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| ○ | ○ | Review | Red ginseng (Panax ginseng Meyer) oil: A comprehensive review of extraction technologies, chemical composition, health benefits, molecular mechanisms, and safety | Red ginseng oil (RGO), rather than the conventional aqueous extract of red ginseng, has been receiving much attention due to accumulating evidence of its functional and pharmacological potential. In this review, we describe the key extraction technologies, chemical composition, potential health benefits, and safety of RGO. This review emphasizes the proposed molecular mechanisms by which RGO is involved in various bioactivities. RGO is mainly produced using organic solvents or supercritical fluid extraction, with the choice of method greatly affecting the yield and quality of the end products. RGO contains a high unsaturated fatty acid levels along with considerable amounts of lipophilic components such as phytosterols, tocopherols, and polyacetylenes. The beneficial health properties of RGO include cellular defense, antioxidation, anti-inflammation, anti-apoptosis, chemoprevention, hair growth promotion, and skin health improvement. We propose several molecular mechanisms and signaling pathways that underlie the bioactivity of RGO. In addition, RGO is regarded as safe and nontoxic. Further studies on RGO must focus on a deeper understanding of the underlying molecular mechanisms, composition-functionality relationship, and verification of the bioactivities of RGO in clinical models. This review may provide useful information in the development of RGO-based products in nutraceuticals, functional foods, and functional cosmetics. (c) 2021 The Korean Society of Ginseng. Publishing services by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | Van-Long Truong; Jeong, Woo-Sik | Kyungpook Natl Univ, Coll Agr & Life Sci, Sch Food Sci & Biotechnol, Food & Bioind Res Inst, Daegu 41566, South Korea | Jeong, Woo-Sik/AAN-6885-2020 | 55925363400; 10440750200 | truonglongpro@gmail.com;wsjeong@knu.ac.kr; | JOURNAL OF GINSENG RESEARCH | J GINSENG RES | 1226-8453 | 2093-4947 | 46 | 2 | SCIE | CHEMISTRY, MEDICINAL;INTEGRATIVE & COMPLEMENTARY MEDICINE | 2022 | 6.3 | 5.4 | 1.36 | 2025-06-25 | 22 | 25 | Panax ginseng; Red ginseng oil; Health bene fits; Molecular mechanism; Safety | SUPERCRITICAL-FLUID EXTRACTION; NF-KAPPA-B; CANCER CHEMOPREVENTION; LIQUID-CHROMATOGRAPHY; BETA-SITOSTEROL; WHITE GINSENG; FREE-RADICALS; IN-VIVO; GINSENOSIDES; ANTIOXIDANT | Health benefits; Molecular mechanism; Panax ginseng; Red ginseng oil; Safety | antiinflammatory agent; antineoplastic agent; antioxidant; organic solvent; phytochemical; phytosterol; polyacetylene derivative; red ginseng oil; skin protective agent; tocopherol derivative; unclassified drug; unsaturated fatty acid; vegetable oil; antiapoptotic activity; antiinflammatory activity; antineoplastic activity; antioxidant activity; apoptosis; biological activity; chemical composition; chemoprophylaxis; drug isolation; drug mechanism; drug safety; fatty acid level; ginseng; hair growth; human; lipophilicity; nonhuman; phytochemistry; Review; signal transduction; skin protection; solvent extraction; supercritical fluid extraction | English | 2022 | 2022-03 | 10.1016/j.jgr.2021.12.006 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Restorative effects of Rg3-enriched Korean Red Ginseng and Persicaria tinctoria extract on oxazolone-induced ulcerative colitis in mice | Background: Ulcerative colitis (UC) is the large intestine disease that results in chronic inflammation and ulcers in the colon. Rg3-enriched Korean Red Ginseng extract (Rg3-RGE) is known for its pharmacological activities. Persicaria tinctoria (PT) is also used in the treatment of various inflammatory diseases. The aim of this study is to investigate the attenuating effects of Rg3-RGE with PT on oxazolone (OXA)-induced UC in mice. Methods: A total of six groups of mice including control group, OXA (as model group, 1.5%) group, sulfasalazine (75 mg/kg) group, Rg3-RGE (20 mg/kg) group, PT (300 mg/kg) group, and Rg3-RGE (10 mg/kg) with PT (150 mg/kg) group. Data on the colon length, body weight, disease activity index (DAI), histological changes, nitric oxide (NO) assay, Real-time PCR of inflammatory factors, ELISA of inflammatory factors, Western blot, and flow cytometry analysis were obtained. Results: Overall, the combination treatment of Rg3-RGE and PT significantly improved the colon length and body weight and decreased the DAI in mice compared with the treatment with OXA. Additionally, the histological injury was also reduced by the combination treatment. Moreover, the NO production level and inflammatory mediators and cytokines were significantly downregulated in the Rg3-RGE with the PT group compared with the model group. Also, NLR family pyrin domain containing 3 (NLRP3) inflammasome and nuclear factor kappa B (NF-kappa B) were suppressed in the combination treatment group compared with the OXA group. Furthermore, the number of immune cell subtypes of CD4(+) T-helper cells, CD19(+) B-cells, and CD4(+) and CD25(+) regulatory T-cells (Tregs) was improved in the Rg3-RGE with the PT group compared with the OXA group. Conclusion: Overall, the mixture of Rg3-RGE and PT is an effective therapeutic treatment for UC. (C) 2021 The Korean Society of Ginseng. Publishing services by Elsevier B.V. | Ullah, H. M. Arif; Saba, Evelyn; Lee, Yuan Yee; Hong, Seung-Bok; Hyun, Sun-Hee; Kwak, Yi-Seong; Park, Chae-Kyu; Kim, Sung Dae; Rhee, Man Hee | Kyungpook Natl Univ, Coll Vet Med, Dept Vet Med, Daegu 41566, South Korea; Pir Mehr Ali Shah Arid Agr Univ, Fac Vet & Anim Sci, Dept Vet Biomed Sci, Lahore, Pakistan; Chungbuk Hlth & Sci Univ, Dept Clin Lab Sci, Chungbuk, South Korea; Korean Ginseng Cooperat, R&D Headquarters, Daejeon, South