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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | Meeting Abstract | The Impacts of Skeletal Muscle Mass and Quality on Kidney Recovery of Patients with AKI Receiving Continuous Renal Replacement Therapy | Park, Jae Yoon; Paek, Jin hyuk; Jung, Jiyun; Lim, Jeong-Hoon; Kim, Yong Chul; Ban, Tae Hyun; Kim, Kipyo; Kim, Hyosang; Park, Woo Yeong | Dongguk Univ, Ilsan Hosp, Goyang, Gyeonggi Do, South Korea; Keimyung Univ, Dongsan Med Ctr, Daegu, South Korea; Kyungpook Natl Univ Hosp, Daegu, South Korea; Seoul Natl Univ Hosp, Seoul, South Korea; Catholic Univ Korea, Sch Med, Seoul, South Korea; Inha Univ, Sch Med, Incheon, South Korea; Asan Med Ctr, Seoul, South Korea | JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | J AM SOC NEPHROL | 1046-6673 | 1533-3450 | 34 | 11 | SCIE | UROLOGY & NEPHROLOGY | 2023 | 10.3 | 4.4 | 0 | English | 2023 | 2023-11 | 바로가기 | 바로가기 | ||||||||||||||||
| ○ | Meeting Abstract | ALCOHOL CONSUMPTION ACCELERATES HEPATIC MICROPLASTIC ACCUMULATION VIA IMPAIRED INTESTINAL MUCOSAL BARRIER | Baek, Su-Min; Kim, Tae-Un; Yim, Jae-Hyuk; Kim, Woo Jun; Park, Jin-Kyu | Kyungpook Natl Univ, Daegu, South Korea | Kim, Woo/D-2733-2015 | HEPATOLOGY | HEPATOLOGY | 0270-9139 | 1527-3350 | 78 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2023 | 13 | 4.5 | 0 | English | 2023 | 2023-10 | 바로가기 | 바로가기 | ||||||||||||||||
| ○ | Meeting Abstract | ALPHA-1 ANTITRYPSIN/ PROTEINASE 3 IMBALANCE EXERTS PROTEOLYTIC REGULATION ON INTERLEUKIN-32 GAMMA TO PROMOTE NONALCOHOLIC STEATOHEPATITIS | Park, JeongSu; Lee, Jin; Wang, Feng; Ma, Hwan; Lee, Yong-Sun; Lee, SangKyu; Yang, Yoon Mee; Yoo, Hwan-Soo; Han, Sang-Bae; Kim, Bumseok; Hong, Jin Tae; Roh, Yoon-Seok | Chungbuk Natl Univ, Cheongju, South Korea; Univ Calif San Diego, La Jolla, CA USA; Natl Inst Food & Drug Safety Evaluat, Cheongju, South Korea; Kyungpook Natl Univ, Daegu, South Korea; Kangwon Natl Univ, Chunchon, South Korea; Jeonbuk Natl Univ, Biosafety Res Inst, Iksan 54596, South Korea; Jeonbuk Natl Univ, Coll Vet Med, Iksan 54596, South Korea | Yoo, Hwan/N-4449-2018; Kim, Soo-Yeon/ADR-9663-2022; Yang, YoonMee/NQF-2987-2025 | HEPATOLOGY | HEPATOLOGY | 0270-9139 | 1527-3350 | 78 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2023 | 13 | 4.5 | 0 | English | 2023 | 2023-10 | 바로가기 | 바로가기 | ||||||||||||||||
| ○ | Meeting Abstract | AN ARTIFICIAL INTELLIGENCE MODEL FOR PREDICTION OF HEPATOCELLULAR CARCINOMA DEVELOPMENT AFTER ORAL ANTIVIRAL THERAPY IN PATIENTS WITH CHRONIC HEPATITIS C☆ | Lee, Yu Rim; Woo, Hyun Young; Park, Jung Gil; Kang, Min Kyu; Song, Jeongeun; Kuk, Jang Byoung; Kweon, Young-Oh; Tak, Won Young; Jang, Se Young; Park, Soo Young; Lee, Chang-Hyeong; Kim, Byung Seok; Hwang, Jaeseok; Chung, Woo Jin; Heo, Jeong; Hur, Keun | Kyungpook Natl Univ, Sch Med, Daegu, South Korea; Pusan Natl Univ, Busan, South Korea; Yeungnam Univ, Coll Med, Gyongsan, South Korea; Daegu Catholic Univ, Sch Med, Gyongsan, South Korea; Keimyung Univ, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Daegu, South Korea; Kyungpook Natl Univ, Coll Med, Daegu, South Korea; Keimyung Univ, Daegu, South Korea; Pusan Natl Univ, Dept Internal Med, Coll Med, Busan, South Korea | Kim, Seul Kee/A-6076-2015; Heo, Jeong/MHQ-1390-2025; Hur, Keun/G-9513-2011; Park, Jung/AAK-5167-2020; Kang, Min/U-8050-2018 | HEPATOLOGY | HEPATOLOGY | 0270-9139 | 1527-3350 | 78 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2023 | 13 | 4.5 | 0 | English | 2023 | 2023-10 | 바로가기 | 바로가기 | ||||||||||||||||
