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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | Article | A case of anaphylactic shock to ethylenediaminetetraacetic acid as a drug excipient | If drug excipients hypersensitivity is not accurately recognized, the patient is at risk of experiencing repeated hypersensitivity to various drugs. Ethylenediaminetetraacetic acid (edetic acid, EDTA), often found as an excipient in injectable drugs and topical agents. Herein, we report a patient who developed anaphylactic shock to an injection containing EDTA and subsequently experienced both immediate and delayed hypersensitivity reactions to EDTA. A 51-year-old female was referred due to perioperative anaphylaxis. It took the patient 2 hours to return to the ward after receiving general anesthesia. Immediately after returning to the ward, the patient received injections of Mucosten (Medica), Traumeel (Saehan), and Botropase (Han Lim), and within 1 minute she experienced an anaphylactic shock. The patient had drug allergy histories to computed tomography contrast agents and injectable drugs as well as repeated contact dermatitis histories to topical agents. A month later, the patient came to the outpatient clinic. As a result, intradermal test for perioperative drugs, Mucosten, and Dexamethasone (Daewon Pharm) were positive. In addition, the 48-hour delay test for Mucosten and Dexamethasone was also positive. Under the suspicion of additive hypersensitivity, skin prick test was performed for disodium acetate, an additive containing Mucosten and Dexamethasone, which showed a positive result. However, skin prick test for N-Acetyl-L-cysteine, a main compound of Mucosten, was negative. This case is a hypersensitivity reaction to EDTA, which was confirmed by drug skin tests. In addition, this case is meaningful in that immediate and delayed hypersensitivity reactions to a single excipient appeared independently in the same patient. | Park, Han-Ki; Jeong, Yoon-Ho; Park, Bo Eun; Kim, Sujeong; Lee, Jong-Myung | Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Div Allergy & Clin Immunol, Dept Internal Med, Chilgok Hosp, Daegu, South Korea | hann33@gmail.com; | ALLERGY ASTHMA & RESPIRATORY DISEASE | ALLERGY ASTHMA RESPI | 2288-0402 | 2288-0410 | 11 | 2 | ESCI | ALLERGY | 2023 | 0.2 | 91.0 | 0 | Anaphylaxis; Edetic acid; Excipients | IMMEDIATE HYPERSENSITIVITY; CONTACT-DERMATITIS; EDTA; ALLERGY | Korean | 2023 | 2023-04-01 | 10.4168/aard.2023.11.2.110 | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | Article | Associations between pollen and allergic rhinitis in children and adolescents | Allergic rhinitis (AR) is a type of rhinitis accompanied by sensitization to allergens. One of the most clinically important allergens is pollen. Recently, due to climate change and CO2 air pollution, the flowering period starts earlier and persists longer. In addition, antigenicity due to environmental pollution is also being strengthened. As a result, the sensitization rate to pollen antigens is on the rise. It is known that the prevalence of AR especially caused by pollen is rapidly escalating. Although the causal relationship between pollen exposure and the severity of rhinitis is not precisely established, an association of rhinitis symptoms with the time of pollen scattering exists. In addition, the mixed effect of environmental pollution and pollen may play a role in the development of rhinitis symptoms. Therefore, in order to avoid pollen, it is necessary to constantly improve pollen forecast and minimize the contact with pollen indoors and outdoors. Treatment of AR should be performed according to guidelines. Also, continuous efforts to solve the environmental problems affecting the ecology of pollen are needed. | Lee, Kyung Suk; Kim, Minji; Kim, Hyun Hee; Kim, Hyo-Bin; Rha, Yeong-Ho; Park, Yong Mean; Sung, Myongsoon; Sheen, Youn Ho; Yum, Hye Yung; Lee, Yong Ju; Chun, Yoon Hong; Jee, Hye Mi; Choi, Bong Seok; Choi, Sun Hee; Park, Yang | Hanyang Univ, Hanyang Univ Guri Hosp, Coll Med, Dept Pediat, Guri, South Korea; Chungnam Natl Univ, Chungnam Natl Univ Hosp, Coll Med, Dept Pediat, Daejeon, South Korea; Catholic Univ Korea, Coll Med, Dept Pediat, Seoul, South Korea; Inje Univ, Sanggye Paik Hosp, Asthma & Allergy Ctr, Dept Pediat, Seoul, South Korea; Kyung Hee Univ, Sch Med, Dept Pediat, Seoul, South Korea; Konkuk Univ, Konkuk Univ Med Ctr, Sch Med, Dept Pediat, Seoul, South Korea; Soonchunhyang Univ, Gumi Hosp, Dept Pediat, Gumi, South Korea; CHA Univ, CHA Gangnam Med Ctr, Sch Med, Dept Pediat, Seoul, South Korea; Seoul Med Ctr, Dept Pediat, Seoul, South Korea; Yonsei Univ, Yongin Severance Hosp, Coll Med, Dept Pediat, Yongin, South Korea; CHA Univ, Sch Med, CHA Bundang Med Ctr, Dept Pediat, Seongnam, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu, South Korea; Wonkwang Univ, Jangheung Integrat Med Hosp, Dept Pediat, Sch Med, Jangheung, South Korea | Yum, Hye Yung/HNS-1098-2023 | pyallergy@gmail.com; | ALLERGY ASTHMA & RESPIRATORY DISEASE | ALLERGY ASTHMA RESPI | 2288-0402 | 2288-0410 | 11 | 1 | ESCI | ALLERGY | 2023 | 0.2 | 91.0 | 1 | Allergic rhinitis; Pollens; Child; Adolescents | KOREAN CHILDREN; CLIMATE-CHANGE; SENSITIZATION; ABUNDANCE; SYMPTOMS; RAGWEED; TRENDS; PINE | Korean | 2023 | 2023-01 | 10.4168/aard.2023.11.1.3 | 바로가기 | 바로가기 | 바로가기 | |||||||||
