연구성과로 돌아가기
2022 연구성과 (24 / 280)
※ 컨트롤 + 클릭으로 열별 다중 정렬 가능합니다.
Excel 다운로드
| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ○ | ○ | Article | Repositioning Food and Drug Administration-Approved Drugs for Inhibiting Biliverdin IXβ Reductase B as a Novel Thrombocytopenia Therapeutic Target | Biliverdin IX beta reductase B (BLVRB) has recently been proposed as a novel therapeutic target for thrombocytopenia through its reactive oxygen species (ROS)-associated mechanism. Thus, we aim at repurposing drugs as new inhibitors of BLVRB. Based on IC50 (<5 mu M), we have identified 20 compounds out of 1496 compounds from the Food and Drug Administration (FDA)-approved library and have clearly mapped their binding sites to the active site. Furthermore, we show the detailed BLVRB-binding modes and thermodynamic properties (Delta H, Delta S, and K-D) with nuclear magnetic resonance (NMR) and isothermal titration calorimetry together with complex structures of eight water-soluble compounds. We anticipate that the results will serve as a novel platform for further in-depth studies on BLVRB effects for related functions such as ROS accumulation and megakaryocyte differentiation, and ultimately treatments of platelet disorders. | Kim, Myeongkyu; Ha, Jung-Hye; Choi, Joonhyeok; Kim, Bo-Ram; Gapsys, Vytautas; Lee, Ko On; Jee, Jun-Goo; Chakrabarti, Kalyan S.; de Groot, Bert L.; Griesinger, Christian; Ryu, Kyoung-Seok; Lee, Donghan | Korea Basic Sci Inst, Prot Struct Res Team, Cheongju 28119, Chungcheongbuk, South Korea; Max Planck Inst Biophys Chem, Dept NMR Based Struct Biol, D-37077 Gottingen, Germany; Daegu Gyeongbuk Med Innovat Fdn DGMIF, New Drug Dev Ctr, Daegu 41061, South Korea; Max Planck Inst Biophys Chem, Dept Theoret & Computat Biophys, D-37077 Gottingen, Germany; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, Daegu 41566, South Korea; Krea Univ, Div Sci, Sri City 517646, Andhra Pradesh, India; Univ Louisville, James Graham Brown Canc Ctr, Dept Med, Louisville, KY 40202 USA | Gapsys, Vytautas/AAF-7922-2020; chakrabarti, kalyan/A-4583-2013 | 57402864600; 55913461400; 57216851937; 57210748025; 37121791500; 55206686300; 7004327823; 36939163500; 7003590166; 7005617296; 34875746100; 55698900600 | cigr@nmr.mpibpc.mpg.de;ksryu@kbsi.re.kr;donghan.lee@louisville.edu; | JOURNAL OF MEDICINAL CHEMISTRY | J MED CHEM | 0022-2623 | 1520-4804 | 65 | 3 | SCIE | CHEMISTRY, MEDICINAL | 2022 | 7.3 | 5.8 | 0.59 | 2025-06-25 | 6 | 6 | PARTICLE MESH EWALD; FLAVIN REDUCTASE; FORCE-FIELDS; PHLOXINE-B; BILIRUBIN; FEATURES; VITRO | Catalytic Domain; Crystallography, X-Ray; Drug Repositioning; Enzyme Inhibitors; Humans; Molecular Dynamics Simulation; Nuclear Magnetic Resonance, Biomolecular; Oxidoreductases Acting on CH-CH Group Donors; Protein Binding; Small Molecule Libraries; Thermodynamics; United States; United States Food and Drug Administration; biliverdin; erythrosine; oxidoreductase; oxidoreductase inhibitor; phloxine; reactive oxygen metabolite; biliverdin reductase; enzyme inhibitor; oxidoreductase; protein binding; Article; binding site; cell differentiation; controlled study; drug approval; drug binding; drug repositioning; enzyme activity; Food and Drug Administration; IC50; isothermal titration calorimetry; megakaryopoiesis; nonhuman; nuclear magnetic resonance; protein function; protein multimerization; thermodynamics; thrombocytopenia; chemistry; drug repositioning; enzyme active site; human; metabolism; molecular dynamics; molecular library; United States; X ray crystallography | English | 2022 | 2022-02-10 | 10.1021/acs.jmedchem.1c01664 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Soluble ANPEP Released From Human Astrocytes as a Positive Regulator of Microglial Activation and Neuroinflammation: Brain Renin- Angiotensin System in Astrocyte-Microglia Crosstalk | Astrocytes are major supportive glia and immune modu-lators in the brain; they are highly secretory in nature and interact with other cell types via their secreted proteomes. To understand how astrocytes communicate during neu-roinflammation, we profiled the secretome of human as-trocytes following stimulation with proinflammatory factors. A total of 149 proteins were significantly upregu-lated in stimulated astrocytes, and a bioinformatics anal-ysis of the astrocyte secretome revealed that the brain renin-angiotensin system (RAS) is an important mecha-nism of astrocyte communication. We observed that the levels of soluble form of aminopeptidase N (sANPEP), an RAS component that converts angiotensin (Ang) III to Ang IV in a neuroinflammatory milieu, significantly increased in the astrocyte secretome. To elucidate the role of sANPEP and Ang IV in neuroinflammation, we first evaluated the expression of Ang IV receptors in human glial cells because Ang IV mediates biological effects through its receptors. The expression of angiotensin type 1 receptor was considerably upregulated in activated human micro-glial cells but not in human astrocytes. Moreover, inter-leukin-1 beta release from human microglial cells was synergistically increased by cotreatment with sANPEP and its substrate, Ang III, suggesting the proinflammatory ac-tion of Ang IV generated by sANPEP. In a mouse neuro-inflammation model, brain microglial activation and proinflammatory cytokine expression levels were increased by intracerebroventricular injection of sANPEP and attenuated by an enzymatic inhibitor and neutralizing antibody against sANPEP. Collectively, our results indicate that astrocytic sANPEP-induced increase in Ang IV exacerbates neuroinflammation by interacting with microglial proinflammatory receptor