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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Evaluation of different erosion-entrainment models in debris-flow simulation | Debris flow generated by landslides due to intense rainfall can cause extensive damage to residential areas. To predict and prevent the severity of such damage, several numerical models have been developed. However, there are limited studies regarding the entrainment and erosion effect of debris flow. This research aims to analyze several erosion-entrainment models for the selection of erosion-entrainment models in debris-flow analysis. The study focuses on landslides that occurred in the Raemian and Sindonga apartment basins in Mt. Umyeon, Republic of Korea, on July 27, 2011. The impact area, entrainment volume, maximum velocity, inundated depth, and erosion shape resulting from the debris-flow modeling were compared with field data. The simulation results of each erosion-entrainment model were assessed through the receiver operating characteristic method. | Lee, Seungjun; An, Hyunuk; Kim, Minseok; Lee, Giha; Shin, Hongjoon | Chungnam Natl Univ, Dept Agr & Rural Engn, Daejeon, South Korea; Korea Inst Geosci & Mineral Resources, Geol Hazards Div, Daejeon, South Korea; Kyungpook Natl Univ, Dept Adv Sci & Technol Convergence, Sangju, South Korea; Korea Hydro & Nucl Power Co LTD, Hydropower Res & Training Ctr, Gyeonggi Do, South Korea | 57654680300; 36639175600; 55686274700; 35069799400; 24178213000 | hyunuk@cnu.ac.kr;minseok_kim@kigam.re.kr; | LANDSLIDES | LANDSLIDES | 1612-510X | 1612-5118 | 19 | 9 | SCIE | ENGINEERING, GEOLOGICAL;GEOSCIENCES, MULTIDISCIPLINARY | 2022 | 6.7 | 6.7 | 1.34 | 2025-06-25 | 13 | 15 | Landslides; Debris flow; Erosion-entrainment; Mt; Umyeon | FLUIDIZED GRANULAR MASSES; RUNOUT; RECONSTRUCTION; CALIBRATION; AVALANCHES | Debris flow; Erosion–entrainment; Landslides; Mt. Umyeon | Mount Umyeon; Seoul [South Korea]; South Korea; Apartment houses; Debris; Landslides; Debris flow simulations; Debris flows; Entrainment effects; Erosion effects; Erosion–entrainment; Flow analysis; Intense rainfalls; Mt umyeon; Republic of Korea; Residential areas; damage; debris flow; entrainment; erosion; simulation; Erosion | English | 2022 | 2022-09 | 10.1007/s10346-022-01901-y | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | NUDT15 intermediate metabolisers are associated with lower loss of response in paediatric Crohn's disease patients treated by combination treatment with infliximab and azathioprine | Background NUDT15 polymorphisms are associated with leukopenia during treatment with thiopurines. However, data regarding its effect on treatment outcomes are scarce. Aims To investigate the outcomes between NUDT15 normal and intermediate metabolisers in paediatric patients with Crohn's disease (CD) treated with a combination therapy of infliximab (IFX) and azathioprine (AZA). Methods In this retrospective observational study, 143 patients categorised into the NUDT15 normal and intermediate metaboliser groups were compared based on clinical remission (CR), biochemical remission (BR), mucosal healing (MH) at 1 year treatment, IFX trough levels (TLs), antibodies to IFX (ATIs), 6-thioguanine nucleotide (6-TGN) levels, loss of response (LOR) and IFX durability. Results No significant differences were observed between the groups in CR, BR, MH at 1 year, whereas IFX TLs and ATIs and 6-TGN levels were comparable. However, LOR (6.5% vs 27.7%, P = 0.025) was significantly lower and IFX durability significantly higher (96.8% vs 80.4% P = 0.027) in the intermediate group. Multivariable Cox proportional hazard regression analysis showed that ATI positivity (hazard ratio (HR): 4.76, 95% CI: 2.25-10.07, P < 0.001) and the NUDT15 metaboliser group was associated with LOR (HR: 0.18, 95% CI: 0.04-0.76, P = 0.019). The Kaplan-Meier survival curves showed that the LOR-free survival rate was significantly lower in normal metabolisers (log-rank test P = 0.009). Conclusion NUDT15 intermediate metabolisers were associated with lower LOR in paediatric patients with CD treated with IFX and AZA combination therapy. This finding may partially explain the longer durability of IFX in Korean children than their counterparts in Western countries. | Kim, Eun Sil; Choi, Sujin; Choi, So Yoon; Park, Ji Hyung; Choe, Byung-Ho; Lee, Soo-Youn; Kim, Mi Jin; Choe, Yon Ho; Kang, Ben | Sungkyunkwan Univ, Samsung Med Ctr, Dept Pediat, Sch Med, 81 Irwon Ro, Seoul 06351, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pediat, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kosin Univ, Dept Pediat, Gospel Hosp, Coll Med, Busan, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Lab Med & Genet, Seoul, South Korea | Kim, Nam-Joong/J-2735-2012; Kim, Mi Jin/GXH-9639-2022; 康, 奔/JMQ-0812-2023; Lee, YuRim/ITU-1407-2023; Choe, Byung-Ho/KSM-6251-2024 | 57205500267; 57223972405; 57207282105; 57326465000; 57574977300; 7601413957; 56638815200; 21333712100; 57194823199 | i101016@skku.edu;benkang@knu.ac.kr; | ALIMENTARY PHARMACOLOGY & THERAPEUTICS | ALIMENT PHARM THER | 0269-2813 | 1365-2036 | 55 | 8 | SCIE | GASTROENTEROLOGY & HEPATOLOGY;PHARMACOLOGY & PHARMACY | 2022 | 7.6 | 6.7 | 0.33 | 2025-06-25 | 3 | 3 | Crohn's disease; infliximab; loss of response; NUDT15 | INFLAMMATORY-BOWEL-DISEASE; THERAPY; CHILDREN; IMMUNOMODULATOR; VARIANT | Crohn’s disease; infliximab; loss of response; NUDT15 | Azathioprine; Child; Crohn Disease; Gastrointestinal Agents; Humans; Infliximab; Treatment Outcome; azathioprine; infliximab; tioguanine; azathioprine; gastrointestinal agent; infliximab; adolescent; Article; biochemical remission; child; clinical outcome; clinical remission; controlled study; Crohn disease; disease activity; female; gene; genetic association; human; major clinical study; male; mucosal healing; NUDT15 gene; observational study; pediatrics; retrospective study; survival rate; treatment response; genetics; treatment outcome | English | 2022 | 2022-04 | 10.1111/apt.16769 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Physicochemical properties, antioxidant activities and microbial communities of Ethiopian honey wine, Tej | Ethiopian honey wine, Tej, is spontaneously fermented traditional alcoholic beverage, usually made from honey and "gesho" (Rhamnus prinoides). Till now, limited amount of information is available on the characterization of Tej. Thus, the aim of this paper is to reveal the microbiological diversity and physicochemical properties of Tej samples collected from different areas of Ethiopia. High-throughput sequencing, electrochemical and chromatographic techniques, and spectrophotometric methods were used to achieve these objectives. Although there was a statistical difference in the exact values of physicochemical properties between the collected Tej samples, the pH and titratable acidity values of the samples ranged from 2.8 to 3.8 and from 1.81 to 8.65 g/L, respectively. Similarly, the alcohol and sugar contents of the samples were in the range of 6.36-11.34 g/100 mL and from 0.37 to 31.6 g/L, respectively. Moreover, the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 3-ethylbenzothiazoline-6-sulfonic acid diammonium salt (ABTS) values of the samples were in the range of 37.9-81.0% and 27.4-73.1%, respectively. Furthermore, microbial community structure was predominated by a few fermentative microorganisms. Specifically, the bacterial community structure was dominated by the genera of Lactobacillus (53.15%) and Zymomonas (38.41%). Whereas, the fungal community structure was exclusively dominated by genus of Saccharomyces (99.66%). Additionally, Lactobacillus, Zymomonas and Saccharomyces were the detected core microbiome for the collected Tej samples. Both bacterial and fungal communities had shown no statistically significant differences in alpha diversity analysis based on the area of sample collection. However, the bacterial communities had a statically significant difference in Unweighted Unifrac beta diversity analysis. Generally, the observed shared physicochemical characteristic features and the dominance by certain group of microorganisms might be seen as a boon for the development of direct fermentation system to this traditional alcoholic beverage. | Fentie, Eskindir Getachew; Jeong, Minsoo; Emire, Shimelis Admassu; Demsash, Hundessa Dessalegn; Kim, Min A.; Jeon, Hwang-Ju; Lee, Sung-Eun; Tagele, Setu Bazie; Park, Yeong-Jun; Shin, Jae-Ho | Addis Ababa Sci & Technol Univ, Coll Biol & Chem Engn, Addis Ababa 16417, Ethiopia; Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea; Addis Ababa Univ, Sch Chem & Bioengn, Addis Ababa Inst Technol, POB 385,King George VI St, Addis Ababa 16417, Ethiopia; Natl Inst Korean Med Dev, Daegu 38540, South Korea | Jeon, Hwangju/JDW-9035-2023; Fentie, Eskindir/LIG-6089-2024; Tagele, Setu Bazie/IYJ-1959-2023; Kim, Jwa/AAH-9915-2021 | 57245844200; 57292954900; 36189913000; 57192308986; 56123031300; 56328792200; 55890041600; 57202007103; 56275800900; 57224125922 | jhshin@knu.ac.kr; | FOOD RESEARCH INTERNATIONAL | FOOD RES INT | 0963-9969 | 1873-7145 | 152 | SCIE | FOOD SCIENCE & TECHNOLOGY | 2022 | 8.1 | 6.7 | 1.14 | 2025-06-25 | 11 | 13 | Spontaneous fermentation; Physicochemical property; Antioxidant activity; Tej; Lactobacillus; Zymomonas; Saccharomyces | ACETIC-ACID BACTERIA; BOTTLED RED WINE; SACCHAROMYCES-CEREVISIAE; FERMENTATION; SPOILAGE; YEAST; TIME; PH | Antioxidant activity; Lactobacillus; Physicochemical property; Saccharomyces; Spontaneous fermentation; Tej; Zymomonas | Antioxidants; Ethiopia; Honey; Microbiota; Wine; Antioxidants; Bacteria; Fermentation; Spectrophotometry; Wine; antioxidant; Antioxidant activities; Bacterial community; Diversity analysis; Fungal community; Honey wines; Physicochemical property; Saccharomyces; Spontaneous fermentation; Tej; Zymomonas; Ethiopia; honey; microflora; wine; Physicochemical properties | English | 2022 | 2022-02 | 10.1016/j.foodres.2021.110765 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Pore-Scale Investigation of Dynamic Immiscible Displacement in Layered Media using Synchrotron X-ray Microtomography | Understanding the dynamics of immiscible fluid in a porous media is critical in many chemical and environmental engineering processes. However, the geological heterogeneity effect on multiphase flow behavior remains unclear. Here, the dynamics of immiscible fluid displacement and entrapment were experimentally demonstrated at pore-level using time-lapse synchrotron X-ray microtomography. A drainage-imbibition experiment was designed using an unconsolidated layered sand pack that comprised coarse sand and fine sand zones. There were significant differences between the two zones, with regard to the temporal variations in fluid saturation and morphological evolution of nonwetting fluid (oil) during imbibition. Highly connected oil clusters in the coarse zone broke up into many small fragments, whereas the cluster in the fine zone remained connected while spanning multiple pores. To further understand the impacts of pore size and connectivity on multiphase fluid dynamics, a new approach that tracks the temporal variation of immiscible fluid in individual pores was conducted. The surface area at the oil-water interface increased during imbibition, which is expected to facilitate mass transfer and surface interactions. Understanding immiscible fluid displacement in layered porous media at the pore-level could lead to more effective environmental remediation. | Kim, Minji; Kim, Kue-Young; Lim, Jae-Hong; Kim, Chan Yeong; Kim, Seob-Gu; Han, Gidon; Han, Weon Shik; Park, Eungyu | Korea Inst Geosci & Mineral Resources, Daejeon 34132, South Korea; Yonsei Univ, Dept Earth Syst Sci, Seoul 03722, South Korea; Pohang Accelerator Lab, Pohang 37673, South Korea; Kyungpook Natl Univ, Dept Geol, Daegu 41566, South Korea | Han, Weon Shik/KCY-0126-2024 | 59036772400; 15029920800; 