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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Editorial Material | Real-World Experience of Long-Term Dupilumab Treatment for Atopic Dermatitis in Korea | Lee, Dong Hun; Ko, Hyun Chang; Na, Chan Ho; Roh, Joo Young; Park, Kui Young; Park, Young Lip; Park, Young Min; Park, Chang Ook; Park, Chun Wook; Bae, Youin; Seo, Young-Joon; Son, Sang Wook; Ahn, Jiyoung; Jung, Hye Jung; Yang, Jun-Mo; Won, Chong Hyun; Yoo, Kwang Ho; Lew, Bark Lynn; Lee, Sang Eun; Lee, Sung Yul; Lee, Seung-Chul; Lee, Yang Won; Lee, Ji Hyun; Jang, Yong Hyun; Jeon, Jiehyun; Han, Tae-Young; Cho, Sang Hyun | Seoul Natl Univ, Seoul Natl Univ Hosp, Dept Dermatol, Coll Med, Seoul, South Korea; Pusan Natl Univ, Dept Dermatol, Sch Med, Busan, South Korea; Chosun Univ, Dept Dermatol, Coll Med, Gwangju, South Korea; Gachon Univ, Dept Dermatol, Gil Med Ctr, Sch Med, Incheon, South Korea; Chung Ang Univ, Dept Dermatol, Coll Med, Seoul, South Korea; Soonchunhyang Univ, Dept Dermatol, Bucheon Hosp, Bucheon, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Dept Dermatol, Coll Med, Seoul, South Korea; Yonsei Univ, Cutaneous Biol Res Inst, Severance Hosp, Dept Dermatol,Coll Med, Seoul, South Korea; Hallym Univ, Kangnam Sacred Heart Hosp, Dept Dermatol, Coll Med, Seoul, South Korea; Hallym Univ, Dept Dermatol, Dongtan Sacred Heart Hosp, Hwaseong, South Korea; Chungnam Natl Univ, Sch Med, Dept Dermatol, Daejeon, South Korea; Korea Univ, Ansan Hosp, Dept Dermatol, Coll Med, Ansan, South Korea; Natl Med Ctr, Dept Dermatol, Seoul, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Dermatol, Sch Med, Seoul, South Korea; Univ Ulsan, Asan Med Ctr, Dept Dermatol, Coll Med, Seoul, South Korea; Kyung Hee Univ, Dept Dermatol, Coll Med, Seoul, South Korea; Yonsei Univ, Cutaneous Biol Res Inst, Gangnam Severance Hosp, Dept Dermatol,Coll Med, Seoul, South Korea; Soonchunhyang Univ, Cheonan Hosp, Dept Dermatol, Coll Med, Cheonan, South Korea; Chonnam Natl Univ, Dept Dermatol, Sch Med, Gwangju, South Korea; Konkuk Univ, Dept Dermatol, Sch Med, Seoul, South Korea; Kyungpook Natl Univ, Dept Dermatol, Kyungpook Natl Univ Hosp, Sch Med, Daegu, South Korea; Korea Univ, Dept Dermatol, Guro Hosp, Coll Med, Seoul, South Korea; Eulji Univ, Dept Dermatol, Nowon Eulji Med Ctr, Seoul, South Korea; Catholic Univ Korea, Incheon St Marys Hosp, Dept Dermatol, 56 Dongsu Ro, Incheon 21431, South Korea | ; Park, Kui Young/JVM-7652-2024; Lee, Sang-Eun/AAS-3253-2021; Lee, Dong Hun/AAS-6021-2021; ahn, jiyoung/KSM-2201-2024; Seo, Young Joon/JHS-6247-2023; Lee, Jae-Hyun/ABE-3803-2020; Lee, JiHyun/JZC-9591-2024; Yoo, KwangHo/AFS-1720-2022; Ko, Hyun-chang/ABF-7418-2021 | 55649570908; 57202265435; 24475283700; 55429683200; 23020014500; 55966330200; 55356320800; 57283808600; 59134005300; 57207977038; 7402001312; 7202529945; 56532916200; 56382664000; 10439508900; 7102023907; 7202592703; 6701632121; 57293073200; 16645767500; 8882854500; 15033490400; 57190277285; 57016046400; 7202411345; 17434022300; 57199759766 | drchos@yahoo.co.kr; | ANNALS OF DERMATOLOGY | ANN DERMATOL | 1013-9087 | 2005-3894 | 34 | 2 | SCIE | DERMATOLOGY | 2022 | 1.6 | 77.9 | 2.56 | 2025-06-25 | 6 | 7 | Sang Hyun Cho; Dear Editor | EFFICACY; ERA | antibiotic agent; antihistaminic agent; calcineurin inhibitor; corticosteroid; cyclosporine; dupilumab; immunosuppressive agent; methotrexate; adult; allergic conjunctivitis; allergic rhinitis; antibiotic therapy; asthma; atopic dermatitis; cataract; clinical article; cohort analysis; comorbidity; controlled study; corticosteroid therapy; Dermatology Life Quality Index; desensitization; disease exacerbation; disease severity; drug efficacy; drug safety; Eczema Area and Severity Index; female; follow up; food allergy; herpes zoster; human; immunosuppressive treatment; joint stiffness; keratitis; keratoconjunctivitis; Letter; loading drug dose; long term care; maintenance drug dose; male; minimal clinically important difference; monoclonal antibody therapy; multiple cycle treatment; myalgia; neurasthenia; numeric rating scale; pain; phase 3 clinical trial (topic); phototherapy; pruritus; retina detachment; retina tear; retrospective study; rhinopharyngitis; skin disease assessment; systemic therapy; topical treatment; urticaria | English | 2022 | 2022-04 | 10.5021/ad.2022.34.2.157 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Impact of intravascular ultrasound and final kissing balloon dilatation on long-term clinical outcome in percutaneous revascularization with 1-stent strategy for left main coronary artery stenosis in drug-eluting stent era | Background It remains uncertain whether intravascular ultrasound (IVUS) use and final kissing balloon (FKB) dilatation would be standard care of percutaneous coronary intervention (PCI) with a simple 1-stent technique in unprotected left main coronary artery (LMCA) stenosis. This study sought to investigate the impact of IVUS use and FKB dilatation on long-term major adverse cardiac events (MACEs) in PCI with a simple 1-stent technique for unprotected LMCA stenosis. Methods Between June 2006 and December 2012, 255 patients who underwent PCI with 1 drug-eluting stent for LMCA stenosis were analyzed. Mean follow-up duration was 1663 +/- 946 days. Long-term MACEs were defined as death, nonfatal myocardial infarction (MI) and repeat revascularizations. Results During the follow-up, 72 (28.2%) MACEs occurred including 38 (14.9%) deaths, 21 (8.2%) nonfatal MIs and 13 (5.1%) revascularizations. The IVUS examination and FKB dilatation were done in 158 (62.0%) and 119 (46.7%), respectively. IVUS use (20.3 versus 41.2%; log-rank P < 0.001), not FKB dilatation (30.3 versus 26.5%; log-rank P = 0.614), significantly reduced MACEs. In multivariate analysis, IVUS use was a negative predictor of MACEs [hazards ratio 0.51; 95% confidence interval (CI) 0.29-0.88; P = 0.017], whereas FKB dilatation (hazard ratio 1.68; 95% CI, 1.01-2.80; P = 0.047) was a positive predictor of MACEs. In bifurcation LMCA stenosis, IVUS use (18.7 versus 48.0%; log-rank P < 0.001) significantly reduced MACEs. In nonbifurcation