Korea | ; Yuan Yee, Lee/ABH-8956-2022; Ullah, H/AAE-5513-2021; Rhee, Man/O-5705-2016; Saba, Evelyn/JLN-1878-2023 | 57198885380; 56721112000; 57203798815; 9237099500; 57225302366; 36868130200; 55885553100; 55156746000; 57211035357 | rheemh@knu.ac.kr; | JOURNAL OF GINSENG RESEARCH | J GINSENG RES | 1226-8453 | 2093-4947 | 46 | 5 | SCIE | CHEMISTRY, MEDICINAL;INTEGRATIVE & COMPLEMENTARY MEDICINE | 2022 | 6.3 | 5.4 | 1.34 | 2025-06-25 | 10 | 11 | Korean Red Ginseng; Ginsenoside Rg3; Persicaria tinctoria; Inflammation; Colitis | NF-KAPPA-B; INFLAMMATION; SUPPRESSION; MODEL | Colitis; Ginsenoside Rg3; Inflammation; Korean Red Ginseng; Persicaria tinctoria | CD19 antigen; CD3 antigen; CD4 antigen; CD8 antigen; complementary DNA; cryopyrin; cyclooxygenase 2; ginseng extract; ginsenoside Rg 3; glyceraldehyde 3 phosphate dehydrogenase; immunoglobulin enhancer binding protein; inducible nitric oxide synthase; interleukin 1; interleukin 13; interleukin 1beta; interleukin 5; nitric oxide; oxazolone; Persicaria tinctoria extract; plant extract; salazosulfapyridine; tumor necrosis factor; unclassified drug; animal cell; animal experiment; animal model; Article; B lymphocyte; body weight; CD4+ T lymphocyte; colon tissue; comparative study; controlled study; cytokine production; disease activity; down regulation; drug effect; enzyme linked immunosorbent assay; flow cytometry; ginseng; helper cell; histology; histopathology; immunocompetent cell; male; mouse; nonhuman; Persicaria; Persicaria tinctoria; real time polymerase chain reaction; regulatory T lymphocyte; spleen tissue; ulcerative colitis; weight; Western blotting | English | 2022 | 2022-09 | 10.1016/j.jgr.2021.07.001 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Letter | Selenomonas: A marker of asthma severity with the potential therapeutic effect | Kim, Young-Chan; Choi, Sungmi; Sohn, Kyoung-Hee; Bang, Ji-Young; Kim, Yuldam; Jung, Jae-Woo; Kim, Hye-Young; Park, Jaehyun; Kim, Kangjin; Kang, Min-Gyu; Yang, Min-Suk; Kim, Sujeong; Kim, Sae-Hoon; Choi, Jeong-Hee; Park, Hye Jung; Lee, Sang Min; Kim, Sang Heon; Park, Jung-Won; Lee, Jong Myung; Cho, Sang-Heon; Won, Sungho; Yi, Hana; Kang, Hye-Ryun | Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea; Korea Univ, Interdisciplinary Program Precis Publ Hlth, Seoul, South Korea; Kyung Hee Univ Hosp, Dept Internal Med, Seoul, South Korea; Seoul Natl Univ, Coll Med, Dept Translat Med, Seoul, South Korea; Chung Ang Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Seoul Natl Univ, Coll Med, Dept Biomed Sci, Lab Mucosal Immunol, Seoul, South Korea; Seoul Natl Univ, Coll Nat Sci, Interdisciplinary Program Bioinformat, Seoul, South Korea; Seoul Natl Univ, Inst Hlth & Environm, Seoul, South Korea; Chungbuk Natl Univ, Chungbuk Natl Univ Hosp, Coll Med, Dept Internal Med, Cheongju, South Korea; SMG SNU Boramae Med Ctr, Dept Internal Med, Seoul, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Seongnam, South Korea; Hallym Univ, Coll Med, Immunol Res Ctr, Dept Pulmonol & Allergy Allergy & Clin, Chunchon, South Korea; Gangnam Severance Hosp, Dept Internal Med, Seoul, South Korea; Gachon Univ, Gil Med Ctr, Dept Internal Med, Incheon, South Korea; Hanyang Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Yonsei Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Seoul Natl Univ, Coll Med, Med Res Ctr, Inst Allergy & Clin Immunol, Seoul, South Korea; Korea Univ, Sch Biosyst & Biomed Sci, 145 Anam Ro, Seoul 02841, South Korea | ; Kim, Hye/AAF-7609-2020; Park, Jaehyun/LPQ-4712-2024; Sohn, Kyoung-Hee/HNJ-2671-2023; Kim, Sae/AAR-3907-2020; Kim, Ju-Hyoung/N-1450-2019; Jung, Jae-Woo/L-9451-2019; Kim, Kangjin/HKW-5248-2023 | 57190214092; 56856237700; 55901812200; 57299490300; 57299122400; 57189648165; 55676285000; 57196406278; 57189250882; 55908899100; 7404927140; 36666447400; 35198322400; 7501395695; 56734724500; 55913470000; 56590456700; 8591768500; 36123106800; 56582804700; 57207796874; 7202720196; 7404070922 | hanayi@korea.ac.kr;helenmed@snu.ac.kr; | ALLERGY | ALLERGY | 0105-4538 | 1398-9995 | 77 | 1 | SCIE | ALLERGY;IMMUNOLOGY | 2022 | 12.4 | 5.4 | 2.98 | 2025-06-25 | 12 | 12 | MICROBIOME | Asthma; Humans; RNA, Ribosomal, 16S; Selenomonas; interleukin 13; interleukin 5; RNA 16S; Actinomyces; allergy patient; animal experiment; animal model; asthma; Asthma Control Questionnaire; Asthma Control Test; asthmatic state; Atopobium; bacterial microbiome; bronchoalveolar lavage fluid; Campylobacter; clinical feature; colony forming unit; controlled study; disease marker; disease severity; forced expiratory volume; Gemella; Haemophilus; human; inflammatory cell; Leptotrichia; Letter; lung microbiota; major clinical study; microbial diversity; microbial interaction; Neisseria; nonhuman; Peptostreptococcus; Prevotella; respiratory tract allergy; respiratory tract inflammation; Saccharimonas; Selenomonas; sensitization; severe asthma; Streptococcus; Th2 cell; therapy effect; Veillonella; asthma; genetics | English | 2022 | 2022-01 | 10.1111/all.15114 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Sex Difference in the Tolerance of Hepatic Ischemia-reperfusion Injury and Hepatic Estrogen Receptor Expression According to Age and Macrosteatosis in Healthy Living Liver Donors | Background. Hepatic estrogen signaling, which is important in liver injury/recovery, is determined by the level of systemic estrogen and hepatic estrogen receptor. We aimed to evaluate whether females' advantage in the tolerance of hepatic ischemia-reperfusion injury decreases according to the age of 40 y (systemic estrogen decrease) and macrosteatosis (hepatic estrogen receptor decrease). Methods. We included 358 living liver donors (128 female and 230 male individuals). The tolerance of hepatic ischemia-reperfusion injury was determined by the slope of the linear regression line modeling the