36009996400; 57201732408; 57219902258; 57205646508; 57226420125; 23995577700 | kykim@kigam.re.kr; | ENVIRONMENTAL SCIENCE & TECHNOLOGY | ENVIRON SCI TECHNOL | 0013-936X | 1520-5851 | 56 | 1 | SCIE | ENGINEERING, ENVIRONMENTAL;ENVIRONMENTAL SCIENCES | 2022 | 11.4 | 6.7 | 0.48 | 2025-06-25 | 9 | 9 | immiscible fluid displacement; heterogeneity; pore-scale; synchrotron X-ray microcomputed tomography | SURFACTANT-ENHANCED SOLUBILIZATION; MULTIPHASE FLOW; POROUS-MEDIA; RELATIVE PERMEABILITY; CONTACT-ANGLE; CO2; FLUID; OIL; TOMOGRAPHY; RESERVOIRS | heterogeneity; immiscible fluid displacement; pore-scale; synchrotron X-ray microcomputed tomography | Environmental Restoration and Remediation; Geology; Porosity; Synchrotrons; X-Ray Microtomography; Computerized tomography; Mass transfer; Phase interfaces; Pore size; Porous materials; oil; water; Fluid displacement; Heterogeneity; Immiscible displacement; Immiscible fluid displacement; Immiscible fluids; Micro computed tomography (micro-CT); Pore scale; Synchrotron X-ray microcomputed tomography; Synchrotron X-ray microtomography; Temporal variation; connectivity; detection method; heterogeneity; immiscible fluid; multiphase flow; temporal variation; Article; controlled study; dynamics; fluid transport; liquid; micro-computed tomography; miscibility; particle size; pore size; pore volume; sand; surface area; synchrotron x ray microtomography; ecosystem restoration; geology; micro-computed tomography; porosity; synchrotron; Multiphase flow | English | 2022 | 2022-01-04 | 10.1021/acs.est.1c05557 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Transmural healing evaluated by magnetic resonance enterography in paediatric patients with Crohn's disease receiving maintenance treatment with biologics | Background The optimal treatment goal in Crohn's disease (CD) is endoscopic healing (EH). However, transmural healing (TH) facilitated by the development and increasing performance of magnetic resonance enterography (MRE) is emerging as a potential treatment goal. Aims To assess TH rates after 1 year of treatment by MRE and its relationship with EH in paediatric patients with CD receiving anti-tumour necrosis factor (TNF) agents, and to investigate factors associated with TH after 1 year of treatment. Methods This multi-centre, prospective, observational study included Korean paediatric patients with luminal CD diagnosed at age < 19 years who were naive to anti-TNF treatment. They simultaneously underwent ileocolonoscopy and MRE at baseline and after 1 year of treatment with biologics. Results We included 116 patients. At 1 year, EH and TH were achieved in 59.5% (69/116) and 38.8% (45/116) of the patients, respectively. Both EH and TH was observed in 35.3% (41/116), EH without TH in 24.1% (28/116), TH without EH in 3.4% (4/116), and neither EH nor TH in 37.1% (43/116). Moreover, 59.4% (41/69) of patients who achieved EH at 1 year exhibited TH, and 91.1% (41/45) of patients who achieved TH exhibited EH. Baseline MaRIA score was associated with TH according to a multivariate analysis (OR 0.97, 95% CI 0.95-0.99, p = 0.023). Conclusion TH is a more stringent goal than EH. Regular follow-up evaluation of transmural status, and efforts to achieve TH, may alter the natural course of CD in the era of treat-to-target. | Choi, So Yoon; Kim, Eun Sil; Jeon, Tae Yeon; Lee, Yoo Min; Lee, So Mi; Choe, Byung-Ho; Choe, Yon Ho; Kang, Ben | Kosin Univ, Coll Med, Gospel Hosp, Dept Pediat, Busan, South Korea; Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Dept Pediat, Seoul, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Radiol, Seoul, South Korea; Soonchunhyang Univ, Coll Med, Bucheon Hosp, Dept Pediat, Bucheon, South Korea; Kyungpook Natl Univ, Sch Med, Dept Radiol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pediat, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Pediat, Sch Med, 81 Irwon Ro, Seoul 06351, South Korea | ; Choe, Byung-Ho/KSM-6251-2024; Lee, Ji Min/ABE-7494-2021; 康, 奔/JMQ-0812-2023; Kim, Nam-Joong/J-2735-2012 | 57207282105; 57205500267; 17137114800; 55588928200; 56824903400; 57574977300; 21333712100; 57194823199 | i101016@skku.edu;benkang@knu.ac.kr; | ALIMENTARY PHARMACOLOGY & THERAPEUTICS | ALIMENT PHARM THER | 0269-2813 | 1365-2036 | 56 | 7 | SCIE | GASTROENTEROLOGY & HEPATOLOGY;PHARMACOLOGY & PHARMACY | 2022 | 7.6 | 6.7 | 0.44 | 2025-06-25 | 5 | 4 | INFLAMMATORY-BOWEL-DISEASE; CLINICAL REMISSION; MUCOSAL; THERAPY; INFLIXIMAB; CHILDREN; OUTCOMES; IMMUNOMODULATOR; CALPROTECTIN; DEFINITION | Adult; Biological Products; Child; Crohn Disease; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Prospective Studies; Severity of Illness Index; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha; Young Adult; biological product; tumor necrosis factor; tumor necrosis factor inhibitor; adult; child; clinical trial; Crohn disease; diagnostic imaging; human; multicenter study; nuclear magnetic resonance imaging; nuclear magnetic resonance spectroscopy; prospective study; severity of illness index; young adult | English | 2022 | 2022-10 | 10.1111/apt.17161 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | BAP1 phosphorylation-mediated Sp1 stabilization plays a critical role in cathepsin K inhibition-induced C-terminal p53-dependent Bax upregulation | Cathepsin K inhibitor (odanacatib; ODN) and cathepsin K knockdown (siRNA) enhance oxaliplatin-induced apoptosis through p53-dependent Bax upregulation. However, its underlying mechanisms remain unclear. In this study, we elucidated the mechanism behind enhancement of oxaliplatin-induced apoptosis by ODN. We also investigated the molecular mechanisms of ODN-induced Bax upregulation. Here, we demonstrated that ODNinduced Bax upregulation required p53, but it was independent of p53 transcriptional activity. Various mutants of the DNA-binding domain of p53 induced Bax upregulation in ODN-treated cells. p53 functional domain analysis showed that the C-terminal domain of p53 