LMCA stenosis, FKB dilatation showed a trend of increased MACEs (P = 0.076). Conclusion IVUS examination is helpful in reducing clinical events in PCI for LMCA bifurcation lesions, whereas mandatory FKB dilatation after the 1-stent technique might be harmful in nonbifurcation LMCA stenosis. | Yoon, Jae Yong; Lee, Jang Hoon; Choi, Hyohun; Park, Hyuk Kyoon; Lee, Eunkyu; Kim, Myeong Seop; Kwon, Youngjoon; Jang, Se Yong; Bae, Myung Hwan; Yang, Dong Heon; Park, Hun Sik; Cho, Yongkeun; Chae, Shung Chull | CHA Univ, CHA Gumi Med Ctr, Dept Internal Med, Gumi, South Korea; Kyungpook Natl Univ, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Daegu, South Korea | Park, Hang-soo/AEH-1640-2022 | 57685050700; 54581258000; 57723256300; 57221712499; 57722787900; 57371425600; 57371880800; 57207977889; 36607356800; 35277423400; 57198844106; 9249593500; 7101962036 | ljhmh75@knu.ac.kr; | CORONARY ARTERY DISEASE | CORONARY ARTERY DIS | 0954-6928 | 1473-5830 | 31 | 1 | SCIE | CARDIAC & CARDIOVASCULAR SYSTEMS | 2022 | 1.8 | 78.0 | 0.59 | 2025-06-25 | 4 | 5 | balloon; bifurcation; intravascular ultrasound; left main coronary artery disease | CRUSH TECHNIQUE; SIDE-BRANCH; BIFURCATION LESIONS; BYPASS GRAFT; INTERVENTION; THROMBOSIS; IMPLANTATION; SURGERY; PREDICTORS; SOCIETY | Balloon; Bifurcation; Intravascular ultrasound; Left main coronary artery disease | Aged; Angioplasty, Balloon, Coronary; Coronary Angiography; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Revascularization; Outcome Assessment, Health Care; Proportional Hazards Models; Risk Factors; Treatment Outcome; Ultrasonography, Interventional; aged; complication; coronary angiography; drug eluting stent; female; heart infarction; heart muscle revascularization; human; interventional ultrasonography; male; middle aged; mortality; procedures; proportional hazards model; risk factor; transluminal coronary angioplasty; treatment outcome | English | 2022 | 2022-01 | 10.1097/mca.0000000000001101 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Comparative Study Between Radioisotope Uptake and Fluorescence Intensity of Indocyanine Green for Sentinel Lymph Node Biopsy in Breast Cancer | Recently, several breast surgeons have reported a new method for sentinel lymph node biopsy (SLNB) by using indocyanine green (ICG) with infrared camera. This study aimed to determine whether the lymph nodes (LNs) with ICG uptake are true SLNs and to assess the reliability of using only ICG for SLNB. Data were prospectively collected between April and September 2021. All palpable LNs were fat-trimmed and ordered from high to low signal of the gamma detector. The degree of radioisotope uptake and brightness of ICG staining of the axillary LNs detected with a fluorescent camera were compared and associated factors were analyzed. Discordance was defined as sentinel LNs (SLNs) showing a single uptake of radioisotope or fluorescence of ICG only, or when the orders of uptake and intensity degree were different between the 2 materials. A total of 79 SLNBs were performed on 78 patients with breast cancer. The breast cancer was classified as cTis-2N0-1. The discordance rate was 14/79 (17.7%) overall and 45/270 (16.7%) of the total retrieved axillary LNs. The first SLNs showed the lowest discordance rate of 6.3%, whereas the second and third SLNs showed higher discordance rates of 27.6% and 60.0%, respectively. There were no associated clinicopathologic factors that affected the discordance between uptake of radioisotope and fluorescence intensity of ICG. The use of ICG alone for SLNB may be insufficient because of the high discordance rates between radioisotopes and ICG uptake. However, the first SLN could be cautiously regarded as a true SLN. | Kang, Byeongju; Lee, Jong Ho; Lee, Jeeyeon; Jung, Jin Hyang; Kim, Wan Wook; Chu, Gyoyeong; Chae, Yeesoo; Lee, Soo Jung; Lee, In Hee; Yang, Jung Dug; Lee, Joon Seok; Park, Ho Yong | Kyungpook Natl Univ, Kyungpook Natl Univ Chilgok Hosp, Sch Med, Dept Surg, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Chilgok Hosp, Sch Med, Dept Plast & Reconstruct Surg, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Chilgok Hosp, Sch Med, Dept Hematol Oncol, Daegu, South Korea | Lee, Jong-Mok/KVY-9550-2024; LEE, JIN/Q-3108-2018; PARK, JUN-YOUNG/P-5981-2015; Yang, Jung/R-7806-2019 | 57279815300; 57212661146; 37079213100; 57209310173; 26023273400; 57796459200; 57190793908; 57203597252; 57191881516; 55171704700; 56496041000; 56564377200 | phy123@knu.ac.kr; | JOURNAL OF BREAST CANCER | J BREAST CANCER | 1738-6756 | 2092-9900 | 25 | 3 | SCIE | ONCOLOGY | 2022 | 2.4 | 78.2 | 0.66 | 2025-06-25 | 6 | 7 | Breast Neoplasms; Indocyanine Green; Radioisotopes; Sentinel Lymph Node | ONCOLOGY; SURGERY | Breast Neoplasms; Indocyanine Green; Radioisotopes; Sentinel Lymph Node | estrogen receptor; indocyanine green; progesterone receptor; radioisotope; adjuvant chemotherapy; adult; anesthesia; Article; axillary lymph node dissection; breast cancer; controlled study; ductal breast carcinoma in situ; echography; female; fine needle aspiration biopsy; fluorescence intensity; histology; hormonal therapy; human; human experiment; major clinical study; mammography; middle aged; needle biopsy; sentinel lymph node biopsy; triple negative breast cancer; tumor volume | English | 2022 | 2022-06 | 10.4048/jbc.2022.25.e27 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Article | Olaparib in patients with mCRPC with homologous recombination repair gene alterations: PROfound Asian subset analysis | Background: The Phase III PROfound study (NCT02987543) evaluated olaparib versus abiraterone or enzalutamide (control; randomized 2:1 to olaparib or control) in men with homologous recombination repair gene alterations and metastatic castration-resistant prostate cancer whose disease progressed on prior next-generation hormonal agent. Methods: We present efficacy and safety data from an exploratory post hoc analysis of olaparib in the PROfound Asian subset. Analyses were not planned, alpha controlled or powered. Of 101 Asian patients enrolled in Japan (n=57), South Korea (n=29) and Taiwan (n=15), 66 and 35 patients received olaparib and control, respectively. Results: Radiographic progression-free survival (rPFS) and overall survival (OS) favored olaparib versus control in Cohort A [rPFS 7.2 vs. 4.5 months, HR 0.58, 95% CI 0.29-1.21, P = 0.14 (nominal); OS 23.4 vs. 17.8 months, HR 0.81, 95% CI 0.40-1.74, P = 0.57 (nominal)] and Cohorts A+B [rPFS 5.8 vs. 3.5 months, HR 0.69, 95% CI 0.42-1.16, P = 0.13 (nominal); OS 18.6 vs. 16.2 months, HR 0.96, 95% CI 0.56-1.70, P = 0.9 (nominal)]. Olaparib showed greatest improvement in patients harboring BRCA alterations [rPFS 9.3 vs. 3.5 months, HR 0.17, 95% CI 0.06-0.49, P = 0.0003 (nominal); OS 26.8 vs. 14.3 months, HR 0.62, 95% CI 0.24-1.79, P = 0.34 (nominal)]. Safety data were consistent with the known profile of olaparib, with no new safety signals identified. Conclusion: In PROfound, there was a statistically significant improvement in outcomes reported in the global population of patients with metastatic castration-resistant prostate cancer and alterations in homologous recombination repair genes whose disease progressed on prior next-generation hormonal agent compared with control. For the subset of Asian patients reported here, exploratory analysis suggested that there was also an improvement in outcomes versus control. The safety and tolerability of olaparib in Asian patients were similar to that of the PROfound global population. © 2022 The Author(s). | Matsubara, Nobuaki; Nishimura, Kazuo; Kawakami, Satoru; Joung, Jae Young; Uemura, Hiroji; Goto, Takayuki; Kwon, Tae Gyun; Sugimoto, Mikio; Kato, Masashi; Wang, Shian-Shiang; Pang, See-Tong; Chen, Chung-Hsin; Fujita, Tomoko; Nii, Masahiro; Shen, Liji; Dujka, Melanie; Hussain, Maha; De Bono, Johann | National Cancer Center Hospital East, Chiba, Japan; Osaka International Cancer Institute, Osaka, Japan; Saitama Medical University Saitama Medical Center, Saitama, Japan; National Cancer Center, Goyang-si, South Korea; Yokohama City University Medical Center, Yokohama, Japan; Department of Urology, Kyoto University Hospital, Kyoto, Japan; Chilgok Kyungpook National University Medical Center, Daegu, South Korea; Department of Urology, Kagawa University Hospital, Kagawa, Japan; Department of Urology, Nagoya University Hospital, Nagoya, Japan; Division of Urology, Department of Surgery, Veterans General Hospital Taichung, Taichung, Taiwan; Department of Uro-oncology, Chang Gung Medical Foundation-LinKou Branch, Taoyuan City, Taiwan; Department of Urology, National Taiwan University Hospital, Taipei, Taiwan; AstraZeneca, Osaka, Japan; AstraZeneca, Osaka, Japan; Merck & Co., Inc., Kenilworth, NJ, United States; AstraZeneca, Gaithersburg, MD, United States; Division of Hematology-Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States; Drug Development Unit, Institute of Cancer Research and Royal Marsden Hospital, London, United Kingdom | 37098892800; 55730600000; 7201666668; 57222985702; 35491780600; 35339241400; 15073765400; 57206266865; 7406303271; 7410347509; 7402528885; 25921037500; 57936953900; 22938868700; 57683944700; 14321545600; 34770893400; 7003906526 | nmatsuba@east.ncc.go.jp; | Japanese Journal of Clinical Oncology | JPN J CLIN ONCOL | 0368-2811 | 1465-3621 | 52 | 5 | SCIE | ONCOLOGY | 2022 | 2.4 | 78.2 | 1.42 | 2025-06-25 | 14 | BRCA; homologous recombination repair gene alteration; mCRPC; olaparib; PROfound | Antineoplastic Combined Chemotherapy Protocols; Humans; Male; Phthalazines; Piperazines; Prostatic Neoplasms, Castration-Resistant; Recombinational DNA Repair; abiraterone; BRCA1 associated ring domain protein 1; BRCA1 protein; BRCA2 protein; checkpoint kinase 1; checkpoint kinase 2; enzalutamide; Fanconi anemia group L protein; olaparib; partner and localizer of BRCA2; prednisone; antineoplastic agent; olaparib; phthalazine derivative; piperazine derivative; adult; aged; anemia; Article; backache; BARD1 gene; BRIP1 gene; cancer growth; CDK12 gene; CHEK1 gene; CHEK2 gene; cohort analysis; constipation; controlled study; coughing; decreased appetite; diarrhea; dizziness; drug efficacy; drug safety; drug tolerability; exploratory research; FANCL gene; fatigue; gene mutation; human; Japan; jaw osteonecrosis; leukocyte count; major clinical study; malaise; male; metastatic castration resistant prostate cancer; nausea; neutropenia; overall survival; PALB2 gene; phase 3 clinical trial; PPP2R2A gene; progression free survival; RAD51B gene; RAD51C gene; RAD51D gene; RAD54L gene; recombination repair; rhinopharyngitis; side effect; South Korea; Taiwan; tumor suppressor gene; vomiting; castration resistant prostate cancer; genetics; pathology; recombination repair | English | Final | 2022 | 10.1093/jjco/hyac015 | 바로가기 | 바로가기 | 바로가기 | |||||||
| ○ | ○ | Article | Pharmacokinetic Drug Interaction Between Raloxifene and Cholecalciferol in Healthy Volunteers | Osteoporosis is a common skeletal disorder, often leading to fragility fracture. Combination therapy with raloxifene, a selective estrogen receptor modulator, and cholecalciferol (vitamin D-3) has been proposed to improve the overall efficacy and increase compliance of raloxifene therapy for postmenopausal osteoporosis. To our knowledge, there has been no report of any study on the pharmacokinetic interaction between raloxifene and cholecalciferol. This study aimed to evaluate the possible pharmacokinetic interactions between raloxifene and cholecalciferol in healthy adult male Korean volunteers. Twenty subjects completed this open-label, randomized, single-dose, 3-period, 6-sequence, crossover phase I study with a 14-day washout period. Serial blood samples were collected from 20 hours before dosing to 96 hours after dosing. The plasma concentrations of raloxifene and cholecalciferol were determined using a validated method for high-performance liquid chromatography with tandem mass spectrometry. The geometric mean ratios (90%CIs) for area under the plasma concentration-time curve from time 0 to the last quantifiable time point and maximum plasma concentration of raloxifene with or without cholecalciferol were 1.02 (0.87-1.20) and 0.87 (0.70-1.08), respectively. For baseline-corrected cholecalciferol, geometric mean ratios (90%CIs) of area under the plasma concentration-time curve from time 0 to the last quantifiable time point and maximum plasma concentration with or without raloxifene were 1.01 (0.93-1.09) and 0.99 (0.92-1.06), respectively. Concurrent treatment with raloxifene and cholecalciferol was generally well tolerated. These results suggest that raloxifene and cholecalciferol have no clinically relevant pharmacokinetic drug-drug interactions when administered concurrently. All treatments were well tolerated, with no serious adverse events. | Lee, Hae Won; Kang, Woo Youl; Jung, Wookjae; Gwon, Mi-Ri; Cho, Kyunghee; Lee, Backhwan; Seong, Sook Jin; Yoon, Young-Ran | Kyungpook Natl Univ, Sch Med, Dept Mol Med, 130 Dongduk Ro, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Dept Clin Pharmacol, 130 Dongduk Ro, Daegu 41944, South Korea; Biocore Co Ltd, Analyt Res Div, Seoul, South Korea; Alvogen Korea Co Ltd, Dept Clin Dev, Seoul, South Korea | Yoon, Young-Ran/GLT-0172-2022 | 57202973823; 56816263900; 57218206353; 56035800800; 57211130109; 57192838300; 57211130049; 14629744500 | yry@knu.ac.kr; | CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT | CLIN PHARM DRUG DEV | 2160-7648 | 11 | 5 | SCIE | PHARMACOLOGY & PHARMACY | 2022 | 2 | 78.2 | 0.52 | 2025-06-25 | 3 | 4 | cholecalciferol; drug-drug interaction; osteoporosis; pharmacokinetics; raloxifene | POSTMENOPAUSAL WOMEN; HIGH PREVALENCE; OSTEOPOROSIS; TOLERABILITY; TRANSPORTERS; COMBINATION; VITAMIN-D-3; DEFICIENCY; PREVENTION; EFFLUX | cholecalciferol; drug-drug interaction; osteoporosis; pharmacokinetics; raloxifene | Adult; Cholecalciferol; Cross-Over Studies; Drug Interactions; Healthy Volunteers; Humans; Male; Raloxifene Hydrochloride; admin forte; colecalciferol; raloxifene; colecalciferol; raloxifene; adult; Article; controlled study; crossover procedure; drug blood level; drug tolerability; futurology; high performance liquid chromatography; human; liquid chromatography-mass spectrometry; male; open study; pharmacokinetic parameters; plasma concentration-time curve; postmenopause osteoporosis; randomized controlled trial; single drug dose; tablet; time to maximum plasma concentration; unspecified side effect; clinical trial; drug interaction; normal human; phase 1 clinical trial | English | 2022 | 2022-05 | 10.1002/cpdd.1062 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Relationship Between Breast and Axillary Pathologic Complete Response According to Clinical Nodal Stage: A Nationwide Study From Korean Breast Cancer Society | Purpose: We evaluated the relationship between breast pathologic complete response (BpCR) and axillary pathologic complete response (ApCR) after neoadjuvant chemotherapy (NACT) according to nodal burden at presentation. As the indications for NACT have expanded, clinicians have started clinical trials for the omission of surgery from the treatment plan in patients with excellent responses to NACT. However, the appropriate indications for axillary surgery omission after excellent NACT response remain unclear. Methods: Data were collected from patients in the Korean Breast Cancer Society Registry who underwent NACT followed by surgery between 2010 and 2020. We analyzed pathologic axillary nodal positivity after NACT according to BpCR stratified by tumor subtype in patients with cT1-3/N0-2 disease at diagnosis. Results: A total of 6,597 patients were identified. Regarding cT stage, 528 (9.5%), 3,778 (67.8%), and 1,268 (22.7%) patients had cT1, cT2, and cT3 disease, respectively. Regarding cN stage, 1,539 (27.7%), 2,976 (53.6%), and 1,036 (18.7%) patients had cNO, cN1, and cN2 disease, respectively. BpCR occurred in 21.6% (n = 1,427) of patients, while ApCR and pathologic complete response (ypCR) occurred in 59.7% (n = 3,929) and ypCR 19.4% (n = 1,285) of patients, respectively. The distribution of biologic subtypes included 2,329 (39.3%) patients with hormone receptor (HR)-positive/human epidermal growth factor receptor 2 (HER2)-negative disease, 1,122 (18.9%) with HR-positive/HER2-positive disease, 405 (6.8%) with HR-negative/HER2-positive disease, and 2,072 (35.0%) with triple-negative breast cancer. Among the patients with BpCR, 89.6% (1,122/1,252) had ApCR. Of those with cNO disease, most (99.0%, 301/304) showed ApCR. Among patients with cN1-2 disease, 86.6% (821/948) had ApCR. Conclusion: BpCR was highly correlated with ApCR after NACT. In patients with cN0 and BpCR, the risk of missing axillary nodal metastasis was low after NACT. Further research on axillary surgery omission in patients with cN0 disease is needed. | Ryu, Jai Min; Choi, Hee Jun; Park, Eun Hwa; Kim, Ji Young; Lee, Young Joo; Park, Seho; Lee, Jeeyeon; Park, Heung Kyu; Nam, Seok Jin; Kim, Seok Won; Lee, Jun-Hee; Lee, Jeong Eon | Sungkyunkwan Univ, Samsung Med Ctr, Dept Surg, Div Breast Surg,Sch Med, 81 Irwon Ro, Seoul 06351, South Korea; Sungkyunkwan Univ, Samsung Changwon Hosp, Dept Surg, Sch Med, Chang Won, South Korea; Dong A Univ, Dong A Univ Hosp, Coll Med, Dept Surg, Busan, South Korea; Ajou Univ Hosp, Dept Surg, Suwon, South Korea; Asan Med Ctr, Dept Surg, Seoul, South Korea; Yonsei Univ, Dept Surg, Div Breast Surg, Coll Med, Seoul, South Korea; Kyungpook Natl Univ, Div Breast Surg, Chilgok Hosp, Daegu, South Korea; Gachon Univ, Dept Breast Canc Surg, Gil Med Ctr, Incheon, South Korea | ; Kim, Seok-Mo/AAK-5898-2020; Park, Eun/W-1340-2019; Lee, Jong-Mok/KVY-9550-2024; Park, Seho/LUZ-3414-2024; Lee, Jeeyun/I-7171-2015 | 57158270000; 57192653591; 25923124900; 55155943800; 58019185800; 55717320100; 37079213100; 23493632300; 7402276023; 55949767700; 57203144429; 57200181799 | paojlus@hanmail.net; | JOURNAL OF BREAST CANCER | J BREAST CANCER | 1738-6756 | 2092-9900 | 25 | 2 | SCIE | ONCOLOGY | 2022 | 2.4 | 78.2 | 0.95 | 2025-06-25 | 10 | 10 | Breast Neoplasms; Complete Response; Neoadjuvant Therapy | SURGICAL ADJUVANT BREAST; NEOADJUVANT CHEMOTHERAPY; SENTINEL NODE; PREOPERATIVE CHEMOTHERAPY; CONSERVING THERAPY; MULTICENTER; PROTOCOL; SURGERY; IMPACT; WOMEN | Breast Neoplasms; Complete