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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Persimmon (Diospyros kaki Thunb.) seed: a potential nutritional source with antioxidant and pharmaceutical activity | Pulp is a major part of persimmon fruit, for which it is widely cultivated in different parts of the world. Persimmon seeds are generally discarded as waste. The objective of the present work was to investigate the nutritional, antioxidative, and pharmacological properties of the seeds of three persimmon cultivars namely Jinyeong (JYS), Yangyangdongchulsi (YYS), and Hamanmulgam (HAS). JYS (9417.87 mg.kg(-1)) contained the highest concentration of total minerals, followed by HAS and YYS. The concentration of total organic acids was also the highest in JYS (5362.43 mg.kg(-1)), while the lowest in HAS (4411.1 mg.kg(-1)). Similarly, JYS and YYS contained the highest and lowest concentrations of free sugars, respectively. On the other hand, the total free amino acid contents were the highest in YYS (336.34 mg.100 g(-1)) among the cultivars. The persimmon seeds also have good potential for scavenging free radicals and inhibiting acetylcholinesterase activity. The seeds could also be considered to be a source of a therapeutic agent against Alzheimer's disease, as the seed extract showed promising anti-acetylcholinesterase activity. The overall results of the present work provide an insight into persimmon seeds, a by-product of persimmon fruit, as a potential product in the pharmaceutical and food industries. (C) All Rights Reserved | Han, C. H.; Kim, I. D.; Kwon, S. I.; Dhungana, S. K.; Jang, S. Y.; Kim, M. J.; Shin, D. H. | Kyungpook Natl Univ, Sch Appl Biosci, Daegu 41566, South Korea; Kyungpook Natl Univ, Int Inst Agr Res & Dev, Daegu 41566, South Korea; Daegu Hlth Coll, Dept Clin Pathol, Daegu 41453, South Korea; Rural Dev Adm, Natl Inst Crop Sci, Miryang 50424, South Korea | Dhungana, Sanjeev Kumar/O-4097-2017 | 57225786002; 56269995600; 57221848852; 56269940800; 59884390800; 57127351600; 7403352903 | dhshin@knu.ac.kr; | INTERNATIONAL FOOD RESEARCH JOURNAL | INT FOOD RES J | 1985-4668 | 2231-7546 | 27 | 6 | SCIE | FOOD SCIENCE & TECHNOLOGY | 2020 | 1.014 | 87.1 | 0 | 2025-06-25 | 0 | 0 | antioxidant; free radical scavenger; nutrition; nutraceutical; persimmon seed | AMINO-ACIDS; PHENOLIC-COMPOUNDS; ORGANIC-ACIDS; EXTRACTS; METABOLISM; HEALTH; FRUITS; ASSAY | free radical scavenger; nutraceutical; nutrition; persimmon seed | English | 2020 | 2020-12 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | A robust approach for testing parameter change in Poisson autoregressive models | Parameter change test has been an important issue in time series analysis. The problem has also been actively explored in the field of integer-valued time series, but the testing in the presence of outliers has not yet been extensively investigated. This study considers the problem of testing for parameter change in Poisson autoregressive models particularly when observations are contaminated by outliers. To lessen the impact of outliers on testing procedure, we propose a test based on the density power divergence, which is introduced by Basu et al. (Biometrika 85:549-559, 1998), and derive its limiting null distribution. Monte Carlo simulation results demonstrate validity and strong robustness of the proposed test. | Kang, Jiwon; Song, Junmo | Jeju Natl Univ, Dept Comp Sci & Stat, Jeju, South Korea; Kyungpook Natl Univ, Dept Stat, Daegu, South Korea | 56123620200; 23470710200 | jsong@knu.ac.kr; | JOURNAL OF THE KOREAN STATISTICAL SOCIETY | J KOREAN STAT SOC | 1226-3192 | 2005-2863 | 49 | 4 | SCIE | STATISTICS & PROBABILITY | 2020 | 0.805 | 87.6 | 0.7 | 2025-06-25 | 6 | 6 | Testing for parameter change; Poisson AR model; Outliers; Robust test; Density power divergence | TIME-SERIES | Density power divergence; Outliers; Poisson AR model; Robust test; Testing for parameter change | English | 2020 | 2020-12 | 10.1007/s42952-020-00056-7 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Objective Bayesian analysis using modified profile likelihood for the ratio of two log-normal means | Matching priors in principle provide a