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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | Article | CHARACTERIZATION AND IN VITRO SCREENING OF DIFFERENT ENDOPHYTIC FUNGI ON RICE FOR GROWTH PROMOTION UNDER HEAVY METAL STRESS | Continued industrialization around the world has resulted in major threats to agricultural soil. Soil contaminated with heavy metals is a primary challenge for crop production. Their complete removal from the soil is needed. However, the use of plant growth-promoting microbes might mitigate the adverse effects of HMs in crop plants and can be used as a bioremediation tool. In the present study, the tolerance of different endophytic fungi against two different concentrations of cadmium and chromium was investigated. For the purpose, isolated endophytes were screened on Oryza sativa L. seedlings. The results revealed that out of 29 fungal isolates, 4 strains inhibited the plant growth, while remaining were growth-promoting. Of the growth-promoting strains, best results were shown by endophytes, Ch-01 (Aspergillus flavus) and Ch-06 (Aspergillus violaceofirscus), isolated from chilli and Cu-02 (Aspergillus fumigatus), Cu-10 (Aspergillus awamori) and Cu-17 (Aspergillus niger), isolated from Cucurbita. Their association with 0. saliva not only showed an enhancement in growth attributes under Cd and Cr stress, but also resulted in a declined accumulation of Cd and Cr content in 0. saliva seedlings. From the results, it is concluded that A. flavus, A. violaceofuscus, A. fumigatus, A. awamori and A. niger are plant growth-promoting and HMs resistant endophytes, which can significantly improve plant growth in Cd and Cr polluted soils. Hence, these endophytes can be used as biofertilizer in fields affected by heavy metals. | Aziz, Laila; Hamayun, Muhammad; Rauf, Mamoona; Gul, Humaira; Arif, Muhammad; Iqbal, Amjad; Gul, Sarah; Bibi, Hamida; Rehman, Khushnood Ur; Lee, In-Jung | Abdul Wali Khan Univ, Dept Bot, Garden Campus, Mardan 23200, Pakistan; Abdul Wali Khan Univ, Dept Biotechnol, Garden Campus, Mardan 23200, Pakistan; Abdul Wali Khan Univ Mardan, Dept Food Sci & Technol, Mardan, Pakistan; Int Islamic Univ, Dept Biol Sci, FBAS, Islamabad, Pakistan; Univ Agr Peshawar, Dept Soil & Environm Sci, Peshawar, Pakistan; Islamia Coll Univ Peshawar, Dept Bot, Peshawar, Pakistan; Kyungpook Natl Univ, Sch Appl Biosci, Daegu 41566, South Korea | Lee, In-Jung/GLS-0432-2022; Iqbal, Amjad/E-2010-2014; Arif, Muhammad/GNM-5831-2022; Ur Rehman, Khushnood/AAZ-1451-2021; Rauf, Mamoona/AAC-3246-2019; Hamayun, Muhammad/B-1694-2010; rauf, mamoona/AAC-3246-2019 | ijlee@knu.ac.kr; | FRESENIUS ENVIRONMENTAL BULLETIN | 1018-4619 | 1610-2304 | 31 | 1 | 4 | Rice; Oryza saliva; endophytes; heavy metals; chromium; cadmium | PLANTS | English | 2022 | 2022 | 바로가기 | ||||||||||||||||||
| ○ | Article | Characterization of a 20-inch Micro Channel Plate Photomultiplier Tube | There is a proposal to construct a large neutrino detector in Korea, called Korean Neutrino Observatory (KNO), which consists of a large water tank and several tens of thousands of photosensors placed deep underground for neutrino detection. A 20-inch-diameter photosensor including a microchannel plate-photomultiplier Tube (MCP-PMT) is a candidate for the KNO due to its large photo-coverage. We characterized a 20-inch MCP-PMT by measuring its properties, including single photoelectron charge resolution, gain, signal-to-noise performance, dark count rate, after-pulse ratio, and timing performance. We present our measurements of its properties and compare them with those of a previous study. © 2022 The Korean Physical Society. All rights reserved. | Kim, Geonwoo; Lee, Jik; Kim, Hongjoo | Department of Physics, Kyungpook National University, Daegu, 41566, South Korea; Department of Physics, Kyungpook National University, Daegu, 41566, South Korea; Department of Physics, Kyungpook National University, Daegu, 41566, South Korea | 57930451400; 36835827400; 59051568100 | hongjoo@knu.ac.kr; | New Physics: Sae Mulli | 0374-4914 | 72 | 6 | 0 | 2025-06-25 | 0 | After-pulse ratio; Dark count rate; Gain; Korean neutrino observatory; Microchannel plate-photomultiplier tube; Neutrino; Photomultiplier tube | English | Final | 2022 | 10.3938/npsm.72.436 | 바로가기 | 바로가기 | ||||||||||||||||
| ○ | Article | Characterization of a lytic phage KFS-EC3 infecting multiple foodborne pathogens | The purpose of this study was to characterize lytic and genomic properties of phage KFS-EC3 used as a biocontrol agent. The morphology of KFS-EC was observed by transmission electron microscopy (TEM). The polyvalent bactericidal activity of KFS-EC3 was determined against various host bacteria by enumerating bacterial number after phage treatment at multiplicities of infection (MOIs) of 0.001, 0.1, and 1.0 for 4 h. Finally, whole-genome sequencing was performed and annotated to identify its lytic property, safety, and novelty. TEM observation revealed that KFS-EC had morphology of myophage with an icosahedral head and contractile tail. In addition, KFS-EC3 could reduce E. coli, The Salmonella, Shigella sonnei, and their bacterial cocktail by ~3 log CFU/mL, even at the