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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Prediction of Liquefied Soil Settlement Using Multilayer Perceptron with Bayesian Optimization | Liquefaction-induced settlement in saturated loose soils is a commonly geotechnical phenomenon resulted from the loss of its shear strength under moderate or high seismicity. This can have detrimental effects on building, infrastructure, and even human life. Therefore, predicting the settlement of ground caused by liquefaction plays a critical role in the geotechnical field. As the limited data for liquefaction-induced settlement obtained, an effective method should be applied to provide highly accurate prediction. The aim of this study is to propose a machine learning approach, namely multilayer perceptron (MLP), with a wide range of hyperparameters optimized by the Bayesian optimization method to predict liquefaction-induced settlement due to the Pohang earthquake in South Korea. The ground settlement and its correlation with different soil conditions were taken into account including unit weight, soil layer depth, standard penetration test blow count, and cyclic stress ratio. Moreover, other five well-known models, namely linear regression, support vector machine, robust regression, and polynomial regression, were performed to facilitate a comparison study. The experimental result indicates that while the high influence of all considerable variables on the ground settlement was obtained from the correlation coefficients, the soil layer depth factor had the highest one. Based on the Bayesian optimization, a greater prediction accuracy was observed from the proposed MLP model compared to other methods by using the evaluation metric of R-squared value. Furthermore, the developed model outperforms other machine learning methods proposed by previous studies in terms of predicting the soil settlement caused by liquefaction. | Van Nguyen, Nhi; Van Le, Luong; Nguyen, Tan-No; Park, Sung-Sik; Tran, Thanh Danh | Ho Chi Minh City Open Univ, Fac Civil Engn, Ho Chi Minh City, Vietnam; Kyungpook Natl Univ, Dept Civil Engn, Daegu 41566, South Korea | ; TRAN, Thanh Danh/KVB-8255-2024 | 58906681700; 58905813800; 57862912800; 36241850300; 57226534956 | sungpark@knu.ac.kr;danh.tt@ou.edu.vn; | INDIAN GEOTECHNICAL JOURNAL | INDIAN GEOTECH J | 0971-9555 | 2277-3347 | 54 | 6 | ESCI | ENGINEERING, GEOLOGICAL | 2024 | 1.4 | 70.0 | 1.72 | 2025-05-07 | 3 | 4 | Liquefaction; Settlement; Machine learning; Multilayer perceptron; Bayesian optimization | Bayesian optimization; Liquefaction; Machine learning; Multilayer perceptron; Settlement | North Kyongsang; Pohang; South Korea; Geotechnical engineering; Learning systems; Multilayer neural networks; Multilayers; Regression analysis; Settlement of structures; Shear strength; Soil liquefaction; Soils; Support vector machines; Bayesian optimization; Geotechnical; Ground settlement; Liquefied soils; Loose soils; Machine-learning; Multilayers perceptrons; Settlement; Soil layer; Soil settlements; algorithm; Bayesian analysis; ground settlement; liquefaction; machine learning; optimization; prediction; Forecasting | English | 2024 | 2024-12 | 10.1007/s40098-024-00894-w | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Oxidation Study of Ni-W Alloy Matrix Coating Reinforced with Multiple Dissimilar Nanoparticles | A pulsed electrodeposition was performed on mild steel surfaces to prepare Ni-W-based composite coatings consisting of TiO2 and ZrO2 oxide nanoparticles. To evaluate the oxidative properties of coatings, isothermal oxidation studies were performed on the coatings at 873, 973, and 1073 K in the air for 30 h. The coatings' phase evolution, morphology, and chemistry were investigated by x-ray diffraction, field emission scanning electron microscopy, and energy-dispersive spectroscopy, respectively. As a result of examining the microstructure changes after the oxidation test, it was found that the oxide formation increased according to the oxidation temperature. To determine the oxidation kinetics of the respective coatings, Arrhenius plots were drawn and activation energies were calculated. The final results confirmed that the oxidation resistance of the Ni-W-TiO2-ZrO2 nanocomposite coatings (NiWNC) increased with the addition of ZrO2 (0 -15 g/L). In this study, better oxidation resistance was observed for the Ni-W-5 g/L TiO2-15 g/L ZrO2 nanocomposites compared to the rest of the coatings. These findings highlight the potential of producing highly oxidation-resistant coatings using a cost-effective method on commercially available metal surfaces such as mild steels. | Shaik, Shajahan; Kushwaha, Adarsh; Basu, Anindya | Kyungpook Natl Univ, Dept Chem & Green Nano Mat Res Ctr, Deahak Ro 80, Daegu 41566, South Korea; Natl Inst Technol Rourkela, Dept Met & Mat Engn, Rourkela 769008, India | Shaik, Shajahan/AAL-6905-2020; Kushwaha, Adarsh/GNH-2417-2022 | 57204456317; 57213156901; 55697226100 | shajahaniiit@gmail.com; | JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE | J MATER ENG PERFORM | 1059-9495 | 1544-1024 | 33 | 24 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY | 2024 | 2 | 70.3 | 0.62 | 2025-05-07 | 2 | 2 | activation energies; nanocomposite; Ni-W; oxidation kinetics; TiO2 and ZrO2 | TEMPERATURE; ANATASE; TIO2; COMPOSITES; BEHAVIOR; ZRO2 | activation energies; nanocomposite; Ni-W; oxidation kinetics; TiO<sub>2</sub> and ZrO<sub>2</sub> | Binary alloys; Cobalt alloys; Composite coatings; Cost effectiveness; Energy dispersive spectroscopy; Field emission microscopes; Low carbon steel; Metallic matrix composites; Morphology; Nanocomposites; Nickel alloys; Oxidation; Oxidation resistance; Scanning electron microscopy; TiO2 nanoparticles; Titanium alloys; Titanium dioxide; Zirconia; Composites coating; Matrix coating; Mild-steel surfaces; Ni-W; Oxidation kinetics; Oxidative properties; Oxide nanoparticles; Pulsed electrodeposition; Pulsed-electrodeposition; TiO 2 and ZrO 2; Activation energy | English | 2024 | 2024-12 | 10.1007/s11665-023-09002-0 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | AONet: Attention network with optional activation for unsupervised video anomaly detection | Anomaly detection in video surveillance is crucial but challenging due to the rarity of irregular events and ambiguity of defining anomalies. We propose a method called AONet that utilizes a spatiotemporal module to extract spatiotemporal features efficiently, as well as a residual