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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | Article | Currency Bias of Sovereign Wealth Fund Investments | This study provides an alternative explanation for the poor performance of sovereign wealth fund (SWF) investments based on key currency bias. Using the international portfolio rebalancing model and the matched firm data of 18,704 and 8,267 cases of SWFs' cross-border investment during 1999-2017, evidence strongly supports the key currency bias hypothesis for the determination of SWFs' cross-border investments. In sharp contrast to the relationship between the exchange rate and international portfolio flows, the economic rationalefor the currency bias is to provide hedging against the exchange risk of SWFs' cross-border investments by matching the denominated key currency of the SWF sources with the other denominated currency offoreign target assets. This study complements the existing finance literature by providing portfolio implications for analyzing cross-border investments by commercial institution investors and portfolio rebalancing offinancial assets between different currency zones. | Kim, Heeho; Kwon, Sanguk; Seol, Youn | Kyungpook Natl Univ, Sch Econ, Daehak Ro 80, Daegu 41566, South Korea; Korea Rural Econ Inst, Naju, South Korea; Kyungpook Natl Univ, Sch Business Adm, Daehak Ro 80, Daegu 41566, South Korea | Kim, Heeho/AAO-8809-2021 | kimhh@knu.ac.kr;skmdc@umsystem.edu;seoly@knu.ac.kr; | KOREAN ECONOMIC REVIEW | KOREAN ECON REV | 0254-3737 | 38 | 3 | SSCI | ECONOMICS | 2022 | 0.6 | 92.5 | 0 | Sovereign Wealth Fund (SWF); Foreign Bias; Currency Bias; Risk; Hedging | REAL EXCHANGE-RATE; EQUITY HOME BIAS; INSTITUTIONAL INVESTORS; FOREIGN BIAS; DETERMINANTS | English | 2022 | 2022-여름 | 10.22841/kerdoi.2022.38.3.003 | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | Article | Morphology Changes of Maxillary Molar Distalization by Clear Aligner Therapy | & nbsp;To evaluate the skeletal, dento-alveolar and soft tissue morphology changes after maxillary molar distalization by clear aligner therapy and identify the significant efficacy of molar distalization,18 patients in conformity with the inclusion criteria were selected. Pre-and post-treatment Cone Beam Computed Tomography (CBCT) were examined to measure the angular and linear parameters. All subjects were completed non-extraction clear aligner treatment by distalizing molars. A paired-t test and independent-samples t-test were performed to observe the difference between before and after treatment and the difference between the first molar and second molar respectively. P-values < 0.05 were considered statistically significant. Predicted movement rate was calculated by the formula: (actual movement(mm)/planned movement(mm))& times;100%. Most variables of pre-and post-treatment showed no statistical difference(P < 0.05),excepting SNA angle (P < 0.05) and Upper lip/E-line linear (P < 0.01) due to incisor retraction. The first and second molar revealed a translation movement without significant tipping and vertical movement. Clear aligners provided a high predictability (83.44 %) of distalization the maxillary first molar, and 85.14 % of the maxillary second molar. Clear aligners can effectively achieve distal displacement of molars. | Cui, Jia-Yu; Ting, Liu; Cao, Yu-Xin; Sun, Dan-Xu; Bing, Li; Wu, Xiu-Ping | Shanxi Med Univ, Sch Dent, Dept Orthodont, Taiyuan, Peoples R China; Kyungpook Natl Univ, Sch Dent, Dept Orthodont, Daegu, South Korea | Cui, Jiayu/MBG-4114-2025; Li, Bing/CAF-7418-2022 | libing-1975@163.com; | INTERNATIONAL JOURNAL OF MORPHOLOGY | INT J MORPHOL | 0717-9502 | 0717-9367 | 40 | 4 | SCIE | ANATOMY & MORPHOLOGY | 2022 | 0.5 | 92.5 | 8 | KEY WORDS; Morphological characteristics; Clear Aligners; molar distalization; Cone Beam Computed Tomography (CBCT) | HEADGEAR | English | 2022 | 2022-08 | 바로가기 | 바로가기 | |||||||||||
| ○ | Article | Morphology Changes of Maxillary Molar Distalization by Clear Aligner Therapy; [Cambios de la Morfología en la Distalización de Molares Maxilares Mediante Terapia con Alineadores Transparentes] | To evaluate the skeletal, dento-alveolar and soft tissue morphology changes after maxillary molar distalization by clear aligner therapy and identify the significant efficacy of molar distalization,18 patients in conformity with the inclusion criteria were selected. Pre-and post-treatment Cone Beam Computed Tomography (CBCT) were examined to measure the angular and linear parameters. All subjects were completed non-extraction clear aligner treatment by distalizing molars. A paired-t test and independent-samples t-test were performed to observe the difference between before and after treatment