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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Bi-directional evolutionary 3D topology optimization with a deep neural network | The FEM-based topology optimization repeats usually finite element analyses many times to converge to the stopping criteria. If the near-optimal topology data are available in advance at the beginning of an optimization process, the iterative computation could be greatly reduced. In an effort to obtain swiftly optimum topology solutions, the deep learning and neural networks with a special segmentation scheme of digital images are combined with the BESO (bi-directional evolutionary structural optimization) topology method in this study. The pre-trained digital images of 3200 optimum topologies construct the design domain for the main topology optimization. Additionally, a new post-processor is developed in order to reconstruct the relative locations among finite elements in the raw outputs generated by the neural network. The proposed method has been demonstrated to be efficient in lowering the iterations with several 2D and 3D optimization examples. The iteration counts can be reduced 63% for a 2D example and by 72.5% for a 3D one, compared to BESO results alone. | Shin, Junseok; Kim, Cheol | Kyungpook Natl Univ, Dept Mech Engn, Daegu 41566, South Korea | 57552081200; 55508786300 | kimchul@knu.ac.kr; | JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY | J MECH SCI TECHNOL | 1738-494X | 1976-3824 | 36 | 7 | SCIE | ENGINEERING, MECHANICAL | 2022 | 1.6 | 75.4 | 0.58 | 2025-06-25 | 5 | 7 | Topology optimization; Deep learning; BESO; CNN; Python | PREDICTION | BESO; CNN; Deep learning; Python; Topology optimization | Deep neural networks; Image segmentation; Iterative methods; Shape optimization; Structural optimization; Topology; 3D topology; Bi-directional; Bi-directional evolutionary structural optimizations; Deep learning; Digital image; Finite element analyse; Neural-networks; Optimum topologies; Stopping criterion; Topology optimisation; Python | English | 2022 | 2022-07 | 10.1007/s12206-022-0628-2 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Clinical Utility of Next-generation Sequencing in Real-world Cases: A Single-institution Study of Nine Cases | Background/Aim: Targeted next-generation sequencing (NGS) is a well-established technique to detect pathogenic alterations in tumors. Indeed, it is the cornerstone of targeted therapy in precision medicine. We investigated the clinical utility of next-generation sequencing in real-world cases. Patients and Methods: We retrospectively selected six representative cancer cases, wherein targeted NGS played a pivotal role in the diagnosis and treatment of patients. Additionally, we analyzed three cases with rare, unusual pathogenic alterations. Results: Our NGS analysis revealed that four patients had TPR-ROS1, EGFR-RAD51, and NCOA4-RET fusions and MET exon 14 skipping mutation, respectively, which can be treated with targeted therapy. Furthermore, we used NGS as a diagnostic tool to confirm the origin of unknown primary malignant tumors in two cases. Interestingly, NGS also helped us identify the following cases: patients exhibiting BRCA1 and TP53 mutations that exhibited histological and immunohistochemical characteristics consistent with endometrioid carcinoma, patients with high-grade serous carcinoma not possessing a TP53 mutation, and patients with small cell lung cancer with a ERBB2 mutation and displaying no loss of RB1. Conclusion: We recommend targeted NGS for the diagnoses and targeted therapy of cancer patients. | Kim, Moonsik; Jeong, Ji Yun; Park, Nora Jee-Young; Park, Ji Young | Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Pathol, Daegu 41405, South Korea | 57195918515; 57205472984; 57226185359; 57210160197 | jyparkmd@knu.ac.kr; | IN VIVO | IN VIVO | 0258-851X | 1791-7549 | 36 | 3 | SCIE | MEDICINE, RESEARCH & EXPERIMENTAL | 2022 | 2.3 | 75.4 | 0.09 | 2025-06-25 | 1 | 1 | Next-generation sequencing; immunohistochemistry; histology; malignancy | CELL LUNG-CANCER; JOINT-CONSENSUS-RECOMMENDATION; EGFR-RAD51 FUSION; BREAST-CANCER; CARCINOMA; IMMUNOHISTOCHEMISTRY; MUTATIONS; TUMORS; ADENOCARCINOMA; CLASSIFICATION | histology; immunohistochemistry; malignancy; Next-generation sequencing | Carcinoma, Non-Small-Cell Lung; High-Throughput Nucleotide Sequencing; Humans; Lung Neoplasms; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Retrospective Studies; chromogranin A; crizotinib; cytokeratin AE1; egfr rad51 protein; homeobox protein Nkx 2.1; ncoa4 ret protein; oncogene fusion protein; protein p53; scatter factor receptor; selpercatinib; synaptophysin; tpr ros1 protein; unclassified drug; oncoprotein; protein tyrosine kinase; abdominal hysterectomy; abdominal metastasis; adrenal metastasis; adult; aged; anaplastic thyroid carcinoma; Article; bilateral salpingo-oophorectomy; bone metastasis; cancer diagnosis; cancer patient; case report; clinical article; cohort analysis; endometrioid carcinoma; exon; exon skipping; female; frameshift mutation; gene frequency; gene fusion; gene mutation; high throughput sequencing; histology; human; human tissue; immunohistochemistry; liver metastasis; lung adenocarcinoma; lung metastasis; lymph node dissection; lymph node metastasis; male; middle