lowest MOI of 0.001. The genomic analyses revealed that KFS-EC3 consisted of 167,440 bp and 151 functional genes, without any genes related to antibiotic resistance, virulence, allergenicity, and lysogenicity. Among the genes involved in host cell lysis, endolysin, holin, and a receptor binding protein were identified. Furthermore, KFS-EC3 was classified into a new phage of the Tequatrovirus genus in the Myoviridae family. In conclusion, lytic and safe phage KFS-EC3 with a broad host range can be used as a biocontrol agent to control foodborne pathogens. Copyright © 2022 The Korean Society of Food Preservation. | Kim, Su-Hyeon; Park, Ye-Rim; Jung, Hyeju; Park, Mi-Kyung | School of Food Science and Biotechnology, Kyungpook National University, Daegu, 41566, South Korea, Food and Bio-Industry Research Institute, Kyungpook National University, Daegu, 41566, South Korea; School of Food Science and Biotechnology, Kyungpook National University, Daegu, 41566, South Korea, Food and Bio-Industry Research Institute, Kyungpook National University, Daegu, 41566, South Korea; School of Food Science and Biotechnology, Kyungpook National University, Daegu, 41566, South Korea, Food and Bio-Industry Research Institute, Kyungpook National University, Daegu, 41566, South Korea; School of Food Science and Biotechnology, Kyungpook National University, Daegu, 41566, South Korea, Food and Bio-Industry Research Institute, Kyungpook National University, Daegu, 41566, South Korea | 57217051011; 58102194600; 57226788607; 7404491155 | parkmik@knu.ac.kr; | Korean Journal of Food Preservation | 1738-7248 | 29 | 7 | 0.18 | 2025-06-25 | 2 | broad host range; genomic analysis; lytic phage; novelty; safety | English | Final | 2022 | 10.11002/kjfp.2022.29.7.1022 | 바로가기 | 바로가기 | ||||||||||||||||
| ○ | Article | Charge Storage Behavior of the Carbons Derived from Polyvinylidene Chloride-resin and Polyvinylidene Fluoride in Different pH Electrolytes | Two polymer precursors, polyvinylidene chloride-resin (PVDC-resin) and polyvinylidene fluoride (PVDF), are assembled into the microporous carbon by pyrolysis. Microporous carbon is advantageous as an electrode for supercapacitors that store electric charges through ion adsorption/desorption. The pyrolysis also turns the various heteroatoms of two precursors into functional groups, contributing to the additional charge storage. The analysis of the porous structure and function group during carbonization are important to develop the carbon for energy storage. Here, we analyzed the functional groups of two polymer-derived carbons through X-ray photoelectron spectroscopy. The electrochemical properties of the functional groups were explored in various pH electrolytes. The specific capacitance of two carbons in the acidic electrolyte (1 M H2SO4) was improved compared to that in the neutral electrolyte (0.5 M Na2SO4) due to the faradaic charge/discharge reaction of the quinone functional group. In particular, the carbon electrode derived from PVDC-resin exhibits a lower capacity than the carbon from PVDF due to the small micropores. In the alkaline electrolyte (6 M KOH), the highest specific capacitance and rate capability were obtained among the three electrolytes for both electrodes based on the facile adsorption of the constituent electrolyte ions (K+, OH-). | Chun, Sang-Eun | Kyungpook Natl Univ, Sch Mat Sci & Engn, Daegu, South Korea; Kyungpook Natl Univ, Dept Hydrogen & Renewable Energy, Daegu 41566, South Korea | Sangeun@knu.ac.kr; | COMPOSITES RESEARCH | COMPOS RES | 2288-2103 | 2288-2111 | 35 | 6 | ESCI | MATERIALS SCIENCE, COMPOSITES | 2022 | 0.3 | 0 | Polyvinylidene fluoride-resin (PVDF-resin); Polytetrafluoroethylene (PTFE); (Micropore); Na2SO4, H2SO4, KOH | OXYGEN FUNCTIONAL-GROUPS; ACTIVATION-FREE METHOD; SURFACE; PERFORMANCE; DESIGN | English | 2022 | 2022-12 | 10.7234/composres.2022.35.6.394 | 바로가기 | 바로가기 | 바로가기 | |||||||||||
| ○ | ○ | Proceedings Paper | Chen-Ricci inequalities for Riemannian maps and their applications | Riemannian maps between Riemannian manifolds, originally introduced by A.E. Fischer in [Contemp. Math. 132 (1992), 331-366], provide an excellent tool for comparing the geometric structures of the source and target manifolds. Isometric immersions and Riemannian submersions are particular examples of such maps. In this work, we first prove a geometric inequality for Riemannian maps having a real space form as a target manifold. Applying it to the particular case of Riemannian submanifolds, we recover a classical result, obtained by B.-Y. Chen in [Glasgow Math. J. 41 (1999), 33-41], which nowadays is known as the Chen-Ricci inequality. Moreover, we extend this inequality in case of Riemannian maps with a complex space form as a target manifold. We also improve this inequality when the Riemannian map is Lagrangian. Applying it to Riemannian submanifolds, we recover the improved Chen-Ricci inequality for Lagrangian submanifolds in a complex space form, that is a basic inequality obtained by S. Deng in [Int. Electron. Electron. J. Geom. 2 (2009), 39-45] as an improvement of a geometric inequality stated by B.