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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Network Structure of Interpersonal Sensitivity in Patients With Mood Disorders: A Network Analysis | Objective Interpersonal sensitivity, characterized by a heightened awareness of others' behavior and emotions, is linked to mood disorders. However, current literature lacks a comprehensive analysis of how some items of the Interpersonal Sensitivity Measure (IPSM) interrelate and contribute to the overall construct. This study constructed a network for interpersonal sensitivity symptomatology to identify core IPSM items in patients with mood disorders. Methods The IPSM, a 36-item self-report scale, was utilized to evaluate interpersonal sensitivity symptoms in 837 participants (major depressive disorder [MDD], n=265; bipolar I disorder [BD I], n=126; and bipolar II disorder [BD II], n=446). We performed exploratory graph analysis, employing regularized partial correlation models to estimate the network structure. Centrality analysis identified core IPSM symptoms for each mood disorder group. Network comparison tests assessed structural differences between the MDD and BD subgroups. Results Network analysis detected five communities. Item 10 ("I worry about being criticized for things that I have said or done") showed the highest value in strength. Multiple items on "Interpersonal Worry/Dependency" and "Low Self-Esteem" showed high strength centrality. Network structure invariance and global strength invariance test results indicated no significant differences between the MDD and BD subgroups. Conclusion Our findings emphasize the importance of addressing "Interpersonal Worry/Dependency" and "Low Self-Esteem" in the IPSM network among mood disorder patients based on core items of the network. Additionally, targeted treatments and comprehensive strategies in this aspect could be crucial for managing mood disorders. | Kim, Yuna; Jang, Junwoo; Kang, Hyo Shin; Lee, Jakyung; Lee, Daseul; Yu, Hyeona; Jang, Yoonjeong; Yoon, Joohyun; Lee, Hyukjun; Ha, Tae Hyon; Park, Jungkyu; Myung, Woojae | Seoul Natl Univ, Bundang Hosp, Dept Neuropsychiat, 82 Gumi Ro 173beon Gil, Seongnam 13620, South Korea; Kyungpook Natl Univ, Dept Psychol, 80 Daehak Ro, Daegu 41566, South Korea; Seoul Natl Univ, Coll Med, Dept Psychiat, Seoul, South Korea; Seoul Natl Univ, Bundang Hosp, Dept Neuropsychiat, Seongnam, South Korea | ; Jang, Yoonjeong/LKN-3419-2024; Myung, Woojae/AAD-3016-2021; Ha, Tae/U-5558-2019 | 58553547100; 58846141500; 57219595147; 57972918600; 57973764300; 57910913300; 57223872445; 57226706803; 58749939700; 7203014550; 56206565000; 37099034100 | jkp@knu.ac.kr;wmyung@snu.ac.kr; | PSYCHIATRY INVESTIGATION | PSYCHIAT INVEST | 1976-3026 | 21 | 9 | SCIE;SSCI | PSYCHIATRY | 2024 | 1.8 | 63.0 | 0 | 2025-05-07 | 0 | 0 | Keywords Interpersonal relation; Major depressive disorder; Bipolar disorder; Mood disorder. | PSYCHOMETRIC PROPERTIES; SYMPTOMS | Bipolar disorder; Interpersonal relation; Major depressive disorder; Mood disorder | adult; Article; bipolar disorder; bipolar I disorder; bipolar II disorder; confirmatory factor analysis; construct validity; depression; DSM-5; female; human; interpersonal sensitivity; Likert scale; major clinical study; major depression; male; mini international neuropsychiatric interview; mood disorder; network analysis; questionnaire; sensitivity analysis; social psychology; symptomatology; test retest reliability | English | 2024 | 2024-09 | 10.30773/pi.2023.0411 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Standardization of the Korean Version of the Acceptance and Action Questionnaire for Obsessions and Compulsions in University Students and Patients With Obsessive-Compulsive Disorder | Objective The Acceptance and Action Questionnaire for Obsessions and Compulsions (AAQ-OC) is a version of the Acceptance and Action Questionnaire (AAQ) that specifically measures unwanted intrusive thoughts and responses (e.g., experiential avoidance) to them. This study aimed to investigate the reliability and validity of the Korean version of the AAQ-OC in clinical and nonclinical Korean samples. Methods In this study, 561 university students and 121 patients with obsessive-compulsive disorder (OCD) completed the AAQ-OC and several other psychological scales. Descriptive, correlation, and exploratory and confirmatory factor analyses as well as group comparisons were conducted. Results The results of the exploratory and confirmatory factor analyses indicated a two -factor structure that best fits the data in the university sample: Factors 1 and 2 matched the original Valued Action and Willingness subscales, respectively. The reliability analyses revealed that the AAQ-OC and its factors had excellent internal consistencies. As regards the concurrent validity, the AAQ-OC and its factors had a positive correlation with the AAQ-II and Cognitive Fusion Questionnaire. Compared with the university students, the OCD patients had higher AAQ-OC scores, and their obsessive-compulsive symptoms, particularly the two symptom dimensions of responsibility for harm and mistakes and unacceptable thoughts, were significantly associated with the AAQ-OC and two subscales. Conclusion The findings of this study confirm the reliability and validity of the Korean version of the AAQ-OC. | Lee, Seung Jae; Lee, Sang Won; Choi, Mina | Kyungpook Natl Univ, Sch Med, Dept Psychiat, Taegu, South Korea; Kyungpook Natl Univ Hosp, Dept Psychiat, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Psychiat, Daegu, South Korea; Kyungpook Natl Univ, Inst Biomed Engn Res, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Psychiat, 680 Gukchaebosang ro, Daegu 41944, South Korea | Lee, Seung/AAI-1191-2020 | 58509400200; 55820414800; 58010223000 | jayleemd@knu.ac.kr; | PSYCHIATRY INVESTIGATION | PSYCHIAT INVEST | 1976-3026 | 21 | 3 | SCIE;SSCI | PSYCHIATRY | 2024 | 1.8 | 63.0 | 0.57 | 2025-05-07 | 1 | 1 | Psychological flexibility; Experiential avoidance; Cognitive fusion; Obsessive-compulsive disorder; Psychometric | COMMITMENT THERAPY; EXPERIENTIAL AVOIDANCE; PSYCHOLOGICAL INFLEXIBILITY; PSYCHOMETRIC PROPERTIES; SYMPTOM DIMENSIONS; METAANALYSIS; VALIDATION; CONTEXT; TRIAL | Cognitive fusion; Experiential avoidance; Obsessive–compulsive