| ○ | ○ | Article | A Wide-field-of-view Table-ornament Display Using Electronic Holography | Three-dimensional (3D) displays provide a significant advantage over traditional 2D displays by offering realistic images, and table-style displays in particular are ideal for generating 3D images that appear to float above a table. These systems are based on multiview displays, and are typically operated using temporal or spatial multiplexing methods to expand the viewing zone (VZ). The VZ is an expanded space that results from merging the sub-viewing zones (SVZs) from which an individual view is made. To increase the viewing angle, many SVZs are usually required. In this paper, we propose a table -ornament electronic holographic display that utilizes 3f parabolic mirrors. In holography, the VZ is not simply expanded but synthesized from SVZs to implement continuous motion parallax. Our proposed system is small enough to be applied as a table ornament, in contrast to traditional tabletop displays that are large and not easily portable. By combining multiview and holographic technologies, our system achieves continuous motion parallax. Specifically, our system projects 340 views using a time -multi-plexing method over a range of 240 degrees. | Heo, Daerak; Jeon, Hosung; Lim, Sungjin; Hahn, Joonku | Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea | 57197871664; 56663784700; 56706721300; 10142501600 | jhahn@knu.ac.kr; | CURRENT OPTICS AND PHOTONICS | CURR OPT PHOTONICS | 2508-7266 | 2508-7274 | 7 | 2 | SCIE | OPTICS | 2023 | 0.6 | 91.2 | 0.32 | 2025-06-25 | 2 | 2 | Electronic holography; High-speed scanner; Tabletop displays; Three-dimensional display; Viewing zone | INTEGRAL-FLOATING DISPLAY; SYSTEM | Electronic holography; High-speed scanner; Tabletop displays; Three-dimensional display; Viewing zone | Field emission displays; Geometrical optics; Holographic displays; Continous motion; Electronic holography; High Speed; High-speed scanner; Motion parallax; Tabletop displays; Three dimensional (3D) display; Three-dimensional display; Viewing zone; Wide field-ofview; Three dimensional displays | English | 2023 | 2023-04 | 10.3807/copp.2023.7.2.183 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Continuous-phase Lens Design via Binary Dielectric Annular Nanoslits | In this study, a binary dielectric annular nanoring lens is proposed to cover the full range of optical phase. The lens is designed numerically, based on the effective-medium theory. The performance of the proposed lens is verified for the cases of single-focal and dual-focal lenses. The efficiency of a single focal lens is improved by 17.19% compared to a binary dielectric lens, and that of a dual-focal lens shows enhancements of 13.11% and 49.41% at the two focal points. This lens design can be applied to other optical components with axially symmetric structures. | Na, Woongbu; Lee, Seung-Yeol; Kim, Hyuntai | Hongik Univ, Elect & Elect Convergence Dept, Sejong 30016, South Korea; Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea | 58410206300; 55881869300; 57218447829 | hyuntai@hongik.ac.kr; | CURRENT OPTICS AND PHOTONICS | CURR OPT PHOTONICS | 2508-7266 | 2508-7274 | 7 | 3 | SCIE | OPTICS | 2023 | 0.6 | 91.2 | 0 | 2025-06-25 | 0 | 0 | Effective medium theory; Lens system design; Nanostructures; Subwavelength structures | POLARIZATION | Effective medium theory; Lens system design; Nanostructures; Subwavelength structures | Nanostructured materials; Nanostructures; Seismic waves; Continuous phase; Dielectric lens; Effective media theory; Focal lens; Lens designs; Lens system designs; Nanoslits; Optical phasis; Performance; Sub-wavelength structures; Lenses | English | 2023 | 2023-06 | 10.3807/copp.2023.7.3.304 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Dual Fabry-Perot Interferometer to Improve the Color Purity of Displays | We propose a dual Fabry-Perot interferometer (DFPI) structure that combines two Fabry-Perot interferometers. The structure is designed to have spectral peaks in the red, green, and blue regions si-multaneously, to be applicable to R, G, and B subpixels without any patterning process. The optimized structure has been fabricated on a glass substrate using a thermal evaporation technique. When the DFPI structure was attached to the quantum-dot color-conversion layer, the full width at half maximum values of the green and red spectra decreased by 47.29% and 51.07% respectively. According to CIE 1931 col-or space, the DFPI showed a 37.66% wider color gamut than the standard RGB color coordinate. Thus it was experimentally proven that the proposed DFPI structure improved color purity. This DFPI structure will be useful in realizing a display with high color purity. | Shin, Keun Soo; Kim, Jun Yong; Do, Yun Seon | Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea | Kim, Jung Kyu/C-3271-2012 | 58245349500; 57209837877; 24338060500 | yuns.do@knu.ac.kr; | CURRENT OPTICS AND PHOTONICS | CURR OPT PHOTONICS | 2508-7266 | 2508-7274 | 7 | 2 | SCIE | OPTICS | 2023 | 0.6 | 91.2 | 0 | 2025-06-25 | 0 | 0 | Color gamut; Color purity; Fabry-Perot; Full width half maximum; Quantum dot | LIGHT-EMITTING-DIODES; OPTICAL-PROPERTIES; LARGE-AREA; QUANTUM; SPECTROSCOPY; EFFICIENT | Color gamut; Color purity; Fabry-Perot; Full width half maximum; Quantum dot | Color; Glass substrates; Nanocrystals; Semiconductor quantum dots; Thermal evaporation; Color gamuts; Color purity; Fabry-Perot; Full width half maximum; Glass