n) and IR transparency, and thermal properties such as glass transition temperature (T-g). Achieving both a high refractive index (n) and IR transparency in polymer materials is a very difficult challenge. In particular, there are significant complexities and considerations to obtaining organic materials that transmit in the long-wave infrared (LWIR) region, because of high optical losses due to the IR absorption of the organic molecules. Our differentiated strategy to extend the frontiers of LWIR transparency is to reduce the IR absorption of the organic moieties. The proposed approach synthesized a sulfur copolymer via the inverse vulcanization of 1,3,5-benzenetrithiol (BTT), which has a relatively simple IR absorption because of its symmetric structure, and elemental sulfur, which is mostly IR inactive. This strategy resulted in approximately 1mm thick windows with an ultrahigh refractive index (n(av)>1.9) and high mid-wave infrared (MWIR) and LWIR transmission, without any significant decline in thermal properties. Furthermore, we demonstrated that our IR transmissive material was sufficiently competitive with widely used optical inorganic and polymeric materials. | Lee, Miyeon; Oh, Yuna; Yu, Jaesang; Jang, Se Gyu; Yeo, Hyeonuk; Park, Jong-Jin; You, Nam-Ho | Korea Inst Sci & Technol KIST, Carbon Composite Mat Res Ctr, Wonju 55324, South Korea; Chonnam Natl Univ, Dept Polymer Engn, Gwangju 61186, South Korea; Korea Inst Sci & Technol KIST, Inst Adv Composite Mat Res Ctr, Wonju 55324, South Korea; Korea Inst Sci & Technol KIST, Funct Composite Mat Res Ctr, Wonju 55324, South Korea; Kyungpook Natl Univ, Dept Chem Educ, Daegu 41566, South Korea | ; yeo, hyeonuk/G-7890-2017; Yeo, Hyeonuk/AHE-0397-2022 | 57214328880; 57206717431; 36669801400; 7402219010; 55324816500; 59871668100; 55204428300 | polymer@kist.re.kr; | NATURE COMMUNICATIONS | NAT COMMUN | 2041-1723 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 14.7 | 5.6 | 4.17 | 2025-06-25 | 36 | 39 | REFRACTIVE-INDEX POLYMERS; ELEMENTAL SULFUR; INVERSE VULCANIZATION | 1,3,5 benzenetrithiol; carbon; copolymer; hydrogen; polymer; sulfur; thiol; thiol derivative; unclassified drug; absorption; organic matter; polymer; refractive index; sulfur; thiol; transparency; Article; asymmetric synthesis; cross linking; elemental analysis; glass transition temperature; infrared radiation; long wave infrared; mid wave infrared; optics; refraction index | English | 2023 | 2023-05-19 | 10.1038/s41467-023-38398-5 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Lung-specific MCEMP1 functions as an adaptor for KIT to promote SCF-mediated mast cell proliferation | Mast cells are activated and proliferate during allergic reactions which can involve mast cell specific proteins. Here the authors show that mast cell-expressed membrane protein1 (MCEMP1) is an adaptor for KIT to promote SCF mediated mast cell proliferation and lack of MCEMP1 reduces inflammation in mouse asthma models. Lung mast cells are important in host defense, and excessive proliferation or activation of these cells can cause chronic inflammatory disorders like asthma. Two parallel pathways induced by KIT-stem cell factor (SCF) and Fc epsilon RI-immunoglobulin E interactions are critical for the proliferation and activation of mast cells, respectively. Here, we report that mast cell-expressed membrane protein1 (MCEMP1), a lung-specific surface protein, functions as an adaptor for KIT, which promotes SCF-mediated mast cell proliferation. MCEMP1 elicits intracellular signaling through its cytoplasmic immunoreceptor tyrosine-based activation motif and forms a complex with KIT to enhance its