participates in the physical interaction and stabilization of Sp1, a major transcription factor of Bax. We screened a specific siRNA encoding 50 deubiquitinases and identified that BAP1 stabilizes Sp1. The knockdown or catalytic mutant form of BAP1 abolished the ODN-induced upregulation of Sp1 and Bax expression. Mechanistically, ODN induced BAP1 phosphorylation and enhanced Sp1BAP1 interaction, resulting in Sp1 ubiquitination and degradation. Interestingly, ODN-induced BAP1 phosphorylation and DNA damage were modulated by the production of mitochondrial reactive oxygen species (ROS). Mitochondrial ROS scavengers prevented DNA damage, BAP1-mediated Sp1 stabilization, and Bax upregulation by ODN. BAP1 downregulation by siRNA inhibited apoptosis induced by the combined treatment of ODN and oxaliplatin/etoposide. Therefore, Sp1 is a crucial transcription factor for ODN-induced Bax upregulation, and Sp1 stabilization is regulated by BAP1. | Seo, Seung Un; Woo, Seon Min; Lee, Seul Gi; Kim, Min Yeong; Lee, Hyun Shik; Choi, Yung Hyun; Kim, Sang Hyun; Chang, Young-Chae; Min, Kyoung-jin; Kwon, Taeg Kyu | Keimyung Univ, Sch Med, Dept Immunol, Daegu 42601, South Korea; Dong Eui Univ, Coll Korean Med, Dept Biochem, Pusan 47227, South Korea; Kyungpook Natl Univ, Coll Nat Sci, Sch Life Sci, Plus KNU Creat Biores Grp BK21, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pharmacol, Daegu 41944, South Korea; Catholic Univ Daegu, Res Inst Biomed Engn, Dept Med, Sch Med, Daegu 42472, South Korea; Daegu Gyeongbuk Med Innovat Fdn DGMIF, New Drug Dev Ctr, Daegu 41061, South Korea; Keimyung Univ, Ctr Forens Pharmaceut Sci, Daegu 42601, South Korea; Keimyung Univ, 1095 Dalgubeoldaero,Dalseo Gu, Daegu 42601, South Korea | 57195411399; 57199873466; 56995397800; 57196352735; 16316010200; 57211727369; 57210450420; 7501843107; 7201466928; 7202206057 | kwontk@dsmc.or.kr; | REDOX BIOLOGY | REDOX BIOL | 2213-2317 | 53 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY | 2022 | 11.4 | 6.8 | 0.99 | 2025-06-25 | 13 | 10 | Odanacatib; Bax; p53; Sp1; BAP1; Mitochondrial ROS | TUMOR-SUPPRESSOR P53; BINDING-PROTEINS; S100 FAMILY; DNA-DAMAGE; APOPTOSIS; PROTECTS; PROMOTER; TARGET; ATM | BAP1; Bax; Mitochondrial ROS; Odanacatib; p53; Sp1 | Apoptosis; bcl-2-Associated X Protein; Cathepsin K; Oxaliplatin; Phosphorylation; Reactive Oxygen Species; RNA, Small Interfering; Transcription Factors; Tumor Suppressor Protein p53; Up-Regulation; BAP1 protein; cathepsin K; cathepsin K inhibitor; deubiquitinase; etoposide; odanacatib; oxaliplatin; protein Bax; protein p53; reactive oxygen metabolite; small interfering RNA; transcription factor Sp1; unclassified drug; cathepsin K; protein Bax; protein p53; transcription factor; animal experiment; antiapoptosis; apoptosis; Article; carboxy terminal sequence; catalysis; controlled study; DNA binding; DNA damage; down regulation; gene knockdown; genetic transcription; human; human cell; mitochondrion; molecular mechanics; nonhuman; protein expression; protein function; protein phosphorylation; protein protein interaction; protein stability; upregulation; apoptosis; genetics; metabolism; phosphorylation; upregulation | English | 2022 | 2022-07 | 10.1016/j.redox.2022.102336 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Convexity of the Capacity of One-Bit Quantized Additive White Gaussian Noise Channels | In this study, the maximum error-free transmission rate of an additive white Gaussian noise channel with a symmetric analog-to-digital converter (ADC) was derived as a composite function of the binary entropy function, Gaussian Q-function, and the square root function, assuming that the composite function was convex on the set of all non-negative real numbers. However, because mathematically proving this convexity near zero is difficult, studies in this field have only presented numerical results for small values in the domain. Because the low-signal-to-noise (SNR) regime is considered to be a major application area for one-bit ADCs in wireless communication, deriving a concrete proof of the convexity of the composite function on small SNR values (non-negative values near zero) is important. Therefore, this study proposes a novel proof for convexity, which is satisfied for all non-negative values, based on the continuity of the involved functions. | Lee, Sungmin; Min, Moonsik | Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Elect Engn, Daegu 41566, South Korea | 57976218200; 55386299100 | msmin@knu.ac.kr; | MATHEMATICS | MATHEMATICS-BASEL | 2227-7390 | 10 | 22 | SCIE | MATHEMATICS | 2022 | 2.4 | 6.8 | 0.32 | 2025-06-25 | 2 | 2 | convexity; entropy; mutual information; channel capacity | MULTIUSER MIMO SYSTEMS; WAVE MASSIVE MIMO; UPLINK; COMMUNICATION; ADCS | channel capacity; convexity; entropy; mutual information | English | 2022 | 2022-11 | 10.3390/math10224343 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Deep Learning Activation Layer-Based Wall Quality Recognition Using Conv2D ResNet Exponential Transfer Learning Model | Crack detection is essential for observing structural health and guaranteeing structural safety. The manual crack and other damage detection process is time-consuming and subject to surveyors' biased judgments. The proposed Conv2D ResNet Exponential model for wall quality detection was trained with 5000 wall images, including various imperfections such as cracks, holes, efflorescence, damp patches, and spalls. The model was trained with initial weights to form the trained layers of the base model and was integrated with Xception, VGG19, DenseNet, and ResNet convolutional neural network (CNN) models to retrieve the general high-level features. A transfer deep-learning-based approach was implemented to create a custom layer of CNN models. The base model was combined with custom layers to estimate wall quality. Xception, VGG19, DenseNet, and ResNet models were fitted with different activation layers such as softplus, softsign, tanh, selu, elu, and