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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Crystal Structure of Nitrilase-Like Protein Nit2 from Kluyveromyces lactis | The nitrilase superfamily, including 13 branches, plays various biological functions in signaling molecule synthesis, vitamin metabolism, small-molecule detoxification, and posttranslational modifications. Most of the mammals and yeasts have Nit1 and Nit2 proteins, which belong to the nitrilase-like (Nit) branch of the nitrilase superfamily. Recent studies have suggested that Nit1 is a metabolite repair enzyme, whereas Nit2 shows omega-amidase activity. In addition, Nit1 and Nit2 are suggested as putative tumor suppressors through different ways in mammals. Yeast Nit2 (yNit2) is a homolog of mouse Nit1 based on similarity in sequence. To understand its specific structural features, we determined the crystal structure of Nit2 from Kluyveromyces lactis (KlNit2) at 2.2 angstrom resolution and compared it with the structure of yeast-, worm-, and mouse-derived Nit2 proteins. Based on our structural analysis, we identified five distinguishable structural features from 28 structural homologs. This study might potentially provide insights into the structural relationships of a broad spectrum of nitrilases. | Jin, Chaewon; Jin, Hyeonseok; Jeong, Byung-Cheon; Cho, Dong-Hyung; Chun, Hang-Suk; Kim, Woo-Keun; Chang, Jeong Ho | Kyungpook Natl Univ, Dept Biol Educ, Daehak Ro 80, Daegu 41566, South Korea; Univ Texas Southwestern Med Ctr Dallas, Dept Pharmacol, Dallas, TX 75390 USA; Kyungpook Natl Univ, Sch Life Sci, Daegu 41566, South Korea; Korea Inst Toxicol, Biosyst Res Grp, Daejeon 34114, South Korea; Kyungpook Natl Univ, Dept Biomed Convergence Sci & Technol, Daehak Ro 80, Daegu 41566, South Korea | ; Choi, Hye Rin/JDV-9065-2023 | 57222486080; 57210943989; 24767334900; 35093684400; 56572094600; 36008772300; 57203598905 | jinchaewon178@gmail.com;jinhs@postech.ac.kr;Byung-Cheon.Jeong@utsouthwestern.edu;dhcho@knu.ac.kr;hangsuk.chun@kitox.re.kr;wookkim@kitox.re.kr;jhcbio@knu.ac.kr; | CRYSTALS | 2073-4352 | 11 | 5 | 0.08 | 2025-07-30 | 1 | 1 | Nit2; nitrilase superfamily; ω -amidase; Kluyveromyces lactis | ROSETTA STONE PROTEIN; ENZYME; INSIGHTS; REVEALS | Kluyveromyces lactis; Nit2; Nitrilase superfamily; ω-amidase | English | 2021 | 2021-05 | 10.3390/cryst11050499 | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | Article | Crystallinity of low molar ratio urea-formaldehyde resins modified with cellulose nanomaterials | Inherent crystalline domains present in low formaldehyde to urea (F/U) molar ratio urea-formaldehyde (UF) resins are responsible for their poor adhesion in wood-based composite panels. To modify the crystallinity of low molar ratio (LMR) UF resins, this study investigates the additional effect of cellulose nanomaterials (CNMs), such as cellulose microfibrils (CMFs), cellulose nanofibrils (CNFs), and TEMPO-oxidized CNFs (TEMPO-CNFs) on the crystallinity of modified LMR UF resins. First, two modification methods (post-mixing and in situ) were compared for modified LMR UF resins with TEMPO-CNFs. The modified UF resins with TEMPO-CNFs decreased the nonvolatile solid contents, while increasing the viscosity and gel time. However, the in situ modification of UF resins with TEMPO-CNFs showed lower crystallinity than that of post-mixing. Then, the in situ method was compared for all CNMs to modify LMR UF resins. The modified UF resins with CMFs using the in situ method increased nonvolatile solid contents and viscosity but decreased the gel time. The crystallinity of UF resins modified with TEMPO-CNFs was the lowest even though the crystalline domains were not significantly changed for all modified UF resins. These results suggest that these CNMs should be modified to prevent the formation of crystalline domains in LMR UF resins. © 2021, Korean Society of Wood Science Technology. All rights reserved. | Park, Seongsu; Park, Byung-Dae | Department of Wood and Paper Science, Kyungpook National University, Daegu, 41566, South Korea; Department of Wood and Paper Science, Kyungpook National University, Daegu, 41566, South Korea | 57220771754; 7402834820 | byungdae@knu.ac.kr; | Journal of the Korean Wood Science and Technology | 1017-0715 | 49 | 2 | 0.8 | 2025-07-30 | 10 | Cellulose nanomaterials; Crystallinity; Low molar ratio uf resins | Cellulose; Formaldehyde; Metabolism; Mixing; Polyureas; Cellulose; Formaldehyde; Metabolism; Mixing; Molar ratio; Nanostructured materials; Urea; Urea formaldehyde resins; Viscosity; Wood; Cellulose microfibrils; Cellulose nanofibrils; Cellulose nanomaterial; Cristallinity; Crystalline domains; Low molar ratio uf resin; Molar ratio; Nonvolatile solids; Solids content; Urea-formaldehyde resin; Crystallinity | English | Final | 2021 | 10.5658/wood.2021.49.2.169 | 바로가기 | 바로가기 | |||||||||||||||
