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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Effect of hemicellulose molecular structure on wettability and surface adhesion to urea-formaldehyde resin adhesives | This study examined the effect of hemicellulose molecular structure on wettability and surface adhesion to urea-formaldehyde resin adhesives to better understand the complex adhesion process of wood biopolymers. Molecular structure of two hemicelluloses, such as arabinogalactan and xylan, was characterized using Fourier transform infrared, one-dimensional, and two-dimensional nuclear magnetic resonances. As a result, arabinogalactan had a hyperbranched structure, whereas xylan was more linear, which caused a distinctive morphology in their films, with the latter having a rougher surface. Further, the surface adhesion between hemicellulose and UF resins with various formaldehyde to urea molar ratios (1.0 and 1.6) was measured. The adhesion force and work of adhesion of arabinogalactan with different UF resins were found to be greater than those of xylan due to the former film's higher surface free energy, more exposed OH groups, and smoother surface. In addition, 1.6 UF resins exhibited greater adhesion than 1.0 UF resins, regardless of the hemicellulose type, demonstrating that dispersion force was dominant in their molecular interactions. | Wibowo, Eko Setio; Park, Byung-Dae | Kyungpook Natl Univ, Dept Wood & Paper Sci, Daegu 41566, South Korea | ; Park, Byung-Dae/ABB-1934-2020; Wibowo, Eko/AAL-5888-2021 | 57214910272; 7402834820 | byungdae@knu.ac.kr; | WOOD SCIENCE AND TECHNOLOGY | WOOD SCI TECHNOL | 0043-7719 | 1432-5225 | 56 | 4 | SCIE | FORESTRY;MATERIALS SCIENCE, PAPER & WOOD | 2022 | 3.4 | 7.1 | 1.25 | 2025-06-25 | 11 | 14 | INFRARED-SPECTROSCOPY; XYLAN; ARABINOGALACTAN; CONTACT; FILMS; WOOD; BIOPOLYMERS; PENETRATION; EMISSION; SMOOTH | Adhesives; Cellulose; Formaldehyde; Free Energy; Metabolism; Molecular Structure; Adhesives; Biopolymers; Cellulose; Formaldehyde; Free energy; Metabolism; Molar ratio; Molecular structure; Morphology; Urea; Urea formaldehyde resins; Wetting; Adhesion forces; Arabinogalactan; Fourier transform infrared; Hyper-branched structures; Molar ratio; One-dimensional; Rough surfaces; Surface adhesion; Two-dimensional nuclear magnetic resonance; Urea-formaldehyde resin adhesives; Adhesion | English | 2022 | 2022-07 | 10.1007/s00226-022-01397-8 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Effects of molecular weight of urea-formaldehyde resins on wettability and adhesion at wood surface, interphase, and plywood | Various factors, such as molecular weight (MW), reactivity, wettability, surface roughness, surface adhesion, interphase adhesion, and cohesion of adhesives, affect the adhesion strength of urea-formaldehyde (UF) resins when bonding wood. This study was conducted to understand the MW effects of UF resins on wettability and adhesion at wood surface, interphase, and plywood. UF resins with two formaldehyde/urea (F/U) molar ratios (1.0 and 1.6) and three MW levels such as low-MW (L-MW), middle-MW (M-MW), and high-MW (H-MW) were evaluated for their wettability and adhesion. As the MW increases, the surface tension of 1.0 UF resins slightly increased, while that of 1.6 UF resins slightly decreased. The contact angle of UF resins on earlywood and latewood either from sapwood or heartwood (Radiata pine: Pinus radiata D. Don) before and after the extractive removal was dependent on the wood surface roughness rather than on the MWs of resins, showing a weak negative linear relationship with the surface roughness. The maximum surface adhesion force of 1.0 UF resins was greater at latewood than earlywood from sapwood before the extraction, but it decreased after the extractive removal. 1.0 UF resins showed the highest interphase adhesion at H-MW level, whereas 1.6 UF resins gave the strongest interphase adhesion at M-MW level although 1.6 UF resins had greater interphase adhesion than those of 1.0 UF resins for sapwood and heartwood. However, tensile shear strength of plywood did not proportionately relate to the wettability, surface adhesion, and interphase adhesion of UF resins. These results suggest that the MW, wettability, and surface adhesion of UF resins are indirectly related to interphase adhesion and adhesion strength in wood bonding. | Kim, Minjeong; Park, Byung-Dae | Kyungpook Natl Univ, Dept Wood & Paper Sci, Daegu 41566, South Korea | Park, Byung-Dae/ABB-1934-2020 | 57215818497; 7402834820 | byungdae@knu.ac.kr; | WOOD SCIENCE AND TECHNOLOGY | WOOD SCI TECHNOL | 0043-7719 | 1432-5225 | 56 | 6 | SCIE | FORESTRY;MATERIALS SCIENCE, PAPER & WOOD | 2022 | 3.4 | 7.1 | 0.87 | 2025-06-25 | 9 | 9 | CELLULAR-LEVEL DISTRIBUTIONS; MOLE RATIO; RADIAL PENETRATION; CONTACT ANGLES; HEARTWOOD; EXTRACTIVES; ROUGHNESS; PERFORMANCE; BEHAVIOR; SUBSTANCES | Adhesion; Adhesives; Contact Angle; Formaldehyde; Metabolism; Molecular Weight; Adhesion; Adhesives; Bond strength (materials); Contact angle; Formaldehyde; Metabolism; Molar ratio; Molecular weight; Plywood; Resins; Surface roughness; Urea; Wetting; Adhesion interphase; Earlywood; Interphase adhesion; Latewood; Molar ratio; Molecular weight effect; Roughness surfaces; Surface adhesion; Urea-formaldehyde resin; Wood surfaces; Urea formaldehyde resins | English | 2022 | 2022-11 | 10.1007/s00226-022-01420-y | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | GJA1 depletion causes ciliary defects by affecting Rab11 trafficking to the ciliary base | The gap junction complex functions as a transport channel across the membrane. Among gap junction subunits, gap junction protein alpha 1 (GJA1) is the most commonly expressed subunit. A recent study showed that GJA1 is necessary for the maintenance of motile cilia; however, the molecular mechanism and function of GJA1 in ciliogenesis remain unknown. Here, we examined the functions of GJA1 during ciliogenesis in human retinal pigment epithelium-1 and Xenopus laevis embryonic multiciliated-cells. GJA1 localizes to the motile ciliary axonemes or pericentriolar regions beneath the primary cilium. GJA1 depletion caused malformation of both the primary cilium and motile cilia. Further study revealed that GJA1 depletion affected several ciliary proteins such as BBS4, CP110, and Rab11 in the pericentriolar region and basal body. Interestingly, CP110 removal from the mother centriole was significantly reduced by GJA1 depletion. Importantly, Rab11, a key regulator during ciliogenesis, was immunoprecipitated with GJA1 and GJA1 knockdown caused the mislocalization of Rab11. These findings suggest that GJA1 regulates ciliogenesis by interacting with the Rab11-Rab8 ciliary trafficking pathway. | Jang, Dong Gil; Kwon, Keun Yeong; Kweon, Yeong Cheon; Kim, Byung-gyu; Myung, Kyungjae; Lee, Hyun-Shik; Park, Chan