| ○ | Meeting Abstract | ATTENUATED LIVER TUMORIGENESIS IN FEMALE MICE IS ATTRIBUTED TO CONSERVED POLA1 EXPRESSION BY SMP30 | Baek, Su-Min; Park, Jin-Kyu | Kyungpook Natl Univ, Daegu, South Korea | HEPATOLOGY | HEPATOLOGY | 0270-9139 | 1527-3350 | 78 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2023 | 13 | 4.5 | 0 | English | 2023 | 2023-10 | 바로가기 | 바로가기 | |||||||||||||||||
| ○ | Meeting Abstract | DECREASED RISK OF HEPATOCELLULAR CARCINOMA IN PATIENTS WITH CHRONIC HEPATITIS B TREATED WITH BESIFOVIR | Yim, Hyung Joon; Kang, Seong Hee; Jung, Young Kul; Ahn, Sang Hoon; Kim, Won; Yang, Jin Mo; Jang, Jae Young; Cho, Yong Kyun; Kim, Yoon Jun; Kim, Dong Joon; Kweon, Young-Oh; Hong, Gun Young; Sohn, Joo Hyun; Lee, Jin-Woo; Park, Sung Jae; Young, Yim Sun; Shin, Seung Kak; Kim, Ji Hoon; Seo, Yeon Seok; Park, Jin Kyung; Um, Soonho | Korea Univ, Ansan Hosp, Ansan, South Korea; Severance Hosp, Seoul, South Korea; Seoul Natl Univ, Seoul, South Korea; Catholic Univ Korea, Seoul, South Korea; Soonchunhyang Univ, Coll Med, Asan, South Korea; Sungkyunkwan Univ, Sch Med, Seoul, South Korea; Seoul Natl Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Seoul Natl Univ, Coll Med, Liver Res Inst, Seoul, South Korea; Hallym Univ, Inst Liver & Digest Dis, Coll Med, Chunchon 24252, South Korea; Kyungpook Natl Univ, Coll Med, Daegu, South Korea; Kwangju Christian Hosp, Kwangju, South Korea; Hanyang Univ, Coll Med, Seoul, South Korea; Inha Univ, Incheon, South Korea; Inje Univ, Coll Med, Gimhae, South Korea; Korea Univ Hosp, Seoul, South Korea; Gachon Univ, Gil Med Ctr, Incheon, South Korea; Korea Univ, Korea Univ Anam Hosp, Coll Med, Seoul, South Korea; Ildong Pharmaceut Co, Seoul, South Korea; Korea Univ, Coll Med, Seoul, South Korea | Kim, Young/T-8521-2019; Kim, Eun Young/JCE-3602-2023; Kim, Ji/AAN-5655-2021; Kim, Won/H-6940-2019; Kim, Yoon/J-2746-2012 | HEPATOLOGY | HEPATOLOGY | 0270-9139 | 1527-3350 | 78 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2023 | 13 | 4.5 | 0 | English | 2023 | 2023-10 | 바로가기 | 바로가기 | ||||||||||||||||
| ○ | Meeting Abstract | EFFICACY AND SAFETY OF TENOFOVIR ALAFENAMIDE ( TAF) AT 2 YEARS IN CHILDREN AND ADOLESCENTS WITH CHRONIC HEPATITIS B ( CHB) | Schwarz, Kathleen B.; Bezerra, Jorge A.; Choe, Byung Ho; Lin, Chuan-Hao; Abramov, Frida; Wang, Hongyuan; Liu, Yang; Flaherty, John F.; Pacurar, Daniela; Kim, Kyung Mo; Khaertynova, Ilsiyar; Shalimar; Wu, Jia-Feng; Tandon, Manish; Rosenthal, Philip; Morozov, Viacheslav; Sokal, Etienne M.; Chang, Mei Hwei | Univ Calif San Diego, Rady Childrens Hosp San Diego, San Diego, CA 92103 USA; Univ Texas Southwestern Med Ctr, Dallas, TX USA; Kyungpook Natl Univ, Sch Med, Daegu, South Korea; Kyungpook Natl Univ Childrens Hosp, Daegu, South Korea; Childrens Hosp Los Angeles, Los Angeles, CA USA; Gilead Sci Inc, Foster City, CA USA; Carol Davila Univ Med & Pharm, Bucharest, Romania; Univ Ulsan, Asan Med Ctr, Childrens Hosp, Seoul, South Korea; Kazan State Med Univ, Kazan, Russia; All India Inst Med Sci, Delhi, India; Natl Taiwan Univ Hosp, Taipei, Taiwan; MV Hosp & Res Ctr, Lucknow, Uttar Pradesh, India; Univ Calif San Francisco, San Francisco, CA 94143 USA; Hepatolog Med Co, Samara, Russia; Clin Univ St Luc, Brussels, Belgium; Natl Taiwan Univ, Taipei, Taiwan; Children Hosp, Taipei, Taiwan | Wu, Jiafeng/KZU-6709-2024; Pacurar, Daniela/IYS-1131-2023; Choe, Byung-Ho/KSM-6251-2024; Lin, Chuan-Hao/AAH-6563-2019; wang, hongyuan/JWP-2279-2024 | HEPATOLOGY | HEPATOLOGY | 0270-9139 | 1527-3350 | 78 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2023 | 13 | 4.5 | 3 | English | 2023 | 2023-10 | 바로가기 | 바로가기 | ||||||||||||||||