possible compromise between frequentist and Bayesian and default priors for routine use in Bayesian inference in that posterior probability of the parameter also provides an interpretation as confidence statements. Here we introduce a matching prior for the ratio of two log-normal means which is nontrivial because the derivation of matching prior requires the elicitation of a suitable orthogonal parameterization on the nuisance parameters and the computation of the marginal posterior distribution requires multidimensional integration over the nuisance parameter. Numerical integrations and approximation techniques could be used but they are difficult to use in general. Thus, we derive a matching prior based on a modification of the profile likelihood to avoid the elicitation of priors for the entire parameter and integration on the nuisance parameter. The proposed method is illustrated by real data examples and simulation studies under several configurations. | Kang, Sang Gil; Lee, Woo Dong; Kim, Yongku | Sangji Univ, Dept Comp & Data Informat, Wonju 18950, South Korea; Daegu Haany Univ, Dept Cosmeceut Engn, Kyungsan 38610, South Korea; Kyungpook Natl Univ, Dept Stat, Daegu 41566, South Korea | 56119861400; 8328822200; 47962102500 | sangkg@sangji.ac.kr;wdlee@dhu.ac.kr;kim.1252@knu.ac.kr; | JOURNAL OF THE KOREAN STATISTICAL SOCIETY | J KOREAN STAT SOC | 1226-3192 | 2005-2863 | 49 | 2 | SCIE | STATISTICS & PROBABILITY | 2020 | 0.805 | 87.6 | 0.14 | 2025-06-25 | 4 | 1 | Matching prior; Modified profile likelihood; Ratio of log-normal means | DISTRIBUTIONS; INFERENCE | Matching prior; Modified profile likelihood; Ratio of log-normal means | English | 2020 | 2020-06 | 10.1007/s42952-019-00028-6 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Self-semi-supervised clustering for large scale data with massive null group | In this paper, we propose self-semi-supervised clustering, a new clustering method for large scale data with a massive null group. Self-semi-supervised clustering is a two-stage procedure: preselect a part of "null" group from the data in the first stage and apply semi-supervised clustering to the rest of the data in the second stage, allowing them to be assigned to the null group. We evaluate the performance of the proposed method using a simulation study and demonstrate the method in the analysis of time course gene expression data from a longitudinal study of Influenza A virus infection. | Ahn, Soohyun; Choi, Hyungwon; Lim, Johan; Lee, Kyeong Eun | Ajou Univ, Dept Math, Suwon, South Korea; Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore, Singapore; Seoul Natl Univ, Dept Stat, Seoul, South Korea; Kyungpook Natl Univ, Dept Stat, Daegu, South Korea | Choi, Hyungwon/KVX-7893-2024 | 55040601100; 14065669100; 16401812900; 56041259000 | johanlim@snu.ac.kr; | JOURNAL OF THE KOREAN STATISTICAL SOCIETY | J KOREAN STAT SOC | 1226-3192 | 2005-2863 | 49 | 1 | SCIE | STATISTICS & PROBABILITY | 2020 | 0.805 | 87.6 | 0.28 | 2025-06-25 | 3 | 2 | Massive null group; Model-based clustering; Pre-selection; Semi-supervised clustering; Time-course microarray data; Influenza A virus | MODEL; EXPRESSION; REGRESSION; FEATURES | Influenza A virus; Massive null group; Model-based clustering; Pre-selection; Semi-supervised clustering; Time-course microarray data | English | 2020 | 2020-03 | 10.1007/s42952-019-00005-z | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | FoxP3, PD-1 and CTLA-4 are decreased significantly after a tenofovir therapy in patients with chronic hepatitis B | Background: FoxP3, PD-1 and CTLA-4 are upregulated in chronic viral infections, such as chronic HCV, chronic HBV and HIV infection. Materials & methods: During 1 year of tenofovir disoproxil fumarate (TDF) treatment in patients with chronic hepatitis B, we investigated the expression of FoxP3, PD-1 and CTLA-4. Peripheral blood mononuclear cells were isolated from the 30 study subjects at T0 (0 months), T3, T6 and T12 months after the commencement of TDF treatment. Results & conclusion: Expression of FoxP3, PD-1 and CTLA-4 was significantly decreased in T cells of patients with chronic hepatitis B under TDF treatment at T12, when compared with that at