| ○ | ○ | Article | CutLang v2: Advances in a Runtime-Interpreted Analysis Description Language for HEP Data | We will present the latest developments in CutLang, the runtime interpreter of a recently-developed analysis description language (ADL) for collider data analysis. ADL is a domain-specific, declarative language that describes the contents of an analysis in a standard and unambiguous way, independent of any computing framework. In ADL, analyses are written in human-readable plain text files, separating object, variable and event selection definitions in blocks, with a syntax that includes mathematical and logical operations, comparison and optimisation operators, reducers, four-vector algebra and commonly used functions. Adopting ADLs would bring numerous benefits to the LHC experimental and phenomenological communities, ranging from analysis preservation beyond the lifetimes of experiments or analysis software to facilitating the abstraction, design, visualization, validation, combination, reproduction, interpretation and overall communication of the analysis contents. Since their initial release, ADL and CutLang have been used for implementing and running numerous LHC analyses. In this process, the original syntax from CutLang v1 has been modified for better ADL compatibility, and the interpreter has been adapted to work with that syntax, resulting in the current release v2. Furthermore, CutLang has been enhanced to handle object combinatorics, to include tables and weights, to save events at any analysis stage, to benefit from multi-core/multi-CPU hardware among other improvements. In this contribution, these and other enhancements are discussed in details. In addition, real life examples from LHC analyses are presented together with a user manual. | Unel, G.; Sekmen, S.; Toon, A. M.; Gokturk, B.; Orgen, B.; Paul, A.; Ravel, N.; Setpal, J. | Univ Calif Irvine, Dept Phys & Astron, Irvine, CA 92697 USA; Kyungpook Natl Univ, Dept Phys, Daegu, South Korea; St Joseph Univ Beirut, Dept Comp Software Engn, Beirut, Lebanon; Bogazici Univ, Dept Phys, Istanbul, Turkey; Abdus Salam Int Ctr Theoret Phys, Trieste, Italy; Univ Ankatso, Dept Phys, Antananarivo, Madagascar; RN Podar Sch, Mumbai, Maharashtra, India | ; unel, gokhan/KFB-1065-2024 | 6603681553; 24172042700; 57218197765; 57226806952; 57226815376; 59836568000; 57226805990; 57220741406 | gokhan.unel@cern.ch; | FRONTIERS IN BIG DATA | FRONT BIG DATA | 2624-909X | 4 | ESCI | COMPUTER SCIENCE, INFORMATION SYSTEMS;COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS;MULTIDISCIPLINARY SCIENCES | 2021 | N/A | 0.14 | 2025-07-30 | 0 | 3 | LHC; collider; run time analysis; analysis description language; CutLang | MODEL; SMODELS; ROOT; LHC | analysis description language; collider; CutLang; LHC; run time analysis | English | 2021 | 2021-06-07 | 10.3389/fdata.2021.659986 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | Article | Cyclotron Resonance Line Widths in Wurtzite ZnO Structure under Circularly Oscillating Fields | We study optical quantum transition line widths in relation to magnetic field dependence properties of the electrons confined in an infinite square well potential system between z = 0 and z = L-z in the z - direction. We consider two systems-one is subject to right circularly oscillating external fields and the other is subject to left circularly oscillatory external fields. Our results indicate that the line widths of right circularly oscillating external fields is larger than the line widths of left, while the opposite result is obtained for the line widths. | Park, Jung-Il | Kyungpook Natl Univ, Dept Phys, Nanophys & Technol Lab, Daegu 41566, South Korea | jipark@knu.ac.kr; | JOURNAL OF THE KOREAN MAGNETIC RESONANCE SOCIETY | J KOREAN MAGN RESON | 1226-6531 | 25 | 4 | ESCI | BIOCHEMICAL RESEARCH METHODS | 2021 | N/A | 2 | Cyclotron resonance; line widths; absorption power; scattering factor function; wurtzite structure | DOPED LINBO3; SURFACE | English | 2021 | 2021 | 10.6564/jkmrs.2021.25.4.051 | 바로가기 | 바로가기 | 바로가기 | ||||||||||||
