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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Numb-associated kinases regulate sandfly-borne Toscana virus entry | Sandfly-borne Toscana virus (TOSV) is an enveloped tri-segmented negative single-strand RNA Phlebovirus. It is an emerging virus predominantly endemic in southwestern Europe and Northern Africa. Although TOSV infection is typically asymptomatic or results in mild febrile disease, it is neurovirulent and ranks among the three most common causes of summer meningitis in certain regions. Despite this clinical significance, our understanding of the molecular aspects and host factors regulating phlebovirus infection is limited. This study characterized the early steps of TOSV infection. Our findings reveal that two members of the Numb-associated kinases family of Ser/Thr kinases, namely adaptor-associated kinase 1 (AAK1) and cyclin G-associated kinase (GAK), play a role in regulating the early stages of TOSV entry. FDA-approved inhibitors targeting these kinases demonstrated significant inhibition of TOSV infection. This study suggests that AAK1 and GAK represent druggable targets for inhibiting TOSV infection and, potentially, related Phleboviruses. | Moalem, Yarden; Katz, Rodolfo; Subramaniam, Anand G.; Malis, Yehonathan; Yaffe, Yakey; Borenstein-Auerbach, Nofit; Tadmor, Keshet; Raved, Roey; Maoz, Ben M.; Yoo, Ji Seung; Lustig, Yaniv; Luxenburg, Chen; Perlson, Eran; Einav, Shirit; Sklan, Ella H. | Tel Aviv Univ, Fac Med & Hlth Sci, Dept Clin Microbiol & Immunol, IL-6997801 Tel Aviv, Israel; Tel Aviv Univ, Fac Med & Hlth Sci, Dept Physiol & Pharmacol, Tel Aviv, Israel; Tel Aviv Univ, Fac Med & Hlth Sci, Dept Pathol, Tel Aviv, Israel; Tel Aviv Univ, Drimmer Fischler Family Stem Cell Core Lab Regener, Tel Aviv, Israel; Tel Aviv Univ, Fac Med & Hlth Sci, Dept Cell & Dev Biol, Tel Aviv, Israel; Tel Aviv Univ, Sagol Sch Neurosci, Tel Aviv, Israel; Tel Aviv Univ, George S Wise Fac Life Sci, Sch Neurobiol Biochem & Biophys, Tel Aviv, Israel; Tel Aviv Univ, Dept Biomed Engn, Tel Aviv, Israel; Kyungpook Natl Univ, Sch Life Sci, FOUR KNU Creat Biores Grp BK21, Daegu, South Korea; Chaim Sheba Med Ctr, Minist Hlth, Cent Virol Lab, Tel Hashomer, Israel; Tel Aviv Univ, Sch Publ Hlth, Sch Med, Tel Aviv, Israel; Stanford Univ, Dept Med, Div Infect Dis & Geog Med, Stanford, CA USA; Stanford Univ, Dept Microbiol & Immunol, Stanford, CA USA; Chan Zuckerberg Biohub, San Francisco, CA USA | ; Yoo, Ji-Seung/KHD-6177-2024; Sklan, Ella/MSW-8581-2025 | 57201340225; 59238981700; 59238918700; 57751988300; 34067919500; 56069658600; 57226112298; 59238971700; 42461922500; 59510752300; 57110295000; 8103345700; 6507618833; 23099859000; 6507052815 | sklan@post.tau.ac.il; | EMERGING MICROBES & INFECTIONS | EMERG MICROBES INFEC | 2222-1751 | 13 | 1 | SCIE | IMMUNOLOGY;INFECTIOUS DISEASES;MICROBIOLOGY | 2024 | 7.5 | 4.7 | 0.62 | 2025-05-07 | 1 | 1 | Toscana virus; Sandfly; Phleboviruses; Bunyaviruses; viral entry | MEDIATED ENDOCYTOSIS; CLATHRIN; INHIBITOR; AP2; PHOSPHORYLATION; TRAFFICKING; DYNASORE; SUBUNIT; BINDING; CELLS | Bunyaviruses; Phleboviruses; Sandfly; Toscana virus; viral entry | Animals; Cell Line; Humans; Protein Serine-Threonine Kinases; Sandfly fever Naples virus; Virus Internalization; adaptor associated kinase 1; clathrin; cyclin g associated kinase; erlotinib; gefitinib; phosphotransferase; ribavirin; short hairpin RNA; sunitinib; tubulin; unclassified drug; virus RNA; AAK1 protein, human; protein serine threonine kinase; animal cell; Article; cell viability; comparative study; controlled study; drug effect; endocytosis; endosomal pH; Huh-7 cell line; human; human cell; keratinocyte; molecular weight; mouse; nonhuman; Phlebovirus infection; plaque assay; RNA analysis; RNA extraction; Toscana virus; Toscana virus infection; Vero cell line; virus entry; animal; cell line; genetics; metabolism; Sandfly fever Naples virus | English | 2024 | 2024-12-31 | 10.1080/22221751.2024.2382237 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Numerical investigation of thermomechanical behavior of Yttrium barium zirconate-coated aluminum alloy piston in an internal combustion engine | Increasing engine power to volume density is under investigation and being analysed extensively. Turbocharger, which is used to boost volumetric efficiency, also raises cylinder temperature and pressure, thus resulting in thermal distortions and reducing clearances in tribo-contacts, thereby compromising engine life. Thermal barrier coatings (TBCs) have shown potential to provide remedies to reduce heat losses, hazardous emissions, and heat flow toward the piston skirt in an internal combustion engine. In this study, a detailed thermo-mechanical analysis was performed for a diesel engine piston with a novel yttrium barium zirconate (YBZ) coating and then compared with other TBCs with varying thicknesses. The results revealed a notable decrease in piston substrate surface temperature when coated with various TBCs, with YBZ coating demonstrating superior performance over others. The 0.2 mm coating of YBZ-coated piston exhibited significant reductions of 15% and 10.3% in temperature and thermal stress respectively, thus enhancing piston durability. The better performance of the novel YBZ coating could be attributed to its stable thermal and elastic properties and lower thermal conductivity than other TBC materials. YBZ coating provides a promising solution to improve engine efficiency while extending engine life, making it an attractive option for the automotive industry. | Khan, Shah Nawaz; Usman, Ali; Afzal, Muhammad Shakeel; Tanveer, Muhammad; Liwicki, Marcus; Almqvist, Andreas; Park, Cheol Woo | Kyungpook Natl Univ, Sch Mech Engn, 80 Daehakro, Daegu 41566, South Korea; Lulea Univ Technol, EISLAB Machine Learning, S-97187 Lulea, Sweden; Tampere Univ, Fac Built Environm, Struct Engn, Tampere 33720, Finland; COMSATS Univ Islamabad, Dept Mech Engn, Wah Cantt, Pakistan; Lulea Univ Technol, Div Machine Element, S-97187 Lulea, Sweden | Almqvist, Andreas/GYR-3923-2022; Tanveer, Muhammad/AAO-9360-2021 | 57203224284; 42062484500; 