| ○ | Meeting Abstract | HCC PREDICTION MODELS EFFECTIVELY ASSESS THE RISK OF HCC IN CHRONIC HEPATITIS C PATIENTS WITHOUT ADVANCED FIBROSIS AFTER ORAL ANTIVIRAL THERAPY: A MULTICENTER STUDY | Lee, Yu Rim; Woo, Hyun Young; Park, Jung Gil; Kang, Min Kyu; Song, Jeongeun; Jang, Byoung-Kuk; Kweon, Young-Oh; Tak, Won Young; Jang, Se Young; Park, Soo Young; Hur, Keun; Lee, Chang-Hyeong; Kim, Byung Seok; Hwang, Jaeseok; Chung, Woo Jin; Heo, Jeong; Heo, Nae-Yun; Park, Seung Ha; Yoon, Junsik; Baek, Yang Hyun | Kyungpook Natl Univ, Sch Med, Daegu, South Korea; Pusan Natl Univ, Busan, South Korea; Yeungnam Univ, Coll Med, Gyongsan, South Korea; Daegu Catholic Univ, Sch Med, Daegu, South Korea; Keimyung Univ, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Daegu, South Korea; Kyungpook Natl Univ, Coll Med, Daegu, South Korea; Keimyung Univ, Daegu, South Korea; Pusan Natl Univ, Dept Internal Med, Coll Med, Busan, South Korea; Inje Univ, Haeundae Paik Hosp, Gimhae, South Korea; Busan Paik Hosp, Busan, South Korea; Dong A Univ, Coll Med, Busan, South Korea | Heo, Nae-Yun/LUY-9667-2024; Heo, Jeong/MHQ-1390-2025; Kim, Seul Kee/A-6076-2015; Park, Jung/AAK-5167-2020; Kang, Min/U-8050-2018; Hur, Keun/G-9513-2011 | HEPATOLOGY | HEPATOLOGY | 0270-9139 | 1527-3350 | 78 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2023 | 13 | 4.5 | 0 | English | 2023 | 2023-10 | 바로가기 | 바로가기 | ||||||||||||||||
| ○ | Meeting Abstract | INITIAL EXPLORATION OF HEPATITIS B SURFACE ANTIGEN ( HBsAg) BLIPS FOLLOWING BEPIROVIRSEN TREATMENT: A POST HOC ANALYSIS OF THE B- CLEAR STUDY | Lim, Seng Gee; Gadano, Adrian; Stepanova, Tatyana; Diaconescu, Gheorghe Iulian; Fujiyama, Shigetoshi; Heo, Jeong; Kim, Ju Hyun; Kweon, Young Oh; Rizzardini, Giuliano; Idriz, Nevin; Gankina, Natalia; Kurosaki, Masayuki; Mohamed, Rosmawati; Piratvisuth, Teerha; Yuen, Man-Fung; Cremer, Ji Won; Elston, Robert; Quinn, Geoff; Paff, Melanie; Bouquet, Jerome; Lukic, Tamara; Theodore, Dickens | Natl Univ Hlth Syst, Singapore, Singapore; Hosp Italiano Buenos Aires, Buenos Aires, DF, Argentina; Modern Med Clin, Traralgon, Australia; Spitalul Clin Boli Infectioase Si Pneumoftiziol V, Craiova, Romania; Kumamoto Shinto Gen Hosp, Kumamoto, Japan; Pusan Natl Univ, Dept Internal Med, Coll Med, Busan, South Korea; Pusan Natl Univ Hosp, Biomed Res Inst, Busan, South Korea; Gachon Univ, Gil Med Ctr, Incheon, South Korea; Kyungpook Natl Univ, Sch Med, Daegu, South Korea; Asst Fatebenefratelli Sacco, Milan, Italy; Univ Med & Hosp Act Treatment Sofiamed, Sofia, Bulgaria; Krasnojarsk Reg Ctr AIDS Prevent, Krasnoyarsk, Russia; Musashino Red Cross Hosp, Tokyo, Japan; Univ Malaya, Med Ctr, Pusat Perubatan Univ Malaya, Kuala Lumpur, Malaysia; Nkc Inst Gastroenterol & Hepatol, Songkhla, Thailand; Queen Mary Hosp, Li Ka Shing Fac Med, Sch Clin Med, Dept Med, Hong Kong, Peoples R China; Univ Hong Kong, State Key Lab Liver Res, Hong Kong, Peoples R China; GSK, Durham, NC USA; GSK, Stevenage, Herts, England; GSK, Collegeville, PA USA; GSK, San Francisco, CA USA; GSK, Dubai, U Arab Emirates | LIM, Seng/AAD-9040-2020; Yuen, Richard Man Fung/C-4466-2009; Heo, Jeong/MHQ-1390-2025 | HEPATOLOGY | HEPATOLOGY | 0270-9139 | 1527-3350 | 78 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2023 | 13 | 4.5 | 0 | English | 2023 | 2023-10 | 바로가기 | 바로가기 | ||||||||||||||||