| ○ | Article | Daegu citizens' perceptions and factors affecting behavioral intentions to reduce sugars in the coffee shop beverages; [커피전문점 음료의 당류 줄이기에 대한 대구시민의 인식 및 행동의도에 영향을 미치는 요인] | Purpose: This study aimed to provide baseline data for establishing a sugar reduction policy at coffee shops by analyzing the factors that affect a coffee shop user's perception and behavioral intention of reducing sugar intake. Methods: An online survey was conducted involving 1,274 Daegu citizens aged 19-49 years, who had visited coffee shops within the last month. Results: When visiting a coffee shop, the purchase of sweet drinks was higher in the younger age group, and the addition of syrup or sugar was higher in the older age group. Of the total respondents, 42.1% were aware that some coffee shops accommodate reduced sugar requests, 57.9% perceived the need to reduce sugar in coffee shop beverages and 22.3% had purchased beverages intending to reduce their sugar intake. In addition, 59.7% knew about sugar nutrition labeling, and 68.8% perceived the need for nutrition labeling for sugar. When purchasing beverages, 35.6% checked the nutrition labeling, and 77.2% purchased alternative drinks when the sugar content was high. Guiding the choice of sweetness levels in coffee shop orders was seen to have the highest effectiveness and intention to reduce sugar intake. Moreover, the perceived need to reduce sugar intake had the most positive effect on the behavioral intention to reduce sugars in coffee shop beverages (β = 0.558, p < 0.001). Conclusion: Although the overall awareness and practice of reducing the sugar intake in coffee shop users were low, the behavioral intention to reduce sugars was positive, and this was most affected by the perception of the need to reduce sugars. Therefore, there is a need for differentiated education and promotion for each age group for recognizing the necessity and outlining methods for reducing sugar intake. Furthermore, coffee shops should reflect customer's sugar reduction needs. © 2021 Korean Nutrition Society. All rights reserved. | Kim, Kilye; Lee, Yeon-Kyung | Department of Food Science and Nutrition, Kyungpook National University, Daegu, 41566, South Korea; Department of Food Science and Nutrition, Kyungpook National University, Daegu, 41566, South Korea | 57218175604; 16301462200 | yklee@knu.ac.kr; | Journal of Nutrition and Health | 2288-3886 | 54 | 4 | 0 | 2025-07-30 | 0 | Beverages; Coffee; Intention; Perception; Sugar reduction | Korean | Final | 2021 | 10.4163/jnh.2021.54.4.355 | 바로가기 | 바로가기 | ||||||||||||||||
| ○ | ○ | Article; Data Paper | Data on complete genome sequence and annotation of Paenibacillus sonchi LMG 24727T | Paenibacillus sonchi LMG 24727(T) was acquired from the Belgian Coordinated Collections of Microorganisms (BCCM) isolated from Sonchus oleraceus rhizosphere soil. This strain is a gram-positive, aerobic, rod-shaped bacterium. The strain's genomic DNA was extracted using a Wizard (R) Genomic DNA Purification Kit, and whole-genome sequencing was performed using the Nanopore MinION platform. Whole-genome assembly was performed using Flye assembler, and a total 7,782,254 bp length of circular chromosome and two plasmids was assembled by using a 1,558,445,868 bp length of raw reads. Genome annotation by the Prokaryotic Genome Annotation Pipeline (PGAP) showed the complete genome to contain 50.6% G+C content; 6264 protein-coding genes; 27 rRNA genes; 89 tRNA genes; and 4 ncRNA genes. Additionally, multiple genes related to nitrogen metabolism were annotated from the Rapid Annotation using Subsystem Technology (RAST) server. The complete genome sequence data have been submitted to the National Center for Biotechnology Information (NCBI) and have been deposited at DDBJ/ENA/GenBank under the accession number CP068595.1, CP068596.1, and CP068597.1. (C) 2021 The Authors. Published by Elsevier Inc. | Lee, GyuDae; Kim, Min-Ji; Shin, Jae-Ho | Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea | shin, Jaeho/K-6792-2013 | 57222101785; 57127351600; 57224125922 | jhshin@knu.ac.kr; | DATA IN BRIEF | DATA BRIEF | 2352-3409 | 38 | ESCI | MULTIDISCIPLINARY SCIENCES | 2021 | N/A | 0.46 | 2025-07-30 | 2 | 2 | Complete genome; Nanopore technology; Nitrogen metabolism; Paenibacillus sonchi LMG 24727 | Complete genome; Nanopore technology; Nitrogen metabolism; Paenibacillus sonchi LMG 24727 | English | 2021 | 2021-10 | 10.1016/j.dib.2021.107271 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||||