aged; missense mutation; molecularly targeted therapy; nonsense mutation; personalized medicine; pleura metastasis; positron emission tomography-computed tomography; sarcomatoid carcinoma; small cell lung cancer; splicing defect; total thyroidectomy; treatment planning; genetics; high throughput sequencing; lung tumor; non small cell lung cancer; pathology; procedures; retrospective study | English | 2022 | 2022 (MAY-JUN) | 10.21873/invivo.12844 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Comparison of Survival Outcomes According to BRCA1/2 Variant Type in High-grade Serous Ovarian Cancer | Background/Aim: Mutations of BRCA1/2 improve cancer prognosis due to their better response to platinum based chemotherapy. This study evaluated overall survival (OS) and progression-free survival (PFS) under similar conditions of first-line adjuvant chemotherapy within seven years in high-grade serous ovarian cancer (HGSOC). Patients and Methods: A total of 160 patients were enrolled. The pathogenic BRCA1/2 variant group included pathogenic variant and likely-pathogenic variant, while the nonpathogenic group included wild-type and variant of uncertain significance. For first-line chemotherapy, delivered dose intensity, relative dose intensity, and delay of duration were calculated in all patients. Results: Of the tested variants, 108 (67.5%) were non-pathogenic and 52 (32.5%) were pathogenic. No significant difference was found in various clinical factors of cancer stage, surgery, or chemotherapy. There was no significance for OS or PFS within five or seven years. Conclusion: In patients with HGSOC, the OS and PFS for germline BRCA1/2 pathogenic | Lee, Juhun; Kim, Jong Mi; Lee, Yoon Hee; Chong, Gun Oh; Lee, Nan Young; Lee, In Hee; Park, Ji Young; Hong, Dae Gy | Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Obstet & Gynecol, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Clin Pathol, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Hemato Oncol, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Pathol, Daegu, South Korea | LEE, SEJUE/KMX-1267-2024; lee, nan/HZM-0321-2023 | 57360628800; 57212764251; 37088851700; 23099068000; 57209204358; 57191881516; 57210160197; 26656670100 | dghong@knu.ac.kr; | IN VIVO | IN VIVO | 0258-851X | 1791-7549 | 36 | 4 | SCIE | MEDICINE, RESEARCH & EXPERIMENTAL | 2022 | 2.3 | 75.4 | 0 | 2025-06-25 | 0 | 0 | Key Words; BRCA1; 2 mutation; germline genetic mutation; ovarian cancer; chemotherapy; clinical outcomes; overall survival; progression-free survival | BRCA MUTATION; 10-YEAR SURVIVAL; FAMILIAL BREAST; WOMEN; FREQUENCY; GENE; CRITERIA; ALLELE | BRCA1/2 mutation; chemotherapy; clinical outcomes; germline genetic mutation; ovarian cancer; overall survival; progression-free survival | BRCA1 Protein; Chemotherapy, Adjuvant; Cystadenocarcinoma, Serous; Female; Humans; Mutation; Neoplasm Staging; Ovarian Neoplasms; bevacizumab; BRCA1 protein; BRCA2 protein; carboplatin; genomic DNA; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase inhibitor; pembrolizumab; protein variant; taxane derivative; BRCA1 protein; BRCA1 protein, human; add on therapy; adjuvant chemotherapy; adjuvant therapy; adult; Article; bilateral salpingo-oophorectomy; bioinformatics; cancer combination chemotherapy; cancer grading; cancer staging; cancer surgery; cancer survival; carcinogenesis; clinical outcome; colon cancer; comparative study; computer assisted tomography; DNA sequence; endometrium cancer; female; high throughput sequencing; human; hyperthermic intraperitoneal chemotherapy; International Federation of Gynecology and Obstetrics; Korea; lymph node dissection; major clinical study; neoadjuvant chemotherapy; nuclear magnetic resonance imaging; omentectomy; ovary cancer; overall survival; patient selection; peritoneum cancer; positron emission tomography; primary fallopian tube cancer; primary tumor; progression free survival; retrospective study; total hysterectomy; treatment duration; treatment response; cystadenocarcinoma; genetics; mutation; ovary tumor; pathology | English | 2022 | 2022 (JUL-AUG) | 10.21873/invivo.12910 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Drag reduction for flow past a square cylinder through corner chamfering | This study investigates the unsteady incompressible flow around a square cylinder with different chamfer ratios (CRs) using a commercial finite volume code, ANSYS Fluent. CR ranges from 0.0 (sharp square cylinder) to 0.5 (diamond cylinder) with variable increments. Detailed analysis of flow characteristics is conducted at Reynolds number (Re) = 2100. Additionally, simulation is extended to cover Re, i.e., Re = 100, 500, and 10000. The simulation results show that cylinder with CR = 0.1 outperforms all other cases by enabling a drag reduction of about 60 % at Re = 10(4). Drag has an inverse relationship with the wake closure length. Time-averaged coefficient of pressure, streamlines, and vorticity contours are also discussed to better understand near-wake features and the physics of drag reduction. | Nawaz, Muhammad Ahsan; Abubaker, Muhammad; Kumar, R. Ajith; Sohn, Chang-Hyun | Kyungpook Natl Univ, Dept Mech Engn, Daegu 41566, South Korea; Karachi Inst Econ & Technol, Dept Mechatron Engn, Karachi 75190, Pakistan; COMSATS Univ Islamabad, Dept Mech Engn, Sahiwal 57000, Pakistan; Amrita