relationship between the duration of intraoperative hepatic ischemia and the peak postoperative transaminase level. Estrogen receptor content was measured in the biopsied liver samples using immunohistochemistry. Results. In the whole cohort, the regression slope for aspartate transaminase was comparable between female and male individuals (P = 0.940). Within the subgroup of donors aged 40 y (P = 0.867). Within the subgroup of nonmacrosteatotic donors aged 40 y or with macrosteatosis (P = 0.450). Conclusions. The tolerance of hepatic ischemia-reperfusion injury was greater in female individuals than in male individuals only when they were <40 y and without macrosteatosis. The results were in agreement with the hepatic estrogen receptor immunohistochemistry study. | Han, Sangbin; Cho, Junhun; Wi, Wongook; Lee, Kyo Won; Cha, Hyun Hwa; Lee, Sanghoon; Ahn, Joong Hyun; Kim, Seonwoo; Choi, Gyu Sung; Kim, Jong Man; Ha, Sang Yun; Kim, Gaab Soo; Joh, Jae-Won | Sungkyunkwan Univ, Samsung Med Ctr, Dept Anesthesiol & Pain Med, Sch Med, 81 Irwon Ro, Seoul 06351, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Pathol & Translat Genom, Sch Med, 81 Irwon Ro, Seoul 06351, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Surg, Sch Med, 81 Irwon Ro, Seoul 06351, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Dept Obstet & Gynecol, Sch Med, Daegu, South Korea; Samsung Med Ctr, Stat & Data Ctr, Res Inst Future Med, Div Stat, Seoul, South Korea | Kim, Jong/AAH-5295-2020; Wi, Wongook/JCD-4627-2023; Lee, Jeeyun/I-7171-2015; kim, seonwoo/IWE-3812-2023 | 55578196500; 57216677597; 57203992623; 57196252088; 37033517800; 57202883546; 55224100800; 57196231483; 22939899200; 36065224600; 56405966100; 55664740800; 7005275030 | hans5@skku.edu;sangyun.ha@skku.edu;jwjoh@skku.edu; | TRANSPLANTATION | TRANSPLANTATION | 0041-1337 | 1534-6080 | 106 | 2 | SCIE | IMMUNOLOGY;SURGERY;TRANSPLANTATION | 2022 | 6.2 | 5.4 | 0.74 | 2025-06-25 | 6 | 5 | FOLLICLE-STIMULATING-HORMONE; FATTY LIVER; PRINGLES MANEUVER; MENOPAUSAL TRANSITION; GENDER-DIFFERENCES; INFLOW OCCLUSION; FEMALE DONOR; STEATOSIS; DISEASE; MECHANISMS | Aged; Alanine Transaminase; Aspartate Aminotransferases; Estrogens; Female; Healthy Lifestyle; Humans; Liver; Living Donors; Male; Receptors, Estrogen; Reperfusion Injury; Sex Characteristics; alanine aminotransferase; albumin; aspartate aminotransferase; bilirubin; creatinine; estrogen receptor; hemoglobin; alanine aminotransferase; aspartate aminotransferase; estrogen; estrogen receptor; adult; Article; body mass; cohort analysis; comparative study; controlled study; disease duration; female; groups by age; hepatic ischemia reperfusion injury; human; human tissue; immunohistochemistry; incidence; intraoperative period; ischemia time; linear regression analysis; liver biopsy; liver donor; liver transplantation; living donor; macrosteatosis; male; multivariate analysis; operation duration; perioperative monitoring; platelet count; postoperative period; protein expression; retrospective study; sex difference; statistical significance; aged; healthy lifestyle; liver; living donor; metabolism; pathology; reperfusion injury; sexual characteristics | English | 2022 | 2022-02 | 10.1097/tp.0000000000003705 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | The Efficacy and Safety of SGLT2 Inhibitor in Diabetic Kidney Transplant Recipients | Background. The efficacy and safety of sodium-glucose cotransporter 2 inhibitors (SGLT2i) have not been investigated in kidney transplant recipients (KTRs) with diabetes. We evaluated the impact of SGLT2i in a multicenter cohort of diabetic KTRs. Methods. A total of 2083 KTRs with diabetes were enrolled from 6 transplant centers in Korea. Among them, 226 (10.8%) patients were prescribed SGLT2i for >90 d. The primary outcome was a composite outcome of all-cause mortality, death-censored graft failure (DCGF), and serum creatinine doubling. An acute dip in estimated glomerular filtration rate (eGFR) over 10% was surveyed after SGLT2i use. Results. During the mean follow-up of 62.9 +/- 42.2 mo, the SGLT2i group had a lower risk of primary composite outcome than the control group in the multivariate and propensity score-matched models (adjusted hazard ratio, 0.43; 95% confidence interval, 0.24-0.78; P = 0.006 and adjusted hazard ratio, 0.45; 95% confidence interval, 0.24-0.85; P = 0.013, respectively). Multivariate analyses consistently showed a decreased risk of DCGF and serum creatinine doubling in the SGLT2i group. The overall eGFR remained stable without the initial dip after SGLT2i use. A minority (15.6%) of the SGLT2i users showed acute eGFR dip during the first month, but the eGFR recovered thereafter. The risk factors for the eGFR dip were time from transplantation to SGLT2i usage and mean tacrolimus trough level. Conclusions. SGLT2i improved a composite of all-cause mortality, DCGF, or serum creatinine doubling in KTRs. SGLT2i can be used safely and have beneficial effects on preserving graft function in diabetic KTRs. | Lim, Jeong-Hoon; Kwon, Soie; Jeon, Yena; Kim, Young Hoon; Kwon, Hyunwook; Kim, Yon Su; Lee, Hajeong; Kim, Yong-Lim; Kim, Chan-Duck; Park, Sun-Hee; Lee, Jong Soo; Yoo, Kyung Don; Son, Hyung Eun; Jeong, Jong Cheol; Lee, Jeonghwan; Lee, Jung Pyo; Cho, Jang-Hee | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Seoul Natl Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Kyungpook Natl Univ, Dept Stat, Daegu, South Korea; Asan Med Ctr, Dept Surg, Div Kidney Transplantat, Seoul, South Korea; Univ Ulsan, Coll Med, Seoul, South Korea; Univ Ulsan, Ulsan Univ Hosp, Dept Internal Med, Div Nephrol,Coll Med, Ulsan, South Korea; Seoul Natl Univ, Dept Internal Med, Bundang Hosp, Seongnam, South Korea; Seoul Natl Univ, Dept Internal Med, Boramae Med Ctr, Seoul, South Korea | Lim, Jeong-Hoon/ABE-6003-2020; Kim, Yong-Lim/AGK-3172-2022; Lee, Jun-Young/N-5963-2019; Lee, Sang-Oh/AGV-5413-2022; Lee, Jeonghwan/C-5214-2011; Yoo, Kyung/AAK-8096-2020; Park, Sun-Hee/LMN-0033-2024; Kim, Young-Hoon/E-5614-2012; Cho, Jang-hee/ABD-3534-2020; Lee, Hyo/G-6299-2019 | 55360244300; 57206477140; 57209909350; 57281310600; 56306126900; 7410205767; 36554389800; 55633533600; 8558530700; 7501831741; 57201264463; 56603636300; 57208427093; 37761626800; 57203144567; 56028990400; 7403536291 | nephrolee@gmail.com;jh-cho@knu.ac.kr; | TRANSPLANTATION | TRANSPLANTATION | 0041-1337 | 1534-6080 | 106 | 9 | SCIE | IMMUNOLOGY;SURGERY;TRANSPLANTATION | 2022 | 6.2 | 5.4 | 9.35 | 2025-06-25 | 56 | 64 | ALLOGRAFT SURVIVAL; MELLITUS; EMPAGLIFLOZIN; ASSOCIATIONS; RISK | Creatinine; Diabetes Mellitus, Type 2; Glomerular Filtration Rate; Humans; Kidney Transplantation; Sodium-Glucose Transporter 2 Inhibitors; Transplant Recipients; dapagliflozin; empagliflozin; hemoglobin A1c; sodium glucose cotransporter 2 inhibitor; tacrolimus; creatinine; adult; all cause mortality; area under the curve; Article; cohort analysis; controlled study; creatinine blood level; diabetic nephropathy; diagnostic test accuracy study; drug efficacy; drug safety; end stage renal disease; estimated glomerular filtration rate; female; graft failure; graft recipient; human; hypertension; ICD-10; ketoacidosis; ketonuria; kidney graft; major clinical study; male; middle aged; mycosis; propensity score; receiver operating characteristic; renal replacement therapy; retrospective study; adverse event; clinical trial; complication; glomerulus filtration rate; graft recipient; kidney transplantation; multicenter study; non insulin dependent diabetes mellitus | English | 2022 | 2022-09 | 10.1097/tp.0000000000004228 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Meeting Abstract | Transarterial chemoembolization (TACE) with radiotherapy for solitary HCC bone metastasis after living donor liver transplantation | Han, J.; Han, Y. S. | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Liver Transplantat & Hepatobiliary Pancreas Surg, Daegu, South Korea | TRANSPLANTATION | TRANSPLANTATION | 0041-1337 | 1534-6080 | 106 | 8S | SCIE | IMMUNOLOGY;SURGERY;TRANSPLANTATION | 2022 | 6.2 | 5.4 | 0 | English | 2022 | 2022-08 | 바로가기 | 바로가기 | ||||||||||||||||
| ○ | ○ | Article | Fingerprint inspired advanced end-effector and its applications | The human fingertip consists of a fingerprint with many micro-grating structures. The main roles of the fingerprint could be divided into two purposes, namely, the enhancement of the frictional force and the effective transmittance of the biosignal. In this study, we present the fingerprint-inspired end-effector that has not only admirable frictional force but also electric conductivity. The end-effector is composed of fluorocarbon rubber, one of the famous materials to achieve high frictional force and robustness. Through various experiments, the novel performance of micro structured fluorocarbon rubber end-effector (MSFE) is characterized by comparing with a macroscale patterned sample (MPS), which has been already used in real industrial fields. Experimental results are analyzed theoretically. Furthermore, as feasible applications, we suggest two applications based on the role of the fingerprint. One is the conductive astronaut glove with high frictional force, and the other one is a non-slip pad for the next-generation glass transfer systems. Through these experiments, we successfully observe the enhanced system performance and confirm the possibility of using the MSFE as feasible applications. We believe that the MSFE could be a useful and powerful alternative as an end-effector, not only in the aerospace industry but also in display manufacturing processes. | Lee, Sung Ho; Kim, Hyo Sung; Park, Han Jun; Kwak, Moon Kyu | Univ Michigan, Dept Elect Engn & Comp Sci, Ann Arbor, MI 48109 USA; Kyungpook Natl Univ, Dept Mech Engn, Daegu 41566, South Korea | ; Kwak, Moon/AGQ-6058-2022 | 56195582600; 59283618800; 57455185400; 57203947984 | mkkwak@knu.ac.kr; | FRICTION | FRICTION | 2223-7690 | 2223-7704 | 10 | 10 | SCIE | ENGINEERING, MECHANICAL | 2022 | 6.8 | 5.5 | 0.17 | 2025-06-25 | 2 | 2 | fingerprint; end-effector; fluorocarbon rubber (FKM); glass transfer system; spacesuit | DRY ADHESIVE; ELECTRICAL-CONDUCTIVITY; CONTACT; DISPERSION; FILLERS | end-effector; fingerprint; fluorocarbon rubber (FKM); glass transfer system; spacesuit | Aerospace industry; End effectors; Friction; Rubber; Fingerprint; Fluorocarbon rubber (FKM); Fluorocarbon rubbers; Frictional forces; Glass transfer system; Grating structures; ITS applications; Micro gratings; Spacesuit; Transfer systems; Glass | English | 2022 | 2022-10 | 10.1007/s40544-022-0612-y | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Macitentan improves antitumor immune responses by inhibiting the secretion of tumor-derived extracellular vesicle PD-L1 | Extracellular vesicles (EVs) carrying tumor cell-derived programmed death-ligand 1 (PD-L1) interact with programmed death 1 (PD-1)-producing T cells, thus significantly lowering a patient's response to immune checkpoint blockade drugs. No drug that reinvigorates CD8+ T cells by suppressing EV PD-L1 has been approved for clinical usage. Here we have identified macitentan (MAC), an FDA-approved oral drug, as a robust booster of antitumor responses in CD8+ T cells by suppressing tumor cell-derived EV PD-L1. Methods: EV was analyzed by the data from nanoparticle tracking, immunoblotting analyses, and nano-flow cytometry. Antitumor immunity was evaluated by luciferase assay and immune phenotyping using flow cytometry. Clinical relevance was analyzed using the cancer genome atlas database. Results: MAC inhibited secretion of tumor-derived EV PD-L1 by targeting the endothelin receptor A (ETA) in breast cancer cells