Young; Kwon, Taejoon; Park, Tae Joo | Ulsan Natl Inst Sci & Technol, Dept Biol Sci, Ulsan, South Korea; Inst Basic Sci, Ctr Genom Integr, Ulsan, South Korea; Kyungpook Natl Univ, Coll Nat Sci, KNU Ctr Nonlinear Dynam, Sch Life Sci,BK21 Plus KNU Creat Bio Res Grp,CMRI, Daegu, South Korea; Ulsan Natl Inst Sci & Technol, Dept Biomed Engn, Ulsan, South Korea | ; Park, Tae Joo/G-1460-2011; Kwon, Taejoon/S-3835-2016; Park, Chan Young/GPG-0558-2022 | 57204170015; 57204164804; 57202042840; 55797167500; 57045635100; 16316010200; 55728028500; 35484365800; 58254025900 | tkwon@unist.ac.kr;parktj@unist.ac.kr; | ELIFE | ELIFE | 2050-084X | 11 | SCIE | BIOLOGY | 2022 | 7.7 | 7.1 | 0.6 | 2025-06-25 | 4 | 6 | cilia; GJA1; Rab11; Mouse; Xenopus | GAP-JUNCTION PROTEIN; PRIMARY CILIUM; CELL-MIGRATION; CONNEXIN GENES; XENOPUS; MOUSE; LOCALIZATION; CYTOSKELETON; LATERALITY; MUTATIONS | Animals; Basal Bodies; Centrioles; Centrosome; Cilia; Connexin 43; Humans; Xenopus laevis; connexin 43; CRISPR associated endonuclease Cas9; gap junction protein; gap junction protein alpha 1; Rab11 protein; small interfering RNA; tubulin; unclassified drug; GJA1 protein, human; adult; Article; axoneme; cell isolation; ciliary motility; CRISPR-CAS9 system; female; gene editing; gene ontology; genetic transfection; hTERT-RPE1 cell line; image analysis; immunoblotting; immunocytochemistry; immunofluorescence; immunohistochemistry; immunoprecipitation; in situ hybridization; male; mass spectrometry; nonhuman; plasmid; primary cilium; protein expression; protein function; retinal pigment epithelium; Xenopus laevis; animal; centriole; centrosome; cilium; human; kinetosome; metabolism | English | 2022 | 2022-08-25 | 10.7554/elife.81016 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Irreversibility and hydrothermal analysis of the MWCNTs/GNPs-based nanofluids for electronics cooling applications of the pin-fin heat sinks: Multiphase Eulerian-Lagrangian modeling | Identifying optimal pin-fin configurations is essential to analyze the full potential of utilizing nanofluids in pin-fin heat sinks for electronics cooling applications. Therefore, the present study aimed to investigate the entropy generation and hydrothermal characteristics of water-based MWCNT (Multiwalled carbon nanotubes) and MWCNT/GNP (Multiwalled carbon nanotubes/graphene nanoplatelets) nanofluids in a heat sink equipped with fins of different configurations. The forced convection of the nanofluid was simulated through the multiphase Eulerian-Lagrangian model (discrete-phase model) by including the influence of slip mechanisms (Brownian motion, thermophoresis, Saffman lift and drag forces, pressure forces, virtual mass, and gravity) and the interphase nanolayering effect. Results showed that the performance of the MWCNT and MWCNT/GNP nanofluids was the highest in the triangular pin-fin heat sink, followed by rhombus and hydrofoil pin-fin heat sinks. The streamlined shape along with the large lateral and small stream-wise interspacing between the hydrofoil and rhombus fins hindered the effective coolant distribution across the heat sinks, thereby deteriorating their heat-dissipation capacity. However, the performance evaluation criteria results of the rhombus pin-fin heat sink outperformed the other pin-fin configurations due to the lower pressure drop. | Ambreen, Tehmina; Saleem, Arslan; Tanveer, Muhammad; Anirudh, K.; Shehzad, S. A.; Park, Cheol Woo | Kyungpook Natl Univ, Sch Mech Engn, 80 Daehakro, Bukgu Daegu 41566, South Korea; Pandit Deendayal Energy Univ, Sch Technol, Dept Mech Engn, Raisan 382426, Gandhinagar, India; COMSATS Univ Islamabad, Dept Math, Sahiwal 57000, Pakistan | ; Saleem, Arslan/ABA-5982-2021; Kulkarni, Anirudh/Q-1164-2019; Shehzad, Sabir/J-3885-2014; Tanveer, MuhammadShahbaz/LUY-0421-2024 | 57195420431; 57194776354; 23486949200; 57190669612; 42262831200; 7408416474 | chwoopark@knu.ac.kr; | CASE STUDIES IN THERMAL ENGINEERING | CASE STUD THERM ENG | 2214-157X | 31 | SCIE | THERMODYNAMICS | 2022 | 6.8 | 7.1 | 3.74 | 2025-06-25 | 32 | 37 | Hydrofoil pin-fin heat sink; Entropy generation; Hydrothermal performance; Multiwalled carbon nanotubes; Graphene nanoplatelets | THERMAL-CONDUCTIVITY; HYBRID NANOFLUID; PERFORMANCE; FLOW; MICRO; PARTICLES; SIMULATION; DISPERSION; CHANNEL; FLUID | Entropy generation; Graphene nanoplatelets; Hydrofoil pin-fin heat sink; Hydrothermal performance; Multiwalled carbon nanotubes | Brownian movement; Drag; Electronic cooling; Fins (heat exchange); Gravitation; Lagrange multipliers; Multiwalled carbon nanotubes (MWCN); Nanofluidics; Cooling applications; Electronics cooling; Entropy generation; Graphene nanoplatelets; Hydrofoil pin-fin heat sink; Hydrothermal performance; Multi-walled-carbon-nanotubes; Nanofluids; Performance; Pin fin heat sinks; Entropy | English | 2022 | 2022-03 | 10.1016/j.csite.2022.101806 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Numerical case study and modeling for spreading thermal resistance and effective thermal conductivity for flat heat pipe | Flat heat pipe, vapor chamber, thermal ground plane, and heat spreader have been emerging topics for various thermal applications such as electric battery packs and high-power computer chips. In this study, computational fluid dynamics is used to model the effective thermal conductivity of a vapor chamber and thermal ground plane. From various literature, simulation conditions are obtained for different flat heat pipe geometries. With the commercial code Fluent (Ansys Inc.), 4,800 cases have been used to examine the spreading thermal resistance tendencies for the different heat sink areas, heat source area, thickness, and heat transfer coefficient. In conclusion, the effective thermal conductivity increases when the thickness decreases or the heat sink area becomes greater with the same spreading thermal resistance value. In particular, the modified model of spreading thermal resistance is proposed for a better accuracy targeting various effective thermal conductivity, based on the original analytical model. A good agreement with a better accuracy is found between the model and the numerical results. This study will be able to provide the thermal system guideline for flat heat pipes. | Kim, Myeongjin; Lee, Kyun Ho; Han, Dong In; Moon, Joo Hyun | Kyungpook Natl Univ, Sch Convergence, Dept Hydrogen & Renewable Energy, Daegu, South Korea; Sejong Univ, Seoul, South Korea; Korea Aerosp Res Inst, Daejeon, South Korea | ; Moon, Joo/AAN-3395-2021 | 55541419000; 56518525900; 57225956657; 56388836900 | jhmoon9@sejong.ac.kr; | CASE STUDIES IN THERMAL ENGINEERING | CASE STUD THERM ENG | 2214-157X | 31 | SCIE | THERMODYNAMICS | 2022 | 6.8 | 7.1 | 1.87 | 2025-06-25 | 15 | 19 | Computational fluid dynamics (CFD); Effective thermal conductivity; Flat heat pipe; Spreading thermal resistance; Thermal