Vishwa Vidyapeetham, Dept Mech Engn, Amritapuri 690546, India | ; AJITH KUMAR, SILPA/AAI-6578-2021 | 57208018700; 56266743000; 57205383709; 36806852600 | chsohn@knu.ac.kr; | JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY | J MECH SCI TECHNOL | 1738-494X | 1976-3824 | 36 | 11 | SCIE | ENGINEERING, MECHANICAL | 2022 | 1.6 | 75.4 | 0.49 | 2025-06-25 | 4 | 6 | Chamfer ratios; Diamond cylinder; Drag reduction; Square cylinder | 2 CIRCULAR-CYLINDERS; ROUNDED CORNERS; UNSTEADY-FLOW; HEAT-TRANSFER; REYNOLDS; WAKE; SIMULATION; FORCES; RADIUS | Chamfer ratios; Diamond cylinder; Drag reduction; Square cylinder | Cylinders (shapes); Incompressible flow; Reynolds number; Wakes; Chamfer ratio; Diamond cylinder; Finite volume code; Flow around a square cylinder; Flow characteristic; Flow past a square cylinders; Fluents; Inverse relationship; Reynold number; Square cylinders; Drag reduction | English | 2022 | 2022-11 | 10.1007/s12206-022-1015-8 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Article | Effect of a large pulsed electron beam (LPEB) irradiation on mechanical properties and fatigue behavior of Ti-6Al-4V | The large pulsed electron beam (LPEB) is recently highlighted as a surface modification method of metallic alloys owing to various advantages such as high thermal gradient and fast processing speed compared to conventional surface treatments. Besides its effect on surface properties, the effect of LPEB irradiations of fatigue behavior of metallic alloys is yet to be explored. In this study, effects of the LPEB irradiation on fatigue behavior of Ti-6Al-4V titanium alloy were investigated. The mechanisms of changing fatigue characteristics were specified relating it with changes in physical properties such as hardness, surface roughness, phase transformation, and residual stress. © 2022, The Korean Society of Mechanical Engineers and Springer-Verlag GmbH Germany, part of Springer Nature. | Choe, Joon-Hyeok; Park, Sangwoo; Choe, Jung-Seob; Kim, Dong Min; Kim, Jisoo | Department of Precision Mechanical Engineering, Kyungpook National University (KNU), Sangju, 37224, South Korea; Dongnam Division, Korea Institute of Industrial Technology, Jinju, 52845, South Korea; Department of Precision Mechanical Engineering, Kyungpook National University (KNU), Sangju, 37224, South Korea; Dongnam Division, Korea Institute of Industrial Technology, Jinju, 52845, South Korea; Department of Precision Mechanical Engineering, Kyungpook National University (KNU), Sangju, 37224, South Korea, Department of Advanced Science and Technology Convergence, Kyungpook National University (KNU), Sangju, 37224, South Korea | 57660451700; 57733871000; 55285573500; 57203012563; 57192647685 | js.kim@knu.ac.kr;dmkim0707@kitech.re.kr; | Journal of Mechanical Science and Technology | J MECH SCI TECHNOL | 1738-494X | 1976-3824 | 36 | 6 | SCIE | ENGINEERING, MECHANICAL | 2022 | 1.6 | 75.4 | 0.25 | 2025-06-25 | 3 | Electron beam; Fatigue property; Residual stress; Surface treatment; Ti-6Al-4V | Electron beams; Fatigue of materials; Irradiation; Residual stresses; Surface roughness; Surface treatment; Ternary alloys; Titanium alloys; Vanadium alloys; Electron-beam; Fatigue behaviour; Fatigue properties; High thermal; Mechanical fatigue; Metallic alloys; Pulsed electron beam irradiation; Pulsed electron beams; Surface modification methods; Ti-6al-4v; Aluminum alloys | English | Final | 2022 | 10.1007/s12206-022-0523-x | 바로가기 | 바로가기 | 바로가기 | |||||||
| ○ | ○ | Article | Effect of Breast Silicone Implant Topography on Bacterial Attachment and Growth: An In Vitro Study | Background/Aim: The mechanisms underlying capsular contracture remain unclear. Emerging evidence supports the inflammation hypothesis, according to which bacteria from an adherent biofilm cause chronic inflammation and collagen deposition on the implant and trigger capsular contracture. Our goal was to evaluate the effect of different types of breast implants on the growth of Staphylococcus aureus, S. epidermidis, and Pseudomonas aeruginosa, which are commonly found in biofilms in infection. Materials and Methods: Bacteria were grown in tryptic soy broth at 37??C for 2, 6, and 24 h and subsequently incubated for 24 h on 12 shell sections of smooth, nano-, and macrotextured breast implants. After incubation, the solutions were ultrasonicated and bacterial numbers were determined by serial dilution. S. aureus were fixed, washed with phosphate-buffered saline, dehydrated in ethanol, and coated with a platinum film to visualize the presence of biofilms by scanning electron microscopy. Results: The numbers of S. aureus and S. epidermidis attached to the smooth and nanotextured surface implants were significantly | Lee, Jong Ho; Ryu, Jeong Yeop; Lee, Joon Seok; Choi, Kang Young; Chung, Ho Yun; Cho, Byung Chae; Kim, Koeun; Lee, Young Ju; Jin, Hee Kyung; Bae, Jae-Sung; Yang, Jung Dug | Kyungpook Natl Univ, Sch Med, Dept Plast & Reconstruct Surg, Daegu, South Korea; Kyungpook Natl Univ, Coll Vet Med, Daegu, South Korea; Kyungpook Natl Univ, Zoonoses Res Inst, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Physiol, Daegu, South Korea | Ryu, Jeong Yeop/GLQ-9419-2022; Kim, Jwa/AAH-9915-2021; Bae, Jae-sung/AAM-8663-2021; Kim, Young/T-8521-2019; Yang, Jung/R-7806-2019; LEE, JIN/Q-3108-2018 | 57212661146; 