substrates; Optimized structures; Patterning process; Quantum dot; Spectral peak; Sub-pixels; Fabry-Perot interferometers | English | 2023 | 2023-04 | 10.3807/copp.2023.7.2.191 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Volumetric 3D Display: Features and Classification | Volumetric 3D displays generate voxels to enable users to watch three-dimensional virtual objects from various angles, and they have a significant advantage over other types of 3D displays in terms of realism and the absence of vergence-accommodation conflict (VAC). By virtue of these advantages, various volumetric 3D display technologies incorporating novel approaches have been introduced competitively. As a result, the conventional classification criteria for volumetric 3D technology often fall short in categorizing these innovative methods. In this study, we present an improved classification framework capable of accommodating these new technologies. We expect that a new classification may offer some intuition to identify areas of technical deficiency and contribute to improving the technology. | Hahn, Joonku; Moon, Woonchan; Jeon, Hosung; Jung, Minwoo; Lee, Seongju; Lee, Gunhee; Choi, Muhan | Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea | 10142501600; 56340460500; 56663784700; 57216159562; 58636781900; 57687190900; 7402093793 | mhchoi@ee.knu.ac.kr; | CURRENT OPTICS AND PHOTONICS | CURR OPT PHOTONICS | 2508-7266 | 2508-7274 | 7 | 6 | SCIE | OPTICS | 2023 | 0.6 | 91.2 | 0.21 | 2025-06-25 | 3 | 4 | Three-dimensional display; View volume; Viewpoints; Volumetric display; Voxel | Three-dimensional display; View volume; Viewpoints; Volumetric display; Voxel | Photonics; 3-D displays; 3D-displays; Three-dimensional display; Vergences; View volume; Viewpoint; Virtual objects; Volumetric 3-D displays; Volumetric display; Voxel; Three dimensional displays | English | 2023 | 2023-12 | 10.3807/copp.2023.7.6.597 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | COMPARISON OF CONVOLUTIONAL NEURAL NETWORK IMAGE CLASSIFICATION PERFORMANCE RELATIVE TO THE AMOUNT OF TRAINING DATA USING CARDIOMEGALY X-RAY IMAGES | Deep learning simultaneously learns a large amount of data, correct answers (labels), and extracts and learns features from the data. When training a deep learning model, the amount of data in your dataset has a significant impact on model performance. However, in the case of medical images, it is difficult to collect a large amount of data due to problems such as personal information protection. Also, since dedicated expertise is required to build an effective dataset, the amount of data that can be obtained is limited. Data augmentation techniques have been utilized to improve performance in various medical artificial intelligence studies and are considered an essential process to improve the performance of deep learning models. Data augmentation allows you to learn from different types of data. However, the standard process for achieving good performance when using a specific size of training data is still unclear. We compared the classification performance of several convolutional neural network models using datasets with different amounts of data to identify the optimal amount of training data that ensures good performance. We attempted to quantify the optimal amount of data for each convolutional neural network model by comparing overall results using both real and augmented datasets. | Kim, Minjeong; Kim, Junghun; Lee, Jongmin | Kyungpook Natl Univ, Dept Biomed Engn, Daegu 41566, South Korea; Kyungpook Natl Univ Hosp, Biomed Res Inst, Daegu 41940, South Korea; Kyungpook Natl Univ, Sch Med, Dept Radiol, Daegu 41944, South Korea | ; Lee, Jongmin/AAR-6361-2020 | 57911921300; 58567949800; 55689919700 | kmj5832@naver.com;fainal2@naver.com;jonglee@knu.ac.kr; | JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY | J MECH MED BIOL | 0219-5194 | 1793-6810 | 23 | 8 | SCIE | BIOPHYSICS;ENGINEERING, BIOMEDICAL | 2023 | 0.8 | 91.5 | 0.13 | 2025-06-25 | 0 | 1 | Chest X-ray; cardiomegaly; artificial intelligence; deep learning; convolutional neural network | artificial intelligence; cardiomegaly; Chest X-ray; convolutional neural network; deep learning | Classification (of information); Convolution; Deep learning; Image classification; Learning systems; Medical imaging; Neural network models; Cardiomegaly; Chest X-ray; Classification performance; Convolutional neural network; Deep learning; Large amounts of data; Learn+; Learning models; Performance; Training data; Convolutional neural networks | English | 2023 | 2023-10 | 10.1142/s021951942340081x | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | IMPORTANCE OF BODY BALANCE DURING SLEEP: COMPARISON OF FLAT AND TRANSFORMING BEDS | Body imbalance is one cause of sleep disorders. If one continues to sleep in an unbalanced state, various diseases, as well as headaches and stress, may occur. Some studies have been conducted to solve body imbalance during sleep, but most have used spring mattresses, and because body pressure varies by user, limitations exist for balancing pressure with this type of mattress. In our study, we investigated sleep quality using a transforming bed that conformed to the body and a flat bed that did not conform, considering user body pressure on both. We evaluated sleep quality with polysomnography and the Pittsburgh Sleep Quality Index, Korean version (PSQI-K) for 30 