angiotensin type 1 receptor, highlighting an important role of indirect cross-talk between astrocytes and microglia through the brain RAS in neuroinflammation. | Kim, Jong-Heon; Afridi, Ruqayya; Cho, Eunji; Yoon, Jong Hyuk; Lim, Yong-Hyun; Lee, Ho-Won; Ryu, Hoon; Suk, Kyoungho | Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, Daegu, South Korea; Korea Brain Res Inst, Neurodegenerat Dis Res Grp, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Ctr Selforganizing Software Platform, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Neurol, Daegu, South Korea; Brain Sci Inst, Korea Inst Sci & Technol, Ctr Neuromed & Neurosci, Seoul, South Korea; Boston Univ, Alzheimers Dis Ctr, Boston, MA USA; Boston Univ, Sch Med, Dept Neurol, Boston, MA USA | ; Ryu, Hoon/MCJ-9411-2025 | 57203324811; 57200759784; 55863428700; 57212513350; 57202416711; 35337240700; 7202277209; 7005114595 | ksuk@knu.ac.kr; | MOLECULAR & CELLULAR PROTEOMICS | MOL CELL PROTEOMICS | 1535-9484 | 21 | 11 | SCIE | BIOCHEMICAL RESEARCH METHODS | 2022 | 7 | 5.8 | 1.2 | 2025-06-25 | 15 | 16 | FACTOR-KAPPA-B; AMINOPEPTIDASE N/CD13; CD13 GP150; T-CELLS; IV; CYTOKINE; LIPOPOLYSACCHARIDE; ENRICHMENT; INHIBITORS; DISEASE | Animals; Astrocytes; Brain; CD13 Antigens; Disease Models, Animal; Humans; Mice; Microglia; Neuroinflammatory Diseases; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; angiotensin 1 receptor; ether; interleukin 1beta; isoflurane; messenger RNA; microsomal aminopeptidase; monoclonal antibody; neutralizing antibody; nitrite; angiotensin 1 receptor; microsomal aminopeptidase; animal experiment; animal model; animal tissue; Article; astrocyte; bioinformatics; clinical article; controlled study; cytokine release; disease exacerbation; human; human cell; human tissue; macrophage activation; male; microglia; mouse; mouse model; mRNA expression level; nervous system inflammation; neuroimmunology; nonhuman; protein blood level; protein cerebrospinal fluid level; receptor upregulation; renin angiotensin aldosterone system; secretome; Y-maze test; animal; brain; disease model; metabolism; renin angiotensin aldosterone system | English | 2022 | 2022-11 | 10.1016/j.mcpro.2022.100424 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Ssu72-HNF4α signaling axis classify the transition from steatohepatitis to hepatocellular carcinoma | Growing evidence suggests a mechanistic link between steatohepatitis and hepatocellular carcinoma (HCC). However, the lack of representative animal models hampers efforts to understand pathophysiological mechanisms underlying steatohepatitis-related HCC. We found that liver-specific deletion of Ssu72 phosphatase in mice, leads to a high incidence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis, but not HCC. However, loss of Ssu72 drastically increased the probability of HCC developing, as well as the population of hepatic progenitors, in various chemical and metabolic syndrome-induced HCC models. Importantly, hepatic Ssu72 loss resulted in the induction of mature hepatocyte-to-progenitor cell conversion, by dedifferentiation orchestrated by Ssu72-mediated hypo-phosphorylation of hepatocyte nuclear factor 4 alpha (HNF4 alpha), a master regulator of hepatocyte function. Our findings suggest that Ssu72-mediated HNF4 alpha transcription contributes to the progression of steatohepatitis-associated HCC by regulating the dedifferentiation potential of hepatocytes. Thus, targeting the Ssu72-mediated HNF4 alpha signaling that underlies the pathogenesis of steatohepatitis-associated HCC development could be a novel therapeutic intervention for steatohepatitis-associated HCC. | Kim, Hyun-Soo; Yoon, Joon-Sup; Jeon, Yoon; Park, Eun-Ji; Lee, Jin-Kwan; Chen, Si; Lee, Ho; Park, Jee Young; Go, Heounjeong; Lee, Chang-Woo | Sungkyunkwan Univ, Samsung Med Ctr, Dept Mol Cell Biol, Sch Med, Suwon, South Korea; Natl Canc Ctr, Grad Sch Canc Sci & Policy, Res Inst, Goyang, South Korea; Curogen Technol, Res Inst, Suwon, South Korea; Kyungpook Natl Univ, Med Ctr, Sch Med, Dept Pathol, Daegu, South Korea; Univ Ulsan, Asan Med Ctr, Dept Pathol, Coll Med, Seoul, South Korea | ; Lee, Chang-Woo/L-5093-2015; Park, Jung Hwan/AAA-1951-2022 | 59262134000; 57285599300; 35310444600; 57218420991; 57002023400; 58125374100; 55183466500; 57226185359; 57204538826; 55700508300 | jazz7780@skku.edu;cwlee1234@skku.edu; | CELL DEATH AND DIFFERENTIATION | CELL DEATH DIFFER | 1350-9047 | 1476-5403 | 29 | 3 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CELL BIOLOGY | 2022 | 12.4 | 5.8 | 0.51 | 2025-06-25 | 8 | 6 | NUCLEAR FACTOR 4-ALPHA; LIVER; PHOSPHORYLATION; HEPATOCYTES; REGENERATION; PROGENITORS; HOMEOSTASIS; PROGRESSION; HNF4-ALPHA; REVEALS | Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Hepatocyte Nuclear Factor 4; Hepatocytes; Liver Neoplasms; Mice; Non-alcoholic Fatty Liver Disease; cell protein; hepatocyte nuclear factor 4alpha; Ssu72 phosphatase; unclassified drug; hepatocyte nuclear factor 4; animal experiment; animal model; animal tissue; Article; cell dedifferentiation; cell function; cell maturation; controlled study; human; human tissue; incidence; liver cell; liver cell carcinoma; major clinical study; male; mouse; nonalcoholic fatty liver; nonalcoholic steatohepatitis; nonhuman; protein depletion; protein phosphorylation; signal transduction; steatohepatitis; stem cell; animal; genetics; liver tumor; metabolism; nonalcoholic fatty liver; pathology; tumor cell line | English | 2022 | 2022-03 | 10.1038/s41418-021-00877-x | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Targeting the Aryl Hydrocarbon Receptor with Microbial Metabolite Mimics Alleviates Experimental Colitis in Mice | Targeting the aryl hydrocarbon receptor (AhR) isan emerging therapeutic strategy for multiple diseases (e.g.,inflammatory bowel disease).Thermosporothrix hazakensismicro-bial metabolite 2-(1 ' H-indole-3 '-carbonyl)-thiazole-4-carboxylicacid methyl ester (ITE) is a putative AhR endogenous ligand.To improve the chemical stability, we synthesized a series of ITEchemical mimics. Using a series of in vitro assays, we identified 2-(1H-indole-3-carbonyl)-N-methyl thiazole-4-carboxamide (ITE-CONHCH3) as a highly potent (EC50= 1.6 nM) AhR agonistwith high affinity (Ki= 88 nM). ITE-CONHCH3triggered AhRnuclear translocation and dimerization of AhR-ARNT, enhancedAhR binding in the CYP1A1 promoter, and induced AhR-regulated genes in an AhR-dependent manner. The metabolic stability of ITE-CONHCH3in a cell culture was 10 times higherthan that of ITE. Finally, we observed protective effects of ITE-CONHCH3in mice with DSS-induced colitis. Overall, wedemonstrate and validate a concept of microbial metabolite mimicry in the therapeutic targeting of AhR | Grycova, Aneta; Joo, Hansol; Maier, Vitezslav; Illes, Peter; Vyhlidalova, Barbora; Poulikova, Karolina; Sladekova, Lucia; Nadvornik, Petr; Vrzal, Radim; Zemankova, Lenka; Pecinkova, Petra; Poruba, Martin; Zapletalova, Iveta; Vecera, Rostislav; Anzenbacher, Pavel; Ehrmann, Jiri; Ondra, Peter; Jung, Jong-Wha; Mani, Sridhar; Dvorak, Zdenek | Palacky Univ, Dept Cell Biol & Genet, Fac Sci, Olomouc 78371, Czech Republic; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, Daegu 41566, South Korea; Univ Hosp Olomouc, Dept Forens Med & Med Law, Olomouc 77900, Czech Republic; Palacky Univ, Fac Med & Dent, Dept Pharmacol, Olomouc 77900, Czech Republic; Palacky Univ, Fac Med & Dent, Dept Clin & Mol Pathol, Olomouc 77900, Czech Republic | ; Zapletalová, Iveta/AAA-2142-2022; Maier, Vitezslav/A-6838-2011; Zapletalova, Iveta/AAA-2142-2022; Grycova, Aneta/AGH-1515-2022; Dvorak, Zdenek/A-1710-2008; Ehrmann, Jiri/C-9074-2009; Vyhlídalová, Barbora/HSE-7656-2023 | 56857604600; 57651840300; 8674428400; 56765462600; 56002389600; 57205647621; 57444497800; 9735838500; 8676824100; 55343963200; 57216407004; 56096436300; 57202780232; 56058388500; 7006074707; 7003794225; 6603083672; 26032128600; 7103268298; 44861288800 | zdenek.dvorak@upol.cz; | JOURNAL OF MEDICINAL CHEMISTRY | J MED CHEM | 0022-2623 | 1520-4804 | 65 | 9 | SCIE | CHEMISTRY, MEDICINAL | 2022 | 7.3 | 5.8 | 1.47 | 2025-06-25 | 16 | 15 | CELL-LINE; T-CELLS; AHR; LIGAND; INDOTHIAZINONE; CONSTRUCTION; ITE | Animals; Colitis; Cytochrome P-450 CYP1A1; Indoles; Mice; Receptors, Aryl Hydrocarbon; Thiazoles; aromatic hydrocarbon receptor; cytochrome P450 1A1; indole derivative; thiazole derivative; animal; colitis; genetics; metabolism; mouse | English | 2022 | 2022-05-12 | 10.1021/acs.jmedchem.2c00208 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | A twin-archive guided decomposition based multi/many-objective evolutionary algorithm | Decomposition-based Multi-Objective Evolutionary Algorithms (DMOEAs) gained popularity due to their ability to handle Multi/Many-objective Optimization Problems (MOPs/MaOPs). On the other hand, the weight vector adaptation strategy in DMOEAs is an essential ingredient for better performance, especially when dealing with MaOPs with irregular Pareto Front (PF). In general, an effective weight vector adaptation strategy faces challenges like identification of ineffective weight vectors, the proper timing and frequency of adaptation, reallocation of ineffective weight vectors and effective estimation of reference points. DMOEAs proposed in the literature try to address a subset of these issues, but fail to handle all of them simultaneously. In this paper, we propose a DMOEA namely 'A Twin-Archive Guided Decomposition based Multi/Many-objective Evolutionary Algorithm' (TAG-DMOEA) that basically employs two archives to update weight vectors and to estimate nadir point, separately. The better performance of TAG-DMOEA is validated over 10 representative state-of-the-art algorithms on 16 test problems with the number of objectives ranging from 2 to 10. The empirical results demonstrate the effectiveness of TAG-DMOEA on MOPs/MaOPs in both regular and irregular PFs. | Raju, Sri Srinivasa; Mallipeddi, Rammohan; Das, Kedar Nath | Natl Inst Technol Silchar, Dept Math, Silchar, India; Kyungpook Natl Univ, Sch Elect Engn, Dept Artificial Intelligence, Daegu, South Korea | Mallipeddi, Rammohan/AAL-5306-2020; M, Sri Srinivasa Raju/GNH-4935-2022 | 57575288000; 25639919900; 55220472200 | mallipeddi.ram@gmail.com; | SWARM AND EVOLUTIONARY COMPUTATION | SWARM EVOL COMPUT | 2210-6502 | 2210-6510 | 71 | SCIE | COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE;COMPUTER SCIENCE, THEORY & METHODS | 2022 | 10 | 5.9 | 3.56 | 2025-06-25 | 18 | 21 | Decomposition; Evolutionary algorithm; Weight vector adaptation; Nadir point; Archive guided; Many objective | MOEA/D | Archive guided; Decomposition; Evolutionary algorithm; Many objective; Nadir point; Weight vector adaptation | Frequency estimation; Multiobjective optimization; Vectors; Adaptation strategies; Archive guided; Many objective; Many-objective optimizations; Multi-Objective Evolutionary Algorithm; Nadir point; Optimization problems; Performance; Weight vector; Weight vector adaptation; Evolutionary algorithms | English | 2022 | 2022-06 | 10.1016/j.swevo.2022.101082 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Development of model output statistics based on the least absolute shrinkage and selection operator regression for forecasting next-day maximum