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| ○ | Article | Real-world Treatment Patterns in Patients with EGFR Mutation-positive NSCLC Receiving a First-Line, First- or Second-generation EGFR Tyrosine Kinase Inhibitor in South Korea and Taiwan | Introduction: The preferred first-line (1L) treatment for epidermal growth factor receptor (EGFR)mutation-positive (EGFRm) advanced/metastatic non-small lung cancer (NSCLC) are EGFR-tyrosine kinase inhibitors (TKIs). However, most patients treated with 1L first- or second-generation (1G/2G) EGFR-TKIs acquire resistance; the EGFR T790M mutation is observed in ~30–50% of patients. We report real-world NSCLC treatment and T790M testing patterns in South Korea and Taiwan. Methods: Retrospective medical record review of EGFRm advanced/metastatic NSCLC patients from routine practice. 1G/2G EGFR-TKI initiation 1 January 2015–31 December 2017 (follow-up end date: last available medical record or August 2019). Study measures: demographic/disease characteristics, 1L/2L treatment, T790M testing. Results: In South Korea, 70% (164/235) and in Taiwan 89% (89/100) experienced 1L disease progression (median [range] follow-up: 22 [2.3–50.7] months). Of those with disease progression, 68% (111/164) and 62% (55/89) had T790M testing in South Korea and Taiwan, respectively. In South Korea, 43% (48/111) were T790M-positive with 88% (n=42/48) receiving osimertinib (mostly 2L). In Taiwan, 18% (10/55) were T790M-positive; 100% received osimertinib. Overall, 73% (120/164) and 63% (63/100) in South Korea and Taiwan, respectively, received 2L therapy, predominantly pemetrexed-containing regimens. Among patients with disease progression, 9% (14/164) and 24% (21/89) died before receiving 2L therapy in South Korea and Taiwan, respectively. Conclusion: In both countries, <70% with 1L disease progression were tested for T790M at any point from NSCLC diagnosis, suggesting resistance mutation testing could be improved. Treatment/testing patterns may have changed in both countries since study initiation due to osimertinib reimbursement changes beginning December 2017. © This work is licensed under a Creative Commons Attribution-Non Commercial 4.0 International License. | Lee, Jae Cheo; Hung, Jen-Yu; Kim, Young-Chul; Chang, Gee-Chen; Yoo, Seung Soo; Yang, Sheng Hsiung; Davis, Keith L; Nagar, Saurabh P; Taylor, Aliki; Lee, Sung Yong; Shih, Jin Yuan | Department of Oncology, Asan Medical Center, University of Ulsan, College of Medicine, Seoul, South Korea; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan, Department of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan; Department of Internal Medicine, Chonnam National University Medical School and Lung Cancer Clinic, Pulmonary Medicine, Chonnam National University Hwasun Hospital, Jeonnam, South Korea; Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan; Lung Cancer Center, Kyungpook National University Chilgok Hospital, Daegu, South Korea; Mackay Memorial Hospital, Taipei, Taiwan; Health Economics Group, RTI Health Solutions, Research Triangle Park, Durham, NC, United States; Health Economics Group, RTI Health Solutions, Research Triangle Park, Durham, NC, United States; Oncology Business Unit, AstraZeneca, Cambridge, United Kingdom; Pulmonology, Allergy and Critical Care Medicine, Korea University Guro Hospital, Seoul, South Korea; Division of Pulmonary and Critical Care Medicine, National Taiwan University Hospital, Taipei, Taiwan | 24825051600; 7201963659; 35201246200; 7402308947; 56479781600; 55587356500; 8580403600; 28567922400; 57193217078; 56734650000; 57466329000 | jclee@amc.seoul.kr; | Asia Pacific Journal of Cancer Biology | 2538-4635 | 6 | 2 | 0.41 | 2025-07-30 | 6 | EGFR mutation; EGFR-TKI; NSCLC; osimertinib; T790M | afatinib; anaplastic lymphoma kinase inhibitor; bevacizumab; carboplatin; cisplatin; crizotinib; docetaxel; epidermal growth factor receptor; erlotinib; gefitinib; gemcitabine; nivolumab; osimertinib; paclitaxel; pembrolizumab; pemetrexed; protein tyrosine kinase inhibitor; vincristine; adult; advanced cancer; aged; Article; cancer patient; central nervous system metastasis; clinical article; clinical assessment; clinical practice; cohort analysis; controlled study; disease exacerbation; female; follow up; gene mutation; human; male; medical record; medical record review; middle aged; non small cell lung cancer; outcome assessment; personal experience; retrospective study; South Korea; Taiwan; treatment duration; treatment indication; very elderly | English | Final | 2021 | 10.31557/apjcb.2021.6.2.123-132 | 바로가기 | 바로가기 | |||||||||||||||