exponential, along with transfer learning. The performance of Conv2D was evaluated using model loss, precision, accuracy, recall, and F-score measures. The model was validated by comparing the performances of Xception, VGG19, DenseNet, ResNet, and Conv2D ResNet Exponential. The experimental results show that the Conv2D ResNet model with an exponential activation layer outperforms it with an F-score value of 0.9978 and can potentially be a viable substitute for classifying various wall defects. | Kim, Bubryur; Natarajan, Yuvaraj; Munisamy, Shyamala Devi; Rajendran, Aruna; Sri Preethaa, K. R.; Lee, Dong-Eun; Wadhwa, Gitanjali | Kyungpook Natl Univ, Dept Robot & Smart Syst Engn, 80 Daehak ro, Daegu 41566, South Korea; KPR Inst Engn & Technol, Dept Comp Sci & Engn, Coimbatore 641407, India; Vel Tech Rangarajan Dr Sagunthala R&D Inst Sci & T, Chennai 600062, India; Kyungpook Natl Univ, Sch Architecture, Civil Environm & Energy Engn, 80 Daehak ro, Daegu 41566, South Korea | raj, yuva/GWV-2080-2022; Natarajan, Yuvaraj/GWV-2080-2022; Devi, Shyamala/AAS-7396-2021; Wadhwa, Girish/D-6886-2018; R, Aruna/JFS-2170-2023; Nandhini, Aruna/JFS-2170-2023 | 57198355299; 57204528689; 36688404200; 58509317500; 57214320928; 56605563300; 57219654131 | k.r.sripreethaa@kpriet.ac.in;dolee@knu.ac.kr; | MATHEMATICS | MATHEMATICS-BASEL | 2227-7390 | 10 | 23 | SCIE | MATHEMATICS | 2022 | 2.4 | 6.8 | 1.89 | 2025-06-25 | 8 | 13 | deep learning; Conv2D; activation layer; transfer learning; F-score | CRACK DETECTION; SURFACE; IMAGES; SIZE | activation layer; Conv2D; deep learning; F-score; transfer learning | English | 2022 | 2022-12 | 10.3390/math10234602 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Digital Image Correlation Compatible Mechanoluminescent Skin for Structural Health Monitoring | Monitoring structural health using mechanoluminescent (ML) effects is widely considered as a potential full-field and direct visualizing optical method with high spatial and temporal resolution and simple setup in a noncontact manner. The challenges and uncertainties in the mapping of ML field to effective strain field, however, tend to limit significant commercial ML applications for structural health monitoring systems. Here, however, quantification problems are resolved using the digital image correlation (DIC) method. Specifically, an image containing mechanically induced photon information is processed using a DIC algorithm to measure the strain field components, which enables the establishment of a calibration curve when the ML field is mapped onto the effective strain field using pixel level information. The results show a linear relationship between effective strain and ML intensity despite the plastic flow in ML skin. Furthermore, the calibration curve allows for easy conversion of ML field to effective-strain field at the crack-tip plastic zone of the alloy structure, retaining its spatial resolution. The compatibility of ML skin with the DIC algorithm not only enables the quantification of the ML effects of several organic/inorganic ML materials, but may also be useful in elucidating the fundamentals of the trap-controlled mechanism. | Shin, Ho Geun; Timilsina, Suman; Sohn, Kee-Sun; Kim, Ji Sik | Kyungpook Natl Univ, Dept Adv Sci & Technol Convergence, 2559 Gyeongsang Daero, Sangju Si 37224, Gyeongsangbuk D, South Korea; Kyungpook Natl Univ, Sch Nano & Adv Mat Engn, 2559 Gyeongsang Daero, Sangju Si 37224, Gyeongsangbuk D, South Korea; Sejong Univ, Nanotechnol & Adv Mat Engn, 209 Neungdong Ro, Seoul 143747, South Korea | ; Timilisina, Suman/GLT-8029-2022 | 57215092476; 55844969100; 56067767800; 16444690100 | sumantimilsina87@knu.ac.kr;jisikkim@knu.ac.kr; | ADVANCED SCIENCE | ADV SCI | 2198-3844 | 9 | 11 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY | 2022 | 15.1 | 6.8 | 2.9 | 2025-06-25 | 32 | 31 | crack-tip HRR field; mechanoluminescent skin; mechanoluminescent (ML) quantification; structural health monitoring; trap-controlled mechanism | STRESS INTENSITY FACTOR; CRACK-TIP; PRESSURE; BEHAVIOR; ZONE | crack-tip HRR field; mechanoluminescent (ML) quantification; mechanoluminescent skin; structural health monitoring; trap-controlled mechanism | Algorithms; Dacarbazine; Fingers; Plastics; Skin; Calibration; Crack propagation; Crack tips; Image analysis; Information use; Strain measurement; dacarbazine; plastic; Calibration curves; Correlation algorithm; Crack-tip HRR field; Digital image correlations; Effective strain; Mechanoluminescent quantification; Mechanoluminescent skin; Optical methods; Strain fields; Trap-controled mechanism; algorithm; finger; skin; Structural health monitoring | English | 2022 | 2022-04 | 10.1002/advs.202105889 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Ensemble Machine Learning-Based Approach for Predicting of FRP-Concrete Interfacial Bonding | Developments in fiber-reinforced polymer (FRP) composite materials have created a huge impact on civil engineering techniques. Bonding properties of FRP led to its wide usage with concrete structures for interfacial bonding. FRP materials show great promise for rehabilitation of existing infrastructure by strengthening concrete structures. Existing machine learning-based models for predicting the FRP-concrete bond strength have not attained maximum performance in evaluating the bond strength. This paper presents an ensemble machine learning approach capable of predicting the FRP-concrete interfacial bond strength. In this work, a dataset holding details of 855 single-lap shear tests on FRP-concrete interfacial bonds extracted from the literature is used to build a bond strength prediction model. Test results hold data of different material properties and geometrical parameters influencing the FRP-concrete interfacial bond. This study employs CatBoost algorithm, an improved ensemble machine learning approach used to accurately predict bond strength of FRP-concrete interface. The algorithm performance