system design | VAPOR CHAMBER; OPTIMIZATION; PERFORMANCE | Computational fluid dynamics (CFD); Effective thermal conductivity; Flat heat pipe; Spreading thermal resistance; Thermal system design | Heat pipes; Heat resistance; Heat sinks; Heat transfer; Thermal conductivity; Thermal management (electronics); Case-studies; Computational fluid dynamic; Effective thermal conductivity; Flat heat pipe; Ground heats; Ground planes; Spreading thermal resistance; Thermal; Thermal system design; Vapor chamber; Computational fluid dynamics | English | 2022 | 2022-03 | 10.1016/j.csite.2022.101803 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Article | Climate variability impacts on runoff projection under quantile mapping bias correction in the support CMIP6: An investigation in Lushi basin of China | In this study, we modelled the XAJ (Xin'anjiang) hydrologic model parameters for the Lushi basin of China, an important tributary of the Yellow River. Time series of daily precipitation, evaporation, and runoff data from 1976 to 1995 were used to calibrate the model, while the data from 1996 to 2000 were used for validation. Thereafter, the future climate variability was projected from 2021 to 2100 for 0.22° grids under CMIP6 CORDEX-East-Asia (Coordinated Regional Climate Downscaling Experiment-East-Asia) RCP2.6 and RCP8.5 climate scenarios. The non-parametric quantile mapping (QM) bias correction method was used to minimize the large differences between climate variability directly derived from the regional circulation model (RCM) and the historical observations, and the results were also compared with the baseline period (1976–2000). Overall, when compared to the baseline case, results showed a decline in the annual precipitation by 7.22 % and 5.01 %, while an increase was observed for the annual evaporation by 2.03 % and 3.58 % under RCP2.6 and RCP8.5 climate scenarios in the 21st century. Annual runoff projection by XAJ model indicate reduction, with 9.3 % and 31.2 % fall for short-term (2021–2040), 31.5 % and 41.2 % fall for mid-term (2051–2070) and 32.3 % and 77.4 % fall for long-term (2081–2100), respectively. The extreme streamflow projects increase during the dry period (November to June) with 76.5 m3/s and 84.6 m3/s under RCP2.6 and RCP8.5 compared to 45.6 m3/s from the baseline period. In contrast, there is a decrease during the wet period (July to October) by 390 m3/s and 237 m3/s compared to 405 m3/s in the baseline data of the same period. Such projections become more pronounced toward the end of the 21st century, and the reduction is likely to continue if future climate projections occur. The hydrological parameters can be applied to adjacent and similar landscape basins for disaster forecasting and early warning. The QM method is effective in bias correction. The findings can also be used for flood and drought mitigation planning and water resources management in the Yellow River Basin. © 2022 Elsevier B.V. | Xue, Peipei; Zhang, Chenguang; Wen, Zhang; Park, Eungyu; Jakada, Hamza | Hubei Key Laboratory of Yangtze Catchment Environmental Aquatic Science, School of Environmental Studies, China University of Geosciences, Hubei, Wuhan, 430074, China; Hubei Key Laboratory of Yangtze Catchment Environmental Aquatic Science, School of Environmental Studies, China University of Geosciences, Hubei, Wuhan, 430074, China; Hubei Key Laboratory of Yangtze Catchment Environmental Aquatic Science, School of Environmental Studies, China University of Geosciences, Hubei, Wuhan, 430074, China; Department of Geology, Kyungpook National University, Daegu, South Korea; Department of Civil Engineering, Baze University, Abuja, Nigeria | 57221745228; 57939623100; 15020088000; 23995577700; 57096062200 | wenz@cug.edu.cn; | Journal of Hydrology | J HYDROL | 0022-1694 | 1879-2707 | 614 | SCIE | ENGINEERING, CIVIL;GEOSCIENCES, MULTIDISCIPLINARY;WATER RESOURCES | 2022 | 6.4 | 7.2 | 2.4 | 2025-06-25 | 23 | Bias correction; Climate variability; Hydrological modelling; Regional circulation model (RCM); Runoff projection | China; Henan; Lushi Basin; Yellow River Basin; Climate models; Mapping; Runoff; % reductions; Bias correction; Climate scenarios; Climate variability; Hydrologic models; Hydrological models; Mapping bias; Regional circulation model; Regional circulation models; Runoff projections; climate effect; CMIP; numerical model; runoff; streamflow; Evaporation | English | Final | 2022 | 10.1016/j.jhydrol.2022.128550 | 바로가기 | 바로가기 | 바로가기 | ||||||||
| ○ | ○ | Article | Development of a data-driven ensemble regressor and its applicability for identifying contextual and collective outliers in groundwater level time-series data | In this study, a method to estimate the normal range of groundwater level time-series data was developed to identify outliers in terms of the global, contextual, and collective sense. To evaluate the normal range of groundwater level time-series data, the statistical characteristics of the data and the patterns of the precipitation time-series data were incorporated into the LSTM (Long Short-Term Memory)-based ensemble regressor (i.e., the LER model). Based on the LER model, multiple possible trends of the groundwater level were generated, and the general rules of outlier identification methods (i.e., sigma and Tukey's fences (TF) rules) were applied to the LER ensemble estimation result to finally define the range of the normal data. For outlier identification performance validation, the actual groundwater level acquired from three groundwater monitoring stations in South Korea (i. e., the Pohang-Gibuk (PG), Namwon-Dotong (ND), and Jeju-Sangyae (JS) monitoring wells) and the corresponding precipitation data acquired from the nearest weather stations were applied to the study. As the reference method for comparative performance validation, simple applications of the sigma and TF rules were used. For the monitoring data, the developed LER-based outlier identification method evaluates the range of the data that might be explained by the modelled influences of the interest (i.e., normal data range). The developed method showed an outlier identification performance of >70% in general while the performance of the sigma and TF rules was mostly <50%. In particular, as the method effectively estimated the seasonal trend and the variability of the groundwater level with consideration of the precipitation patterns and statistics on the groundwater level variation, it is superior for identifying the contextual or collective outliers compared to the simple sigma and TF rules. Through in-depth analysis, it can be concluded that the developed LER-based outlier identification method is effective for discriminating the abnormal data by considering the intrinsic statistical characteristics of the original data trend and the exogenous factors. In the