-Y. Chen in [Arch. Math. (Basel) 74 (2000), 154-160]. | Lee, Jae Won; Lee, Chul Woo; Sahin, Bayram; Vilcu, Gabriel-Eduard | Gyeongsang Natl Univ, Dept Math Educ, Jinju 52828, South Korea; RINS, Jinju 52828, South Korea; Kyungpook Natl Univ, Dept Math, Daegu 41566, South Korea; Ege Univ, Dept Math, Izmir, Turkey; Petr Gas Univ Ploiesti, Dept Cybernet Econ Informat Finance & Accountancy, BD Bucuresti Nr 39, Ploiesti 100680, Romania; Univ Bucharest, Fac Math & Comp Sci, Res Ctr Geometry Topol & Algebra, Str Acad,Nr 14,Sect 1, Bucharest, Romania | Vilcu, Gabriel-Eduard/AAB-9005-2019; Sahin, Bayram/AAG-7872-2021 | 55917980500; 56100882300; 8411354100; 15081584300 | leejaew@gnu.ac.kr;mathisu@knu.ac.kr;bayram.sahin@ymail.com;gvilcu@upg-ploiesti.ro; | DIFFERENTIAL GEOMETRY AND GLOBAL ANALYSIS: IN HONOR OF TADASHI NAGANO | 0271-4132 | 1098-3627 | 777 | 4.24 | 2025-06-25 | 8 | 8 | Riemannian map; isometric immersion; horizontal space; Chen-Ricci inequality; complex space form | LAGRANGIAN SUBMANIFOLDS; SLANT SUBMANIFOLDS; CURVATURE; CLASSIFICATION; SUBMERSIONS; THEOREMS | Chen-Ricci inequality; complex space form; horizontal space; isometric immersion; Riemannian map | English | 2022 | 2022 | 10.1090/conm/777/15627 | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | Article | Chronic Recurrent Multifocal Osteomyelitis Associated With Inflammatory Bowel Disease Successfully Treated With Infliximab | Chronic recurrent multifocal osteomyelitis (CRMO) is an inflammatory bone disorder presenting with sterile osteomyelitis, most often presenting in childhood. Although the etiology is understood incompletely, its association with other auto-inflammatory diseases including inflammatory bowel disease (IBD); psoriasis; Wegener’s disease; arthritis; and synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome suggests that dysregulated innate immunity may play an important role in the pathogenesis. We report a case of a 13-year-old boy with CRMO associated with Crohn’s disease (CD) successfully treated with infliximab after failure of non-steroidal anti-inflammatory drug (NSAID) treatment. He initially was diagnosed with CRMO based on symmetric and aseptic bone lesions with no fever, lack of response to antibiotic treatment, vertebral involvement, and normal blood cell counts. Despite five months of NSAID treatment, his musculoskeletal symptoms were aggravated, and he developed gastrointestinal symptoms. Finally, he was diagnosed with CRMO associated with CD. Due to the severity of symptoms, infliximab was initiated and produced symptom improvement. This case supports infliximab as another choice for treatment of bowel symptoms in addition to the bone and joint symptoms of CRMO when other first-line treatments are ineffective. © 2022 The Korean Society of Pediatric Infectious Diseases. | Kwak, Shinhyeung; Kim, Dongsub; Choi, Joon-Sik; Yoon, Yoonsun; Kim, Eun Sil; Kim, Mi Jin; Yoo, So-Young; Shim, Jong Sup; Choe, Yon Ho; Kim, Yae-Jean | Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, Department of Pediatrics, Kyungpook National University School of Medicine, Daegu, South Korea; Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, Department of Pediatrics, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, South Korea; Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, Department of Pediatrics, College of Medicine, Korea University, Seoul, South Korea; Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; Department of Orthopedic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea | 57305936500; 57205248455; 57205245521; 57217112409; 57205500267; 56638815200; 57074859700; 55664083300; 21333712100; 7410198066 | yaejeankim@skku.edu; | Pediatric Infection and Vaccine | 2384-1079 | 29 | 2 | 0 | 2025-06-25 | 0 | Chronic recurrent multifocal osteomyelitis; Crohn’s disease; Inflammatory bowel disease; Infliximab | albumin; azathioprine; C reactive protein; calgranulin; immunoglobulin; infliximab; mesalazine; naproxen; nonsteroid antiinflammatory agent; nutrition supplement; abdominal pain; abscess; adolescent; anemia of chronic disease; ankle pain; antibiotic therapy; arthralgia; Article; blood cell count; bone lesion; bone pain; bone scintiscanning; case report; chronic recurrent multifocal osteomyelitis; clinical article; colon ulcer; colonoscopy; contracture; Crohn disease; Crohn Disease Activity Index; diarrhea; erythrocyte sedimentation rate; femur; follow up; foot pain; gastrointestinal endoscopy; gastrointestinal symptom; human; incision; inflammatory bowel disease; iron deficiency; knee pain; magnetic resonance enterography; male; malleolus; medical history; multiple cycle treatment; musculoskeletal disease; nuclear magnetic resonance; orthopedic surgery; osteomyelitis; postoperative complication; psoriasis; rheumatoid arthritis; sclerosis; swelling; tenosynovitis; tibia | English | Final | 2022 | 10.14776/piv.2022.29.e14 | 바로가기 | 바로가기 | |||||||||||||||