| ○ | ○ | Article | Data-driven Analysis for Developing the Effective Groundwater Management System in Daejeong-Hangyeong Watershed in Jeju Island | In this study, the impact of clustered groundwater usage facilities and the proper amount of groundwater usage in the Daejeong-Hangyeong watershed of Jeju island were evaluated based on the data-driven analysis methods. As the applied data, groundwater level data; the corresponding precipitation data; the groundwater usage amount data (Jeoji, Geumak, Seogwang, and English-education city facilities) were used. The results show that the Geumak usage facility has a large influence centering on the corresponding location; the Seogwang usage facility affects on the downstream area; the English-education usage facility has a great impact around the upstream of the location; the Jeoji usage facility shows an influence around the up- and down-streams of the location. Overall, the influence of operating the clustered groundwater usage facilities in the watershed is prolonged to approximately 5km. Additionally, the appropriate groundwater usage amount to maintain the groundwater base-level was analyzed corresponding to the precipitation. Considering the recent precipitation pattern, there is a need to limit the current amount of groundwater usage to 80%. With increasing the precipitation by 100mm, additional groundwater development of approximately 1,500m(3) -1,900m(3) would be reasonable. All the results of the developed data-driven estimation model can be used as useful information for sustainable groundwater development in the Daejeong-Hangyeong watershed of Jeju island. | Lee, Soyeon; Jeong, Jiho; Kim, Minchul; Park, Wonbae; Kim, Yuhan; Park, Jaesung; Park, Heejeong; Park, Gyeongtae; Jeong, Jina | Kyungpook Natl Univ, Dept Geol, Daegu, South Korea; Jeju Res Inst, Jeju Groundwater Res Ctr, Jeju Special Self Govern, South Korea | 41261679800; 57218684286; 57226597968; 56262564000; 57226608853; 57226611192; 57226598607; 57226594931; 55488558800 | jeong.j@knu.ac.kr; | ECONOMIC AND ENVIRONMENTAL GEOLOGY | ECON ENVIRON GEOL | 1225-7281 | 2288-7962 | 54 | 3 | ESCI | GEOLOGY | 2021 | N/A | 0.1 | 2025-07-30 | 0 | 1 | Daejeong-Hangyeong watershed; groundwater level fluctuation pattern; clustered groundwater supply facility; groundwater level degradation; sensitivity analysis | VOLCANIC ISLAND; COASTAL AQUIFER; RESOURCES; MODEL | Clustered groundwater supply facility; Daejeong-Hangyeong watershed; Groundwater level degradation; Groundwater level fluctuation pattern; Sensitivity analysis | English | 2021 | 2021 | 10.9719/eeg.2021.54.3.373 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | Proceedings Paper | Demand Response: Multiagent System Based DR Implementation | Saeed, Faisal; Paul, Anand; Rho, Seungmin; Ahmed, Muhammad Jamal | Kyungpook Natl Univ, Dept Comp Sci & Engn, Daegu, South Korea; Sejong Univ, Dept Software, Seoul, South Korea | Rho, Seungmin/HTP-6683-2023; Ahmed, Muhammad Jamal/LRC-8144-2024 | ADVANCES IN ARTIFICIAL INTELLIGENCE AND APPLIED COGNITIVE COMPUTING | 2569-7072 | 2569-7080 | 0 | English | 2021 | 2021 | 10.1007/978-3-030-70296-0_68 | 바로가기 | 바로가기 | ||||||||||||||||||||||
| ○ | Conference paper | Democratizing LHC Data Analysis with ADL/CutLang | Data analysis at the LHC has a very steep learning curve, which erects a formidable barrier between data and anyone who wishes to analyze data, either to study an idea or to simply understand how data analysis is performed. To make analysis more accessible, we designed the so-called Analysis Description Language (ADL), a domain specific language capable of describing the contents of an LHC analysis in a standard and unambiguous way, independent of any computing frameworks. ADL has an English-like highly human-readable syntax and directly employs concepts relevant to HEP. Therefore it eliminates the need to learn complex analysis frameworks written based on general purpose languages such as C++ or Python, and shifts the focus directly to physics. Analyses written in ADL can be run on data using a runtime interpreter called CutLang, without the necessity of programming. ADL and CutLang are designed for use by anyone with an interest in, and/or knowledge of LHC physics, ranging from experimentalists and phenomenologists to non-professional enthusiasts. ADL/CutLang are originally designed for research, but are also equally intended for education and public use. This approach has already been employed to train undergraduate students with no programming experience in LHC analysis in two dedicated schools in Turkey and Vietnam, and is being adapted for use with LHC Open Data. Moreover, work is in progress towards piloting an educational module in particle physics data analysis for high school students and teachers. Here, we introduce ADL and CutLang and present the educational activities based on these practical tools. © Copyright owned by the author(s) under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0) | Sekmen, Sezen; Unel, Gokhan; Prosper, Harrison B.; Adiguzel, Aytul; Sen, Burak | Center for High Energy Physics, Kyungpook National