autoencoder equipped with an attention network for effective future frame prediction in video anomaly detection. AONet utilizes a novel activation function called OptAF that combines the strengths of the ReLU, leaky ReLU, and sigmoid functions. Furthermore, the proposed method employs a combination of robust loss functions to address various aspects of prediction errors and enhance training effectiveness. The performance of the proposed method is evaluated on three widely used benchmark datasets. The results indicate that the proposed method outperforms existing state-of-the-art methods and demonstrates comparable performance, achieving area under the curve values of 97.0%, 86.9%, and 73.8% on the UCSD Ped2, CUHK Avenue, and ShanghaiTech Campus datasets, respectively. Additionally, the high speed of the proposed method enables its application to real-time tasks. | Rakhmonov, Akhrorjon Akhmadjon Ugli; Subramanian, Barathi; Varnousefaderani, Bahar Amirian; Kim, Jeonghong | Kyungpook Natl Univ, Dept Comp Sci & Engn, Daegu, South Korea | Subramanian, Barathi/HLP-9548-2023 | 58482208000; 57221053219; 59393624700; 55138548100 | jhk@knu.ac.kr; | ETRI JOURNAL | ETRI J | 1225-6463 | 2233-7326 | 46 | 5 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC;TELECOMMUNICATIONS | 2024 | 1.6 | 70.4 | 0.39 | 2025-05-07 | 0 | 1 | activation function; convolutional neural network; loss function; unsupervised learning; video anomaly detection | activation function; convolutional neural network; loss function; unsupervised learning; video anomaly detection | Anomaly detection; Unsupervised learning; Activation functions; Anomaly detection; Auto encoders; Convolutional neural network; Loss functions; Performance; Sigmoid function; Spatiotemporal feature; Video anomaly detection; Video surveillance; Convolutional neural networks | English | 2024 | 2024-10 | 10.4218/etrij.2024-0115 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Are Overconfidence and the Accurate Calibration of Performance Mutually Incompatible? | The present study investigated whether calibration accuracy in metacognitive judgment on performance and the positively biased self-evaluation of competence are distinct and whether they play independent roles in learning. A sample of 432 sixth-graders reported their pre-test competence for solving math problems and the post-test calibration of performance, and these measures were compared with their actual math-test scores to compute overconfidence and calibration accuracy. Data analyses indicated (a) that a positive correlation existed between accurate calibration and overconfidence; (b) that high-achieving students calibrated performance accurately but overestimated their competence; and (c) that accurate calibration and overconfidence independently predicted positive learning behaviors, highlighting that both self-evaluation indices contribute to self-regulated learning in their own way. | Lee, Eunju J. | Kyungpook Natl Univ, Daegu, South Korea | 55491752300 | elee@knu.ac.kr; | JAPANESE PSYCHOLOGICAL RESEARCH | JPN PSYCHOL RES | 0021-5368 | 1468-5884 | 66 | 3 | SSCI | PSYCHOLOGY, MULTIDISCIPLINARY | 2024 | 0.8 | 70.4 | 0 | 2025-05-07 | 0 | 0 | self-evaluation bias; self-estimation bias; overconfidence; calibration accuracy; self-regulated learning | ACHIEVEMENT EMOTIONS; SELF-ENHANCEMENT; STUDENTS; QUESTIONNAIRE; MOTIVATION; EFFICACY | calibration accuracy; overconfidence; self-estimation bias; self-evaluation bias; self-regulated learning | English | 2024 | 2024-07 | 10.1111/jpr.12409 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Effects of parasitic gate capacitance and gate resistance on radiofrequency performance in LG=0.15 μm GaN high-electron-mobility transistors for X-band applications | The effects of the parasitic gate capacitance and gate resistance (R-g) on the radiofrequency (RF) performance are investigated in L-G = 0.15 mu m GaN high-electron-mobility transistors with T-gate head size ranging from 0.83 to 1.08 mu m. When the device characteristics are compared, the difference in DC characteristics is negligible. The RF performance in terms of the current-gain cut-off frequency (f(T)) and maximum oscillation frequency (f(max)) substantially depend on the T-gate head size. For clarifying the T-gate head size dependence, small-signal modeling is conducted to extract the parasitic gate capacitance and R-g. When the T-gate head size is reduced from 1.08 to 0.83 mu m, R-g increases by 82%, while f(T) and f(max) improve by 27% and 26%, respectively, because the parasitic gate-source and gate-drain capacitances reduce by 19% and 43%, respectively. Therefore, minimizing the parasitic gate capacitance is more effective that reducing R-g in our transistor design and fabrication, leading to improved RF performance when reducing the T-gate head size. | Chang, Sung-Jae; Jeong, Hyeon-Seok; Jung, Hyun-Wook; Choi, Su-Min; Choi, Il-Gyu; Noh, Youn-Sub; Kim, Seong-Il; Lee, Sang-Heung; Ahn, Ho-Kyun; Kang, Dong Min; Kim, Dae-Hyun; Lim, Jong-Won | Elect & Telecommun Res Inst, Terr & Nonterr Integrated Telecommun Res Lab, Daejeon, South Korea; Kyungpook Natl Univ, Dept Elect & Elect Engn, Daejeon, South Korea | Jung, Hyun/F-6898-2013; Kim, Junghwan/AAQ-9204-2021 | 36699164100; 57200366272; 57192233439; 57825819100; 56424837700; 27967911900; 57900970600; 36063034000; 55704330000; 57213749090; 57212363794; 7403453759 | sjchang@etri.re.kr; | ETRI JOURNAL | ETRI J | 1225-6463 | 2233-7326 | 46 | 6 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC;TELECOMMUNICATIONS | 2024 | 1.6 | 70.4 | 0.77 | 2025-05-07 | 2 | 2 | GaN; gate head size; gate resistance; high-electron-mobility transistor; parasitic gate capacitance; small-signal modeling; T-gate | ALGAN/GAN HEMTS; T-GATE; CONTACTS; SILICON | GaN; gate head size; gate resistance; high-electron-mobility transistor; parasitic gate capacitance; small-signal modeling; T-gate | Capacitance; Electron mobility; High electron mobility transistors; III-V semiconductors; Gate capacitance; Gate head size; Gate resistance; Head size; High electron-mobility transistors; Parasitic gate capacitance; Parasitics; Radiofrequencies; Small signal model; T-gates; Gallium nitride | English | 2024 | 2024-12 | 10.4218/etrij.2023-0250 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Circulating-tumor DNA Assessment in Diffuse Large B-cell Lymphoma to Determine Up-front Stem Cell Transplantation: A Pilot Study | Background/Aim: This study evaluated the possibility of clinical use of