| ○ | Article | Cisplatin-Induced Ototoxicity: Updates on Potential Molecular Mechanism | Cis-diamminedichloroplatinum(II) (cisplatin), platinum compound, is an anti-cancer agent currently used for the treatment of a number of human solid cancers. It irreversibly reacts with DNA to form an interconnection between guanine-group helices, resulting in cell death. Furthermore, it is also associated with numerous adverse effects such as nephrotoxicity, neurotoxicity, and ototoxicity. Hearing loss due to cisplatin ototoxicity is usually permanent and bilateral. Many studies have been conducted on the ototoxicity of cisplatin, however, its pathology and treatment have not been fully elucidated. Studies have reported that cisplatin inhibits the action of adenylate cyclase in the stria vascularis, and hearing loss occurs due to a decrease in the receptor current of the outer hair cells. In addition, it has been reported that morphological changes in the inner ear include changes in outer hair cells and abnormal findings in the supporting cells of the organ of Corti and Reissner’s membrane. Oxidative stress is known to be the main cause of ototoxicity. In addition, it has recently been suggested that inflammation may trigger inner ear cell death through autophagy, necrosis, and endogenous apoptosis. In this review, we intend to provide a basis for the prevention strategy of cisplatin-induced ototoxicity by revealing its molecular targets and intracellular pathways. Copyright© 2022 Korean Society of Otorhinolaryngology-Head and Neck Surgery | Jung, Da Jung | Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Kyungpook National University, Daegu, South Korea | 57220970862 | wjddk0731@naver.com; | Korean Journal of Otorhinolaryngology-Head and Neck Surgery | 2092-6529 | 65 | 10 | 0.22 | 2025-06-25 | 1 | Cisplatin; Mechanism; Ototoxicity | Korean | Final | 2022 | 10.3342/kjorl-hns.2022.00507 | 바로가기 | 바로가기 | ||||||||||||||||
| ○ | ○ | Article | Classification of the extreme points of Ls (2l3∞) by computation | Let l3 infinity = R3 be endowed with the supremum norm. In [Comment. Math. 2017, 57 (1), 1-7], S.G. Kim classified the extreme points of the unit ball of Ls(2l3 infinity) only using Mathematica 8, where Ls(2l3 infinity) is the space of symmetric bilinear forms on l3 infinity. It seems to be interesting and meaningful to classify the extreme points of the unit ball of Ls(2l3 infinity) without using Mathematica 8. The aim of this paper is to make such classification by mathematical calculations. | Guen, Kim Sung | Kyungpook Natl Univ, Dept Math, Daegu 41566, South Korea | 34769667700 | sgk317@knu.ac.kr; | CARPATHIAN MATHEMATICAL PUBLICATIONS | CARPATHIAN MATH PUBL | 2075-9827 | 2313-0210 | 14 | 2 | ESCI | MATHEMATICS | 2022 | 0.8 | 0 | 2025-06-25 | 0 | 0 | extreme point | EXPOSED 2-HOMOGENEOUS POLYNOMIALS; UNIT BALL; BILINEAR-FORMS; MULTILINEAR FORMS; HOMOGENEOUS POLYNOMIALS; SMOOTH POINTS; GEOMETRY; SPACES; POLARIZATION | extreme point | English | 2022 | 2022 | 10.15330/cmp.14.2.371-387 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | Article | Clinical and Subclinical Cases of Canine Babesiosis Caused by Babesia gibsoni in the Republic of Korea | Canine babesiosis has been scarcely investigated in the Republic of Korea (ROK). Although it is known that Babesia gibsoni is its primary causative agent, its clinical presentation has not been completely clarified in the ROK. Consequently, the aim of this study was to evaluate the clinical appearance of this parasitic infection based on the anamnesis of the patient and compare of hematological and biochemical test results. Four hundred whole blood samples from patients with a presumptive diagnosis of tick-borne disease were analyzed by polymerase chain reaction (PCR) to amplify the Babesia spp. 18S rRNA gene and by a rapid diagnostic test kit (VetAll Laboratories®) to detect B. gibsoni seroreactive animals. Thirty-six (9.0%) dogs were PCR-positive but only 24 (6.0%) were seropositive. The investigation revealed that all the courses of the disease are present in the ROK, with the acute course being predominant. The acute course tends to consist of inappetence, lethargy, pyrexia, gastrointestinal symptoms, and occasionally hematuria. It also occurs with common hematological abnormalities, such as thrombocytopenia and anemia, and to a lesser extent biochemical abnormalities, such as hyperbilirubinemia, hypoalbuminemia, and elevated liver enzymes. This research shows that B. gibsoni is an endemic hemoparasite capable of producing a variety of clinical manifestations in dogs. For its accurate diagnosis, a descriptive history of the clinical signs, hematology, and biochemical profile of the patient, along with a well-performing PCR assay, are essential. These findings will help in planning pragmatic preventive strategies against this potent threat in the ROK. © The Korean Society of Veterinary Clinics. | Miranda, Evelyn Alejandra; Han, Sun-Woo; Rim, Ji-Min; Cho, Yoon-Kyoung; Yu, Dohyeon; Choi, Kyoung-Seong; Chae, Joon-Seok | Laboratory of Veterinary Internal Medicine, BK21 FOUR Future Veterinary Medicine Leading Education and Research Center, Research Institute for Veterinary Science and College of Veterinary Medicine, Seoul National University, Seoul, 08826, South Korea; Laboratory of Veterinary Internal Medicine, BK21 FOUR Future Veterinary Medicine Leading Education and Research Center, Research Institute for Veterinary Science and College of Veterinary