Response; Neoadjuvant Therapy | epidermal growth factor receptor; epidermal growth factor receptor 2; estrogen receptor; hormone receptor; progesterone receptor; adult; Article; axillary lymph node; breast cancer; breast disease; cancer grading; cancer patient; cancer staging; cancer surgery; distant metastasis; female; histology; human; human epidermal growth factor receptor 2 positive breast cancer; human tissue; immunohistochemistry; information processing; Korean (people); lymph node dissection; male; mastectomy; metastasis; neoadjuvant therapy; retrospective study; sentinel lymph node biopsy | English | 2022 | 2022-04 | 10.4048/jbc.2022.25.e17 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Pressure profile calculation using finite element analysis that exploits the continuity of gas flow | We present a numerical method of calculating the pressure profile of a large ultra-high vacuum (UHV) system using finite-element analysis (FEA) that exploits the continuity of gas flow. In this study, we introduce a modified FEA (MFEA) that excludes the redundant count of aperture conductance of the element by the Oatley method and uses a correction factor compensating the beaming effect. Along with the correction and by choosing an appropriate length of the element, we improve the result for a cylindrical tube to show a small difference of 5% or less from that of the test particle Monte Carlo (TPMC) simulation. As an example of a practical application, we calculate the pressure profile of an accelerator vacuum system with a split chamber using the MFEA, and the result is validated by comparison with the TPMC. The MFEA method will be useful to design a large UHV system at an early stage that requires design iteration using a simple and fast calculation procedure. (C) 2022 Author(s). | Noh, Hyeongrae; Kim, Se-Hyun; Kim, Jeehoon; Park, Chongdo; Ha, Taekyun | Pohang Univ Sci & Technol, Dept Phys, 77 Cheongam Ro, Pohang 37673, Gyeongbuk, South Korea; Pohang Accelerator Lab, 80 Jigok Ro 127 Beon Gil, Pohang 37673, Gyeongbuk, South Korea; Kyungpook Natl Univ, Dept Phys, 80 Daehak Ro, Daegu 41566, South Korea | Kim, Jeehoon/K-3763-2012; Ha, Taekyun/HCI-0717-2022; Kim, Sehyun/KDN-3343-2024 | 57196425088; 59102682600; 56404221700; 55885569500; 26534131400 | hatae@postech.ac.kr; | AIP ADVANCES | AIP ADV | 2158-3226 | 12 | 3 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY;PHYSICS, APPLIED | 2022 | 1.6 | 78.4 | 0.08 | 2025-06-25 | 1 | 1 | VACUUM-SYSTEMS; STORAGE-RING; LONG TUBE; SIMULATION; CODE | Flow of gases; Iterative methods; Monte Carlo methods; Numerical methods; Ultrahigh vacuum; Beaming effect; Correction factors; Cylindrical tubes; Design iteration; Finite element analyse; Monte Carlo's simulation; Pressure profiles; Profile calculation; Simple++; Test Particle Monte-Carlo; Finite element method | English | 2022 | 2022-03-01 | 10.1063/6.0001583 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Understanding effect of distortions and vacancies in wurtzite AlScN ferroelectric memory materials: Vacancy-induced multiple defect state types and relaxation dependence in transition energy levels | Energy-efficient compact alternatives to fully digital computing strategies could be achieved by implementations of artificial neural networks (ANNs) that borrow analog techniques. In-memory computing based on crossbar device architectures with memristive materials systems that execute, in an analog way, multiply-and-accumulate operations prevalent in ANN is a notable example. Ferroelectric (FE) materials are promising candidates for achieving ANN thanks to their excellent down-scalability, improved electrical control, and high energy efficiency. However, it remains challenging to develop a crossbar device architecture using FE materials. The difficulty stems from decreasing the leakage current of FE hardware and, simultaneously, reducing the film thickness for achieving compact systems. Here, we have performed density-functional-theory calculations to investigate the electronic, energy-based, and structural signatures of wurtzite FE material Al0.75Sc0.25N with a nitrogen vacancy (V-N) in different charge states. We find that V-N can introduce two defect states, viz., the singlet state above the valence band maximum (VBM) and a triplet state below the conduction band minimum in wurtzite AlScN models. The calculations reveal that the group of transition levels E3+/2+/E2+/1+ with small formation energies occur at & SIM;0.78/1.03 eV above the VBM in the wurtzite AlScN with a relaxed configuration, which may shift by a large degree to lower energy levels if atoms surrounding the defect are not fully relaxed. Theoretical studies elucidate the vacancy-enhanced increase in the leakage current utilizing large AlScN supercells. These findings render atomistic insights that can provide a path forward for the design of next-generation portable low-power electronic systems. | Wang, Qiang; Go, Shao-Xiang; Liu, Chen; Li, Minghua; Zhu, Yao; Li, Lunna; Lee, Tae Hoon; Loke, Desmond K. | Singapore Univ Technol & Design, Dept Sci Math & Technol, Singapore 487372, Singapore; Agcy Sci Technol & Res, Inst Microelect, Singapore 138634, Singapore; Kyungpook Natl Univ, Sch Mat Sci & Engn, Daegu 41566, South Korea | Lee, Tae/AAB-7490-2021; Wang, Qiang/AAV-7131-2021; Li, Minghua/D-8632-2011 | 57219146363; 57226116052; 57146634200; 8507369800; 37071731400; 57221106276; 55731221000; 36096853500 | desmond_loke@sutd.edu.sg; | AIP ADVANCES | AIP ADV | 2158-3226 | 12 | 12 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY;PHYSICS, APPLIED | 2022 | 1.6 | 78.4 | 0.57 | 2025-06-25 | 7 | 7 | REDUCED LEAKAGE CURRENT; INTEGRATION | Computation theory; Defect states; Density functional theory; Energy efficiency; Ferroelectric materials; Memory architecture; Network architecture; Zinc sulfide; Computing strategies; Defect state; Device architectures; Energy efficient; Ferroelectric memory; Ferroelectrics materials; Memory materials; Multiple defects; Transition energy levels; Valence-band maximums; Ferroelectricity | English | 2022 | 2022-12-01 | 10.1063/5.0126651 