| ○ | Proceedings Paper | Recent advances in ADL, CutLang and adl2tnm | This paper presents an overview and features of an Analysis Description Language (ADL) designed for HEP data analysis. ADL is a domain specific, declarative language that describes the physics content of an analysis in a standard and unambiguous way, independent of any computing frameworks. It also describes infrastructures that render ADL executable, namely CutLang, a direct runtime interpreter (originally also a language), and adl2tnm, a transpiler converting ADL into C++ code. In ADL, analyses are described in human readable plain text files, clearly separating object, variable and event selection definitions in blocks, with a syntax that includes mathematical and logical operations, comparison and optimisation operators, reducers, four-vector algebra and commonly used functions. Recent studies demonstrate that adapting the ADL approach has numerous benefits for the experimental and phenomenological HEP communities. These include facilitating the abstraction, design, optimization, visualization, validation, combination, reproduction, interpretation and overall communication of the analysis contents and long term preservation of the analyses beyond the lifetimes of experiments. Here we also discuss some of the current ADL applications in physics studies and future prospects based on static analysis and differentiable programming. | Prosper, Harrison B.; Sekmen, Sezen; Unel, Gokhan; Paul, Arpon | Florida State Univ, Dept Phys, Tallahassee, FL 32306 USA; Kyungpook Natl Univ, Ctr High Energy Phys, Daegu, South Korea; Univ Calif Irvine, Phys & Astron Dept, Irvine, CA USA; Abdus Salam Int Ctr Theoret Phys, Trieste, Italy | unel, gokhan/KFB-1065-2024 | harry@hep.fsu.edu;ssekmen@cern.ch;gokhan.unel@cern.ch;apaul@ictp.it; | 25TH INTERNATIONAL CONFERENCE ON COMPUTING IN HIGH ENERGY AND NUCLEAR PHYSICS, CHEP 2021 | 2100-014X | 251 | 0 | MODEL; SMODELS; LHC | English | 2021 | 2021 | 10.1051/epjconf/202125103062 | 바로가기 | 바로가기 | |||||||||||||||||||
| ○ | ○ | Review | Recent advances in ultra-low temperature (sub-zero to 100 °C) synthesis, mechanism and applications of titania (TiO2) nanoparticles | The development of titania (TiO2) nanomaterials for next-generation photonic, optoelectronic, and catalytic applications necessitates a facile and cost-effective synthetic methodology for precisely tuning the composition, phase, and morphology at nanometer scales. In this review, an attempt has been made to comprehend the progress of the emerging and rapidly developing synthesis methods evolved for the low-temperature synthesis of titania with a particular emphasis on sub-zero temperature. Insights and understandings of how the temperature affects the characteristic surface properties and morphology of titania, along with a detailed discussion on the material characteristics for various technological device applications are dealt with various methods of analysis. Furthermore, the temperature-dependent morphological (0D-3D) and structural changes and their impact on different energy-harvesting and storage and water remediation applications are elucidated. Thus, this review specifically opens the understanding of different TiO2 polymorph syntheses and their physiochemical comprehension for advanced technological device performance enhancement. | Shejale, Kiran P.; Krishnapriya, R.; Patil, Harshala; Laishram, Devika; Rawal, Pratyush; Sharma, Rakesh K. | Kyungpook Natl Univ, Sch Mech Engn, Mech & Electrochem Funct Mat MEFM Lab, Daegu 41566, South Korea; Indian Inst Technol Jodhpur, Dept Chem, Sustainable Mat & Catalysis Res Lab SMCRL, Jodhpur 342037, Rajasthan, India; United Arab Emirate Univ, Dept Mech Engn, Coll Engn, Al Ain 15551, U Arab Emirates; Indian Inst Technol, Ctr Technol Alternat Rural Areas, Mumbai 400076, Maharashtra, India; Univ Coll Dublin, Sch Chem & Bioproc Engn, Engn Bldg, Dublin 4, Ireland; Univ Colorado Boulder, Dept Elect Comp & Energy Engn, 425 UCB, Boulder, CO 80309 USA | KRISHNAPRIYA, R/D-3564-2017; Shejale, Kiran/G-3183-2019; Sharma, FRSC, Rakesh/C-8270-2015; Sharma, FRSC, MRACI CChem,, Rakesh/C-8270-2015; Krishnapriya, R./D-3564-2017; Laishram, Devika/IUM-8980-2023 | 57063450100; 56941852400; 57210191217; 57063210400; 57362922500; 58266758200 | rks@iitj.ac.in; | MATERIALS ADVANCES | MATER ADV | 2633-5409 | 2 | 23 | ESCI | MATERIALS SCIENCE, MULTIDISCIPLINARY | 2021 | N/A | 0.35 | 2025-07-30 | 17 | 24 | MICROWAVE-SOLVOTHERMAL SYNTHESIS; PHOTOCATALYTIC ACTIVITY; ELECTROPHORETIC DEPOSITION; ROOM-TEMPERATURE; IONIC-LIQUID; DIOXIDE NANOMATERIALS; ASSISTED SYNTHESIS; PHASE-TRANSITION; NONAQUEOUS SYNTHESIS; OXIDE NANOPARTICLES | Alkylation; Biogeochemistry; Nanoclay; Synthesis (chemical); TiO2 nanoparticles; C application; C-synthesis; Catalytic applications; Cost effective; Optoelectronic applications; Photonic application; Synthesis mechanism; TiO 2; Titania; Ultra low temperatures; Titanium dioxide | English | 2021 | 2021-11-29 | 10.1039/d1ma00942g | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Review | Recent Research Trend of Biosensors for Colorectal Cancer Specific Protein Biomarkers | Colorectal cancer (CRC) is one of the most prevalent diseases in modern society, constituting a serious threat to global health. Currently, routine clinical screening and early removal of precancerous polyps are the most successful methods for reducing CRC incidence and mortality. However, the high cost and invasive detection of sigmoidoscopy and colonoscopy limited the CRC-screening participation and