| ○ | Meeting Abstract | LONG- TERM ACCUMULATIONS OF POLYSTYRENE NANOPLASTICS SPECIFICALLY ACTIVATE HEPATIC STELLATE CELLS | Yim, Jae-Hyuk; Baek, Su-Min; Kim, Tae-Un; Kim, Woo Jun; Park, Jin-Kyu | Kyungpook Natl Univ, Daegu, South Korea | Kim, Woo/D-2733-2015 | HEPATOLOGY | HEPATOLOGY | 0270-9139 | 1527-3350 | 78 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2023 | 13 | 4.5 | 0 | English | 2023 | 2023-10 | 바로가기 | 바로가기 | ||||||||||||||||
| ○ | ○ | Article | Outcome of untreated low-level viremia versus antiviral therapy-induced or spontaneous undetectable HBV-DNA in compensated cirrhosis | Background: Comparative outcomes of HBV-infected compensated cirrhosis with low-level viremia (LLV) versus maintained virological response (MVR) are unclear. We conducted a large, multiethnic, multicenter study to examine the natural history of LLV versus MVR in compensated cirrhosis.Patients and Methods: We enrolled patients with HBV-infected compensated cirrhosis (n = 2316) from 19 hospitals in South Korea, Singapore, and Japan. We defined the LLV group as untreated patients with =1 detectable serum HBV-DNA (20-2000 IU/mL), Spontaneous-MVR group as untreated patients with spontaneously achieved MVR, and antiviral therapy (AVT)MVR group as patients achieving AVT-induced MVR. Study end points were HCC or hepatic decompensation.Results: The annual HCC incidence was 2.7/100 person-years (PYs), 2.6/ 100 PYs, and 3.3/100 PYs for LLV (n = 742), Spontaneous-MVR (n = 333), and AVT-MVR (n = 1241) groups, respectively (p = 0.81 between LLV vs. Spontaneous-MVR groups and p = 0.37 between LLV vs. AVT-MVR groups). Similarly, the annual decompensation incidence was 1.6/100 PYs, 1.9/100 PYs, and 1.6/100 PYs for LLV, Spontaneous-MVR, and AVT-MVR groups, respectively (p = 0.40 between LLV vs. Spontaneous-MVR groups and p = 0.83 between LLV vs. AVT-MVR groups). Multivariable analyses determined that HCC and decompensation risks in the LLV group were comparable to those with Spontaneous-MVR and AVT-MVR groups (all p > 0.05). Propensity score matching also reproduced similar results for HCC and decompensation risks (all p > 0.05 between LLV vs. Spontaneous-MVR groups and between LLV vs. AVT-MVR groups).Conclusions: Untreated LLV in HBV-infected compensated cirrhosis is not associated with increased risk of disease progression compared with Spontaneous-MVR and AVT-MVR. These data have important implications for practice and further research. | Huang, Daniel Q. Q.; Tamaki, Nobuharu; Lee, Hyung Woong; Park, Soo Young; Lee, Yu Rim; Lee, Hye Won; Lim, Seng Gee; Lim, Tae Seop; Kurosaki, Masayuki; Marusawa, Hiroyuki; Mashiba, Toshie; Kondo, Masahiko; Uchida, Yasushi; Kobashi, Haruhiko; Furuta, Koichiro; Izumi, Namiki; Kim, Beom Kyung; Sinn, Dong Hyun | Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore, Singapore; Natl Univ Singapore Hosp, Div Gastroenterol & Hepatol, Singapore, Singapore; Musashino Red Cross Hosp, Dept Gastroenterol & Hepatol, Tokyo, Japan; Yonsei Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Osaka Red Cross Hosp, Dept Gastroenterol & Hepatol, Osaka, Japan; Matsuyama Red Cross Hosp, Ctr Liver Biliary Pancreat Dis, Matsuyama, Ehime, Japan; Japanese Red Cross Otsu Hosp, Dept Gastroenterol, Otsu, Shiga, Japan; Matsue Red Cross Hosp, Dept Gastroenterol, Matsue, Shimane, Japan; Japanese Red Cross Okayama Hosp, Dept Gastroenterol, Okayama, Okayama, Japan; Masuda Red Cross Hosp, Dept Gastroenterol, Masuda, Shimane, Japan; Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Med, Seoul, South Korea; Yonsei Univ, Coll Med, Dept Internal Med, 50-1 Yonsei Ro, Seoul 03722, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Med, 81 Irwon Ro, Seoul 06351, South Korea | LIM, Seng/AAD-9040-2020; Lee, YuRim/ITU-1407-2023; Lee, Hye/D-9081-2016; Sinn, Dong/JAC-4247-2023; Huang, Daniel/LSJ-9214-2024; Kim, Kyung/I-5501-2015 | 57211508470; 36197581200; 57349302900; 57191674344; 57194094753; 57200110315; 57269602500; 56518959700; 35308923600; 6701365971; 6602815620; 36882270800; 7401607120; 7003583870; 57698134000; 7102192003; 35302925200; 23493891100 | daniel_huang@nus.edu.sg;nobuharu.tamaki@gmail.com;psyoung0419@gmail.com;kurosaki@musashino.jrc.or.jp;h.marusawa@osaka-med.jrc.or.jp;matoshi@matsuyama.jrc.or.jp;Masachan44@gmail.com;laboratory@matsue.jrc.or.jp;kobashi0584@gmail.com;furuta-k@masuda.jrc.or.jp;izumi012@musashino.jrc.or.jp;beomkkim@yuhs.ac;sinndhn@hanmail.net; | HEPATOLOGY | HEPATOLOGY | 0270-9139 | 1527-3350 | 77 | 5 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2023 | 13 | 4.5 | 0.98 | 2025-06-25 | 9 | 11 | CHRONIC HEPATITIS-B; HEPATOCELLULAR-CARCINOMA RISK; CORE-RELATED ANTIGEN; SURFACE-ANTIGEN; VIRUS DNA; INTEGRATION; SYSTEM | Antiviral Agents; Carcinoma, Hepatocellular; DNA, Viral; Hepatitis B virus; Humans; Liver Cirrhosis; Liver Neoplasms; Viremia; alanine aminotransferase; albumin; antivirus agent; aspartate aminotransferase; beta adrenergic receptor blocking agent; bilirubin; hepatitis B(e) antigen; hydroxymethylglutaryl coenzyme A reductase inhibitor; antivirus agent; virus DNA; adult; albumin blood level; anamnesis; antiviral therapy; Article; bilirubin blood level; Child Pugh score; compensated liver cirrhosis; controlled study; decompensated liver cirrhosis; diabetes mellitus; female; Fibrosis-4 Index; follow up; hepatitis B; human; human tissue; Japan; liver cell carcinoma; major clinical study; male; multicenter study; nonhuman; nuclear magnetic resonance imaging; outcome assessment; platelet count; propensity score; Singapore; South Korea; virus detection; x-ray computed tomography; clinical trial; genetics; Hepatitis B virus; liver cell carcinoma; liver cirrhosis; liver tumor; viremia | English | 2023 | 2023-05 | 10.1097/hep.0000000000000037 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Pharmacogenomic profiling reveals molecular features of chemotherapy resistance in IDH wild-type primary glioblastoma | Background Although temozolomide (TMZ) has been used as a standard adjuvant chemotherapeutic agent for primary glioblastoma (GBM), treating isocitrate dehydrogenase wild-type (IDH-wt) cases remains challenging due to intrinsic and acquired drug