temperature in South Korea | Regression models for model output statistics (MOS) based on least absolute shrinkage and selection operator methods were developed to forecast next-day maximum surface air temperature (TMAX) during the warm season in South Korea. The forecast fields from the operational numerical weather prediction (NWP) system of the Korean Meteorological Administration for global and local forecasts and the observed TMAX data in 225 observation stations were used as input variables for the MOS. The training period was July and August (JA) from 2015 to 2018, and the regression models were tested using data from JA 2019. As a result of hindcasting for the test period, the MOS models performed significantly better for next-day TMAX forecasting over South Korea than the numerical models during JA 2019. The mean TMAX errors were reduced by over 1 degrees C in MOSs compared to those in the numerical models. However, the TMAX forecast performance was generally lower in the higher-resolution NWP Local Data Assimilation and Prediction System (LDAPS)-based MOS (LMOS) than in the lower-resolution NWP Global Data Assimilation and Prediction System (GDAPS)-based MOS. This pattern was dominant when LDAPS simulated the TMAX more accurately than average. In particular, the random TMAX error of LDAPS was larger than that of GDAPS during the training period, and a positive random error of TMAX was magnified in LMOS. Because the other predictors forecasted from LDAPS can be associated with lower TMAX forecast performance of LMOS, in addition to TMAX effects as a predictor, a new MOS was developed using both LDAPS and GDAPS outputs. The forecast accuracy was improved by up to 0.3 degrees C when the forecast fields from the GDAPS substituted several LMOS predictors, even though TMAX was the primary predictor for LMOS. | Yoon, Donghyuck; Kim, Kyoungmin; Cha, Dong-Hyun; Lee, Myong-In; Im, Jungho; Cho, Dongjin; Min, Ki-Hong | Ulsan Natl Inst Sci & Technol, Dept Urban & Environm Engn, Ulsan, South Korea; Kyungpook Natl Univ, Dept Astron & Atmospher Sci, Daegu, South Korea | Cho, Dongjin/JCE-3252-2023; Lee, Myong-In/F-3578-2010; Yoon, Donghyuck/ISS-5217-2023; Im, Jungho/K-6257-2017; Cha, Dong-Hyun/F-4901-2015 | 57204630556; 59614001100; 55418553100; 58530782000; 9036557400; 57216491769; 37089364100 | dhcha@unist.ac.kr; | QUARTERLY JOURNAL OF THE ROYAL METEOROLOGICAL SOCIETY | Q J ROY METEOR SOC | 0035-9009 | 1477-870X | 148 | 745 | SCIE | METEOROLOGY & ATMOSPHERIC SCIENCES | 2022 | 8.9 | 5.9 | 0.48 | 2025-06-25 | 5 | 5 | least absolute shrinkage and selection operator; maximum temperature; model output statistics; South Korea | CLIMATE-CHANGE; HEAT-WAVE; MORTALITY; MOS; PRECIPITATION; ENSEMBLE | least absolute shrinkage and selection operator; maximum temperature; model output statistics; South Korea | South Korea; Errors; Numerical models; Regression analysis; Shrinkage; Data assimilation systems; Data prediction; Global data assimilation system; Least absolute shrinkage and selection operators; Local data; Maximum temperature; Model output statistics; Prediction systems; South Korea; Statistic-based; forecasting method; numerical model; prediction; regression analysis; statistical analysis; temperature anomaly; Weather forecasting | English | 2022 | 2022-04 | 10.1002/qj.4286 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Genomic characteristics of invasive mucinous adenocarcinoma of the lung with multiple pulmonary sites of involvement | Invasive mucinous adenocarcinoma (IMA) of the lung frequently presents with diffuse pneumonic-type features or multifocal lesions, which are regarded as a pattern of intrapulmonary metastases. However, the genomics of multifocal IMAs have not been well studied. We performed whole exome sequencing on samples taken from 2 to 5 regions in seven patients with synchronous multifocal IMAs of the lung (24 regions total). Early initiating driver events, such as KRAS, NKX2-1, TP53, or ARID1A mutations, are clonal mutations and were present in all multifocal IMAs in each patient. The tumor mutational burden of multifocal IMAs was low (mean: 1.13/mega base), but further analyses suggested intra-tumor heterogeneity. The mutational signature analysis found that IMAs were predominantly associated with endogenous mutational process (signature 1), APOBEC activity (signatures 2 and 13), and defective DNA mismatch repair (signature 6), but not related to smoking signature. IMAs synchronously located in the bilateral lower lobes of two patients with background usual interstitial pneumonia had different mutation types, suggesting that they were double primaries. In conclusion, genomic evidence found in this study indicated the clonal intrapulmonary spread of diffuse pneumonic-type or multifocal IMAs, although they can occur in multicentric origins in the background of usual interstitial pneumonia. IMAs exhibited a heterogeneous genomic landscape despite the low somatic mutation burden. Further studies are warranted to determine the clinical significance of the genomic characteristics of IMAs in expanded cohorts. | Kim, Moonsik; Hwang, Jinha; Kim, Kyung A.; Hwang, Sohyun; Lee, Hye-Jeong; Jung, Ji Ye; Lee, Jin Gu; Cha, Yoon Jin; Shim, Hyo Sup | Kyungpook Natl Univ, Sch Med, Dept Pathol, Chilgok Hosp, Daegu, South Korea; Macrogen Inc, Seoul, South Korea; Korea Univ, Dept Lab Med, Anam Hosp, Seoul, South Korea; Yonsei Univ, Dept Pathol, Coll Med, Seoul, South Korea; CHA Univ, Dept Pathol, Sch Med, Seongnam, South Korea; Yonsei Univ, Severance Hosp, Dept Radiol, Coll Med, Seoul, South Korea; Yonsei Univ, Severance Hosp, Res Inst Radiol