aspect of the practical applicability, as the result can be automatically acquired based on real-time monitoring data, the developed method is expected to apply for more efficient maintenance of the monitoring devices by embedding the model as the management software into the monitoring network system. | Kim, Yuhan; Jeong, Jiho; Park, Heejeong; Kwon, Mijin; Cho, Chunhyung; Jeong, Jina | Kyungpook Natl Univ, Dept Geol, Daegu, South Korea; Korea Radioact Waste Agcy KORAD, Daejeon, South Korea | Kwon, Mijin/HTN-6246-2023 | 57226608853; 57218684286; 57226598607; 57195576048; 57220796131; 55488558800 | jeong.j@knu.ac.kr; | JOURNAL OF HYDROLOGY | J HYDROL | 0022-1694 | 1879-2707 | 612 | SCIE | ENGINEERING, CIVIL;GEOSCIENCES, MULTIDISCIPLINARY;WATER RESOURCES | 2022 | 6.4 | 7.2 | 0.52 | 2025-06-25 | 4 | 6 | Long short-term memory; Groundwater level fluctuation; Ensemble estimation; Normal data range; Contextual and collective outlier identification | PRECIPITATION; ISLAND | Contextual and collective outlier identification; Ensemble estimation; Groundwater level fluctuation; Long short-term memory; Normal data range | Cheju [Cheju (PRV/ISL)]; Korea; Namwon; North Cholla; North Kyongsang; Pohang; South Korea; South Korea; Brain; Groundwater; Monitoring; Time series; Contextual and collective outlier identification; Data ranges; Ensemble estimation; Ground water level; Groundwater level fluctuation; Identification method; Normal data range; Outlier identification; Statistical characteristics; Time-series data; groundwater; identification method; monitoring; software; time series; Long short-term memory | English | 2022 | 2022-09 | 10.1016/j.jhydrol.2022.128127 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Development of data-driven models for estimating the probability of high-concentration occurrence of naturally occurring radioactive materials in groundwater | High-concentration occurrence probability estimation models was developed to estimate 238U and 222Rn in groundwater using in-situ monitoring data (i.e., geological rock types, well depth, T, pH, Eh, EC, DO, and HCO3). The estimation models are based on a non-linear data-driven method to improve their effectiveness for applications in different estimation cases using various in-situ monitoring data. When developing the models, most sensitive in-situ monitoring data are selectively utilized to train the models, where various statistical and correlation analyses are applied to overcome challenges, including model overfitting during training, a highly nonlinear correlation between input and target variables, and poor training due to low-quality monitoring data. Based on statistical analysis results, all input variables, except for Eh and well depth, are used for developing the 238U and 222Rn estimation models, respectively. Actual data collected from groundwater quality monitoring networks of South Korea from 2007 to 2019 are used to validate the developed models. Although it is difficult to characterize 222Rn occurrence using the geochemical conditions of groundwater because the gaseous phase behavior of 222Rn highly depends on structural geology, the 222Rn estimation model achieves reasonable performance with more than 70% accuracy. In addition, compared to the 222Rn estimation model, the 238U estimation model achieves higher classification accuracy with approximately 80%. Consequently, we can confirm that the developed estimation models can be effectively used to estimate the probability of high-concentration risk of 238U and 222Rn in groundwater. Conclusively, the practical applicability of the developed models is wide, as the models have been developed using direct observable and real-time data. | Jeong, Jina; Choung, Sungwook; Jeong, Do Hwan; Kim, Moon Su; Kim, Hyun Gu; Kim, Jeongwoo | Kyungpook Natl Univ, Dept Geol, Daegu, South Korea; Korea Basic Sci Inst, Res Ctr Geochronol & Isotope Anal, Choengju, South Korea; Natl Inst Environm Res, Incheon, South Korea; Geogreen21 Co Ltd, Seoul, South Korea | 55488558800; 36436826400; 57388778400; 56122984400; 57388381600; 55862544200 | schoung@kbsi.re.kr;hyd009@korea.kr; | JOURNAL OF HYDROLOGY | J HYDROL | 0022-1694 | 1879-2707 | 605 | SCIE | ENGINEERING, CIVIL;GEOSCIENCES, MULTIDISCIPLINARY;WATER RESOURCES | 2022 | 6.4 | 7.2 | 0.31 | 2025-06-25 | 3 | 3 | Naturally Occuring Radioactive Materials; (NORMs); Groundwater; Sensitivity analysis; Data -driven model; In-situ Monitoring | RADON; URANIUM; THORIUM; GEOLOGY; WATER; RISK; MAP | Data-driven model; Groundwater; In-situ Monitoring; Naturally Occuring Radioactive Materials (NORMs); Sensitivity analysis | South Korea; Geology; Groundwater; Monitoring; Risk perception; Water quality; Data-driven model; Developed model; Estimation models; In-situ monitoring; Naturally occuring radioactive material; Naturally occuring radioactive materials; Naturally occurring radioactive materials; Occurrence probability; Probability estimation; Well depth; estimation method; groundwater; hydrological modeling; in situ measurement; probability; radioactive waste; sensitivity analysis; Sensitivity analysis | English | 2022 | 2022-02 | 10.1016/j.jhydrol.2021.127346 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Two-dimensional semi-analytical solution of land-derived solute transport under tidal fluctuations considering variable boundary conditions on the seaward boundary | Transport of contaminants in coastal aquifers subject to tidal fluctuations is an important topic and a growing problem due to increasing populations and development in coastal areas. Many studies have used variable boundary conditions to simulate transport behavior at the interface between seawater and groundwater. However, to the best of our knowledge, no analytical solution accounting for variable-concentration boundary conditions exists for plume migration of land-derived contaminants passing through the inland zone of aquifers under tidally induced periodic flow. Here, a two-dimensional (2D) semi-analytical solution for land-derived solute transport was developed with variable boundary conditions at the seaward boundary under tidal fluctuations. The proposed 2D semi-analytical solution was verified through comparison with an existing one-dimensional semi-analytical solution and a 2D numerical solution developed using the finite-element method. Sensitivity analysis was performed to explore factors including hydraulic properties, tidal amplitude, and the location and distribution of initial contaminants, which affect the characteristics of land-derived pollutant transport in coastal aquifers. Through comparison of the calculated masses remaining over time in the aquifer using the proposed semi-analytical solution under two types of variable boundary conditions (Dirichlet-Neumann and Cauchy-Neumann variable boundary conditions), we