and xenograft models. MAC enhanced CD8+ T cell-mediated tumor killing by decreasing the binding of PD-1 to the EV PD-L1 and thus synergizing the effects of the anti-PD-L1 antibody. MAC also showed an anticancer effect in triple-negative breast cancer (TNBC)-bearing immunocompetent mice but not in nude mice. The combination therapy of MAC and anti-PD-L1 antibody significantly improved antitumor efficacy by increasing CD8+ T cell number and activity with decreasing Treg number in the tumors and draining lymph nodes in TNBC, colon, and lung syngeneic tumor models. The antitumor effect of MAC was reversed by injecting exogenous EV PD-L1. Notably, ETA level was strongly associated with the innate anti-PD-1 resistance gene signature and the low response to the PD-1/PD-L1 blockade. Conclusion: These findings strongly demonstrate that MAC, already approved for clinical applications, can be used to improve and/or overcome the inadequate response to PD-1/PD-L1 blockade therapy. | Lee, Chan-Hyeong; Bae, Ju-Hyun; Choe, Eun-Ji; Park, Ju-Mi; Park, Seong-Sik; Cho, Hee Jin; Song, Byoung-Joon; Baek, Moon-Chang | Kyungpook Natl Univ, Sch Med, Exosome Convergence Res Ctr ECRC, Dept Mol Med,CMRI, Daegu, South Korea; Kyungpook Natl Univ, Dept Biomed Convergence Sci & Technol, Daegu, South Korea; NIAAA, Sect Mol Pharmacol & Toxicol, Lab Membrane Biochem & Biophys, NIH, Bethesda, MD USA | 57189904697; 57225046295; 57377017300; 57221984091; 57378111300; 55937716400; 7402560465; 7006013097 | mcbaek@knu.ac.kr; | THERANOSTICS | THERANOSTICS | 1838-7640 | 12 | 5 | SCIE | MEDICINE, RESEARCH & EXPERIMENTAL | 2022 | 12.4 | 5.5 | 10.85 | 2025-06-25 | 76 | 74 | Exosome; Extracellular vesicle; Cancer; immunotherapy; PD-L1 | ENDOTHELIN RECEPTOR ANTAGONIST; BREAST-CANCER; EXOSOMES; IMMUNOSUPPRESSION; IDENTIFICATION; EXPRESSION; SURVIVAL; EFFICACY; HYPOXIA; CMTM6 | Cancer; Exosome; Extracellular vesicle; Immunotherapy; PD-L1 | Animals; B7-H1 Antigen; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Extracellular Vesicles; Humans; Immunity; Lung Neoplasms; Mice; Mice, Nude; Programmed Cell Death 1 Receptor; Pyrimidines; Sulfonamides; Triple Negative Breast Neoplasms; ambrisentan; bosentan; macitentan; programmed death 1 ligand 1; sulfafurazole; CD274 protein, human; macitentan; programmed death 1 ligand 1; programmed death 1 receptor; pyrimidine derivative; sulfonamide; animal cell; animal experiment; animal model; animal tissue; antineoplastic activity; Article; cancer growth; CD8+ T lymphocyte; cell isolation; cell viability; cellular secretion; colon cancer; controlled study; exosome; female; flow cytometry; gene expression; human; human cell; immune response; immunoblotting; immunohistochemistry; immunophenotyping; in vitro study; in vivo study; innate immunity; luciferase assay; lymphocyte count; mouse; nonhuman; protein secretion; regulatory T lymphocyte; transmission electron microscopy; triple negative breast cancer; tumor gene; Western blotting; animal; immunity; lung tumor; metabolism; nude mouse; triple negative breast cancer; tumor cell line | English | 2022 | 2022 | 10.7150/thno.68864 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | A Quadratic Quasi-Z-Source Full-Bridge Isolated DC-DC Converter With High Reliability for Wide Input Applications | In this article, two configurations of the quadratic quasi-Z-source (Q-qZS) isolated dc-dc converters are presented, namely continuous input current and discontinuous input current configurations. The operating principles and steady state of the continuous input current topology analyzed in this article is characterized with the following features: 1) wider operating range due to buck and boost functions in a single stage; 2) draws continuous input current; 3) low input current ripple compared with other qZS-based isolated dc-dc converters; 4) better reliability and good immunity against EMI noise; 5) common ground between the input source and the inverting bridge; and 6) continuous control over the entire operating range. Compared with other qZS-based isolated dc-dc converters, lower current stresses on active and passive components used are realized. Hence, the total magnetic volume/energy required by the proposed converter is reduced with the potential of achieving high power density. A prototype of 40-140 V input voltage, 300 V output, and 550 W rated power is developed to validate the performance of the proposed converter presented. | Oluwasogo, Emmanuel S.; Cha, Honnyong | Kyungpook Natl Univ, Sch Energy Engn, Daegu 41566, South Korea | Oluwasogo, Emmanuel/AAG-1003-2021 | 57221907765; 24450248400 | olemstag@gmail.com;chahonny@knu.ac.kr; | IEEE TRANSACTIONS ON INDUSTRIAL ELECTRONICS | IEEE T IND ELECTRON | 0278-0046 | 1557-9948 | 69 | 10 | SCIE | AUTOMATION & CONTROL SYSTEMS;ENGINEERING, ELECTRICAL & ELECTRONIC;INSTRUMENTS & INSTRUMENTATION | 2022 | 7.7 | 5.6 | 2.12 | 2025-06-25 | 17 | 28 | DC-DC power converters; Topology; Reliability; Stress; Inductors; Magnetomechanical effects; Electromagnetic interference; Buck-boost; isolated dc-dc power conversion; quadratic quasi-Z-source (Q-qZS); reliability; wide input applications | ISOLATED DC/DC CONVERTER; VOLTAGE RANGE; DESIGN | Buck'boost; isolated dc'dc power conversion; quadratic quasi-Z-source (Q-qZS); reliability; wide input applications | Boost converter; Electric inverters; Buck-boost; D.c.