disorder; Psychological flexibility; Psychometric | Acceptance and Action Questionnaire for Obsessions and Compulsions; acceptance and action questionnaire II; adult; Article; assessment of humans; Beck Anxiety Inventory; Beck Depression Inventory; Cognitive Fusion Questionnaire; confirmatory factor analysis; controlled study; diagnostic test accuracy study; Dimensional Obsessive Compulsive Scale; DSM-5; exploratory factor analysis; female; human; major clinical study; male; mental health; obsessive compulsive disorder; Perceived Stress Scale; psychologic assessment; receiver operating characteristic; scoring system; self report; sensitivity and specificity; university student | English | 2024 | 2024-03 | 10.30773/pi.2023.0240 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Impact of Model Resolution and Initial/Boundary Conditions in Forecasting Low-Level Atmospheric Fields over the Incheon International Airport | This study investigates the impact of initial conditions/boundary conditions (ICs/BCs) and horizontal resolutions on forecast for average weather conditions, focusing on low-level weather variables such as 2-m temperature (T2m), 2-m water vapor mixing ratio (Q2m), and 10-m wind speed (WS10). A Weather Research and Forecasting (WRF) Model is used for regional mesoscale model simulations and large-eddy simulations (LESs). The 6-h-interval forecast fi elds generated by the Global Forecast System of the National Centers for Environmental Prediction and the Korean Integrated Model of the Korea Meteorological Administration are utilized as ICs/BCs for the regional models. Numerical experiments are performed for 24 h starting at 0000 UTC on each day in April 2021 when the average monthly wind speed was strongest during 10 years (2011-20). A comparison of model simulations with observations obtained around the Yeongjong Island, where Incheon International Airport is situated, shows that the regional models capture the time series of T2m, Q2m, and WS10 more effectively than the global model forecasts. Moreover, the LES experiments with a 100-m horizontal grid spacing simulate higher Q2m and lower WS10 during the daytime compared to the 1-km WRF. This results in a deterioration of their time-series correlation with the observations. Meanwhile, the 100-m LES forecasts time series of T2m over ocean stations and Q2m over land stations, as well as probability density functions of low-level weather variables, more accurately than that of the 1-km WRF. Our study also emphasizes the need for caution when comparing high-resolution model results with observation values at specific fi c stations due to the high spatial variability in low-level meteorological fi elds. | Do, Yujeong; Lim, Kyo-Sun Sunny; Kim, Ki-Byung; Shin, Hyeyum Hailey; Chang, Eun-Chul; Lee, Gyuwon | Kyungpook Natl Univ, Ctr Atmospher Remote Sensing, Dept Atmospher Sci, BK21 Weather Extremes Educ & Res Team, Daegu, South Korea; Natl Ctr Atmospher Res, Boulder, CO USA; Kongju Natl Univ, Dept Atmospher Sci, Gongju, South Korea | Lim, Kyo-Sun/I-3811-2012 | 59309238200; 57211926026; 57744911000; 54992767300; 55626446400; 7404852271 | kyosunlim@knu.ac.kr; | JOURNAL OF APPLIED METEOROLOGY AND CLIMATOLOGY | J APPL METEOROL CLIM | 1558-8424 | 1558-8432 | 63 | 8 | SCIE | METEOROLOGY & ATMOSPHERIC SCIENCES | 2024 | 2.2 | 63.5 | 0 | 2025-05-07 | 0 | 0 | Numerical weather prediction/forecasting; Model comparison; Model evaluation/performance; Large eddy simulations; Boundary conditions | SURFACE WIND; AIR-QUALITY; WRF; WEATHER; REPRESENTATION; SIMULATIONS; SYSTEM; FOG | Boundary conditions; Large eddy simulations; Model comparison; Model evaluation/performance; Numerical weather prediction/forecasting | Incheon [South Korea]; South Korea; Prediction models; Wind effects; Wind forecasting; Condition; Incheon International Airport; Initial conditions; Large-eddy simulations; Model evaluation/performance; Models comparisons; Numerical weather prediction/forecasting; Regional modelling; Times series; Wind speed; air temperature; airport; boundary condition; climate prediction; comparative study; large eddy simulation; mixing ratio; numerical model; spatial variation; water vapor; weather forecasting; wind velocity; Weather forecasting | English | 2024 | 2024-08 | 10.1175/jamc-d-24-0011.1 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Acetylcholinesterase inhibition studies of alkaloid components from Crinum asiaticum var. sinicum: in vitro assessments by molecular docking and molecular dynamics simulations | Alkaloids are among the most important and best-known secondary metabolites as sources of new drugs from medicinal plants and marine organisms. A phytochemical investigation of the whole plant of Crinum asiaticum var. sinicum resulted in the isolation of seven alkaloids (1-7), including one new dimeric compound, bis-(-)-8-demethylmaritidine (1). Their structures were elucidated using NMR and HR-ESI-MS. The absolute configuration of new compound 1 was established by circular dichroism spectroscopy. All isolated compounds were evaluated for their inhibitory effects on acetylcholinesterase (AChE) activity in vitro. Among them, compound 1 exhibited the most potent AChE inhibition. Moreover, molecular docking and molecular dynamics simulations were carried out for the most active compound to investigate their binding interactions and dynamics behavior of the AChE protein-ligand complex. Therefore, compound 1 may be a potential candidate for effectively treating Alzheimer's disease. | Duc, Ngo Viet; Trang, Vu Thi; Tuan Anh, Hoang Le; Vinh, Le Ba; Phong, Nguyen Viet; Thuan, Tran Quang; Hieu, Ngo Van; Dat, Nguyen Tien; Nhan, Le Van; Tuan, Do Thanh; Tuan Anh, Le; Thao, Do Thi; Tai, Bui Huu; Cuong, Nguyen Cao; Lien, Le Quynh; Yang, Seo Young | Vietnam Acad Sci & Technol VAST, Ctr Res & Technol Transfer CRTT, Hanoi 10072, Vietnam; Grad Univ Sci & Technol, VAST, Hanoi 10072, Vietnam; Kyungpook Natl Univ, Teachers Coll, Dept Biol Educ, Daegu 41566, South Korea; Kyungpook Natl Univ, Inst Phylogen & Evolut, Daegu 41566, South Korea; VAST, Inst Marine Biochem, Hanoi 10072, Vietnam; Hanoi Univ Ind, Fac Chem Technol, Hanoi 11900, Vietnam; ThaiBinh Univ Med & Pharm, Thai Binh 06100, Vietnam; VAST, VNMN, Mientrung Inst Sci Res, Hanoi 10072, Vietnam; VAST, Inst Biotechnol, Hanoi 