found that the Cauchy-Neumann variable boundary conditions reflected reality better than did the Dirichlet-Neumann variable boundary conditions. The proposed analytical solution will be useful for obtaining insights into the mechanisms that drive the plume behavior of contaminants such as radionuclides or toxic chemicals released into coastal aquifers of tidally affected systems. | Suk, Heejun; Chen, Jui-Sheng; Park, Eungyu; Han, Weon Shik | Korea Inst Geosci & Mineral Resources, Daejeon 34132, South Korea; Natl Cent Univ, Grad Inst Appl Geol, Taoyuan 320, Taiwan; Kyungpook Natl Univ, Dept Geol, 80 Daehak Ro, Daegu 41566, South Korea; Yonsei Univ, Dept Earth Syst Sci, 50 Yonsei Ro, Seoul 03722, South Korea | Han, Weon Shik/KCY-0126-2024 | 23996203400; 7501893250; 23995577700; 57226420125 | juischen@ncu.edu.tw; | JOURNAL OF HYDROLOGY | J HYDROL | 0022-1694 | 1879-2707 | 606 | SCIE | ENGINEERING, CIVIL;GEOSCIENCES, MULTIDISCIPLINARY;WATER RESOURCES | 2022 | 6.4 | 7.2 | 0.52 | 2025-06-25 | 5 | 5 | Cauchy-Neumann variable boundary conditions; Land-derived solute transport; Proposed 2D semi-analytical solution; Tidally induced; Variable boundary conditions | SALTWATER INTRUSION; SIMULATION; MODEL | Cauchy-Neumann variable boundary conditions; Land-derived solute transport; Proposed 2D semi-analytical solution; Tidally induced; Variable boundary conditions | Aquifers; Boundary conditions; Groundwater pollution; Groundwater resources; Hydrogeology; Numerical methods; Sensitivity analysis; Solute transport; Cauchy-neumann variable boundary condition; Coastal aquifers; Land-derived solute transport; Neumann; Proposed 2d semi-analytical solution; Semi-analytical solution; Tidal fluctuation; Tidally induced; Variable boundary conditions; aquifer; boundary condition; pollutant transport; solute transport; toxicity; two-dimensional modeling; Contamination | English | 2022 | 2022-03 | 10.1016/j.jhydrol.2022.127441 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Aberrant functional connectivity of neural circuits associated with thought-action fusion in patients with obsessive-compulsive disorder | Background Cognitive theories of obsessive-compulsive disorder (OCD) stress the importance of dysfunctional beliefs in the development and maintenance of the disorder. However, a neurobiological understanding of these cognitive models, including thought-action fusion (TAF), is surprisingly lacking. Thus, this functional magnetic resonance imaging study aimed to investigate whether altered functional connectivity (FC) is associated with the TAF paradigm in OCD patients. Methods Forty-one OCD patients and 47 healthy controls (HCs) participated in a functional magnetic resonance imaging study using a TAF task, in which they were asked to read the name of a close or a neutral person in association with positive and negative statements. Results The conventional TAF condition (negative statements/close person) induced significant FC between the regions of interest (ROIs) identified using multivoxel pattern analysis and the visual association areas, default mode network subregions, affective processing, and several subcortical regions in both groups. Notably, sparser FC was observed in OCD patients. Further analysis confined to the cortico-striato-thalamo-cortical (CSTC) and affective networks demonstrated that OCD patients exhibited reduced ROI FC with affective regions and greater ROI FC with CSTC components in the TAF condition compared to HCs. Within the OCD patients, middle cingulate cortex-insula FC was correlated with TAF and responsibility scores. Conclusions Our TAF paradigm revealed altered context-dependent engagement of the CSTC and affective networks in OCD patients. These findings suggest that the neurobiology of cognitive models corresponds to current neuroanatomical models of OCD. Further, they elucidate the underlying neurobiological mechanisms of OCD at the circuit-based level. | Lee, Sang Won; Song, Huijin; Jang, Tae Yang; Cha, Hyunsil; Kim, Eunji; Chang, Yongmin; Lee, Seung Jae | Kyungpook Natl Univ, Chilgok Hosp, Dept Psychiat, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Psychiat, Daegu, South Korea; Seoul Natl Univ Hosp, Biomed Res Inst, Seoul, South Korea; Kyungpook Natl Univ Hosp, Dept Psychiat, Daegu, South Korea; Kyungpook Natl Univ, Dept Med & Biol Engn, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Mol Med, Daegu, South Korea; Kyungpook Natl Univ Hosp, Dept Radiol, Daegu, South Korea | Lee, Seung/AAI-1191-2020 | 55820414800; 8231186700; 57219848497; 57189728122; 57215273419; 7501840633; 58509400200 | ychang@knu.ac.kr;jayleemd@knu.ac.kr; | PSYCHOLOGICAL MEDICINE | PSYCHOL MED | 0033-2917 | 1469-8978 | 52 | 11 | SCIE;SSCI | PSYCHIATRY;PSYCHOLOGY, CLINICAL;PSYCHOLOGY | 2022 | 6.9 | 7.3 | 1.11 | 2025-06-25 | 10 | 12 | Affective network; cognitive theory; cortico-striato-thalamo-cortical network; functional connectivity; obsessive-compulsive disorder; thought-action fusion | DEFAULT MODE; BRAIN; METAANALYSIS; AMYGDALA; RESPONSIBILITY; NEUROBIOLOGY; EMOTION; SYSTEM; OCD | Affective network; cognitive theory; cortico-striato-Thalamo-cortical network; functional connectivity; obsessive-compulsive disorder; thought-Action fusion | Gyrus Cinguli; Humans; Magnetic Resonance Imaging; Obsessive-Compulsive Disorder; cingulate gyrus; diagnostic imaging; human; nuclear magnetic resonance imaging; obsessive compulsive disorder; procedures | English | 2022 | 2022-08 | 10.1017/s0033291720003980 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Longitudinal symptom network structure in first-episode psychosis: a possible marker for remission | Background Network approach has been applied to a wide variety of psychiatric disorders. The aim of the present study was to identify network structures of remitters and non-remitters in patients with first-episode psychosis (FEP) at baseline and the 6-month follow-up. Methods Participants (n = 252) from the Korean Early Psychosis Study (KEPS) were enrolled. They were classified as remitters or non-remitters using Andreasen's criteria. We estimated network structure with 10 symptoms (three symptoms from the Positive and Negative Syndrome Scale, one depressive symptom, and six symptoms related to schema and rumination) as nodes using a Gaussian graphical model. Global and local network metrics were compared within and between the networks over time. Results Global network metrics did not differ between the remitters and non-remitters at baseline or 6 months. However, the network structure and nodal strengths associated with positive-self and positive-others scores changed significantly in the remitters over time. Unique central symptoms for remitters and non-remitters were cognitive brooding and negative-self, respectively. The correlation stability coefficients for nodal strength were within