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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | Article | α-Glucosidase Inhibitory Activity of Phenolic Compounds Isolated from the Stems of Caesalpinia decapetala var. japonica | In our study, sixteen known phenolic compounds, including quercetin (1), methyl gallate (2), caesalpiniaphenol C (3), 8S,8′S,7′R-(‒)-lyoniresinol (4), 7,3′,5′-trihydroxyflavanone (5), sappanchalcone (6), sappanone A (7), taxifolin (8), fisetin (9), fustin (10), (+)-catechin (11), brazilin (12), 3,4,5-trimethoxyphenyl β-ᴅ-glucopyranoside (13), 1-(2-methylbutyryl)phloroglucinol-glucopyranoside (14), (+)-epi-catechin (15), and astragalin (16) and one mixture of two conformers of protosappanin B (17/18) were isolated from the stems of Caesalpinia decapetala var. japonica. Their structures were elucidated based on a comparison of their physicochemical and spectral data with those of literature. To the best of our knowledge, this represents the first isolation of compounds 3, 4, 8, 9, and 10 from C. decapetala and compounds 13 and 14 from the Caesalpinia genus. All the isolated compounds were evaluated for their inhibitory effect against the α-glucosidase enzyme. Among them, two flavonols (1 and 9), one chalcone (6), and one homoisoflavanone (7) exhibited an inhibitory effect on α-glucosidase action with an IC50 range value of 5.08 ‒ 15.01 µM, stronger than that of the positive control (acarbose, IC50 = 152.22 μM). Kinetic analysis revealed that compounds 1 and 9 showed non-competitive α-glucosidase inhibition, while the inhibition type was mixed for compounds 6 and 7. © 2022, Korean Society of Pharmacognosy. All rights reserved. | Le, Thi Thanh; Ha, Manh Tuan; Hoang, Le Minh; Vu, Ngoc Khanh; Kim, Jeong Ah; Min, Byung Sun | College of Pharmacy, Drug Research and Development Center, Daegu Catholic University, Gyeongbuk, 38430, South Korea; College of Pharmacy, Drug Research and Development Center, Daegu Catholic University, Gyeongbuk, 38430, South Korea; College of Pharmacy, Drug Research and Development Center, Daegu Catholic University, Gyeongbuk, 38430, South Korea; College of Pharmacy, Drug Research and Development Center, Daegu Catholic University, Gyeongbuk, 38430, South Korea; College of Pharmacy, Research Institute of Pharmaceutical Science, Kyungpook National University, Daegu, 41566, South Korea; College of Pharmacy, Drug Research and Development Center, Daegu Catholic University, Gyeongbuk, 38430, South Korea | 57350699400; 57189040434; 59888078300; 57217172502; 24722570900; 55663638200 | bsmin@cu.ac.kr; | Natural Product Sciences | 1226-3907 | 28 | 3 | 1.03 | 2025-06-25 | 10 | anti-diabetic; Caesalpinia decapetala var. japonica; flavonoids; Leguminosae; α-glucosidase | acarbose; alpha glucosidase; antidiabetic agent; astragalin; brazilin; caesalpiniaphenol C; catechin; chalcone; fisetin; flavonoid; fustin; gallic acid methyl ester; hesperetin; methanol; phenol derivative; protosappanin B; quercetin; sappanchalcone; sappanone A; sodium carbonate; taxifolin; unclassified drug; antidiabetic activity; Article; biological activity; Caesalpinia; carbon nuclear magnetic resonance; chemical composition; column chromatography; drug synthesis; electrospray mass spectrometry; enzyme activity; enzyme inhibition; Fabaceae; high performance liquid chromatography; hyperglycemia; IC50; kinetics; nonhuman; nuclear magnetic resonance; physical chemistry; phytochemistry; protein function; proton nuclear magnetic resonance; thin layer chromatography | English | Final | 2022 | 10.20307/nps.2022.28.3.143 | 바로가기 | 바로가기 |
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