circulating-tumor DNA (ctDNA) as a biomarker to determine up-front autologous stem cell transplantation (auto-SCT) for patients with high-risk diffuse large B-cell lymphoma (DLBCL) in practice. Patients and Methods: To explore the dynamics of ctDNA in DLBCL, blood samples were collected sequentially before and after treatment from patients with newly diagnosed DLBCL who received rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) chemotherapy. To conduct ctDNA genotyping and ctDNA monitoring simultaneously, targeted sequencing by cancer personalized profiling using deep sequencing was used. Results: Ten patients between the ages of 50 and 60 years were enrolled. Based on the international prognostic index (IPI), seven patients were classified as highIPI-risk group, and three patients were classified as low-IPIrisk group. The IPI risk group correlated with total metabolic tumor volume. All patients completed six cycles of R-CHOP chemotherapy, and seven patients achieved complete response. Changes in ctDNA mutation numbers did not correlate with changes in PET scan images and treatment response. In most high-risk patients, new mutations appeared in ctDNA after completion of chemotherapy that conceivably marked resistant clones. Notably, disease relapse did not occur in high-risk patients with poor prognostic mutations who underwent autologous SCT. Conclusion: ctDNA monitoring was meaningful in high-risk patients. Moreover, ctDNA and wellknown prognostic factors should be considered in the decision making for auto-SCT. If a new genetic mutation in ctDNA with a negative prognosis would emerge during treatment, high risk patients should consider auto-SCT. | Kim, Juhyung; Le, Tan Minh; Lee, Donghyeon; Nguyen, Hong Duc Thi; Cho, Hee Jeong; Sohn, Sang Kyun; Kim, Jong Gwang; Jeong, Shin-young; Ham, Ji Yeon; Jeong, Ji Yun; Han, Hyung Soo; Moon, Joon Ho; Baek, Dong Won | Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Hematol Oncol, Daegu, South Korea; Kyungpook Natl Univ, Grad Sch, Dept Biomed Sci, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Program BK21 4, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Nucl Med, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Lab Med, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Pathol, Daegu, South Korea; Kyungpook Natl Univ Chilgok Hosp, Chilgok Hosp, Sch Med, Dept Hematol Oncol, 807,Hoguk Ro, Daegu 41404, South Korea | ; Le, Tan/ITT-2150-2023 | 58739544500; 57870749600; 57870503500; 57870555300; 57216754907; 13310226800; 59501049300; 36164032500; 56464754800; 57205472984; 7401969388; 56568642700; 57191874272 | jhmoon@knu.ac.kr;baekdw83@gmail.com; | IN VIVO | IN VIVO | 0258-851X | 1791-7549 | 38 | 1 | SCIE | MEDICINE, RESEARCH & EXPERIMENTAL | 2024 | 1.8 | 70.5 | 0.49 | 2025-04-16 | 0 | 2 | Circulating-tumor DNA; diffuse large B-cell lymphoma; stem cell transplantation; survival | DISEASE | Circulating-tumor DNA; diffuse large B-cell lymphoma; stem cell transplantation; survival | Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; DNA; Doxorubicin; Hematopoietic Stem Cell Transplantation; Humans; Lymphoma, Large B-Cell, Diffuse; Middle Aged; Neoplasm Recurrence, Local; Pilot Projects; Prednisone; Prognosis; Stem Cell Transplantation; Transplantation, Autologous; Vincristine; busulfan; circulating tumor DNA; cyclophosphamide; doxorubicin; etoposide; prednisone; rituximab; vincristine; antineoplastic agent; cyclophosphamide; DNA; doxorubicin; prednisone; vincristine; adult; aged; Article; autologous stem cell transplantation; blood sampling; cancer chemotherapy; cancer patient; cancer prognosis; cancer recurrence; case report; clinical article; clinical outcome; comparative study; controlled study; diffuse large B cell lymphoma; disease course; female; gene mutation; genotype; genotyping; high risk population; human; International Prognostic Index; low risk population; male; metabolic tumor volume; middle aged; multiple cycle treatment; pilot study; positron emission tomography; treatment response; autotransplantation; diffuse large B cell lymphoma; genetics; hematopoietic stem cell transplantation; prognosis; stem cell transplantation; tumor recurrence | English | 2024 | 2024 (JAN-FEB) | 10.21873/invivo.13448 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Decreased SMP30 Expression Is Related With EMT in the Kidneys of Two Siberian Tigers With CKD | Background/Aim: Chronic kidney disease (CKD) is one of the most common causes of mortality in wild non domestic felidae. The molecular mechanism regulating renal fibrosis in nephropathy is not fully understood especially in the felidae. This study aimed to elucidate senescence marker protein 30 (SMP30) expression patterns and its relationship with epithelial-mesenchymal transition (EMT) by immunostaining in two necropsied Siberian tigers (Panthera tigris altaica) with CKD. Materials and Methods: Two kidney samples from male Siberian tigers were fixed and tissue sections were stained for histopathological assay. Results: In CKD, renal tubular epithelial cells lost their tubular structures surrounded by severe interstitial fibrosis and were detached from the basement membrane. These damaged cells resembled the morphology of mesenchymal cells and showed much lower SMP30 expression compared with intact tubular epithelial cells. These cells also expressed vimentin, which is specifically expressed by mesenchymal cells, and through double staining, it was observed that vimentin was expressed in the tubular epithelial cells where SMP30 was not expressed. In addition, double-positive expression of pan-cytokeratin (pan-CK) and vimentin was found in damaged epithelial cells with mesenchymal features. Conclusion: We demonstrated possible evidence to understand the role of SMP30 as a new pivotal factor and the possibility of decreased SMP30 as a potential indicator of EMT at the end stage of CKD. | Jung, Yi-rang; Yim, Jae-hyuk; Lee, Young-jin; Lee, Sae-bom; Heo, Sung-yong; Bae, Seul-gi; Kim, Kyoo-tae; Kwon, Young-sam; Park, Sang-joon; Park, Jin-kyu; Kim, Tae-hwan | Kyungpook Natl Univ, Coll Vet Med, Dept Vet Pathol, Daegu, South Korea; Daegu Hlth Coll, Dept Compan Anim Hlth Management, Daegu, South Korea; Siberian Tiger Conservat Ctr, Baekdudaegan Natl Arboretum, Bonghwa, South Korea; Kyungpook Natl Univ, Coll Vet Med, Daegu, South Korea; Kyungpook Natl Univ, Coll Vet Med, Dept Vet Pathol, Daegu 41566, South Korea; Siberian Tiger Conservat Ctr, Baekdudaegan Natl Arboretum, Bonghwa 36209, South Korea | Lee, Hyun