is compared with those of other ensemble methods (i.e., histogram gradient boosting algorithm, extreme gradient boosting algorithm, and random forest). The CatBoost algorithm outperforms other ensemble methods with various performance metrics (i.e., lower root mean square error (2.310), lower covariance (21.8%), lower integral absolute error (8.8%), and higher R-square (96.1%)). A comparative study is performed between the proposed model and best performing bond strength prediction models in the literature. The results show that FRP-concrete interfacial bonding can be effectively predicted using proposed ensemble method. | Kim, Bubryur; Lee, Dong-Eun; Hu, Gang; Natarajan, Yuvaraj; Preethaa, Sri; Rathinakumar, Arun Pandian | Kyungpook Natl Univ, Dept Robot & Smart Syst Engn, 80 Daehak Ro, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Architecture Civil Environm & Energy Engn, 80 Daehak Ro, Daegu 41566, South Korea; Harbin Inst Technol, Sch Civil & Environm Engn, Shenzhen 518055, Peoples R China; KPR Inst Engn & Technol, Dept Artificial Intelligence & Data Sci, Coimbatore 641407, Tamil Nadu, India; KPR Inst Engn & Technol, Artificial Intelligence Lab, Res Intern, Coimbatore 641407, Tamil Nadu, India | HU, Gang/P-8189-2018; Natarajan, Yuvaraj/GWV-2080-2022; raj, yuva/GWV-2080-2022; Hu, Gang/P-8189-2018 | 57198355299; 56605563300; 56735061500; 57204528689; 57214320928; 57416033800 | brkim@knu.ac.kr;dolee@knu.ac.kr;hugang@hit.edu.cn;yuvaraj.n@kpriet.ac.in;k.r.sripreethaa@kpriet.ac.in;arunrk7.leo@gmail.com; | MATHEMATICS | MATHEMATICS-BASEL | 2227-7390 | 10 | 2 | SCIE | MATHEMATICS | 2022 | 2.4 | 6.8 | 7.57 | 2025-06-25 | 41 | 50 | bond strength; ensemble methods; machine learning; shear bond test; boosting algorithms | SHEAR-STRENGTH; DEBONDING STRENGTH; NEURAL-NETWORK; RC BEAMS; FUZZY; MODEL; PERFORMANCE; PLATES | Bond strength; Boosting algorithms; Ensemble methods; Machine learning; Shear bond test | English | 2022 | 2022-01 | 10.3390/math10020231 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Portable Cold Atmospheric Plasma Patch-Mediated Skin Anti-Inflammatory Therapy | Although plasma is a promising technology in various fields, its clinical application is restricted by several limitations. A cold atmospheric plasma (CAP) patch is fabricated to help overcome hurdles, especially when treating skin diseases. This patch has surface dielectric barrier discharge, which generates reactive oxygen species (ROS) and reactive nitrogen species (RNS) on a flexible polymer film surface on which the embedded electrode induces a locally strong electric field. The effect of the CAP patch on psoriasis is also evaluated. The distinct characteristics of psoriasis between the lesion and non-lesion area allow the CAP patch to be suitable for only lesion area for its treatment. The CAP patch induces the opening of calcium channels in keratinocytes, thereby restoring abnormal keratinocyte differentiation and the collapse of the tight junction; thus, alleviating psoriatic symptoms. In addition, the favorable effect is due to the induction of ROS/RNS by the CAP patch, not the electric field generated during plasma generation. The findings indicate that the proposed portable CAP patch can help treat inflammatory skin disorders, especially psoriasis. As this can be used easily as a combination therapy with existing drugs, it may help reduce side effects caused by existing drugs. | Kim, Namkyung; Lee, Seunghun; Lee, Soyoung; Kang, Jinjoo; Choi, Young-Ae; Park, Jeongsu; Park, Chul-Kyu; Khang, Dongwoo; Kim, Sang-Hyun | Kyungpook Natl Univ, Sch Med, Cell & Matrix Res Inst, Dept Pharmacol, Daegu 41944, South Korea; Korea Inst Mat Sci, Dept Nanobio Convergence, Nano Surface Mat Div, Chang Won 51508, South Korea; Korea Res Inst Biosci & Biotechnol, Immunoregulatory Mat Res Ctr, Jeongeup 56212, South Korea; Gachon Univ, Sch Med, Dept Physiol, Incheon 21999, South Korea | ; Lee, Seunghun/GYR-2414-2022; Kim, Sang-Hyun/KQU-4555-2024 | 57216981866; 57203919907; 8537269200; 57216977823; 7404777420; 57219810289; 55821963900; 26039177500; 57210450420 | dkhang@gachon.ac.kr;shkim72@knu.ac.kr; | ADVANCED SCIENCE | ADV SCI | 2198-3844 | 9 | 34 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY | 2022 | 15.1 | 6.8 | 1.5 | 2025-06-25 | 18 | 17 | calcium channels; cold atmospheric plasma; portable electronic applications; psoriasis; reactive nitrogen species; reactive oxygen species | CALCIUM REGULATION; PSORIASIS; INFLAMMATION; BARRIER; PATHOGENESIS; PROTEINS | calcium channels; cold atmospheric plasma; portable electronic applications; psoriasis; reactive nitrogen species; reactive oxygen species | Anti-Inflammatory Agents; Plasma Gases; Calcium; Dielectric barrier discharge; Dielectric materials; Drug interactions; Nitrogen; Nitrogen plasma; Plasma applications; Polymer films; Semiconducting films; antiinflammatory agent; Anti-inflammatories; Calcium channels; Clinical application; Cold atmospheric plasmas; Electronics applications; Portable electronic application; Portable electronics; Psoriasi; Reactive nitrogen species; Reactive oxygen species; drug therapy; plasma gas; Oxygen | English | 2022 | 2022-12 | 10.1002/advs.202202800 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Practical Enhancements in Current Density and Power Generation of Bifacial Semitransparent Ultrathin CIGSe Solar Cells via Utilization of Wide Bandgap Zn-Based Buffer | Among many building-integrated semitransparent photovoltaics (BISTPVs), semitransparent ultrathin (STUT) Cu(In-x,Ga1-x)Se-2 (CIGSe) solar cells are distinguishable due to their potential high power conversion efficiency (PCE) among other thin-film solar cells, versatile applicability based on thin film deposition processes, high stability consisting of all inorganic compositions, and practical expandability to bifacial applications. However, the fundamental trade-off relationship between PCE and transparency limits the performance of BISTPV because