Medicine, Seoul National University, Seoul, 08826, South Korea; Laboratory of Veterinary Internal Medicine, BK21 FOUR Future Veterinary Medicine Leading Education and Research Center, Research Institute for Veterinary Science and College of Veterinary Medicine, Seoul National University, Seoul, 08826, South Korea; Laboratory of Veterinary Internal Medicine, BK21 FOUR Future Veterinary Medicine Leading Education and Research Center, Research Institute for Veterinary Science and College of Veterinary Medicine, Seoul National University, Seoul, 08826, South Korea; College of Veterinary Medicine, Gyeongsang National University, Jinju, 52828, South Korea; College of Ecology and Environmental Science, Kyungpook National University, Sangju, 37224, South Korea; Laboratory of Veterinary Internal Medicine, BK21 FOUR Future Veterinary Medicine Leading Education and Research Center, Research Institute for Veterinary Science and College of Veterinary Medicine, Seoul National University, Seoul, 08826, South Korea | 57221444863; 57216636732; 57226753955; 57201634305; 14623495400; 7403949556; 7102478039 | jschae@snu.ac.kr; | Journal of Veterinary Clinics | 1598-298X | 39 | 5 | 0.65 | 2025-06-25 | 3 | Babesia gibsoni; canine babesiosis; dog; PCR; seroprevalence | alanine aminotransferase; anticoagulant agent; aspartate aminotransferase; atovaquone; azithromycin; hemoglobin; animal experiment; Article; Babesia gibsoni; blood cell count; blood sampling; blood transfusion; bootstrapping; canine babesiosis; clinical evaluation; controlled study; diagnostic test accuracy study; DNA extraction; DNA sequencing; dog; gene amplification; leukocyte count; loss of appetite; multiple sequence alignment; nonhuman; nucleotide sequence; parasitosis; phylogenetic tree; phylogeny; platelet count; polymerase chain reaction; sensitivity and specificity; sequence alignment; serology; seroprevalence; urea nitrogen blood level | English | Final | 2022 | 10.17555/jvc.2022.39.5.207 | 바로가기 | 바로가기 | |||||||||||||||
| ○ | ○ | Article | Clinical Characteristics of the Eye with Fuch's Corneal Endothelial Dystrophy after Descemet Stripping Only | Purpose: To report the effect of removal of a central descemet membrane on the endothelial function, morphology, and clinical symptoms of eyes with Fuch's endothelial dystrophy. Methods: From August 2019 to January 2021, patients with Fuch's endothelial dystrophy, i.e., with confluent, central corneal gut tae and cataracts that required surgery, underwent phacoemulsification, intraocular lens implantation, and central descemet membrane stripping. To evaluate the effect of descemet stripping only (DSO), visual acuity and intraocular pressure were measured, and corneal pachymetry, slit-lamp and specular microscopy, and anterior segment optical coherence tomography performed, before surgery and at 1, 7, and 30 days and 3 and 6 months after surgery. Results: Seven patients (10 eyes) were included. Visual acuity improved from 1.01 +/- 0.40 logarithm of the minimum angle of resolution (logMAR) preoperatively to 0.33 +/- 0.22 logMAR 6 months after surgery (p = 0.008). The mean central corneal thickness decreased from 578.50 +/- 36.88 mu m preoperatively to 568.50 +/- 48.61 mu m 6 months after surgery; the difference was not significant (p = 0.507). The endothelial cell count increased significantly from 663.80 +/- 356.40/mm(2) preoperatively to 1,082.00 +/- 274.46/mm(2) 6 months after surgery (p = 0.043). Conclusions: DSO can serve as a useful alternative when corneal transplantation is not possible in patients with Fuch's endothelial dystrophy, but treatment efficacy and safety require further evaluation. | Yae, Che Gyem; Jung, Jae Uk; Park, Mi Hwa; Jo, Yeong Chae; Kim, Hong Kyun | Kyungpook Natl Univ, Sch Med, Dept Ophthalmol, 680 Gukchaebosang Ro, Daegu 41944, South Korea | Jung, Jiung/F-5829-2017 | 56048982200; 57204707632; 57476818400; 57219775443; 57218260940 | okeye@knu.ac.kr; | JOURNAL OF THE KOREAN OPHTHALMOLOGICAL SOCIETY | J KOR OPHTHALMOL SOC | 0378-6471 | 2092-9374 | 63 | 6 | ESCI | OPHTHALMOLOGY | 2022 | 0.1 | 0 | 2025-06-25 | 0 | 0 | Descemet stripping only; Descemetorhexis without endothelial keratoplasty; Fuchs' dystrophy | KERATOPLASTY | Descemet stripping only; Descemetorhexis without endothelial keratoplasty; Fuchs' dystrophy | Korean | 2022 | 2022-06 | 10.3341/jkos.2022.63.6.519 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Clinical impact of spine magnetic resonance imaging as a valuable prognostic tool for patients with multiple myeloma: a retrospective study | Background: This study investigated the prognostic impact of spine magnetic resonance imaging (MRI) in patients newly diagnosed Methods: We retrospectively evaluated 214 patients who were newly diagnosed with MM between March 2015 and December 2019. The patients were classified into five different infiltration patterns based on spine MRI as follows: (1) normal appearance, (2) focal, (3) diffuse, (4) combined focal and diffuse infiltration, and (5) "salt-and-pepper." Results: Forty patients (18.7%) showed a normal appearance, whereas focal, diffuse, combined focal and diffuse infiltration, and "saltand-pepper" patterns were