prevention. The emergence of biosensors provides an inexpensive, sensitive, less invasive tool for detecting CRC disease biomarkers. This review highlights some of recent efforts made on developing biosensors with electrochemical and optical techniques targeting CRC specific protein biomarkers for early diagnosis and prognosis, potential applications, and future perspectives. | Li, Jingjing; Si, Yunpei; Lee, Hye Jin | Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea | ; LEE, HYEJIN/W-1345-2018 | 57222707218; 57203850418; 56569175200 | jingjing.2018@outlook.com;yunpeith@hotmail.com;hyejinlee@knu.ac.kr; | APPLIED CHEMISTRY FOR ENGINEERING | APPL CHEM ENG | 1225-0112 | 1228-4505 | 32 | 3 | ESCI | ENGINEERING, CHEMICAL | 2021 | N/A | 0.13 | 2025-07-30 | 6 | 6 | Colorectal cancer; Protein biomarkers; Biosensors; Electrochemical methods; Optical techniques | LATERAL FLOW IMMUNOASSAY; CARCINOEMBRYONIC ANTIGEN; TECHNOLOGY; ELECTRODES; PLASMA; BLOOD; LUNG | Biosensors; Colorectal cancer; Electrochemical methods; Optical techniques; Protein biomarkers | English | 2021 | 2021-06 | 10.14478/ace.2021.1040 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Recurrent benign cementoblastoma: A case report and literature review | A 16-year-old male presented with pain in the right posterior mandible on chewing that had lasted for several months. The radiographic features of the lesion included a radiolucent-radiopaque mixed-density mass with a radiolucent rim attached to the root of the mandibular right first molar. The preliminary radiographic diagnosis was benign cementoblastoma, which was confirmed by histopathological examination following surgical excision. The lesion recurred 3 years after treatment; radiographically, it consisted of 3 round foci with mixed radiopacity, each with a radiolucent rim near the root of the mandibular right second premolar and the edentulous postoperative region. The lesion was diagnosed as recurrent benign cementoblastoma and a second surgery was scheduled. This report presented an unusual case of recurrent benign cementoblastoma following surgical excision and extraction of the involved tooth, along with a literature review on reported cases of recurrent benign cementoblastoma with a focus on its clinical features and the best treatment options. | Yoon, Yeong-Ah; Kwon, Young-Eun; Choi, So-Young; Choi, Karp-Shik; An, Seo-Young; An, Chang-Hyeon | Kyungpook Natl Univ, Sch Dent, Dept Oral & Maxillofacial Radiol, Daegu, South Korea; Doctor Dent Clin, Promise Dent Clin 7, Daegu, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Oral & Maxillofacial Surg, Daegu, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Oral & Maxillofacial Radiol, IHBR, Daegu, South Korea | ; kwon, Young Eun/KHW-2561-2024 | 57224362386; 57193750002; 57202918688; 55338954100; 55258203200; 17134437600 | chan@knu.ac.kr;syan@knu.ac.kr; | IMAGING SCIENCE IN DENTISTRY | IMAGNG SCI DENT | 2233-7822 | 2233-7830 | 51 | 4 | ESCI | DENTISTRY, ORAL SURGERY & MEDICINE | 2021 | N/A | 0.36 | 2025-07-30 | 5 | 3 | Odontogenic Tumor; Dental Cementum; Recurrence; Cone-Beam Computed Tomography; Radiography; Panoramic | English | 2021 | 2021-12 | 10.5624/isd.20210170 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | Article | Recurrent hepatic encephalopathy caused by the persistent porto-systemic shunt in liver transplant recipients | Introduction: Hepatic encephalopathy (HE) caused by porto-systemic shunt is one of the representative complications of liver cirrhosis, but HE is an infrequent condition after the full restoration of portal flow through liver transplantation, despite the persistence of porto-systemic shunts. We report two cases with a normal functioning liver graft and patent portal flow that developed recurrent HE after liver transplantation. Methods: We reviewed the medical record the two cases, liver transplant recipient represented HE with stable graft function. Results: The one case received a living donor liver transplantation (LDLT) with inferior vena cava (IVC) replacement because of Budd-Chiari Syndrome. Two months after LDLT, recurrent HE occurred despite of well-functioning liver graft and patent portal vein. An abdominal computed tomography scan (CT) showed large port-systemic collaterals between mesenteric vein and IVC. The other case transferred for the further evaluation of recurrent HE. She received a deceased donor liver transplantation, 9 years ago, and a HE with hyperammonemia was repeated, despite of normal liver function test. Persistent meso-caval collateral veins were identified on CT. After the closure of shunt by the interventional angiographic embolization, hyperammonemia and HE were completely resolved. Conclusions: Persistent porto-systemic shunts in liver transplant recipients with stable graft function may be the cause of HE. Therefore, when liver transplant patient with stable graft function represents HE, a more thorough evaluation is needed to identify the existence of persistent porto-systemic shunts that are very rare condition. © The Korean Association of Hepato-Biliary-Pancreatic Surgery. | Han, Jaryung; Han, Young Seok; Hwang, Yoon Jin | Department of Surgery, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu, South Korea; Department of Surgery, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu, South Korea; Department of Surgery, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu, South Korea | 57214671308; 7404096216; 7402310967 | gshys@knu.ac.kr; | Annals of Hepato-Biliary-Pancreatic Surgery | 2508-5778 | 25 | 0 | 2025-07-30 | 0 | English | Final | 2021 | 10.14701/ahbps.ep-74 | 바로가기 | 바로가기 | ||||||||||||||||||