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Macroeconomic dynamics under bounded rationality: on the impact of consumers' forecast heuristics | This paper considers various types of forecast heuristics to examine the effects of boundedly rational agents on macroeconomic dynamics. Given the baseline New Keynesian model, we seek to find the expectation formation process that is most suitable in describing economic adjustments over the business cycle. In particular, impulse response analysis is used to compare the performances of the macroeconomic model under bounded rationality and under rational expectations. The results show that the fluctuations in consumer confidence mainly explain the degree of persistence in consumption. We conclude that a model under bounded rationality with a heuristic-induced switching process can qualitatively provide a good fit to the data that is equivalent to a model under rational expectations. | Jang, Tae-Seok; Sacht, Stephen | Kyungpook Natl Univ, Dept Econ, 80 Daehak Ro, Daegu 41566, South Korea; Univ Kiel, Dept Econ, Olshausenstr 40, D-24118 Kiel, Germany | Jang, Tae-Seok/AFP-9841-2022 | 55951739600; 55181774300 | taeseok.jang@gmail.com;sacht@economics.uni-kiel.de; | JOURNAL OF ECONOMIC INTERACTION AND COORDINATION | J ECON INTERACT COOR | 1860-711X | 1860-7128 | 17 | 3 | SSCI | ECONOMICS | 2022 | 1.1 | 78.6 | 0.08 | 2025-06-25 | 1 | 1 | Bounded rationality; Consumer confidence; Forecast heuristics; Impulse response analysis; New Keynesian model | ANIMAL SPIRITS; FISCAL-POLICY; EXPECTATIONS | Bounded rationality; Consumer confidence; Forecast heuristics; Impulse response analysis; New Keynesian model | English | 2022 | 2022-07 | 10.1007/s11403-022-00348-7 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | A Rare Case of Osseous Metaplasia in Canine Leiomyoma and Plasticity of Smooth Muscle Cell | Metaplasia is a transformation of one mature cell type to other kinds of mature cells. Metaplasia is hardly detected in benign tumors, whereas it is frequently observed in malignant tumors. In this study, we report the first case of osseous metaplasia in canine leiomyoma. The region of osseous metaplasia was highly eosinophilic and had various sizes of distinct lacunae. The osseoid material was confirmed by Von Kossa staining. Except for the osseous metaplasia, the mass presented typical features of leiomyoma without any histopathological features of malignancy. The characteristics of malignant tumors, including pleomorphism, mitotic figures, and lymphatic metastasis were not identified and the mass was proven to be a benign tumor. The osseous metaplasia in leiomyoma without dysplastic changes might be due to plasticity which is a unique feature of smooth muscle cells, whether the tumor is malignant or not. This case suggests the possible occurrence of osseous metaplasia in leiomyoma, which has been overlooked due to the lack of reports. Also, it is recommended to pay attention to making a diagnosis of smooth muscle tumor with metaplasia so as not to be confused with leiomyosarcoma and leiomyoma variants. | Lee, Eun-Joo; Jeong, Kyu-Shik | Kyungpook Natl Univ, Dept Vet Pathol, Coll Vet Med, Daegu City, South Korea | Jeong, Kyu-Shik/D-6740-2011 | 58363110000; 7201556460 | jeongks@knu.ac.kr; | ACTA VETERINARIA-BEOGRAD | ACTA VET-BEOGRAD | 0567-8315 | 1820-7448 | 72 | 2 | SCIE | VETERINARY SCIENCES | 2022 | 0.6 | 78.8 | 0 | 2025-06-25 | 0 | 0 | Osseous metaplasia; smooth muscle; benign; leiomyoma; dog | BENIGN METASTASIZING LEIOMYOMA; TUMORS; DOG | benign; dog; leiomyoma; Osseous metaplasia; smooth muscle | desmin; eosin; hematoxylin; smooth muscle actin; vimentin; animal cell; animal experiment; animal tissue; appetite; Article; benign neoplasm; blood chemistry; body temperature; bone disease; Canis; cell plasticity; cytoplasm; defecation; dog; female; follow up; hemangiopericytoma; histopathology; immunohistochemistry; leiomyoma; leiomyosarcoma; lymph node metastasis; metaplasia; microscopy; muscle tumor; nerve sheath tumor; neurilemoma; nonhuman; platelet count; radiography; rhabdomyoma; smooth muscle cell; tumor cell; tumor growth | English | 2022 | 2022-06-01 | 10.2478/acve-2022-0021 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Expression analysis of OsSERK, OsLEC1 and OsWOX4 genes in rice (Oryza sativa L.) callus during somatic embryo development | Somatic embryogenesis is an asexual reproduction process that occurs in many plant species, including rice. This process contains several totipotency markers such as Somatic Embryogenesis Receptor-like Kinase (SERK), Leafy Cotyledonl (LEC1) and WUSCHEL-Related Homeobox4 (WOX4) and also a helpful model for embryo development and clones and transformations. Here, we report the gene expression during somatic embryo development correlates with regeneration frequency in 14 Javanica rice (pigmented and non-pigmented) using modified N6 media supplemented with Kinetin (2.0 mg/L) and NAA (1.0 mg/L). Although there have been advances in understanding the genetic basis of somatic embryogenesis in other varieties, rice is still unexplored, especially during somatic embryo development. Moreover, for the formation of callus induction from immature embryos, 2,4-D (2.0 mg/L, 3.0 mg/L) was used. This study analysed the gene expression of OsSERK, OsWOX4 and OsLEC1 genes through RT-PCR analysis. Higher expression of the OsLEC1 gene indicates that their function may correlate in the in vitro with the high response of rice after transfer to regeneration media. This study found that rice varieties of pigmented rice (MS Pendek and Gogoniti II) and non-pigmented rice (Pandan Ungu) showed high regeneration frequency, showing higher OsLEC1 expression than other varieties because OsLEC1 promotes the maturation of somatic embryos in plant regeneration on day 14. However, the contrast with Genjah nganjuk may be effective because of other regulatory genes. RT-PCR analysis showed OsSERK had less expression level than OsLEC1 and OsWOX4 in the varieties, which correlate with the percentage of plant regeneration, but not for Gogoniti II. In conclusion, the