Woo/AAH-8473-2020 | 7402506505; 57221330255; 57491815500; 58785224700; 58785399900; 55418865900; 56680415000; 7403459426; 7501825941; 35213723500; 57202984578 | jinkyu820@knu.ac.kr;thkim56@koagi.or.kr; | IN VIVO | IN VIVO | 0258-851X | 1791-7549 | 38 | 1 | SCIE | MEDICINE, RESEARCH & EXPERIMENTAL | 2024 | 1.8 | 70.5 | 0 | 2025-04-16 | 0 | 0 | Chronic kidney disease; epithelial-mesenchymal transition; senescence marker protein 30; Siberian tiger | EPITHELIAL-MESENCHYMAL TRANSITION; DIABETIC-NEPHROPATHY; DOWN-REGULATION; SENESCENCE; REGUCALCIN; INJURY; CELLS; LIVER | Chronic kidney disease; epithelial–mesenchymal transition; senescence marker protein 30; Siberian tiger | Animals; Epithelial-Mesenchymal Transition; Felidae; Fibrosis; Humans; Kidney; Male; Renal Insufficiency, Chronic; Tigers; Vimentin; cytokeratin; pan cytokeratin; regucalcin; unclassified drug; vimentin; animal cell; animal tissue; antineoplastic activity; Article; autopsy; bacterium identification; basement membrane; cancer inhibition; Candida albicans; chronic kidney failure; clinical feature; Clostridium perfringens; disease association; disease severity; Enterococcus faecalis; epithelial mesenchymal transition; epithelium cell; Escherichia coli; fibrosing alveolitis; histopathology; immunofluorescence; immunohistochemistry; immunoreactivity; kidney; kidney epithelium; kidney fibrosis; kidney tubule cell; male; matrix-assisted laser desorption-ionization mass spectrometry; mesenchyme cell; nonhuman; protein expression; Proteus mirabilis; Siberian tiger; staining; Streptococcus; Streptococcus minor; tiger; time of flight mass spectrometry; tissue section; animal; epithelial mesenchymal transition; Felidae; fibrosis; genetics; human; kidney | English | 2024 | 2024 (JAN-FEB) | 10.21873/invivo.13429 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Diagnostic Usefulness of p53 Immunostaining in Gastric Cancer and Dysplasia: A Real-world Clinical Experience | Background/Aim: Gastric cancer and its precancerous lesions represent a significant public health concern. A subset of gastric cancers exhibits mutations in the TP53 gene, often accompanying distinctive morphologic alterations. This study aimed to assess the diagnostic efficacy of p53 immunostaining in real-world clinical settings. Patients and Methods: A retrospective analysis was conducted on 50 cases of gastric tumors and tumor-like lesions, wherein p53 immunostaining played a pivotal diagnostic role. The staining pattern of p53 was examined in conjunction with clinicopathologic parameters. Results: Mutant p53 staining pattern demonstrated a significant association with high-grade nuclear atypia (p<0.001), highgrade dysplasia, and tubular adenocarcinoma (p<0.001), as well as microsatellite instability status (p=0.034). Furthermore, the diagnostic utility of p53 immunostaining was evident in scenarios where: 1) biopsy specimens contained few tumor cells, 2) pathologic evaluation of resection margins was limited by cauterization artifacts, and 3) distinction between low-grade and high-grade gastric dysplasia was challenging. Conclusion: P53 immunostaining can be helpful for the diagnosis of gastric tumor and tumorlike lesions, and accurate pathologic margin evaluation, | Park, Ji Hyun; Seo, An Na; Kim, Moonsik | Yonsei Univ, Dept Pathol, Coll Med, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pathol, Daegu, South Korea | Park, Ji/ABG-5893-2020 | 59284110500; 55804153700; 57195918515 | san0729@naver.com;teiroa83@knu.ac.kr; | IN VIVO | IN VIVO | 0258-851X | 1791-7549 | 38 | 4 | SCIE | MEDICINE, RESEARCH & EXPERIMENTAL | 2024 | 1.8 | 70.5 | 0.44 | 2025-05-07 | 3 | 3 | p53; immunohistochemistry; gastric cancer; gastric dysplasia; stomach biopsy; resection margin evaluation | IMMUNOHISTOCHEMICAL STAINING PATTERNS; ENDOSCOPIC MUCOSAL RESECTION; FOR-MOLECULAR-PATHOLOGY; MUTANT P53; BREAST-CANCER; TP53 MUTATION; EXPRESSION; ASSOCIATION; GUIDELINES; GRADE | gastric cancer; gastric dysplasia; immunohistochemistry; p53; resection margin evaluation; stomach biopsy | Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Female; Humans; Immunohistochemistry; Male; Microsatellite Instability; Middle Aged; Mutation; Neoplasm Grading; Precancerous Conditions; Retrospective Studies; Stomach Neoplasms; Tumor Suppressor Protein p53; protein p53; protein p53; TP53 protein, human; tumor marker; adult; Article; artifact; cancer cell; cancer diagnosis; cancer surgery; cauterization; clinical article; cohort analysis; controlled study; diagnostic accuracy; diagnostic value; dysplasia; endoscopic mucosal resection; endoscopic submucosal dissection; female; histopathology; human; human tissue; immunohistochemistry; male; microsatellite instability; middle aged; retrospective study; stomach adenocarcinoma; stomach biopsy; stomach cancer; stomach carcinoma; stomach disease; surgical margin; aged; cancer grading; diagnosis; genetics; metabolism; mutation; pathology; precancer; stomach tumor; very elderly | English | 2024 | 2024 (JUL-AUG) | 10.21873/invivo.13641 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | External Volume Expansion: Timing and Effects on the Rate of Fat Graft Retention in BALB/c Nude Mice | Background/Aim: Fat grafting has been widely used for soft -tissue augmentation. External volume expansion (EVE) is a favorable tool for improvement in the rate of fat graft retention. However, few studies have focused on the most appropriate time for its implementation. In this study, BALB/c nude mice were used to investigate the effective time for the implementation of external volume expansion to improve the rate of fat retention. Materials and Methods: Sixteen mice were divided into four groups, and EVE was performed at different time points before or both before and after fat grafting. Fat tissue from a human donor was injected into the mice following EVE. Visual assessment, micro -computed tomography analysis, and histopathological evaluation were used to assess fat retention. Results: After 10 weeks, the group that underwent EVE 5 days before fat grafting demonstrated a significantly higher preserved fat volume, as determined by micro -computed tomography (p<0.05). Moreover, the group that received additional EVE after fat grafting exhibited a higher retention rate compared to the groups receiving EVE only before grafting (p<0.05). Histopathological analysis indicated that swelling, edema, and inflammation were more pronounced in the group with EVE immediately before grafting, while