| ○ | ○ | Proceedings Paper | Reducing Solid-State Drive Read Latency by Optimizing Read-Retry | 3D NAND flash memory with advanced multi-level cell techniques provides high storage density, but suffers from significant performance degradation due to a large number of read-retry operations. Although the read-retry mechanism is essential to ensuring the reliability of modern NAND flash memory, it can significantly increase the read latency of an SSD by introducing multiple retry steps that read the target page again with adjusted read-reference voltage values. Through a detailed analysis of the read mechanism and rigorous characterization of 160 real 3D NAND flash memory chips, we find new opportunities to reduce the read-retry latency by exploiting two advanced features widely adopted in modern NAND flash-based SSDs: 1) the CACHE READ command and 2) strong ECC engine. First, we can reduce the read-retry latency using the advanced CACHE READ command that allows a NAND flash chip to perform consecutive reads in a pipelined manner. Second, there exists a large ECC-capability margin in the final retry step that can be used for reducing the chip-level read latency. Based on our new findings, we develop two new techniques that effectively reduce the read-retry latency: 1) Pipelined Read-Retry (PR2) and 2) Adaptive Read-Retry (AR(2)). PR2 reduces the latency of a read-retry operation by pipelining consecutive retry steps using the CACHE READ command. AR(2) shortens the latency of each retry step by dynamically reducing the chip-level read latency depending on the current operating conditions that determine the ECC-capability margin. Our evaluation using twelve real-world workloads shows that our proposal improves SSD response time by up to 31.5% (17% on average) over a state-of-the-art baseline with only small changes to the SSD controller. | Park, Jisung; Kim, Myungsuk; Chun, Myoungjun; Orosa, Lois; Kim, Jihong; Mutlu, Onur | Swiss Fed Inst Technol, Zurich, Switzerland; Seoul Natl Univ, Seoul, South Korea; Kyungpook Natl Univ, Daegu, South Korea | Park, Jisung/AAL-7824-2021; park, jisung/KFA-8003-2024 | 56095781900; 57194859467; 57211568029; 55062282700; 57202122647; 16043006700 | ASPLOS XXVI: TWENTY-SIXTH INTERNATIONAL CONFERENCE ON ARCHITECTURAL SUPPORT FOR PROGRAMMING LANGUAGES AND OPERATING SYSTEMS | 4.02 | 2025-07-30 | 41 | 44 | solid state drives (SSDs); NAND flash memory; latency; read-retry | MEMORY; RETENTION; DRAM | 3D NAND flash memory; latency; read-retry; solid-state drives (SSDs) | Cache memory; Memory architecture; NAND circuits; Pipelines; 3-d nand flash memory; High storage density; NAND flash memory; Operating condition; Performance degradation; Reference voltages; Solid state drives; State of the art; Flash-based SSDs | English | 2021 | 2021 | 10.1145/3445814.3446719 | 바로가기 | 바로가기 | 바로가기 | |||||||||||||
| ○ | Article | Regional differences of mechanical properties in a biceps brachii following eccentric exercise | PURPOSE: This study aimed to examine the effects of eccentric exercise (ECC) on the indices of mechanical properties together with markers of exercise-induced muscle damage (EIMD) in different sites of the biceps brachii (BB) muscle. METHODS: ECC using an elbow joint was performed in 13 non-trained, college men. Global symptoms of EIMD were identified through changes in muscle soreness and serum creatine kinase (CK) activity, including muscle function following ECC. To evaluate regional EIMD, muscle swelling and tenderness as well as muscular echo intensity were measured at distal (4 cm above the elbow joint) and middle (30% of the distance from the antecubital crease to the acromion) sites within the BB muscle. A handheld myotonometer was used to estimate changes in mechanical properties, that is, oscillation frequency (F), dynamic stiffness (S), and relaxation time (R), of BB muscles after ECC. RESULTS: A significant difference in the major markers of EIMD, such as muscle soreness and serum CK activity, along with parameters of muscle function, was observed after ECC compared to baseline. Although all indirect markers of regional muscle damage demonstrated meaningful differences between before and after ECC, no statistically significant interaction between the distal and middle sites was observed in any of the markers. After ECC, both distal and middle sites showed significant changes in F, S, and R, but no statistical differences in changes in muscle mechanical properties were observed between localized muscle sites within BB