and the difference between the first molar and second molar respectively. P-values <0.05 were considered statistically significant. Predicted movement rate was calculated by the formula: (actual movement (mm)/ pl anned movement (mm)) ×100%. Most vari abl es of pre-and post-t reat ment showed no st at i st i cal difference(P<0.05),excepting SNA angle (P<0.05) and Upper lip/E-line linear (P<0.01) due to incisor retraction. The first and second molar revealed a translation movement without significant tipping and vertical movement. Clear aligners provided a high predictability (83.44 %) of distalization the maxillary first molar, and 85.14 % of the maxillary second molar. Clear aligners can effectively achieve distal displacement of molars. © 2022, Universidad de la Frontera. All rights reserved. | Cui, Jia-Yu; Ting, Liu; Cao, Yu-Xin; Sun, Dan-Xu; Bing, Li; Wu, Xiu-Ping | Department of Orthodontics, School of Dentistry, Shanxi Medical University, Taiyuan, China; Department of Orthodontics, School of Dentistry, Shanxi Medical University, Taiyuan, China; Department of Orthodontics, School of Dentistry, Shanxi Medical University, Taiyuan, China; Department of Orthodontics, School of Dentistry, Kyungpook National University, Daegu, South Korea; Department of Orthodontics, School of Dentistry, Shanxi Medical University, Taiyuan, China; Department of Orthodontics, School of Dentistry, Shanxi Medical University, Taiyuan, China | 57915753500; 57914698300; 57915534500; 57218909957; 55875675800; 56415363800 | libing-1975@163.com; | International Journal of Morphology | INT J MORPHOL | 0717-9502 | 0717-9367 | 40 | 4 | SCIE | ANATOMY & MORPHOLOGY | 2022 | 0.5 | 92.5 | 2.41 | 2025-06-25 | 12 | Clear Aligners; Cone Beam Computed Tomography (CBCT); molar distalization; Morphological characteristics | adult; Article; clinical article; controlled study; female; human; male; malocclusion; maxillary first molar; maxillary second molar; middle aged; morphological trait; retrospective study; soft tissue | English | Final | 2022 | 10.4067/s0717-95022022000400920 | 바로가기 | 바로가기 | 바로가기 | |||||||
| ○ | ○ | Article | Rapid Calculation of CGH Using the Multiplication of Down-scaled CGH with Shifted Concave Lens Array Function | Holographic display technology is one of the promising 3D display technologies. However, the large amount of computation time required to generate computer-generated holograms (CGH) is a major obstacle to the commercialization of digital hologram. In various systems such as multi-depth head-up displays with hologram contents, it is important to transmit hologram data in real time. In this paper, we propose a rapid CGH computation method by applying an arraying of a down-scaled hologram with the multiplication of a shifted concave lens function array. Compared to conventional angular spectrum method (ASM) calculation, we achieved about 39 times faster calculation speed for 3840 ?? 2160 pixel CGH calculation. Through the numerical investigation and experiments, we verified the degradation of reconstructed hologram image quality made by the proposed method is not so much compared to conventional ASM. | Lee, Chang-Joo; Lee, Seung-Yeol | Kyungpook Natl Univ, Coll IT Engn, Sch Elect & Elect Engn, Daegu 41566, South Korea | Lee, Chang/L-4545-2013; Lee, Seungwoo/U-8056-2017 | 57218278895; 55881869300 | seungyeol@knu.ac.kr; | CURRENT OPTICS AND PHOTONICS | CURR OPT PHOTONICS | 2508-7266 | 2508-7274 | 6 | 1 | SCIE | OPTICS | 2022 | 0.6 | 92.5 | 0 | 2025-06-25 | 0 | 0 | Computer-generated holograms generation algorithm; Digital holography; Image processing | COMPUTER-GENERATED HOLOGRAM; RESOLUTION; EFFICIENT; WAVE | Computer-generated holograms generation algorithm; Digital holography; Image processing | Computer generated holography; Electron holography; Holographic displays; Lithography; Numerical methods; Optical data processing; Real time systems; Spectrum analysis; Three dimensional displays; 3D display technologies; Angular spectrum method; Computer-generated hologram generation algorithm; Computergenerated holograms (CGH); Concave lens; Digital holography; Display technologies; Generation algorithm; Images processing; Lens array; Holograms | English | 2022 | 2022-02 | 10.3807/copp.2022.6.1.051 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Operator Means of Lower Triangular Matrices | We show that every Kubo-Ando operator mean of positive definite operators exists on the solvable Lie group of lower triangular matrices with positive diagonal entries. In particular, we show that the operator geometric mean of such lower triangular matrices appears as the common limit of the iteration process of the arithmetic and harmonic means. We further show that the iteration terminates in the finite number inverted right perpendicularlog(2) minverted left perpendicular of iterations for m x m lower unitriangular matrices and present its entrywise closed form for m <= 4. | Choi, Hayoung; Lim, Yongdo | Kyungpook Natl Univ, Dept Math, Daegu, South Korea; Sungkyunkwan Univ, Dept Math, Suwon, South Korea | Choi, Hayoung/U-7046-2019 | 56942685000; 55931749600 | hayoung.choi@knu.ac.kr;ylim@skku.edu; | JOURNAL OF LIE THEORY | J LIE THEORY | 0949-5932 | 32 | 1 | SCIE | MATHEMATICS | 2022 | 0.4 | 92.6 | 0.75 | 2025-06-25 | 2 | 2 | Operator mean; geometric mean; lower triangular matrix; nilpotent Lie group; Newton's square root algorithm | CONCAVITY | geometric mean; lower triangular matrix; Newton’s square root algorithm; nilpotent Lie group; Operator mean | English | 2022 | 2022 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | THREE KINDS OF NUMERICAL INDICES lp-SPACES | In this paper, we investigate the polynomial numerical index n((k))(l(p)), the symmetric multilinear numerical index n(s)((k))(l(p)), and the multilinear numerical index n(m)((k))(l(p)) of l(p) spaces, for 1 = 2. We show that for 1 infinity)n(I)((k))(l(p)(j)), for every I = s, m, where l(p)(j) = (C-j, parallel to center dot parallel to(p)) or (R-j, parallel to center dot parallel to(p)). We also show the following inequality between n(s)((k))(l(p)(j)) and n((k))(l(p)(j)): let 1 0 : parallel to Q parallel to infinity)n(s)((j))(l(p)) = lim(j ->infinity)n(m)((j))(l(p)) = 0, for every 1 < p < infinity. | Kim, Sung Guen | Kyungpook Natl Univ, Dept Math, Daegu 702701, South Korea | 34769667700 | sgk317@knu.ac.kr; | GLASNIK MATEMATICKI | GLAS MAT | 0017-095X | 1846-7989 | 57 | 1 | SCIE | MATHEMATICS, APPLIED;MATHEMATICS | 2022 | 0.4 | 92.6 | 0.74 | 2025-06-25 | 3 | 3 | The polynomial numerical index; the symmetric multilinear numerical index; the multilinear numerical index | BANACH-SPACES | the multilinear numerical index; The polynomial numerical index; the symmetric multilinear numerical index | English | 2022 | 2022-06 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Pulmonary vein stump thrombosis after lung resection for lung cancer: clinical features and outcome | Pulmonary vein stump thrombosis (PVST) is uncommonly encountered postoperative in-situ thrombosis in the stump of pulmonary veins after lung resection. Data regarding the incidence and clinical behaviour of PVST are scarce. Thus, this study aims to investigate the incidence, clinical characteristics and outcome of PVST after lung resection in patients with lung cancer. Follow-up enhanced chest computed tomography (CT) scans acquired after the surgery were retrospectively reviewed to determine PVST presence for patients with lung cancer who underwent lung resection in two tertiary referral centres. Out of the 1885 patients with lung cancer who underwent lobectomy or more extensive lung resection, PVST was observed in 37 patients (2.0%) on their follow-up chest CT. Most stump thrombi were observed in the left superior pulmonary vein [35 (94.6%)] and in patients who underwent left upper lobectomy [34 (91.9%)]. At the last CT follow-up of each patient, 33 (89.2%) exhibited complete resolution, three partial resolution and one stabilization. Eleven (29.7%) patients received anticoagulant therapy after the diagnosis. The rate of complete PVST resolution did not differ significantly between the anticoagulation and nonanticoagulation groups. None of the PVST patients experienced systemic embolic events, regardless of anticoagulation. The PVST incidence diagnosed at routine chest CT follow-up following lung cancer surgery was 2%. PVST was characterized by a benign clinical course without progression and systemic embolization, regardless of anticoagulation. However, further studies are required to determine individualized therapeutic strategies, including anticoagulation. | Park, Ji-Eun; Cha, Seung-Ick; Lee, Deok Heon; Lee, Eung Bae; Choi, Sun Ha; Lee, Yong Hoon; Seo, Hyewon; Yoo, Seung-Soo; Lee, Shin-Yup; Lee, Jaehee; Kim, Chang-Ho; Park, Jae-Yong | Kyungpook Natl Univ, Dept Internal Med, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Thorac & Cardiovasc Surg, Daegu, South Korea | Lee, Junseong/T-4139-2017; Lee, Jaehee/S-1697-2018; Choi, Sun Ha/HPD-7234-2023 | 57195437358; 35227126400; 39561353900; 55664096100; 57199723585; 57199022948; 55612130200; 56479781600; 49863712700; 13805476000; 7409873555; 58360293800 | sicha@knu.ac.kr; | BLOOD COAGULATION & FIBRINOLYSIS | BLOOD COAGUL FIBRIN | 0957-5235 | 1473-5733 | 33 | 6 | SCIE | HEMATOLOGY | 2022 | 1.1 | 93.0 | 0.26 | 2025-06-25 | 3 | 4 | computed tomography; lung cancer; pulmonary vein; surgery; thrombosis | LEFT UPPER LOBECTOMY; MOLECULAR-WEIGHT HEPARIN | computed tomography; lung cancer; pulmonary vein; surgery; thrombosis | Anticoagulants; Humans; Lung; Lung Neoplasms; Pulmonary Veins; Retrospective Studies; Venous Thrombosis; anticoagulant agent; apixaban; edoxaban; rivaroxaban; warfarin; anticoagulant agent; adult; aged; anticoagulant therapy; cancer patient; cancer surgery; clinical article; clinical feature; clinical outcome; computer assisted tomography; controlled study; disease course; female; follow up; human; incidence; lobectomy; lung cancer; male; pneumonectomy; postoperative complication; pulmonary vein; pulmonary vein stump thrombosis; pulmonary vein thrombosis; retrospective study; Review; tertiary care center; thorax radiography; lung; lung tumor; pulmonary vein; vein thrombosis | English | 2022 | 2022-09 | 10.1097/mbc.0000000000001138 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Jageum-Jung, the herbal pharmaceuticals, inhibits the hepatic fibrogenesis as mediated with TGF-β1/smad signaling | Background Herbal prescriptions have various effects and their efficacy is potentiated by the use of combinations of medicinal herbs. Objective Jageum-Jung (JGJ) is a traditional oriental medical prescription composed of five herbs. It has been used for detoxification, and as an anti-inflammatory and antitumor agent. However, the effect of JGJ on hepatic fibrogenesis is unclear. Results We investigated the role of JGJ in TGF-beta 1/smad signaling, which is implicated in fibrogenesis, and its hepatoprotective effect in CCl4-treated mice with liver fibrosis. Treatment of LX-2 cells with TGF-beta induced expression of mediators (alpha-SMA, PAI-1, and MMP-2) of fibrogenesis and activation of proinflammatory cytokines (TNF-alpha, IL-1 beta, and IL-6). However, these were downregulated by pretreatment with JGJ. In mice, oral administration of JGJ prevented liver injury induced by CCl4, as indicated by decreases in the ALT and AST levels. Conclusions JGJ inhibits hepatic fibrogenesis and TGF-beta 1/Smad signaling. | Song, Yu Rim; Jang, Mi Hee; Jang, Boyun; Bae, Su Jin; Bak, Seon Been; Lee, Sung Min; Yun, Un-Jung; Lee, Ju Hee; Park, Sang Mi; Jung, Dae Hwa; Sa, Bok Suk; Song, Jong Kuk; Lee, Eun Hye; Kim, Kwang Youn; Park, Kwang-Il; Kim, Young Woo; Kim, Sang Chan | Daegu Haany Univ, Coll Oriental Med, Gyongsan 38610, South Korea; Dongguk Univ, Sch Korean Med, Gyeongju 38066, South Korea; D&B Bio, Chang Won 51765, South Korea; Chung Shin Herbal Med, Daegu 41933, South Korea; Yong In Univ, Yongin 17092, South Korea; Kyungpook Natl Univ, Sch Med, Daegu 41566, South Korea; Korea Inst Oriental Med, Daegu 41062, South Korea; Gyeongsang Natl Univ, Coll Vet Med, Jinju 52828, South Korea | Lee, Sang Jin/S-4056-2019; Kim, Sang Chan/IUQ-5763-2023 | 57437229000; 57192371693; 57456039300; 57437662600; 57455566300; 57455104900; 6603356818; 56517127000; 55554263000; 57040484500; 57455255800; 57456199100; 57189661699; 58076309300; 55722171100; 55699527800; 8960688000 | ywk@donguk.ac.kr;sckim@dhu.ac.kr; | MOLECULAR & CELLULAR TOXICOLOGY | MOL CELL TOXICOL | 1738-642X | 2092-8467 | 18 | 2 | SCIE | TOXICOLOGY | 2022 | 1.7 | 93.1 | 0.41 | 2025-06-25 | 3 | 3 | Herbal pharmaceutical; Jageum-Jung; Liver fibrosis; TGF-beta 1/smad | STELLATE CELLS; TGF-BETA; EXPRESSION; LIVER; FIBROSIS; MODELS; PAI-1 | Herbal pharmaceutical; Jageum-Jung; Liver fibrosis; TGF-β1/smad | alanine aminotransferase; alpha smooth muscle actin; aspartate aminotransferase; carbon tetrachloride; Chinese medicinal formula; gelatinase A; interleukin 1beta; interleukin 6; jageum jung; liver protective agent; messenger RNA; plasminogen activator inhibitor 1; Smad protein; transforming growth factor beta1; tumor necrosis factor; unclassified drug; alanine aminotransferase blood level; animal cell; animal experiment; animal model; animal tissue; Article; aspartate aminotransferase blood level; blood chemistry; carbon tetrachloride-induced liver fibrosis; cell viability; controlled study; down regulation; enzyme linked immunosorbent assay; fibrogenesis; genetic transfection; herbal medicine; human; human cell; human cell culture; immunoblotting; immunohistochemistry; liver cell; liver protection; luciferase assay; LX-2 cell line; male; mouse; mRNA expression level; MTT assay; nonhuman; prescription; protein expression; real time polymerase chain reaction; Smad signaling; stellate cell line; TGF beta signaling | English | 2022 | 2022-04 | 10.1007/s13273-021-00196-9 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Regulation of mast cell activation by extracellular vesicles in cow's milk casein-induced allergic responses | Background Food allergy is a hypersensitive immune reaction to food proteins including cow's milk protein. Extracellular vesicles (EVs), such as exosomes, are newly discovered intercellular conveyors of functional molecular mechanisms and mediated intercellular interactions involving mast cells and are particularly relevant to allergy. Objective In this study, we investigated whether cow's milk casein-induced allergy (CIA)-derived EVs can modulate mast cell activation. Results EVs in CIA mice and control mice were isolated using the ultracentrifugation method and the isolated EVs were quantified using BCA analysis. CIA responses were determined through changes in body temperature and systemic symptom score. The number of EVs was higher in CIA-derived EVs compared to normal EVs. EVs marker proteins such as CD63 and CD9 were elevated in CIA-derived EVs. The levels of EV-associated cytokines such as IL-6, IL-8, and TNF-alpha were significantly elevated in CIA-derived EVs. In addition, CIA-derived EVs significantly induced degranulation via Lyn kinase activation in mouse bone marrow-derived mast cells and human mast cells. Conclusion Our results demonstrate that CIA-derived EVs can induce a reaction similar to cow's milk allergic reaction via mast cell activation. These results provide an insight into the pathology of cow's milk allergy and a potential therapeutic approach through targeting EV release and/or uptake. | Cho, Young-Eun; Kim, Hyun-Woo; Min, Keun Young; Hwang, Jin-Hyeon; Kim, Dong-Ha; Kim, Jee-In; Yin, Guo Nan; Lim, Jae-Hwan; Kwun, In-Sook; Baek, Moon-Chang; Kim, Do-Kyun | Andong Natl Univ, Dept Food & Nutr, Andong 36729, South Korea; Jeonbuk Natl Univ, Korea Zoonosis Res Inst, Iksan 54531, South Korea; Konkuk Univ, Dept Immunol, Coll Med, Chungju 27478, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biochem & Cell Biol, Daegu 41944, South Korea; Inha Univ, Natl Res Ctr Sexual Med & Dept Urol, Sch Med, Incheon, South Korea; Andong Natl Univ, Dept Biol Sci, Andong 36729, South Korea; Kyungpook Natl Univ, Sch Med, Dept Mol Med, CMRI, Daegu 41944, South Korea | ; yin, guonan/Y-7405-2019; Kim, Woo/D-2733-2015; Kim, Dongha/HNO-9659-2023 | 56390104900; 59656812200; 57200183621; 57219012305; 57219014701; 59088720100; 36574238600; 17035476100; 6602312720; 7006013097; 57442742600 | mcbaek@knu.ac.kr;dkkim714@jbnu.ac.kr; | MOLECULAR & CELLULAR TOXICOLOGY | MOL CELL TOXICOL | 1738-642X | 2092-8467 | 18 | 2 | SCIE | TOXICOLOGY | 2022 | 1.7 | 93.1 | 0.14 | 2025-06-25 | 1 | 1 | Extracellular vesicles (EVs); Food allergy; Cow's milk allergy (CMA); Mast cells; Casein-induced allergy (CIA) | T-CELLS; ANAPHYLAXIS; EXOSOMES; IGE; EXPRESSION; MODEL | Casein-induced allergy (CIA); Cow’s milk allergy (CMA); Extracellular vesicles (EVs); Food allergy; Mast cells | casein; CD63 antigen; CD81 antigen; CD9 antigen; immunoglobulin A antibody; immunoglobulin E antibody; immunoglobulin G1 antibody; immunoglobulin G2a antibody; interleukin 6; interleukin 8; protein kinase Lyn; tumor necrosis factor; animal cell; animal experiment; animal model; Article; bone marrow derived mast cell; cell activation; controlled study; cow milk; cow milk casein induced milk allergy; digital technology; disease severity; enzyme activation; enzyme linked immunosorbent assay; exosome; human; human cell; immunoblotting; immunoglobulin blood level; in vitro study; male; mast cell; mast cell degranulation; milk allergy; mouse; nonhuman; pathogenesis; rectal temperature; ultracentrifugation | English | 2022 | 2022-04 | 10.1007/s13273-021-00182-1 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | The antitumor effect of natural killer cells against hepatocellular carcinoma through CXCL9 | Backgrounds CXCL9, known as monokine-induced by interferon gamma (MIG), is one of the ligands of chemokine receptor CXCR3 that mediates the infiltration of lymphocytes to focal sites and suppresses tumor growth. Natural killer (NK) cells are lymphocytes belonging to the innate immunity, which can directly kill cancer cells. In addition, they have immunoregulatory activities by secreting multiple cytokines and chemokines. Objective In the present study, we explored the role of CXCL9 in hepatocellular carcinoma (HCC) cell lines cocultured with NK-92. Two HCC cell lines, SK-Hep1 and Hep3B, were cocultured with NK-92. The cytotoxic effect of NK-92 against HCC was analyzed by CytoTox96 assay, and CXCL9 expression was measured using Human Cytokine Array, ELISA and RT q-PCR. Also, the expressions of CXCR3A and CXCR3B were analyzed by western blot. Blocking CXCL9 in Hep3B was performed using CXCL9 shRNA and recombinant human CXCL9 was used to examine the direct role of CXCL9 in NK-92. Results The cytotoxicity of NK-92 was greater against Hep3B than against SK-Hep1, and the mRNA and protein expressions of CXCL9 were significantly higher in Hep3B when cocultured with NK-92. CXCR3B is significantly upregulated compared with CXCR3A in Hep3B and is positively affected by NK-92 coculture. CXCL9 blockade reduced the cytotoxicity of NK-92 against Hep3B. In addition, Recombinant human CXCL9 induced NK-92 chemotaxis along with increased CXCR3, PI3K (p110 gamma), and PLC-beta 3 expression and significantly increased the expressions of T-bet and STAT1, which are associated with NK cell activation. Conclusion These findings suggest that CXCL9 can directly induce NK cells to be recruited to HCC and activate NK cytotoxicity against HCC. | Cho, Yoo Jin; Lee, Hwan Hee; Kang, Hyojeung; Cho, Hyosun | Duksung Womens Univ, Coll Pharm, Seoul 132714, South Korea; Duksung Womens Univ, Duksung Innovat Drug Ctr, Seoul 132714, South Korea; Kyungpook Natl Univ, Coll Pharm, Vessel Organ Interact Res Ctr, Canc Res Inst,VOICE MRC, Daegu 702701, South Korea | 57203930690; 56271051000; 8979751700; 55572361200 | hyosun1102@duksung.ac.kr; | MOLECULAR & CELLULAR TOXICOLOGY | MOL CELL TOXICOL | 1738-642X | 2092-8467 | 18 | 3 | SCIE | TOXICOLOGY | 2022 | 1.7 | 93.1 | 0.55 | 2025-06-25 | 4 | 4 | HCC; Hep3B; NK-92; CXCL9 | PHOSPHOLIPASE C-BETA; LIVER-CANCER CELL; NK CELLS; MICROENVIRONMENT; METASTASIS; ACTIVATION; CHEMOKINES; RELEVANCE; CYTOKINE; TARGET | CXCL9; HCC; Hep3B; NK-92 | chemokine receptor CXCR3; CXCL9 chemokine; cxcr3a protein; cxcr3b protein; messenger RNA; phosphatidylinositol 3 kinase; protein; short hairpin RNA; STAT1 protein; transcription factor T bet; unclassified drug; antineoplastic activity; Article; chemotaxis; coculture; comparative study; controlled study; cytotoxicity; enzyme linked immunosorbent assay; Hep 3B2.1-7 cell line; human; human cell; liver cell carcinoma; lymphocyte activation; natural killer cell; NK-92 cell line; protein expression; protein secretion; real time polymerase chain reaction; signal transduction; SK-HEP-1 cell line; supernatant; upregulation; Western blotting | English | 2022 | 2022-07 | 10.1007/s13273-021-00215-9 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Generation and characterization of cynomolgus monkey kidney fibroblasts (cmKF)-derived induced pluripotent stem cells (cmKF-iPS-C5) | Cynomolgus monkeys, a non-human primate species, are genetically and physiologically similar to humans; hence, they have been employed as an ideal devel-opmental and biomedical model. Non-human primate animals and their induced pluripotent stem cell (iPSC) derivatives have been used as a research tool to investigate autologous regenerative medicine. Here, we reprogrammed cynomolgus monkey kidney fibroblasts (cmKFs) as a control for animal iPSCs and to study autologous transplant. The resulting cmKF-iPSCs, which displayed canonical characteristics of PSCs, could be used as a unique model for autologous cell-based therapy. | Zhen, Xing; Kang, Woojoo; Park, Sang-Je; Choe, Se-Hee; Hong, Seok-Ho; Lee, Dong-Seok; Lee, Jong-Hee | Natl Primate Res Ctr NPRC, Korea Res Inst Biosci & Biotechnol KRIBB, Cheongju, South Korea; Kyungpook Natl Univ, Grad Sch, Dept Nanosci & Nanotechnol, Daegu, South Korea; Kangwon Natl Univ, Sch Med, Dept Internal Med, Chunchon, South Korea; Univ Sci & Technol UST, KRIBB Sch Biosci, Dept Funct Genom, Daejeon, South Korea; Kyungpook Natl Univ, Sch Life Sci, KNU Creat Biores Grp BK21 4, Daegu, South Korea | 57221725411; 57844043400; 24348800900; 56496360900; 34769814700; 57210068061; 57203736066 | lee1@knu.ac.kr;jonglee@kribb.re.kr; | STEM CELL RESEARCH | STEM CELL RES | 1873-5061 | 1876-7753 | 64 | SCIE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY;CELL & TISSUE ENGINEERING;CELL BIOLOGY | 2022 | 1.2 | 93.4 | 0.2 | 2025-06-25 | 2 | 2 | Animals; Cell Differentiation; Fibroblasts; Induced Pluripotent Stem Cells; Kidney; Macaca fascicularis; animal cell; animal experiment; animal model; article; cell therapy; controlled study; fibroblast; Haplorhini; induced pluripotent stem cell; kidney; nonhuman; regenerative medicine; transplantation; animal; cell differentiation; fibroblast; kidney; Macaca fascicularis; physiology | English | 2022 | 2022-10 | 10.1016/j.scr.2022.102887 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||||
| ○ | ○ | Article | Generation and characterization of human umbilical cord blood-derived induced pluripotent stem cells (KRIBBi005-A) | Induced pluripotent stem cells (iPSCs) hold great promise as a potential source for regenerative medicine. Umbilical cord blood (UCB) cells possess a high level of stem cells, exhibit less immune rejection, and have fewer DNA mutations and, thus, are an easily accessible and valuable cell source for iPSC generation for basic research and clinical applications. Here, we reprogrammed CD34(+)-UCB cells with the group O/D-negative (RhD-) blood type as a universal source for red blood cell (RBC) generation. The resulting iPSCs, with features typical of pluripotent stem cells, will further advance the development of various therapeutics, including blood transfusion. | Koh, Hyebin; Zhen, Xing; Kim, Jieun; Ha, Hye-Yeong; Lee, Jong-Hee | Korea Res Inst Biosci & Biotechnol, Natl Primate Res Ctr, Cheongju, South Korea; Korea Res Inst Biosci & Biotechnol, Futurist Anim Resource & Res Ctr FARRC, Cheongju, South Korea; Univ Sci & Technol, KRIBB Sch Biosci, Dept Funct Genom, Daejeon, South Korea; Korea Natl Inst Hlth, Div Intractable Dis Res, Cheongju, South Korea; Kyungpook Natl Univ, Grad Sch, Dept Nanosci & Nanotechnol, Daegu 41566, South Korea; Catholic Univ Korea, Coll Med, Dept Med Life Sci, Seoul, South Korea; Catholic Univ Korea, Coll Med, Dept Biomed & Hlth Sci, Seoul, South Korea | 57199507216; 57221725411; 57221729863; 54888945600; 57203736066 | jonglee@kribb.re.kr; | STEM CELL RESEARCH | STEM CELL RES | 1873-5061 | 1876-7753 | 60 | SCIE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY;CELL & TISSUE ENGINEERING;CELL BIOLOGY | 2022 | 1.2 | 93.4 | 0.1 | 2025-06-25 | 1 | 1 | Antigens, CD34; Fetal Blood; Humans; Induced Pluripotent Stem Cells; Pluripotent Stem Cells; Regenerative Medicine; CD34 antigen; complementary DNA; erythropoietin; genomic DNA; glyceraldehyde 3 phosphate dehydrogenase; hepatocyte nuclear factor 3beta; nestin; octamer transcription factor 4; podocalyxin; protein t box transcription factor t; rhesus D antibody; stage specific embryo antigen 4; T box transcription factor; transcription factor NANOG; transcription factor PAX6; transcription factor Sox17; transcription factor Sox2; unclassified drug; CD34 antigen; agar gel electrophoresis; Article; blood group O; blood transfusion; cell culture; cell differentiation; cell line; cell reprogramming technique; cell therapy; chromosome analysis; clinical article; controlled study; DNA isolation; ectoderm; embryonic stem cell; endoderm; erythroblast; erythrocyte; erythroid cell; female; flow cytometry; fluorescence activated cell sorting; gene deletion; genotyping; human; human cell; immunocytochemistry; induced pluripotent stem cell; karyotype 46,XX; karyotyping; mesoderm; nuclear reprogramming; pluripotent stem cell line; polymerase chain reaction; real time polymerase chain reaction; RNA extraction; short tandem repeat; umbilical cord blood cell; viral clearance; fetus blood; metabolism; pluripotent stem cell; regenerative medicine | English | 2022 | 2022-04 | 10.1016/j.scr.2022.102674 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||||
| ○ | ○ | Article | Generation of induced pluripotent stem cells (cmESF-iPS-C5) derived from cynomolgus monkey ear skin fibroblasts (cmESF) | Cynomolgus monkeys, due to their close anatomical, genetic and physiological similarity to humans, have been employed as a popular laboratory non-human primate model over rodents. Primate animal induced pluripotent stem cell (iPSC) have been used to aid on the investigation of autologous regenerative therapies. Here, we reprogrammed cynomolgus monkey ear skin fibroblasts (cmESFs) into iPSCs as a starting material for autologous based study. The resulting cmESFiPSCs with canonical features of PSCs will advance the development of autologous transplantation. | Zhen, Xing; Park, Sang-Je; Choe, Se-Hee; Lee, Dong-Seok; Lee, Jong-Hee | Korea Res Inst Biosci & Biotechnol KRIBB, Natl Primate Res Ctr NPRC, Cheongju, South Korea; Kyungpook Natl Univ, Grad Sch, Dept Nanosci & Nanotechnol, Daegu, South Korea; Univ Sci & Technol UST, KRIBB Sch Biosci, Dept Funct Genom, Daejeon, South Korea; Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat BioRes Grp, Daegu, South Korea | 57221725411; 24348800900; 56496360900; 57210068061; 57203736066 | lee1@knu.ac.kr;jonglee@kribb.re.kr; | STEM CELL RESEARCH | STEM CELL RES | 1873-5061 | 1876-7753 | 65 | SCIE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY;CELL & TISSUE ENGINEERING;CELL BIOLOGY | 2022 | 1.2 | 93.4 | 0.2 | 2025-06-25 | 2 | 2 | Animals; Induced Pluripotent Stem Cells; Macaca fascicularis; animal cell; animal experiment; animal model; article; autotransplantation; ear; Haplorhini; induced pluripotent stem cell; nonhuman; primate model; rodent; skin fibroblast; animal; Macaca fascicularis | English | 2022 | 2022-12 | 10.1016/j.scr.2022.102977 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||||
| ○ | ○ | Article | Hair Growth-Promoting Activity of Citron Seed Oil: Induction of Premature Telogen-To-Anagen Transition of Hair Follicle in C57BL/6 Mouse Models | Citron (Citrus junos Sieb. Ex Tanaka), a citrus fruit native to Korea, Japan, and China, has been commonly used as a raw material for beverages and herbal medicines. Citron seeds, the by-product of processing industry, contain many bioactive compounds that exhibit several biological properties, such as antioxidative, anti-inflammatory, and antiobesity. However, potential of citron seed oil for hair growth promotion remains unexplored. In the present study, we investigated the hair growth-promoting effect of citron seed oil and its underlying mechanism(s) in a C57BL/6 mouse model. The results show that citron seed oil effectively promotes hair regrowth by early induction of telogen-to-anagen transition and by increasing hair follicle density and hair bulb diameter as well as skin thickness. Citron seed oil treatment increased 6-catenin, lymphoid enhancer binding factor 1, sonic hedgehog, cyclin D1 and cyclin E expressions, and alkaline phosphatase activity, compared to the vehicle-treated control mice. Topical administration of citron seed oil upregulated expression of antiapoptotic Bcl-2 protein but did not alter protein level for proapoptotic Bax in mouse skin tissues. Furthermore, insulin-like growth factor 1 and vascular endothelial growth factor were also induced by citron seed oil treatment. These findings suggest the potential of citron seed oil in the prevention and/or treatment of hair loss by inducing hair cycling and regeneration. | Van-Long Truong; Jeong, Woo-Sik | Kyungpook Natl Univ, Coll Agr & Life Sci, Sch Food Sci Biotechnol, Food & Bioind Res Inst, Daegu 41566, South Korea | Jeong, Woo-Sik/AAN-6885-2020 | 55925363400; 10440750200 | wsjeong@knu.ac.kr; | CURRENT TOPICS IN NUTRACEUTICAL RESEARCH | CURR TOP NUTRACEUT R | 1540-7535 | 2641-452X | 20 | 1 | SCIE | NUTRITION & DIETETICS;PHARMACOLOGY & PHARMACY | 2022 | 0.5 | 93.7 | 0 | 2025-06-25 | 0 | 0 | Alopecia; Citron seed oil; Hair follicles; Sonic hedgehog pathway; Wnt; 6-catenin pathway | DERMAL PAPILLA CELLS; BETA-CATENIN; TOPICAL APPLICATION; FACTOR-I; APOPTOSIS; CYCLE; DIFFERENTIATION; PROLIFERATION; MORPHOGENESIS; EXPRESSION | Alopecia; Citron seed oil; Hair follicles; Sonic hedgehog pathway; Wnt/β-catenin pathway | alkaline phosphatase; beta catenin; citron seed oil; cyclin D1; cyclin E; dermatological agent; lymphoid enhancer factor 1; protein Bax; protein bcl 2; somatomedin C; sonic hedgehog protein; unclassified drug; vasculotropin; vegetable oil; Wnt protein; animal experiment; animal model; animal tissue; apoptosis; Article; citron; controlled study; gene expression; hair follicle; hair growth; hair loss; hair root; hedgehog signaling; male; mouse; nonhuman; plant seed; protein expression; skinfold thickness; upregulation | English | 2022 | 2022-02 | 10.37290/ctnr2641-452x.20:28-36 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | DEVELOPMENT OF A THREE-DIMENSIONAL-PRINTED HEART MODEL REPLICATING THE ELASTICITY, TEAR RESISTANCE, AND HARDNESS OF PIG HEART USING AGILUS AND TANGO | This study proposes a manufacturing method for reproducing some physical properties of the heart by comparing the elasticity, tear resistance, and hardness of a pig heart and three-dimensional printing materials, Agilus and Tango. A Digital Force Gauge was used to analyze elastic modulus and tear resistance, whereas a Shore A hardness meter was used to measure hardness. Agilus and Tango had 10 and 5 times higher elasticity, respectively, 2 and 4 times higher tear resistance, and a higher Shore A hardness than the pig heart. In summary, the pig heart had a more similar elasticity and Shore A hardness than the Tango sample, whereas more tear resistance was similar to the Agilus sample. Therefore, we proposed elasticity and tear resistance equations that can be used to build a heart model and a conversion table for heart fabrication at various thicknesses. | Park, Chun-Kyu; Kim, Junghun | Kyungpook Natl Univ, Dept Biomed Engn, Daegu, South Korea; Kyungpook Natl Univ Hosp, Biomed Res Inst, Daegu, South Korea | 57222736257; 58567949800 | bck0910@naver.com;fainal2@naver.com; | JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY | J MECH MED BIOL | 0219-5194 | 1793-6810 | 22 | 03 | SCIE | BIOPHYSICS;ENGINEERING, BIOMEDICAL | 2022 | 0.8 | 95.0 | 0.24 | 2025-06-25 | 3 | 3 | Pig heart; Agilus; Tango; elastic force; tear resistance; Shore A hardness | MEDICAL-EDUCATION; 3D; TECHNOLOGY; SIMULATION | Agilus; elastic force; Pig heart; Shore A hardness; Tango; tear resistance | 3D printers; Elasticity; Hardness; Mammals; Agili; Elastic force; Heart model; Manufacturing methods; Pig heart; Printing materials; Shore A hardness; Tango; Tear resistance; Three-dimensional-printing; Heart | English | 2022 | 2022-04 | 10.1142/s0219519422400073 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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