resistance. Therefore, elucidation of the molecular mechanisms of TMZ resistance is critical for its precision application.Methods We stratified 69 primary IDH-wt GBM patients into TMZ-resistant (n = 29) and sensitive (n = 40) groups, using TMZ screening of the corresponding patient-derived glioma stem-like cells (GSCs). Genomic and transcriptomic features were then examined to identify TMZ-associated molecular alterations. Subsequently, we developed a machine learning (ML) model to predict TMZ response from combined signatures. Moreover, TMZ response in multisector samples (52 tumor sectors from 18 cases) was evaluated to validate findings and investigate the impact of intra-tumoral heterogeneity on TMZ efficacy.Results In vitro TMZ sensitivity of patient-derived GSCs classified patients into groups with different survival outcomes (P = 1.12e-4 for progression-free survival (PFS) and 3.63e-4 for overall survival (OS)). Moreover, we found that elevated gene expression of EGR4, PAPPA, LRRC3, and ANXA3 was associated to intrinsic TMZ resistance. In addition, other features such as 5-aminolevulinic acid negative, mesenchymal/proneural expression subtypes, and hypermutation phenomena were prone to promote TMZ resistance. In contrast, concurrent copy-number-alteration in PTEN, EGFR, and CDKN2A/B was more frequent in TMZ-sensitive samples (Fisher's exact P = 0.0102), subsequently consolidated by multi-sector sequencing analyses. Integrating all features, we trained a ML tool to segregate TMZ-resistant and sensitive groups. Notably, our method segregated IDH-wt GBM patients from The Cancer Genome Atlas (TCGA) into two groups with divergent survival outcomes (P = 4.58e-4 for PFS and 3.66e-4 for OS). Furthermore, we showed a highly heterogeneous TMZ-response pattern within each GBM patient using in vitro TMZ screening and genomic characterization of multisector GSCs. Lastly, the prediction model that evaluates the TMZ efficacy for primary IDH-wt GBMs was developed into a webserver for public usage ().Conclusions We identified molecular characteristics associated to TMZ sensitivity, and illustrate the potential clinical value of a ML model trained from pharmacogenomic profiling of patient-derived GSC against IDH-wt GBMs. | Nam, Yoonhee; Koo, Harim; Yang, Yingxi; Shin, Sang; Zhu, Zhihan; Kim, Donggeon; Cho, Hee Jin; Mu, Quanhua; Choi, Seung Won; Sa, Jason K.; Seo, Yun Jee; Kim, Yejin; Lee, Kyoungmin; Oh, Jeong-Woo; Kwon, Yong-Jun; Park, Woong-Yang; Kong, Doo-Sik; Seol, Ho Jun; Lee, Jung-Il; Park, Chul-Kee; Lee, Hye Won; Yoon, Yeup; Wang, Jiguang | Hong Kong Univ Sci & Technol, Div Life Sci, Kowloon, Clear Water Bay, Hong Kong, Peoples R China; Hong Kong Univ Sci & Technol, State Key Lab Mol Neurosci, Kowloon, Clear Water Bay, Hong Kong, Peoples R China; Samsung Med Ctr, Inst Refractory Canc Res, Res Inst Future Med, Seoul, South Korea; Korea Univ, Dept Biomed Sci, Coll Med, Seoul, South Korea; Natl Canc Ctr, Grad Sch Canc Sci & Policy, Dept Canc Biomed Sci, Goyang, South Korea; Natl Canc Ctr, Res Inst & Hosp, Dept Clin Res, Goyang, South Korea; Hong Kong Univ Sci & Technol, Dept Chem & Biol Engn, Kowloon, Clear Water Bay, Hong Kong, Peoples R China; Kyungpook Natl Univ, Sch Convergence, Dept Biomed Convergence Sci & Technol, Daegu, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, Daegu, South