the acceptable range. Conclusion Our findings indicate that network structure and some nodal strengths were more flexible in remitters. Negative-self could be an important target for therapeutic intervention. | Piao, Yan Hong; Yun, Je-Yeon; Nguyen, Thong Ba; Kim, Woo-Sung; Sui, Jing; Kang, Nam-In; Lee, Keon-Hak; Ryu, Seunghyong; Kim, Sung-Wan; Lee, Bong Ju; Kim, Jung Jin; Yu, Je-Chun; Lee, Kyu Young; Won, Seung-Hee; Lee, Seung-Hwan; Kim, Seung-Hyun; Kang, Shi Hyun; Kim, Euitae; Chung, Young Chul | Chonbuk Natl Univ, Dept Psychiat, Med Sch, Jeonju, South Korea; Chonbuk Natl Univ, Res Inst Clin Med, Biomed Res Inst, Chonbuk Natl Univ Hosp, Jeonju, South Korea; Seoul Natl Univ Hosp, Seoul, South Korea; Seoul Natl Univ, Yeongeon Student Support Ctr, Coll Med, Seoul, South Korea; Chinese Acad Sci, Brainnetome Ctr, Beijing 100190, Peoples R China; Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing 100190, Peoples R China; Chinese Acad Sci, Univ Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Beijing 100049, Peoples R China; Maeumsarang Hosp, Dept Psychiat, Wonju, Jeoiiabuk Do, South Korea; Chonnam Natl Univ, Dept Psychiat, Med Sch, Gwangju, South Korea; Inje Univ, Haeundae Paik Hosp, Dept Psychiat, Coll Med, Busan, South Korea; Catholic Univ Korea, Dept Psychiat, Seoul St Marys Hosp, Seoul, South Korea; Eulji Univ, Eulji Univ Hosp, Dept Psychiat, Sch Med, Daejeon, South Korea; Eulji Univ, Eulji Gen Hosp, Dept Psychiat, Sch Med, Seoul, South Korea; Kyungpook Natl Univ, Dept Psychiat, Sch Med, Daegu, South Korea; Inje Univ, Dept Psychiat, Coll Med, Goyang, South Korea; Korea Univ, Guro Hosp, Dept Psychiat, Coll Med, Seoul, South Korea; Seoul Natl Hosp, Dept Psychiat, Seoul, South Korea; Seoul Natl Univ, Dept Psychiat, Bundang Hosp, Seongnam, South Korea | ; Kim, Woo-Sung/L-9560-2017; Lee, Yo Han/IUN-3410-2023; Kim, Jungjin/MTF-3196-2025; Nguyen, Ba Thong/ADQ-2780-2022; Lee, Jungmin/KHT-2438-2024; SUI, JING/B-3455-2018; Chung, Young/AAB-8242-2022; Sui, Jing/B-3455-2018 | 57205143111; 55271657400; 56956064000; 57205973432; 56579803600; 56767602100; 35748813000; 16064491100; 47962371200; 59053777300; 36079817200; 56022915400; 24376890800; 35278955600; 56739411100; 57196226681; 36523091800; 55756823600; 55712695800 | chungyc@jbnu.ac.kr; | PSYCHOLOGICAL MEDICINE | PSYCHOL MED | 0033-2917 | 1469-8978 | 52 | 14 | SCIE;SSCI | PSYCHIATRY;PSYCHOLOGY, CLINICAL;PSYCHOLOGY | 2022 | 6.9 | 7.3 | 0.81 | 2025-06-25 | 12 | 8 | First-episode psychosis; network analysis; prediction; remission | SCHIZOPHRENIA; DISORDER; ASSOCIATIONS; PREDICTORS; DEPRESSION; RUMINATION; PATHWAYS; PARANOIA; TRAUMA; SCALE | First-episode psychosis; network analysis; prediction; remission | Humans; Psychiatric Status Rating Scales; Psychotic Disorders; human; psychological rating scale; psychology; psychosis | English | 2022 | 2022-10 | 10.1017/s0033291720005280 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Nelonemdaz for Patients With Acute Ischemic Stroke Undergoing Endovascular Reperfusion Therapy: A Randomized Phase II Trial | BACKGROUND: Nelonemdaz is a multitarget neuroprotectant that selectively blocks N-methyl-D-aspartate receptors and scavenges free radicals, as proven in preclinical ischemia-reperfusion studies. We aimed to evaluate the safety and efficacy of nelonemdaz in patients with acute ischemic stroke receiving endovascular reperfusion therapy. METHODS: This phase II randomized trial involved participants with large-artery occlusion in the anterior circulation at baseline who received endovascular reperfusion therapy <8 hours from symptom onset at 7 referral stroke centers in South Korea between October 29, 2016, and June 1, 2020. Two hundred thirteen patients were screened and 209 patients were randomly assigned at a 1:1:1 ratio using a computer-generated randomization system. Patients were divided into 3 groups based on the medication received-placebo, low-dose (2750 mg) nelonemdaz, and high-dose (5250 mg) nelonemdaz. The primary outcome was the proportion of patients with modified Rankin Scale scores of 0-2 at 12 weeks. RESULTS: Two hundred eight patients were assigned to the placebo (n=70), low-dose (n=71), and high-dose (n=67) groups. The groups had similar baseline characteristics. The primary outcome was achieved in 183 patients, and it did not differ among the groups (33/61 [54.1%], 40/65 [61.5%], and 36/57 [63.2%] patients; P=0.5578). The common odds ratio (90% CI) indicating a favorable shift in the modified Rankin Scale scores at 12 weeks was 1.55 (0.92-2.60) between the placebo and low-dose groups and 1.61 (0.94-2.76) between the placebo and high-dose groups. No serious adverse events were reported. CONCLUSIONS: The study arms showed no significant difference in the proportion of patients achieving modified Rankin Scale scores of 0-2 at 12 weeks. Nevertheless, nelonemdaz-treated patients showed a favorable tendency toward achieving these scores at 12 weeks, without serious adverse effects. Thus, a large-scale phase III trial is warranted. | Hong, Ji Man; Lee, Jin Soo; Lee, Yeong-Bae; Shin, Dong Hoon; Shin, Dong-Ick; Hwang, Yang-Ha; Ahn, Seong Hwan; Kim, Jae Guk; Sohn, Sung-Il; Kwon, Sun U.; Lee, Ji Sung; Gwag, Byoung Joo; Chamorro, Angel; Choi, Dennis W. | Ajou Univ, Med Ctr, Dept Neurol, Sch Med, Suwon, South Korea; Gachon Univ, Dept Neurol, Gil Med Ctr, Incheon, South Korea; Chungbuk Natl Univ, Chungbuk Natl Univ Hosp, Dept Neurol, Coll Med, Seoul, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Neurol, Seoul, South Korea; Chosun Univ, Coll Med, Dept Neurol, Gwangju, South Korea; Eulji Univ, Daejeon Eulji Med Ctr, Dept Neurol, Daejeon, South Korea; Keimyung Univ, Dongsan Med Ctr, Dept Neurol, Daejeon, South Korea; Univ Ulsan, Asan Med Ctr, Dept Neurol, Coll Med, Seoul, South Korea; Univ Ulsan, Clin Res Ctr, Asan Med Ctr, Coll Med, Seoul, South Korea; Yonsei Univ, Coll Life Sci & Biotechnol, Dept Biotechnol, Seoul, South Korea; Chungbuk Natl Univ Hosp, Daejeon, South Korea; Univ Ulsan, Asan Med Ctr, Coll Med, Ulsan, South Korea | HWANG, Yang-Ha/F-3068-2013; Hong, Ji Man/AAE-2686-2022; Lee, Wang-Soo/AAS-1477-2021; Kim, Jae/W-6208-2019; Shin, Dong-Ick/JPK-0914-2023 | 55729426200; 55963063300; 16310028600; 57222389564; 23989448700; 7402311308; 57200401172; 56720623400; 36479287000; 7402624264; 57212925539; 7005830426; 56050081900; 7401643634; 57953323800; 24471039500; 55722501000; 56197650500; 57194420191; 57193350744; 55931654800; 57954243500; 57954717600; 57954476500 | dacda@hanmail.net; | STROKE | STROKE | 0039-2499 | 1524-4628 | 53 | 11 | SCIE | CLINICAL NEUROLOGY;PERIPHERAL VASCULAR DISEASE | 2022 | 8.4 | 7.3 | 2.96 | 2025-06-25 | 21 | 23 | cerebral infarction; ischemic stroke; neuroprotective agent; odds ratio; reperfusion | INTRAARTERIAL TREATMENT; NMDA RECEPTOR; NEU2000; THROMBECTOMY; NXY-059; RECANALIZATION; HYPOTHERMIA; ANTAGONIST; TELEPHONE; PROTOCOL | cerebral infarction; ischemic stroke; neuroprotective agent; odds ratio; reperfusion | Brain Ischemia; Endovascular Procedures; Humans; Ischemic Stroke; Neuroprotective Agents; Receptors, N-Methyl-D-Aspartate; Reperfusion; Stroke; Thrombectomy; Treatment Outcome; alteplase; nelonemdaz; placebo; n methyl dextro aspartic acid receptor; neuroprotective agent; acute ischemic stroke; adult; aged; artery occlusion; Article; aspiration pneumonia; Barthel index; brain hemorrhage; clinical outcome; clinical practice; constipation; controlled study; coughing; diarrhea; double blind procedure; drug efficacy; drug megadose; drug safety; fever; headache; hematuria; human; low drug dose; major clinical study; mechanical thrombectomy; mortality; National Institutes of Health Stroke Scale; neuroprotection; phase 2 clinical trial; randomized controlled trial; Rankin scale; reperfusion; risk factor; South Korea; urine retention; adverse event; brain ischemia; cerebrovascular accident; clinical trial; endovascular surgery; thrombectomy; treatment outcome | English | 2022 | 2022-11 | 10.1161/strokeaha.122.039649 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Relationship between CRISPR sequence type and antimicrobial resistance in avian pathogenic Escherichia coli | Avian pathogenic Escherichia coli (APEC) is a primary cause of extraintestinal disease and respiratory infections in chickens; therefore, various antimicrobials applied via mass medication in farms to control APEC in Korea. In this study, we analyzed the relationship between CRISPR sequence type and antimicrobial resistance (AMR) in APEC isolates. Based on spacer distribution, a total of 103 CRISPR-positive APEC isolates were classified into 25 E. coli sequence types (ESTs), largely into two clusters that were correlated with phylogenetic groups: isolates appearing to have CRISPR 1 and/or 2 (93.2 %) and those having CRISPR 3 and 4 (6.8 %). Moreover, ESTs were divided into three AMR pattern-based groups: cephems-resistant group, non-cephems-resistant group, and antimicrobial sensitive group. There were significant differences among the groups (p < 0.05). Sixteen of the 25 ESTs had a significantly higher distribution of multidrug-resistant (MDR) isolates than the other ESTs (p < 0.05), and the ratio of MDR isolates was significantly higher than that of non-MDR isolates in the CRISPR 1 and 2 arrays (p < 0.05). A total of 9 protospacers were identified with protospacer, with protospacer 1 in CRISPR 1 being the most prevalent among the isolates (41.7 %). The protospacers of CRISPR 1 and 2 loci were associated with protection against external invaders such as bacteriophage or endogenous gene regulation. However, each protospacer of the CRISPR 3 and 4 loci originated from genes associated with AMR plasmids. These results indicate that CRISPR sequence type can improve AMR bacteria and enhance strategies for tackling the complexity of AMR in bacterial pathogens. | Kim, Koeun; Lee, Young Ju | Kyungpook Natl Univ, Coll Vet Med, Daegu 41566, South Korea; Kyungpook Natl Univ, Zoonoses Res Inst, Daegu 41566, South Korea | 57220805028; 56612134500 | youngju@knu.ac.kr; | VETERINARY MICROBIOLOGY | VET MICROBIOL | 0378-1135 | 1873-2542 | 266 | SCIE | MICROBIOLOGY;VETERINARY SCIENCES | 2022 | 3.3 | 7.3 | 0.31 | 2025-06-25 | 2 | 2 | Avian pathogenic Escherichia coli; Antimicrobial resistance; CRISPR; Broilers | ANTIBIOTIC-RESISTANCE; REPEATS CRISPRS; VIRULENCE; IDENTIFICATION; GENES; PREVALENCE; DIVERSITY; STRAINS; SPACERS; LOCI | Antimicrobial resistance; Avian pathogenic Escherichia coli; Broilers; CRISPR | Animals; Anti-Bacterial Agents; Chickens; Clustered Regularly Interspaced Short Palindromic Repeats; Drug Resistance, Bacterial; Escherichia coli; Escherichia coli Infections; Phylogeny; Poultry Diseases; ampicillin; antibiotic agent; cefadroxil; cefalexin; cefazolin; cefepime; cefotaxime; cefoxitin; ceftazidime; cefuroxime; chloramphenicol; ciprofloxacin; clavulanic acid; cotrimoxazole; gentamicin; nalidixic acid; tetracycline; antiinfective agent; antibiotic resistance; Article; avian pathogenic Escherichia coli; bacteriophage; bacterium isolate; clustered regularly interspaced short palindromic repeat; controlled study; gene control; multidrug resistant Escherichia coli; nonhuman; plasmid; animal; antibiotic resistance; bird disease; chicken; clustered regularly interspaced short palindromic repeat; Escherichia coli; Escherichia coli infection; genetics; microbiology; phylogeny; veterinary medicine | English | 2022 | 2022-03 | 10.1016/j.vetmic.2022.109338 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Role of Apparent Diffusion Coefficient Gradient Within Diffusion Lesions in Outcomes of Large Stroke After Thrombectomy | Background and Purpose: The outcome of endovascular treatment in stroke patients with a large ischemic core is not always satisfactory. We evaluated whether the severity of baseline diffusion-weighted imaging abnormalities, as assessed by different apparent diffusion coefficient (ADC) thresholds, correlates with the clinical outcome in these patients after successful endovascular treatment. Methods: In 82 consecutive patients with a large vessel occlusion in the anterior circulation admitted = 50 mL and successful recanalization by endovascular treatment were retrospectively investigated. Lesion volumes of 3 ADC thresholds (ADC(620), ADC <= 520x10(-6) mm(2)/s [ADC(520)], and ADC <= 540x10(-6) mm(2)/s [ADC(540)]) were measured using an automated Olea software program. The performance of the ADC(520)/ADC(620) and ADC(540)/ADC(620) ratios in predicting the functional outcome was assessed by receiver operating characteristic curve analysis. The ADC ratio with optimal threshold showing better receiver operating characteristic performance was dichotomized at its median value into low versus high subgroup and its association with the outcome subsequently evaluated in a multivariable logistic regression model. Results: The median baseline diffusion lesion volume was 80.8 mL (interquartile range, 64.4-105.4). A good functional outcome (modified Rankin Scale score, <= 2) was achieved in 35 patients (42.7%). The optimal threshold for predicting the functional outcome was identified as ADC(540)/ADC(620) (area under the curve, 0.833) and dichotomized at 0.674. After adjusting for age, baseline National Institutes of Health Stroke Scale score, intravenous tissue-type plasminogen activator, baseline diffusion lesion volume, and onset-to-recanalization time, a low ADC(540)/ADC(620) was independently associated with a good functional outcome (adjusted odds ratio, 10.72 [95% CI, 3.06-37.50]; P<0.001). Conclusions: A low ADC(540)/ADC(620), which may reflect less severe ischemic stress inside a diffusion lesion, may help to identify patients who would benefit from endovascular