participants. Polysomnography showed that the ratio of delta and alpha waves in flat bed sleep was high; the ratio of theta waves was higher in transforming bed sleep than it was in flat bed sleep. The PSQI-K showed that most participants had a lower sleep index when using the transforming bed than when using the flat bed. Thus, we confirmed that sleep quality using a transforming bed was better than that of a flat bed. Therefore, considering body balance during sleep can help improve sleep quality. | Choi, Jeongrim; Park, Jieun; Kim, Junghun; Lee, Jongmin | Kyungpook Natl Univ, Dept Biomed Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, Nonlinear Dynam Res Ctr, Daegu 41544, South Korea; Kyungpook Natl Univ Hosp, Biomed Res Inst, Daegu 41940, South Korea; Kyungpook Natl Univ & Hosp, Sch Med, Dept Radiol, Daegu 41944, South Korea | Lee, Jongmin/AAR-6361-2020 | 58684978400; 57209642201; 58567949800; 55689919700 | fainal2@naver.com;jonglee@knu.ac.kr; | JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY | J MECH MED BIOL | 0219-5194 | 1793-6810 | 23 | 08 | SCIE | BIOPHYSICS;ENGINEERING, BIOMEDICAL | 2023 | 0.8 | 91.5 | 0 | 2025-06-25 | 1 | 0 | Body imbalance; Flat bed; Transforming bed; Polysomnography; PSQI-K | RISK | Body imbalance; Flat bed; Polysomnography; PSQI-K; Transforming bed | Body imbalance; Body pressure; Flat beds; Pittsburgh; Pittsburgh sleep quality index, korean version; Polysomnography; Quality indices; Sleep disorders; Sleep quality; Transforming bed; Sleep research | English | 2023 | 2023-10 | 10.1142/s0219519423400602 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Diagnostic Performance of Interferon Gamma Release Assay (IGRA) for Cell-Mediated Immune Responses to SARS-CoV-2 | Background: As SARS-CoV-2 infection became a pandemic, much effort has been made to measure both antibody production and T cell response to SARS-CoV-2 to diagnose COVID-19 patients or find out their immune status. Authors tried to determine the optimal cutoff value and evaluate clinical performance of one interferon-gamma release assay (IGRA) kit and compared their results with serological antibody assay in COVID-19 patients.Methods: Study subjects included 100 patients confirmed as COVID-19 with RT-PCR method and 88 healthy vol-unteers who were PCR negative. IGRA tests were performed using STANDARDTM E Covi-FERON ELISA. Pres-ence of SARS-CoV-2 antibodies was detected using STANDARD Q COVID-19 IgM/IgG Plus Test. Cutoff value was assessed using receiver operating characteristic (ROC) curve.Results: The cutoff value was 0.24 IU/mL and the area under the curve (AUC) of the ROC curve was 0.973 with 95% confidence interval (CI) of 0.940 -1.005. At this cutoff value, sensitivity and specificity were 91.7% and 100%, respectively. In addition, when compared with antibody test, concordance rate was 95%.Conclusions: STANDARDTM E Covi-FERON ELISA showed high sensitivity and specificity, when the cutoff value was 0.24 IU/mL. It was also consistent with the antibody test. IGRA test was a good indicator of cellular immune response in COVID-19 patients.(Clin. Lab. 2023;69:xx-xx. DOI: 10.7754/Clin.Lab.2022.220643) | Ham, Ji Yeon; Lee, Nan Young; Hwang, Narae; Song, Kyung Eun | Kyungpook Natl Univ, Chilgok Hosp, Dept Lab Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Clin Pathol, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Lab Med, 807 Hoguk Ro, Daegu 41404, South Korea | lee, nan/HZM-0321-2023 | 56464754800; 57209204358; 57224639090; 57843936100 | kesong@knu.ac.kr; | CLINICAL LABORATORY | CLIN LAB | 1433-6510 | 69 | 3 | SCIE | MEDICAL LABORATORY TECHNOLOGY | 2023 | 0.7 | 91.9 | 0.42 | 2025-06-25 | 3 | 4 | SARS-CoV-2; T cell response; cutoff value; IGRA | cutoff value; IGRA; SARS-CoV-2; T cell response | Antibodies, Viral; COVID-19; COVID-19 Testing; Humans; Immunity, Cellular; Immunoglobulin G; Interferon-gamma Release Tests; SARS-CoV-2; Sensitivity and Specificity; immunoglobulin G; immunoglobulin M; immunoglobulin G; virus antibody; adult; area under the curve; Article; cellular immunity; comparative study; controlled study; coronavirus disease 2019; diagnostic value; enzyme linked immunosorbent assay; human; immunoassay; interferon gamma release assay; major clinical study; real time polymerase chain reaction; receiver operating characteristic; sensitivity and specificity; Severe acute respiratory syndrome coronavirus 2; cellular immunity; diagnosis; interferon gamma release assay | English | 2023 | 2023 | 10.7754/clin.lab.2022.220643 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Evaluation of Investment Strategies for Automated Material Handling Systems in Semiconductor/Display Fabrication | In the semiconductor and display industries, the automated material handling system (AMHS) represents an important component of fabrication facilities, which typically cost more than multi-billions of US dollars to build. One unit of fabrication facility consists of hundreds of processing steps with hundreds of expensive toolsets, and a production unit is completed after traveling over 9km for more than a month in the facility. Since all material handlings within the fabrication facility are performed by AMHS with minimal human intervention, the proper capacity of AMHS plays a very important role in fabrication operation. If the capacity is too large, it wastes the capacity of the production process as it potentially occupies too much