muscles. CONCLUSIONS: Changes in mechanical properties, including regional muscle damage, seem to be uniformly influenced by differenanatomical locations within the BB muscle, such as elbow flexors, following ECC. © 2021 Korean Society of Exercise Physiology. | Kim, Choun-Sub; Kim, Maeng-Kyu | Sports Medicine Lab, Department of Physical Education, Kyungpook National University, Daegu, South Korea; Sports Medicine Lab, Department of Physical Education, Kyungpook National University, Daegu, South Korea | 57193441988; 26021932400 | kimmk@knu.ac.kr; | Exercise Science | 1226-1726 | 30 | 3 | 0 | 2025-07-30 | 0 | Biceps brachii; Eccentric exercise; Muscle mechanical properties; Regional muscle damage | Korean | Final | 2021 | 10.15857/ksep.2021.30.3.327 | 바로가기 | 바로가기 | ||||||||||||||||
| ○ | ○ | Article | Regulation of Nitrate (NO3) Transporters and Glutamate Synthase-Encoding Genes under Drought Stress in Arabidopsis: The Regulatory Role of AtbZIP62 Transcription Factor | Nitrogen (N) is an essential macronutrient, which contributes substantially to the growth and development of plants. In the soil, nitrate (NO3) is the predominant form of N available to the plant and its acquisition by the plant involves several NO3 transporters; however, the mechanism underlying their involvement in the adaptive response under abiotic stress is poorly understood. Initially, we performed an in silico analysis to identify potential binding sites for the basic leucine zipper 62 transcription factor (AtbZIP62 TF) in the promoter of the target genes, and constructed their protein-protein interaction networks. Rather than AtbZIP62, results revealed the presence of cis-regulatory elements specific to two other bZIP TFs, AtbZIP18 and 69. A recent report showed that AtbZIP62 TF negatively regulated AtbZIP18 and AtbZIP69. Therefore, we investigated the transcriptional regulation of AtNPF6.2/NRT1.4 (low-affinity NO3 transporter), AtNPF6.3/NRT1.1 (dual-affinity NO3 transporter), AtNRT2.1 and AtNRT2.2 (high-affinity NO3 transporters), and AtGLU1 and AtGLU2 (both encoding glutamate synthase) in response to drought stress in Col-0. From the perspective of exploring the transcriptional interplay of the target genes with AtbZIP62 TF, we measured their expression by qPCR in the atbzip62 (lacking the AtbZIP62 gene) under the same conditions. Our recent study revealed that AtbZIP62 TF positively regulates the expression of AtPYD1 (Pyrimidine 1, a key gene of the de novo pyrimidine biosynthesis pathway know to share a common substrate with the N metabolic pathway). For this reason, we included the atpyd1-2 mutant in the study. Our findings revealed that the expression of AtNPF6.2/NRT1.4, AtNPF6.3/NRT1.1 and AtNRT2.2 was similarly regulated in atzbip62 and atpyd1-2 but differentially regulated between the mutant lines and Col-0. Meanwhile, the expression pattern of AtNRT2.1 in atbzip62 was similar to that observed in Col-0 but was suppressed in atpyd1-2. The breakthrough is that AtNRT2.2 had the highest expression level in Col-0, while being suppressed in atbzip62 and atpyd1-2. Furthermore, the transcript accumulation of AtGLU1 and AtGLU2 showed differential regulation patterns between Col-0 and atbzip62, and atpyd1-2. Therefore, results suggest that of all tested NO3 transporters, AtNRT2.2 is thought to play a preponderant role in contributing to NO3 transport events under the regulatory influence of AtbZIP62 TF in response to drought stress. | Rolly, Nkulu Kabange; Yun, Byung-Wook | Kyungpook Natl Univ, Sch Appl Biosci, Lab Plant Funct Genom, Daegu 41566, South Korea; RDA, Dept Southern Area Crop Sci, Natl Inst Crop Sci, Miryang 50424, South Korea; Minist Agr, Natl Lab Seed Testing, Natl Seed Serv, SENASEM, 904KIN1, Kinshasa, DEM REP CONGO | KABANGE, NKULU/AAQ-9425-2020 | 57202031236; 8245123600 | rolly.kabange@gmail.com;bwyun@knu.ac.kr; | PLANTS-BASEL | 2223-7747 | 10 | 10 | 1.49 | 2025-07-30 | 15 | 15 | nitrogen use efficiency; nitrate transporters; nitrogen assimilation; AtbZIP62 transcription factor; AtPYD1; drought stress; Arabidopsis | PLANT NITROGEN ASSIMILATION; TO-SINK REMOBILIZATION; ROOT; NRT1.1; REDUCTION; CHL1; NUTRITION; COMPONENT; SHOOTS | Arabidopsis; AtbZIP62 transcription factor; AtPYD1; Drought stress; Nitrate transporters; Nitrogen assimilation; Nitrogen use efficiency | English | 2021 | 2021-10 | 10.3390/plants10102149 | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | ○ | Proceedings Paper | Reliable Interest Forwarding Strategy for Underwater Vehicular NDN | Named Data Networking (NDN) is an information centric networking paradigm designed to support future internet traffic. However, the conventional NDN communication mechanism lacks the ability to adapt the dynamic lossy underwater acoustic channel. With underwater producer and consumer mobility, NDN communication becomes more challenging. We propose an evolved NDN architecture for underwater vehicular named data networking (UV-NDN) that keeps record of personal and neighboring PIT with manager handling the interest packets and data packets. In addition, we introduce