Korea; Columbia Univ, Dept Syst Biol, Program Math Genom, New York, NY USA; Sungkyunkwan Univ, Samsung Adv Inst Hlth Sci & Technol, Dept Hlth Sci & Technol, Seoul, South Korea; Samsung Med Ctr, Samsung Genome Inst, Seoul, South Korea; Samsung Med Ctr, Dept Neurosurg, Seoul, South Korea; Sungkyunkwan Univ, Sch Med, Seoul, South Korea; Seoul Natl Univ, Coll Med, Dept Neurosurg, Seoul, South Korea; Seoul Natl Univ Hosp, Seoul, South Korea; Natl Canc Ctr, Ctr Urol Canc, Dept Urol, Goyang, South Korea; Samsung Med Ctr, Dept Urol, Seoul, South Korea; Sungkyunkwan Univ, Dept Biopharmaceut Convergence, Seoul, South Korea; InnoHK, Hong Kong Ctr Neurodegenerat Dis, Hong Kong, Peoples R China; HKUST Shenzhen Hong Kong Collaborat Innovat Res In, Shenzhen, Peoples R China | ; Mu, Quanhua/JKI-6568-2023; Park, Chul-Kee/J-5499-2012 | 57204287921; 57205687195; 57202532799; 56612613100; 58142794900; 57161227100; 55937716400; 55908407800; 57193525550; 56803454400; 56601550200; 57210413934; 57102132300; 57203033560; 35080680400; 7402229389; 10144905700; 57219637288; 57218516593; 56424318200; 57218088690; 7402126678; 53879035100 | nsproper@naver.com;benedict.yoon@samsung.com;jgwang@ust.hk; | GENOME MEDICINE | GENOME MED | 1756-994X | 15 | 1 | SCIE | GENETICS & HEREDITY | 2023 | 10.4 | 4.5 | 2.05 | 2025-06-25 | 13 | 13 | Machine learning; Glioblastoma; Temozolomide; Pharmacogenomics; Cancer genomics; Intra-tumoral heterogeneity | MALIGNANT GLIOMA; TEMOZOLOMIDE RESISTANCE; SELF-RENEWAL; EXPRESSION; MGMT; EVOLUTION; HETEROGENEITY; GROWTH; TUMORS | Cancer genomics; Glioblastoma; Intra-tumoral heterogeneity; Machine learning; Pharmacogenomics; Temozolomide | Brain Neoplasms; Drug Resistance, Neoplasm; Early Growth Response Transcription Factors; Glioblastoma; Glioma; Humans; Pharmacogenetics; Temozolomide; cyclin dependent kinase inhibitor 2A; cyclin dependent kinase inhibitor 2B; epidermal growth factor receptor; isocitrate dehydrogenase; phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase; pregnancy associated plasma protein A; temozolomide; early growth response factor; EGR4 protein, human; temozolomide; adult; aged; ANXA3 gene; Article; cancer chemotherapy; cell heterogeneity; cohort analysis; controlled study; copy number variation; drug efficacy; drug sensitivity; EGR4 gene; female; gene; gene expression; gene expression level; genomics; glioblastoma; glioma stem cell; human; human cell; in vitro study; LRRC3 gene; machine learning; major clinical study; male; overall survival; PAPPA gene; pharmacogenomics; progression free survival; RNA sequencing; somatic hypermutation; survival time; therapy resistance; transcriptomics; treatment response; whole exome sequencing; brain tumor; drug resistance; genetics; glioma; metabolism; pharmacogenetics | English | 2023 | 2023-03-13 | 10.1186/s13073-023-01165-8 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Meeting Abstract | PHASE 1b/2a STUDY OF HETEROLOGOUS ChAdOx1-HBV/MVA-HBV THERAPEUTIC VACCINATION (VTP-300) COMBINED WITH LOW-DOSE NIVOLUMAB (LDN) IN VIRALLY-SUPPRESSED PATIENTS WITH CHB ON NUCLEOS(T)IDE ANALOGUES | Lim, Young-Suk; Evans, Tom; Barnes, Eleanor; Mehta, Reena; Bussey, Louise; Anderson, Katie; Vardeu, Antonella; Brown, Anthony; Chen, Chi-Yi; Chuang, Wan-Long; Lo, Gin-Ho; Tak, Won Young; Tseng, Kuo-Chih | Univ Ulsan, Dept