Sci, Coll Med, Seoul, South Korea; Yonsei Univ, Severance Hosp, Dept Internal Med, Div Pulmonol,Coll Med, Seoul, South Korea; Yonsei Univ, Severance Hosp, Dept Thorac & Cardiovasc Surg, Coll Med, Seoul, South Korea | ; Jung, Ji/AAB-4993-2021; Lee, Jae/W-5616-2018; Lee, Jiwon/CAJ-1171-2022; Shim, Hyo/ABI-6190-2020 | 57195918515; 57226239680; 57051591800; 23989054900; 56144770400; 35744802400; 7601483079; 37076648200; 8701798400 | shimhs@yuhs.ac; | MODERN PATHOLOGY | MODERN PATHOL | 0893-3952 | 1530-0285 | 35 | 2 | SCIE | PATHOLOGY | 2022 | 7.5 | 5.9 | 3.67 | 2025-06-25 | 23 | 24 | TUMOR MUTATIONAL BURDEN; FUSION GENE; CANCER; HETEROGENEITY; KRAS; CLASSIFICATION; IMMUNOTHERAPY; INSTABILITY; ALIGNMENT; PROGRAM | Adenocarcinoma of Lung; Adenocarcinoma, Mucinous; Genomics; Humans; Lung; Lung Neoplasms; Mutation; apolipoprotein B mRNA editing enzyme catalytic polypeptide like; cell protein; epidermal growth factor receptor 2; homeobox protein Nkx 2.1; K ras protein; protein arid1a; protein p53; unclassified drug; adult; aged; Article; cancer localization; cancer size; cancer staging; chromosome 12p; chromosome 14; chromosome 6; chromosome 8; chromosome 9; clinical article; colloid carcinoma; copy number variation; female; gene amplification; gene deletion; gene duplication; gene frequency; gene insertion; genetic association; genetic heterogeneity; genotype; human; human tissue; interstitial pneumonia; lung adenocarcinoma; lung fibrosis; lung transplantation; lymph node metastasis; male; middle aged; mismatch repair; multiple cancer; mutation rate; phylogenetic tree; retrospective study; single nucleotide polymorphism; smoking habit; somatic mutation; tumor depth; tumor invasion; tumor mutational burden; whole exome sequencing; genetics; genomics; lung; lung tumor; mutation; pathology | English | 2022 | 2022-02 | 10.1038/s41379-021-00872-0 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Greater Plasma Protein Adsorption on Mesoporous Silica Nanoparticles Aggravates Atopic Dermatitis | Purpose: The protein corona surrounding nanoparticles has attracted considerable attention as it induces subsequent inflammatory responses. Although mesoporous silica nanoparticles (MSN) are commonly used in medicines, cosmetics, and packaging, the inflammatory effects of the MSN protein corona on the cutaneous system have not been investigated till date. Methods: We examined the greater plasma protein adsorption on MSN leads to serious inflammatory reactions in Dermatophagoides farinae extract (DFE)-induced mouse atopic dermatitis (AD)-like skin inflammation because of increased uptake by keratinocytes. Results: We compare the AD lesions induced by MSN and colloidal (non-porous) silica nanoparticles (CSN), which exhibit different pore architectures but similar dimensions and surface chemistry. MSN-corona treatment of severe skin inflammation in a DFE-induced in vivo AD model greatly increases mouse ear epidermal thickness and infiltration of immune cells compared with the CSN-corona treatment. Moreover, MSN-corona significantly increase AD-specific immunoglobulins, serum histamine, and Th1/Th2/Th17 cytokines in the ear and lymph nodes. MSN-corona induce more severe cutaneous inflammation than CSN by significantly decreasing claudin-1 expression. Conclusion: This study demonstrates the novel impact of the MSN protein corona in inducing inflammatory responses through claudin-1 downregulation and suggests useful clinical guidelines for MSN application in cosmetics and drug delivery systems. | Choi, Jin Kyeong; Park, Jun-Young; Lee, Soyoung; Choi, Young-Ae; Kwon, Song; Shin, Min Jun; Yun, Hui-Suk; Jang, Yong Hyun; Kang, Jinjoo; Kim, Namkyung; Khang, Dongwoo; Kim, Sang-Hyun | Jeonbuk Natl Univ, Dept Immunol, Med Sch, Jeonju 54907, South Korea; Gachon Univ, Lee Gil Ya Canc & Diabet Inst, Incheon 21999, South Korea; Korea Res Inst Biosci & Biotechnol, Immunoregulatory Mat Res Ctr, Jeongeup 56212, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pharmacol, CMRI, Daegu 41944, South Korea; Gachon Univ, Dept Hlth Sci & Technol, GAIHST, Incheon 21999, South Korea; Korea Inst Mat Sci, Powder & Ceram Div, Chang Won 51508, South Korea; Kyungpook Natl Univ, Sch Med, Dept Dermatol, Daegu 41944, South Korea; Gachon Univ, Sch Med, Dept Physiol, Incheon 21999, South Korea | 50261279600; 57211684904; 8537269200; 7404777420; 57210259677; 57430311700; 48762347400; 57016046400; 57216977823; 57216981866; 26039177500; 57210450420 | dkhang@gachon.ac.kr;shkim72@knu.ac.kr; | INTERNATIONAL JOURNAL OF NANOMEDICINE | INT J NANOMED | 1178-2013 | 17 | SCIE | NANOSCIENCE & NANOTECHNOLOGY;PHARMACOLOGY & PHARMACY | 2022 | 8 | 5.9 | 0.74 | 2025-06-25 | 8 | 8 | protein Corona; atopic dermatitis; mesoporous silica; colloidal silica; claudin-1; immunotoxicity | CELLULAR UPTAKE; COLLOIDAL SILICA; CORONA FORMATION; IMMUNOTOXICITY; CELLS; NANOTECHNOLOGY; CYTOTOXICITY; INFLAMMATION; PENETRATION; MECHANISMS | atopic dermatitis; claudin-1; colloidal silica; immunotoxicity; mesoporous silica; protein Corona | Adsorption; Animals; Claudin-1; Cytokines; Dermatitis, Atopic; Histamine; Immunoglobulin E; Inflammation; Mice; Mice, Inbred BALB C; Nanoparticles; Plant Extracts; Protein Corona; Silicon Dioxide; claudin 1; colloidal silica; cytokine; dust mite extract; histamine; immunoglobulin; mesoporous silica nanoparticle; plasma protein; protein corona; claudin 1; cytokine; histamine; immunoglobulin E; nanoparticle; plant extract; protein corona; silicon dioxide; adsorption kinetics; animal cell; animal experiment; animal model; animal tissue; Article; atopic dermatitis; cell infiltration; controlled