University, Daegu, South Korea; Department of Physics and Astronomy, University of California at Irvine, Irvine, CA, United States; Department of Physics, Florida State University, Tallahassee, FL, United States; Physics Department, Istanbul University, Istanbul, Turkey; Department of Physics, Middle East Technical University, Ankara, Turkey | 24172042700; 6603681553; 59150153600; 35221167800; 57574189600 | ssekmen@cern.ch; | Proceedings of Science | 1824-8039 | 398 | 0 | 2025-07-30 | 0 | C++ (programming language); Information analysis; Open Data; Problem oriented languages; Program interpreters; Python; Students; Analysis frameworks; Complex analysis; Computing frameworks; Description languages; Domains specific languages; General-purpose languages; Human-readable syntax; Learn+; Runtimes; Steep learning curve; Data handling | English | Final | 2021 | 바로가기 | |||||||||||||||||||
| ○ | ○ | Article | Dependence of superconductivity on the crystallinity of Nb films on Si wafers | Among elemental metals, niobium (Nb) has the highest superconducting transition temperature (T-c) at ambient pressure. Thus, Nb films have been used in superconducting electronics and radio frequency cavity applications. In this study, the depositional factors determining the crystallinity and T-c of Nb films were investigated. An Nb film grown at a sputtering temperature of 240 degrees C exhibited the maximum crystallinity of Nb and the minimum crystallinity of niobium oxide. X-ray photoelectron spectroscopy confirmed a maximum atomic percent of niobium and a minimum atomic percent of oxygen. A sputtering power of 210 W and a sputtering time of 50 min were the optimal conditions for Nb deposition, and the T(c )of the optimized film (9.08 K) was close to that of bulk Nb (9.25 K). Transmission electron microscopy images of the thick film directly confirmed the removal of the typical in-plane compressive strain in the (110) plane caused by residual stress. | Choi, Joonyoung; Kim, Chang-Duk; Jo, Younjung | Kyungpook Natl Univ, Daegu, South Korea | 57199099536; 57200982445; 13502586500 | duks@knu.ac.kr;jophy@knu.ac.kr; | PROGRESS IN SUPERCONDUCTIVITY AND CRYOGENICS | PROG SUPERCOND CRYOG | 1229-3008 | 2287-6251 | 23 | 4 | ESCI | PHYSICS, APPLIED | 2021 | N/A | 0.07 | 2025-07-30 | 1 | 1 | critical fields; critical temperature; films; niobium compounds; sputtering; superconducting material growth | DEPOSITION; NIOBIUM | Critical fields; Critical temperature; Films, niobium compounds; Sputtering; Superconducting material growth | Crystallinity; Silicon wafers; Sputtering; Superconducting films; Superconducting transition temperature; Thick films; X ray photoelectron spectroscopy; Ambient pressures; Atomic percent; Cristallinity; Critical fields; Critical temperatures; Elemental metals; Film, niobium compound; Niobium films; Si wafer; Superconducting materials growth; High resolution transmission electron microscopy | English | 2021 | 2021-12 | 10.9714/psac.2021.23.4.001 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Article | Dependence of the ac loss on interval and stacking number in z stacked gdbco coated conductor | The 2G High-Tc superconductor-coated conductors (2G HTS CC) with large aspect ratios have large AC losses for a perpendicular external magnetic field. A reduction of the AC loss is an important issue in 2G HTS CC applications. In a previous study, stacking of HTS CC was found to increase the full penetration field Hp and to decrease the AC loss. The AC loss for the maximum applied magnetic field Hm below Hp was affected by the interval D and the staking number n. In this study, to reduce the AC loss, we stacked GdBCO-coated conductors with the same geometries and with regular D, and we measured the magnetization curves of the stacked samples at a temperature of 83 K (t = T/Tc = 0:88). The AC losses were calculated using the experimental results, and the AC losses of the stacked samples were compared with phose for the single-layer sample. We investigated the dependences on D and n of the AC losses of the stacked GdBCO CCs. As the interval decreases, the volume normalized AC loss decreased. In the case of D = 0.10 mm, the AC loss was decreased by 16% and 37% in the 2-layer structure and the 3-layer structure, respectively, compared with the 1-layer structure. © 2021 The Korean Physical Society. All rights reserved. | Kim, Chan; Kim, Young-Kyoung; Jeon, Sung-Min; Ri, H.C. | Department of Physics, Kyungpook National University, Daegu, 41566, South Korea; Department of Physics, Kyungpook National University, Daegu, 41566, South Korea; Department of Physics, Kyungpook National University, Daegu, 41566, South Korea; Department of Physics, Kyungpook National University, Daegu, 41566, South Korea | 54684058600; 57219092979; 57222536170; 56277557600 | hcri@knu.ac.kr; | New Physics: Sae Mulli | 0374-4914 | 71 | 2 | 0 | 2025-07-30 | 0 | Ac Loss; Coated Conductor; High Tc Superconductor; Stacked Structure | Korean | Final | 2021 | 10.3938/npsm.71.111 | 바로가기 | 바로가기 | ||||||||||||||||