angiogenesis and lipogenesis were more active in the group with additional EVE after grafting. Conclusion: EVE is a safe and effective approach for improving the rate of fat graft retentions. Furthermore, the timing of external tissue expansion plays a crucial role in fat retention. Based on our animal study, performing EVE immediately before and after fat grafting may be an effective strategy for enhancing the rate of fat graft retentions. | Chang, Yong june; Kim, Yun hyun; Lee, Joon seok; Ryu, Jeong yeop; Choi, Kang young; Chung, Ho yun; Cho, Byung chae; Yang, Jung dug | Kyungpook Natl Univ, Sch Med, Dept Plast & Reconstruct Surg, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Plast & Reconstruct Surg, 130 Dongdeok Ro, Daegu 41944, South Korea | Yang, Jung/R-7806-2019; LEE, JIN/Q-3108-2018; Ryu, Jeong Yeop/GLQ-9419-2022 | 57949685900; 57212668506; 56496041000; 56366349400; 57203745682; 7404007181; 55662871100; 55171704700 | lambyang@knu.ac.kr; | IN VIVO | IN VIVO | 0258-851X | 1791-7549 | 38 | 2 | SCIE | MEDICINE, RESEARCH & EXPERIMENTAL | 2024 | 1.8 | 70.5 | 0.44 | 2025-05-07 | 1 | 1 | BALB/c nude mice; external volume expansion; fat graft; fat retention rate | BREAST; ANGIOGENESIS; VIABILITY; SURVIVAL | BALB/c nude mice; external volume expansion; fat graft; fat retention rate | Adipose Tissue; Animals; Graft Survival; Humans; Inflammation; Mice; Mice, Nude; X-Ray Microtomography; eosin; fat; hematoxylin; adipogenesis; adipose tissue; adult; angiogenesis; animal experiment; animal tissue; Article; BALB/c nude mouse; controlled study; dermis; donor; edema; external volume expansion; fat graft; female; human; inflammation; lipogenesis; male; micro-computed tomography; mouse; nonhuman; sample; subcutaneous tissue; swelling; three-dimensional imaging; tissue expansion; tissue graft; adipose tissue; animal; graft survival; inflammation; nude mouse; transplantation | English | 2024 | 2024 (MAR-APR) | 10.21873/invivo.13492 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Microsatellite Instability, Epstein-Barr Virus, p53, and β-Catenin in Early Gastric Cancers: Clinicopathologic Association | Background/Aim: Endoscopic submucosal dissection (ESD) effectively treats selected early gastric cancers (EGCs). However, the association of microsatellite instability (MSI), Epstein-Barr virus (EBV), p53, and beta-catenin status with clinicopathologic parameters in EGCs treated with ESD have not been well studied. Patients and Methods: We retrospectively collected 312 consecutive EGC cases treated with ESD from January 2021 to December 2023 at Kyungpook National University Chilgok Hospital. MSI polymerase chain reaction, EBV encoded RNA in situ hybridization, and p53 and beta-catenin immunostaining were performed for all cases. Results: Among 312 EGC cases, there were 42 MSI-High (MSI-H) cases (13.5%), 13 EBV-associated gastric cancer (EBVaGC) cases (4.2%), 249 intestinal type cases (79.8%), and eight poorly cohesive carcinoma cases (2.6%). MSI-H was significantly associated with lymphovascular invasion (p=0.02), local recurrence (p=0.03), and synchronous tumors (p<0.001). More than half of EBVaGC cases showed submucosal invasion (61.5%, 8/13) (p=0.016). Consequently, non-curative ESD was more frequently found in EBVaGC than in other subtypes (p<0.001). Mutant p53 patterns and nuclear translocation of beta-catenin were almost exclusively found in the intestinal type (p<0.001), without association with clinicopathologic parameters. Margin involvement was frequent in poorly cohesive carcinoma (p=0.003). Conclusion: We demonstrated that MSI-H and EBVaGC are strongly associated with clinicopathologic parameters and risk factors in EGCs treated with ESD. Molecular testing of gastric cancers should be considered before ESD for better patient management. | Kim, Jinhee; Choi, Jinyoung; Kwon, Hyuk-Joo; Kim, Moonsik | Kyubgpook Natl Univ, Chilgok Hosp, Dept Pathol, Daegu, South Korea; Kyubgpook Natl Univ, Chilgok Hosp, Dept Gastroenterol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pathol, Daegu, South Korea | 59395443700; 59395507400; 59395475700; 57195918515 | teiroa83@knu.ac.kr; | IN VIVO | IN VIVO | 0258-851X | 1791-7549 | 38 | 6 | SCIE | MEDICINE, RESEARCH & EXPERIMENTAL | 2024 | 1.8 | 70.5 | 0 | 2025-05-07 | 0 | 0 | Early gastric cancer; endoscopic submucosal dissection; microsatellite instability; Epstein-Barr virus; p53; beta-catenin | ENDOSCOPIC SUBMUCOSAL DISSECTION; E-CADHERIN EXPRESSION; SUBTYPES | Early gastric cancer; endoscopic submucosal dissection; Epstein-Barr virus; microsatellite instability; p53; β-catenin | Adult; Aged; Aged, 80 and over; beta Catenin; Endoscopic Mucosal Resection; Epstein-Barr Virus Infections; Female; Herpesvirus 4, Human; Humans; Male; Microsatellite Instability; Middle Aged; Neoplasm Staging; Retrospective Studies; Stomach Neoplasms; Tumor Suppressor Protein p53; beta catenin; protein p53; beta catenin; CTNNB1 protein, human; protein p53; TP53 protein, human; adult; aged; Article; cancer recurrence; cohort analysis; early cancer; endoscopic submucosal dissection; Epstein Barr virus; Epstein-Barr virus-associated gastric carcinoma; female; gastrectomy; human; human tissue; immunohistochemistry; in situ hybridization; intestinal type gastric carcinoma; lymph vessel metastasis; major clinical study; male; microsatellite instability; mutant; polymerase chain reaction; retrospective study; RNA hybridization; stomach cancer; stomach carcinoma; stomach tissue; cancer staging; complication; endoscopic mucosal resection; Epstein Barr virus infection; genetics; metabolism; middle aged; pathology; stomach tumor; surgery; very elderly; virology | English | 2024 | 2024 (NOV-DEC) | 10.21873/invivo.13772 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Postoperative Scar Management Using Laser Therapy for Breast Reconstruction With Latissimus Dorsi Flap | Background: Postoperative scar formation is inevitable, and a gold standard management has not been established to date. Due to the fact long and large scar formation occurs in reconstructive surgery, this study analyzed the relationship between various factors in patients who received breast reconstruction using latissimus dorsi (LD) flap to investigate appropriate and effective management approaches. Patients and Methods: Twentyseven patients who underwent breast reconstruction between June 2014 and January 2015 received laser therapy on their LD donor site at the Kyungpook National University Chilgok Hospital. Scar evaluation was