study; disease severity; ear; epidermal thickness; female; histamine blood level; human; human cell; immunocompetent cell; in vivo study; keratinocyte; lymph node; mouse; nonhuman; physical chemistry; protein expression; surface property; Th1 cell; Th17 cell; Th2 cell; adsorption; animal; atopic dermatitis; Bagg albino mouse; inflammation; metabolism | English | 2022 | 2022 | 10.2147/ijn.s383324 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | Meeting Abstract | IMPACT OF SARCOPENIA AND ADVANCED FIBROSIS ON CARDIOVASCULAR RISK IN PATIENTS WITH METABOLIC-ASSOCIATED FATTY LIVER DISEASE | Lee, Jae Chang; Kim, Kye Whon; Kang, Min Kyu; Lee, Yu Rim; Jang, Se Young; Kweon, Young Oh; Tak, Won Young; Park, Soo Young; Park, Jung Gil | Yeungnam Univ, Coll Med, Internal Med, Gyongsan, South Korea; Kyungpook Natl Univ, Sch Med, Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Daegu, Daegu, South Korea | Park, Jung/AAK-5167-2020; Kang, Min/U-8050-2018; Kim, Jin Hyoung/AAE-8050-2019 | HEPATOLOGY | HEPATOLOGY | 0270-9139 | 1527-3350 | 76 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2022 | 14 | 5.9 | 0 | English | 2022 | 2022-10 | 바로가기 | 바로가기 | ||||||||||||||||
| ○ | Meeting Abstract | NONINVASIVE PREDICTION OF HEPATOCELLULAR CARCINOMA DEVELOPMENT AFTER ORAL ANTIVIRAL THERAPY IN PATIENTS WITH CHRONIC HEPATITIS C: A MULTICENTER STUDY | Lee, Yu Rim; Park, Jung Gil; Kang, Min Kyu; Song, Jeongeun; Jang, Byoung-Kuk; Kweon, Young-Oh; Tak, Won Young; Jang, Se Young; Lee, Tae Han; Kweon, Hyuk Ju; Park, Joon Woo; Kim, Tae Gyun; Lee, Chang-Hyeong; Kim, Byung Seok; Hwang, Jaeseok; Chung, Woo Jin; Heo, Jeong; Woo, Hyun Young; Hur, Keun; Lee, Hye Won; Park, Soo Young | Kyungpook Natl Univ, Internal Med, Sch Med, Daegu, South Korea; Yeungnam Univ, Coll Med, Internal Med, Gyongsan, South Korea; Daegu Catholic Univ, Sch Med, Gyongsan, South Korea; Keimyung Univ, Dongsang Hosp, Daegu, South Korea; Kyungpook Natl Univ Hosp, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Internal Med, Coll Med, Daegu, South Korea; Kyungpook Natl Univ Hosp, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Daegu, South Korea; Daegu Catholic Univ, Sch Med, Internal Med, Gyongsan, South Korea; Daegu Catholic Univ, Med Ctr, Gyongsan, South Korea; Keimyung Univ, Daegu, South Korea; Keimyung Univ, Internal Med, Daegu, South Korea; Pusan Natl Univ & Med Res Inst, Busan, South Korea; Pusan Natl Univ, Dept Internal Med, Coll Med, Busan, South Korea; Kyungpook Natl Univ, Dept Biochem & Cell Biol, Sch Med, Daegu, South Korea; Keimyung Univ, Sch Med, Dept Pathol, Daegu, South Korea | Kim, Seul Kee/A-6076-2015; Hur, Keun/G-9513-2011; Park, Jung/AAK-5167-2020; Kang, Min/U-8050-2018; Jeong, Sook-Hyang/J-5642-2012; Kim, TaeHeon/KIC-2380-2024 | HEPATOLOGY | HEPATOLOGY | 0270-9139 | 1527-3350 | 76 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2022 | 14 | 5.9 | 1 | English | 2022 | 2022-10 | 바로가기 | 바로가기 | ||||||||||||||||
| ○ | Meeting Abstract | OUTCOMES BY BASELINE LIVER FUNCTION IN PATIENTS WITH UNRESECTABLE HEPATOCELLULAR CARCINOMA TREATED WITH TREMELIMUMAB AND DURVALUMAB IN THE PHASE 3 HIMALAYA STUDY | Vogel, Arndt; Chan, Stephen L.; Furuse, Junji; Tak, Won Young; Masi, Gianluca; Varela, Maria; Kim, Jee Hyun; Tanasanvimon, Suebpong; Reig, Maria; Dayyani, Farshid; Makowsky, Mallory; Marcovitz, Michelle; Negro, Alejandra; Abou-Alfa, Ghassan K. | Hannover Med Sch, Hannover, Germany; Chinese Univ Hong Kong, Sir Yue Kong Pao Ctr Canc, Hong Kong, Peoples R China; Kyorin Univ Fac Med, Mitaka, Tokyo, Japan; Kyungpook Natl Univ, Sch Med, Daegu, South Korea; Pisa Univ, Pisa, Italy; Univ Oviedo, Hosp Univ Cent Asturias, Oviedo, Spain; Seoul Natl Univ Bundang Hosp, Seoul Natl Univ Coll Med, Seongnam, South Korea; Chulalongkorn Univ, King Chulalongkorn Mem Hosp, Fac Med, Bangkok, Thailand; Barcelona Univ, Hosp Clin Barcelona, Barcelona Clin Liver Canc BCLC, Barcelona, Spain; Univ Calif Irvine, Orange, CA USA; Astrazeneca, Gaithersburg, MD USA; Mem Sloan Kettering Canc Ctr, New York, NY USA; Cornell Univ, Weill Med Coll, New York, NY USA | Chan, Stephen/F-9149-2011; Vogel, Arndt/A-8437-2012; Reig, Maria/ABB-5414-2021; Dayyani, Farshid/CAF-8867-2022 | HEPATOLOGY | HEPATOLOGY | 0270-9139 | 1527-3350 | 76 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2022 | 14 | 5.9 | 0 | English | 2022 | 2022-10 | 바로가기 | 바로가기 | ||||||||||||||||
| ○ | Meeting Abstract | SAFETY AND EFFICACY AT 1 YEAR IN CHILDREN AND ADOLESCENTS WITH CHRONIC HEPATITIS B (CHB) RECEIVING TENOFOVIR ALAFENAMIDE (TAF) | Schwarz, Kathleen B.; Bezerra, Jorge A.; Choe, Byung-Ho; Lin, Chuan-Hao; Abramov, Frida; Nguyen, Anh-Hoa; Liu, Yang; Flaherty, John F.; Pacurar, Daniela; Kim, Kyung Mo; Khaertynova, Ilsiyar; Shalimar; Wu, Jia-Feng; Tandon, Manish; Rosenthal, Philip; Morozov, Viacheslav; Sokal, Etienne; Chang, Mei-Hwei | Cincinnati Childrens Hosp Med Ctr, Div Pediat Gastroenterol, Cincinnati, OH USA; Cincinnati Childrens Hosp Med Ctr, Div Gastroenterol Hepatol & Nutr, Cincinnati, OH USA; Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu, South Korea; Childrens Hosp Los Angeles, Los Angeles, CA USA; Univ Southern Calif, Los Angeles, CA USA; Gilead Sci Inc, Foster City, CA USA; Gilead Sci, Foster City, CA USA; Univ Med & Pharm Bucharest, Grigore Alexandrescu Emergency Clin Hosp Children, Bucharest, Romania; Ulsan Coll Med, Childrens Hosp, Asan Med Ctr, Seoul, South Korea; Kazan State Med Acad, Kazan, Russia; All India Inst Med Sci, Dept Gastroenterol, New Delhi, India; Natl Taiwan Univ Hosp, Pediat, Taipei, Taiwan; MV Hosp & Res Ctr, Lucknow, Uttar Pradesh, India; Univ Calif San Francisco, San Francisco, CA USA; Hepatolog, Samara, Russia; Catholic Univ Louvain, Cliniques St Luc, Ottignies, Belgium | Pacurar, Daniela/IYS-1131-2023; Wu, Jia-Feng/H-8125-2019; Rosenthal, Philip/AGG-3493-2022; WU, JIA-FENG/H-8125-2019; Lin, Chuan-Hao/AAH-6563-2019; Choe, Byung-Ho/KSM-6251-2024 | HEPATOLOGY | HEPATOLOGY | 0270-9139 | 1527-3350 | 76 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2022 | 14 | 5.9 | 0 | English | 2022 | 2022-10 | 바로가기 | 바로가기 | ||||||||||||||||