space and investment. On the other hand, if the capacity of AMHS is too small, products under processing cannot be delivered to the expensive process toolsets on time, which causes a drop in productivity. This paper proposes an analytical method for assessing capacity planning strategies for the AMHS under various ramp-up scenarios. It proposes an analytical model consisting of three cost elements including fixed, operating, and delay costs measured by Erlang's loss system to evaluate various investment alternatives based on the cost-of-ownership approach. We carefully prepared input data based on expert opinions to conduct an experiment that considers investment estimates for the three hypothetical alternatives. The experimental results illustrate that one-step strategy or lead strategy should be used depending on the fabrication facility's ramp-up speed, which can be analyzed by the model proposed by this paper. | Son, Seolhui; Chung, Jaewoo | Kyungpook Natl Univ, Sch Business Adm, Daegu Main Campus,80 Daehak Ro, Daegu, South Korea | 56527720900; 55470448800 | ttgtwd@gmail.com;chung@knu.ac.kr; | JOURNAL OF ADVANCED MANUFACTURING SYSTEMS | J ADV MANUF SYST | 0219-6867 | 1793-6896 | 22 | 04 | ESCI | ENGINEERING, MANUFACTURING | 2023 | 0.9 | 91.9 | 0 | 2025-06-25 | 0 | 0 | Capacity planning; material handling; production economics; automated manufacturing systems; smart manufacturing; semiconductor/display manufacturing | AMHS PERFORMANCE; LAYOUT; DESIGN | automated manufacturing systems; Capacity planning; material handling; production economics; semiconductor/display manufacturing; smart manufacturing | Automation; Costs; Economics; Investments; Materials handling; Materials handling equipment; Automated manufacturing systems; Automated material handling systems; Capacity planning; Investment strategy; Material handling; Production economics; Ramp up; Semiconductor/display manufacturing; Smart manufacturing; Toolsets; Fabrication | English | 2023 | 2023-12 | 10.1142/s0219686723500439 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Evaluation of two SARS-CoV-2 IgG/IgM Rapid Tests in Capillary Blood Samples | Background: As COVID-19 has spread rapidly around the world, it has become essential to detect the virus quick-ly and accurately for disease prevention and control. Therefore, in response to the COVID-19 pandemic, the need for rapid serological point-of-care test has increased. Recently, many antibody tests have been developed to detect IgM and/or IgG to SARS-CoV-2 in human blood. The authors conducted a prospective study to evaluate the per-formance of a rapid chromatographic immunoassay and a fluorescent immunoassay for the qualitative detection of specific antibodies, IgM and IgG to SARS-CoV-2 in capillary blood samples, compared to the real-time RT-PCR.Methods: The subjects included 70 patients who were confirmed positive by real-time RT-PCR and 70 people who were negative. STANDARD Q COVID-19 IgM/IgG Plus Test (chromatographic immunoassay) and Fluorescent immunoassay for IgM and IgG to SARS-CoV-2 (fluorescent immunoassay) were performed using capillary blood samples. Based on the results of real-time RT-PCR assay, clinical sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of two rapid tests were investigated. And the agreement rate between two rapid tests was also presented.Results: Sensitivity, specificity, PPV and NPV of the chromatographic immunoassay were 82.9%, 98.6%, 98.3%, and 85.2%, respectively. At more than 7 days after the onset of symptoms, sensitivity increased to 87.3%. Sensitiv-ity, specificity, PPV, and NPV were 81.4%, 100.0%, 100.0%, and 84.3%, respectively, for the fluorescent immu-noassay. At more than 7 days after the onset of symptoms, sensitivity increased to 85.7%. The agreement rate of the two tests was 97.1%. Conclusions: STANDARD Q COVID-19 IgM/IgG Plus Test and STANDARD F COVID-19 IgM/IgG Combo FIA turned out very specific and sensitive enough to detect individuals infected to SARS-CoV-2. Also, these tests were simple, fast, visually interpretable, and required a small amount of capillary whole blood.(Clin. Lab. 2023;69:xx-xx. DOI: 10.7754/Clin.Lab.2022.220421) | Lee, Nan Young; Ham, Ji Yeon; Hwang, Narae; Song, Kyung Eun | Kyungpook Natl Univ, Chilgok Hosp, Dept Lab Med, 807 Hoguk Ro, Daegu 41404, South Korea; Kyungpook Natl Univ, Sch Med, Dept Clin Pathol, Daegu, South Korea | lee, nan/HZM-0321-2023 | 57209204358; 56464754800; 57224639090; 57843936100 | kesong@knu.ac.kr; | CLINICAL LABORATORY | CLIN LAB | 1433-6510 | 69 | 1 | SCIE | MEDICAL LABORATORY TECHNOLOGY | 2023 | 0.7 | 91.9 | 0.21 | 2025-06-25 | 2 | 2 | COVID-19 pandemic; point-of-care test; IgM and; or IgG to SARS-CoV-2; capillary whole blood | ANTIBODY-RESPONSES | capillary whole blood; COVID-19 pandemic; IgM and/or IgG to SARS-CoV-2; point-of-care test | Antibodies, Viral; COVID-19; COVID-19 Testing; Humans; Immunoassay; Immunoglobulin G; Immunoglobulin M; Pandemics; Prospective Studies; SARS-CoV-2; Sensitivity and Specificity; immunoglobulin G; immunoglobulin M; immunoglobulin G; immunoglobulin M; virus antibody; adult; antibody production; Article; blood sampling; capillary blood; controlled study; coronavirus disease 2019; COVID-19 nucleic acid testing; diagnostic test accuracy study; evaluation study; human; immunofluorescence assay; intermethod comparison; major clinical study; predictive value; prospective