performed on both the surgical scar and intact skin on the contralateral side. Scar evaluation was conducted at five specific points, 2 cm from the midpoint of the scar on each side. Laser treatment was performed at 4 -week intervals, and patients were then followed -up for 6 months. To assess scars, gross images were taken using the same settings. In addition, spectrophotometry was used for color assessment, durometer for texture and pressure evaluation, and Vernier calipers and height gauges for a more precise and objective approach. Results: The mean age of the participants was 45.7 years, and the mean body mass index was 22.1 kg/m2. The operator -evaluated scar scale scores were 107.2 and 97.3 in the experimental and control groups, respectively. In the patient -rated questionnaire, the scores were 62.3 and 59.4 in the experimental and control groups, respectively. Conclusion: When analyzing early -stage postoperative scars based on various factors, laser therapy is considered a very useful scar management approach. Additionally, when performing reconstructive surgery, tension force is regarded as a significant factor to take into account since it affects scar widening. | Lee, Joon Seok; Kang, Hyun Su; Park, Jongmoo; Ryu, Jeong Yeop; Choi, Kang Young; Chung, Ho Yun; Kang, Byeongju; Lee, Jeeyeon; Park, Ho Yong; Yang, Jung Dug | Kyungpook Natl Univ, Sch Med, Dept Plast & Reconstruct Surg, 130 Dongdeok Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Radiat Oncol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Surg, Daegu, South Korea | Ryu, Jeong Yeop/GLQ-9419-2022; PARK, HO-YONG/AAP-2225-2021; Lee, Jong-Mok/KVY-9550-2024; LEE, JIN/Q-3108-2018; Yang, Jung/R-7806-2019 | 56496041000; 58890125800; 56180048900; 56366349400; 57203745682; 7404007181; 57279815300; 37079213100; 56564377200; 55171704700 | lambyang@knu.ac.kr; | IN VIVO | IN VIVO | 0258-851X | 1791-7549 | 38 | 2 | SCIE | MEDICINE, RESEARCH & EXPERIMENTAL | 2024 | 1.8 | 70.5 | 0.44 | 2025-05-07 | 1 | 1 | Laser therapy; scars; pulsed dye lasers; erbium yttrium aluminum garnet lasers | PATHOPHYSIOLOGY; REVISION; KELOIDS | erbium yttrium aluminum garnet lasers; Laser therapy; pulsed dye lasers; scars | Cicatrix; Humans; Laser Therapy; Mammaplasty; Middle Aged; Superficial Back Muscles; Surgical Flaps; Treatment Outcome; local anesthetic agent; manecin; adult; Article; body mass; breast cancer; breast reconstruction; clinical article; controlled study; donor site; elasticity; erythema; female; follow up; hematoma; human; Kyungpook National University Hospital scar scale; laser therapy; latissimus dorsi flap; postoperative care; postoperative hemorrhage; pressure; questionnaire; scar formation; scoring system; seroma; simple mastectomy; skin color; spectrophotometry; texture analysis; volume; weight; back muscle; middle aged; procedures; scar; surgical flaps; treatment outcome | English | 2024 | 2024 (MAR-APR) | 10.21873/invivo.13509 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Preoperative and Postoperative Platelet-Lymphocyte Ratio Is a Prognostic Marker for Patients With Soft Tissue Sarcoma Treated With Curative Resection | Background/Aim: Systemic inflammation has been implicated in the development and progression of cancer. Inflammatory markers have been identified as prognostic indicators in numerous malignancies. This study explored the prognostic relevance of the initial and postoperative neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) on relapse-free survival (RFS) and overall survival (OS) in patients with soft-tissue sarcoma (STS) who underwent curative resection. Patients and Methods: We included 89 patients with STS who underwent extensive and radical resection at the Kyungpook National University Chilgok Hospital between 2004 and 2018. Kaplan-Meier curves for RFS and OS were calculated using multivariate Cox proportional models. Results: A total of 67 (75.3%) patients demonstrated a high initial NLR (>= 4.1) and 65 (75.3%) showed a high initial PLR (>= 231). In the univariate and multivariate analyses, an elevated initial PLR ratio was significantly associated with a decreased RFS (p=0.017) and OS (p=0.003). Patients with a high PLR (PLR >231) had a median RFS of 24 months, whereas those with a low PLR (PLR <= 231) had a median RFS of 96 months. The median OS was 50 and 298 months for the high PLR and low PLR groups, respectively. Furthermore, a high postoperative PLR ratio was associated with a decreased RFS (p=0.001) and OS (p=0.038). Conclusion: Preoperative and postoperative PLR ratio can be used as a cost-effective prognostic marker for oncologic outcomes in patients with STS who undergo surgery. | Lee, In Hee; Na, Jihyun; Lee, Soo Jung | Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Oncol Hematol,Canc Res Inst, Daegu, South Korea; Ulsan Univ Hosp, Ulsan Med Sch, Dept Hematol & Oncol, Ulsan, South Korea | 57191881516; 59196069900; 57203597252 | majestio@hanmail.net; | IN VIVO | IN VIVO | 0258-851X | 1791-7549 | 38 | 4 | SCIE | MEDICINE, RESEARCH & EXPERIMENTAL | 2024 | 1.8 | 70.5 | 0.44 | 2025-05-07 | 2 | 2 | Soft-tissue sarcoma; PLR; prognostic marker | SOLID TUMORS; SURVIVAL; NEUTROPHIL; CANCER; INFLAMMATION; METASTASIS; MONOCYTE; COUNT | PLR; prognostic marker; Soft-tissue sarcoma | Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Blood Platelets; Female; Humans; Kaplan-Meier Estimate; Lymphocyte Count; Lymphocytes; Male; Middle Aged; Neutrophils; Platelet Count; Postoperative Period; Preoperative Period; Prognosis; Sarcoma; Young Adult; biological marker; tumor marker; adult; aged; antineoplastic activity; Article; cancer inhibition; female; human; major clinical study; male; neutrophil lymphocyte ratio; overall survival; platelet lymphocyte ratio; radical resection; recurrence free survival; soft tissue sarcoma; surgery; blood; Kaplan Meier method; lymphocyte; lymphocyte count; middle aged; mortality; neutrophil; pathology; platelet count; postoperative period; preoperative period; prognosis; sarcoma; thrombocyte; very elderly; young adult | English | 2024 | 2024 (JUL-AUG) | 10.21873/invivo.13663 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Protective Effects of Imatinib on a DSS-induced Colitis Model Through Regulation of Apoptosis and Inflammation | Background/Aim: Inflammatory bowel disease (IBD) is characterized by dysregulated immune responses and a multifactorial etiology. While imatinib has demonstrated efficacy in the treatment of immune-related diseases, its potential effects in