identified in 68 (31.8%), 40 (18.7%), 52 (24.3%), and 14 patients (6.5%), respectively. The patients with normal and "salt-and-pepper" patterns were younger than patients with other patterns (median age, 61.6 vs. 66.8 years; p=0.001). Moreover, 63% and 59.3% of patients with normal and "salt-and-pepper" patterns were scored International Staging System (ISS) stage I and revised ISS (R-ISS) stage I, respectively, whereas only 12.5% of patients with other patterns were scored ISS stage I and R-ISS stage I. Patients with normal and "salt-and-pepper" patterns had a better prognosis than those with other patterns, whereas relapse and death rates were significantly higher in patients with focal, diffuse, and combined MRI patterns.Conclusion: Characteristic MRI findings have a significant prognostic value for long-term survival in patients newly diagnosed with MM. In particular, focal, diffuse, and combined focal and diffuse infiltration patterns are unfavorable prognostic factors. | Lee, Jung Min; Cho, Hee Jeong; Moon, Joon-Ho; Sohn, Sang Kyun; Park, Byunggeon; Baek, Dong Won | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Hematol Oncol, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Radiol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Kyungpook Natl Univ Hosp, Dept Hematol Oncol, 130 Dongdeok Ro, Taegu 700721, South Korea | ; Lee, Jungmin/KHT-2438-2024 | 57211561890; 57216754907; 56568642700; 13310226800; 57211532915; 57191874272 | baekdw83@gmail.com; | JOURNAL OF YEUNGNAM MEDICAL SCIENCE | 2799-8010 | 39 | 4 | 0.14 | 2025-06-25 | 2 | 2 | Hematopoietic stem cell transplantation; Magnetic resonance imaging; Multiple myeloma; Prognosis | BONE-MARROW; WHOLE-BODY; DIAGNOSIS; THERAPY; DISEASE; MRI; TRANSPLANTATION; DEXAMETHASONE; CHEMOTHERAPY; BORTEZOMIB | Hematopoietic stem cell transplantation; Magnetic resonance imaging; Multiple myeloma; Prognosis | English | 2022 | 2022 | 10.12701/jyms.2021.01648 | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | ○ | Article | Clinical implication of adjuvant chemotherapy according to mismatch repair status in patients with intermediate-risk stage II colon cancer: a retrospective study | Background: The present study evaluated the clinical implications of adjuvant chemotherapy according to the mismatch repair (MMR) status and clinicopathologic features of patients with intermediate-and high-risk stage II colon cancer (CC).Methods: This study retrospectively reviewed 5,774 patients who were diagnosed with CC and underwent curative surgical resection at Kyungpook National University Chilgok Hospital. The patients were enrolled according to the following criteria: (1) pathologically diagnosed with primary CC; (2) stage II CC classified based on the 7th edition of the American Joint Committee on Cancer staging system; (3) intermediate-and high-risk features; and (4) available test results for MMR status. A total of 286 patients met these criteria and were included in the study.Results: Among the 286 patients, 54 (18.9%) were identified as microsatellite instability-high (MSI-H) or deficient MMR (dMMR). Although all the patients identified as MSI-H/dMMR showed better survival outcomes, T4 tumors and adjuvant chemotherapy were identified as independent prognostic factors for survival. For the intermediate-risk patients identified as MSI-low (MSI-L)/microsatellite stable (MSS) or proficient MMR (pMMR), adjuvant chemotherapy exhibited a significantly better disease-free survival (DFS) but had no impact on overall survival (OS). Oxaliplatin-containing regimens showed no association with DFS or OS. Adjuvant chemotherapy was not associated with DFS in intermediate-risk patients identified as MSI-H/dMMR.Conclusion: The current study found that the use of adjuvant chemotherapy was correlated with better DFS in MSI-L/MSS or pMMR intermediate-risk stage II CC patients. | Kang, Byung Woog; Baek, Dong Won; Chang, Eunhye; Kim, Hye Jin; Park, Su Yeon; Park, Jun Seok; Choi, Gyu Seog; Baek, Jin Ho; Kim, Jong Gwang | Kyungpook Natl Univ, Kyungpook Natl Univ Chilgok Hosp, Kyungpook Natl Univ Canc Res Inst, Sch Med,Dept Oncol Hematol, 807 Hoguk Ro, Daegu 41404, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Chilgok Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Chilgok Hosp, Sch Med, Dept Surg, Daegu, South Korea | ; Kim, Hye/W-1059-2019; Park, Joonhong/AAZ-9885-2020 | 28567838500; 57191874272; 58740218300; 57204567554; 57203275898; 35226761100; 8058759100; 57217075847; 59501049300 | jhbaek@knu.ac.kr;jkk21c@knu.ac.kr; | JOURNAL OF YEUNGNAM MEDICAL SCIENCE | 2799-8010 | 39 | 2 | 0.14 | 2025-06-25 | 1 | 2 | Adjuvant chemotherapy; Colonic neoplasms; DNA mismatch repair; Intermediate risk; Stage II disease | MICROSATELLITE-INSTABILITY; FLUOROURACIL; THERAPY; OXALIPLATIN; LEUCOVORIN; SURVIVAL | Adjuvant chemotherapy; Colonic neoplasms; DNA mismatch repair; Intermediate risk; Stage II disease | English | 2022 | 2022 | 10.12701/yujm.2021.01571 | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | Article | Clinical Implication of KRAS Mutation Variants in Patients With Resected Colon Cancer | Aim: This study evaluated the clinical implication of KRAS proto-oncogene, GTPase (KRAS) mutation variants in patients with resected colon cancer (CC). Patients and Methods: We retrospectively reviewed 482 patients diagnosed with CC who underwent curative surgical resection at Kyungpook National University Chilgok Hospital. The inclusion criteria were: Pathologically diagnosed with primary CC; stage I-III CC according to the 7th edition of American Joint Committee on Cancer staging system; and with available test results for KRAS mutation status. In total, 345 patients met these criteria and were included in this study. Results: Among the 345 patients, 140 (40.6%) exhibited KRAS mutations, with their incidences as follows: 90/140 (64.3%) in exon 2 codon 12, 37/140 (26.4%) in exon 2 codon 13, 1/140 (0.1%) in exon 3 codon 59, 7/140 (5.0%) in exon 3 codon 61, and 5/140 (3.6%) in exon 4 codon 146. KRAS mutation status was not a significant prognostic factor for disease-free survival or overall survival. Although there were no significant differences in survival between patients with exon 2 codon 12 and exon 2 codon 13 mutations, poorer disease-free survival (p=0.085) and overall survival (p=0.005) were seen in those with exon 3 codon 61 mutation than in others. Conclusion: KRAS mutation status was not correlated with survival, but exon 3 codon 61 mutation might be a factor for poor prognosis in patients after resection of CC. © 2022 International Institute of Anticancer Research. | Baek, Jin Ho; Kim, Juhyung; Baek, Dong Won; Chang, Eunhye; Kim, Hye Jin; Park, Su Yeon; Park, Jun Seok; Choi, Gyu Seog; Kang, Byung Woog; Kim, Jong Gwang | Department of Oncology/Hematology, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Kyungpook National University Cancer Research Institute, Daegu, South Korea; Department of Oncology/Hematology, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Kyungpook National University Cancer Research Institute, Daegu, South Korea; Department of Oncology/Hematology, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Kyungpook National University Cancer Research Institute, Daegu, South Korea; Department of Internal Medicine, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Daegu, South Korea; Department of Surgery, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Daegu, South Korea; Department of Surgery, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Daegu, South Korea; Department of Surgery, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Daegu, South Korea; Department of Surgery, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Daegu, South Korea; Department of Oncology/Hematology, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Kyungpook National University Cancer Research Institute, Daegu, South Korea; Department of Oncology/Hematology, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Kyungpook National University Cancer Research Institute, Daegu, South Korea | 57217075847; 58739544500; 57191874272; 58740218300; 57204567554; 57203275898; 58950735400; 8058759100; 28567838500; 59501049300 | bwkang@knu.ac.kr;jkk21c@knu.ac.kr; | Cancer Diagnosis and Prognosis | 2732-7787 | 2 | 1 | 0.19 | 2025-06-25 | 2 | Colon cancer; KRAS; PNAClamp™; prognosis | English | Final | 2022 | 10.21873/cdp.10079 | 바로가기 | 바로가기 | ||||||||||||||||
| ○ | ○ | Article | Clinical outcomes and predictors of response for adalimumab in patients with moderately to severely active ulcerative colitis: a KASID prospective multicenter cohort study | Background/Aims: This study assessed the efficacy and safety of adalimumab (ADA) and explored predictors of response in Korean patients with ulcerative colitis (UC). Methods: A prospective, observational, multicenter study was conducted over 56 weeks in adult patients with moderately to severely active UC who received ADA. Clinical response, remission, and mucosal healing were assessed using the Mayo score. Results: A total of 146 patients were enrolled from 17 academic hospitals. Clinical response rates were 52.1% and 37.7% and clinical remission rates were 24.0% and 22.0% at weeks 8 and 56, respectively. Mucosal healing rates were 39.0% and 30.1% at weeks 8 and 56, respectively. Prior use of anti-tumor necrosis factor-alpha (anti-TNF-alpha) did not affect clinical and endoscopic responses. The ADA drug level was significantly higher in patients with better outcomes at week 8 (P< 0.05). In patients with lower endoscopic activity, higher body mass index, and higher serum albumin levels at baseline, the clinical response rate was higher at week 8. In patients with lower Mayo scores and C-reactive protein levels, clinical responses, and mucosal healing at week 8, the clinical response rate was higher at week 56. Serious adverse drug reactions were identified in 2.8% of patients. Conclusions: ADA is effective and safe for induction and maintenance in Korean patients with UC, regardless of prior anti-TNF-alpha therapy. The ADA drug level is associated with the efficacy of induction therapy. Patients with better short-term outcomes were predictive of those with an improved long-term response. (Intest Res, Published online ) | Shin, Seung Yong; Park, Soo Jung; Kim, Young; Im, Jong Pil; Kim, Hyo Jong; Lee, Kang-Moon; Kim, Ji