a periodic interest generation mechanism to make nodes in the close vicinity aware of the neighboring node personal PIT. Performance evaluation shows that UV-NDN outperforms conventional NDN. | Khan, Muhammad Toaha Raza; Saad, Malik Muhammad; Seo, Junho; Ahmed, Syed Hassan; Kim, Dongkyun | Kyungpook Natl Univ, Sch Comp Sci & Engn, Daegu, South Korea | ; Shah, Syed Hassan/E-5058-2014; Khan, Turyalai/HPH-0061-2023; Saad, Malik/ABF-9433-2021 | 57202044597; 57220715290; 57208740581; 55389144500; 35753648800 | toaha@knu.ac.kr;maliksaad@knu.ac.kr;junho@knu.ac.kr;sh.ahmed@ieee.org;dongkyun@knu.ac.kr; | 36TH ANNUAL ACM SYMPOSIUM ON APPLIED COMPUTING, SAC 2021 | 0.59 | 2025-07-30 | 6 | 10 | ACM proceedings; LATEX; text tagging | ACM proceedings; LATEX; text tagging | Marine communication; Communication mechanisms; Consumer mobilities; Forwarding strategies; Generation mechanism; Information-centric networkings; Named data networkings; Neighboring nodes; Underwater acoustic channels; Underwater acoustic communication | English | 2021 | 2021 | 10.1145/3412841.3442061 | 바로가기 | 바로가기 | 바로가기 | |||||||||||||
| ○ | ○ | Proceedings Paper | Remote Monitoring Systems of Unsafe Software Execution using QR Code-based Power Consumption Profile for IoT Edge Devices | If an error occurs in a system where several edges are gathered and operated together, the error may be transferred to other edges or the entire system may be down. Therefore, it is important to judge and control the errors of each edge in such a system, which puts a load on the embedded system of small edges. However, it is not easy to judge an error in an embedded system with limitations of performance. In such a system, we try to determine the state of the edge device using power consumption data and determine the error based on it. In this paper, we show that the server can determine errors using the power consumption data, and the data consumption allows the server to read data values through data communication using QR codes. In this architecture, the edge device only transmits power consumption data to reduce the load on the embedded system, and the gateway and server collect the data using QR codes communication. At the same time, the server interprets the received data to determine errors using various algorithms and controls the edge device. In this process, it is important to synchronize the edge device with the gateway and the server. Since the proposed structure uses a separate power meter and communication device, it solves the problem of not sending an appropriate message to the server when a communication error occurs at the previous edge. Also, the proposed model solves the overload problem that occurs when networks are used in various IoT devices using QR code that imaged data and light communication using a camera. After data is extracted and sorted from the QR code obtained by recognizing the camera of the intermediate server, the main server performs error determination through data analysis. The proposed architecture was implemented using 'chip-whisperer' to measure edges and data, as well as 'raspberry pi' to implement the server. As a result, the proposed architecture server showed successful data transmission and error determination, and it also showed very little additional load at the edge. | Kang, Myeongjin; Park, Daejin | Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu, South Korea | 57216440453; 55463943600 | audwls3158@gmail.com;boltanut@knu.ac.kr; | 2021 INTERNATIONAL CONFERENCE ON ELECTRONICS, INFORMATION, AND COMMUNICATION (ICEIC) | 0.73 | 2025-07-30 | 3 | 3 | Robust Execution; Embedded system; Error detection; QRcode; Data transmission | Data transmission; Embedded system; Error detection; QRcode; Robust Execution | Cameras; Electric power utilization; Embedded systems; Errors; Gateways (computer networks); Green computing; Internet of things; Network architecture; Additional loads; Communication device; Communication errors; Data-communication; Overload problems; Proposed architectures; Remote monitoring system; Software execution; Data communication systems | English | 2021 | 2021 | 10.1109/iceic51217.2021.9369725 | 바로가기 | 바로가기 | 바로가기 | ||||||||||||||
| ○ | ○ | Editorial Material | Reply to 'Sulfisoxazole does not inhibit the secretion of small extracellular vesicles' | Lee, Chan-Hyeong; Bae, Ju-Hyeon; Kim, Jong-In; Park, Ju-Mi; Choi, Eun-Ji; Baek, Moon-Chang | Kyungpook Natl Univ, Sch Med, Exosome Convergence Res Ctr ECRC, Dept Mol Med,CMRI, Daegu, South Korea | Kim, Jong/K-3445-2013 | 57189904697; 57221980462; 57865567700; 57221984091; 57221981039; 7006013097 | mcbaek@knu.ac.kr; | NATURE COMMUNICATIONS | 2041-1723 | 12 | 1 | 0.34 | 2025-07-30 | 3 | 3 | Bodily Secretions; Extracellular Vesicles; Receptors, Endothelin; Sulfisoxazole; 4 (4 methoxyphenyl) 2 (3,4 methylenedioxyphenyl) 4 oxo 3 (3,4,5 trimethoxybenzyl) 2 butenoic acid; cyclo(dextro tryptophyl dextro aspartylprolyl dextro valylleucyl); endothelin receptor; endothelin receptor A; sulfafurazole; unclassified drug; zibotentan; endothelin receptor; sulfafurazole; cytotoxicity; drug targeting; exosome; human; Letter; MDA-MB-231 cell line; small extracellular vesicle; bodily secretions | English | 2021 | 2021-02-12 | 10.1038/s41467-021-21075-w | 바로가기 | 바로가기 | 바로가기 | |||||||||||||