56366349400; 56496041000; 57203745682; 7404007181; 55662871100; 57220805028; 56612134500; 8088145800; 35209510400; 55171704700 | lambyang@hanmail.net; | IN VIVO | IN VIVO | 0258-851X | 1791-7549 | 36 | 4 | SCIE | MEDICINE, RESEARCH & EXPERIMENTAL | 2022 | 2.3 | 75.4 | 0.8 | 2025-06-25 | 10 | 10 | Key Words; Smooth breast implant; nano-textured breast implant; macrotextured breast implants; biofilm; breast implant infection; scanning electron microscopy | CAPSULAR CONTRACTURE; SURFACE-TOPOGRAPHY; AUGMENTATION; BIOFILMS; RELEVANCE; INFECTION | biofilm; breast implant infection; macrotextured breast implants; nano-textured breast implant; scanning electron microscopy; Smooth breast implant | Biofilms; Breast Implants; Contracture; Humans; Inflammation; Prosthesis Design; Silicones; Staphylococcus aureus; Staphylococcus epidermidis; Surface Properties; alcohol; phosphate buffered saline; platinum; silicone derivative; Article; bacterial count; bacterial growth; bacterial load; biofilm; broth dilution; clinical evaluation; colony forming unit; controlled study; in vitro study; incubation time; microbial activity; nonhuman; Pseudomonas aeruginosa; scanning electron microscopy; Staphylococcus aureus; Staphylococcus epidermidis; topography; adverse device effect; breast endoprosthesis; contracture; human; inflammation; prosthesis design; surface property | English | 2022 | 2022 (JUL-AUG) | 10.21873/invivo.12882 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Effects of Methylsulfonylmethane on UVB-induced Skin Damage: An Experimental Study in a Mouse Model | Background/Aim: The skin protects the body from ultraviolet rays and other external factors. Various studies have been conducted to identify methods to prevent skin aging and damage. To investigate the protective effects of methylsulfonylmethane (MSM), in this study, a hairless mouse model was used. Patients and Methods: Mice divided into Groups B, C, and D were subjected to UVB irradiation for six weeks, and Group A was considered the control. Retinoic acid is a substance that has been proven to have anti-aging properties. Group C was injected with MSM, group D was injected with retinoic acid, and groups A and B were injected with saline. At the end of the experiment, the degree of senescence was confirmed through visual evaluation, histopathological analysis, immunohistochemistry, and elasticity measurement using SEM. Results: After the end of the experiment, the wrinkle score was 0.4, 2.5, 1.8, 1.5 for Groups A, B, C, and D, respectively. Epidermal thickness was 40 mu m, 70 mu m, 60 mu m, 55 mu m in Groups A, B, C, and D, respectively. Group C showed less collagen confirmation loss and more angiogenesis and elastin precursor production. Elastic fiber linearity was 0.901 +/- 0.02, 0.551 +/- 0.04, 0.751 +/- 0.04, 0.822 +/- 0.03 for Groups A, B, C, and D, respectively. Conclusion: Injection of MSM in mice subjected to UVB-induced skin damage reduces the wrinkle score and protects against photoaging. | Chu, Seung Gyun; Chang, Yong June; Ryu, Jeong Yeop; Lee, Joon Seok; Choi, Kang Young; Chung, Ho Yun; Cho, Byung Chae; Yang, Jung Dug | Kyungpook Natl Univ, Sch Med, Dept Plast & Reconstruct Surg, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Plast & Reconstruct Surg, 130 Dongdeok ro, Daegu 41944, South Korea | Yang, Jung/R-7806-2019; Ryu, Jeong Yeop/GLQ-9419-2022; LEE, JIN/Q-3108-2018 | 57195774681; 57949685900; 56366349400; 56496041000; 57203745682; 7404007181; 55662871100; 55171704700 | lambyang@knu.ac.kr; | IN VIVO | IN VIVO | 0258-851X | 1791-7549 | 36 | 6 | SCIE | MEDICINE, RESEARCH & EXPERIMENTAL | 2022 | 2.3 | 75.4 | 0.27 | 2025-06-25 | 2 | 3 | Methylsulfonylmethane; UVB; antiaging; retinoic acid | WRINKLE FORMATION; RETINOIC ACID; MECHANISMS; ELECTRON; EFFICACY | antiaging; Methylsulfonylmethane; retinoic acid; UVB | Animals; Mice; Mice, Hairless; Skin; Skin Aging; Tretinoin; Ultraviolet Rays; dimethyl sulfone; fibrillin 1; skin protective agent; tropoelastin; dimethyl sulfone; retinoic acid; adult; animal experiment; animal model; animal tissue; antiaging activity; Article; controlled study; drug efficacy; epidermal thickness; follow up; histopathology; immunohistochemistry; male; Masson staining; micro-computed tomography; mouse; nonhuman; photoaging; scoring system; senescence; skin defect; ultraviolet B radiation; ultraviolet irradiation; adverse event; animal; cutaneous parameters; hairless mouse; skin; ultraviolet radiation | English | 2022 | 2022 (NOV-DEC) | 10.21873/invivo.13007 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Efficient dynamic behavior analysis of an adhesive-jointed structure made of composites | An inefficiency issue in substructure analysis is caused by a finite element model of an adhesive interface meshed into thousands of degrees of freedom. This paper presents a wave-approach based adhesive interface for efficient dynamic behavior analysis of a large adhesive jointed composite structure. The large adhesive interface is converted into a basis function known as waves. Orthonormalization selects the most important waves and reduces the interface size. Two engineering cases were presented. The predicted results obtained from the approach were compared with the full-size finite element and experimental counterparts to assess their accuracy level. It