treatment despite having a large ischemic core. | Gwak, Dong-Seok; Choi, WooChan; Shim, Dong-Hyun; Kim, Yong-Won; Kang, Dong-Hun; Son, Wonsoo; Hwang, Yang-Ha | Kyungpook Natl Univ Hosp, Dept Neurol, 130 Dongdeok Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Neurol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Radiol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Neurosurg, Daegu, South Korea | HWANG, Yang-Ha/F-3068-2013 | 57205148053; 57225111001; 56779672200; 56203298200; 8977805800; 36676729400; 7402311308 | yangha.hwang@gmail.com; | STROKE | STROKE | 0039-2499 | 1524-4628 | 53 | 3 | SCIE | CLINICAL NEUROLOGY;PERIPHERAL VASCULAR DISEASE | 2022 | 8.4 | 7.3 | 1.54 | 2025-06-25 | 14 | 12 | cerebral infarction; diffusion magnetic resonance imaging; thrombectomy | ACUTE ISCHEMIC-STROKE; SAFE IMPLEMENTATION; SELECT PATIENTS; THROMBOLYSIS; VOLUME; RECANALIZATION; PREDICTS; THERAPY; BENEFIT; CORE | cerebral infarction; diffusion magnetic resonance imaging; thrombectomy | Aged; Aged, 80 and over; Diffusion Magnetic Resonance Imaging; Endovascular Procedures; Female; Humans; Ischemic Stroke; Male; Middle Aged; Prognosis; Retrospective Studies; Thrombectomy; Treatment Outcome; tissue plasminogen activator; acute ischemic stroke; aged; anterior circulation stroke; apparent diffusion coefficient; Article; blood vessel occlusion; cerebrovascular accident; clinical outcome; controlled study; diffusion weighted imaging; disease severity; endovascular surgery; female; human; lesion volume; major clinical study; male; National Institutes of Health Stroke Scale; neuroimaging; outcome assessment; Rankin scale; recanalization; receiver operating characteristic; retrospective study; stroke patient; thrombectomy; time; brain ischemia; diagnostic imaging; diffusion weighted imaging; middle aged; procedures; prognosis; thrombectomy; treatment outcome; very elderly | English | 2022 | 2022-03 | 10.1161/strokeaha.121.035615 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Understanding of the Lower Extremity Motor Recovery After First-Ever Ischemic Stroke | Background: We aimed to verify the validity of the proportional recovery model for the lower extremity. Methods: We reviewed clinical data of patients enrolled in the Korean Stroke Cohort for Functioning and Rehabilitation between August 2012 and May 2015. Recovery proportion was calculated as the amount of motor recovery over initial motor impairment, measured as the Fugl-Meyer Assessment of Lower Extremity score. We used the logistic regression method to model the probability of achieving the full Fugl-Meyer Assessment of Lower Extremity score, whereby we considered the ceiling effect of the score. To show the difference in the prevalence of achieving the full Fugl-Meyer Assessment of Lower Extremity score between 3 and 6 months poststroke, we constructed a marginal model through the generalized estimating equation method. We also performed the propensity score matching analysis to show the dependency of recovery proportion on the initial motor deficit at 3 and 6 months poststroke. Results: We evaluated 1085 patients. The recovery proportions at 3 and 6 months poststroke were 0.67 +/- 0.42 and 0.75 +/- 0.39, respectively. A 1-unit decrease in the initial neurological impairment and the age at stroke onset increased the probability of achieving the full Fugl-Meyer Assessment of Lower Extremity score, which occurred at both 3 and 6 months poststroke. The prevalence of those who reach full lower limb motor recovery differs significantly between 3 and 6 months poststroke. We also found out that the recovery proportion at both 3 and 6 months poststroke is determined by the initial motor deficits of the lower limb. These results are not consistent with the proportional recovery model. Conclusions: Our results demonstrated that the proportional recovery model for the lower limb is invalid. | Lee, Hyun Haeng; Sohn, Min Kyun; Kim, Deog Young; Shin, Yong-Il; Oh, Gyung-Jae; Lee, Yang-Soo; Joo, Min Cheol; Lee, So Young; Song, Min-Keun; Han, Junhee; Ahn, Jeonghoon; Lee, Young-Hoon; Chang, Won Hyuk; Choi, Soo Mi; Lee, Seon Kui; Lee, Jongmin; Kim, Yun-Hee | Konkuk Univ, Dept Rehabil Med, Med Ctr, Seoul, South Korea; Konkuk Univ, Sch Med, Seoul, South Korea; Chungnam Natl Univ, Dept Rehabil Med, Sch Med, Daejeon, South Korea; Yonsei Univ, Dept & Res Inst Rehabil Med, Coll Med, Seoul, South Korea; Pusan Natl Univ, Sch Med, Dept Rehabil Med, Yangsan Hosp, Pusan, South Korea; Wonkwang Univ, Dept Prevent Med, Sch Med, Iksan, South Korea; Wonkwang Univ, Dept Rehabil Med, Sch Med, Iksan, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Dept Rehabil Med, Sch Med, Daegu, South Korea; Jeju Natl Univ, Jeju Natl Univ Hosp, Dept Rehabil Med, Sch Med, Jeju, South Korea; Chonnam Natl Univ, Dept Phys & Rehabil Med, Med Sch, Gwangju, South Korea; Hallym Univ, Dept Stat, Chunchon, South Korea; Hallym Univ, Inst Stat, Chunchon, South Korea; Ewha Womans Univ, Dept Hlth Convergence, Seoul, South Korea; Sungkyunkwan Univ, Ctr Prevent & Rehabil, Samsung Med Ctr,Sch Med, Dept Phys & Rehabil Med,Heart Vasc Stroke Inst, Seoul, South Korea; Korea Dis Control & Prevent Agcy, Div Chron Dis Prevent, Cheongju, South Korea; Sungkyunkwan Univ, Dept Hlth Sci & Technol, Dept Med Device Management & Res, Dept Digital Hlth,SAIHST, Seoul, South Korea | Lee, Jongmin/Q-4909-2019; Ahn, Jeonghoon/CAA-1956-2022; kim, deog young/Q-8498-2019; Kim, Yun-Hee/GVS-6426-2022 | 57221571161; 7101840459; 55375583000; 55890990500; 7007056685; 57202952463; 56982599700; 57202327370; 55375416600; 57192890252; 8855402200; 55716155400; 35301717900; 57253230100; 57216396953; 57202882113; 57020121600 | leej@kuh.ac.kr;yun1225.kim@samsung.com; | STROKE | STROKE | 0039-2499 | 1524-4628 | 53 | 10 | SCIE | CLINICAL NEUROLOGY;PERIPHERAL VASCULAR DISEASE | 2022 | 8.4 | 7.3 | 0.64 | 2025-06-25 | 6 | 5 | brain; ischemia; ischemic stroke; lower extremity; recovery of function | PROPORTIONAL RECOVERY; IMPAIRMENT | brain; ischemia; ischemic stroke; lower extremity; recovery of function | Humans; Ischemic Stroke; Lower Extremity; Recovery of Function; Stroke; Stroke Rehabilitation; Upper Extremity; adult; aged; Article; clinical evaluation; clinical study; cohort analysis; convalescence; female; follow up; Fugl-Meyer Assessment for Lower Extremity; hospital admission; human; ischemic stroke; logistic regression analysis; lower limb; major clinical study; male; motor activity; motor dysfunction; motor performance; neurologic disease; prevalence; propensity score; stroke patient; very elderly; brain ischemia; cerebrovascular accident; convalescence; lower limb; procedures; stroke rehabilitation; upper limb | English | 2022 | 2022-10 | 10.1161/strokeaha.121.038196 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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