implementing a higher semitransparency lowers the optical budget of incoming light. To expand the available optical budget and to enhance the PCE while maintaining a suitable transparency in STUT CIGSe solar cell with single-stage coevaporated 500-nm-thick absorber, an atomic layer deposited wide bandgap Zn(O,S) buffer is introduced as the replacement of conventional CdS buffer, which partially limits incoming light less than 520 nm in wavelength. As a replacement result, more incoming light becomes valid for power conversion, and the short circuit current density (J(sc)) has increased comparatively by 17%, which has directly lead to a large increase in PCE up to 12.41%. Furthermore, Zn(O,S) buffer in the STUT CIGSe solar cell also has enhanced the bifacial compatible efficiency (BCE), which has increased to 14.44% at 1.3 sun and 19.42% at 2.0 sun. | Kim, Dongryeol; Shin, Sang Su; Jo, Yonghee; Lee, Sang Min; Ahn, Seung Kyu; Cho, Jun-Sik; Yun, Jae Ho; Lee, Ho Seong; Park, Joo Hyung | Korea Inst Energy Res KIER, Photovolta Res Dept, Daejeon 34129, South Korea; Kyungpook Natl Univ, Sch Mat Sci & Engn, Daegu 41556, South Korea; Jeonbuk Natl Univ, Dept Elect Engn, Jeonju 54896, South Korea; Jeonbuk Natl Univ, Smart Grid Res Ctr, Jeonju 54896, South Korea | Yun, JaeHo/NGS-4691-2025; Park, Joo Hyung/AAL-5247-2020 | 57194069208; 57217686358; 57646774900; 57221452907; 45760971600; 7403535861; 56431966500; 55706810400; 57193059568 | joopark@kier.re.kr; | ADVANCED SCIENCE | ADV SCI | 2198-3844 | 9 | 13 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY | 2022 | 15.1 | 6.8 | 0.66 | 2025-06-25 | 8 | 8 | albedo effect; atomic layer deposition; bifacial compatible efficiencies; semitransparent ultrathin Cu(In1-x; Ga-x)Se-2; solar cells; Zn(O; S) buffers | BACK CONTACTS; LAYER; STABILITY; CDS; DEPOSITION; EFFICIENCY; ALBEDO; PHOTOVOLTAICS; PASSIVATION; PERFORMANCE | albedo effect; atomic layer deposition; bifacial compatible efficiencies; semitransparent ultrathin Cu(In<sub>1-x</sub>,Ga<sub>x</sub>)Se<sub>2</sub>; solar cells; Zn(O,S) buffers | Atomic layer deposition; Budget control; Cadmium sulfide; Cadmium sulfide solar cells; Economic and social effects; Energy gap; II-VI semiconductors; Solar power generation; Thin film solar cells; Thin films; Transparency; Albedo effects; Atomic-layer deposition; Bifacial compatible efficiency; CIGSe solar cells; Incoming light; Power conversion efficiencies; Semitransparent ultrathin cu(in1-x,gax)se2; Ultra-thin; Wide-band-gap; Zn(O,S) buffer; Efficiency | English | 2022 | 2022-05 | 10.1002/advs.202105436 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Recapitulated Crosstalk between Cerebral Metastatic Lung Cancer Cells and Brain Perivascular Tumor Microenvironment in a Microfluidic Co-Culture Chip | Non-small cell lung carcinoma (NSCLC), which affects the brain, is fatal and resistant to anti-cancer therapies. Despite innate, distinct characteristics of the brain from other organs, the underlying delicate crosstalk between brain metastatic NSCLC (BM-NSCLC) cells and brain tumor microenvironment (bTME) associated with tumor evolution remains elusive. Here, a novel 3D microfluidic tri-culture platform is proposed for recapitulating positive feedback from BM-NSCLC and astrocytes and brain-specific endothelial cells, two major players in bTME. Advanced imaging and quantitative functional assessment of the 3D tri-culture model enable real-time live imaging of cell viability and separate analyses of genomic/molecular/secretome from each subset. Susceptibility of multiple patient-derived BM-NSCLCs to representative targeted agents is altered and secretion of serpin E1, interleukin-8, and secreted phosphoprotein 1, which are associated with tumor aggressiveness and poor clinical outcome, is increased in tri-culture. Notably, multiple signaling pathways involved in inflammatory responses, nuclear factor kappa-light-chain-enhancer of activated B cells, and cancer metastasis are activated in BM-NSCLC through interaction with two bTME cell types. This novel platform offers a tool to elucidate potential molecular targets and for effective anti-cancer therapy targeting the crosstalk between metastatic cancer cells and adjacent components of bTME. | Kim, Hyunho; Sa, Jason K.; Kim, Jaehoon; Cho, Hee Jin; Oh, Hyun Jeong; Choi, Dong-Hee; Kong, Seok-Hyeon; Jeong, Da Eun; Nam, Do-Hyun; Lee, Hakho; Lee, Hye Won; Chung, Seok | Korea Univ, Coll Engn, Sch Mech Engn, Seoul 02841, South Korea; Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA; Korea Univ, Coll Med, Dept Biomed Sci, Seoul 02841, South Korea; Georgia Inst Technol, George W Woodruff Sch Mech Engn, Atlanta, GA 30332 USA; Kyungpook Natl Univ, Dept Biomed Convergence Sci & Technol, Daegu 41566, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, Daegu 41944, South Korea; Thermo Fisher Sci Solut, Life Sci & Lab Prod Grp, Biosci Div, Seoul 06349, South Korea; Samsung Med Ctr, Inst Refractory Canc Res, Seoul 06351, South Korea; Sungkyunkwan Univ, Samsung Adv Inst Hlth Sci & Technol SAIHST, Dept Hlth Sci & Technol, Seoul 06351, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Neurosurg, Seoul 06351, South Korea; Natl Canc Ctr, Ctr Urol Canc, Dept Urol, Goyang 10408, South Korea; Korea Univ, KU KIST Grad Sch Converging Sci & Technol, Seoul 02841, South Korea | Lee, Hakho/M-9004-2016; , Do Hyun Nam/C-9656-2011; Kim, Hyunho/GQH-5608-2022 | 57564175500; 56803454400; 56844764500; 55937716400; 55881971700; 57203276872; 57723414400; 59094163200; 57190971869; 35725732800; 57218088690; 7404292871 | nsproper@naver.com;sidchung@korea.ac.kr; | ADVANCED SCIENCE | ADV SCI | 2198-3844 | 9 | 22 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY | 2022 | 15.1 | 6.8 | 2.06 | 2025-06-25 | 22 | 23 | brain perivascular tumor microenvironment; cerebral metastatic lung cancer cells; microfluidic co-culture chip | CHEMOTHERAPY; CULTURE; GENES | brain perivascular tumor microenvironment; cerebral metastatic lung