57200092141; 23486949200; 14021418000; 8367337400; 7408416474 | chwoopark@knu.ac.kr; | APPLIED THERMAL ENGINEERING | APPL THERM ENG | 1359-4311 | 1873-5606 | 236 | SCIE | ENERGY & FUELS;ENGINEERING, MECHANICAL;MECHANICS;THERMODYNAMICS | 2024 | 6.9 | 4.7 | 6.13 | 2025-05-07 | 14 | 22 | Diesel engine; Piston; Thermal barrier coating; Substrate surface temperature; Thermal stress | THERMAL BARRIER COATINGS; STRESS; TEMPERATURE; FATIGUE | Diesel engine; Piston; Substrate surface temperature; Thermal barrier coating; Thermal stress | Aluminum alloys; Aluminum coatings; Automotive industry; Combustion; Diesel engines; Efficiency; Engine pistons; Surface properties; Thermal barrier coatings; Thermal conductivity; Thermal stress; Aluminum alloy piston; Engine life; Engine power; Numerical investigations; Performance; Substrate surface temperature; Thermo-mechanical behaviors; Volume density; Volumetric efficiency; Zirconates; Atmospheric temperature | English | 2024 | 2024-01-05 | 10.1016/j.applthermaleng.2023.121603 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Optimising heat sink performance with porous media-PCM integration: An experimental investigation | Miniaturisation of semiconductor devices surges thermal management challenges, making effective heat dissipation crucial for durability and optimal performance. This study addresses the issue of excessive heat in semiconductors by investigating advanced cooling solutions using nickel foam -phase change material (PCM) composites. Experimental analysis of various configurations of these composites is conducted, focusing on two types of PCMs (RT-35HC and RT-54HC) with volume fractions of 0.6 and 0.8, integrated into heat sinks. The methodology involves monitoring the junction temperature of the heat sinks under varying heat flux conditions (0.8 to 2.4 kW/m(2)) over thermal charging and discharging cycles. The findings reveal a significant reduction in peak temperature, with the RT-35HC-nickel foam configuration (0.8 vol fraction) achieving a 24.9 % decrease at 1.6 kW/m(2) heat flux. This configuration also extended the operation time by 3.84 times at a critical temperature of 65 degrees C. Comparatively, the RT-54HC composite at the same fraction reduced the peak temperature by 21.4 % under a 2.4 kW/m(2) heat flux. These results demonstrate the effectiveness of PCM-based heat sinks in the charging and discharging phases, with the best performance observed in the RT-35HC with a 0.8 PCM fraction. In addition to a viable solution to thermal management in electronic devices, this study also contributes suggestively to the knowledge of PCM integration in heat sink technology for enhanced cooling efficiency. | Rehman, Tauseef-ur; Park, Cheol Woo | Kyungpook Natl Univ, Sch Mech Engn, Daegu 41566, South Korea | Rehman, Tauseef-ur/AAE-3086-2022 | 57159403400; 7408416474 | chwoopark@knu.ac.kr; | APPLIED THERMAL ENGINEERING | APPL THERM ENG | 1359-4311 | 1873-5606 | 242 | SCIE | ENERGY & FUELS;ENGINEERING, MECHANICAL;MECHANICS;THERMODYNAMICS | 2024 | 6.9 | 4.7 | 5.16 | 2025-05-07 | 19 | 22 | Heat sink; Heat transfer; Metal foam; PCM; Thermal management | PHASE-CHANGE MATERIAL; THERMAL MANAGEMENT; GRAPHITE; FOAM; COMPOSITES | Heat sink; Heat transfer; Metal foam; PCM; Thermal management | English | 2024 | 2024-04-01 | 10.1016/j.applthermaleng.2024.122506 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Piperlongumine regulates genes involved in the skin barrier in epidermal keratinocyte HaCaT cells | Given that the skin is the largest tissue in the human body, performing external barrier functions with innate and adaptive immunity and undergoing substantial changes during aging, it is under investigation as a major target of various bioactive molecules. In the present study, we examined the biological activity of the senolytic piperlongumine by analyzing alterations in mRNA expression of notable skin genes using transformed aneuploid immortal epidermal keratinocytes, HaCaT cells. We observed that piperlongumine increased the mRNA expression of genes playing critical roles in skin barrier function. In addition, piperlongumine increased expression enzymes involved in the synthesis of ceramide, a major component of intercellular lipids. Furthermore, we measured the protein levels of various cytokines secreted by epidermal keratinocytes and found changes in the release of GRO-alpha beta gamma, CCL5, and MCP1. Additionally, we observed that piperlongumine treatment modulated the expression of keratinocyte-specific aging markers and influenced telomerase activity. Based on these findings, piperlongumine could regulate the physiological activity of epidermal keratinocytes to induce beneficial effects in human skin by regulating important skin-related genes. | Lee, Kyung-Ha; Kang, Deok Gyeong; Kim, Dae-Wook; Do, Hwan-Kwon; Kim, Do-Yeon; Kim, Wanil | Pusan Natl Univ, Dept Mol Biol, Busan, South Korea; Gyeongsang Natl Univ, Sch Med, Dept Biochem, Dept Convergence Med Sci, Jinju, South Korea; Gyeongsang Natl Univ, Inst Med Sci, Sch Med, Jinju, South Korea; Inje Univ, Haeundae Paik Hosp, Dept Orthoped Surg, Coll Med, Busan, South Korea; Dongnam Inst Radiol & Med Sci, Canc Ctr, Dept Phys Med & Rehabil, Busan, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Pharmacol, Daegu, South Korea | Kim, Do-Yeon/AET-3021-2022; KIM, DAE-WOOK/JFX-7131-2023; Lee, Kyung-Ha/GRY-2640-2022 | 54967786000; 59202778700; 57196473079; 57194657282; 57203012542; 7405813437 | dykim82@knu.ac.kr;wkim@gnu.ac.kr; | ANIMAL CELLS AND SYSTEMS | ANIM CELLS SYST | 1976-8354 | 2151-2485 | 28 | 1 | SCIE | CELL BIOLOGY;ZOOLOGY | 2024 | 3.2 | 4.7 | 0 | 2025-05-07 | 0 | 0 | Piperlongumine; keratinocyte; skin barrier gene; inflammation | CERAMIDE SYNTHESIS; CHEMOKINES; PROLIFERATION; RECRUITMENT; DEFICIENCY; EXPRESSION; PHENOTYPE; REVEALS; GROWTH; CCL5 | inflammation; Piperlongumine; keratinocyte; skin barrier gene | English | 2024 | 2024-12-31 | 10.1080/19768354.2024.2361144 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Shell and tube heat exchange comparison with gravitational water vortex flow configuration | As a recent addition