| ○ | Article | Depletion of mitochondrial components from extracellular vesicles secreted from astrocytes in a mouse model of fragile x syndrome | Mitochondrial dysfunction contributes to neurodegenerative diseases and developmental disorders such as Fragile X syndrome (FXS). The cross-talk between mitochondria and extracellular vesicles (EVs) suggests that EVs may transfer mitochondrial components as intermediators for intracellular communication under physiological and pathological conditions. In the present study, the ability of EVs to transfer mitochondrial components and their role in mitochondrial dysfunction in astrocytes were examined in the brains of Fmr1 knockout (KO) mice, a model of FXS. The amounts of mitochondrial transcription factor NRF-1, ATP synthases ATP5A and ATPB, and the mitochondrial membrane protein VDAC1 in EVs were reduced in cerebral cortex samples and astrocytes from Fmr1 KO mice. These reductions correspond to decreased mitochondrial biogenesis and transcriptional activities in Fmr1 KO brain, along with decreased mitochondrial membrane potential (MMP) with abnormal localization of vimentin intermediate filament (VIF) in Fmr1 KO astrocytes. Our results suggest that mitochondrial dysfunction in astrocytes is associated with the pathogenesis of FXS and can be monitored by depletion of components in EVs. These findings may improve the ability to diagnose developmental diseases associated with mitochondrial dysfunction, such as FXS and autism spectrum disorders (ASD). © 2021 by the authors. Licensee MDPI, Basel, Switzerland. | Ha, Byung Geun; Heo, Jung-Yoon; Jang, Yu-Jin; Park, Tae-Shin; Choi, Ju-Yeon; Jang, Woo Young; Jeong, Sung-Jin | Research Group of Developmental Disorders and Rare Diseases, Korea Brain Research Institute (KBRI), Daegu, 41062, South Korea; Research Group of Developmental Disorders and Rare Diseases, Korea Brain Research Institute (KBRI), Daegu, 41062, South Korea; Research Group of Developmental Disorders and Rare Diseases, Korea Brain Research Institute (KBRI), Daegu, 41062, South Korea; Research Group of Developmental Disorders and Rare Diseases, Korea Brain Research Institute (KBRI), Daegu, 41062, South Korea; Research Group of Developmental Disorders and Rare Diseases, Korea Brain Research Institute (KBRI), Daegu, 41062, South Korea; Research Group of Developmental Disorders and Rare Diseases, Korea Brain Research Institute (KBRI), Daegu, 41062, South Korea, School of Life Science and Biotechnology, Kyungpook National University, 1370 Sankyuk-dong, Buk-ku, Daegu, 41566, South Korea; Research Group of Developmental Disorders and Rare Diseases, Korea Brain Research Institute (KBRI), Daegu, 41062, South Korea, Department of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, 42988, South Korea | 57221440855; 57221444128; 57199785040; 57221443979; 57221443331; 57542419000; 57211726638 | sjjeong@kbri.re.kr; | International Journal of Molecular Sciences | 1661-6596 | 22 | 1 | 1.25 | 2025-07-30 | 18 | Astrocytes; Extracellular vesicles; Fmr1 knockout mouse; Fragile X syndrome; Mitochondrial dysfunction | Animals; Astrocytes; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Extracellular Vesicles; Fragile X Mental Retardation Protein; Fragile X Syndrome; Immunohistochemistry; Male; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Electron, Transmission; Mitochondria; atp5a protein; atpb protein; proton transporting adenosine triphosphate synthase; transcription factor Nrf1; unclassified drug; vimentin; voltage dependent anion channel 1; Fmr1 protein, mouse; fragile X mental retardation protein; animal cell; animal experiment; animal model; Article; astrocyte; brain cortex; controlled study; exosome; extracellular space; fragile X syndrome; genetic transcription; intermediate filament; knockout mouse; male; mitochondrial biogenesis; mitochondrial membrane; mitochondrial membrane potential; mitochondrion; mouse; mouse model; nonhuman; animal; astrocyte; C57BL mouse; cell culture; disease model; exosome; fragile X syndrome; genetics; immunohistochemistry; metabolism; mitochondrion; transmission electron microscopy; ultrastructure | English | Final | 2021 | 10.3390/ijms22010410 | 바로가기 | 바로가기 | |||||||||||||||