cancer cells; microfluidic co-culture chip | Brain; Carcinoma, Non-Small-Cell Lung; Coculture Techniques; Endothelial Cells; Humans; Lung Neoplasms; Microfluidics; Tumor Microenvironment; Brain; Cell signaling; Crosstalk; Diseases; Endothelial cells; Oncology; Tumors; Anti-cancer therapies; Brain perivascular tumor microenvironment; Brain tumors; Cerebral metastatic lung cancer cell; Co-cultures; Lung cancer cells; Metastatic lung cancer; Microfluidic co-culture chip; Non-small-cell lung carcinomata; Tumor microenvironments; brain; coculture; endothelium cell; human; lung tumor; metabolism; microfluidics; non small cell lung cancer; pathology; tumor microenvironment; Microfluidics | English | 2022 | 2022-08 | 10.1002/advs.202201785 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Semantic Segmentation of UAV Images Based on Transformer Framework with Context Information | With the advances in Unmanned Aerial Vehicles (UAVs) technology, aerial images with huge variations in the appearance of objects and complex backgrounds have opened a new direction of work for researchers. The task of semantic segmentation becomes more challenging when capturing inherent features in the global and local context for UAV images. In this paper, we proposed a transformer-based encoder-decoder architecture to address this issue for the precise segmentation of UAV images. The inherent feature representation of the UAV images is exploited in the encoder network using a self-attention-based transformer framework to capture long-range global contextual information. A Token Spatial Information Fusion (TSIF) module is proposed to take advantage of a convolution mechanism that can capture local details. It fuses the local contextual details about the neighboring pixels with the encoder network and makes semantically rich feature representations. We proposed a decoder network that processes the output of the encoder network for the final semantic level prediction of each pixel. We demonstrate the effectiveness of this architecture on UAVid and Urban Drone datasets, where we achieved mIoU of 61.93% and 73.65%, respectively. | Kumar, Satyawant; Kumar, Abhishek; Lee, Dong-Gyu | Kyungpook Natl Univ, Dept Artificial Intelligence, Daegu 41566, South Korea | Kumar, Abhishek/ABA-5251-2021 | 58029499800; 57206266703; 57169003900 | dglee@knu.ac.kr; | MATHEMATICS | MATHEMATICS-BASEL | 2227-7390 | 10 | 24 | SCIE | MATHEMATICS | 2022 | 2.4 | 6.8 | 1.89 | 2025-06-25 | 10 | 13 | semantic segmentation; UAV street scene images; transformer; global and local context | NETWORK; AERIAL; AGGREGATION | global and local context; semantic segmentation; transformer; UAV street scene images | English | 2022 | 2022-12 | 10.3390/math10244735 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Sulfisoxazole Elicits Robust Antitumour Immune Response Along with Immune Checkpoint Therapy by Inhibiting Exosomal PD-L1 | Despite their potent antitumor activity, clinical application of immune checkpoint inhibitors has been significantly limited by their poor response rates (<30%) in cancer patients, primarily due to immunosuppressive tumor microenvironments. As a representative immune escape mechanism, cancer-derived exosomes have recently been demonstrated to exhaust CD8(+) cytotoxic T cells. Here, it is reported that sulfisoxazole, a sulfonamide antibacterial, significantly decreases the exosomal PD-L1 level in blood when orally administered to the tumor-bearing mice. Consequently, sulfisoxazole effectively reinvigorates exhausted T cells, thereby eliciting robust antitumor effects in combination with anti-PD-1 antibody. Overall, sulfisoxazole regulates immunosuppression through the inhibition of exosomal PD-L1, implying its potential to improve the response rate of anti-PD-1 antibodies. | Shin, Jung Min; Lee, Chan-Hyeong; Son, Soyoung; Kim, Chan Ho; Lee, Jae Ah; Ko, Hyewon; Shin, Sol; Song, Seok Ho; Park, Seong-Sik; Bae, Ju-Hyun; Park, Ju-Mi; Choe, Eun-Ji; Baek, Moon-Chang; Park, Jae Hyung | Sungkyunkwan Univ, Coll Engn, Sch Chem Engn, 2066 Seobu Ro, Suwon 16419, South Korea; Natl Marine Biodivers Inst Korea MABIK, Dept Genet Resources, 75 Jangsan Ro 101 Gil, Seocheon 33662, South Korea; Kyungpook Natl Univ, Sch Med, Exosome Convergence Res Ctr ECRC, Dept Mol Med,CMRI, Daegu 41944, South Korea; Sungkyunkwan Univ, Dept Hlth Sci & Technol, SAIHST, 2066 Seobu Ro, Suwon 16419, South Korea; Korea Res Inst Biosci & Biotechnol, Bionanotechnol Res Ctr, 125 Gwahak Ro, Daejeon 34141, South Korea; Sungkyunkwan Univ, Biomed Inst Convergence SKKU BICS, 2066 Seobu Ro, Suwon 16419, South Korea | Park, Jae/B-5967-2018; Shin, Jung Min/KCJ-9261-2024 | 55812326800; 57189904697; 55923871300; 57192541703; 57205516398; 55982328200; 57192834809; 57196440394; 57378111300; 57225046295; 57221984091; 57377017300; 7006013097; 56113586400 | mcbaek@knu.ac.kr;jhparkl@skku.edu;jhpark1@skku.edu; | ADVANCED SCIENCE | ADV SCI | 2198-3844 | 9 | 5 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY | 2022 | 15.1 | 6.8 | 4.21 | 2025-06-25 | 46 | 46 | combination therapy; exosomal PD-L1; exosome; immune checkpoint therapy; immune escape; tumor microenvironment | EXTRACELLULAR VESICLES; CANCER-THERAPY; IMMUNOTHERAPY; PROGRESSION; LYMPHOCYTES | combination therapy; exosomal PD-L1; exosome; immune checkpoint therapy; immune escape; tumor microenvironment | Animals; B7-H1 Antigen; Exosomes; Humans; Immunity; Mice; Sulfisoxazole; Tumor Microenvironment; Antibodies; Diseases; Mammals; Sulfur compounds; Surveys; Tumors; programmed death 1 ligand 1; sulfafurazole; Anti-tumor immune; Combination therapy; Exosomal PD-l1; Exosomes; Immune checkpoint therapy; Immune escape; Immune response; Response rate; Sulfisoxazole; Tumor microenvironments; animal; exosome; human; immunity; mouse; tumor microenvironment; T-cells | English | 2022 | 2022-02 | 10.1002/advs.202103245 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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