to the heat exchanger family, gravitational water vortex heat exchangers may be considered a potential alternative to shell-and-tube heat exchangers in the process industry. Their shared reliance on the turbulent fluid flow for heat transfer and comparable sizes indicates the need to compare the two thermal systems in terms of input energy requirement, heat exchange effectiveness, temperature distribution, log-mean temperature difference and overall heat transfer coefficient. The present study reports an experimental comparison of the performance of a shell-and-tube heat exchanger with a gravitational water vortex heat exchanger for the same heat exchange area, mass flowrates and reference temperatures. The validation of the experiments is supported by the analytical results for both heat exchangers. The experimental findings highlight the importance of the presence of air core in the gravitational water vortex heat exchanger, which performs 40 % better than in the absence of air core. Moreover, the same air core provides support in outperforming the shell-and-tube configuration by a margin of 22 % and 24 % more heat transfer rate for the same hot-side inlet temperatures of 313 K and 323 K, respectively. The study concludes that the gravitational water vortex heat exchanger performs better than the shell-and-tube heat exchanger at high inlet flow rates, whereas the latter is more effective in terms of log-mean temperature difference with better heat loss counter measures. | Khan, Ali Ul Atas; Cheema, Taqi Ahmad; Rizwan, Hafiz Muhammad; Ullah, Rizwan; Tayyab, Muhammad; Park, Cheol Woo | GIK Inst Engn Sci & Technol, Fac Mech Engn, Topi 23460, Pakistan; Kyungpook Natl Univ, Sch Mech Engn, 80 Daehak Ro, Daegu 41566, South Korea | Tayyab, Muhammad/HIR-8111-2022 | 58725443700; 36522492600; 57136721300; 57534907400; 58793345200; 7408416474 | tacheema@giki.edu.pk;chwoopark@knu.ac.kr; | APPLIED THERMAL ENGINEERING | APPL THERM ENG | 1359-4311 | 1873-5606 | 238 | SCIE | ENERGY & FUELS;ENGINEERING, MECHANICAL;MECHANICS;THERMODYNAMICS | 2024 | 6.9 | 4.7 | 1.61 | 2025-05-07 | 6 | 6 | Vortex heat exchanger; Shell -and -tube heat exchanger; Baffles; Energy balance; Air core; Temperature distribution | TRANSFER ENHANCEMENT | Air core; Baffles; Energy balance; Shell-and-tube heat exchanger; Temperature distribution; Vortex heat exchanger | Heat exchangers; Heat transfer; Shells (structures); Thermal logging; Tubes (components); Vortex flow; Air-core; Baffle; Flow configurations; Heat-exchange; Log-mean temperature differences; Process industries; Shell-and- tube heat exchangers; Shell-and-tube; Turbulent fluid flow; Vortex heat exchanger; Temperature distribution | English | 2024 | 2024-02-01 | 10.1016/j.applthermaleng.2023.122000 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Stable sodium-metal batteries with a hierarchical structured electrode toward reversible confinement of Na dendrites | Sodium metal is a promising candidate for the future of rechargeable batteries. However, a significant problem, that is, the growth of sodium dendrites, which are uncontrolled microscopic structures that reduce battery performance and stability, remains unaddressed. To resolve this issue, the development of three-dimensional (3D) nanostructured hosts to prevent dendrite growth and cease the buildup of inactive sodium has been proposed. However, research on developing an uncomplicated process to design these 3D hosts is currently lacking. In this study, we used the ice-templating method to form a self-supporting 3D hierarchical porous structure using a graphene oxide dispersion. This approach offers significant benefits in terms of scalability and costeffectiveness. The resulting porous design offers numerous nucleation sites, which in turn reduce the intensity of local electric fields around dendrites and lower the current density. Consequently, sodium ions are deposited more evenly, which helps inhibit dendrite growth. Our test results indicated stable cycling performance, with 250, 200, and 150 cycles achieved for deposition volumes of 0.25, 0.5, and 1.0 mAh cm-2, respectively, at a constant current density of 0.25 mA cm-2. By utilizing in situ optical cell analysis, we observed the effective suppression of dendrite growth. Furthermore, ex situ examination confirmed the absence of dendrite formation, even at a high deposition capacity of 5.0 mAh cm-2. These results underline the potential of using a 3D hierarchical porous structure to effectively improve the performance and longevity of sodium-metal batteries. | Lee, Sang Jun; Kang, Dongwoo; Hyeon, Dong Yeol; Kim, Dong Seok; Eom, Suyoon; Jeong, Su Hwan; Lee, Dong Park; Baek, Dawon; Ahn, Jou-Hyeon; Ryu, Gyeong Hee; Park, Kwi-Il; Moon, San; Kim, Joo-Hyung | Gyeongsang Natl Univ, Dept Mat Engn & Convergence Technol, Jinju 52828, South Korea; Samsung Electromech, Component Business Unit, High Capacitance MLCC Dev Grp, Pusan 46754, South Korea; Korea Adv Inst Sci & Technol, Dept Mat Sci & Engn, Daejeon 34141, South Korea; Korea Atom Energy Res Inst, LWR Fuel Technol Res Div, Daejeon 34057, South Korea; Gyeongsang Natl Univ, Sch Mat Sci & Engn, Jinju 52828, South Korea; Kyungpook Natl Univ, Sch Mat Sci & Engn, Daegu 41566, South Korea; Korea Res Inst Chem Technol, Energy Mat Res Ctr, Daejeon 34114, South Korea | Hyeon, Dong Yeol/HNR-5711-2023; Moon, San/NGR-6613-2025; Park, Kwiil/LKN-9445-2024 | 57204884419; 55754493400; 57209099464; 56032279100; 57898776700; 58198640200; 57886630200; 58482163600; 7403019494; 56026031000; 35280874200; 54796797100; 57865565300 | san82@krict.re.kr;kimjoohyung@gnu.ac.kr; | ENERGY STORAGE MATERIALS | ENERGY STORAGE MATER | 2405-8297 | 2405-8289 | 64 | SCIE | CHEMISTRY, PHYSICAL;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY | 2024 | 20.2 | 4.7 | 2.85 | 2025-04-16 | 11 | 11 | Dendrite -free; Free -standing; Ice-templating; In situ optical microscopy; Sodium metal anode | REDUCED GRAPHENE OXIDE; ION BATTERIES; PERFORMANCE | Dendrite-free; Free-standing; Ice-templating; In situ optical microscopy; Sodium metal anode | Cost effectiveness; Deposition; Electric fields; Electrodes; Graphene; Metal