-d.c. power conversions; Dc/dc power conversions; Input applications; Input current; Isolated dc'dc power conversion; Isolated dc/dc converters; Quadratic quasi-Z-source; Wide input application; Z-Source; Reliability | English | 2022 | 2022-10 | 10.1109/tie.2022.3159955 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Algorithm Unrolling for Massive Access via Deep Neural Networks With Theoretical Guarantee | Massive access is a critical design challenge of Internet of Things (IoT) networks. In this paper, we consider the grant-free uplink transmission of an IoT network with a multiple-antenna base station (BS) and a large number of single-antenna IoT devices. Taking into account the sporadic nature of IoT devices, we formulate the joint activity detection and channel estimation (JADCE) problem as a group-sparse matrix estimation problem. This problem can be solved by applying the existing compressed sensing techniques, which however either suffer from high computational complexities or lack of algorithm robustness. To this end, we propose a novel algorithm unrolling framework based on the deep neural network to simultaneously achieve low computational complexity and high robustness for solving the JADCE problem. Specifically, we map the original iterative shrinkage thresholding algorithm (ISTA) into an unrolled recurrent neural network (RNN), thereby improving the convergence rate and computational efficiency through end-to-end training. Moreover, the proposed algorithm unrolling approach inherits the structure and domain knowledge of the ISTA, thereby maintaining the algorithm robustness, which can handle non-Gaussian preamble sequence matrix in massive access. With rigorous theoretical analysis, we further simplify the unrolled network structure by reducing the redundant training parameters. Furthermore, we prove that the simplified unrolled deep neural network structures enjoy a linear convergence rate. Extensive simulations based on various preamble signatures show that the proposed unrolled networks outperform the existing methods in terms of the convergence rate, robustness and estimation accuracy. | Shi, Yandong; Choi, Hayoung; Shi, Yuanming; Zhou, Yong | ShanghaiTech Univ, Sch Informat Sci & Technol, Shanghai 201210, Peoples R China; Chinese Acad Sci, Shanghai Inst Microsyst & Informat Technol, Shanghai 200050, Peoples R China; Univ Chinese Acad Sci, Beijing 100049, Peoples R China; Kyungpook Natl Univ, Dept Math, Daegu 41566, South Korea; Yoke Intelligence, Shanghai 201210, Peoples R China | Shi, Yuanming/LSK-2577-2024; Choi, Hayoung/U-7046-2019; shi, yandong/IWV-4399-2023 | 57215898372; 56942685000; 55695283900; 35732808900 | shiyd@shanghaitech.edu.cn;hayoung.choi@knu.ac.kr;shiym@shanghaitech.edu.cn;zhouyong@shanghaitech.edu.cn; | IEEE TRANSACTIONS ON WIRELESS COMMUNICATIONS | IEEE T WIREL COMMUN | 1536-1276 | 1558-2248 | 21 | 2 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC;TELECOMMUNICATIONS | 2022 | 10.4 | 5.6 | 2.8 | 2025-06-25 | 24 | 29 | Deep learning; Convergence; Estimation; Training; Robustness; Internet of Things; Approximation algorithms; Massive access; joint activity detection and channel estimation; group-sparse matrix estimation; algorithm unrolling; deep learning | CHANNEL ESTIMATION; MULTIUSER DETECTION; TRAINABLE ISTA; SIGNAL; CONNECTIVITY; INTERNET; LASSO | algorithm unrolling; deep learning; group-sparse matrix estimation; joint activity detection and channel estimation; Massive access | Antennas; Channel estimation; Computational complexity; Computational efficiency; Domain Knowledge; Internet of things; Iterative methods; Recurrent neural networks; Activity detection; Algorithm unrolling; Deep learning; Group sparse; Group-sparse matrix estimation; Joint activity; Joint activity detection and channel estimation; Massive access; Matrix estimation; Sparse matrices; Deep neural networks | English | 2022 | 2022-02 | 10.1109/twc.2021.3100500 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Beta-Quasi-Z-Source (β-qZS) DC-DC Converter Without Duty Cycle Constraint or Wide Input Voltage Applications | A novel beta-quasi-Z-source (beta-qZS) converter is proposed for an isolated dc-dc converter with the buck (step-down) and boost (step-up) functions. The beta-qZS isolated dc-dc converter addresses the common challenges such as components stresses, reliability, suppression of switch voltage overshoot, size, and power derating in the existing impedance source-based isolated dc-dc converter applications. In addition, the proposed topology dealt with operating duty cycle constraint and loss of duty cycle phenomenon in the Z/qZS galvanically isolated dc-dc converters. This article describes the configuration and provides the principle of operation for the proposed beta-qZS converter topology. A laboratory prototype is developed, and the experimental results satisfy the theoretical analysis. | Oluwasogo, Emmanuel; Cha, Honnyong; Tien Nguyen | Kyungpook Natl Univ, Sch Energy Engn, Daegu 41566, South Korea | Oluwasogo, Emmanuel/AAG-1003-2021; Nguyen, Tien/ABX-3214-2022 | 57221907765; 24450248400; 59454647000 | olem-stag@knu.ac.kr;chahonny@knu.ac.kr;thetien93@knu.ac.kr; | IEEE TRANSACTIONS ON INDUSTRIAL ELECTRONICS | IEEE T IND ELECTRON | 0278-0046 | 1557-9948 | 69 | 12 | SCIE | AUTOMATION & CONTROL SYSTEMS;ENGINEERING, ELECTRICAL & ELECTRONIC;INSTRUMENTS & INSTRUMENTATION | 2022 | 7.7 | 5.6 | 0.68 | 2025-06-25 | 5 | 9 | Buck-boost; dc-dc converter; galvanic isolation; impedance source converter (ISC); quasi-z-source (qZS) converter; reliability | Buck-boost; dc-dc converter; galvanic isolation; impedance source converter (ISC); quasi-z-source (qZS) converter; reliability | DC transformers; Electric inverters; Topology; Voltage regulators; Buck-boost; DC/DC power converters; Galvanic isolation; Impedance source converter; Impedance sources; Inductor; Power conversion; Quasi-Z-source converter; Transformer; Z-Source; DC-DC converters | English | 2022 | 2022-12 | 10.1109/tie.2021.3130324 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Comparison of antimicrobial resistance and molecular characterization of Escherichia coli isolates from layer breeder farms in Korea | In Korea, 4 big layer companies that possess one grandparent and 3 parent stocks are in charge of 100% of