| ○ | ○ | Review | Unraveling the fundamentals of pulsed laser-assisted synthesis of nanomaterials in liquids: Applications in energy and the environment | Nanomaterials with high purity and functionality are in high demand for diverse applications in the energy and environmental domains, making them an intensively researched issue. The production of novel electro- and photoactive nanomaterials has been profoundly influenced by synthetic routes that make possible the development of surface and crystalline-tuned advanced materials. The significant size and textural tailored properties of materials synthesized through laser interaction with matter have emerged as a promising synthetic technique. The high-power pulsed laser-assisted synthesis of nanomaterials in liquids provides many degrees of parameter control (i.e., pulsed laser power, wavelength, reaction time duration, laser pulse repetition rate, and solvent) and numerous advantages over traditional physical and chemical synthetic methods, such as high purity, no byproducts, simple, nontoxic, and no need for surfactants and reducing agents. We first focused on the fundamental insights into the mechanism of pulsed laser techniques in depth in this paper, taking into account various experimental conditions to accelerate hypotheses that are appropriate for the production of efficient nanomaterials. We focused on the advancement of electro- and photoactive nanomaterials using pulsed laser synthetic technologies, which allowed us to reveal detailed mechanistic and textural properties as well as effective applications in energy and environmental processes. Finally, the challenges and possible future prospects for the emerging field of pulsed laser-based nanomaterials are concisely proposed. Published under an exclusive license by AIP Publishing. | Theerthagiri, Jayaraman; Karuppasamy, K.; Min, Ahreum; Govindarajan, Durai; Kumari, M. L. Aruna; Muthusamy, Govarthanan; Kheawhom, Soorathep; Kim, Hyun-Seok; Choi, Myong Yong | Gyeongsang Natl Univ, Res Inst Nat Sci, Core Facil Ctr Photochem & Nanomat, Dept Chem BK21 FOUR, Jinju 52828, South Korea; Dongguk Univ Seoul, Div Elect & Elect Engn, Seoul 04620, South Korea; Chulalongkorn Univ, Fac Engn, Dept Chem Engn, Bangkok 10330, Thailand; Oxford Coll Sci, Dept Chem, Bengaluru 560102, Karnataka, India; Kyungpook Natl Univ, Dept Environm Engn, Daegu 41566, South Korea; Saveetha Dent Coll & Hosp, Saveetha Inst Med & Tech Sci, Dept Biomat, Chennai 600077, India | Karuppasamy, K/ABE-1289-2020; Govarthanan, Muthusamy/C-1491-2014; Kheawhom, Soorathep/L-2683-2018; M.L., Aruna/AAJ-7548-2021; Muthusamy, Govarthanan/C-1491-2014 | 55510359000; 59164055500; 35722537600; 57202982270; 57198310468; 54881927600; 55897360400; 53663604300; 9041502300 | mychoi@gnu.ac.kr; | APPLIED PHYSICS REVIEWS | APPL PHYS REV | 1931-9401 | 9 | 4 | SCIE | PHYSICS, APPLIED | 2022 | 15 | 5.9 | 2.03 | 2025-06-25 | 73 | 74 | ENHANCED PHOTOCATALYTIC ACTIVITY; GRAPHENE OXIDE SHEETS; FACILE SYNTHESIS; AT-ZNO; METAL NANOPARTICLES; CATALYTIC-REDUCTION; TIO2 NANOPARTICLES; ORGANIC POLLUTANTS; ACTIVATED CARBON; AQUEOUS-SOLUTION | Environmental technology; Nanostructured materials; Pulse repetition rate; Reducing agents; Advanced materials; Diverse applications; Electro actives; Energy; Energy and the environment; High demand; High purity; Laser-assisted; Synthetic routes; Tailored properties; Pulsed lasers | English | 2022 | 2022-12 | 10.1063/5.0104740 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Biodistribution and respiratory toxicity of chloromethylisothiazolinone/ methylisothiazolinone following intranasal and intratracheal administration | A variety of isothiazolinone-containing small molecules have been registered and used as chemical additives in many household products. However, their biodistribution and potential harmful effects on human health, especially respiratory effects, were not yet identified in sufficient detail. The purpose of this study was to investigate whether a biocide comprising a mixture of chloromethylisothiazolinone (CMIT) and methylisothiazolinone (MIT) could reach the lungs and induce lung injury when exposure occurs by two administration routes involving the respiratory tract: intratracheal and intranasal instillation. To investigate the biodistribution of CMIT/MIT, we quantified the uptake of 14C-labeled CMIT/MIT in experimental animals for up to seven days after intratracheal and intranasal instillation. In the toxicity study, lung injury was assessed in mice using total inflammatory cell count in bronchoalveolar lavage fluid (BALF) and lung histopathology. The results of the biodistribution study indicated that CMIT/MIT were rapidly distributed throughout the respiratory tract. Using quantitative whole-body autoradiogram analysis, we confirmed that following intranasal exposure, CMIT/MIT reached the lungs via the respiratory tract (nose-trachea-lung). After 5 min post intratracheal and intranasal instillation, the amount of radiotracer ([14C]CMIT/MIT) in the lungs was 2720 ng g-1 and 752 ng g-1 tissue, respectively, and lung damage was observed. A higher amount of the radiotracer resulted in higher toxicity. Both