10072, Vietnam; Yersin Univ, Dept Med & Pharm, Da Lat 66100, Vietnam; Vietnam Acad Sci & Technol VAST, Inst Marine Biochem, 18 Hoang Quoc Viet, Hanoi 10072, Vietnam; Kyungpook Natl Univ, Teachers Coll, Dept Biol Educ, Daegu 41566, South Korea; Kyungpook Natl Univ, Inst Phylogen & Evolut, Daegu 41566, South Korea | Tai, Bui/S-1021-2017; Le, Vinh/AAK-7699-2021; Nguyen, Viet Phong/AAQ-4207-2021; Ngo, Viet/E-8925-2019 | 55883758600; 57194563620; 36458092600; 57190582257; 57205196739; 58135162300; 58664961500; 6602889201; 58665165500; 57191259970; 58138710400; 56677371200; 34772017200; 58665361000; 55644103700; 57215036954 | syy@knu.ac.kr;lienle@vast.gov.vn; | JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | J ASIAN NAT PROD RES | 1028-6020 | 1477-2213 | 26 | 5 | SCIE | CHEMISTRY, APPLIED;CHEMISTRY, MEDICINAL;PHARMACOLOGY & PHARMACY;PLANT SCIENCES | 2024 | 1.3 | 63.6 | 1.14 | 2025-04-16 | 4 | 3 | Crinum asiaticum var. sinicum; alkaloid; acetylcholinesterase inhibitor; protein-ligand complex; Alzheimer's disease | CHEMICAL-CONSTITUENTS | acetylcholinesterase inhibitor; alkaloid; Alzheimer’s disease; Crinum asiaticum var. sinicum; protein-ligand complex | Acetylcholinesterase; Alkaloids; Cholinesterase Inhibitors; Crinum; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; acetylcholinesterase; alkaloid; bis 8 demethylmaritidine; cholinesterase inhibitor; unclassified drug; acetylcholinesterase; alkaloid; cholinesterase inhibitor; Article; carbon nuclear magnetic resonance; circular dichroism; controlled study; Crinum; Crinum asiaticum var. sinicum; drug isolation; drug potency; drug protein binding; drug structure; electrospray mass spectrometry; enzyme inhibition; hydrogen bond; IC50; in vitro study; molecular docking; molecular dynamics; proton nuclear magnetic resonance; chemical structure; chemistry; drug effect; metabolism | English | 2024 | 2024-05-03 | 10.1080/10286020.2023.2269541 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Improvement of severe alopecia areata in an adolescent patient on upadacitinib | Recently, alopecia areata (AA) treatment via the Janus kinase (JAK)-signal transducer and activator of transcription pathway has been reported. However, as baricitinib, a JAK1/2 inhibitor is only approved for adult patients, children, and adolescent patients still lack treatment options. We present a case that showed improvement of severe AA in an adolescent patient on upadacitinib, which has been approved by the Food and Drug Administration (FDA) for use in patients with rheumatoid disease or atopic dermatitis (AD) in children aged 12 years or older and weighing 40 kg or more. Herein, we suggest that upadacitinib can be a good alternative for adolescent patients with AA, particularly those who may also have AD. | Ha, Gi Ung; Kim, Jin Ho; Jang, Yong Hyun | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Dermatol, Daegu, South Korea; Kyungpook Natl Univ Hosp, Dept Dermatol, 130 Dongdeok Ro, Daegu 41944, South Korea | 57783275400; 58508499500; 57016046400 | yhjang@knu.ac.kr; | PEDIATRIC DERMATOLOGY | PEDIATR DERMATOL | 0736-8046 | 1525-1470 | 41 | 2 | SCIE | DERMATOLOGY;PEDIATRICS | 2024 | 1.2 | 63.6 | 9.42 | 2025-05-07 | 6 | 6 | adolescent; alopecia areata; upadacitinib | adolescent; alopecia areata; upadacitinib | Adolescent; Adult; Alopecia Areata; Child; Diffuse alopecia; Heterocyclic Compounds, 3-Ring; Humans; Janus Kinase Inhibitors; Janus Kinases; United States; corticosteroid; cyclosporine; diphencyprone; minoxidil; upadacitinib; fused heterocyclic rings; Janus kinase; Janus kinase inhibitor; upadacitinib; adolescent; alopecia areata; atopic dermatitis; case report; clinical article; cryotherapy; disease severity; eyebrow; female; human; laser therapy; Letter; medical history; scalp; systemic therapy; adult; alopecia; alopecia areata; child; metabolism; United States | English | 2024 | 2024-03 | 10.1111/pde.15504 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Cretaceous beetles from Jinju Formation: Trachypachidae (Coleoptera: Adephaga) | Here we describe two new species, Psacodromeus recta sp. nov. and Necronectulus lazarus sp. nov., that belong to the family Trachypachidae. Only one species of the genus Psacodromeus, P. minor, was reported from the Gurvaneren Formation in Mongolia, which is estimated as Early Cretaceous. Other species of the genus Psacodromeus, including P. crassus, P. gutta, P. ovalis, and P. rugosus, were reported from the Karabastau Formation in Kazakhstan, which is dated to the Late Jurassic. Necronectulus avus, which is the only species of the genus Necronectulus, was reported from the Tologoi Formation in Kazakhstan, which is dated to the Late Triassic. Therefore, our study has expanded the fossil record of the genera Psacodromeus and Necronectulus from the Early Cretaceous. | BIN Lee, Soo; Nam, Gi soo; Park, Jong kyun | Korean Fossil Res Ctr, 50-2 Hangangro 2Ga, Seoul, South Korea; Gongju Natl Univ Educ, Dept Sci Educ, 27 Ungjinro, Gongju Si 32553, Chungcheonnam D, South Korea; Kyungpook Natl Univ, Coll Ecol & Environm Sci, Sangju Si 37224, Gyeongsangbuk D, South Korea | 57809940200; 57212227602; 37661967000 | dinos20000@naver.com;fossil@gjue.ac.kr;entopark@knu.ac.kr; | ZOOTAXA | ZOOTAXA | 1175-5326 | 1175-5334 | 5562 | 1 | SCIE | ZOOLOGY | 2024 | 0.9 | 63.8 | 0 | 2025-05-07 | 0 | 0 | Trachypachidae; Early Cretaceous; Jinju Formation; South Korea | GYEONGSANG BASIN; KOREA; INSECTA; DEPOSITS; GENUS | Early Cretaceous; Jinju Formation; South Korea; Trachypachidae | Animal Distribution; Animal Structures; Animals; Body Size; Coleoptera; Female; Fossils; Kazakhstan; Male; Mongolia; Organ Size; animal; animal dispersal; animal structures; beetle; body size; classification; female; fossil; growth, development and aging; Kazakhstan; male; Mongolia; organ size | English | 2024 | 2024-12-31 | 10.11646/zootaxa.5562.1.12 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Review of the ground beetle subgenus Micronialoe from Korea, with a description of a new species (Coleoptera: Carabidae: Pterostichus) | Micronialoe (Pterostichini: Pterostichus) is a poorly known subgenus of the ground beetle genus Pterostichus, which includes three species from the Korean Peninsula and adjacent islands. Here, a new species, Pterostichus (Micronialoe) spinulosus sp. nov., was identified