| ○ | ○ | Review | Report of the Korean Society of Infectious Diseases Roundtable Discussion on Responses to the Measles Outbreaks in Korea in 2019 | During the 2019 domestic measles outbreak in Korea, measles occurred in healthcare workers with two doses of the measles, mumps and rubella vaccine, and the strict application of the Occupational Safety and Health Act required medical institutions to identify healthcare workers' immunity to measles and vaccinate the susceptible pockets. In response to the frontline medical institutions' request to review the measles recommendations and guidelines, the Korean Society of Infectious Diseases held a roundtable discussion on the causes of measles outbreak, timing of vaccinations, antibody tests, and booster vaccinations for healthcare workers, and financial support from the government and municipality as well as response strategies against the outbreak in healthcare settings. In Korea, the seroprevalence of measles is decreasing in the vaccine-induced immunity group during the maintenance of measles elimination over several years. The susceptible group against measles is in their 20s and 30s, and this may be because of waning immunity rather than non-response considering Korea's vaccine policy. The risk of measles nosocomial infection from community increases as these susceptible pockets actively engage in medical institutions. Thus, data on the immunity of low seroprevalence group in Korea are needed, further discussion is needed on the booster vaccination based on the data. Especially, antibody testing and vaccination in healthcare workers may be necessary to prevent the spread of measles in medical insutitutions, and further discussion is needed regarding specific testing methods, and the timing and frequency of test and vaccination. | Seok, Hyeri; Park, Dae Won; Kim, Kwang Nam; Kim, Min Ja; Kim, Sung-Han; Kim, Jeong Yeon; Park, Su Eun; Park, Se Yoon; Eun, Byung Wook; Lee, Mi Suk; Chang, Hyun-Ha; Jung, Hyungul; Jeong, Hye Won; Jo, Soo-Nam; Chin, BumSik; Choi, Young Hwa; Choi, Eun Hwa; Choi, Hee Jung; Jee, Youngmee; Kim, Yang Soo; Soo, Yang | Korea Univ, Coll Med, Dept Internal Med, Div Infect Dis, Seoul, South Korea; Hallym Univ, Coll Med, Dept Pediat, Chunchon, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Infect Dis, 88 Olymp Ro 43-Gil, Seoul 05505, South Korea; Sahmyook Med Ctr, Dept Internal Med, Div Infect Dis, Seoul, South Korea; Pusan Natl Univ, Sch Med, Dept Pediat, Busan, South Korea; Soonchunhyang Univ, Coll Med, Soonchunhyang Univ Seoul Hosp, Dept Internal Med,Div Infect Dis, Seoul, South Korea; Eulji Univ, Coll Med, Dept Pediat, Daejeon, South Korea; Kyung Hee Univ, Sch Med, Kyung Hee Univ Hosp, Dept Internal Med, Seoul, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med,Div Infect Dis, Daegu, South Korea; Univ Geneva, Global Studies Inst, Geneva, Switzerland; Chungbuk Natl Univ, Coll Med, Dept Internal Med, Cheongju, South Korea; Gyeonggi Infect Dis Control Ctr, Suwon, South Korea; Natl Med Ctr, Dept Internal Med, Div Infect Dis, Seoul, South Korea; Ajou Univ, Sch Med, Dept Infect Dis, Suwon, South Korea; Seoul Natl Univ, Childrens Hosp, Coll Med, Div Pediat Infect Dis, Seoul, South Korea; Ewha Womans Univ, Coll Med, Dept Internal Med, Div Infect Dis, Seoul, South Korea; Inst Pasteur Korea, Seongnam, South Korea | ; Jeong, Hye/AET-1982-2022; Kim, Dong Ki/J-5389-2012; Park, SuEun/KHV-9023-2024; Jee, Youngmee/AGW-0164-2022; Kim, Ji Hwan/JKJ-3785-2023; Eun, Byungwook/NAZ-8644-2025; KIM, SUNG/ADF-8559-2022 | 56803460700; 55724785200; 8710955000; 57221707888; 55133790400; 55983699100; 36465325900; 55259986400; 12762260900; 55759244100; 7407521688; 57203635363; 13103042700; 56063170900; 7102658932; 27167708700; 24066557000; 57217262202; 57215907213; 56528813400 | yskim@amc.seoul.kr; | INFECTION AND CHEMOTHERAPY | INFECT CHEMOTHER | 2093-2340 | 2092-6448 | 53 | 3 | ESCI | INFECTIOUS DISEASES | 2021 | N/A | 0.25 | 2025-07-30 | 7 | 7 | Measles; Disease outbreaks; Prevention and control; Measles-mumps-rubella vaccine; Vaccines | HEALTH-CARE WORKERS; REPUBLIC-OF-KOREA; IMMUNOGLOBULIN-G; MMR-VACCINE; SEROPREVALENCE; ELIMINATION; ANTIBODIES; RUBELLA; MUMPS; IMMUNIZATION | Disease outbreaks; Measles; Measles-mumps-rubella vaccine; Prevention and control; Vaccines | measles vaccine; active immunization; controlled study; disease elimination; enzyme linked immunosorbent assay; epidemic; financial management; health care personnel; human; immunoassay; Korea; measles; passive immunization; pathogenesis; practice guideline; public policy; Review; seroprevalence; vaccination; vaccine immunogenicity | English | 2021 | 2021-09 | 10.3947/ic.2021.0084 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Article | Research on Intelligent Management System of Meteorological Archives Based on Big Data Framework | The era of big data, analysis, and