study; qualitative analysis; real time reverse transcription polymerase chain reaction; sensitivity and specificity; Severe acute respiratory syndrome coronavirus 2; task performance; diagnosis; immunoassay; pandemic; procedures | English | 2023 | 2023 | 10.7754/clin.lab.2022.220421 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | First Case of Pseudoclavibacter alba Bacteremia in a Patient with Cholangitis | Background: Pseudoclavibacter alba isolated from human urine in culture collection was introduced as a new species, but since then, no other reports on P. alba isolated from the environment or organisms have been published. We thus present the first case report of P. alba bacteremia.Methods: An 85-year-old female patient was admitted with intermittent abdominal pain and chills that had persisted for one week. She was diagnosed cholangitis with common bile duct stones.Results: Gram-positive bacteria were detected in her peripheral blood culture and identified Pseudoclavibacter species by matrix-assisted laser desorption-ionization-time of flight mass spectrometry. Pseudoclavibacter alba was identified by performing the 16S ribosomal RNA gene sequence.Conclusions: This is the first case report of P. alba bacteremia in a patient with cholangitis. | Kim, Yu Kyung; Yu, Won Seon; Kim, Suyeon; Ryoo, Nam Hee; Lee, Je Chul; Kwon, Ki Tae; Lee, Nan Young; Lee, Da Eun; Hwang, Hye Ryung | Kyungpook Natl Univ, Sch Med, Dept Clin Pathol, Daegu, South Korea; Kyungpook Natl Univ Hosp, Culture Collect Pathogens Bank, Daegu, South Korea; Natl Inst Hlth, Div Pathogen Resource Management, Cheongju, South Korea; Keimyung Univ, Dept Lab Med, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Microbiol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ Hosp, Dept Lab Med, 130 Dongdeok Ro, Daegu 41944, South Korea | Kim, Hanjin/KYP-2633-2024 | 9237571900; 58368167300; 58368841200; 7801573357; 25930392000; 9733850500; 57209204358; 57224099074; 58370237500 | kimukn@hanmail.net; | CLINICAL LABORATORY | CLIN LAB | 1433-6510 | 69 | 6 | SCIE | MEDICAL LABORATORY TECHNOLOGY | 2023 | 0.7 | 91.9 | 0 | 2025-06-25 | 0 | 0 | Pseudoclavibacter alba; cholangitis; blood culture; bac-teremia | Bac-Teremia; Blood culture; Cholangitis; Pseudoclavibacter alba | Abdominal Pain; Actinobacteria; Aged, 80 and over; Bacteremia; Cholangitis; Female; Humans; Pseudoclavibacter alba; amikacin; bacterial RNA; ceftriaxone; ciprofloxacin; clindamycin; flomoxef; RNA 16S; vancomycin; abdominal pain; aged; antibiotic sensitivity; antibiotic therapy; Article; bacteremia; blood culture; case report; chill; cholangitis; cholecystectomy; cholecystitis; cholelithiasis; clinical article; common bile duct stone; computer assisted tomography; disk diffusion; endoscopic retrograde cholangiopancreatography; female; fever; gene sequence; Gram positive bacterium; hospital admission; human; matrix assisted laser desorption ionization time of flight mass spectrometry; Pseudoclavibacter alba; very elderly; Actinobacteria; bacteremia; cholangitis | English | 2023 | 2023 | 10.7754/clin.lab.2022.221004 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Incidence and Distribution of the Pathogens Causing GI Infections at a University Hospital of Korea | Background: Gastrointestinal (GI) infections, caused by various pathogens such as bacteria, viruses, protozoa, and parasites, are the second most common infectious diseases. Molecular diagnostics that can simultaneously detect these pathogens are commonly used in syndromic approaches. The authors aimed to identify the causative pathogens of GI infections to provide clinically useful information.Methods: This retrospective study used molecular diagnostic methods to determine the incidence and distribution of GI pathogens according to gender, age, and season and analyze their co-infection from August 2020 to December 2022.Results: The overall incidence of at least one GI pathogen was 40.1% (991/2, 471). The positivity rates for bacteria and viruses were 33.1% (817/2, 471) and 9.2% (227/2,471), respectively; the positivity rate for bacteria was signifiantly higher than that for viruses (p < 0.001). The incidence of GI pathogens according to age group was highest in group 3 (59.9%), followed by group 4 (57.0%). The most common bacterial pathogen associated with GI infections was C. difficile, followed by diarrheagenic E. coli, Campylobacter spp., and Salmonella spp. Enteropathogenic E. coli accounted for a large percentage of diarrheagenic E. coli (63.6%, 157/247). Among the viral pathogens, norovirus GI/GII was the most commonly detected virus, followed by adenovirus F40/41 and rotavirus A. For bacterial-or viral-positive cases, the distribution of GI pathogens according to age group showed the highest proportion of C. difficile in all groups, except for group 2. In group 2, rotavirus A accounted for the highest percentage (61.1%, 22/36). The incidence of GI pathogens was the highest in summer (36.1%), followed by autumn (32.7%), and winter (18.0%). The co-infection rate with two or more pathogens was 16.9% (167/991). The rates of co-infection with two or more bacteria, bacteria and viruses, and two viruses were 58.1%, 31.7%, and 10.2%, respectively.Conclusions: Information on the incidence and distribution of GI pathogens might be clinically useful; however, unlike the distribution of other infectious pathogens, it is necessary to consider that