among the specimens collected from Mt. Biseulsan and Mt. Choejeongsan, Daegusi, Korea. Along with the description of the new species, all Korean species are redescribed, and the subgenus is re- diagnosed. The new species is morphologically allied to P. (M.) bifoveolatus, thus, the intraspecific variation of the new species is examined and valid characters for distinguishing species are discussed. A key for the identification of the species of the subgenus is also provided. | Kim, Dooyoung; Suh, Sang jae | Kyungpook Natl Univ, Sch Ind Technol Adv, Dept Biomed Convergence Sci & Technol, Daegu, South Korea; Kyungpook Natl Univ, Dept Plant Med, Daegu, South Korea; Kyungpook Natl Univ, Inst Plant Med, Daegu 41566, South Korea | 57759300300; 15754843200 | dooyoung11@gmail.com;sjsuh@knu.ac.kr; | ZOOTAXA | ZOOTAXA | 1175-5326 | 1175-5334 | 5471 | 4 | SCIE | ZOOLOGY | 2024 | 0.9 | 63.8 | 0 | 2025-05-07 | 0 | 0 | Pterostichini; morphology; taxonomy; intraspecific variation | GENUS PTEROSTICHUS | intraspecific variation; morphology; Pterostichini; taxonomy | Animal Distribution; Animal Structures; Animals; Body Size; Coleoptera; Female; Male; Organ Size; Republic of Korea; animal; animal dispersal; animal structures; beetle; body size; classification; female; growth, development and aging; male; organ size; South Korea | English | 2024 | 2024-06-20 | 10.11646/zootaxa.5471.4.4 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Synthesis, characterization, in silico and in vitro studies of novel glycoconjugates as potential antibacterial, antifungal, and antileishmanial agents | In the present work, several new glycoconjugates (8a-e) were generated from glycopyranosyl-alpha-trichloroacetimidates (sugar-OTCA) as glycosyl donors and dimethyl-l-tartrate as an aglycone acceptor in good to excellent yields. In the synthetic protocol, various monosaccharides were transformed into pentaacetylated derivatives and then into glycopyranosyl-alpha-trichloroacetimidates. Afterward, the sugar-OTCA was reacted with dimethyl-l-tartrate using Schmidt's trichloroacetimidate protocol to give the desired products. The newly synthesized glycoconjugates were characterized by FT-IR, H-1, and C-13-NMR spectroscopic analytical methods. All the target compounds (8a-e) were tested in vitro against various strains of bacteria and fungi at different concentrations. The results revealed that the target compounds had encouraging antibacterial and antifungal potential. The antileishmanial activity of the target compounds against Leishmania tropica promastigotes was also investigated. The in vitro results were further supported by the in silico docking study that indicated minimum values of the docking scores and binding energies for the resulting complexes obtained by the favorable interactions between the target compounds (8a-e) and the selected strains of bacteria and fungi. The docking results proposed promising antibacterial and antifungal activities of the target compounds (8a-e) against the selected bacterial and fungal species. | Khan, Sher Wali; Nayab, Saira; Umar, Muhammad Naveed; Khan, Momin; Iqbal, Anila; Ahmad, Nasir; Rashid, Haroon Ur; Shah, Muhammad Ishaq Ali; Gulfam, Naila; Zahoor, Muhammad; Ullah, Riaz; Ali, Essam A. | Rawalpindi Women Univ, Dept Chem, 6th Rd Satellite Town, Rawalpindi, Pakistan; Univ Malakand, Dept Biochem, Chakdara Dir Lower, Chakdara 18800, KPK, Pakistan; Shaheed Benazir Bhutto Univ Sheringal, Dept Chem, Khyber Pakhtunkhwa, Pakistan; Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Kyungpook Natl Univ, Green Nano Mat Res Ctr, Daegu 41566, South Korea; Univ Liverpool, Dept Chem, Liverpool, Merseyside, England; Univ Malakand, Dept Chem, Chakdara 181800, KPK, Pakistan; Khyber Med Univ, Inst Pathol & Diag Med IPDM, Peshawar, KP, Pakistan; Quaid i Azam Univ, Natl Ctr Phys NCP, Islamabad 45320, Pakistan; Univ Fed Pelotas, Ctr Chem Pharmaceut & Food Sci, Pelotas, RS, Brazil; Abdul Wali Khan Univ, Dept Chem, Mardan, Pakistan; Univ Peshawar, Dept Zool, Jinnah Coll Women, Peshawar, Khyber Pakhtunk, Pakistan; King Saud Univ, Dept Pharmacognosy, Coll Pharm, Riyadh 11451, Saudi Arabia; King Saud Univ, Dept Pharmaceut Chem, Coll Pharm, Riyadh, Saudi Arabia | Rashid, Haroon/G-1326-2014; Nayab, Saira/W-3063-2019; Ali, essam/AEA-0753-2022; Zahoor, Muhammad/AFN-2277-2022; Ali, Essam/ADF-1206-2022 | 55509048900; 36490286400; 59453120900; 35484504700; 57190582382; 59532433600; 7102095351; 57201184540; 57194438807; 26434535400; 35748224100; 57384929100 | sherwalikhan@f.rwu.edu.pk;m.naveed-umar@liverpool.ac.uk;mominkhan.ibms@kmu.edu.pk;a.anilaiqbal@gmail.com;nasirdft@gmail.com;haroongold@gmail.com;ishaqalishah@awkum.edu.pk;nailazoo@uop.edu.pk;mohammadzahoorus@yahoo.com;rullah@ksu.edu.sa;esali@ksu.edu.sa; | OPEN CHEMISTRY | OPEN CHEM | 2391-5420 | 22 | 1 | SCIE | CHEMISTRY, MULTIDISCIPLINARY | 2024 | 1.9 | 63.8 | 0 | 2025-04-16 | 1 | 2 | glycoconjugates; glycopyranosyl-alpha-trichloroacetimidates; glycosylation; antimicrobial; antileishmanial; molecular docking | TRICHLOROACETIMIDATE METHOD; ACTIVATION; SPECIFICITY; INHIBITORS; BINDING; ENZYME | antileishmanial; antimicrobial; glycoconjugates; glycopyranosyl-α-trichloroacetimidates; glycosylation; molecular docking | English | 2024 | 2024-02-13 | 10.1515/chem-2023-0195 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Cerebellar Nuclei Receiving Orofacial Proprioceptive Signals through the Mossy Fiber Pathway from the Supratrigeminal Nucleus in Rats | Proprioception from muscle spindles is necessary for motor function executed by the cerebellum. In particular, cerebellar nuclear neurons that receive proprioceptive signals and send projections to the lower brainstem or spinal cord play key roles in motor control. However, little is known about which cerebellar nuclear regions receive orofacial proprioception. Here, we investigated projections to the cerebellar nuclei from the supratrigeminal nucleus (Su5), which conveys the orofacial proprioception arising from jaw-closing muscle spindles (JCMSs). Injections of an anterograde tracer into the Su5 resulted in a large number of labeled axon terminals bilaterally in the dorsolateral hump (IntDL) of the cerebellar interposed nucleus (Int) and the dorsolateral protuberance (MedDL) of the cerebellar medial nucleus. In addition, a moderate