T0. A direct correlation was observed between FoxP3 and CTLA-4 expression in patients with chronic hepatitis B and the frequency of FoxP3 was positively associated with serum alanine aminotransferase levels. | Cho, Hyosun; Kang, Hyojeung; Kim, Ji Y.; Kim, Hee Y.; Kim, Chang W. | Duksung Womens Univ, Dept Pharm, Coll Pharm, Seoul, South Korea; Duksung Womens Univ, Dept Pharm, Duksung Innovat Drug Ctr, Seoul, South Korea; Kyungpook Natl Univ, Coll Pharm, Dept Pharm, Res Inst Pharmaceut Sci, Daegu, South Korea; Kyungpook Natl Univ, Inst Microorganisms, Daegu, South Korea; Catholic Univ Korea, Dept Internal Med, Coll Med, Seoul, South Korea | Kim, Chang/G-5001-2015 | 55572361200; 8979751700; 57219030945; 7410124185; 57212853555 | hyosun1102@duksung.ac.kr;cwkim@catholic.ac.kr; | FUTURE VIROLOGY | FUTURE VIROL | 1746-0794 | 1746-0808 | 15 | 4 | SCIE | VIROLOGY | 2020 | 1.831 | 87.8 | 0.05 | 2025-06-25 | 2 | 2 | CTLA-4; FoxP3; HBV; PD-1; tenofovir | REGULATORY T-CELLS; VIRUS INFECTION; EXPRESSION; HBV; INDUCTION; PATHWAYS; DISEASE; IMPACT | CTLA-4; FoxP3; HBV; PD-1; tenofovir | alanine aminotransferase; cytotoxic T lymphocyte antigen 4; programmed death 1 ligand 1; tenofovir disoproxil; transcription factor FOXP3; adult; aged; alanine aminotransferase blood level; antiviral therapy; Article; CD4+ T lymphocyte; CD8+ T lymphocyte; cell isolation; chronic hepatitis B; clinical article; controlled study; female; flow cytometry; human; human cell; immunophenotyping; male; patient compliance; peripheral blood mononuclear cell; priority journal; protein expression level; regulatory T lymphocyte; treatment duration; upregulation; virus replication | English | 2020 | 2020-04 | 10.2217/fvl-2019-0128 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | High yield recombinant expression and purification of oncogenic NSD1, NSD2, and NSD3 with human influenza hemagglutinin tag | The nuclear receptor-binding SET Domain (NSD) family consists of NSD1, NSD2/MMSET/WHSC1, and NSD3/WHSC1L1 histone methyltransferases that are crucial for chromatin remodeling. NSDs are implicated in developmental disorders such as Wolf-Hirschhorn and Sotos syndromes as well as various cancers including t(4; 14)(p16; q32) myeloma, an incurable cancer in plasma cells. NSDs have been the target of intensive study to understand their biological functions more fully and inform anti-cancer drug design. Recombinant protein expression and purification of human NSDs using an E. coli expression system are notoriously challenging, but the production of pure, stable, and active NSDs is essential for further studies. To overcome production challenges, we propose a cost-efficient approach optimized to produce a high yield of NSDs using a modified E. coli expression system. We found that tagging the NSDs with a human influenza hemagglutinin (HA) tag greatly improved the quality of the recombinant NSDs, resulting in more than 95% pure, stable, and active NSD-HAs, with an increase in production yield up to 22.4-fold and up to 6.25 mg/L from LB E. coli culture, and without further purification such as ion-exchange or size-exclusion chromatography. | Shen, Yunpeng; Morishita, Masayo; di Luccio, Eric | Kyungpook Natl Univ, Coll Nat Sci, Sch Life Sci, Dept Genet Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, Coll Agr & Life Sci, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Kyungpook Natl Univ, Inst Agr Sci & Technol, Daegu 41566, South Korea | di Luccio, Eric/Z-5388-2019 | 57189042113; 46261422200; 6602656101 | masayo.morishita.dl@gmail.com;eric.diluccio@gmail.com; | PROTEIN EXPRESSION AND PURIFICATION | PROTEIN EXPRES PURIF | 1046-5928 | 1096-0279 | 166 | SCIE | BIOCHEMICAL RESEARCH METHODS;BIOCHEMISTRY & MOLECULAR BIOLOGY;BIOTECHNOLOGY & APPLIED MICROBIOLOGY | 2020 | 1.65 | 87.8 | 0.21 | 2025-06-25 | 5 | 4 | NSD1; NSD2; NSD3; HA-tag; Recombinant expression; Escherichia coli | GENE; WHSC1L1 | Escherichia coli; HA-tag; NSD1; NSD2; NSD3; Recombinant expression | Amino Acid Sequence; Chromatography, Ion Exchange; Escherichia coli; Gene Expression; Genetic Vectors; Hemagglutinin Glycoproteins, Influenza Virus; Histone-Lysine N-Methyltransferase; Humans; Intracellular Signaling Peptides and Proteins; Protein Conformation; Protein Stability; Recombinant Proteins; histone lysine methyltransferase; Influenza virus hemagglutinin; recombinant protein; signal peptide; amino acid sequence; chemistry; enzymology; Escherichia coli; gene expression; gene vector; genetics; human; ion exchange chromatography; protein conformation; protein stability | English | 2020 | 2020-02 | 10.1016/j.pep.2019.105506 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Effect of La0.8Ca0.2Cr0.9Co0.1O3-δ infiltration on the LCCC-YSZ layer as an interconnector material in solid oxide fuel cells | Full densification of the interconnector La0.8Ca0.2Cr0.9Co0.1O3-delta (LCCC) layer is hardly achieved when it is screen-printed and cofired on a pre-sintered NiO-YSZ (yttria-stabilized zirconia, 8YSZ) substrate. In this study, the LCCC precursors with different concentrations and viscosities were prepared and infiltrated into the LCCC-YSZ layer. The phase development process and densification behavior of the LCCC were analyzed, and the optimum conditions for full densification are suggested. Through the research, we propose a method for manufacturing a dense LCCC interconnector layer. | Lee, Ho-Chang; Lee, Jiwon; Lee, Jung-A; Heo, Young-Woo; Lee, Joon-Hyung; Kim, Jeong-Joo | Kyungpook Natl Univ, Sch Mat Sci & Engn, Daegu 41566, South Korea | Lee, Jung/AAP-7829-2021; Kim, Jihyun/F-6940-2013 | 55085509700; 55780416700; 55108410500; 7004298542; 57204923460; 8214705700 | joonlee@knu.ac.kr;jjkim@knu.ac.kr; | JOURNAL OF CERAMIC PROCESSING RESEARCH | J CERAM PROCESS RES | 1229-9162 | 21 | 2 | SCIE | MATERIALS SCIENCE, CERAMICS | 2020 | 0.69 | 87.9 | 0 | 2025-06-25 | 2 | 1 | Sintering; Ceramics; Interconnector; Sol-gel preparation; Infiltration | STAINLESS-STEEL SUBSTRATE; DOPED LANTHANUM CHROMITE; COATING LAYER | Ceramics; Infiltration; Interconnector; Sintering; Sol-gel preparation | English | 2020 | 2020-04 | 10.36410/jcpr.2020.21.2.208 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Effects of Oral Gargling with Aroma Solution in Psychiatric Inpatients: A Non-Randomized Controlled Trial | Purpose: The purpose of this study was to examine the effects of oral gargling with an aromatic solution on xerostomia, objective oral status, and oral health-related quality of life in psychiatric inpatients. Methods: A nonequivalent control group with a non-synchronized design was used in this study. The experimental group (n=34) received oral gargling with an aroma solution, while the control group (n=33) gargled with 0.9% normal saline. Dependent variables were measured at pre-, post-, and follow-up test. Data were analyzed using an chi(2)-test, Fisher's exact probability test, t-tests, and repeated measures ANOVA using SPSS/WIN v.21.0. Results: After the intervention, significant differences were revealed in xerostomia (F=15.30, p<.001), objective oral status (F=38.44, p<.001), and oral health-related quality of life (F=62.70, p<.001) with an interaction effect between group and time. Conclusion: These findings indicate that gargling with an aroma solution is more effective than 0.9% normal saline for the oral health of psychiatric inpatients. Therefore gargling with an aroma can be safely recommended as a brief, economical, and positive intervention in clinical settings. | Jung, Yun Ah; Kim, Hee Sook | Kyungpook Natl Univ, Coll Nursing, Daegu, South Korea; Kyungpook Natl Univ, Res Inst Nursing Sci, Coll Nursing, 680 Gukchaebosang Ro, Daegu 41944, South Korea | Kim, Cheol-Hee/F-6278-2013 | 57216672367; 58668801200 | hskim4114@nate.com; | JOURNAL OF KOREAN ACADEMY OF NURSING | J KOREAN ACAD NURS | 2005-3673 | 2093-758X | 50 | 2 | SCIE;SSCI | NURSING | 2020 | 0.984 | 88.1 | 0.18 | 2025-06-25 | 1 | 1 | Aromatherapy; Psychiatry; Inpatients; Xerostomia; Oral Health | ESSENTIAL OIL; MOUTH CARE; HEALTH | Aromatherapy; Inpatients; Oral Health; Psychiatry; Xerostomia | Adult; Aromatherapy; Female; Humans; Male; Mental Disorders; Middle Aged; Mouthwashes; Oral Health; Quality of Life; Surveys and Questionnaires; Xerostomia; Young Adult; mouthwash; adult; aromatherapy; chemistry; controlled clinical trial; controlled study; female; health; human; male; mental disease; middle aged; pathology; psychology; quality of life; questionnaire; xerostomia; young adult | Korean | 2020 | 2020-04 | 10.4040/jkan.2020.50.2.200 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Qualitative Study on the Experience of Patients with Meniere Disease | Purpose: The purpose of this study was to understand and describe the experiences of patients with Meniere disease. Methods: Data were collected from February 19, 2019, to February 5, 2020, through individual in-depth interviews with 13 Meniere patients. Verbatim transcripts were analyzed using Colaizzi's phenomenological analysis. Results: The experiences of patients with Meniere disease were clustered into the following four themes from 22 meaning units: 1) Complex unfamiliar symptoms that shatter both balance of the body and peace of the heart; 2) A disease that medical treatment and health professionals cannot cure; 3) Suffering hardships that cannot be understood by non-Meniere sufferers; and 4) Making daily efforts to become healthier. Symptoms of Meniere disease are life-shattering and depressing because they are neither visible nor easily curable. Over time, as they accepted the reality of living with the disease, the participants would shift their focus from complete symptomatic cure to leading a healthy and more balanced life. Conclusion: This study shows that Meniere disease has a pervasive impact on all aspects of the patients' lives. Patients are prone to experiencing restrictions in their social functioning and activities. They also experience psychosocial problems due to the unseen nature of their symptoms. This study elucidates the experiences of Meniere patients and the need for nursing intervention to help improve their quality of life and ability to self-manage. Lastly, this study shows the need for a coordinated interdisciplinary approach to raising public awareness of the disease. | Joung, Woo Joung | Kyungpook Natl Univ, Coll Nursing, Res Inst Nursing Sci, Daegu 41944, South Korea | 56319847900 | godblessed@knu.ac.kr; | JOURNAL OF KOREAN ACADEMY OF NURSING | J KOREAN ACAD NURS | 2005-3673 | 2093-758X | 50 | 5 | SCIE;SSCI | NURSING | 2020 | 0.984 | 88.1 | 0 | 2025-06-25 | 0 | 0 | Meniere Disease; Self-Management; Qualitative Research | MENTAL-HEALTH; UNCERTAINTY; INDIVIDUALS; SYMPTOMS; ANXIETY; LIFE | Meniere Disease; Qualitative Research; Self-Management | Humans; Interviews as Topic; Meniere Disease; Qualitative Research; Quality of Life; Self-Management; human; interview; Meniere disease; psychology; qualitative research; quality of life; self care | Korean | 2020 | 2020-10 | 10.4040/jkan.20115 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | HDR image reproduction based on visual achromatic response | High-dynamic range image reproduction using tone-mapping algorithms are used for image processing to reduce the dynamic range of a real scene to be displayed on low-dynamic range devices. General tone-mapping methods are associated with the determination of local parameters for tone compression and the halo artifact connected to detail enhancements. This paper proposes a lightness-preserved tone-mapping method and a halo-artifact reduction method based on the property of visual achromatic responses. For the reproduction of the visual perception of the real scene on displays, the sensitivity parameter of the sigmoidal transfer curves is optimized for the lightness-preserved tone mapping, and anti-halo image decomposition method is applied for the halo-artifact reduction. In results, it is confirmed that the proposed method improves the performance of the tone-mapping method effectively. | Lee, Geun-Young; Kwon, Hyuk-Ju; Lee, Sung-Hak | Kyungpook Natl Univ, Sch Elect Engn, Daegu, South Korea | 37048800300; 55169908300; 7601395661 | g_y_lee@ee.knu.ac.kr;olin1223@ee.knu.ac.kr;shak2@ee.knu.ac.kr; | OPTICAL REVIEW | OPT REV | 1340-6000 | 1349-9432 | 27 | 4 | SCIE | OPTICS | 2020 | 0.89 | 88.4 | 0.09 | 2025-06-25 | 2 | 2 | Tone mapping; Lightness preservation; Halo artifact | OBJECTIVE QUALITY ASSESSMENT; TONE REPRODUCTION; ADAPTATION; MODEL | Halo artifact; Lightness preservation; Tone mapping | English | 2020 | 2020-08 | 10.1007/s10043-020-00604-w | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Adsorption of Heavy Metals Using Activated Carbon Synthesized from the Residues of Medicinal Herbs | In this study, we used activated carbon produced from the biomass recovered from the medicinal plant residue for the adsorption process. This study aimed to investigate its effectiveness to adsorb heavy metals at different activating methods and operating conditions. The carbonized residue was activated using both physical and chemical activations to produce activated carbon. The physical and chemical properties of the prepared activated carbon and iodine adsorption capacity were measured and the performance of the activated carbon as an adsorbent examined. Results showed that the physical activation exhibited optimum operating conditions at the carbonization temperature of 650 degrees C for 60 min and moisture content of 10%. Experimental results on adsorption with synthetic wastewater showed that the optimal operating conditions for the removal of Pb2+, Zn2+, and Cd2+ ions were at pH 5, temperature of 25 degrees C, adsorbent dosage of 5 g/L and contact time of 1.5 h. Adsorption index of the Freundlich adsorption isotherm was higher, and the 1/n values of Cd2+, Pb2+ and Zn2+ ions was 0.37, 0.35 and 0.22, respectively. Results showed that the activated carbon from the sample material exhibited a high regeneration capacity. | Yan, C. Z.; Kim, M. G.; Hwang, H. U.; Nzioka, A. M.; Sim, Y. J.; Kim, Y. J. | Hubei Univ Automot Technol, Shiyan, Peoples R China; Keimyung Coll Univ, Daegu, South Korea; Kyungpook Natl Univ, Daegu, South Korea; Silla Entech, Daegu, South Korea | ; Nzioka, Antony Mutua/Y-4112-2018 | 57191052533; 57191523939; 57191052477; 57191056730; 57203529016; 55699531200 | yjukim@knu.ac.kr; | THEORETICAL FOUNDATIONS OF CHEMICAL ENGINEERING | THEOR FOUND CHEM EN+ | 0040-5795 | 1608-3431 | 54 | 5 | SCIE | ENGINEERING, CHEMICAL | 2020 | 0.698 | 88.5 | 0.24 | 2025-06-25 | 7 | 7 | medicinal herb residue; chemical activation; physical activation; activated carbon; heavy metals | PLASTIC WASTES; PYROLYSIS; SURFACE | activated carbon; chemical activation; heavy metals; medicinal herb residue; physical activation | Activated carbon; Carbonization; Chemical activation; Heavy metals; Lead removal (water treatment); Carbonization temperatures; Freundlich adsorption isotherms; Optimal operating conditions; Optimum operating conditions; Physical activation; Physical and chemical properties; Regeneration capacity; Synthetic waste water; Adsorption | English | 2020 | 2020-09 | 10.1134/s0040579520050474 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Review | Low-Cost Magnetic Fe3O4/Chitosan Nanocomposites for Adsorptive Removal of Carcinogenic Diazo Dye | The eco-friendly adsorptive removal of Congo red (CR) from aqueous medium using Fe3O4/chitosan nanocomposites was investigated. The nanocomposites were synthesized by using a cost effective reductive precipitation method. The structural characterization of nanocomposties was determined by field emission scanning electron microscopy, thermal gravimetric analysis, fourier transform infrared spectroscopy, and magnetic property measurement system. Successful coating of chitosan on the iron oxide nanoparticles was confirmed by field emission scanning electron microscopy. The synthesized nanocomposites showed a maximum adsorption capacity of 47 mg/g for CR from an aqueous solution. Based on non-linear regression, the Langmuir isotherm fitted the experimental data better than the Freundlich and Tempkin models. The separation factor (R-L) calculated from the Langmuir adsorption isotherm indicated that CR adsorption on the nanocomposites was favorable. The obtained Fe3O4/chitosan nanocomposite is a cost-effective adsorbent and can be easily retrieved from an aqueous solution by a magnet after decontamination of CR. | Kadam, Avinash; Jang, Jiseon; Lim, Seong-Rin; Lee, Dae Sung | Dongguk Univ, Res Inst Biotechnol & Med Converged Sci, Biomedi Campus, Goyang Si 10326, Gyeonggi Do, South Korea; Kyungpook Natl Univ, Dept Environm Engn, Daegu 41566, South Korea; Korea Radioact Waste Agcy, R&D Inst Radioact Wastes, 174 Gajeong Ro, Daejeon 34129, South Korea; Kangwon Natl Univ, Dept Environm Engn, Chunchon 24341, Gangwon, South Korea | 56267499300; 56611137400; 14626162700; 55568524907 | srlim@kangwon.ac.kr;daesung@knu.ac.kr; | THEORETICAL FOUNDATIONS OF CHEMICAL ENGINEERING | THEOR FOUND CHEM EN+ | 0040-5795 | 1608-3431 | 54 | 4 | SCIE | ENGINEERING, CHEMICAL | 2020 | 0.698 | 88.5 | 0.14 | 2025-06-25 | 9 | 10 | Congo red; magnetic nanoparticles; chitosan; adsorption; reduction precipitation method | CONGO RED; PHOTOCATALYTIC DECOLORIZATION; CHITOSAN NANOPARTICLES; EQUILIBRIUM; PARTICLES; KINETICS; OXIDE | adsorption; chitosan; Congo red; magnetic nanoparticles; reduction precipitation method | Adsorption; Adsorption isotherms; Azo dyes; Cost effectiveness; Costs; Electron emission; Field emission; Field emission microscopes; Fourier transform infrared spectroscopy; Gravimetric analysis; Iron metallography; Magnetic nanoparticles; Magnetite; Nanocomposites; Precipitation (chemical); Scanning electron microscopy; Thermogravimetric analysis; Adsorption capacities; Field emission scanning electron microscopy; Iron oxide nanoparticle; Langmuir adsorption isotherms; Magnetic property measurement systems; Reductive precipitation; Structural characterization; Thermal gravimetric analysis; Iron oxides | English | 2020 | 2020-07 | 10.1134/s0040579520040193 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Treatment with AAV1-Rheb(S16H) provides neuroprotection in a mouse model of photothrombosis-induced ischemic stroke | We recently reported that upregulation of the constitutively active ras homolog enriched in brain [Rheb(S16H)], which induces the activation of the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway, can protect adult neurons, mediated by the induction of neurotrophic factors, such as brain-derived neurotrophic factor (BDNF), in animal models of neurodegenerative diseases. Here we show that neuronal transduction of Rheb(S16H) using adeno-associated virus serotype 1 provides neuroprotection in a mouse model of photothrombosis-induced ischemic stroke. Rheb(S16H)-expressing neurons exhibited neurotrophic effects, such as mTORC1 activation, increases in neuronal size, and BDNF production, in mouse cerebral cortex. Moreover, the upregulation of neuronal Rheb(S16H) significantly attenuated ischemic damage and behavioral impairments as compared to untreated mice, suggesting that Rheb(S16H) upregulation in cortical neurons may be a useful strategy to treat ischemic stroke. | Yoon, Dongyeong; Jeon, Min-Tae; Kim, Dong Woon; Kim, Sang Ryong | Kyungpook Natl Univ, Sch Life Sci, Daegu 41566, South Korea; Kyungpook Natl Univ, BK21 Plus KNU Creat BioRes Grp, Daegu, South Korea; Chungnam Natl Univ, Brain Res Inst, Dept Anat, Sch Med, Daejeon, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu, South Korea | 57214744587; 56018969800; 57204150578; 56486163800 | srk75@knu.ac.kr; | NEUROREPORT | NEUROREPORT | 0959-4965 | 1473-558X | 31 | 13 | SCIE | NEUROSCIENCES | 2020 | 1.837 | 88.5 | 0.37 | 2025-06-25 | 8 | 7 | brain-derived neurotrophic factor; neuroprotection; Rheb(S16H); stroke | FUNCTIONAL RECOVERY; NEUROTROPHIC FACTOR; AAV1 TRANSDUCTION; NEURONS; BRAIN; BDNF; HRHEB(S16H); PROTECTS; ROLES | brain-derived neurotrophic factor; neuroprotection; Rheb(S16H); stroke | Animals; Brain-Derived Neurotrophic Factor; Cell Enlargement; Dependovirus; Disease Models, Animal; Fluorescent Dyes; Gait Analysis; Gene Transfer Techniques; Genetic Vectors; Ischemic Stroke; Mice; Motor Cortex; Mutation; Neurons; Neuroprotection; Ras Homolog Enriched in Brain Protein; Rose Bengal; Thrombotic Stroke; Transduction, Genetic; adeno associated virus vector; brain derived neurotrophic factor; mammalian target of rapamycin complex 1; neuroprotective agent; Rheb protein; Bdnf protein, mouse; brain derived neurotrophic factor; fluorescent dye; Rheb protein; rose bengal; Adeno associated virus 1; adult; animal cell; animal experiment; animal model; animal tissue; Article; behavior disorder; brain cell; brain cortex; controlled study; enzyme activation; functional disease; in vivo study; infant; male; mouse; neuroprotection; nonhuman; photothrombotic stroke; priority