higher percentage of plant regeneration correlates with the higher expression level of OsLEC1 at day 14 of media regeneration of rice. | Nabilah, Siti; Handoyo, Tri; Kim, Kyung-Min; Ubaidillah, Mohammad | Univ Jember, Grad Sch Biotechnol, Jember 68121, Indonesia; Univ Jember, Fac Agr, Jember 68121, Indonesia; Univ Jember, Ctr Dev Adv Sci & Technol CDAST, Jember 68121, Indonesia; Kyungpook Natl Univ, Coll Agr & Life Sci, Sch Appl BioSci, Div Plant Biosci, Daegu 41566, South Korea | Ubaidillah, Mohammad/HRD-1784-2023; Handoyo, Tri/AGX-6311-2022; Kim, Kyung-Min Kim/C-7007-2014 | 57214723268; 12775151000; 34868260300; 56011434400 | moh.ubaidillah.pasca@unej.ac.id; | BIOCELL | BIOCELL | 0327-9545 | 1667-5746 | 46 | 7 | SCIE | BIOLOGY | 2022 | 1.2 | 78.8 | 0.16 | 2025-06-25 | 1 | 2 | Javanica rice; OsLEC1; OsSERK; OsWOX4; Plant regeneration; Somatic embryos | EMBRYOGENESIS; INDUCTION | Javanica rice; OsLEC1; OsSERK; OsWOX4; Plant regeneration; Somatic embryos | kinetin; Article; callus (plant); correlation analysis; embryo; fresh weight; gene expression level; gene expression profiling; in vitro study; leafy cotyledon1 gene; maturation; nonhuman; plant regeneration; plant structures; real time polymerase chain reaction; regulator gene; rice; somatic embryogenesis; somatic embryogenesis receptor like kinase gene; varietas; WUSCHEL related homeobox4 gene | English | 2022 | 2022 | 10.32604/biocell.2022.019111 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Mammary Adenoma Associated with Chronic Mastitis in a Wild Boar (Sus Scrofa) | Mammary gland tumor is rare and only a few cases have been reported in wild animals. Moreover, most etiologies of the known cases in veterinary medicine are related to age, diet, obesity, and excessive sex hormones in domestic animals while few etiologies are reported in wild animals. An unknown-aged female wild boar was presented to the Department of Veterinary Pathology, Kyungpook National University with a well-demarcated, and firm-to-elastic mammary gland mass. The cut-surface of the mass was pink-reddish, and homogeneous. Microscopically, the mass was mainly composed of well-differentiated neoplastic glandular epithelial cells characterized by a single-layer, columnar to cuboidal shapes, and small and central nuclei and nucleoli. Any evidence of invasiveness or metastases of the neoplastic cells were not observed. Interestingly, infiltration of chronic inflammatory cells such as plasma cells and macrophages was observed along with a large quantity of gram-negative and positive bacterial colonies in the mammary glands. Moreover, accompanied fibrosis of stroma was observed, as well. Based on the gross and microscopic findings, the present case was diagnosed as mammary simple adenoma caused by chronic mastitis progressing to fibrotic condition. To the authors' knowledge, this is the first study describing the histopathological aspects of mammary gland tumors associated with chronic mastitis accompanied by fibrosis in wild animals. | Baek, Su-Min; Lee, Seoung-Woo; Park, Jin-Kyu | Kyungpook Natl Univ, Dept Vet Pathol, Coll Vet Med, Daegu, South Korea | 57207938426; 57218827581; 35213723500 | jinkyu820@knu.ac.kr; | ACTA VETERINARIA-BEOGRAD | ACTA VET-BEOGRAD | 0567-8315 | 1820-7448 | 72 | 3 | SCIE | VETERINARY SCIENCES | 2022 | 0.6 | 78.8 | 0 | 2025-06-25 | 0 | 0 | Adenoma; fibrosis; mammary gland; mastitis; wild boar | CANCER | Adenoma; fibrosis; mammary gland; mastitis; wild boar | eosin; hematoxylin; sex hormone; adenoma; animal tissue; Article; breast tumor; case report; clinical article; connective tissue; epithelium cell; female; fibrosis; inflammatory cell; macrophage; mammary gland; mastitis; nonhuman; obesity; pig; stroma | English | 2022 | 2022-09-01 | 10.2478/acve-2022-0031 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | SPONTANEOUS LYMPHOMA IN A SMP30 KNOCK-OUT C57BL/6 MOUSE | 70-weeks-old female C57BL6 senescence marker protein 30 knock out mice exhibited anorexia, lethargy and enlarged abdomen because of an intraperitoneal mass. On necropsy, the mouse revealed a large brown-whitish mass located on the mesentery. The mass also exhibited systemic metastasis and spread over in various organs. On microscopic findings, the neoplastic masses were mainly composed of neoplastic round cells characterized by severe anisokaryosis, narrow cytoplasm, round nuclei, prominent nucleoli, and numerous mitotic figures (13-15 in a 400X field). Consequently, the present case was diagnosed as a metastatic lymphoma arising from a mesenteric lymph node, the tumor spread to other organs such as the intestine, kidney and thoracic cavity. According to previous studies, SMP30 plays an important role in inhibiting cancer in both human and mouse. Taken together, it seems that the present case can be used as a valuable asset for evaluating the potential risks of SMP30 depletion in developing lymphoma. | Lee, Seoung-Woo; Baek, Su-Min; Lee, Young-Jin; Park, Jin-Kyu | Kyungpook Natl Univ, Coll Vet Med, Dept Vet Pathol, Daegu 41566, South Korea | 57218827581; 57207938426; 57491815500; 35213723500 | jinkyu820@knu.ac.kr; | ACTA VETERINARIA-BEOGRAD | ACTA VET-BEOGRAD | 0567-8315 | 1820-7448 | 72 | 4 | SCIE | VETERINARY SCIENCES | 2022 | 0.6 | 78.8 | 0 | 2025-06-25 | 0 | 0 | experimental animal; lymphoma; mouse; SMP30; cancer | EPIDEMIOLOGY | cancer; experimental animal; lymphoma; mouse; SMP30 | tolonium chloride; abdominal mass; amino acid sequence; animal experiment; animal tissue; Article; cancer inhibition; cancer size; enlarged abdomen; female; histiocytic sarcoma; histopathology; immunohistochemistry; knockout mouse; lymphoma; mastocytoma; mesentery lymph node; mouse; nonhuman; nucleolus; protein function; sequence analysis; thoracic cavity; upregulation | English | 2022 | 2022-12-01 | 10.2478/acve-2022-0040 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Symmetric Dimethylarginine is a Promising Biomarker for the Early Detection of Age-Related Kidney Dysfunction in Zoo Felids | Chronic renal failure is one of the leading causes of death in African lions, cheetahs, and tigers. Conventional