was discovered that the approach could significantly reduce the need for repeated long-term composite structure optimization analysis. | Basri, Ahmad Burhani Ahmad; Rani, Muhamad Norhisham Abdul; Lee, Hyeongill | Kyungpook Natl Univ, Sch Automot Engn, 2559 Gyeongsang Daero, Sangju 37224, Gyeongsangbuk D, South Korea; Univ Teknol MARA, Coll Engn, Struct Dynam Anal & Validat SDAV, Shah Alam 40450, Selangor, Malaysia | ; Ahmad Basri, Ahmad Burhani/AAX-5302-2021; Rani, Muhamad/AAS-3140-2020 | 57217176021; 55061632800; 8261483800 | hilee@knu.ac.kr; | JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY | J MECH SCI TECHNOL | 1738-494X | 1976-3824 | 36 | 4 | SCIE | ENGINEERING, MECHANICAL | 2022 | 1.6 | 75.4 | 0 | 2025-06-25 | 0 | 0 | Adhesive joint; Composite structure; Finite element method; Structural optimization; Substructuring synthesis; Wave-based substructuring | Adhesive joint; Composite structure; Finite element method; Structural optimization; Substructuring synthesis; Wave-based substructuring | Adhesive joints; Adhesives; Degrees of freedom (mechanics); Finite element method; Structure (composition); Adhesive interfaces; Composites structures; Dynamic behavior analysis; Finite element modelling (FEM); Structural optimisations; Sub-structuring; Substructure analysis; Substructuring synthesis; Wave-based substructuring; Structural optimization | English | 2022 | 2022-04 | 10.1007/s12206-022-0305-5 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Energy Efficiency Prediction Model of Heavy-duty Electric Vehicles Using Numerical Simulation | This paper is a study on energy efficiency prediction model of heavy-duty electric vehicles using numerical simulation. Because the current energy consumption efficiency evaluation method for electric vehicles has limitations in terms of manpower, resources, and time required, therefore a simulation model development to predict electric vehicle energy consumption efficiency is needed. Furthermore, research on heavy-duty electric vehicles is relatively insufficient compared to light-duty electric vehicles, and the need of research on heavy-duty electric vehicles is increasing. Therefore, this study develops an energy efficiency prediction model for heavy-duty electric vehicles and verifies it with the experimental results. Based on this, the applicability of the simulation method using the developed prediction model to the current energy efficiency evaluation management system for heavy-duty electric vehicles was reviewed. To verify the accuracy of the simulation model, the dynamometer test results were compared to simulation results, and the UDS protocol was used to acquire internal data for heavy-duty electric vehicles. Reliability of simulation model was secured by comparing data such as motor speed, battery voltage/current, state of charge and total driving distance of the test vehicles with data from the dynamometer experiment and the simulation model. | Song, Jingeun; Cha, Junepyo; Choi, Mingi | Kyungpook Natl Univ, Sch Automot Engn, Sangju 37224, South Korea; Korea Natl Univ Transportat, Dept Automot Engn, Chungju 27469, South Korea; Hanyang Cyber Univ, Sch Mech & Automot Engn, Seoul 04763, South Korea | Song, Jie/GLR-2301-2022 | 56714139600; 36237962800; 55800531800 | mgchoi@hycu.ac.kr; | INTERNATIONAL JOURNAL OF AUTOMOTIVE TECHNOLOGY | INT J AUTO TECH-KOR | 1229-9138 | 1976-3832 | 23 | 6 | SCIE | ENGINEERING, MECHANICAL;TRANSPORTATION SCIENCE & TECHNOLOGY | 2022 | 1.6 | 75.4 | 0.21 | 2025-06-25 | 2 | 3 | Heavy-duty electric vehicles; Energy efficiency; Numerical simulation; Multi cycle test; State of charge | Energy efficiency; Heavy-duty electric vehicles; Multi cycle test; Numerical simulation; State of charge | Battery management systems; Charging (batteries); Dynamometers; Energy utilization; Forecasting; Numerical models; Current energy; Efficiency evaluation; Efficiency predictions; Energy consumption efficiency; Heavy duty; Heavy-duty electric vehicle; Multi cycle tests; Prediction modelling; Simulation model; States of charges; Energy efficiency | English | 2022 | 2022-12 | 10.1007/s12239-022-0133-8 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Genomic Profiling of Aggressive Thyroid Cancer in Association With its Clinicopathological Characteristics | Background/Aim: Poorly differentiated thyroid carcinoma (PDTC), anaplastic thyroid carcinoma (ATC), and advanced DTC have poor outcomes. Materials and Methods: We performed next-generation sequencing in nine selected aggressive thyroid cancers. Results: Among the nine patients, the driver gene mutations BRAF V600E (3/9) and NRAS Q61K (1/9) were detected. Other oncogenic mutations included ERBB2 (1/9) and CDK4 (1/9). Telomerase reverse transcriptase (TERT) promoter mutation was found in five cases. Among tumor suppressor genes, mutations in TP53 (3/9), ARID1A (1/9), APC (1/9), MEN1 (1/9), DICER1 (1/9), and MED12 (1/9) were identified. RET fusions were found in two cases, one with PTDC and the other with ATC. The ATC with RET fusion also harbored TP53 and TERT promoter mutations. None of the PDTC cases had BRAF or RAS gene alterations. Conclusion: Since genetic alterations with therapeutic and prognostic implications were detected using next-generation sequencing, this technique is recommended to be performed for patients