the layer chicken industry. In this study, we investigated the antimicrobial resistance of commensal 578 E. coli isolated from 20 flocks of 4-layer breeder farms (A, B, C, and D), moreover, compared the characteristics of their resistance and virulence genes. Isolates from farms B and D showed significantly higher resistance to the beta-lactam antimicrobials (amoxicillin, ampicillin, and 1st-, 2nd-, and 3rd-generation cephalosporins). However, resistance to ciprofloxacin, nalidixic acid, and tetracycline was significantly higher in the isolates from farm A (P < 0.05). Interestingly, the isolates from farm C showed significantly lower resistance to most antimicrobials tested in this study. The isolates from farms B, C, and D showed the high multiple resistance to the 3 antimicrobial classes. Furthermore, the isolates from farm A showed the highest multiple resistance against the 5 classes. Among the 412 beta-lactam-resistant isolates, 123 (29.9%) carried bla(TEM-1), but the distribution was significantly different among the farms from 17.5% to 51.4% (P < 0.05). Similarly, the most prevalent tetracycline resistance gene in the isolates from farms B, C, and D was tetA (50.0-77.0%); however, the isolates from farm A showed the highest prevalence in tetB (70.6%). The distribution of quinolone (qnrB, qnrD, and qnrS) and sulfonamide (su12)-resistant genes were also significantly different among the farms but that of chloramphenicol (catA1)- and aminoglycoside (aac [3]-II, and aac [6']-Ib)-resistant genes possessed no significant difference among the farms. Moreover, the isolates from farm C showed significantly higher prevalence in virulence genes (iroN, ompT, hlyF, and iss) than the other 3 farms (P < 0.05). Furthermore, the phenotypic and genotypic characteristics of E. coli isolates were significantly different among the farms, and improved management protocols are required to control of horizontal and vertical transmission of avian disease, including the dissemination of resistant bacteria in breeder flocks. | Kim, Dong Gyu; Kim, Koeun; Bae, Sung Hyun; Jung, Hye-Ri; Kang, Hyo Jung; Lee, Yu Jin; Seo, Kwang Won; Lee, Young Ju | Kyungpook Natl Univ, Coll Vet Med, Daegu 41566, South Korea; Kyungpook Natl Univ, Zoonoses Res Inst, Daegu 41566, South Korea; Chungbuk Natl Univ, Coll Vet Med, Lab Vet Bacteriol & Infect Dis, Cheongju 28644, South Korea | 57353334400; 57220805028; 57226498230; 57265190900; 57224364605; 57352999000; 57203233812; 56612134500 | youngju@knu.ac.kr; | POULTRY SCIENCE | POULTRY SCI | 0032-5791 | 1525-3171 | 101 | 1 | SCIE | AGRICULTURE, DAIRY & ANIMAL SCIENCE | 2022 | 4.4 | 5.6 | 1.33 | 2025-06-25 | 6 | 7 | Escherichia coli; layer parent stock; antimicrobial resistance | MEDIATED QUINOLONE RESISTANCE; SPECTRUM BETA-LACTAMASES; ANTIBIOTIC-RESISTANCE; ENTEROCOCCUS-FAECALIS; RAW MEAT; GENES; VIRULENCE; DETERMINANTS; PREVALENCE; STRAINS | antimicrobial resistance; Escherichia coli; layer parent stock | Animals; Anti-Bacterial Agents; Chickens; Drug Resistance, Bacterial; Escherichia coli; Farms; Republic of Korea; antiinfective agent; agricultural land; animal; antibiotic resistance; chicken; Escherichia coli; genetics; South Korea | English | 2022 | 2022-01 | 10.1016/j.psj.2021.101571 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Cooperative Distributed GPU Power Capping for Deep Learning Clusters | The recent GPU-based clusters that handle deep learning (DL) tasks have the features of GPU device heterogeneity, a variety of deep neural network (DNN) models, and high computational complexity. Thus, the traditional power capping methods for CPU-based clusters or small-scale GPU devices cannot be applied to the GPU-based clusters handling DL tasks. This article develops a cooperative distributed GPU power capping (CD-GPC) system for GPU-based clusters, aiming to minimize the training completion time of invoked DL tasks without exceeding the limited power budget. Specifically, we first design the frequency scaling approach using the online model estimation based on the recursive least square method. This approach achieves the accurate tuning for DL task training time and power usage of GPU devices without needing offline profiling. Then, we formulate the proposed FS problem as a Lagrangian dual decomposition-based economic model predictive control problem for large-scale heterogeneous GPU clusters. We conduct both the NVIDIA GPU-based labscale real experiments and real job trace-based simulation experiments for performance evaluation. Experimental results validate that the proposed system improves the power capping accuracy to have a mean absolute error of <1%, and reduces the deadline violation ratio of invoked DL tasks by 21.5% compared with other recent counterparts. | Kang, Dong-Ki; Ha, Yun-Gi; Peng, Limei; Youn, Chan-Hyun | Jeonbuk Natl Univ, Dept Informat Technol, Jeonju 54896, South Korea; Korea Adv Inst Sci & Technol, Sch Elect Engn, Daejeon 34141, South Korea; Kyungpook Natl Univ, Sch Comp Sci & Engn, Daegu 41566, South Korea | ; Youn, Chan-Hyun/C-1729-2011 | 36166726400; 57205425856; 7201574271; 35197464700 | dongkikang@jbnu.ac.kr;yungi.ha@kaist.ac.kr;auroraplm@knu.ac.kr;chyoun@kaist.ac.kr; | IEEE TRANSACTIONS ON INDUSTRIAL ELECTRONICS | IEEE T IND ELECTRON | 0278-0046 | 1557-9948 | 69 | 7 | SCIE | AUTOMATION & CONTROL SYSTEMS;ENGINEERING, ELECTRICAL & ELECTRONIC;INSTRUMENTS & INSTRUMENTATION | 2022 | 7.7 | 5.6 | 0.76 | 2025-06-25 | 9 | 10 | Deep learning (DL) cluster; economic model predictive control (EMPC); GPU power capping; Lagrangian dual decomposition; Lipschitz continuity | DECOMPOSITION; TUTORIAL | Deep learning (DL) cluster; Economic model predictive control (EMPC); GPU power capping; Lagrangian dual decomposition; Lipschitz continuity | Budget control; Deep neural networks; Dynamic frequency scaling; Frequency