ions; Porosity; Secondary batteries; Battery performance; Dendrite growth; Dendrite-free; Free standings; Hierarchical porous structures; Ice templating; In situ optical microscopy; Metal anodes; Microscopic structures; Sodium metal anode; Sodium | English | 2024 | 2024-01 | 10.1016/j.ensm.2023.103047 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Correction | Stable sodium-metal batteries with a hierarchical structured electrode toward reversible confinement of Na dendrites(vol 64 ,103047,2024) | Lee, Sang Jun; Kang, Dongwoo; Hyeon, Dong Yeol; Kim, Dong Seok; Eom, Suyoon; Jeong, Su Hwan; Lee, Dong Park; Baek, Dawon; Ahn, Jou-Hyeon; Ryu, Gyeong Hee; Park, Kwi-Il; Moon, San; Kim, Joo-Hyung | Gyeongsang Natl Univ, Dept Mat Engn & Convergence Technol, Jinju 52828, South Korea; Samsung Electromech, Component Business Unit, High Capacitance MLCC Dev Grp, Pusan 46754, South Korea; Korea Adv Inst Sci & Technol, Dept Mat Sci & Engn, Daejeon 34141, South Korea; Korea Atom Energy Res Inst, LWR Fuel Technol Res Div, Daejeon 34057, South Korea; Gyeongsang Natl Univ, Sch Mat Sci & Engn, Jinju 52828, South Korea; Kyungpook Natl Univ, Sch Mat Sci & Engn, Daegu 41566, South Korea; Korea Res Inst Chem Technol, Energy Mat Res Ctr, Daejeon 34114, South Korea | Hyeon, Dong Yeol/HNR-5711-2023; Moon, San/NGR-6613-2025; Park, Kwiil/LKN-9445-2024 | 57204884419; 55754493400; 57209099464; 56032279100; 57898776700; 58198640200; 57886630200; 58482163600; 7403019494; 56026031000; 35280874200; 54796797100; 57865565300 | san82@krict.re.kr;kimjoohyung@gnu.ac.kr; | ENERGY STORAGE MATERIALS | ENERGY STORAGE MATER | 2405-8297 | 2405-8289 | 65 | SCIE | CHEMISTRY, PHYSICAL;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY | 2024 | 20.2 | 4.7 | 0 | 2025-05-07 | 0 | 1 | English | 2024 | 2024-02 | 10.1016/j.ensm.2023.103104 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||||
| ○ | ○ | Article | Thermal recycling analysis in regenerative cooling channels based on liquid rocket engine cycles | For rocket cycles involving electric pumps, gas generators, expanders, and staged combustion, a thermal recycling method is proposed to provide a more realistic simulation of regenerative cooling systems in liquid rocket engines. This method simulates a real situation where the outlet of the cooling channel is thermally recycled through the turbine or preburner to the inlet of the combustion chamber. Supercritical fluid properties are determined using the extended Redlich-Kwong (RK)-Peng-Robinson (PR) real-fluid equation of state. The axisymmetric reacting flows of a thrust chamber with regenerative cooling channels are simulated using the flamelet-based lookup table. To account for the multi-injector effect in the two-dimensional axisymmetric simulation, a non-uniform velocity distribution is implemented, utilizing exponential distributions of each injector's mass flow rate. For the hot gas temperature, coolant temperature, and cooling mass flowrate, the thermal recycling method is comparatively analyzed with the thermal decoupling method. The regeneration effect of the heated fuel is explored by evaluating the inflow energy, reaction energy, wall heat transfer, and the exit kinetic energy conversion. The thermal recycling method is developed for regeneratively cooled rocket engines with the expander, gas generator, staged combustion, and electric-pump cycles. Through this numerical procedure, the thermal recycling method is successfully applied to a liquid oxygen/methane engine and NASA's Crew Exploration Vehicle nozzle with two types of cooling. Based on the results of the four types of rocket cycles, it is confirmed that the specific impulse increases by 1.5-2% due to the regenerative heat effect. | Jeon, Tae Jun; Park, Tae Seon | Kyungpook Natl Univ, Sch Mech Engn, 80 Daehak Ro, Daegu 41566, South Korea | 59243229500; 7401801892 | tsparkjp@knu.ac.kr; | APPLIED THERMAL ENGINEERING | APPL THERM ENG | 1359-4311 | 1873-5606 | 256 | SCIE | ENERGY & FUELS;ENGINEERING, MECHANICAL;MECHANICS;THERMODYNAMICS | 2024 | 6.9 | 4.7 | 0.65 | 2025-05-07 | 2 | 2 | Regenerative cooling; Thermal resistance method; Flamelet analysis; Liquid rocket engine cycle; Regeneration heat; Thermal recycling method | HEAT-TRANSFER; NUMERICAL-SIMULATION; THRUST CHAMBER; COMBUSTION; DESIGN | Flamelet analysis; Liquid rocket engine cycle; Regeneration heat; Regenerative cooling; Thermal recycling method; Thermal resistance method | Cooling; Effluent treatment; Equations of state; Gas generators; Heat resistance; Kinetic energy; Kinetics; Liquefied gases; NASA; Recycling; Rockets; Supercritical fluids; Flamelet analysis; Liquid rocket engine cycle; Liquid rocket engines; Recycling methods; Regeneration heat; Regenerative cooling; Regenerative cooling channel; Thermal recycling; Thermal recycling method; Thermal resistance method; Numerical methods | English | 2024 | 2024-11-01 | 10.1016/j.applthermaleng.2024.124095 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Unraveling the structure, chemical composition, and conserved signaling in leech teeth | Unlike vertebrates, the number of toothed taxa in invertebrates is very few, with leeches being the only tooth-bearing organisms in the phylum Annelida. Copious studies have been conducted regarding vertebrate teeth; however, studies regarding the structure and function of invertebrate teeth are limited. In this study, the tooth structure of leeches, specifically Hirudo nipponia and Haemadipsa rjukjuana, was revealed, which showed sharp and pointed teeth along the apex of three jaws. Understanding conserved signaling regulations among analogous organs is crucial for uncovering the underlying mechanisms during organogenesis. Therefore, to shed light on the evolutionary perspective of odontogenesis to some extent, we conducted de novo transcriptome analyses using embryonic mouse tooth germs, Hirudo teeth, and Helobdella proboscises to identify conserved signaling molecules involved in tooth development. The selection criteria were particularly based on the presence of tooth-related genes in mice, Hirudo teeth, and Helobdella proboscis, wherein 