with aggressive thyroid cancer. | Kim, Jae-Hui; Jeong, Ji Yun; Seo, An Na; Park, Nora Jee-Young; Kim, Moonsik; Park, Ji Young | Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Pathol, Daegu, South Korea | 57416959900; 57205472984; 55804153700; 57226185359; 57195918515; 57210160197 | teiroa83@knuh.kr;jyparkmd@knu.ac.kr; | IN VIVO | IN VIVO | 0258-851X | 1791-7549 | 36 | 1 | SCIE | MEDICINE, RESEARCH & EXPERIMENTAL | 2022 | 2.3 | 75.4 | 0.89 | 2025-06-25 | 8 | 10 | Whole exome sequencing; next-generation sequencing; aggressive thyroid cancer; anaplastic thyroid carcinoma; poorly differentiated thyroid carcinoma; advanced differentiated thyroid cancer | POORLY DIFFERENTIATED CARCINOMA; THERAPEUTIC TARGET; MOLECULAR-GENETICS; MATCHED PRIMARY; MUTATIONS; BRAF; IDENTIFICATION; HETEROGENEITY; LANDSCAPE; DIAGNOSIS | Advanced differentiated thyroid cancer; Aggressive thyroid cancer; Anaplastic thyroid carcinoma; Next-generation sequencing; Poorly differentiated thyroid carcinoma; Whole exome sequencing | DEAD-box RNA Helicases; Genomics; Humans; Mutation; Proto-Oncogene Proteins B-raf; Ribonuclease III; Telomerase; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; APC protein; B Raf kinase; cyclin dependent kinase 4; dicer; DICER1 protein; epidermal growth factor receptor 2; MED12 protein; MEN1 protein; protein p53; protein Ret; Ras protein; retinoblastoma binding protein 2; telomerase reverse transcriptase; tumor suppressor protein; unclassified drug; B Raf kinase; DEAD box protein; DICER1 protein, human; ribonuclease III; telomerase; adult; advanced cancer; aged; anaplastic thyroid carcinoma; Article; cancer patient; clinical article; cohort analysis; controlled study; differentiated thyroid cancer; female; gene identification; gene mutation; genetic profile; high throughput sequencing; human; human tissue; lymph node metastasis; male; middle aged; molecular pathology; poorly differentiated thyroid cancer; promoter region; retrospective study; thyroid adenoma; thyroid cancer; thyroid papillary carcinoma; tumor suppressor gene; whole exome sequencing; genetics; genomics; mutation; thyroid carcinoma; thyroid tumor | English | 2022 | 2022 (JAN-FEB) | 10.21873/invivo.12682 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Investigation of constantly and transiently propagating cracks in functionally graded materials by dynamic photoelasticity | In this study, the stress intensity factors (SIFs) for steady and transient propagation of cracks in transparent homogeneous functionally graded materials were analyzed by using the photoelasticity technique. The fracture analysis was carried out for the cracks propagating from a region with high elasticity towards low elasticity, as well as the cracks propagating from a region with low elasticity towards high elasticity. The analysis includes cracks propagating (1) at an almost steady speed, and (2) with the rapid increase, followed by a decrease in speed. For cracks with almost constant velocity, the SIFs were greater when a crack started from a high elasticity region, as compared to the cracks which initiated from a low elasticity region. For cracks propagating with rapid acceleration and deceleration, when the strain energy accumulated in the material due to an increase in load or stress was released at the moment of crack propagation, the SIF was momentarily lowered by approximately 45 %-50 % of the static SIF(before crack initiation), which subsequently increases by approximately 30 % eventually, the crack acceleration approaches nearly zero; the SIF decreases and increases respectively as the crack propagates in a material with decreasing and increasing modulus of elasticity. | Lee, Kwang Ho; Kidane, Addis; Shukla, Arun | Kyungpook Natl Univ, Sch Automot Engn, 2559 Gyeongsangdaero, Sangju, South Korea; Univ South Carolina, Dept Mech Engn, 300 Main St, Columbia, SC 29208 USA; Univ Rhode Isl, Dept Mech Ind & Syst Engn, Dynam Photo Mech Lab, Kingston, RI 02881 USA | 56348794600; 23667688800; 7202963299 | khl@knu.ac.kr; | JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY | J MECH SCI TECHNOL | 1738-494X | 1976-3824 | 36 | 9 | SCIE | ENGINEERING, MECHANICAL | 2022 | 1.6 | 75.4 | 0.16 | 2025-06-25 | 1 | 2 | Constantly propagating crack; Transiently propagating crack; Dynamic stress intensity factors; Functionally gradient materials; Nonhomogeneous elastic parameter; Nonhomogeneous stress fringe parameter; Photoelasticity | FRACTURE-ANALYSIS; INTERFACE; GROWTH | Constantly propagating crack; Dynamic stress intensity factors; Functionally gradient materials; Nonhomogeneous elastic parameter; Nonhomogeneous stress fringe parameter; Photoelasticity; Transiently propagating crack | Crack propagation; Elasticity; Functionally graded materials; Physical optics; Strain energy; Stress intensity factors; Constantly propagating crack; Dynamic stress intensity factors; Elastic parameters; Fringe parameters; Functionally gradient materials; Non-homogeneous; Nonhomogeneous elastic parameter; Nonhomogeneous stress fringe parameter; Stress fringe; Transiently propagating crack; Photoelasticity | English | 2022 | 2022-09 | 10.1007/s12206-022-0808-0 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Long-term Experience of Single-port and Multi-port Total Laparoscopic Hysterectomy in a Single Center | Background/Aim: Short-term feasibility and safety of single-port total laparoscopic hysterectomy (TLH) compared with conventional multi-port TLH have been previously demonstrated. However, recent studies are insufficient. This study aimed to analyze long-term data from our center to examine the current status of single-port and multi-port TLH.Patients and Methods: In 766 patients who received TLH from 2005 to 2019, 325 were single-port and 441 were multi-port. Inclusion criteria were benign and premalignant uterine diseases. To reduce the impact of treatment selection bias and potential confounding factors, inverse probability of treatment weighting was applied. Results: Single-port TLH showed significantly better clinical outcomes for hospital stay, operative time, hemoglobin decrease, and complication rate than the multi-port TLH after correction of biases. C-reactive protein increased after the single-port TLH. Conclusion: As laparoscopic surgical instruments and surgeon's skill have been improved, some surgical outcomes have become significantly better in single -port TLH after long-term observation. | Lee, J. U. H. U. N.; Lee, Yoon Soon; Hong, Dae Gy | Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Obstet & Gynecol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Obstet & Gynecol, 680 Gukchaebosang-ro, Daegu 41944, South Korea | 57360628800; 57931706900; 26656670100 | dghong@knu.ac.kr; | IN VIVO | IN VIVO | 0258-851X | 1791-7549 | 36 | 5 | SCIE | MEDICINE, RESEARCH & EXPERIMENTAL | 2022 | 2.3 | 75.4 | 0.27 | 2025-06-25 | 3 | 3 | Minimally invasive surgery; laparoscopic hysterectomy; benign uterine disease; single-site laparoscopy; inverse probability of treatment weighting | SITE SURGERY; METAANALYSIS; TROCAR | benign uterine disease; inverse probability of treatment weighting; laparoscopic hysterectomy; Minimally invasive surgery; single-site laparoscopy | Female; Humans; Hysterectomy; Laparoscopy; Length of Stay; Operative Time; C reactive protein; hemoglobin; adult; Article; bladder injury; bleeding; clinical outcome; confounding variable; endometrium hyperplasia; female; hospitalization; human; intermethod comparison; intestine; laparoscopic hysterectomy; laparoscopic surgery; laparoscopy; length of stay; major clinical study; minimally invasive surgery; operation duration; outcome assessment; perioperative complication; probability; retrospective study; selection bias; skill; surgeon; surgical infection; treatment indication; treatment outcome; ureter injury; uterine cervix dysplasia; uterus disease; uterus myoma; vaginal injury; work experience; adverse event; hysterectomy; laparoscopy | English | 2022 | 2022 (SEP-OCT) | 10.21873/invivo.12974 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Patterns-Based Coating of Piston Skirt for Added Benefits during Hydrodynamic Lubrication in Internal Combustion Engines | Friction has been a significant research concern for decades. Most of the energy input into an internal combustion (IC) engine is wasted because it is used to overcome friction. Scientific developments have been made to reduce friction, including surface coatings and surface textures, which have emerged as potential solutions to reducing friction throughout the lubricating regimes. This study combines surface texturing with the coating approach to investigate the frictional response. Realistic tribo-dynamics (secondary motion of the piston skirt) are considered during actual engine-like conditions to explore the effects of pattern-based coating on friction in hydrodynamic lubrication. Results show a remarkable reduction in friction and encourage the pattern-based development of surface coatings to extend the benefit across lubricating regimes. Consequently, the surface coated with optimized patterns had 7.98 +/- 0.34 % reduced energy loss per engine cycle as compared with the surface coated without a pattern. | Usman, Ali; Liwicki, Marcus; Almqvist, Andreas; Park, Cheol Woo | Lulea Univ Technol, Div Machine Learning, S-97187 Lulea, Sweden; COMSATS Univ Islamabad, Dept Mech Engn, Islamabad 47040, Pakistan; Lulea Univ Technol, Div Machine Elements, S-97187 Lulea, Sweden; Kyungpook Natl Univ, Sch Mech Engn, Daegu 41566, South Korea | Almqvist, Andreas/GYR-3923-2022 | 42062484500; 14021418000; 8367337400; 7408416474 | chwoopark@knu.ac.kr; | INTERNATIONAL JOURNAL OF AUTOMOTIVE TECHNOLOGY | INT J AUTO TECH-KOR | 1229-9138 | 1976-3832 | 23 | 4 | SCIE | ENGINEERING, MECHANICAL;TRANSPORTATION SCIENCE & TECHNOLOGY | 2022 | 1.6 | 75.4 | 0.14 | 2025-06-25 | 2 | 2 | Tribological performance; Surface coatings; Surface texture; piston skirt; Secondary motion | MIXED LUBRICATION; FRICTION; BEHAVIOR; LINER; RING | piston skirt; Secondary motion; Surface coatings; Surface texture; Tribological performance | Coatings; Combustion; Energy dissipation; Hydrodynamics; Internal combustion engines; Piston rings; Pistons; Textures; Tribology; Energy inputs; Hydrodynamic lubrication; Lubricating regime; Piston skirts; Scientific development; Secondary motion; Surface coated; Surface coatings; Surface textures; Tribological performance; Friction | English | 2022 | 2022-08 | 10.1007/s12239-022-0096-9 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Process design of multi-stage cold forging with small size for ESC solenoid valve parts | ESC's solenoid valves independently brake each wheel, allowing the vehicle to maintain braking and directional stability. The most important component of the solenoid valve is the armature manufactured by the turning process by a CNC lathe so far. In this study, we propose to use the multi-stage cold forging process as an alternative to reduce manufacturing cost while satisfying dimensional accuracy and performance. To apply the multi-stage cold forging process, the whole forming process is divided into six stages to improve the dimensional accuracy of the outer diameter, full length and slot part of the armature. It is divided into 6 stages, but 6 stages are operated simultaneously in one stroke of forging. Inducing uniform plastic deformation by designing the preform for each stage of the armature slot. Through the proposed process design for the multi-stage cold forging process, the dimensional accuracy of the test product can be improved. The weight of the input material in the turning process can be reduced by 46 % from 3.5 g to 1.9 g by applying the multi-stage cold forging process. In addition, the manufacturing process can be reduced from 2 processes to 1 process, and the production quantity can be increased by 2500 % from 180 ea to 4800 ea per hour. | Lee, Hak-Sun; Park, Sang-Gyun; Hong, Myoung-Pyo; Kim, Young-Suk | SUNGJIN FO MA Inc, R&D Ctr, 93 Dalseodaero 109 Gil, Daegu, South Korea; Kyungpook Natl Univ, Grad Sch, 80 Daehak Ro, Daegu, South Korea; Korea Inst Ind Technol, Mech Components & Mat R&D Grp, 320 Techno Sunhwan Ro, Daegu, South Korea; Kyungpook Natl Univ, Sch Mech Engn, BO Daehak Ro, Daegu, South Korea | Kim, Sang-Hoon/AAA-2248-2020 | 57192280260; 57238449000; 57192270657; 36065820800 | caekim@knu.ac.kr; | JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY | J MECH SCI TECHNOL | 1738-494X | 1976-3824 | 36 | 1 | SCIE | ENGINEERING, MECHANICAL | 2022 | 1.6 | 75.4 | 0.49 | 2025-06-25 | 4 | 6 | Armature; Electronic stability control; Multi-stage cold forging; Reduce manufacturing cost; Solenoid valve | VEHICLE; SYSTEM; NET; SIMULATION; PLATE; MODEL | Armature; Electronic stability control; Multi-stage cold forging; Reduce manufacturing cost; Solenoid valve | Automobile manufacture; Cost reduction; Process design; Product design; Solenoids; Turning; Armature; Cold forging; Cold forging process; Dimensional accuracy; Electronic stability control; Manufacturing cost; Multi-stage cold forging; Multi-stages; Reduce manufacturing cost; Turning process; Solenoid valves | English | 2022 | 2022-01 | 10.1007/s12206-021-1235-3 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Survival Outcomes With Reduced Doses of Adjuvant Chemotherapy in Advanced Epithelial Ovarian Cancer | Background/Aim: There have not been enough recent studies investigating the incidence or efficacy of dose reduction in adjuvant chemotherapy for epithelial ovarian cancer. This study examined whether patients who needed dose reduction showed poorer survival outcomes. Patients and Methods: From 2011 to 2021, 102 patients were included in the study. Patients who underwent neoadjuvant chemotherapy and those with early-stage disease were excluded. Patients were divided into two groups: those who had a 60%. Of the 102 patients, 38 (37.3%) underwent dose reduction 60%. Results: PFS was significantly longer in the group whose dose reductions were >60%, whereas OS was not significant. Conclusion: A dose reduction of >60%, determined by patients??? medical conditions, during first-line of adjuvant chemotherapy does not negatively influence survival outcomes, such as OS and PFS, in advanced epithelial ovarian cancer. | Lee, Juhun; Kim, Jong Mi; Lee, Yoon Hee; Chong, Gun Oh; Hong, Dae Gy | Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Obstet & Gynecol, Daegu, South Korea | LEE, SEJUE/KMX-1267-2024 | 57360628800; 57212764251; 37088851700; 23099068000; 26656670100 | dghong@knu.ac.kr; | IN VIVO | IN VIVO | 0258-851X | 1791-7549 | 36 | 4 | SCIE | MEDICINE, RESEARCH & EXPERIMENTAL | 2022 | 2.3 | 75.4 | 0.18 | 2025-06-25 | 2 | 2 | Chemotherapy; clinical outcomes; dose reduction; ovarian cancer; overall survival; progression-free survival | CARBOPLATIN; PACLITAXEL; REDUCTIONS; INTENSITY; REGIMENS; DELAYS | Chemotherapy; clinical outcomes; dose reduction; ovarian cancer; overall survival; progression-free survival | Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Ovarian Epithelial; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Humans; Neoadjuvant Therapy; Neoplasm Staging; Ovarian Neoplasms; Retrospective Studies; bevacizumab; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase inhibitor; pembrolizumab; antineoplastic agent; adult; advanced cancer; Article; cancer adjuvant therapy; cancer patient; cancer survival; clinical outcome; controlled study; drug dose reduction; drug efficacy; female; human; major clinical study; middle aged; ovary carcinoma; overall response rate; overall survival; progression free survival; retrospective study; survival rate; survival time; adjuvant chemotherapy; cancer staging; disease free survival; drug therapy; neoadjuvant therapy; ovary tumor; pathology | English | 2022 | 2022 (JUL-AUG) | 10.21873/invivo.12905 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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