estimation; Graphics processing unit; Least squares approximations; Model predictive control; Predictive control systems; Device heterogeneities; Economic modeling; Frequency-scaling; Lagrangian-dual decompositions; Mean absolute error; Online modeling; Recursive least square methods; Trace-based simulation; Deep learning | English | 2022 | 2022-07 | 10.1109/tie.2021.3095790 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Design Optimization of Asymmetric Patterns for Variable Stiffness of Continuum Tubular Robots | Variable stiffness mechanisms have become popular for improving the performance of meso/microscale robots due to their ability to enable safe, effective, and versatile operation without additional actuators. In minimally invasive surgery (MIS), they can provide low stiffness for adaptability and an extended workspace and high stiffness for stable manipulation. This study aims to optimize the pattern design that maximizes the stiffness ratio while preventing buckling. Longitudinal slits are identified as the ideal shape for maximizing the ratio using topology optimization. The effects of the design parameters are investigated by analytical modeling and finite-element analysis (FEA). Finally, we established a design optimization process to maximize the variable stiffness ratio while ensuring safety. The load and buckling tests of 19 cases are verified in both the experiment and FEA. Buckling occurred in eight cases, consistent with the expected results from the proposed map. Among the tested cases, the tube with the optimal pattern parameter set exhibits the highest stiffness ratio of 2.67 while satisfying the given stiffness constraint (greater than 0.3 times the flexural stiffness of the initial tube) and avoiding buckling. The proposed optimization method potentially enables an extended workspace and more versatile functionality for MIS instruments. | Park, Soyeon; Kim, Jongwoo; Kim, Chunwoo; Cho, Kyu-Jin; Noh, Gunwoo | Korea Univ, Sch Mech Engn, Computat Mech & Design Optimizat Lab, Seoul 02841, South Korea; Kyungpook Natl Univ, Sch Mech Engn, Daegu 41566, South Korea; Kyung Hee Univ, Dept Mech Engn, Gyeonggi Do 17104, South Korea; Univ Toronto, Robot Inst, Toronto, ON M5S 1A1, Canada; Korea Inst Sci & Technol, Ctr Healthcare Robot, Seoul 02792, South Korea; Seoul Natl Univ, Biorobot Lab, Dept Mech Engn, Seoul 08826, South Korea | ; Kim, Jongwoo/AAN-5575-2020 | 59609350600; 56742819400; 37074869000; 7403956407; 55010264000 | soyeonp11@knu.ac.kr;jongwoo.kim@mail.utoronto.ca;cwkim@kist.re.kr;kjcho@snu.ac.kr;gunwoonoh@korea.ac.kr; | IEEE TRANSACTIONS ON INDUSTRIAL ELECTRONICS | IEEE T IND ELECTRON | 0278-0046 | 1557-9948 | 69 | 8 | SCIE | AUTOMATION & CONTROL SYSTEMS;ENGINEERING, ELECTRICAL & ELECTRONIC;INSTRUMENTS & INSTRUMENTATION | 2022 | 7.7 | 5.6 | 1.51 | 2025-06-25 | 19 | 20 | Electron tubes; Robots; Optimization; Shape; Topology; Service robots; Bending; Mechanism design; medical robots and systems; steerable catheters; needles; surgical robotics; variable stiffness mechanism | TOPOLOGY OPTIMIZATION; CAPABILITY; MECHANISM; PROBE | Mechanism design; medical robots and systems; steerable catheters/needles; surgical robotics; variable stiffness mechanism | Buckling; Machine design; Robots; Asymmetric patterns; Design optimization; Design parameters; Flexural stiffness; Minimally invasive surgery; Optimization method; Variable stiffness; Variable stiffness mechanism; Stiffness | English | 2022 | 2022-08 | 10.1109/tie.2021.3104604 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Dual-Active-Half-Bridge Converter With Output Voltage Balancing Scheme for Bipolar DC Distribution System | Conventional dual-active-bridge dc-dc converters require a dedicated voltage balancer or feedback control when they are used for a bipolar LVdc distribution system. This article proposes a dual-active-half-bridge (DAHB) converter with voltage balancing. The proposed converter is composed of a conventional DAHB converter with an additional inductor and capacitor voltage balancer (LCVB). The LCVB is added between the transformer and the output of the DAHB converter. Although the LCVB increases the switch current, it can balance the two output voltages without additional active switching device and feedback control under unbalanced load conditions. In addition, compared with the conventional DAHB converter, the LCVB can increase the zero-voltage-switching range of the DAHB converter and has no detrimental effect on the operation modes and performances. A 2.8-kW prototype was built and tested to verify the performances of the proposed converter. | Kim, Kisu; Cha, Honnyong | Kyungpook Natl Univ, Sch Energy Engn, Daegu 41566, South Korea | Kim, Kisu/LBH-7363-2024 | 57195371307; 24450248400 | kimkisu1027@knu.ac.kr;chahonny@knu.ac.kr; | IEEE TRANSACTIONS ON INDUSTRIAL ELECTRONICS | IEEE T IND ELECTRON | 0278-0046 | 1557-9948 | 69 | 7 | SCIE | AUTOMATION & CONTROL SYSTEMS;ENGINEERING, ELECTRICAL & ELECTRONIC;INSTRUMENTS & INSTRUMENTATION | 2022 | 7.7 | 5.6 | 3.18 | 2025-06-25 | 34 | 42 | Switches; Circuit faults; Inductors; Voltage control; Feedback control; DC distribution systems; Capacitors; Bipolar dc distribution system; dual-active-half-bridge (DAHB); voltage balancing; zero voltage switching (ZVS) | Bipolar dc distribution system; dual-active-half-bridge (DAHB); voltage balancing; zero voltage switching (ZVS) | Balancing; DC power transmission; Feedback control; Zero voltage switching; Capacitor voltages; DC distribution system; Distribution systems; Dual active bridges; Dual active half bridges (DAHB); Half-bridge converters; Switching devices; Voltage balancing; DC-DC converters | English | 2022 | 2022-07 | 10.1109/tie.2021.3099233 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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