microorganisms identified through molecular diagnostics can be detected even in healthy people without clinical symptoms. | Ham, Ji Yeon; Song, Kyung Eun; Oh, Hee Jeong; Kim, Il Duk; Kim, Dae Won; Mok, Ju Hyun; Jung, Seung Jin; Kwon, Ki Tae; Lee, Nan Young | Kyungpook Natl Univ, Chilgok Hosp, Dept Lab Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Clin Pathol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Div Infect Dis, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Dept Lab Med, Chilgok Hosp, 807 Hoguk Ro, Daegu 41404, South Korea | ; Kim, Hanjin/KYP-2633-2024 | 56464754800; 57843936100; 58574848800; 58574848900; 58574836300; 58574829200; 58574842700; 9733850500; 57209204358 | leenanyoung70@gmail.com; | CLINICAL LABORATORY | CLIN LAB | 1433-6510 | 69 | 9 | SCIE | MEDICAL LABORATORY TECHNOLOGY | 2023 | 0.7 | 91.9 | 0 | 2025-06-25 | 0 | 0 | GI infections; pathogens; incidence and distribution; C. difficile; co-infection | ACUTE GASTROENTERITIS; DIAGNOSIS; MULTICENTER; EPIDEMIOLOGY; COINFECTION; CHILDREN; VIRUSES; PANEL | C. difficile; co-infection; GI infections; incidence and distribution; pathogens | Clostridioides difficile; Coinfection; Communicable Diseases; Escherichia coli; Gastrointestinal Diseases; Hospitals, University; Humans; Incidence; Norovirus; Republic of Korea; Retrospective Studies; Rotavirus; Adenoviridae; adolescent; adult; age distribution; Article; autumn; Campylobacter; child; Clostridioides difficile; coinfection; controlled study; data analysis; diarrheagenic Escherichia coli; enteropathogenic Escherichia coli; female; gastrointestinal infection; human; incidence; infant; infectious agent distribution; information; Korea; major clinical study; male; molecular diagnosis; newborn; nonhuman; Norovirus; positivity rate; retrospective study; Rotavirus A; Salmonella; summer; university hospital; winter; Clostridioides difficile; coinfection; communicable disease; Escherichia coli; gastrointestinal disease; incidence; Norovirus; Rotavirus; South Korea; university hospital | English | 2023 | 2023 | 10.7754/clin.lab.2023.230404 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Recent Changes in the Human Metapneumovirus Outbreak at a University Hospital in Korea | Background: Although the detection of respiratory viruses other than severe acute respiratory syndrome corona -virus 2 (SARS-CoV-2) was significantly reduced because of quarantine due to the coronavirus disease (COVID-19) pandemic, an epidemic of several viruses was reported unexpectedly. We also detected a change in the pattern of human metapneumovirus (HMPV) outbreak compared to that before the COVID-19 pandemic. Therefore, the authors intended to identify the incidence and altered distribution pattern of the HMPV outbreak and provide useful information for clinical practice.Methods: This retrospective study investigated the incidence and distribution of HMPV from March 2020 to December 2022 during the COVID-19 pandemic. Detection of respiratory microorganisms was performed by multi-plex polymerase chain reaction using a commercial kit and FilmArray assay.Results: The overall incidence of at least one respiratory microorganism was 50.3% (1,152/2,290). HMPV was not detected between March 2020 and June 2022. However, it was suddenly detected in July 2022 and continued for approximately five months until November 2022. In particular, the detection rate of HMPV was high in September and October 2022, accounting for approximately 76.1% (51/67) of the total HMPV-positive cases. Seasonally, 92.5% (62/67) of HMPV cases were detected in autumn, while the rest of the cases were detected in summer. The HMPV detection rate, according to the age group, was highest in group 4 (3 -6 years) at 7.4% (27/367), followed by group 3 (4 months to 2 years) at 3.6% (31/861). In HMPV-positive cases, the rate of more than two respiratory pathogens was 46.3% (31/67). An analysis of co-infecting pathogens showed that HMPV with rhinovirus A/B/C/ enteroviruses accounted for the highest percentage (51.6%), followed by HMPV with respiratory syncytial virus (48.4%).Conclusions: The COVID-19 pandemic has caused several changes in our lives. This study confirmed that the sea-sonal distribution of HMPV was different from that before the COVID-19 pandemic. Therefore, it can be as-sumed that the distribution of other respiratory microorganisms could have changed and it appears that changes could occur in previously known viral epidemiology. Clinicians should therefore be alert to this possibility. (Clin. Lab. 2023;69:1708-1714. DOI: 10.7754/Clin.Lab.2023.230216) | Nam, Eon Jeong; Kim, Dong Ja; Ham, Ji Yeon; Song, Kyung Eun; Lee, Nan Young | Kyungpook Natl Univ, Sch Med, Dept Internal Med, Div Rheumatol, Daegu 41404, South Korea; Kyungpook Natl Univ, Sch Med, Dept Forens Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Clin Pathol, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Lab Med, Daegu, South Korea; Kyungpook Natl Univ, Dept Lab Med, Chilgok Hosp, 807 Hoguk Ro, Daegu 41404, South Korea | 7005824293; 57282881600; 56464754800; 57843936100; 57209204358 | leenanyoung70@gmail.com; | CLINICAL LABORATORY | CLIN LAB | 1433-6510 | 69 | 8 | SCIE | MEDICAL LABORATORY TECHNOLOGY | 2023 | 0.7 | 91.9 | 0.1 | 2025-06-25 | 0 | 1 | COVID-19 pandemic; human metapneumovirus; altered distribution | RESPIRATORY SYNCYTIAL VIRUS; PARAINFLUENZA