artificial intelligence is a new trend in intelligent big data analysis. The present stage of the geoscience progress allows the Earth to be analyzed as an extremely dynamic structure of multiple elements, such as the hydrosphere, lithosphere, and atmosphere, interacting in and with others. To derive useful information from them, large quantities of observation and simulation data provided by numeric models need to be analyzed. Visualization is a critical feature of data analytics since it is a simple and swift way to evaluate the data and consider the specific aspects and mistakes of the dataset. A geographic information system (GIS), the most efficient meteorological data visualization software class, provides excellent capabilities for geospatial data manipulation. The processing architecture that can efficiently be used as a back-end for GIS by providing quick access to the data stored at remote storage nodes is described in this paper. Weather departments use various kinds of sensors for data collection such as temperature, humidity, etc. The number and speed of the sensors in each sensor complicate the data processing time. This paper seeks to provide a weather-temperature analysis big data forecast architecture based on the MapReduce algorithm. The suggested intelligent management system of meteorological archives based on big data (IMS-MABD) framework methodology could promote research and advancement of intelligent big data analysis, large data analytics, business intelligence, artificial intelligence, and data science. Intelligent management systems for meteorological archive systems based on large data frameworks could be used. Experimental findings show that the architecture created allows real-time data access and can support many simultaneous applications successfully with a performance of 98.1%. | Chen, Huawen; Xie, Jianyun; Wang, Sheng Jun; Ramanathan, Sakkaravarthi; Mutegeki, Ronald | Taizhou Meteorol Bur, Taizhou 318000, Zhejiang, Peoples R China; Taizhou Vocat & Tech Coll, Taizhou 318000, Zhejiang, Peoples R China; Taizhou Off Serv Ctr, Taizhou 318000, Zhejiang, Peoples R China; Vanier Coll, Comp Sci Dept, Montreal, PQ, Canada; Kyungpook Natl Univ, Sch Comp Sci & Engn, Daegu, South Korea | CHEN, SHUXIONG/HHN-3815-2022 | dongfang-gui@163.com;jianyunxie18@outlook.com;shengjunwang6@outlook.com;ramanats@vaniercollege.qc.ca;rmutegeki@knu.ac.kr; | ADVANCES IN DATA SCIENCE AND ADAPTIVE ANALYSIS | ADV DATA SCI ADAPT | 2424-922X | 2424-9238 | 13 | 03N04 | ESCI | MATHEMATICS, INTERDISCIPLINARY APPLICATIONS | 2021 | N/A | 2 | Meteorological; big data analytics; intelligent management system; geographic information systems; artificial intelligence | DATA ANALYTICS | English | 2021 | 2021-07 | 10.1142/s2424922x21420043 | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | ○ | Proceedings Paper | ReSGAN: Intracranial Hemorrhage Segmentation with Residuals of Synthetic Brain CT Scans | Intracranial hemorrhage (ICH) is a dangerous condition of bleeding within the skull that calls for rapid and precise diagnosis due to potentially fatal consequences. In this paper, we propose Residual Segmentation with Generative Adversarial Networks (ReSGAN) to accurately localize the hemorrhage from computerized tomography (CT) scans with a GAN-based model. Although convolutional neural networks have shown success in the ICH segmentation task, precise localization remains challenging due to in-balance and scarcity of labeled training data. Synthetic samples from generative models, and aligned templates as reference from brain atlas have been demonstrated to alleviate the issues. We consider synthetic templates as another candidate and solve the problem by directly applying a generative model to segmentation. Our ReSGAN learns a distribution of pseudo-normal brain CT scans, that through residuals, reliably delineates the hemorrhaging areas. We perform experiments on two datasets and compare our model against a well established baseline, that consistently shows significant improvements, therefore demonstrating the validity of our novel method. | Toikkanen, Miika; Kwon, Doyoung; Lee, Minho | Kyungpook Natl Univ, Dept Artificial Intelligence, Daegu, South Korea | 57286454000; 57212002790; 57191730119 | mholee@knu.ac.kr; | MEDICAL IMAGE COMPUTING AND COMPUTER ASSISTED INTERVENTION - MICCAI 2021, PT I | 0302-9743 | 1611-3349 | 12901 | 1.59 | 2025-07-30 | 5 | 10 | Semantic image synthesis; Segmentation; Brain; Intracranial hemorrhage; Non-contrast CT | Brain; Intracranial hemorrhage; Non-contrast CT; Segmentation; Semantic image synthesis | Computerized tomography; Convolutional neural networks; Diagnosis; Medical imaging; Semantic Segmentation; Semantics; Bleedings; Computerized tomography scan; Condition; Generative model; Images synthesis; Intracranial hemorrhages; Non-contrast computerized tomography; Segmentation; Semantic image synthesis; Semantic images; Generative adversarial networks | English | 2021 | 2021 | 10.1007/978-3-030-87193-2_38 | 바로가기 | 바로가기 | 바로가기 |
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