4113 genes were commonly expressed in all three specimens. Furthermore, the chemical nature of leech teeth was also examined via TEM-EDS to compare the chemical composition with vertebrate teeth. The examination of tissue-specific genetic information and chemical nature between leeches and mice revealed chemical similarities between leech and mice teeth, as well as conserved signaling molecules involved in tooth formation, including Ptpro, Prickle2, and Wnt16. Based on our findings, we propose that leech teeth express signaling molecules conserved in mice and these conserved tooth-specific signaling for dental hard tissue formation in mice would corresponds to the structural formation of the toothed jaw in leeches. | Aryal, Yam Prasad; Neupane, Sanjiv; Kwak, Hee-Jin; An, Chang-Hyeon; Sohn, Wern-Joo; Yamamoto, Hitoshi; Kwon, Tae-Yub; Min, Bong-Ki; Kim, Jae-Young; Cho, Sung-Jin | Chungbuk Natl Univ, Coll Nat Sci, Dept Biol Sci & Biotechnol, Cheongju 28644, Chungbuk, South Korea; SUNY Stony Brook, Dept Biochem & Cell Biol, Stony Brook, NY USA; Kyungpook Natl Univ, Sch Dent, Dept Oral & Maxillofacial Radiol, Daegu, South Korea; Daegu Haany Univ, Premajor Cosmet & Pharmaceut, Gyongsan, South Korea; Tokyo Dent Coll, Dept Histol & Dev Biol, Tokyo, Japan; Kyungpook Natl Univ, Sch Dent, Dept Dent Biomat, Daegu, South Korea; Yeungnam Univ, Ctr Res Facil, Gyongsan 712749, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Biochem, 177 Dalgubeol daero, Daegu 41940, South Korea | Kim, Ji-Youn/A-5779-2017; Neupane, Sanjiv/I-3470-2018; Kwak, Hee-Jin/KIJ-6769-2024 | 57202611163; 56183800400; 57204325089; 17134437600; 44161404800; 55725330600; 7202206084; 57211058922; 56812734700; 58879172200 | bkmin@ynu.ac.kr;jykim91@knu.ac.kr;sjchobio@chungbuk.ac.kr; | ANIMAL CELLS AND SYSTEMS | ANIM CELLS SYST | 1976-8354 | 2151-2485 | 28 | 1 | SCIE | CELL BIOLOGY;ZOOLOGY | 2024 | 3.2 | 4.7 | 0 | 2025-04-16 | 1 | 1 | Leech; teeth; transcriptome analysis; conserved signaling; chemical nature | CELL POLARITY; EVOLUTION; ENAMEL; LOCALIZATION; GENERATION; PRICKLE2; TISSUES; GENE | chemical nature; conserved signaling; Leech; teeth; transcriptome analysis | English | 2024 | 2024-12-31 | 10.1080/19768354.2024.2350736 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Preservation and reactivation strategies for quorum quenching media to combat membrane biofouling | Microbial quorum quenching (QQ), which addresses biofouling resistant to physical and chemical methods, presents a compelling solution. Enhancements in sustainability are imperative to ensure its long-term stability. This study explores QQ media preservation for extended use. Three media types were tested over 150 days: fresh BH4 cells, preserved/reactivated BH4 cells, and BH4 cell extracts. Initial QQ activities ranged in the appropriate levels from 1.08 to 1.24 h-1. Preservation in 50 mM Tris-HCl at 4 degrees C showed that media with whole cells retained approximately 60 % activity after 60 days, unlike cell extract media, which lost all activity. However, the dehydration and reactivation of BH4 cell media fully recovered the initial QQ activity while maintaining it for 150 days. In MBR tests, reactivated QQ media performed as effectively as those prepared with freshly cultured BH4 cells, delaying membrane fouling by 2-fold. Revitalizing QQ media in combination with chlorine-based chemically enhanced backwashing (CEB) further delayed fouling by 2.5 times compared to CEB alone. Reactivated QQ media retained robust activity even after prolonged MBR use. This study showcases the effectiveness of dehydration and reactivation techniques for preserving QQ media, ensuring its reliable long-term storage and utilization. However, further enhancements are necessary to optimize cell viability. | Iqbal, Tahir; Park, Hyeona; Shah, Syed Salman Ali; Kim, Jinwoo; Mameda, Naresh; Lee, Kibaek; Choo, Kwang-Ho | Kyungpook Natl Univ, Sch Architectural Civil Environm & Energy Engn, 80 Daehak Ro, Daegu 41566, South Korea; Kyungpook Natl Univ, Adv Inst Water Ind, 80 Daehak Ro, Daegu 41566, South Korea; Beijing Normal Univ, Adv Inst Nat Sci, Ctr Water Res, Zhuhai 519087, Peoples R China; Koneru Lakshmaiah Educ Fdn, Dept Chem, Guntur 522502, Andhra Pradesh, India; Chonnam Natl Univ, Dept Biotechnol & Bioengn, 77 Yongbong Ro, Gwangju 61186, South Korea; Kyungpook Natl Univ, Dept Environm Engn, 80 Daehak Ro, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Water & IT Engn, 80 Daehak Ro, Daegu 41566, South Korea | ; Shah, Syed Salman Ali/JCE-1663-2023; Mameda, Dr. Naresh/AAV-2711-2020; Choo, Kwang-Ho/A-3456-2016; Mameda, Naresh/AAV-2711-2020 | 57202130500; 57213039681; 57215722996; 57901150400; 57192214360; 55845961700; 7102083272 | chookh@knu.ac.kr; | JOURNAL OF MEMBRANE SCIENCE | J MEMBRANE SCI | 0376-7388 | 1873-3123 | 703 | SCIE | ENGINEERING, CHEMICAL;POLYMER SCIENCE | 2024 | 9 | 4.8 | 0.93 | 2025-05-07 | 3 | 3 | Media preservation; Media reactivation; Membrane bioreactor; Membrane fouling; Quorum quenching | ACTIVATED-SLUDGE; BACTERIA; BIOREACTOR; MBR; PARADIGM; SMBR | Media preservation; Media reactivation; Membrane bioreactor; Membrane fouling; Quorum quenching | Activation; Cells; Cytology; Dehydration; Fouling; Media; Membranes; Quenching; Biofouling; Cells; Cytology; Dehydration; Membrane fouling; Membranes; Quenching; cell extract; chlorine; Back washing; Cell extracts; Chemical method; Medium preservation; Medium reactivation; Membrane biofouling; Membrane bioreactor; Physical methods; Quenching media; Quorum quenching; Article; biofouling; cell viability; confocal laser scanning microscopy; controlled study; cytolysis; environmental temperature; preservation; quorum quenching; whole cell; Bioreactors | English | 2024 | 2024-06 | 10.1016/j.memsci.2024.122856 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Article | Solvent-resistant crosslinked polybenzimidazole membrane for use in enhanced molecular separation | In molecular separation using membranes, enhanced parameters, such as an increased flux and selectivity, are required for efficiency. Additionally, in molecular separation using solvents, solvent resistance