Gastroenterol, Asan Med Ctr, Coll Med, Seoul, South Korea; Univ Ulsan, Ctr Liver, Asan Med Ctr, Coll Med, Seoul, South Korea; Vaccitech, Clin Operat, Oxford, England; Univ Oxford, Natl Inst Hlth Res, Biomed Res Ctr, Oxford, England; Univ Oxford, Nuffield Dept Med, Oxford, England; Vaccitech Plc, Clin Operat, Oxford, England; Vaccitech Plc, Immunol Res, Oxford, England; Vaccitech, Res, Oxford, England; Univ Oxford, Peter Medawar Bldg Pathogen Res, Oxford, England; Chia Yi Christian Hosp, Chiayi, Taiwan; Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Hepatobiliary Sect, Dept Internal Med, Kaohsiung, Taiwan; E Da Hosp, Kaohsiung, Taiwan; Kyungpook Natl Univ, Sch Med, Daegu, South Korea; Buddhist Tzu Chi Med Fdn, Dalin Tzu Chi Hosp, Chiayi, Taiwan; Buddhist Tzu Chi Med Fdn, Dalin Tzu Chi Hosp, Dept Internal Med, Chiayi, Taiwan | Mehta, Reena/LFU-3952-2024; Lim, Young-Suk/AFQ-5165-2022; Chuang, Wan-Long/C-9536-2009 | HEPATOLOGY | HEPATOLOGY | 0270-9139 | 1527-3350 | 77 | 5 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2023 | 13 | 4.5 | 0 | English | 2023 | 2023-05 | 바로가기 | 바로가기 | |||||||||||||||
| ○ | Meeting Abstract | PROPOSAL OF A NOVEL SEROLOGICAL ALGORITHM COMBINING A FIBROSIS INDEX BASED ON FOUR AND SERUM MAC-2 BINDING PROTEIN GLYCOSYLATION ISOMER FOR ADVANCED FIBROSIS IN NON-ALCOHOLIC FATTY LIVER DISEASE | Kang, Yeowool; Baek, Yang Hyun; Moon, Sang Yi; Jun, Dae Won; Jang, Se Young; Yoon, Ki Tae; Cho, Young Youn; Jo, Hoon Gil | Dong A Univ, Busan, South Korea; Dong A Univ, Coll Med, Busan, South Korea; Hanyang Univ, Coll Med, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Daegu, South Korea; Pusan Natl Univ Hosp, Busan, South Korea; Chung Ang Univ Hosp, Seoul, South Korea; Wonkwang Univ Coll Med & Hosp, Iksan, South Korea | Jun, Dae Won/O-4529-2017 | HEPATOLOGY | HEPATOLOGY | 0270-9139 | 1527-3350 | 78 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2023 | 13 | 4.5 | 0 | English | 2023 | 2023-10 | 바로가기 | 바로가기 | ||||||||||||||||
| ○ | Meeting Abstract | PROTON PUMP INHIBITOR TREATMENT IS ASSOCIATED WITH A HIGHER MORTALITY IN CIRRHOTIC PATIENTS: A MULTICENTER STUDY | Yoon, Junsik; Hong, Ji Hoon; Park, Soo Young; Kim, Seung Up; Kim, Hwi Young; Kim, Ju Yeon; Hur, Moon Haeng; Park, Min Kyung; Bin Lee, Yun; Lee, Han Ah; Kim, Gi-Ae; Sinn, Dong Hyun; Park, Sung Jae; Lee, Youn-Jae; Kim, Yoon Jun; Yoon, Jung-Hwan; Lee, Jeong-Hoon | Inje Univ, Coll Med, Gimhae, South Korea; Seoul Natl Univ, Coll Med, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Daegu, South Korea; Yonsei Univ, Coll Med, Seoul, South Korea; Ewha Womans Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Seoul Natl Univ Hosp, Seoul, South Korea; Kyung Hee Univ, Sch Med, Seoul, South Korea; Samsung Med Ctr, Seoul, South Korea; Seoul Natl Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Seoul Natl Univ, Liver Res Inst, Coll Med, Seoul, South Korea | Kim, Joo/X-7562-2019; Sinn, Dong/JAC-4247-2023; Yoon, Jung/J-5563-2012; Lee, Dong-Hyeon/AAM-3893-2021; Kim, Yoon/J-2746-2012; Kim, Sun/L-4239-2013; Lee, Yoon Jae/HGE-5712-2022; KIM, BYOUNG HYUCK/IRZ-5874-2023; Kim, Gi-Ae/AAZ-2547-2021 | HEPATOLOGY | HEPATOLOGY | 0270-9139 | 1527-3350 | 78 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2023 | 13 | 4.5 | 0 | English | 2023 | 2023-10 | 바로가기 | 바로가기 |
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