autophosphorylation and activation. Consequently, MCEMP1 deficiency impairs SCF-induced peritoneal mast cell proliferation in vitro and lung mast cell expansion in vivo. Mcemp1-deficient mice exhibit reduced airway inflammation and lung impairment in chronic asthma mouse models. This study shows lung-specific MCEMP1 as an adaptor for KIT to facilitate SCF-mediated mast cell proliferation. | Choi, Youn Jung; Yoo, Ji-Seung; Jung, Kyle; Rice, Logan; Kim, Dokyun; Zlojutro, Violetta; Frimel, Matthew; Madden, Evan; Choi, Un Yung; Foo, Suan-Sin; Choi, Younho; Jiang, Zhongyi; Johnson, Holly; Kwak, Mi-Jeong; Kang, Seokmin; Hong, Brian; Seo, Gil Ju; Kim, Stephanie; Lee, Shin-Ae; Amini-Bavil-Olyaee, Samad; Maazi, Hadi; Akbari, Omid; Asosingh, Kewal; Jung, Jae U. | Cleveland Clin, Dept Canc Biol, Infect Biol Program, Cleveland, OH 44195 USA; Cleveland Clin, Lerner Res Inst, Global Ctr Pathogen & Human Hlth Res, Cleveland, OH 44195 USA; Univ Southern Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA; Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat BioRes Grp, Daegu 41566, South Korea; Cleveland Clin, Lerner Res Inst, Dept Inflammat & Immun, Cleveland, OH 44195 USA; Cleveland Clin, Florida Res & Innovat Ctr, Port St Lucie, FL 34987 USA; Amgen Inc, Cellular Sci Dept, Biosafety Dev Grp, One Amgen Ctr Dr, Thousand Oaks, CA 91320 USA | ; Jiang, Zhongyi/MCY-3352-2025; Akbari, Omid/T-3846-2019; Yoo, Ji-Seung/KHD-6177-2024; Hong, Brian/T-3132-2019; Choi, Un Yung/GWZ-5421-2022; Kim, Dokyun/JPA-0437-2023; Maazi, Hadi/A-6368-2012 | 55654689000; 59510752300; 57204969183; 58179930400; 58043784300; 57558629100; 57210859944; 58179796100; 57194039907; 54786398300; 7404777496; 57215531422; 58179930500; 56007288800; 58179662600; 58179662700; 56034961300; 57194043175; 57190621348; 8632780700; 36572219400; 57204342676; 6603918376; 7402897118 | CHOIY4@ccf.org;JUNGJ@ccf.org; | NATURE COMMUNICATIONS | NAT COMMUN | 2041-1723 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 14.7 | 5.6 | 0.64 | 2025-06-25 | 5 | 6 | MULTIPLE FEATURES; STRUCTURAL BASIS; GENE-EXPRESSION; ASTHMA; ACTIVATION; IMATINIB; PATHWAYS; INFLAMMATION; RECRUITMENT; HOMEOSTASIS | Animals; Asthma; Cell Proliferation; Lung; Mice; Proto-Oncogene Proteins c-kit; Stem Cell Factor; cell protein; mast cell expressed membrane protein1; membrane protein; microphthalmia associated transcription factor; ovalbumin; unclassified drug; stem cell factor; stem cell factor receptor; antibody; asthma; cell component; chemical reaction; membrane; animal cell; animal experiment; animal model; animal tissue; Article; asthma; autophosphorylation; B6D2F1 mouse; calcium cell level; calcium mobilization assay; carboxy terminal sequence; cell proliferation; coimmunoprecipitation; controlled study; CRISPR-CAS9 system; degranulation assay; ectopic expression; flow cytometry; gene expression; GST pull-down; HMC-1 cell line; human; immunoblotting; immunohistochemistry; immunoprecipitation; immunoreceptor tyrosine based activation motif; intracellular signaling; MAPK signaling; mast cell; mast cell degranulation; mouse; nonhuman; peritoneum mast cell; phosphorylation; plasmid; protein expression; protein phosphorylation; RAW 264.7 cell line; real time polymerase chain reaction; RNA sequencing; signal transduction; stop codon; animal; cell proliferation; lung; metabolism | English | 2023 | 2023-04-11 | 10.1038/s41467-023-37873-3 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Methionine consumption by cancer cells drives a progressive upregulation of PD-1 expression in CD4 T cells | Programmed cell death protein 1 (PD-1), expressed on tumor-infiltrating T cells, is a T cell exhaustion marker. The mechanisms underlying PD-1 upregulation in CD4 T cells remain unknown. Here we develop nutrient-deprived media and a conditional knockout female mouse model to study the mechanism underlying PD-1 upregulation. Reduced methionine increases PD-1 expression on CD4 T cells. The genetic ablation of SLC43A2 in cancer cells restores methionine metabolism in CD4 T cells, increasing the intracellular levels of S-adenosylmethionine and yielding H3K79me2. Reduced H3K79me2 due to methionine deprivation downregulates AMPK, upregulates PD-1 expression and impairs antitumor immunity in CD4 T cells. Methionine supplementation restores H3K79 methylation and AMPK expression, lowering PD-1 levels. AMPK-deficient CD4 T cells exhibit increased endoplasmic reticulum stress and Xbp1s transcript levels. Our results demonstrate that AMPK is a methionine-dependent regulator of the epigenetic control of PD-1 expression in CD4 T cells, a metabolic checkpoint for CD4 T cell exhaustion. The deprivation of amino acids in the tumor microenvironment affects T cell survival and activation. Here the authors show that reduced levels of methionine are associated with PD1 upregulation in CD4+ T cells and that methionine supplementation promotes CD4+ T cell dependent anti-tumor immune responses. | Pandit, Mahesh; Kil, Yun-Seo; Ahn, Jae-Hee; Pokhrel, Ram Hari; Gu, Ye; Mishra, Sunil; Han, Youngjoo; Ouh, Yung-Taek; Kang, Ben; Jeong, Myeong Seon; Kim, Jong-Oh; Nam, Joo-Won; Ko, Hyun-Jeong; Chang, Jae-Hoon | Yeungnam Univ, Coll Pharm, Gyongsan 38541, Gyeongsangbukdo, South Korea; Kangwon Natl Univ, Dept Pharm, Chunchon 24341, South Korea; Kangwon Natl Univ, Sch Med, Dept Obstet & Gynecol, Chunchon 24289, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pediat, 68 Gukchaebosang Ro, Daegu 41944, South Korea; Korea Basic Sci Inst KBSI, Chuncheon Ctr, Chunchon 24341, South Korea; Kangwon Natl Univ, Dept Biochem, Chunchon 24341, South Korea | 康, 奔/JMQ-0812-2023; Ouh, Yung-Taek/HNC-0103-2023; Kim, Ji-Young/HJA-5494-2022 | 57215575572; 55697856900; 56517379700; 57299414200; 57211247435; 58237752800; 58236545400; 55387186000; 57194823199; 56720070400; 57209837747; 8883246800; 7201926360; 24782066600 | hjko@kangwon.ac.kr;jchang@yu.ac.kr; | NATURE COMMUNICATIONS | NAT COMMUN | 2041-1723 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 14.7 | 5.6 | 3.53 | 2025-06-25 | 34 | 34 | ER STRESS SENSOR; GENOME BROWSER; AMINO-ACIDS; ENCODE DATA; RESPONSES; METABOLISM; MELANOMA; IMMUNITY; PLATFORM | AMP-Activated Protein Kinases; Animals; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Female; Methionine; Mice; Mice, Knockout; Neoplasms; Programmed Cell Death 1 Receptor; Racemethionine; Up-Regulation; ademetionine; histone H3; hydroxymethylglutaryl coenzyme A reductase kinase; methionine; programmed death 1 receptor; X box binding protein 1; hydroxymethylglutaryl coenzyme A reductase kinase; methionine; programmed death 1 receptor; ablation; amino acid; cancer; gene expression; immunity; metabolism; protein; amino acid metabolism; animal cell; animal experiment; animal model; Article; cancer cell; CD4+ T lymphocyte; cell level; cell metabolism; controlled study; down regulation; endoplasmic reticulum stress; epigenetics; female; human; human cell; knockout gene; mouse; nonhuman; protein expression; supplementation; T cell exhaustion; tumor immunity; tumor microenvironment; upregulation; animal; CD8+ T lymphocyte; knockout mouse; metabolism; neoplasm; upregulation | English | 2023 | 2023-05-05 | 10.1038/s41467-023-38316-9 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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