number of axon terminals were ipsilaterally labeled in the vestibular group Y nucleus (group Y). We electrophysiologically detected JCMS proprioceptive signals in the IntDL and MedDL. Retrograde tracing analysis confirmed bilateral projections from the Su5 to the IntDL and MedDL. Furthermore, anterograde tracer injections into the external cuneate nucleus (ECu), which receives other proprioceptive input from forelimb/neck muscles, resulted in only a limited number of ipsilaterally labeled terminals, mainly in the dorsomedial crest of the Int and the group Y. Taken together, the Su5 and ECu axons almost separately terminated in the cerebellar nuclei (except for partial overlap in the group Y). These data suggest that orofacial proprioception is differently processed in the cerebellar circuits in comparison to other body-part proprioception, thus contributing to the executive function of orofacial motor control. | Tsutsumi, Yumi; Morita, Yayoi; Sato, Fumihiko; Furuta, Takahiro; Uchino, Katsuro; Sohn, Jaerin; Haque, Tahsinul; Bae, Yong Chul; Niwa, Hitoshi; Tachibana, Yoshihisa; Yoshida, Atsushi | Osaka Univ, Dept Systemat Anat & Neurobiol, Grad Sch Dent, 1-8 Yamadaoka, Suita, Osaka 5650871, Japan; Osaka Univ, Grad Sch Dent, Dept Dent Anesthesiol, Suita, Osaka 5650871, Japan; Takarazuka Univ Med & Hlth Care, Fac Hlth Care Sci, Dept Acupuncture, Takarazuka, Hyogo 6660162, Japan; Dar Al Uloom Univ, Coll Dent, Dept Prevent Sci, Riyadh 13314, Saudi Arabia; Kyungpook Natl Univ, Sch Dent, Dept Anat & Neurobiol, Daegu 41940, South Korea; Kobe Univ, Div Physiol & Cell Biol, Grad Sch Med, 7-5-1 Kusunoki, Kobe, Hyogo 6500017, Japan; Takarazuka Univ Med & Hlth Care, Fac Hlth Care Sci, Dept Oral Hlth Sci, Takarazuka, Hyogo 6660162, Japan | Haque, Tahsinul/KUC-7054-2024; Haque, Md/KUC-7054-2024 | 57196150893; 57284206500; 37112998700; 7201372674; 35742156800; 39863626400; 26537402900; 56377838800; 24351577000; 47461520500; 55757780066 | yoshi@med.kobe-u.ac.jp;yoshida.atsushi.dent@osaka-u.ac.jp; | CEREBELLUM | CEREBELLUM | 1473-4222 | 1473-4230 | 23 | 5 | SCIE | NEUROSCIENCES | 2024 | 2.4 | 63.9 | 0.62 | 2025-05-07 | 2 | 2 | Precerebellar neurons; Muscle spindle; Deep sensation; Trigeminal; Tract tracing | RETICULARIS-TEGMENTI PONTIS; MUSCLE-SPINDLE AFFERENTS; EXTERNAL CUNEATE NUCLEI; GROUP Y NUCLEUS; INTERPOSITUS NEURONS; HORSERADISH-PEROXIDASE; PROJECTION PATTERNS; MASSETER MUSCLE; TACTILE AREAS; BRAIN-STEM | Deep sensation; Muscle spindle; Precerebellar neurons; Tract tracing; Trigeminal | Animals; Cerebellar Nuclei; Facial Muscles; Male; Muscle Spindles; Neural Pathways; Proprioception; Rats; Rats, Wistar; tracer; animal experiment; animal model; animal tissue; Article; axon; cerebellar mossy fiber; cerebellum nucleus; controlled study; cuneate nucleus; face pain; forelimb; interpositus nucleus; jaw; jaw closing muscle spindle; male; muscle spindle; neck muscle; nerve ending; nervous system electrophysiology; nonhuman; proprioception; rat; supratrigeminal nucleus; trigeminal nucleus; vestibular system; animal; face muscle; innervation; nerve tract; physiology; Wistar rat | English | 2024 | 2024-10 | 10.1007/s12311-023-01602-9 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | DROPLET SIZE DISTRIBUTION VARIATION OF PENDENT FIRE SPRINKLER SPRAY DEPENDING ON THE MEASUREMENT LOCATION | Droplet size of sprinkler sprays is related to the rate of evaporation and penetration of a fire plume. However, sprinkler sprays have various droplet sizes even at one location. Therefore, it is essential to examine the droplet size distribution depending on the location to predict the fire suppression performance of the sprinkler spray. To examine the droplet size distribution of spray from a pendent sprinkler head, acrylic plates were installed around the sprinkler head and a gap was made on one side of the wall. A charge-coupled device camera was installed to capture the droplet images both on a plane parallel to the sprinkler frame arm and on a plane perpendicular to the frame arm. Droplet information was obtained by deriving the image from the brightness and gradient images extracted from the original image. Large droplets, exceeding 1.5 mm in diameter, were observed in the mainstream of the spray. The probability of observing small droplets decreased as the droplets moved downstream. Spherical droplets were observed in the mainstream of the frame arm direction, while nonspherical droplets were observed in the perpendicular direction to the frame arm because of high velocity. The number-based cumulative distribution function (CDFs) fitted using the Rosin-Rammler distribution function provided the best fitting results. The volume CDFs fitted using the Rosin-Rammler distribution function yielded acceptable adjusted R-2 values. In this case, the coefficient m related to D-v50 and the coefficient n related to the width of the distribution increased with increasing radial and vertical locations. | Song, Jingeun; Kim, Taehoon | Kyungpook Natl Univ, Sch Automot Engn, 2559 Gyeongsang Daero, Sangju Si 37224, Gyeongsangbukdo, South Korea; Seoul Natl Univ Sci & Technol, Dept Safety Engn, 232 Gongneung Ro, Seoul 01811, South Korea | Song, Jingeun/MTG-2604-2025; Kim, Taehoon/ABF-7433-2021 | 56714139600; 55763792411 | tkim@seoultech.ac.kr; | ATOMIZATION AND SPRAYS | ATOMIZATION SPRAY | 1044-5110 | 1936-2684 | 34 | 6 | SCIE | ENGINEERING, CHEMICAL;ENGINEERING, MECHANICAL;ENGINEERING, MULTIDISCIPLINARY;MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED | 2024 | 0.9 | 64.3 | 0 | 2025-04-16 | 0 | 0 | droplet size distribution; fire safety; fire sprinkler; imaging method; analysis; Rosin-Rammler distribution | droplet size distribution; fire safety; fire sprinkler; imaging method analysis; Rosin–Rammler distribution | Charge coupled devices; Distribution functions; Fires; Image processing; Location; Size distribution; A-plane; Cumulative distribution function; Droplet size distributions; Droplets sizes; Fire safety; Fire sprinklers; Imaging method; Imaging method analyse; Method analysis; Rosin–rammle distribution; CCD cameras | English | 2024 | 2024 | 10.1615/atomizspr.2024048168 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Immune Boosting Effect of Limosilactobacillus Reuteri in Immunocompetent C57BL/6J Mice | Probiotics are well-known to