is critical in preventing solvent-induced damage. However, most membranes lack resistances to specific harsh solvents, and simultaneously enhancing solvent flux and selectivity performance, which exhibit a trade-off relationship, is challenging. In this study, a high-performance solvent-resistant polybenzimidazole (PBI) membrane is fabricated via chemical crosslinking with divinyl sulfone (DVS). The membrane consists of porous finger-like support and dense skin layers, and the uniform DVS crosslinking of the PBI membrane is confirmed via chemical analysis. The DVS-crosslinked PBI membrane exhibits a superior solvent stability and separation performance, with an ethanol permeance and molecular weight cut-off of 5.88 L m−2 h−1 bar−1 and 483 g mol−1, respectively. These values represent an enhanced permeance and rejection performance compared to those of the pristine membrane. The DVS-crosslinked PBI membrane also displays a long-term stability in mepenzolate bromide separation over 72 h. © 2024 Elsevier B.V. | Shin, Sung Ju; Park, You-In; Park, Hosik; You, Jae Bem; Kim, Daehun; Bae, Sun Ho; Kwon, Sei; Yoo, Youngmin | Green Carbon Research Center, Chemical Process Division, Korea Research Institute of Chemical Technology (KRICT), Daejeon, 34114, South Korea; Green Carbon Research Center, Chemical Process Division, Korea Research Institute of Chemical Technology (KRICT), Daejeon, 34114, South Korea; Green Carbon Research Center, Chemical Process Division, Korea Research Institute of Chemical Technology (KRICT), Daejeon, 34114, South Korea, Department of Advanced Materials and Chemical Engineering, University of Science & Technology (UST), Daejeon, 34113, South Korea; Department of Chemical Engineering, Kyungpook National University (KNU), Daegu, 41566, South Korea, Graduate School of Energy Convergence and Climate Change, Kyungpook National University (KNU), Daegu, 41566, South Korea; Green Carbon Research Center, Chemical Process Division, Korea Research Institute of Chemical Technology (KRICT), Daejeon, 34114, South Korea, Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, South Korea; Green Carbon Research Center, Chemical Process Division, Korea Research Institute of Chemical Technology (KRICT), Daejeon, 34114, South Korea, Department of Chemical Engineering, Kyungpook National University (KNU), Daegu, 41566, South Korea; Green Carbon Research Center, Chemical Process Division, Korea Research Institute of Chemical Technology (KRICT), Daejeon, 34114, South Korea; Green Carbon Research Center, Chemical Process Division, Korea Research Institute of Chemical Technology (KRICT), Daejeon, 34114, South Korea | 57194010656; 7405372117; 16835102000; 55619455300; 57222872078; 58475271100; 57471391100; 55642500700 | ymyoo@krict.re.kr; | Journal of Membrane Science | J MEMBRANE SCI | 0376-7388 | 1873-3123 | 695 | SCIE | ENGINEERING, CHEMICAL;POLYMER SCIENCE | 2024 | 9 | 4.8 | 2.8 | 2025-05-07 | 11 | Divinyl sulfone; Membrane separation; Polybenzimidazole; Solvent-resistant membrane; Surface energy | English | Final | 2024 | 10.1016/j.memsci.2024.122463 | 바로가기 | 바로가기 | 바로가기 | |||||||||
| ○ | ○ | Article | Targeting YAP Activity and Glutamine Metabolism Cooperatively Suppresses Tumor Progression by Preventing Extracellular Matrix Accumulation | Cancer cells use multiple mechanisms to evade the effects of glutamine metabolism inhibitors. The pathways that govern responses to alterations in glutamine availability within the tumor may represent therapeutic targets for combinatorial strategies with these inhibitors. Here, we showed that targeting glutamine utilization stimulated Yes-associated protein (YAP) signaling in cancer cells by reducing cyclic adenosine monophosphate/protein kinase A (PKA)-dependent phosphorylation of large tumor suppressor (LATS). Elevated YAP activation induced extracellular matrix (ECM) deposition by increasing the secretion of connective tissue growth factor that promoted the production of fibronectin and collagen by surrounding fibroblasts. Consequently, inhibiting YAP synergized with inhibition of glutamine utilization to effectively suppress tumor growth in vivo, along with a concurrent decrease in ECM deposition. Blocking ECM remodeling also augmented the tumor suppressive effects of the glutamine utilization inhibitor. Collectively, these data reveal mechanisms by which targeting glutamine utilization increases ECM accumulation and identify potential strategies to reduce ECM levels and increase the efficacy of glutamine metabolism inhibitors.Significance: Blocking glutamine utilization activates YAP to promote ECM deposition by fibroblasts, highlighting the potential of YAP inhibitors and antifibrotic strategies as promising approaches for effective combination metabolic therapies in cancer. | Park, Mihyang; Jin, Jonghwa; An, Da Young; Kim, Dong-Ho; Lee, Jaebon; Yun, Jae Won; Hwang, Ilseon; Park, Jae Seok; Kim, Mi Kyung; Lee, You Mie; Byun, Jun-Kyu; Choi, Yeon-Kyung; Park, Keun-Gyu | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Res Inst Aging & Metab, Daegu, South Korea; Kyungpook Natl Univ, Dept Biomed Sci, Daegu, South Korea; Vet Med Res Inst, Vet Hlth Serv Med Ctr, Seoul, South Korea; Keimyung Univ, Dept Pathol, Sch Med, Daegu, South Korea; Keimyung Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Coll Pharm, Vessel Organ Interact Res Ctr VOICE MRC, Daegu, South Korea; Kyungpook Natl Univ, Inst Pharmaceut Sci, Coll Pharm, Daegu 41566, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Internal Med, Daegu, South Korea | ; Kim, Ee-Kyung/AAA-1068-2022; Yun, Jaewon/AAF-7135-2019; Lee, Kyung-Soo/C-9016-2011 | 57208338147; 57223246243; 59367329000; 57986980100; 57208329586; 55454111800; 14625308400; 8866846500; 59124316400; 8230508600; 57190427423; 35335932600; 57202558343 | kpark@knu.ac.kr;ykchoi@knu.ac.kr;jkbyun@knu.ac.kr; | CANCER RESEARCH | CANCER RES | 0008-5472 | 1538-7445 | 84 | 20 | SCIE | ONCOLOGY | 2024 | 16.6 | 4.8 | 1.4 | 2025-05-07 | 4 | 4 | HIPPO PATHWAY; INHIBITION; CANCER; CHEMOTHERAPY; ACTIVATION; DELIVERY; THERAPY; GROWTH | Adaptor Proteins, Signal Transducing; Animals; Cell Line, Tumor; Cell