methods to measure renal dysfunction include measuring serum creatinine and blood urea nitrogen (BUN). Symmetric dimethylarginine (SDMA) measurement is a reliable predictor of renal dysfunction in the domestic cat because SDMA serum levels increase early when the kidneys are damaged. Serum SDMA levels were assessed and correlated with creatinine as well as BUN from healthy captive Bengal tigers and lions at the Everland Zoo in Korea. Serum SDMA concentrations were increasingly associated with increased age in lions. However, SDMA concentrations were higher in some young Bengal tigers than in older ones, which may allow for earlier renal dysfunction detection in these young cats than would be BUN and creatinine alone. In Bengal tigers, the correlation between the SDMA and BUN was slightly higher than that between SDMA and creatinine. In lions, SDMA correlated better with creatinine than with BUN concentration. These results show that serum SDMA concentration can be used as a biomarker for age-associated renal dysfunction. SDMA measurement may be an essential preventive management method in zoos. | Youn, Soong-Hee; Efladl, Ahmed K.; Chung, Myung-Jin; Jung, Eun; Shin, Ki-Yong; Shin, Hyeon-Joo; Yang, Joon-Young; Heo, Kwang-Seok; Chung, Dong-Hee; Yim, Jae-Hyuk; Son, Ji-Yoon; Lee, Eun-Joo; Hong, Il-Hwa; Jeong, Kyu-Shik | Kyungpook Natl Univ, Coll Vet Med, Daegu City 41566, South Korea; Samsung Everland Zool garden, Yong in City 17023, South Korea; Gyeongsang Natl Univ, Coll Vet Med, Jinju 52828, South Korea | Chung, Myung/C-1876-2011; Jeong, Kyu-Shik/D-6740-2011 | 55876632700; 43060937500; 57193323993; 57203199731; 57929364700; 57929553700; 57929178400; 57929178500; 57204505749; 57221330255; 57211247483; 58363110000; 8702273100; 7201556460 | jeongks@knu.ac.kr; | ACTA VETERINARIA-BEOGRAD | ACTA VET-BEOGRAD | 0567-8315 | 1820-7448 | 72 | 3 | SCIE | VETERINARY SCIENCES | 2022 | 0.6 | 78.8 | 0.43 | 2025-06-25 | 3 | 2 | African lion; Bengal tiger; Symmetric dimethylarginine (SDMA) | GLOMERULAR-FILTRATION-RATE; SERUM CONCENTRATIONS; DISEASE; CATS; CREATININE; VALIDATION; DOGS | African lion; Bengal tiger; Symmetric dimethylarginine (SDMA) | 6 n,n' dimethylarginine; alanine aminotransferase; albendazole; albumin; alkaline phosphatase; amylase; aspartate aminotransferase; bilirubin; chloride; cholesterol; creatine kinase; creatinine; flubendazole; gamma glutamyltransferase; ivermectin; potassium; sodium; triacylglycerol; triacylglycerol lipase; alanine aminotransferase level; albumin level; alkaline phosphatase level; Article; aspartate aminotransferase level; basophil count; bilirubin blood level; biochemical analysis; calcium blood level; chloride blood level; chronic kidney failure; creatine kinase blood level; creatinine blood level; eosinophil count; erythrocyte count; Feline calicivirus; Feline panleukopenia virus; gamma glutamyl transferase blood level; granulocyte count; hematocrit; kidney dysfunction; lactate dehydrogenase blood level; leukocyte count; lion; lymphocyte count; mean corpuscular hemoglobin; mean corpuscular hemoglobin concentration; mean corpuscular volume; monocyte count; neutrophil count; nonhuman; platelet count; potassium blood level; sodium blood level; tiger; total cholesterol level; triacylglycerol level; triacylglycerol lipase blood level; urea nitrogen blood level; zoo animal | English | 2022 | 2022-09-01 | 10.2478/acve-2022-0033 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Flow-noise characteristics of turbocharger compressors with rotational balance cuttings | To correct the balance of the rotating assembly of a turbocharger, some parts of the compressor wheel are removed by cutting. A numerical investigation of the turbulent flows and flow noises produced by compressor wheels modified with such cutting parts was performed by a turbulence model and detached-eddy simulations. For the 6-cutting case, 0, 2, 4, and 6 circular cuttings and two additional-rectangular and triangular-shapes were used. To investigate the effects of the balance cuttings in a compressor wheel, the evaluation process using computational fluid dynamics was tried. It was found that the fluid forces due to the various wheel shapes have the potential to restore the eccentricity by approximately 50%. Severe variations of velocity, pressure, and turbulent kinetic energy in the interspace between the wheel and volute were observed. In particular, the wavelike patterns of pressure and turbulent kinetic energy were intensified for the modified wheels. The turbulent kinetic energy of the 6-cutting case had a dominant frequency at approximately 3000 Hz. The spectrum of the sound-pressure level of the modified compressor wheels exhibited the features of buzz-saw noise. The flow fields suggested that this feature of the sound pressure is related to the tip-clearance flow affected by the balance cuttings. In addition, the acoustic pressure and flow characteristics of the different types of modified compressor wheels were discussed and the resulting acoustic power was evaluated. | Kim, Sang Hyun; Park, Tae Seon | Kyungpook Natl Univ, Sch Mech Engn, 80 Daehak Ro, Daegu 41566, South Korea | 58743861500; 7401801892 | tsparkjp@knu.ac.kr; | INTERNATIONAL JOURNAL OF AEROACOUSTICS | INT J AEROACOUST | 1475-472X | 2048-4003 | 21 | 3-4 | SCIE | ACOUSTICS;ENGINEERING, AEROSPACE;MECHANICS | 2022 | 1 | 79.0 | 0.12 | 2025-06-25 | 1 | 1 | Turbocharger; compressor; balance cutting; Detached-Eddy simulation; flow noise | balance cutting; compressor; Detached-Eddy simulation; flow noise; Turbocharger | Acoustic noise; Acoustic variables measurement; Compressors; Flow separation; Kinetic energy; Kinetics; Turbomachinery; Turbulence models; Turbulent flow; Wheels; Balance cutting; Cutting part; Detached-Eddy simulation; Flow noise; Fluid forces; Noise characteristic; Numerical investigations; Triangular shapes; Turbocharger compressor; Turbulent kinetic energy; Computational fluid dynamics | English | 2022 | 2022-06 | 10.1177/1475472x221093707 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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