be directly or indirectly involved in the host immune system. In this study, we analyzed the immune-boosting effects of lactic acid bacteria, including Limosilactobacillus and Lactococcus, in immunocompetent C57BL/6J mice. Three different lactic acid bacteria strains were orally administered to C57BL/6J mice for 8 weeks. Then, liver, spleen, and whole blood were harvested after sacrificing the animals. There were no significant changes in whole-body weight, weight of organs, or complete blood cell count by oral administration of lactic acid bacteria. The frequencies of CD3(+), CD4(+), and CD8(+) T cells were significantly increased in the Limosilactobacillus reuteri MG5462 group compared to control. The frequency of NK1.1(+) cells was significantly increased in the Lactococcus lactis MG5474 group compared to control. On the other hand, splenocyte proliferations and natural killer cytotoxicity did not differ between groups. In addition, the MG5462 group had a significant increase in the production of TNF-alpha compared to the control, which is consistent with the upregulation of T cells in the MG5462 group. Therefore, Limosilactobacillus reuteri could be a functional food additive to boost immunity by positively affecting T cell populations. | Jung, Hyunna; Lee, Hwan Hee; Kang, Hyojeung; Cho, Hyosun | Duksung Womens Univ, Coll Pharm, Seoul 01369, South Korea; Kyungpook Natl Univ, Coll Pharm, Daegu, South Korea | 58029383500; 56271051000; 8979751700; 55572361200 | hkang72@knu.ac.kr;hyosun1102@duksung.ac.kr; | JOURNAL OF MEDICINAL FOOD | J MED FOOD | 1096-620X | 1557-7600 | 27 | 8 | SCIE | CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY;NUTRITION & DIETETICS | 2024 | 2 | 64.4 | 0.69 | 2025-05-07 | 1 | 1 | limosilactobacillus reuteri; immune-boosting; immunocompetent animal | immune-boosting; immunocompetent animal; limosilactobacillus reuteri | Animals; CD8-Positive T-Lymphocytes; Killer Cells, Natural; Limosilactobacillus reuteri; Liver; Male; Mice; Mice, Inbred C57BL; Probiotics; Spleen; T-Lymphocytes; Tumor Necrosis Factor-alpha; lactic acid; probiotic agent; probiotic agent; tumor necrosis factor; animal cell; animal experiment; animal model; Article; bacterial strain; blood cell count; blood sampling; body weight; C57BL 6 mouse; CD3+ T lymphocyte; CD4+ T lymphocyte; CD8+ T lymphocyte; cell proliferation; controlled study; cytotoxicity; immunity; immunocompetence; lactic acid bacterium; Lactobacillus reuteri; Lactococcus; Lactococcus lactis; Limosilactobacillus; liver; liver weight; male; mouse; nonhuman; spleen; spleen cell; spleen weight; animal; C57BL mouse; cytology; immunology; metabolism; natural killer cell; spleen; T lymphocyte | English | 2024 | 2024-08-01 | 10.1089/jmf.2024.k.0085 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | In Vitro and In Vivo Models for the Development of Hair Growth Materials By Regulating the β-Catenin Signaling Pathways | Although hair loss contributes to various social and economic, research methods for material development are currently limited. In this study, we established a research model for developing materials for hair growth through the regulation of beta-catenin. We confirmed that 100 nM tegatrabetan (TG), a beta-catenin inhibitor, decreased the proliferation of human hair follicle dermal papilla cells (HFDPCs) at 72 h. In addition, TG-induced apoptosis suppressed the phosphorylation of GSK-3 beta and Akt, translocation of beta-catenin from the cytosol to the nucleus, and the expression of cyclin D1. Interestingly, TG significantly increased the G2/M arrest in HFDPCs. Subcutaneous injection of TG suppressed hair growth and the number of hair follicles in C57BL/6 mice. Moreover, TG inhibited the expression of cyclin D1, beta-catenin, keratin 14, and Ki67. These results suggest that TG-induced inhibition of hair growth can be a promising model for developing new materials for enhancing beta-catenin-mediated hair growth. | Woo, Min Jeong; Choi, Jeongin; Kang, Ha Yeong; Jang, Sehyeon; Kim, Min Jeong; Kim, Seahyun; Byun, Sanguine; Jung, Sung Keun | Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu, South Korea; Nong Shim Co Ltd, Res & Dev Ctr, Seoul, South Korea; Yonsei Univ, Dept Bioind Engn, Seoul, South Korea; Yonsei Univ, Dept Biotechnol, Seoul, South Korea; Kyungpook Natl Univ, Res Inst Tailored Food Technol, Daegu, South Korea; Yonsei Univ, Dept Biotechnol, Seoul 03722, South Korea; Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea | Jung, SUNG KEUN/AGR-2623-2022; Byun, Sanguine/AAR-5451-2021 | 58028839700; 58938880300; 57733176700; 58142092600; 57215818497; 58937606200; 24490630000; 35310491400 | sanguine@yonsei.ac.kr;skjung04@knu.ac.kr; | JOURNAL OF MEDICINAL FOOD | J MED FOOD | 1096-620X | 1557-7600 | 27 | 5 | SCIE | CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY;NUTRITION & DIETETICS | 2024 | 2 | 64.4 | 0.69 | 2025-05-07 | 1 | 1 | alopecia; hair growth; beta-catenin; tegatrabetan; cell cycle | FOLLICLE MORPHOGENESIS; APOPTOSIS; CXXC5 | alopecia; cell cycle; hair growth; tegatrabetan; β-catenin | Animals; Apoptosis; beta Catenin; Cell Proliferation; Cyclin D1; Glycogen Synthase Kinase 3 beta; Hair; Hair Follicle; Humans; Male; Mice; Mice, Inbred C57BL; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction; beta catenin; cyclin D1; cyclin D3; cyclin dependent kinase 6; cycline; cytochrome c; cytokeratin 14; eosin; glycogen synthase kinase 3beta; growth inhibitor; hematoxylin; Ki 67 antigen; loricrin; protein Bax; protein bcl 2; protein inhibitor; protein kinase B; protein p21; reactive oxygen metabolite; tegatrabetan; testosterone; unclassified drug; beta catenin; cyclin D1; glycogen synthase kinase 3beta; protein kinase B; animal cell; animal experiment; animal model; animal tissue; apoptosis; Article; C57BL 6 mouse; canonical Wnt signaling; cell proliferation; cell proliferation assay; controlled study; enzyme phosphorylation; flow cytometry; frozen section; G2 phase cell cycle checkpoint; hair follicle; hair follicle cell; hair growth; hair loss; hair removal; human; human cell; immunofluorescence assay; in vitro study; in vivo study; male; mouse; nonhuman; papillary dermis; Western blotting; animal; C57BL mouse; cell proliferation; drug effect; genetics; growth, development and aging; hair; hair follicle; metabolism; phosphorylation; signal