VIRUS; INFECTIONS; INFLUENZA; EPIDEMIOLOGY; PATTERNS; CHILDREN; IMPACT; TIME | Child; Child, Preschool; COVID-19; Disease Outbreaks; Hospitals, University; Humans; Infant; Metapneumovirus; Pandemics; Paramyxoviridae Infections; Republic of Korea; Respiratory Syncytial Virus, Human; Respiratory Tract Infections; Retrospective Studies; SARS-CoV-2; Viruses; adolescent; adult; Article; child; coinfection; epidemic; female; human; Human metapneumovirus; Human metapneumovirus infection; Human respiratory syncytial virus; Human rhinovirus A; Human rhinovirus B; infant; Korea; major clinical study; male; multiplex polymerase chain reaction; nonhuman; retrospective study; seasonal variation; university hospital; coronavirus disease 2019; epidemic; genetics; Human respiratory syncytial virus; Metapneumovirus; pandemic; paramyxovirus infection; preschool child; respiratory tract infection; Severe acute respiratory syndrome coronavirus 2; South Korea; university hospital; virus | English | 2023 | 2023 | 10.7754/clin.lab.2023.230216 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | The Diagnostic Yield and Difficulties of Utilizing Soft-clipped Read Clusters Encountered in Clinical Exome Sequencing | Background: Despite the wide use of next generation sequencing, there are still many difficulties in detecting structural variants. A split read is one of the clues of structural variants and is represented as a soft-clipped read in the raw sequencing data. Considering that most of the breakpoints of structural variants reside in non-coding regions, split read information has not been routinely used in exome sequencing or targeted panel sequencing. Recently, SCRAMble, a software capable of detecting mobile element insertion (MEI) and deletion based on soft -clipped read clusters (SCRCs), was shown to provide an additional diagnostic yield of 0.03 -0.25%. SCRAMble is the only software that can be used for exome sequencing or targeted panel sequencing to detect structural variants based on SCRC information. The aim of present study was to establish a working procedure of utilizing SCRC in-formation using SCRAMble in clinical exome sequencing and to assess its diagnostic yield. Methods: Raw sequencing data of clinical exome sequencing were retrospectively analyzed using SCRAMble to search MEIs and deletions. SCRAMble software was installed according to the manufacturer's instructions and default parameters except for one, mei-score, which was adjusted for sensitivity, were used. RefSeq gene annota-tion was performed for both MEI and deletion calls using ANNOVAR. Blacklist-based filtering was used to re-duce candidate MEI/deletion calls. Clinical relevance was manually evaluated for the remaining variant calls. Results: One diagnostic MEI, which is a founder variant in East Asia, was detected in two cases (2/266, 0.75%). In addition, two diagnostic deletions, which had been previously detected in depth-of-coverage (DOC)-based copy number variant (CNV) callers, were detected (2/266, 0.75%). Base-level breakpoints that could not be derived by the DOC-based callers were identified for these two deletions using SCRAMble. Most SCRCs were repetitive among cases and blacklist-based filtering reduced candidate MEI/deletion calls by 49.5 -94.5%, leaving a consid-erable number of variant calls to be manually validated. Conclusions: SCRC screening in exome or targeted panel sequencing may provide additional diagnostic yield either by pathogenic MEI detection or reassurance of deletions identified by DOC-based CNV callers. Develop-ment of an efficient filtering algorithm is warranted. (Clin. Lab. 2023;69:771-780. DOI: 10.7754/Clin.Lab.2022.220731) | Kim, Young-gon; Lee, Nan Young; Ham, Ji Yeon; Lee, Taeheon; Ki, Chang-Seok; Song, Kyung Eun | Kyungpook Natl Univ, Sch Med, Dept Clin Pathol, Daegu, South Korea; Samsung Med Ctr, Dept Lab Med & Genet, Seoul, South Korea; Kyungpook Natl Univ, Dept Lab Med, Chilgok Hosp, 807 Hoguk Ro, Daegu 41404, South Korea; GC Genome, Yongin, South Korea | Ki, Chang-Seok/G-7559-2014 | 57221144632; 57209204358; 56464754800; 36552806100; 56800160200; 57843936100 | kesong@knu.ac.kr; | CLINICAL LABORATORY | CLIN LAB | 1433-6510 | 69 | 4 | SCIE | MEDICAL LABORATORY TECHNOLOGY | 2023 | 0.7 | 91.9 | 0 | 2025-06-25 | 0 | 0 | soft-clipped read clusters; mobile element insertion; SCRAMble; clinical exome sequencing | INSERTION CAUSES; ROTOR SYNDROME; IDENTIFICATION; FUKUTIN; VARIANT | clinical exome sequencing; mobile element insertion; SCRAMble; soft-clipped read clusters | Exome; Exome Sequencing; High-Throughput Nucleotide Sequencing; Humans; Retrospective Studies; Software; solute carrier organic anion transporter 1B3; spacer DNA; Article; Asia; copy number variation; depth of coverage; diagnostic value; DNA sequence; exon; familial hypercholesterolemia; gene deletion; gene frequency; gene insertion; genetic algorithm; genetic disorder; genetic parameters; genetic screening; genetic variability; human; intron; major clinical study; Markov chain; mobile element insertion; retrospective study; Rett syndrome; Rotor syndrome; sensitivity and specificity; sequence analysis; soft clipped read cluster; transposon; whole exome sequencing; exome; high throughput sequencing; procedures; software; whole exome sequencing | English | 2023 | 2023 | 10.7754/clin.lab.2022.220731 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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