IBD treatment remain underexplored. Materials and Methods: This study aimed to investigate the therapeutic effects of imatinib in colitis treatment. A dextran sulfate sodium (DSS)-induced colitis model was used to mimic IBD in mice. Imatinib was administered orally to mice simultaneously with DSS treatment. The effects of imatinib on DSS-induced colitis were evaluated by analyzing colitis-related pathology, including the disease activity index (DAI), histological lesions, inflammatory markers, and tight junction integrity. Additionally, western blot analysis and quantitative real-time polymerase chain reaction were used to assess inflammatory markers, tight-junction proteins, and cell death. Results: In the DSS-induced colitis model, imatinib treatment exerted protective effects by attenuating weight loss, restoring colon length, reducing spleen weight, and improving the DAI score and histological lesions. Additionally, imatinib reduced the level of proinflammatory cytokines, including TNF alpha , IL-6, and IL-1 beta. beta . Furthermore, imatinib treatment restored tight-junction integrity and decreased the expression of apoptosis marker proteins. Conclusion: Overall, imatinib treatment significantly alleviated the symptoms of DSS-induced colitis by influencing the expression of proinflammatory cytokines, tight junction proteins, and apoptotic markers in mice. These findings highlight imatinib as a potential therapeutic candidate for IBD. | Kim, Hyeonjin; Kim, Chae Yeon; Kim, Dongwook; Kim, Eungyung; Ma, Lei; Park, Kanghyun; Liu, Zhibin; Huang, Ke; Wen, Weihong; Ko, Jiwon; Lim, Su-Geun; Sung, Younghun; Ryoo, Zae Young; Yi, Jun Koo; Jang, Soyoung; Kim, Myoung Ok | Kyungpook Natl Univ, Res Inst Innovat Anim Sci, Dept Anim Sci & Biotechnol, Sangju, South Korea; Kyungpook Natl Univ, Dept Dent Hyg, Sangju, South Korea; Northwestern Polytech Univ, Inst Med Res, Xian, Peoples R China; Kyungpook Natl Univ, Sch Life Sci & Biotechnol, Coll Nat Sci, Daegu, South Korea; Daegu Gyeongbuk Med Innovat Fdn DGMIF, Preclin Res Ctr, Daegu, South Korea; Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat BioRes Grp, Daegu, South Korea; Hankyong Natl Univ, Sch Anim Life Convergence Sci, Anseong, South Korea | RYOO, ZAEYOUNG/AAQ-1573-2020 | 57343180400; 57966906800; 57193414967; 57217871658; 57217867673; 58530860300; 58640210100; 58639636600; 7102171031; 57226659428; 56044587400; 59305058400; 16937104900; 56182537200; 57139360300; 8934745900 | jangsy@knu.ac.kr;ok4325@knu.ac.kr; | IN VIVO | IN VIVO | 0258-851X | 1791-7549 | 38 | 5 | SCIE | MEDICINE, RESEARCH & EXPERIMENTAL | 2024 | 1.8 | 70.5 | 0 | 2025-05-07 | 1 | 1 | Inflammatory bowel disease; imatinib; tight junction; inflammation; apoptosis | ULCERATIVE-COLITIS; BOWEL-DISEASE; MESYLATE | apoptosis; imatinib; inflammation; Inflammatory bowel disease; tight junction | Animals; Apoptosis; Biomarkers; Colitis; Cytokines; Dextran Sulfate; Disease Models, Animal; Imatinib Mesylate; Inflammation; Inflammation Mediators; Male; Mice; imatinib; interleukin 1beta; interleukin 6; tight junction protein; tumor necrosis factor; autacoid; biological marker; cytokine; dextran sulfate; imatinib; animal experiment; animal model; animal tissue; antiapoptotic activity; antiinflammatory activity; apoptosis; Article; body weight loss; colon tissue; controlled study; dextran sulfate sodium-induced colitis; disease activity; drug efficacy; histology; inflammation; inflammatory bowel disease; male; mouse; nonhuman; real time polymerase chain reaction; regulatory mechanism; spleen weight; tight junction; Western blotting; animal; colitis; disease model; drug effect; drug therapy; inflammation; metabolism; pathology | English | 2024 | 2024 (SEP-OCT) | 10.21873/invivo.13696 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | RaepenolTM Cream, a Complex of Natural Compounds, Promotes Wound Healing and Relieves Pruritus In Vivo | Background/Aim: Skin wound healing is a physiological process restoring the structural and functional integrity of injured skin. During this process, wound management preventing bacterial infection and complications is important for the regeneration of skin layers and adnexa, as well as the protective function of the skin. Therefore, the development of an effective ointment to promote wound healing without complications is beneficial. Materials and Methods: This study developed RaepenolTM cream, comprising a base cream and natural compounds including paeonol, D-panthenol and extract of Centella asiatica, and assessed its therapeutic effect in wound healing. A rat model of skin wound healing and a mouse model of imiquimod-induced pruritus were employed. The effect of RaepenolTM cream was evaluated by wound size and histological analysis, including the integrity of skin structures and inflammatory response. Results: RaepenolTM cream treatment effectively restored the structural integrity of the skin in rats, including wound closure, regeneration of skin adnexa, and reconstitution of collagen, comparable to commercial ointment. Additionally, RaepenolTM cream significantly suppressed pruritus by inhibiting mast cell infiltration or retention in the inflammatory site of mouse ears. Conclusion: RaepenolTM cream effectively promoted wound healing and relieved pruritus in animal models. These results suggest that it could be a promising option for wound care and pruritus relief, offering potential advantages over current ointments. | Kim, Eungyung; Cho, Na Eun; Park, Sijun; Kim, Hong-Gyum; Yi, Junkoo; Kim, Hyeonjin; Ma, Lei; Huang, Ke; Liu, Zhibin; Kim, Chae Yeon; Park, Kanghyun; Sung, Yonghun; Jang, Soyoung; Jang, Soyeon; Choi, Seong-Kyoon; Ryoo, Zae Young; Lim, Su-Geun; Kim, Myoung Ok | Kyungpook Natl Univ, Res Inst Innovat Anim Sci, Dept Anim Sci & Biotechnol, Sangju, South Korea; Korea Inst Ocean Sci & Technol KIOST, East Sea Environm Res Ctr, Uljin, South Korea; GentriBIO Inc, R&D Ctr, Chunchon, South Korea; Hankyong Natl Univ, Sch Anim Life Convergence Sci, Anseong, South Korea; Daegu Gyeongbuk Med Innovat Fdn K MEDIHub, Preclin Res Ctr, Daegu, South Korea; Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat Biores Grp, Daegu 41566, South Korea; DGIST, Core Prot Resources Ctr, Daegu, South Korea | Yi, Junkoo/JBR-8507-2023; RYOO, ZAEYOUNG/AAQ-1573-2020 | 57217871658; 57804013400; 54682212300; 59304917200; 56182537200; 57343180400; 57217867673; 58639636600; 58640210100; 57966906800; 58530860300; 58903739800; 57139360300; 57226661947; 55505432500; 16937104900; 56044587400; 