transduction | English | 2024 | 2024-05-01 | 10.1089/jmf.2023.k.0258 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Korean Red Ginseng Extract Powder Mitigates Fasting And Postprandial Hyperglycemia in Type 2 Diabetic Mice | Type 2 diabetes mellitus (T2DM) involves insulin resistance and elevated blood sugar levels, causing complications. Red ginseng extract powder (RGEP) from Panax ginseng Meyer shows promise for diabetes treatment. However, its efficacy in managing T2DM remains unclear. Therefore, this study aims to evaluate the effectiveness of RGEP in a mouse model of T2DM. The efficacy of RGEP in treating T2DM was assessed in db/db mice. Mice were divided into seven groups: control, db/db, metformin, and RGEP at 50, 100, 200, and 400 mg/kg. Administered orally for 9 weeks, RGEP effects on glucose regulation and insulin sensitivity were assessed through various metabolic parameters. In addition, mRNA expression levels of genes associated with hepatic gluconeogenesis and insulin sensitivity were examined. Fasting blood sugar showed a significant decrease in all RGEP concentration groups, but OGTT and insulin tolerance test showed a significant decrease at the RGEP concentration of 400 mg/kg, indicating enhanced glycemic control. Moreover, RGEP dose-dependently decreased serum glucose, HbA1c levels, and homeostatic model assessment of insulin resistance values, suggesting its effectiveness in reducing insulin resistance in db/db mice. Furthermore, RGEP downregulated mRNA expression of key components in the gluconeogenesis pathway (G6Pase, FOXO1, GLUT4, and PEPCK), insulin sensitivity (leptin, insulin1, PTP1B, GLP-1, and DPP-4), and mitochondria energy metabolism (PGC1) in either the liver or pancreas, while simultaneously upregulating GLP-1 expression. In conclusion, these findings highlight the potential of RGEP as a complementary therapy for T2DM, indicating therapeutic efficacy in managing diabetic complications through improved metabolic parameters. | Jo, Min-Jeong; Hwang, Sun Jin; Kwon, Han-Ol; Kim, Jong-Han; Shim, Sung Lye; Park, Sang-Joon | Kyungpook Natl Univ, Coll Vet Med, Dept Histol, Daegu 41566, South Korea; Korea Ginseng Corp, Korea Ginseng Corp Res Inst, Gwacheon, South Korea | Kim, Jonghan/AAH-9562-2021 | 57223119334; 59331679500; 56988357600; 57216274059; 57221761354; 7501825941 | psj26@knu.ac.kr; | JOURNAL OF MEDICINAL FOOD | J MED FOOD | 1096-620X | 1557-7600 | 27 | 11 | SCIE | CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY;NUTRITION & DIETETICS | 2024 | 2 | 64.4 | 0 | 2025-05-07 | 0 | 0 | fasting blood glucose; insulin resistance; insulin sensitivity; postprandial hyperglycemia; red ginseng extract powder; type 2 diabetes mellitus | PANAX-QUINQUEFOLIUS L.; INSULIN SENSITIVITY; OXIDATIVE STRESS; GLUCOSE-UPTAKE; MELLITUS; HYPOGLYCEMIA; GINSENOSIDES; RESISTANCE; MORTALITY; PATHWAY | fasting blood glucose; insulin resistance; insulin sensitivity; postprandial hyperglycemia; red ginseng extract powder; type 2 diabetes mellitus | Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Fasting; Gluconeogenesis; Humans; Hyperglycemia; Hypoglycemic Agents; Insulin; Insulin Resistance; Liver; Male; Mice; Mice, Inbred C57BL; Panax; Plant Extracts; Postprandial Period; Powders; antidiabetic agent; dipeptidyl peptidase IV; ginseng extract; glucagon like peptide 1; glucose; glucose 6 phosphatase; glucose transporter 4; hemoglobin A1c; insulin; leptin; metformin; phosphoenolpyruvate carboxylase; protein tyrosine phosphatase 1B; red ginseng extract powder; transcription factor FKHR; unclassified drug; antidiabetic agent; insulin; plant extract; animal experiment; animal model; animal tissue; antidiabetic activity; Article; controlled study; dose response; down regulation; drug efficacy; drug megadose; energy metabolism; fasting; fasting blood glucose level; gluconeogenesis; glycemic control; homeostasis model assessment; insulin sensitivity; insulin tolerance test; liver metabolism; male; metabolic parameters; mitochondrial respiration; mouse; mRNA expression level; non insulin dependent diabetes mellitus; nonhuman; oral glucose tolerance test; pancreas; postprandial hyperglycemia; protein expression; upregulation; animal; blood; C57BL mouse; chemistry; drug effect; drug therapy; experimental diabetes mellitus; gluconeogenesis; glucose blood level; human; hyperglycemia; insulin resistance; liver; metabolism; non insulin dependent diabetes mellitus; Panax; postprandial state; powder | English | 2024 | 2024-11-01 | 10.1089/jmf.2024.k.0179 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Recovery Effects of Nephelium lappaceum var. pallens (Hiern) Leenh. Extract on Testosterone-Induced Inhibition of Hair Growth in C57BL/6 Mice and Human Follicular Dermal Papilla Cells | Although various hair health medicines have been developed and are used today, additional safe and effective natural hair growth therapies still need to be developed. Nephelium lappaceum var. pallens (Hiern) Leenh. extract (NLE) reportedly exhibits anticancer, antidiabetic, and antioxidant effects, which could be linked to androgenic processes; however, there are no reports of its effects on testosterone (TS)-inhibited hair growth. The present study investigated the effects of NLE on TS-induced inhibition of hair growth in C57BL/6 mice and human follicular dermal papilla cells. Oral administration of NLE restored hair growth that was suppressed following subcutaneous injection of TS more effectively than finasteride, a drug used for treating hair loss. Histological analysis demonstrated that oral NLE administration increased the number and diameter of hair follicles in the dorsal skin of C57BL/6 mice. In addition, western blot and immunofluorescence assays showed that the oral NLE administration restored TS-induced suppression of cyclin D1, proliferating cell nuclear antigen, and loricrin expression in the skin cells of the mice. Finally, TS suppression of cell proliferation in human follicular dermal papilla cells was significantly reversed by NLE pretreatment. The results suggest that NLE is a promising nutraceutical for hair growth because it promotes hair growth in androgenetic alopecia-like models. | Kang, Ha Yeong; Woo, Min Jeong; Paik, So Jeong; Choi, Hee Jung; Bach, Tran The; Quang, Bui Hong; Eum, Sang