| ○ | ○ | Article | Derivation and validation of a combined in-hospital mortality and bleeding risk model in acute myocardial infarction | Background: In the potent new antiplatelet era, it is important issue how to balance the ischemic risk and the bleeding risk. However, previous risk models have been developed separately for in-hospital mortality and major bleeding risk. Therefore, we aimed to develop and validate a novel combined model to predict the combined risk of in-hospital mortality and major bleeding at the same time for initial decision making in patients with acute myocardial infarction (AMI). Methods: Variables from the Korean Acute Myocardial Infarction Registry (KAMIR) - National Institute of Health (NIH) database were used to derive (n = 8955) and validate (n = 3838) a multivariate logistic regression model. Major adverse cardiovascular events (MACEs) were defined as in-hospital death and major bleeding. Results: Seven factors were associated with MACE in the model: age, Killip class, systolic blood pressure, heart rate, serum glucose, glomerular filtration rate, and initial diagnosis. The risk model discriminated well in the derivation (c-static = 0.80) and validation (c-static = 0.80) cohorts. The KAMIR-NIH risk score was developed from the model and corresponded well with observed MACEs: very low risk (0.9%), low risk (1.7%), moderate risk (4.2%), high risk (8.6%), and very high risk (23.3%). In patients with MACEs, a KAMIR-NIH risk score 10 was associated with high in-hospital mortality. Conclusion: The KAMIR-NIH in-hospital MACEs model using baseline variables stratifies comprehensive risk for in-hospital mortality and major bleeding, and is useful for guiding initial decision making. (C) 2021 The Authors. Published by Elsevier B.V. | Kim, Hong Nyun; Lee, Jang Hoon; Kim, Hyeon Jeong; Park, Bo Eun; Jang, Se Yong; Bae, Myung Hwan; Yang, Dong Heon; Park, Hun Sik; Cho, Yongkeun; Jeong, Myung Ho; Park, Jong-Seon; Kim, Hyo-Soo; Hur, Seung-Ho; Seong, In-Whan; Cho, Myeong-Chan; Kim, Chong-Jin; Chae, Shung Chull | Kyungpook Natl Univ Hosp, Dept Internal Med, 130 Dongdeok Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Daegu, South Korea; Chonnam Natl Univ Hosp, Dept Internal Med, Gwangju, South Korea; Yeungnam Univ Hosp, Dept Internal Med, Daegu, South Korea; Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea; Keimyung Univ, Dept Internal Med, Dongsan Med Ctr, Daegu, South Korea; Chungnam Natl Univ Hosp, Dept Internal Med, Daejeon, South Korea; Chungbuk Natl Univ Hosp, Dept Internal Med, Cheongju, South Korea; Kyung Hee Univ, Dept Internal Med, East West Neo Med Ctr, Seoul, South Korea | Kim, Jin Sug/AAY-6890-2021; Park, Hang-soo/AEH-1640-2022; Kim, Sang-Hyun/J-5402-2012 | 56706769800; 54581258000; 57204359002; 57201131446; 57207977889; 36607356800; 35277423400; 57198844106; 9249593500; 56485157500; 15763054600; 33567809200; 34570274500; 35254371300; 7401727518; 35229511500; 7101962036 | ljhmh75@knu.ac.kr; | IJC HEART & VASCULATURE | IJC HEART VASC | 2352-9067 | 33 | ESCI | CARDIAC & CARDIOVASCULAR SYSTEMS | 2021 | N/A | 0.19 | 2025-07-30 | 2 | 2 | Acute myocardial infarction; Mortality; Bleeding; Risk stratification | PERCUTANEOUS CORONARY INTERVENTION; OUTCOMES; CLOPIDOGREL; TICAGRELOR; PRASUGREL; REGISTRY; SCORE | Acute myocardial infarction; Bleeding; Mortality; Risk stratification | acetylsalicylic acid; angiotensin receptor antagonist; beta adrenergic receptor blocking agent; clopidogrel; creatine kinase MB; dipeptidyl carboxypeptidase inhibitor; heart enzyme; hemoglobin; prasugrel; statin (protein); ticagrelor; acute heart infarction; all cause mortality; area under the curve; Article; bleeding; body mass; brain hemorrhage; coronary artery disease; diabetes mellitus; electrocardiogram; estimated glomerular filtration rate; glomerulus filtration rate; glucose blood level; heart ejection fraction; heart left ventricle ejection fraction; heart rate; hematocrit; hospital mortality; hyperlipidemia; hypertension; KAMIR NIH risk score system; major adverse cardiac event; model; non ST segment elevation myocardial infarction; receiver operating characteristic; risk; scoring system; smoking; ST segment elevation myocardial infarction; systolic blood pressure; validation study | English | 2021 | 2021-04 | 10.1016/j.ijcha.2021.100732 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | Article | Design and analysis of a low-cost approximate adder with OR and zero truncation | This paper proposes a new cost-effective approximate adder that exploits OR operation and zero truncation. The proposed approximation technique reduces the hardware cost significantly while maintaining