intratracheal and intranasal instillation of CMIT/MIT increased inflammatory cell counts in the BALF and induced injuries in the alveoli. The frequency and the severity scores of injuries caused by intratracheal instillation were approximately-four to five times higher than those induced by intranasal instillation. Therefore, we concluded that CMIT/MIT could reach the lungs following nasal and intratracheal exposure and cause lung injuries, and the extent of injury was dependent on the exposure dose. | Jeon, Jongho; Lee, Kyuhong; Song, Mi-Kyung; Park, Jung Eun; Ryu, Seung-Hun; Baek, Yong-Wook; Kim, Young-Hee; Kim, Dong Im; Yoon, Sung-Hoon; Shin, Hyunil | Korea Inst Toxicol, Inhalat Toxicol Ctr Airborne Risk Factor, 30 Baehak1 gil, Jeonrabugdo 56212, South Korea; Univ Sci & Technol, Dept Human & Environm Toxicol, 217 Gajeong ro, Daejeon 34113, South Korea; Kyungpook Natl Univ, Coll Engn, Dept Appl Chem, 80 Daehak ro, Daegu 41566, South Korea; Natl Inst Environm Res, Humidifier Disinfectant Hlth Ctr, Environm Hlth Res Dept, Hwangyong ro 42, Incheon 22689, South Korea; KRCC Co Ltd, 20 Neunganmal 2 gil, Seoul 06801, South Korea | SHIN, HYUNIL/HOH-1108-2023; Ryu, Seung-Hun/HOC-6552-2023 | 42262783500; 57970194100; 57928816900; 57192364067; 55699593700; 57211851138; 56918955700; 57928786800; 35082028100; 56239790200 | jeonj@knu.ac.kr;khlee@kitox.re.kr; | ENVIRONMENT INTERNATIONAL | ENVIRON INT | 0160-4120 | 1873-6750 | 170 | SCIE | ENVIRONMENTAL SCIENCES | 2022 | 11.8 | 6.0 | 0.7 | 2025-06-25 | 11 | 11 | Chloromethylisothiazolinone; Methylisothiazolinone; Biodistribution; Radiolabeling; Quantitative whole-body autoradiography; Lung injury | DRUG-DELIVERY; DEPOSITION; PAINT | Biodistribution; Chloromethylisothiazolinone; Lung injury; Methylisothiazolinone; Quantitative whole-body autoradiography; Radiolabeling | Animals; Humans; Lung Injury; Mice; Tissue Distribution; Additives; Biological organs; Mammals; Radiography; 2 methyl 4 isothiazolin 3 one; chloromethylisothiazolinone; tracer; unclassified drug; Biodistributions; Chloromethylisothiazolinone; Intranasal; Intratracheal; Lung injury; Methylisothiazolinone; Quantitative whole-body autoradiography; Radiolabelling; Respiratory tract; Whole-body; additive; chemical compound; dose-response relationship; health geography; injury; pesticide; quantitative analysis; respiration; respiratory disease; toxicity; tracer; animal experiment; animal model; animal tissue; Article; bronchoalveolar lavage fluid; controlled study; drug distribution; histopathology; limit of quantitation; lung alveolus; lung toxicity; male; mass spectrometry; mouse; nonhuman; proton nuclear magnetic resonance; quantitative analysis; radiochemistry; radiolabeling; whole body autoradiography; animal; human; lung injury; tissue distribution; Toxicity | English | 2022 | 2022-12 | 10.1016/j.envint.2022.107643 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Blockchain based energy trading scheme for vehicle-to-vehicle using decentralized identifiers | A blockchain-based energy trading system is a new paradigm of grid infrastructure, which allows that energy purchaser and seller can efficiently exchange the energy through two-way communication. However, because energy trading services are provided through public networks, these systems are vulnerable to potential security breaches. This paper proposed a privacy-preserving blockchain-based energy trading scheme for vehicle-to-vehicle to resolve the security issues of contemporary systems and provide secure energy trading services. The proposed scheme has high efficiency by applying decentralized identifiers and verifiable credentials technologies because the records of energy trading are not stored on blockchain and blockchain is only utilized in the validation of users. After completing the energy trading, the vehicle issues a verifiable credential to the counterpart to prove the legitimacy of the transaction. We also perform informal and formal security analysis to demonstrate its security and achieve secure mutual authentication, confidentiality, and session key security. Furthermore, we implement AVISPA simulation to show that our scheme is resistant to man-in-the-middle and replay attacks. As a result, the proposed scheme can be used in distributed smart grid environments. | Kim, Myeonghyun; Lee, Joonyoung; Oh, Jihyeon; Park, Kisung; Park, Youngho; Park, Kilhoum | Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea; Elect & Telecommun Res Inst, Blockchain Technol Res Ctr, Daejeon 34129, South Korea; Kyungpook Natl Univ, Sch Elect Engn, Daegu 41566, South Korea | ; Park, Kisung/KIG-3849-2024 | 57210278739; 57203970123; 57222066296; 57194833768; 56962990300; 35776805000 | kimmyeong123@knu.ac.kr;harry250@knu.ac.kr;chldlstnr071@knu.ac.kr;ks.park@etri.re.kr;parkyh@knu.ac.kr;khpark@ee.knu.ac.kr; | APPLIED ENERGY | APPL ENERG | 0306-2619 | 1872-9118 | 322 | SCIE | ENERGY & FUELS;ENGINEERING, CHEMICAL | 2022 | 11.2 | 6.0 | 3.33 | 2025-06-25 | 32 | 49 | Energy trading; Decentralized identifier; Blockchain; Verifiable credential | AUTHENTICATION PROTOCOL; SECURE; SYSTEM; INTERNET; DESIGN; PEER | Blockchain; Decentralized identifier; Energy trading; Verifiable credential | Power markets; Vehicles; Block-chain; Decentralised; Decentralized identifier; Energy; Energy trading; Grid infrastructures; Trading services; Trading systems; Vehicle to vehicles; Verifiable credential; communication; instrumentation; simulation; smart grid; transport vehicle; Blockchain | English | 2022 | 2022-09-15 | 10.1016/j.apenergy.2022.119445 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
페이지 이동: