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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Comparison of Prognostic Value Between Stimulated and Nonstimulated Thyroglobulins in Differentiated Thyroid Cancer: A Retrospective Study | PurposeThe growing incidence of differentiated thyroid cancer (DTC) demands dependable prognostic factors to guide follow-up and treatment plans. This study investigated the prognostic value of response to therapy (RTT) assessment using TSH stimulated-thyroglobulin (sti-Tg) and nonstimulated-thyroglobulin (nonsti-Tg) and evaluates whether RTT using nonsti-Tg (nonstiRTT) can replace RTT using sti-Tg (stiRTT) in clinical practice to improve patients' quality of life during assessment.MethodsWe enrolled 419 DTC patients who underwent total thyroidectomy, radioactive iodine (RAI) therapy, and Tg assessment. Patients with structural incomplete responses were excluded. Initial RTT assessments based on the 2015 American Thyroid Association guidelines (excellent response; ER, indeterminate response, biochemical incomplete response) were performed 6-24 months after RAI therapy. The second RTT assessments were performed 6-24 months after the first assessment. Statistical analysis for recurrence-free survival (RFS) was done with the log-rank test for stiRTT and nonstiRTT.ResultsAlthough initial stiRTT and nonstiRTT were significant predictors for RFS (p < 0.0001), stiRTT provided better RFS prediction than nonstiRTT. The RFS analysis of the second RTT assessment demonstrated statistical significance only for stiRTT (p < 0.0001). In 116 patients classified as ER on initial stiRTT, there was no RFS difference between patients classified as ER on either second stiRTT or nonstiRTT.ConclusionThe prognostic power of stiRTT surpasses that of nonstiRTT in both the initial and second RTT assessment. Nevertheless, among patients classified as ER on initial stiRTT, a second stiRTT may not be required for those classified as ER on the second nonstiRTT. | Son, Junik; Hong, Chae Moon; Kim, Do-Hoon; Jeong, Shin Young; Lee, Sang-Woo; Lee, Jaetae; Ahn, Byeong-Cheol | Kyungpook Natl Univ Hosp, Dept Nucl Med, 130 Dongdeok Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Nucl Med, Daegu, South Korea; Kyungpook Natl Univ, Dept Nucl Med, Chilgok Hosp, Daegu, South Korea | ; lee, sangwoo/KUD-1906-2024; Son, Junik/GVU-0832-2022 | 57408265500; 37050876700; 55624468392; 36164032500; 57196249819; 7601451907; 7202791511 | dimiaru_jun@outlook.kr;shahking@hanmail.net;k8016851@gmail.com;syjeong@knu.ac.kr;swleenm@knu.ac.kr;jaetae@knu.ac.kr;abc2000@knu.ac.kr; | NUCLEAR MEDICINE AND MOLECULAR IMAGING | NUCL MED MOLEC IMAG | 1869-3474 | 1869-3482 | 57 | 6 | ESCI | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | 2023 | 1.3 | 67.9 | 0 | 2025-06-25 | 0 | 0 | Response to therapy; Thyroid cancer; Thyroglobulin; Stimulated Tg; Nonstimulated Tg | DELAYED RISK STRATIFICATION; SERUM THYROGLOBULIN | Nonstimulated Tg; Response to therapy; Stimulated Tg; Thyroglobulin; Thyroid cancer | fluorodeoxyglucose f 18; iodine 131; levothyroxine; liothyronine sodium; nonstimulated thyroglobulin; stimulated thyroglobulin; thyroglobulin; thyroid hormone; unclassified drug; adult; Article; biochemical incomplete response; cancer prognosis; cancer radiotherapy; clinical practice; computer assisted tomography; dietary pattern; differentiated thyroid cancer; excellent response; female; follow up; general pathological parameters; hormone substitution; human; indeterminate response; low iodine diet; male; neck dissection; positron emission tomography; prognostic value; quality of life; radioactive iodine therapy; radioimmunoassay; recurrence free survival; retrospective study; thyroid hormone replacement therapy; total thyroidectomy; treatment response | English | 2023 | 2023-12 | 10.1007/s13139-023-00811-8 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Second Primary Malignancy After Radioiodine Therapy in Thyroid Cancer Patient: A Nationwide Study | ObjectiveThis study aimed to investigate the risk of second primary malignancy after radioiodine (RAI) therapy in patients with thyroid cancer, using the National Health Insurance Service (NHIS) database.MethodsWe extracted data from the NHIS database of South Korea, which covers the entire population of the nation. Risk of second primary malignancy in the thyroid cancer patients who received RAI therapy were compared with the thyroid cancer patients who received surgery only.ResultsBetween January 1, 2004, and December 31, 2018, we identified 363,155 patients who underwent thyroid surgery due to thyroid cancer for analysis. The surgery only cohort was 215,481, and the RAI cohort was 147,674 patients. A total of 19,385 patients developed second primary malignancy (solid cancer, 18,285; hematologic cancer, 1,100). There was no significant increase in the risk of second primary malignancy in patients who received a total cumulative dose of 100 mCi or less (hazard ratio [HR], 1.013; 95% confidence interval [CI], 0.979-1.049). However, a statistically significant increase in the risk of second primary malignancy was observed in patients who received 101-200 mCi (HR, 1.214; 95% CI, 1.167-1.264), 201-300 mCi (HR, 1.422; 95% CI, 1.258-1.607), and > 300 mCi (HR, 1.693; 95% CI, 1.545-1.854).ConclusionTotal cumulative doses of 100 mCi or less of RAI can be safely administered without concerns about second primary malignancy. However, the risk of second primary malignancy increases in a dose-dependent manner, and the risk-benefit needs to be considered for doses over 100 mCi of RAI therapy. | Hong, Chae Moon; Son, Junik; Hyun, Min Kyung; Lee, Jang Won; Lee, Jaetae | Kyungpook Natl Univ, Sch Med, Dept Nucl Med, 130 Dongdeok Ro, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Dept Nucl Med, Daegu, South Korea; Dongguk Univ, Coll Korean Med, Dept Prevent Med, Gyeongju, South Korea | ; Lee, Jaetae/ABF-3980-2020 | 37050876700; 57408265500; 57211741495; 57221623476; 7601451907 | jaetae@knu.ac.kr; | NUCLEAR MEDICINE AND MOLECULAR IMAGING | NUCL MED MOLEC IMAG | 1869-3474 | 1869-3482 | 57 | 6 | ESCI | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | 2023 | 1.3 | 67.9 | 0.43 | 2025-06-25 | 3 | 3 | Thyroid cancer; Radioiodine therapy; Second primary malignancy; Radiation | RADIOACTIVE IODINE THERAPY; ATOMIC-BOMB SURVIVORS; BREAST-CANCER; RISK; LEUKEMIA | Radiation; Radioiodine therapy; Second primary malignancy; Thyroid cancer | radioactive iodine; adult; Article; bladder cancer; cancer patient; external beam radiotherapy; female; follow up; hematologic malignancy; human; incidence; major clinical study; male; middle aged; national health insurance; non-Hodgkin lymphoma; prostate cancer; second primary neoplasm; solid malignant neoplasm; thyroid cancer; thyroid surgery; thyroidectomy | English | 2023 | 2023-12 | 10.1007/s13139-023-00818-1 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Changes in Lactate-related Fecal Microbiome in Hyperlactatemia Diabetic Dogs | Background/Aim: The correlation between the intestinal microbiome and endocrine disorders has recently been drawing attention as an important key for determining their pathology and clinical assessment. In this study, we evaluated the microbiome of dogs with insulin-dependent diabetes mellitus (IDDM) with respect to blood lactate. Materials and Methods: Fecal samples were obtained from 17 subjects and real-time quantitative polymerase chain reaction determinations were performed to quantify the gene expression levels of lactate-producing and dysbiosis index -related bacteria. Results: Expression levels of the lactate -producing bacteria Lactobacillus spp., Enterococcus spp., and Bifidobacterium spp., were confirmed in patients with high concentrations of lactate in the blood. The abundance of Enterococcus and Bifidobacterium was higher in diabetic dogs compared to that of non-diabetic dogs. When blood lactate concentrations were high, the abundance of Bifidobacterium also increased. Conclusion: Blood lactate levels influence the gut microbiome in dogs with IDDM. This study will help understand the gut microbiota in the context of diabetes in human and veterinary medicine. | Kim, Ji-Hyeon; An, Ju-Hyun; Lee, Jeong-Hwa; Park, Su-Min; Lim, Ga-Hyun; Oh, Ye-In; Seo, Kyeong Won; Youn, Hwa-Young | Seoul Natl Univ, Coll Vet Med, Dept Vet Clin Sci, Lab Vet Internal Med, Seoul 08826, South Korea; Kangwon Natl Univ, Coll Vet Med, Dept Vet Emergency & Crit Care Med, Chuncheon Si, South Korea; Kangwon Natl Univ, Coll Vet Med, Inst Vet Sci, Chuncheon Si, South Korea; Kyungpook Natl Univ, Coll Vet Med, Dept Vet Internal Med, Daegu, South Korea | Lee, Jeong-hwa/KIK-0962-2024 | 57865548100; 57206839650; 57221404340; 57211909684; 58132315300; 36466903200; 8833507700; 7102027331 | hyyoun@snu.ac.kr; | IN VIVO | IN VIVO | 0258-851X | 1791-7549 | 37 | 2 | SCIE | MEDICINE, RESEARCH & EXPERIMENTAL | 2023 | 1.8 | 68.0 | 0 | 2025-06-25 | 1 | 0 | Dog; dysbiosis; insulin-dependent diabetes mellitus; microbiota; lactate | Dog; dysbiosis; insulin-dependent diabetes mellitus; lactate; microbiota | Animals; Diabetes Mellitus, Type 1; Dogs; Gastrointestinal Microbiome; Humans; Hyperlactatemia; Lactic Acid; Microbiota; fructosamine; glucose; hemoglobin A1c; ketone; lactic acid; lactic acid; animal experiment; animal model; Article; Bifidobacterium; blood gas analysis; controlled study; dog; dog breed; dysbiosis; Enterococcus; feces; feces microflora; female; fructosamine blood level; gene expression; gene expression level; glucose blood level; hyperlactatemia; insulin dependent diabetes mellitus; intestine flora; lactate blood level; Lactobacillus; male; microbiome; nonhuman; real time polymerase chain reaction; venous blood; animal; dog; human; intestine flora; microflora | English | 2023 | 2023 (MAR-APR) | 10.21873/invivo.13130 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Free Vertical Latissimus Dorsi Flap for Tongue Reconstruction After Total Glossectomy | Background/Aim: The tongue is an important anatomical structure, playing an significant role in natural speech, swallowing, and sense of taste. Immediate reconstruction using autologous tissue must be performed following glossectomy for tongue cancer to improve patient quality of life. This study aimed to demonstrate the usefulness of a surgical technique using the free vertical latissimus dorsi flap (FvLDF) for tongue reconstructions using autologous tissue. Patients and Methods: Among patients who underwent total glossectomy for tongue cancer from November 2014 to February 2023, we selected 10 patients who underwent immediate tongue reconstruction with a radial free forearm flap (RFFF) or free anterolateral thigh flap and four patients who underwent FvLDF. The patients were compared regarding postoperative function (width of oropharyngeal space in computed tomography, language-speech evaluation), aesthetic results, and features. Results: All four patients who underwent FvLDF showed successful flap survival, with no severe complications. Because vertical incision was made during flap harvest with primary closure possible with the mid-axillary line, donor morbidity was significantly lower in patients who underwent reconstruction with FvLDF than in those who underwent reconstruction with RFFF, and good aesthetic results were obtained. In comparing the oropharyngeal space of patients on neck CT preoperatively and postoperatively, the width increase rate of patients who underwent reconstruction with FvLDF was significantly smaller. FvLDF patients demonstrated good speech and swallowing functions. Conclusion: Considering the advantages of reconstruction with FvLDF in terms of features and aesthetic results, this surgical technique may be a reliable alternative technique for tongue defects after glossectomy. | Lee, Giljoon; Chang, Yong June; Park, Jongmoo; Ryu, Jeong Yeop; Choi, Kang Young; Yang, Jung Dug; Chung, Ho Yun; Cho, Byung Chae; Kang, Byungju; Lee, Jeeyeon; Lee, Joon Seok | Kyungpook Natl Univ, Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Plast & Reconstruct Surg, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Radiat Oncol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Surg, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Plast & Reconstruct Surg, Chilgok Hosp, 807 Hoguk Ro, Daegu 41404, South Korea | Yang, Jung/R-7806-2019; Ryu, Jeong Yeop/GLQ-9419-2022; Lee, Jong-Mok/KVY-9550-2024; LEE, JIN/Q-3108-2018 | 57193082568; 57949685900; 56180048900; 56366349400; 57203745682; 55171704700; 7404007181; 55662871100; 57803481700; 37079213100; 56496041000 | leejspo@knu.ac.kr; | IN VIVO | IN VIVO | 0258-851X | 1791-7549 | 37 | 6 | SCIE | MEDICINE, RESEARCH & EXPERIMENTAL | 2023 | 1.8 | 68.0 | 0.42 | 2025-06-25 | 3 | 3 | Free vertical latissimus dorsi flap; glossectomy; tongue reconstruction; radial free forearm flap; tongue cancer | HEAD | Free vertical latissimus dorsi flap; glossectomy; radial free forearm flap; tongue cancer; tongue reconstruction | Free Tissue Flaps; Glossectomy; Humans; Quality of Life; Superficial Back Muscles; Tongue; Tongue Neoplasms; adrenalin plus lidocaine; antineoplastic agent; adenoid cystic carcinoma; adjuvant radiotherapy; adult; anterolateral thigh flap; Article; autograft; cancer chemotherapy; cancer patient; cancer surgery; cervical spine radiography; clinical article; computed tomographic angiography; controlled study; donor; donor site; female; free tissue graft; free vertical latissimus dorsi flap; human; incision; latissimus dorsi flap; male; middle aged; oropharynx; postoperative period; preoperative evaluation; radial forearm flap; retrospective study; speech; surgical technique; survival; swallowing; tongue cancer; tongue carcinoma; total glossectomy; back muscle; free tissue graft; glossectomy; procedures; quality of life; tongue; tongue tumor | English | 2023 | 2023 (NOV-DEC) | 10.21873/invivo.13381 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Preoperative cardiac troponin I as a predictor of postoperative cardiac events in patients with end stage renal disease undergoing non-cardiac surgery | We investigated if elevated cardiac troponin I (cTnI) serum levels before non-cardiac surgery were predictors of postoperative cardiac events in patients with end stage renal disease (ESRD) undergoing dialysis. In total, 703 consecutive patients with ESRD undergoing dialysis who underwent non-cardiac surgery were enrolled. Preoperative cTnI serum levels were measured at least once in all patients. The primary endpoint was defined as a composite of cardiac death, myocardial infarction (MI), and pulmonary edema during hospitalization or within 30 days after surgery in patients with a hospitalization longer than 30 days after surgery. Postoperative cardiac events occurred in 48 (6.8%) out of 703 patients (cardiac death 1, MI 18, and pulmonary edema 33). Diabetes mellitus (DM), previous ischemic heart disease, and congestive heart failure were more common in patients with postoperative cardiac events. Peak cTnI serum levels were higher in patients with postoperative cardiac event (180 +/- 420 ng/L vs. 80 +/- 190 ng/L, p = 0.008), and also elevated peak cTnI levels > 45 ng/L were more common in patients with postoperative cardiac events (66.8% vs. 30.5%, p = 45 ng/L (OR 3.167, 95% CI 1.557-6.444, p = 0.001) were independent predictors for the primary outcome of cardiac death/MI/pulmonary edema. Moreover, cTnI levels >= 45 ng/L had an incremental prognostic value to the revised cardiac risk index (RCRI) (Chi-square = 23, p < 0.001), and to the combined RCRI and left ventricular ejection fraction (Chi-square = 12, p = 0.001). Elevated preoperative cTnI levels are predictors of postoperative cardiac events including cardiac death, MI, and pulmonary edema in patients with ESRD undergoing non-cardiac surgery. | Park, Bo Eun; Bae, Myung Hwan; Park, Yoon Jung; Kim, Hong Nyun; Kim, Namkyun; Jang, Se Yong; Lee, Jang Hoon; Yang, Dong Heon; Park, Hun Sik; Cho, Yongkeun; Chae, Shung Chull | Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Div Cardiol, 130 Dongdeok Ro, Daegu 41944, South Korea | Park, Hang-soo/AEH-1640-2022 | 57201131446; 36607356800; 57216539556; 56706769800; 55887032700; 57207977889; 54581258000; 35277423400; 57198844106; 9249593500; 7101962036 | bmh0325@knu.ac.kr; | HEART AND VESSELS | HEART VESSELS | 0910-8327 | 1615-2573 | 38 | 2 | SCIE | CARDIAC & CARDIOVASCULAR SYSTEMS;PERIPHERAL VASCULAR DISEASE | 2023 | 1.4 | 68.2 | 0.74 | 2025-06-25 | 6 | 4 | Cardiac troponin I; End stage renal disease; Surgery; Postoperative complications; Myocardial infarction; Risk assessment | GLOMERULAR-FILTRATION-RATE; CARDIOVASCULAR EVENTS; RISK STRATIFICATION; MYOCARDIAL INJURY; ALL-CAUSE; MORTALITY; INDEX; METAANALYSIS; ALBUMINURIA; ASSOCIATION | Cardiac troponin I; End stage renal disease; Myocardial infarction; Postoperative complications; Risk assessment; Surgery | Biomarkers; Death; Humans; Kidney Failure, Chronic; Myocardial Infarction; Pulmonary Edema; Stroke Volume; Troponin I; Ventricular Function, Left; troponin I; biological marker; troponin I; adult; Article; atrial fibrillation; cardiovascular risk; congestive heart failure; controlled study; diabetes mellitus; end stage renal disease; female; heart death; heart infarction; heart left ventricle ejection fraction; hospitalization; human; ischemic heart disease; lung edema; major clinical study; male; middle aged; multivariate logistic regression analysis; outcome assessment; postoperative complication; predictor variable; preoperative evaluation; preoperative period; prognosis; renal replacement therapy; revised cardiac risk index; risk assessment; surgical risk; trend study; chronic kidney failure; complication; death; heart infarction; heart left ventricle function; heart stroke volume; lung edema | English | 2023 | 2023-02 | 10.1007/s00380-022-02159-z | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | The Effect of Reshoring Policy on the Host and Home Countries | This theoretical study explores how a home country's policies influence where multinational companies choose to produce. The study models subsidy negotiations between firms and both the home and foreign countries, revealing that offering reshoring subsidies might lead to repatriation of the multinational firm. If the host country values job creation's welfare gain from reshoring, a large reshoring subsidy from the home government can be seen as socially acceptable and encourage reshoring. However, if the home governments prioritize job creation less and the foreign government aims to retain the firm, pushing for reshoring may increase costs for the foreign country and reduce its social welfare. | Kwon, Chul-Woo; Hwang, Uk | Kyungpook Natl Univ, Dept Econ, 80 Daehak Ro, Daegu 41566, South Korea | 26023382500; 53866824100 | uh202@knu.ac.kr; | INTERNATIONAL ECONOMIC JOURNAL | INT ECON J | 1016-8737 | 1743-517X | 37 | 4 | ESCI | ECONOMICS | 2023 | 0.9 | 68.6 | 0.3 | 2025-06-25 | 2 | 1 | Multinationals; reshoring; offshoring; subsidy; F21; H25 | MONOPOLISTIC COMPETITION | Multinationals; offshoring; reshoring; subsidy | English | 2023 | 2023-10-02 | 10.1080/10168737.2023.2261005 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Post-collisional sedimentation of the Early Mesozoic Munamdong Formation in South Korea | Post-collisional processes cause uplift and exhumation of the overthickened crust together with the formation of sedimentary basins. To determine the influence of post-collisional processes on sedimentation, we investigated the Early Mesozoic Munamdong Formation of the Yuljeon Basin in the Korean Peninsula, deposited immediately after the orogenic events caused by the collision of the North China Block and South China Block. Facies analysis shows that the Munamdong Formation was deposited in a streamflow-dominated alluvial fan under tropical/subtropical climatic conditions. Vertically, the Munamdong Formation exhibits a fining-upward trend with changes in stacking patterns, from highly amalgamated channel conglomerates to floodplain fines, indicating a progressive increase in the creation of accommodation space exceeding sediment supply. Moreover, the types of gravels in the conglomerate beds and the petrographic characteristics of the sandstones suggest that the sediments were supplied rapidly from nearby Precambrian high-grade metamorphic rocks and Triassic post-collisional plutons. These results indicate the supply of sediment from restricted sources, implying that the drainage basins did not widen even during intermittent quiescence of basin subsidence. We interpret the fining-upward trend and uniform composition of sediments to have resulted from rapid uplift and exhumation of the orogenic crust, together with rapid tectonic subsidence, possibly aided by post-collisional magmatism. This study shows that the Munamdong Formation reflects a close connection between surficial sedimentation and post-collisional tectonic processes. This study will help to fill the gap of understanding between deep crustal processes and post-collision sedimentation with insight into the Early Mesozoic tectonic environment of the East Asian continental margins. | Choi, Younggi; Gihm, Yong Sik | Korea Mine Rehabil & Mineral Resources Corp, Overseas Explorat Team, Wonju 26464, South Korea; Kyungpook Natl Univ, Dept Geol, Daegu, South Korea | 57797282800; 56025805300 | dudrl@komir.or.kr; | GEOLOGICAL JOURNAL | GEOL J | 0072-1050 | 1099-1034 | 58 | 1 | SCIE | GEOSCIENCES, MULTIDISCIPLINARY | 2023 | 1.4 | 68.7 | 0.4 | 2025-06-25 | 3 | 2 | Daedong Supergroup; East Asian continental margin; orogenic exhumation; orogeny; streamflow-dominated alluvial fan | DOMINATED ALLUVIAL-FAN; SOUTHWESTERN GYEONGGI MASSIF; METAMORPHIC CORE COMPLEXES; NEOGENE PRODUCTIVE SERIES; UPPER VALDARNO BASIN; U-PB; TECTONIC EVOLUTION; CONGLOMERATE FORMATION; LITHOSPHERIC MANTLE; CHINA COLLISION | Daedong Supergroup; East Asian continental margin; orogenic exhumation; orogeny; streamflow-dominated alluvial fan | South Korea; alluvial fan; continental margin; exhumation; Mesozoic; orogeny; sedimentation; streamflow | English | 2023 | 2023-01 | 10.1002/gj.4588 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Comprehensive molecular analysis to predict the efficacy of chemotherapy containing bevacizumab in patients with metastatic colorectal cancer | Background: Although bevacizumab is an important treatment for metastatic colorectal cancer (CRC), not all patients with CRC benefit from it; in unselected patient populations, only modest survival benefits have been reported.Methods: We evaluated clinical outcomes in 110 patients using comprehensive molecular characterization to identify biomarkers for a response to bevacizumab-containing treatment. The molecular analysis comprised whole-exome sequencing, ribonucleic acid sequencing, and a methylation array on patient tissues.Results: Genomic and molecular characterization was successfully conducted in 103 patients. Six of 103 CRC samples were hypermutated, and none of the non-hypermutant tumors were microsatellite unstable. Among those 103 patients, 89 had adenocarcinoma (ADC), 15 were diagnosed with mucinous ADC, and six had signet-ring cell carcinoma (SRCC). Consensus molecular subtype (CMS) 2 was unique to ADC. Of the four SRCCs, two were CMS1, one was CMS4, and the other was CMS3. APC mutation status was a significantly enriched factor in responders to bevacizumab treatment. Fibroblast growth factor receptor (FGFR) 1/2 signaling was upregulated in non-responders, whereas cell cycle, transfer ribonucleic acid processing, nucleotide excision repair, and oxidative phosphorylation pathways were enriched in responders. In addition, IGF1 was differentially expressed in non-responders (log2 fold change=-1.43, p=4.11 x 10-5, false discovery rate=0.098), and FLT1 was highly methylated in non-responders (p=7.55 x 10-3). When the molecular pathways were reanalyzed separately according to the backbone chemotherapy (FOLFOX vs. FOLFIRI), the significance of the molecular pathways varied according to the backbone chemotherapy.Conclusions: This study sought a subset of CRC patients with a distinct clinical response to chemotherapy containing bevacizumab. Our results need to be validated in a large group of homogenous patient cohort and examined according to the different chemotherapy backbones to create personalized therapeutic opportunities in CRC. | Lim, Sung Hee; Cho, Hee Jin; Kim, Kyoung-Mee; Lim, Ho Yeong; Kang, Won Ki; Lee, Jeeyun; Park, Young Suk; Kim, Hee Cheol; Kim, Seung Tae | Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Div Hematol Oncol,Dept Med, Seoul 06351, South Korea; Samsung Med Ctr, Precis Med Res Inst, Seoul 06351, South Korea; Kyungpook Natl Univ, Dept Biomed Convergence Sci & Technol, Daegu 41566, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Pathol & Translat Genom, Seoul 06351, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Surg, Seoul 06351, South Korea | Lim, Ho Yeong/KBA-8868-2024; park, youngsuk/AAV-3491-2020 | 55757077600; 55937716400; 56155892100; 36838556200; 7202402198; 55899617000; 57225302903; 57191721129; 8638723100 | hc111.kim@samsung.com;shty1@daum.net; | ONCOLOGY RESEARCH | ONCOL RES | 0965-0407 | 1555-3906 | 31 | 6 | SCIE | ONCOLOGY | 2023 | 2 | 68.8 | 0.91 | 2025-06-25 | 7 | 7 | Bevacizumab; Whole-exome sequencing; Ribonucleic acid sequencing; Methylation array; Colorectal cancer | OXALIPLATIN-BASED CHEMOTHERAPY; VEGF RECEPTOR GENES; 1ST-LINE TREATMENT; APC; EXPRESSION; THERAPY; FOLFIRI/BEVACIZUMAB; CAPECITABINE; POLYMORPHISM; COMBINATION | Bevacizumab; Colorectal cancer; Methylation array; Ribonucleic acid sequencing; Whole-exome sequencing | Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Biomarkers; Colonic Neoplasms; Colorectal Neoplasms; Fluorouracil; Humans; Prognosis; RNA; APC protein; B Raf kinase; bevacizumab; complementary DNA; deoxyuridine; DNA; DNA directed DNA polymerase beta; fbwx7 protein; fibroblast growth factor receptor 1; fibroblast growth factor receptor 2; fluorouracil; folinic acid; genomic DNA; irinotecan; K ras protein; MutL protein homolog 1; oxaliplatin; pole protein; protein p53; ribonuclease H; RNA; Smad4 protein; somatomedin C; transcription factor Sox9; transfer RNA; unclassified drug; vasculotropin A; vasculotropin receptor 1; antineoplastic agent; bevacizumab; biological marker; fluorouracil; RNA; adult; aged; Article; cancer combination chemotherapy; cancer patient; cell cycle; clinical evaluation; clinical outcome; cohort analysis; colloid carcinoma; colon polyposis; colorectal adenocarcinoma; colorectal cancer; controlled study; drug efficacy; false discovery rate; female; gene expression; gene mutation; genomics; human; human tissue; major clinical study; male; metastatic colorectal cancer; microsatellite instability; middle aged; molecular biology; nucleotide excision repair; oxidative phosphorylation; protein phosphorylation; RNA methylation; RNA processing; RNA sequencing; signal transduction; signet ring carcinoma; treatment response; upregulation; whole exome sequencing; adenocarcinoma; colon tumor; colorectal tumor; genetics; pathology; prognosis | English | 2023 | 2023 | 10.32604/or.2023.030374 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Meeting Abstract | IMbrave050: Phase 3 study of adjuvant atezolizumab plus bevacizumab versus active surveillance in patients with hepatocellular carcinoma (HCC) at high risk of disease recurrence following resection or ablation | Trojan, J.; Chow, P.; Chen, M.; Cheng, A-L; Kaseb, A.; Kudo, M.; Lee, H. C.; Yopp, A.; Zhou, J.; Wang, L.; Wen, X.; Heo, J.; Tak, W-Y; Nakamura, S.; Numata, K.; Uguen, T.; Hsieh, D.; Cha, E.; Hack, S. P.; Lian, Q.; Spahn, J.; Wu, C.; Qin, S. | Univ Klinikum Frankfurt, Frankfurt, Germany; Natl Canc Ctr Singapore, Singapur, Singapore; Duke NUS Med Sch, Singapur, Singapore; Sun Yat Sen Univ, Ctr Canc, Guangzhou, Guangdong, Peoples R China; Natl Taiwan Univ, Ctr Canc, Taipei, Taiwan; Natl Taiwan Univ Hosp, Taipei, Taiwan; MD Anderson Canc Ctr, Houston, TX USA; Kindai Univ, Osaka, Japan; Univ Ulsan, Asan Med Ctr, Seoul, South Korea; UT Southwestern Med Ctr, Dallas, TX USA; Fudan Univ, Zhongshan Hosp, Shanghai, Peoples R China; Fudan Univ, Shanghai Canc Ctr, Shanghai, Peoples R China; 1st Hosp Jilin Univ, Jilin, Jilin, Peoples R China; Pusan Natl Univ, Coll Med, Busan, South Korea; Pusan Natl Univ Hosp, Biomed Res Inst, Busan, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Daegu, South Korea; Himeji Red Cross Hosp, Himeji, Hyogo, Japan; Yokohama City Univ, Med Ctr, Yokohama, Kanagawa, Japan; Hosp Pontchaillou, Rennes, France; Genentech Inc, San Francisco, CA USA; Roche Holding Ltd, Shanghai, Peoples R China; Nanjing Univ Chinese Med, Jinling Hosp, Nanjing, Peoples R China | Jeong, Sook-Hyang/J-5642-2012; Trojan, Jörg/C-1616-2009; Kudo, Masatoshi/AAA-9744-2019 | ONCOLOGY RESEARCH AND TREATMENT | ONCOL RES TREAT | 2296-5270 | 2296-5262 | 46 | SCIE | ONCOLOGY | 2023 | 2 | 68.8 | 0 | English | 2023 | 2023-10-03 | 바로가기 | 바로가기 | ||||||||||||||||
| ○ | Article | Explainable artificial intelligence envisioned security mechanism for cyber threat hunting | Cyber threat hunting proactively searches for cyber threats, which are undetected by the traditional defense mechanisms. It scans deep to identify malicious programs (ie, malware) that escape from detection. It is important because sophisticated cyber threats can bypass the cyber security mechanisms. The performance of the cyber threat hunting can be improved through artificial intelligence (AI), especially, explainable AI (XAI), which adds trust component to the cyber threat hunting process. Due to the inclusion of XAI, the security experts get the full explanations of the detected threats as the working of the detection model in XAI is known. Information, like, which one is a threat, how it has been detected, and why it has been detected, can be obtained very easily due to the inclusion of XAI in the cyber threat hunting. Therefore, an XAI-envisioned mechanism for cyber threat hunting has been proposed (in short, XAISM-CTH). The network and threat models of XAISM-CTH are designed and discussed. The conducted security analysis proves the security of XAISM-CTH against various potential attacks. XAISM-CTH also performs better than the other existing schemes. At the end, a practical implementation of XAISM-CTH has been provided to observe its impact on the performance of the system. | Kumar, Pankaj; Wazid, Mohammad; Singh, D. P.; Singh, Jaskaran; Das, Ashok Kumar; Park, Youngho; Rodrigues, Joel J. P. C. | Graph Era Deemed Univ, Dept Comp Sci & Engn, Dehra Dun 248002, India; Int Inst Informat Technol, Ctr Secur Theory & Algorithm Res, Hyderabad, India; Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu, South Korea; China Univ Petr East China, Coll Comp Sci & Technol, Qingdao, Peoples R China; Inst Telecomunicacoes, Covilha, Portugal | ; Das, Ashok Kumar/U-2790-2019; wazid, mohammad/X-4211-2018; WAZID, MOHAMMAD/X-4211-2018; Singh, Devesh/KIC-3651-2024; Singh, Jaskaran/AGX-6621-2022; Rodrigues, Joel/A-8103-2013 | wazidkec2005@gmail.com; | SECURITY AND PRIVACY | SECUR PRIVACY | 2475-6725 | 6 | 6 | ESCI | COMPUTER SCIENCE, INFORMATION SYSTEMS;TELECOMMUNICATIONS | 2023 | 1.5 | 69.0 | 4 | cyber threat hunting; explainable artificial intelligence (XAI); intrusion detection; privacy; security | BOTNET DETECTION | English | 2023 | 2023-11 | 10.1002/spy2.312 | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | ○ | Article | Fusion of monocular height maps for 3D urban scene reconstruction from uncalibrated satellite images | With the increased availability of multi-view satellite images, the number of investigations on 3D urban scene reconstruction from multiple satellite images is also increasing. Conventional Multi-View Stereo (MVS) pipelines require the calibrated pose information of the satellite cameras to determine the epipolar geometry and the 3D structure of the stereo correspondences. In this study, we propose a novel Monocular Height estimation and Fusion (MHF) method for 3D reconstruction from uncalibrated multi-view satellite images. By employing a learned monocular depth network, the proposed method first obtains the height map of each satellite image. Second, all height maps obtained from the multi-view images are fused to a refined height map in each image plane. To fuse the height maps, all maps are affine transformed to a virtual reference coordinate system and the transformed maps are then projected to the image plane of each camera coordinate system. The monocular depth network was trained and evaluated on the Data Fusion Contest 2019 (DFC19) dataset including Jacksonville, FL, and Omaha, NE. We also evaluate the ATL-SN4 dataset covering Atlanta, GA to test on untrained new urban scenes. | Park, Soon-Yong; Son, Chang-Min; Seo, Donguk; Baek, Seung-Hae | Kyungpook Natl Univ, Sch Elect Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, Grad Sch Elect & Elect Engn, Daegu, South Korea; KLA Corp, LS Swift Div, Hwaseong Si, Gyeonggi Prov, South Korea | ; Park, Soon-Yong/HGV-2374-2022 | 7501834063; 57826492700; 58266434300; 48861235500 | sypark@knu.ac.kr; | REMOTE SENSING LETTERS | REMOTE SENS LETT | 2150-704X | 2150-7058 | 14 | 12 | SCIE | IMAGING SCIENCE & PHOTOGRAPHIC TECHNOLOGY;REMOTE SENSING | 2023 | 1.4 | 69.0 | 0 | 2025-06-25 | 0 | 0 | Monocular height map; 3D urban scene reconstruction; Deep learning; Photogrammetry; Uncalibrated satellite image | 3D urban scene reconstruction; Deep learning; Monocular height map; Photogrammetry; Uncalibrated satellite image | Atlanta; Florida [United States]; Georgia; Jacksonville; Nebraska; Omaha; United States; Cameras; Image fusion; Image reconstruction; Satellites; Statistical tests; Stereo image processing; 3d urban scene reconstruction; Deep learning; Height map; Monocular height map; Multi-views; Satellite images; Scene reconstruction; Uncalibrated; Uncalibrated satellite image; Urban scenes; data set; height; machine learning; photogrammetry; satellite imagery; three-dimensional modeling; Deep learning | English | 2023 | 2023-12-02 | 10.1080/2150704x.2023.2283901 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | The effect of social media on social capital and life-satisfaction in the case of college sports | The growing use of social media has resonated with scholars to examine the role of social media in society. Given that sports are an integral part of American society, it is imperative to ask how the use of social media for sports is associated with individuals' lives. In an attempt to answer this question, the current study employs the concept of social identification and social capital as a theoretical framework. Using survey data collected in the domain of college sports, the path analysis demonstrates the interlinked relationships between the use of social media, social capital, identification, and life satisfaction. Particularly, it is noteworthy that the use of social media is positively related to the production of social capital and life satisfaction both directly and indirectly through identification. Theoretical and practical implications are discussed. | Kim, Hyuksoo; Ahn, Jungsun | Kyungpook Natl Univ, Sch Business Adm, Coll Econ & Business Adm, Daegu, South Korea; Hongik Univ, Sch Advertising & Publ Relat, Sejong, South Korea | 57110953000; 56149208100 | hongikajs@gmail.com; | ATLANTIC JOURNAL OF COMMUNICATION | ATL J COMMUN | 1545-6870 | 1545-6889 | 31 | 3 | ESCI | COMMUNICATION | 2023 | 0.7 | 69.1 | 0.24 | 2025-06-25 | 1 | 1 | GROUP IDENTIFICATION; SELF-ESTEEM; TEAM IDENTIFICATION; NETWORK SITES; FACEBOOK USE; IN-GROUP; IDENTITY; FANS; BEHAVIOR; PARTICIPATION | English | 2023 | 2023-05-27 | 10.1080/15456870.2022.2061712 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Review | Effects of Digital Physical Activity Interventions for Breast Cancer Patients and Survivors: A Systematic Review and Meta-Analysis | Objectives: The benefits of physical activity (PA) for breast cancer (BC) patients and survivors are well documented. With the widespread use of the internet and mobile phones, along with the recent coronavirus disease 2019 pandemic, there has been a growing interest in digital health interventions. This study conducted a systematic review and meta-analysis to evaluate the effects of digital PA interventions for BC patients and survivors in improving PA and quality of life (QoL). Methods: We searched eight databases, including PubMed, CINAHL, Embase, Scopus, Web of Science, Cochrane Central Register of Controlled Trials in the Cochrane Library, RISS, and DBpia. Studies were included if they provided digital PA interventions, assessed PA and QoL among BC patients and survivors, and were published from inception to December 31, 2022. Results: In total, 18 studies were identified. The meta-analysis showed significant improvement in the total PA duration (five studies; standardized mean difference [SMD] = 0.71; 95% confidence interval [CI], 0.25-1.18; I-2 = 86.64%), functional capacity (three studies; SMD = 0.38; 95% CI, 0.10-0.66; I-2 = 14.36%), and QoL (nine studies; SMD = 0.45; 95% CI, 0.22-0.69; I-2 = 65.55%). Conclusions: Digital PA interventions for BC patients and survivors may significantly improve PA, functional capacity, and QoL. Future research should focus on the long-term effects of digital PA interventions, using objective outcome measures. | Kang, Hyunwook; Moon, Mikyung | Kangwon Natl Univ, Coll Nursing, Chunchon, South Korea; Kyungpook Natl Univ, Coll Nursing, Daegu, South Korea | 56567050700; 55258257000 | mkmoon@knu.ac.kr; | HEALTHCARE INFORMATICS RESEARCH | HEALTHC INFORM RES | 2093-3681 | 2093-369X | 29 | 4 | ESCI | MEDICAL INFORMATICS | 2023 | 2.3 | 69.3 | 0.28 | 2025-06-25 | 4 | 2 | Breast Neoplasms; Digital Technology; Exercise; Meta-Analysis; Systematic Review | QUALITY-OF-LIFE; EUROPEAN-ORGANIZATION; HEALTH INTERVENTIONS; EXERCISE; THERAPY; QUESTIONNAIRE; RELIABILITY; OUTCOMES; TRIAL | Breast Neoplasms; Digital Technology; Exercise; Meta-Analysis; Systematic Review | English | 2023 | 2023-10 | 10.4258/hir.2023.29.4.352 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Influence of tidal state on air temperature through penetrating sea breeze front in Seoul in summer | We examine the influence of tidal flats on the daily maximum air temperature in Seoul related to the penetration of sea-breeze front (SBF) using meteorological station data of summer over 10 years (2010-2019). The penetration of SBF at Seoul is detected using an objective SBF detection algorithm. 491 (53%) of the 920 days are classified as those with SBF passage on the coast. The SBF arrives in Seoul on 87% of sea breeze days on the coast. The passage time of the SBF in Seoul peaks between 1400 and 1600 LST, while the traveling time of SBF from the coast to Seoul peaks between 3 and 4 h. The cooling effect of sea breeze in Seoul is examined using the sea-breeze cooling capacity. We divide the sea-breeze days in Seoul into three groups in terms of the arrival time of the SBF in Seoul: before 1200 LST, between 1200 and 1500 LST, and after 1500 LST. All three groups show the cooling effect of sea breeze, which is greatest in the group where the SBF arrives before 1200 LST. The relationship between the tidal state and daily maximum temperature in Seoul is examined. Summer days are divided into four groups depending on the tidal state in the morning (0800-1200 LST) and ambient flow direction. The tidal effect on the daily maximum temperature in Seoul is tested at a significant level of 10% using a two-sample t test for onshore and offshore flows. A significant difference (p = 0.086) is observed for offshore flows, showing a higher daily maximum temperature in the low-tide group in the morning (LTM) than in the high-tide group in the morning (HTM). The passage rate of the SBF at Seoul in the LTM is less than that in the HTM for offshore flows. A weaker sea-breeze forcing and longer distance between the water boundary and Seoul in the LTM could prevent the inland penetration of the SBF, increasing the daily maximum temperature in Seoul. | Lee, Young-Hee | Kyungpook Natl Univ, Dept Atmospher Sci, Daegu 41566, South Korea | 56812706200 | young@knu.ac.kr; | METEOROLOGY AND ATMOSPHERIC PHYSICS | METEOROL ATMOS PHYS | 0177-7971 | 1436-5065 | 135 | 3 | SCIE | METEOROLOGY & ATMOSPHERIC SCIENCES | 2023 | 1.9 | 69.5 | 0 | 2025-06-25 | 0 | 0 | URBAN HEAT-ISLAND; INLAND PENETRATION; COMFORT; IMPACT; WAVES; COAST | Seoul [South Korea]; South Korea; air temperature; climate modeling; cooling; regional climate; sea breeze; summer; temperature profile | English | 2023 | 2023-06 | 10.1007/s00703-023-00968-z | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | A Search for Exoplanets around Northern Circumpolar Stars. IX. A Multi-Period Analysis of the M Giant HD 135438 | It is difficult to distinguish the pure signal produced by an orbiting planetary companion around giant stars from other possible sources, such as stellar spots, pulsations, or certain activities. Since 2003, we have obtained radial (RV) data from evolved stars using the high-resolution, fiber-fed Bohyunsan Observatory Echelle Spectrograph (BOES) at the Bohyunsan Optical Astronomy Observatory (BOAO). Here, we report the results of RV variations in the binary star HD 135438. We found two significant periods: 494.98 d with eccentricity of 0.23 and 8494.1 d with eccentricity of 0.83. Considering orbital stability, it is impossible to have two companions in such close orbits with high eccentricity. To determine the nature of the changes in the RV variability, we analyzed indicators of stellar spot and stellar chromospheric activity to find that there are no signals related to the significant period of 494.98 d. However, we calculated the upper limits of rotation period of the rotational velocity and found this to be 478-536 d. One possible interpretation is that this may be closely related to the rotational modulation of an orbital inclination at 67-90 degrees. The other signal corresponding to the period of 8494.1 d is probably associated with a stellar companion orbiting the giant star. A Markov Chain Monte Carlo (MCMC) simulation considering a single companion indicates that HD 135438 system hosts a stellar companion with 0.57+0.017 -0.017 M circle dot with an orbital period of 8498 d. | Lee, Byeong-Cheol; Koo, Jae-Rim; Choi, Yeon-Ho; Bang, Tae-Yang; Lim, Beomdu; Park, Myeong-Gu; Jeong, Gwanghui | Korea Astron & Space Sci Inst, Daejeon 34055, South Korea; Korea Univ Sci & Technol, Daejeon 34113, South Korea; Kongju Natl Univ, Gongju Si 32588, Chungcheongnam, South Korea; Kyungpook Natl Univ, Dept Astron & Atmospher Sci, Daegu 41566, South Korea; Antbridge Inc, Space Sci Res Ctr, Daejeon 34120, South Korea | 8878262900; 15127066700; 57247914500; 57201317966; 36499772800; 7404490321; 56152551500 | bclee@kasi.re.kr; | JOURNAL OF THE KOREAN ASTRONOMICAL SOCIETY | J KOREAN ASTRON SOC | 1225-4614 | 56 | 2 | SCIE | ASTRONOMY & ASTROPHYSICS | 2023 | 1.1 | 69.6 | 0.12 | 2025-06-25 | 1 | 1 | stars; individual; HD 135438-techniques; radial velocities - stars; planetary systems | RADIAL-VELOCITY VARIABILITY; HIPPARCOS-GAIA CATALOG; ATMOSPHERIC PARAMETERS; MAGNETIC ACTIVITY; PLANET; PHOTOMETRY; PRECISION; SYSTEMS; ALPHA | stars: individual: HD 135438; stars: planetary systems; techniques: radial velocities | English | 2023 | 2023-04 | 10.5303/jkas.2023.56.2.277 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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