comparable computation accuracy. The proposed adder achieved 48%, 51%, and 48% reductions in the area, delay, and power, respectively, compared to a traditional adder when implemented in 32-nm CMOS technology. The proposed design could also enhance the normalized mean error distance up to 29% compare to the approximate adders considered in this paper. The adder showed an excellent tradeoff performance between the hardware and computation accuracy. Furthermore, the proposed adder was adopted in a digital image processing application, and the benefit of the proposed adder is demonstrated. Copyrights © 2021 The Institute of Electronics and Information Engineers | Seo, Hyoju; Lee, Jungwon; Lee, Donghui; Kim, Beomjun; Kim, Yongtae | School of Computer Science and Engineering, Kyungpook National University, Daegu, South Korea; School of Computer Science and Engineering, Kyungpook National University, Daegu, South Korea; School of Computer Science and Engineering, Kyungpook National University, Daegu, South Korea; School of Computer Science and Engineering, Kyungpook National University, Daegu, South Korea; School of Computer Science and Engineering, Kyungpook National University, Daegu, South Korea | 57215662369; 57219710729; 57266466900; 57743131700; 55699627900 | yongtae@knu.ac.kr; | IEIE Transactions on Smart Processing and Computing | 2287-5255 | 10 | 4 | 0.14 | 2025-07-30 | 2 | Approximate adder; Approximate computing; Low-cost; Lower-part OR truncation adder (LOTA); Zero truncation | Cost benefit analysis; Cost effectiveness; Costs; Image processing; Approximation techniques; CMOS technology; Computation accuracy; Cost effective; Design and analysis; Digital image; Hardware cost; Mean error distances; Adders | English | Final | 2021 | 10.5573/ieiespc.2021.10.4.309 | 바로가기 | 바로가기 | |||||||||||||||
| ○ | Article | Design and performance study of fabry–perot filter based on DBR for a non-dispersive infrared carbon dioxide sensor | A highly sensitive and selective non-dispersive infrared (NDIR) carbon dioxide gas sensor requires achieving high transmittance and narrow full width at half maximum (FWHM), which depends on the interface of the optical filter for precise measurement of carbon dioxide concentration. This paper presents the design, simulation, and fabrication of a Fabry–Perot filter based on a distributed Bragg reflector (DBR) for a low-cost NDIR carbon dioxide sensor. The Fabry–Perot filter consists of upper and lower DBR pairs, which comprise multilayered stacks of alternating high- and low-index thin films, and a cavity layer for the resonance of incident light. As the number of DBR pairs inside the reflector increases, the FWHM of the transmitted light becomes narrower, but the transmittance of light decreases substantially. Therefore, it is essential to analyze the relationship between the FWHM and transmittance according to the number of DBR pairs. The DBR is made of silicon and silicon dioxide by RF magnetron sputtering on a glass wafer. After the optimal conditions based on simulation results were realized, the DBR exhibited a light transmittance of 38.5% at 4.26 μm and an FWHM of 158 nm. The improved results substantiate the advantages of the low-cost and minimized process compared to expensive commercial filters. © 2021 The Authors. | Do, Nam Gon; Lee, Junyeop; Jung, Dong Geon; Kong, Seong Ho; Jung, Daewoong | Safety System R&D Group, Korea Institute of Industrial Technology, 320, Techno sunhwan-ro, Yuga-eup, Dalseong-gun, Daegu, South Korea, School of Electrical Engineering, Kyungpook National University, 80, Daehak-ro, Buk-gu, Daegu, South Korea; Safety System R&D Group, Korea Institute of Industrial Technology, 320, Techno sunhwan-ro, Yuga-eup, Dalseong-gun, Daegu, South Korea, School of Electrical Engineering, Kyungpook National University, 80, Daehak-ro, Buk-gu, Daegu, South Korea; Safety System R&D Group, Korea Institute of Industrial Technology, 320, Techno sunhwan-ro, Yuga-eup, Dalseong-gun, Daegu, South Korea; School of Electrical Engineering, Kyungpook National University, 80, Daehak-ro, Buk-gu, Daegu, South Korea; Safety System R&D Group, Korea Institute of Industrial Technology, 320, Techno sunhwan-ro, Yuga-eup, Dalseong-gun, Daegu, South Korea | 58569191700; 57203736115; 56675241000; 57204537951; 36019307900 | dwjung@kitech.re.kr; | Journal of Sensor Science and Technology | 1225-5475 | 30 | 4 | 0.27 | 2025-07-30 | 3 | Carbon dioxide (CO2); Distributed bragg reflector; Fabry-Perot filter; Non-dispersive infrared (NDIR) | Korean | Final | 2021 | 10.46670/jsst.2021.30.4.250 | 바로가기 | 바로가기 |
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