Mi; Paik, Jin-Hyub; Jung, Sung Keun | Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu, South Korea; Vietnam Acad Sci & Technol VAST, Inst Ecol & Biol Resources, Hanoi, Vietnam; Korea Res Inst Biosci & Biotechnol, Int Biol Mat Res Ctr, Daejeon, South Korea; Kyungpook Natl Univ, Res Inst Tailored Food Technol, Daegu, South Korea; Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea | Jung, SUNG KEUN/AGR-2623-2022 | 57733176700; 58028839700; 58161897900; 58742906900; 35083068900; 55260372100; 57190213767; 56530211700; 35310491400 | skjung04@knu.ac.kr; | JOURNAL OF MEDICINAL FOOD | J MED FOOD | 1096-620X | 1557-7600 | 27 | 2 | SCIE | CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY;NUTRITION & DIETETICS | 2024 | 2 | 64.4 | 0 | 2025-05-07 | 0 | 0 | androgenetic alopecia; Nephelium lappaceum var. pallens (Hiern) Leenh. extract; testosterone; hair growth; human follicular dermal papilla cells | ALOPECIA; ANTIOXIDANT; L. | androgenetic alopecia; hair growth; human follicular dermal papilla cells; Nephelium lappaceum var. pallens (Hiern) Leenh. extract; testosterone | Alopecia; Animals; Cells, Cultured; Hair; Hair Follicle; Humans; Mice; Mice, Inbred C57BL; Sapindaceae; Testosterone; cyclin D1; cycline; dermatological agent; eosin; finasteride; hematoxylin; loricrin; nephelium lappaceum var pallens leenh extract; nutraceutical; plant extract; testosterone; unclassified drug; testosterone; animal experiment; animal model; animal tissue; Article; C57BL 6 mouse; cell proliferation; cell proliferation assay; controlled study; drug effect; follicular dermal papilla cell; hair follicle; hair growth; histology; human; human cell; immunofluorescence assay; in vivo study; male; male type alopecia; mouse; Nephelium lappaceum var pallens leenh; nonhuman; pathogenesis; polyacrylamide gel electrophoresis; protein expression; skin; skin cell; Western blotting; alopecia; animal; C57BL mouse; cell culture; hair; Sapindaceae | English | 2024 | 2024-02-01 | 10.1089/jmf.2023.k.0124 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | The Therapeutic Potential of (+)-Afzelechin for Alleviating Sepsis-Associated Pulmonary Injury | Sepsis-induced acute lung injury (ALI) poses a common and formidable challenge in clinical practice, currently lacking efficacious therapeutic approaches. This study delves into the evaluation of (+)-afzelechin (AZC), a natural compound derived from Bergenia ligulata with a diverse array of properties, encompassing antioxidant, anticancer, antimicrobial, and cardiovascular effects to ascertain its effectiveness and underlying mechanisms in mitigating sepsis-induced ALI through animal experimentation. An ALI mouse model induced by sepsis was established through lipopolysaccharide (LPS) administration, and various analytical techniques, including quantitative real-time polymerase chain reaction, Western blotting, and enzyme-linked immunosorbent assay were employed to gauge inflammatory cytokine levels, lung injury, and associated signaling pathways. The animal experiments revealed that AZC offered safeguards against lung injury induced by LPS while reducing inflammatory cytokine levels in both blood serum and lung tissue. Western blotting experiments revealed AZC's downregulation of the toll-like receptor (TLR)4/NF-kappa B pathway and the upregulation of PI3K/Akt, coupled with inhibition of the Hippo and Rho signaling pathways. These findings underscore AZC's efficacy in ameliorating sepsis-induced ALI by modulating cytokine storms and curtailing inflammation via the regulation of TLR4/NF-kappa B, PI3K/Akt, Hippo, and Rho signaling pathways. This work serves as a foundation for additional exploration into AZC's mechanisms and its potential as a therapy for sepsis-induced ALI. Animals in accordance with Kyungpook National University (IRB No. KNU 2022-174). | Cho, Sanghee; Park, Yun Jin; Kim, Eunjeong; Bae, Jong-Sup | Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, Daegu, South Korea; Kyungpook Natl Univ, Coll Nat Sci, Dept Biol, Daegu, South Korea; Kyungpook Natl Univ, Coll Pharm, 80 Daehak Ro, Daegu 41566, South Korea | 58784915200; 58784741900; 56892981600; 16021543200 | baejs@knu.ac.kr; | JOURNAL OF MEDICINAL FOOD | J MED FOOD | 1096-620X | 1557-7600 | 27 | 1 | SCIE | CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY;NUTRITION & DIETETICS | 2024 | 2 | 64.4 | 1.55 | 2025-04-16 | 2 | 2 | (+)-afzelechin; acute lung injury; Hippo; Rho; sepsis | TOLL-LIKE RECEPTORS; ACTIVATED PROTEIN-C; ACUTE LUNG INJURY; PHOSPHOINOSITIDE 3-KINASE; PATHWAY | (+)-afzelechin; acute lung injury; Hippo; Rho; sepsis | Acute Lung Injury; Animals; Cytokines; Flavonoids; Humans; Lipopolysaccharides; Lung; Mice; NF-kappa B; Phenols; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Sepsis; afzelechin; antiinflammatory agent; dexamethasone; gamma interferon; granulocyte macrophage colony stimulating factor; immunoglobulin enhancer binding protein; interleukin 1beta; interleukin 5; interleukin 6; lipopolysaccharide; phosphatidylinositol 4,5 bisphosphate 3 kinase; plant medicinal product; protein kinase B; Rho factor; sevoflurane; toll like receptor 4; tumor necrosis factor; unclassified drug; YAP signaling protein; afzelechin; cytokine; flavonoid; immunoglobulin enhancer binding protein; lipopolysaccharide; phenol derivative; phosphatidylinositol 3 kinase; protein kinase B; analytic method; animal experiment; animal model; animal tissue; antiinflammatory activity; antimicrobial activity; antineoplastic activity; antioxidant activity; Article; Bergenia ligulata; blood sampling; capillary endothelial cell; cardiovascular effect; cell viability assay; controlled study; cytokine storm; down regulation; drug efficacy; drug mechanism; enzyme linked immunosorbent assay; hippo signaling; inflammation; lung parenchyma; lung wet-dry weight ratio; male; mouse; MTT assay; NF kB signaling; nonhuman; perennial plant; Pi3K/Akt signaling; real time polymerase chain reaction; RNA isolation; Saxifragaceae; sepsis-induced acute lung injury; serum; TLR signaling; upregulation; Western blotting; acute lung injury; animal; complication; genetics; human; lung; metabolism; sepsis | English | 2024 | 2024-01-01 | 10.1089/jmf.2023.k.0228 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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