Proliferation; Disease Progression; Extracellular Matrix; Female; Fibroblasts; Glutamine; Humans; Mice; Mice, Nude; Neoplasms; Phosphorylation; Signal Transduction; Transcription Factors; Xenograft Model Antitumor Assays; YAP-Signaling Proteins; 3 aminopropionitrile; acetazolamide; caspase 3; collagen type 1; connective tissue growth factor; cyclic AMP; cyclic AMP dependent protein kinase; fibronectin; glutamine; granzyme B; immunoglobulin G; oligomycin; small interfering RNA; verteporfin; YAP signaling protein; glutamine; signal transducing adaptor protein; transcription factor; YAP signaling protein; YAP1 protein, human; animal cell; animal experiment; animal model; antineoplastic activity; Article; cell infiltration; cell viability; controlled study; enzyme activity; enzyme linked immunosorbent assay; extracellular matrix; Glutamine Metabolism; human; human cell; immunofluorescence assay; immunohistochemistry; male; metabolism; mouse; nonhuman; oxidative phosphorylation; oxygen consumption; protein expression; protein phosphorylation; reverse transcription polymerase chain reaction; RNA isolation; tumor growth; tumor microenvironment; tumor volume; Western blotting; animal; cell proliferation; disease exacerbation; drug effect; drug screening; drug therapy; female; fibroblast; metabolism; neoplasm; nude mouse; pathology; phosphorylation; signal transduction; tumor cell line | English | 2024 | 2024-10-15 | 10.1158/0008-5472.can-23-3933 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | TPACK expression patterns in preservice teachers' design of innovative physics teaching and learning materials | Background TPACK is a widely used framework for assessing teachers' competence in integrating technology in education. However, previous studies have shown varying interpretations of the relationship between TPACK elements. Qualitative studies that assess the manifestations of TPACK by examining the practices of pre-service teachers are rare. Objectives This study investigates technology integration in innovative physics teaching and learning materials designed by pre-service teachers and the manifestation of technological pedagogical content knowledge (TPACK) in empirical cases. Methods We qualitatively extracted the components of PCK, TPK, and TCK from the innovative physics teaching and learning materials developed by 22 pre-service teachers in their fourth year at a teachers' college in South Korea. We scored them based on the new evaluation criteria established in this study. Results and Conclusions Based on the materials, we identified three types of technology integration: Learning Materials Providing, Learning Activity Providing, and Virtual Experiments Creating. This study identifies teachers' level of TK and integrates it with TPACK expression. Results confirm the connection between TK and TCK and show that a strong PCK can serve as a basis for TPK. The TPACK expression pattern can help achieve balanced development of TPACK in teacher education. | Kim, Hyojoon; Song, Jinwoong; Ha, Sangwoo | Seoul Natl Univ, Dept Phys Educ, Seoul, South Korea; Korea Inst Curriculum & Evaluat, Jincheon, South Korea; Kyungpook Natl Univ, Dept Phys Educ, Daegu, South Korea; Kyungpook Natl Univ, Sci Educ Res Inst, Deagu, South Korea; Kyungpook Natl Univ, Dept Phys Educ, 80 Daehakro, Daegu 41566, South Korea | Song, Jinwoong/AAM-9633-2020 | 57211120002; 55500863500; 55215468100 | hswgcb@knu.ac.kr; | JOURNAL OF COMPUTER ASSISTED LEARNING | J COMPUT ASSIST LEAR | 0266-4909 | 1365-2729 | 40 | 4 | SSCI | EDUCATION & EDUCATIONAL RESEARCH | 2024 | 4.6 | 4.8 | 0 | 2025-05-07 | 0 | 0 | 21st century abilities; applications in subject areas; teacher professional development; teaching/learning strategies | PEDAGOGICAL CONTENT KNOWLEDGE; TECHNOLOGY; INTEGRATION; FRAMEWORK; EDUCATION; MODEL | 21st century abilities; applications in subject areas; teacher professional development; teaching/learning strategies | English | 2024 | 2024-08 | 10.1111/jcal.12965 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Advanced carbo-catalytic degradation of antibiotics using conductive polymer-seaweed biochar composite: Exploring N/S functionalization and non-radical dynamics | Polyaniline (PANI) and Saccharina Japanica seaweed (kelp) biochar (KBC) composites were synthesized in-situ through polymerization. This study presents a novel approach to the degradation of sulfamethoxazole (SMX), a prevalent antibiotic, using a PANI-KBC composite to activate peroxymonosulfate (PMS). Extensive characterizations of the PANI-KBC composite were conducted, resulting in successful synthesis, uniform distribution of PANI on the biochar surface, and the multifunctional role of PANI-KBC in SMX degradation. A removal efficiency of 97.24% for SMX (10 mg L-1) was attained in 60 min with PANI-KBC (0.1 g L-1) and PMS (1.0 mM) at pH 5.2, with PANI-KBC showing effectiveness (>92%) across a pH range of 3.0-9.0. In the degradation of SMX, both radical (SO4 center dot- and (OH)-O-center dot) and non-radical (O-1(2) and electron transfer) pathways are involved. The reaction processes are critically influenced by the roles of SO4 center dot-, O-1(2) and electron transfer mechanisms. It was suggested that pyrrolic N, oxidized sulfur (-C-SO2-C-), structural defects, and O-CO were implicated in the production of O-1(2) and electron transfer processes, respectively, and a portion of O-1(2) originated from the conversion of O-2(center dot-). The study evaluated by-product toxicity, composite reusability, and stability, confirming its practical potential for sustainable groundwater remediation. | Al Masud, Md Abdullah; Shin, Won Sik | Kyungpook Natl Univ, Sch Architecture Civil Environm & Energy Engn, Daegu 41566, South Korea | ; Masud, Md Abdullah Al/JEF-1055-2023 | 57542255300; 23019870800 | wshin@knu.ac.kr; | JOURNAL OF HAZARDOUS MATERIALS | J HAZARD MATER | 0304-3894 | 1873-3336 | 478 | SCIE | ENVIRONMENTAL SCIENCES;ENGINEERING, ENVIRONMENTAL | 2024 | 11.3 | 4.9 | 1.43 | 2025-05-07 | 8 | 7 | Antibiotic toxicity; Polyaniline composite; PMS activation; Seaweed biochar; Surface functionalities | OXIDATION; SULFAMETHOXAZOLE; POLYANILINE; REMOVAL; MECHANISMS; KINETICS; NITROGEN | Antibiotic toxicity; PMS activation; Polyaniline composite; Seaweed biochar; Surface functionalities | Aniline Compounds; Anti-Bacterial Agents; Catalysis; Charcoal; Peroxides; Seaweed; Sulfamethoxazole; Water Pollutants, Chemical; Electron transitions; Free radical reactions; Graphene; Groundwater; Reusability; Seaweed; Toxicity; antibiotic agent; carbon; charcoal; ground water; hydroxide; nitrogen; oxygen; polyaniline; polymer; radical; sulfamethoxazole; sulfate; sulfur; aniline derivative; antiinfective agent; peroxide; peroxymonosulfate; polyaniline; Antibiotic toxicity; Biochar; Catalytic degradation; Conductive Polymer; Peroxymonosulfate; Peroxymonosulfate activations; Polyaniline composites; Seaweed biochar; Sulfamethoxazole; Surface functionalities; antibiotics; biochar; byproduct; composite; electron; environmental degradation; groundwater; polymerization; seaweed; adsorption; Article; catalysis; catalyst; catalytic efficiency; controlled study; cross linking; crystal structure; current density; decomposition; degradation; electron diffraction; electron spin resonance; electron transport; environmental impact; equilibrium constant; evaporation; first order rate constant; germination; impedance spectroscopy; isotherm; morphology; oxidation; pH; physical chemistry; polymerization; pore volume; Raman spectrometry; reaction analysis; seaweed; species distribution; surface area; surface property; synthesis; total organic carbon; X ray photoemission spectroscopy; catalysis; chemistry; metabolism; water pollutant; Antibiotics | English | 2024 | 2024-10-05 | 10.1016/j.jhazmat.2024.135449 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Center of Pressure- and Machine Learning-based Gait Score and Clinical Risk Factors for Predicting Functional Outcome in Acute Ischemic Stroke | Objectives: To investigate whether machine learning (ML)-based center of pressure (COP) analysis for gait assessment, when used in conjunction with clinical information, offers additive benefits in predicting functional outcomes in patients with acute ischemic stroke. Design: A prospective, single-center cohort study. Setting: A tertiary hospital setting. Participants: A total of 185 patients with acute ischemic stroke, capable of walking 10 m with or without a gait aid by day 7 postadmission. From these patients, 10,804 pairs of consecutive footfalls were included for analysis. Interventions: Not applicable. Main Outcome Measures: The dependent variable was a 3-month poor functional outcome, defined as modified Rankin scale score >= 2. For independent variables, 65 clinical variables including demographics, anthropometrics, comorbidities, laboratory data, questionnaires, and drug history were included. Gait function was evaluated using a pressure-sensitive mat. Time-series COP data were parameterized into spatial and temporal variables and analyzed with logistic regression and 2 ML models (light gradient-boosting machine and multilayer perceptron [MLP]). We derived GAIT-AI output scores from the best-performing model analyzed COP data and constructed multivariable logistic regression models using clinical variables and the GAIT scores. Results: Among the included patients, 70 (37.8%) experienced unfavorable outcomes. The MLP model demonstrated the highest predictive performance with an area under the receiver operating characteristic curve (AUROC) of 0.799. Multivariable logistic regression identified age, initial National Institutes of Health Stroke Scale, and initial Fall Efficacy Scale-International as associated factors with unfavorable outcomes. The combined multivariable logistic regression incorporating COP-derived output scores improved the AUROC to 0.812. Conclusions: Gait function, assessed through COP analysis, serves as a significant predictor of functional outcome in patients with acute ischemic stroke. ML-based COP analysis, when combined with clinical data, enhances the prediction of poor functional outcomes. Archives of Physical Medicine and Rehabilitation 2024;105:2277-85 (c) 2024 by the American Congress of Rehabilitation Medicine. | Jeon, Eun-Tae; Lee, Sang-hun; Eun, Mi-Yeon; Jung, Jin-Man | Korea Univ, Coll Med, Ansan Hosp, Dept Neurol, Ansan, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Neurol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Neurol, Daegu, South Korea; Korea Univ, Grad Sch, Dept Neurol, Seoul, South Korea; Korea Univ, Zebrafish Translat Med Res Ctr, Ansan, South Korea | Eun, Mi-Yeon/AAV-2877-2021; Jeon, Eun-Tae/AEI-9225-2022; Lee, Sang-Hun/W-3000-2019; Jung, Jin-Man/LJL-8037-2024 | 57195325591; 57191613091; 36463396500; 15755814800 | jinmanjung@gmail.com;dr.jinmanjung@gmail.com; | ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION | ARCH PHYS MED REHAB | 0003-9993 | 1532-821X | 105 | 12 | SCIE | REHABILITATION;SPORT SCIENCES | 2024 | 3.7 | 4.9 | 0 | 2025-05-07 | 1 | 1 | Gait; Ischemic stroke; Machine learning; Outcome; Prediction model; Rehabilitation | MORTALITY; FALLS | Gait; Ischemic stroke; Machine learning; Outcome; Prediction model; Rehabilitation | Aged; Aged, 80 and over; Female; Gait; Gait Analysis; Gait Disorders, Neurologic; Humans; Ischemic Stroke; Machine Learning; Male; Middle Aged; Pressure; Prospective Studies; Recovery of Function; Risk Factors; Stroke Rehabilitation; acute ischemic stroke; adult; aged; anthropometry; Article; Barthel index; cohort analysis; cross validation; demographics; Falls Efficacy Scale; feature selection; female; functional status; gait; human; machine learning; major clinical study; male; multilayer perceptron; National Institutes of Health Stroke Scale; outcome assessment; prospective study; Rankin scale; risk; treatment outcome; walking; convalescence; gait; ischemic stroke; middle aged; neurologic gait disorder; pathophysiology; physiology; pressure; procedures; rehabilitation; risk factor; stroke rehabilitation; very elderly | English | 2024 | 2024-12 | 10.1016/j.apmr.2024.08.006 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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