8934745900 | sugeun624@knu.ac.kr;ok4325@knu.ac.kr; | IN VIVO | IN VIVO | 0258-851X | 1791-7549 | 38 | 5 | SCIE | MEDICINE, RESEARCH & EXPERIMENTAL | 2024 | 1.8 | 70.5 | 0.44 | 2025-05-07 | 2 | 1 | Skin wound healing; pruritus; paeonol; D-panthenol; Centella asiatica; RaepenolTM cream | CENTELLA-ASIATICA; CONTACT-DERMATITIS; ANTIOXIDANT; PAEONOL | Centella asiatica; D-panthenol; paeonol; pruritus; Raepenol™ cream; Skin wound healing | Animals; Biological Products; Disease Models, Animal; Male; Mice; Ointments; Pruritus; Rats; Skin; Skin Cream; Wound Healing; Centella asiatica extract; collagen; d panthenol; dexpanthenol; imiquimod; peonol; raepenol; unclassified drug; biological product; skin cream; animal experiment; animal model; animal tissue; Article; controlled study; cream; histopathology; in vivo study; male; mouse; nonhuman; pruritus; rat; therapy effect; wound closure; wound healing; animal; disease model; drug effect; drug therapy; injury; ointment; pathology; pruritus; skin; wound healing | English | 2024 | 2024 (SEP-OCT) | 10.21873/invivo.13697 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Silibinin Mitigates Vanadium-induced Lung Injury via the TLR4/MAPK/NF-ĸB Pathway in Mice | Background/Aim: Silibinin, has been investigated for its potential benefits and mechanisms in addressing vanadium pentoxide (V2O5)-induced pulmonary inflammation. This study explored the anti-inflammatory activity of silibinin and elucidate the mechanisms by which it operates in a mouse model of vanadium-induced lung injury. Materials and Methods: Eight-week-old male BALB/c mice were exposed to V2O5 to induce lung injury. Mice were pretreated with silibinin at doses of 50 mg/kg and 100 mg/kg. Histological analyses were performed to assess cell viability and infiltration of inflammatory cells. The expression of pro-inflammatory cytokines (TNF-alpha, IL-6, IL-1 beta) and activation of the MAPK and NF-kappa B signaling pathways, as well as the NLRP3 inflammasome, were evaluated using real-time PCR, western blot analysis, and immunohistochemistry. Whole blood analysis was conducted to measure white blood cell counts. Results: Silibinin treatment significantly improved cell viability, reduced inflammatory cell infiltration, and decreased the expression of pro-inflammatory cytokines in V2O5-induced lung injury. It also notably suppressed the activation of the MAPK and NF-kappa B signaling pathways, along with a marked reduction in NLRP3 inflammasome expression levels in lung tissues. Additionally, silibinin-treated groups exhibited a significant decrease in white blood cell counts, including neutrophils, lymphocytes, and eosinophils. Conclusion: These findings underscore the potent anti-inflammatory effects of silibinin in mice with V2O5-induced lung inflammation, highlighting its therapeutic potential. The study not only confirms the efficacy of silibinin in mitigating inflammatory responses but also provides a foundational understanding of its role in modulating key inflammatory pathways, paving the way for future therapeutic strategies against pulmonary inflammation induced by environmental pollutants. | Im, Hobin; Kim, Eungyung; Kwon, Hong ju; Kim, Hyeonjin; Ko, Jiwon; Sung, Yonghun; Kim, Sung-hyun; Lee, Eun jung; Kwon, Woo-sung; Ryoo, Zae young; Yi, Junkoo; Park, Si jun; Kim, Myoung ok | Kyungpook Natl Univ, Res Inst Innovat Anim Sci, Dept Anim Sci & Biotechnol, Gyeongsangbuk Do, Sangju Si 37224, South Korea; Pohang Technopk Fdn, Adv Bio Convergence Ctr ABCC, Pohang, South Korea; Kyungpook Natl Univ, Sch Life Sci, BK21 Plus KNU Creat Biores Grp, Daegu, South Korea; Daegu Gyeongbuk Med Innovat Fdn K MEDIHub, Preclin Res Ctr, Daegu, South Korea; Korea Polytech Coll, Dept Biomed Anal, Chungnam, South Korea; Hankyong Natl Univ, Sch Anim Life Convergence Sci, Anseong, South Korea; Korea Inst Ocean Sci & Technol, East Sea Environm Res Ctr, Uljin 36315, South Korea | Kwon, Woo-Sung/J-6731-2019; RYOO, ZAEYOUNG/AAQ-1573-2020 | 57217867362; 57217871658; 57217867533; 57343180400; 57226659428; 58903739800; 59103241900; 57805056000; 54383715800; 16937104900; 56182537200; 54682212300; 8934745900 | sjpark@kiost.ac.kr;ok4325@knu.ac.kr; | IN VIVO | IN VIVO | 0258-851X | 1791-7549 | 38 | 5 | SCIE | MEDICINE, RESEARCH & EXPERIMENTAL | 2024 | 1.8 | 70.5 | 0.44 | 2025-05-07 | 1 | 1 | Silibinin; pulmonary inflammation; anti-inflammatory activity; MAPK pathway; NF-kappa B pathway; NLRP3 inflammasome; pro-inflammatory cytokines | PARTICULATE MATTER; AIR-POLLUTION; P38 MAPK; NF-KB; INFLAMMATION; PENTOXIDE; INHALATION; NLRP3; ACCUMULATION; ACTIVATION | anti-inflammatory activity; MAPK pathway; NF-ĸB pathway; NLRP3 inflammasome; pro-inflammatory cytokines; pulmonary inflammation; Silibinin; vanadium pentoxide (V2O5) | Animals; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Inflammation Mediators; Lung; Lung Injury; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Signal Transduction; Silybin; Silymarin; Toll-Like Receptor 4; Vanadium; cryopyrin; gefitinib; imatinib; immunoglobulin enhancer binding protein; interleukin 1beta; interleukin 6; messenger RNA; mitogen activated protein kinase; mitogen activated protein kinase p38; protein; shogaol; silibinin; stress activated protein kinase; toll like receptor 4; transcription factor RelA; tumor necrosis factor; vanadium; vanadium pentoxide; antiinflammatory agent; autacoid; cytokine; immunoglobulin enhancer binding protein; silibinin; silymarin; toll like receptor 4; vanadium; animal experiment; animal model; animal tissue; antiinflammatory activity; Article; Bagg albino mouse; blood analysis; cell infiltration; cell viability; controlled study; cytokine production; down regulation; drug dose comparison; drug efficacy; drug mechanism; eosinophil count; histopathology; human; human cell; immunohistochemistry; in vitro study; inflammatory cell; inflammatory infiltrate; L-132 cell line; leukocyte count; lung injury; lung parenchyma; lung toxicity; lymphocyte count; male; MAPK signaling; mouse; mRNA expression level; neutrophil count; NF kB signaling; nonhuman; pneumonia; protein expression level; protein phosphorylation; real time polymerase chain reaction; signal transduction; therapy effect; vanadium poisoning; Western blotting; animal; disease model; drug effect; drug therapy; etiology; lung; lung injury; metabolism; pathology | English | 2024 | 2024 (SEP-OCT) | 10.21873/invivo.13681 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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