Won; Jung, Sung-Ae; Lee, Jun; Kang, Sang-Bum; Shin, Sung Jae; Kim, Eun Sun; Kim, You Sun; Kim, Tae Oh; Kim, Hyun-Soo; Park, Dong Il; Kim, Hyung Kil; Kim, Eun Soo; Kim, Young-Ho; Kim, Do Hyun; Teng, Dennis; Kim, Jong-Hwa; Kim, Wonyong; Choi, Chang Hwan | Chung Ang Univ, Dept Internal Med, Coll Med, 102 Heukseok Ro, Seoul 06973, South Korea; Yonsei Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Yonsei Univ, Inst Gastroenterol, Coll Med, Seoul, South Korea; Seoul Natl Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Seoul Natl Univ, Liver Res Inst, Coll Med, Seoul, South Korea; Kyung Hee Univ Hosp, Dept Gastroenterol, Seoul, South Korea; Catholic Univ Korea, Dept Gastroenterol, St Vincents Hosp, Suwon, South Korea; SMG SNU Boramae Med Ctr, Dept Gastroenterol, Seoul, South Korea; Ewha Womans Univ, Dept Gastroenterol, Coll Med, Seoul, South Korea; Chosun Univ, Dept Internal Med, Coll Med, Gwangju, South Korea; Catholic Univ Korea, Dept Internal Med, Daejeon St Marys Hosp, Coll Med, Daejeon, South Korea; Ajou Univ, Dept Gastroenterol, Sch Med, Suwon, South Korea; Korea Univ, Dept Gastroenterol, Anam Hosp, Seoul, South Korea; Inje Univ, Dept Gastroenterol, Seoul Paik Hosp, Seoul, South Korea; Inje Univ, Dept Gastroenterol, Haeundae Paik Hosp, Busan, South Korea; Chonnam Natl Univ Hosp, Dept Gastroenterol, Gwangju, South Korea; Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Internal Med, Sch Med, Seoul, South Korea; Inha Univ Hosp, Dept Gastroenterol, Incheon, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Korea, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Internal Med, Sch Med, Seoul, South Korea; AbbVie Ltd, Seoul, South Korea; AbbVie Pte Ltd, Singapore, Singapore; Chung Ang Univ, Dept Microbiol, Coll Med, Seoul, South Korea | Kim, Hanjun/AAJ-7528-2021; Kim, Jong/AAE-4958-2019; Kim, You Sun/B-2881-2015; kim, juhee/HKV-6163-2023; Kim, Jung Bong/KEJ-5743-2024; Kim, Jong-Hwa/AHA-6528-2022; Kim, Sang/J-5398-2012; Kwak, Sang Gyu/AAG-4341-2021; Kim, Seok-Hwan/G-9981-2015; Lee, Jun/AAC-6941-2022; Kim, Hyung/J-5451-2012 | 57202549801; 56042287100; 57215214193; 8108755200; 55363170800; 35196099500; 56063660400; 7403676915; 57202953059; 8837205700; 57221641429; 56308204100; 56565885500; 55603811000; 57210863499; 56524839700; 57941472200; 57203086704; 57210738018; 57788226600; 57787334800; 55917964500; 34770706500; 56799609000; 57833330400 | gicch@cau.ac.kr; | INTESTINAL RESEARCH | INTEST RES | 1598-9100 | 20 | 3 | ESCI | GASTROENTEROLOGY & HEPATOLOGY | 2022 | 4.9 | 1.8 | 2025-06-25 | 17 | 16 | Inflammatory bowel disease; Tumor necrosis factor inhibitors; Treatment outcome | INFLAMMATORY-BOWEL-DISEASE; CROHNS-DISEASE; ENDOSCOPIC REMISSION; NATURAL-HISTORY; THERAPY; EFFICACY; SAFETY; EPIDEMIOLOGY; PHARMACOKINETICS; COMBINATION | Inflammatory bowel disease; Treatment outcome; Tumor necrosis factor inhibitors | English | 2022 | 2022-07 | 10.5217/ir.2021.00049 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Review | Clostridioides Infection in Patients with Inflammatory Bowel Disease | Inflammatory bowel disease (IBD), comprising Crohn's disease and ulcerative colitis, is a chronic inflammatory condition of the gastrointestinal tract, which is often accompanied by altered gut microbial composition. Gut dysbiosis in IBD is considered to be the reason for the high risk of Clostridioides difficile infection (CDI) in patients with IBD. Therefore, CDI should be evaluated in IBD patients with a symptom flare. Medical treatment of non-severe CDI in IBD is similar to that in non-IBD patients and includes oral vancomycin or fidaxomicin. The risk of recurrent CDI in IBD is higher than in non-IBD patients and this could be mitigated by fecal microbiota transplantation. As CDI may worsen the clinical outcomes of IBD, patients should be carefully monitored and an escalation of IBD therapy needs to be considered when there is no improvement seen with the antimicrobial treatment of CDI. This review discusses the risk, pathophysiology, diagnosis, and management of CDI in IBD. | Lee, Mi Rae; Kim, Eun Soo | Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea | ; Kim, Sang/J-5398-2012 | 57859096300; 57203086704 | dandy813@hanmail.net; | KOREAN JOURNAL OF GASTROENTEROLOGY | KOR J GASTROENTEROL | 1598-9992 | 2233-6869 | 80 | 2 | ESCI | GASTROENTEROLOGY & HEPATOLOGY | 2022 | 0.6 | 0 | 2025-06-25 | 0 | 0 | Clostridioides difficile infection; Inflammatory bowel diseases; Colitis; ulcerative; Crohn disease | FECAL MICROBIOTA TRANSPLANTATION; DIFFICILE INFECTION; RISK-FACTORS; IMPACT; OUTCOMES; EPIDEMIOLOGY; METAANALYSIS; MULTICENTER; MANAGEMENT; DIAGNOSIS | Clostridioides difficile infection; Colitis, ulcerative; Crohn disease; Inflammatory bowel diseases | Chronic Disease; Clostridioides difficile; Clostridium Infections; Colitis, Ulcerative; Fecal Microbiota Transplantation; Humans; Inflammatory Bowel Diseases; chronic disease; Clostridium infection; complication; fecal microbiota transplantation; human; inflammatory bowel disease; ulcerative colitis | Korean | 2022 | 2022-08 | 10.4166/kjg.2022.097 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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