journal; protein expression; serotype; signal transduction; upregulation; animal; brain ischemia; cell enlargement; Dependoparvovirus; disease model; gait; gene transfer; gene vector; genetic transduction; genetics; metabolism; motor cortex; mutation; nerve cell; neuroprotection; pathology; pathophysiology | English | 2020 | 2020-09-09 | 10.1097/wnr.0000000000001506 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Characterization of red ginseng-drug interaction by CYP3A activity increased in high dose administration in mice | Ginseng (Panax ginsengMeyer) is a popular traditional herbal medicine used worldwide. Patients often take ginseng preparations with other medicines where the ginseng dose could exceed the recommended dose during long-term administration. However, ginseng-drug interactions at high doses of ginseng are poorly understood. This study showed the possibility of herb-drug interactions between the Korean red ginseng (KRG) extract and cytochrome P450 (CYP) substrates in higher administration in mice. The CYP activities were determined in vivo after oral administration of KRG extract doses of 0.5, 1.0, and 2.0 g/kg for 2 or 4 weeks by monitoring the concentration of five CYP substrates/metabolites in the blood. The area under the curve for OH-midazolam/midazolam catalysed by CYP3A was increased significantly by the administration of 2.0 g/kg KRG extract for 2 and 4 weeks. CYP3A-catalysed midazolam 1MODIFIER LETTER PRIME-hydroxylation also increased significantly in a dose- and time-dependent manner in the S9 fraction of mouse liver which was not related to induction by transcription. Whereas CYP2D-catalysed dextromethorphanO-deethylation decreased in a dose- and time-dependent manner in vivo. In conclusion, interactions were observed between KRG extract and CYP2D and CYP3A substrates at subchronic-high doses of KRG administration in mice. | Kim, Younah; Jo, Jung Jae; Cho, Piljoung; Shrestha, Riya; Kim, Kyu Min; Ki, Sung Hwan; Song, Kyung-Sik; Liu, Kwang-Hyeon; Song, Im-Sook; Kim, Ju-Hyun; Lee, Jae-Mok; Lee, Sangkyu | Kyungpook Natl Univ, Coll Pharm, BK21 Plus KNU Multiom Based Creat Drug Res Team, Daegu, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Daegu, South Korea; Chosun Univ, Coll Pharm, Gwangju, South Korea; Yeungnam Univ, Coll Pharm, Gyongsan, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Periodontol, 2177 Dalgubeol Daero, Daegu 41940, South Korea; Kyungpook Natl Univ, Coll Pharm, Daegu 702701, South Korea | kim, kyumin/KDN-4319-2024; Shrestha, Riya/JCE-7436-2023 | 57211893872; 57191892087; 57202163312; 57193350367; 56441871900; 8346836500; 13310139000; 55768214700; 7201564500; 55720031300; 17346330000; 57209046767 | leejm@knu.ac.kr;sangkyu@knu.ac.kr; | BIOPHARMACEUTICS & DRUG DISPOSITION | BIOPHARM DRUG DISPOS | 0142-2782 | 1099-081X | 41 | 7 | SCIE | PHARMACOLOGY & PHARMACY | 2020 | 1.627 | 88.6 | 0.69 | 2025-06-25 | 8 | 8 | ginseng-drug interaction; LC-MS; MS; pharmacokinetics; red ginseng extract | ST-JOHNS-WORT; PANAX-GINSENG; CYTOCHROMES P450; GINSENOSIDES; METABOLISM; INDUCTION; MIDAZOLAM; BIOTRANSFORMATION; INHIBITION; MOUSE | ginseng–drug interaction; LC-MS/MS; pharmacokinetics; red ginseng extract | Administration, Oral; Animals; Area Under Curve; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Dextromethorphan; Dose-Response Relationship, Drug; Herb-Drug Interactions; Male; Mice; Midazolam; Panax; Plant Extracts; Time Factors; amfebutamone; caffeine; cytochrome P450 1A; cytochrome P450 2A; cytochrome P450 2B; cytochrome P450 2C; cytochrome P450 2D; cytochrome P450 3A; cytochrome P450 3A11; dextromethorphan; ginseng extract; ginsenoside Rb 1; ginsenoside Rb 2; ginsenoside Rc; ginsenoside Rd; ginsenoside Re; ginsenoside Rf; ginsenoside Rf 1; ginsenoside Rf 2; ginsenoside Rg 1; ginsenoside Rg 3; ginsenoside Rh 2; midazolam; omeprazole; protopanaxadiol; protopanaxatriol; reduced nicotinamide adenine dinucleotide phosphate; unclassified drug; CYP3A protein, mouse; cytochrome P450; cytochrome P450 3A; cytochrome P450 family 2; dextromethorphan; midazolam; plant extract; animal experiment; animal model; animal tissue; area under the curve; Article; blood analysis; catalysis; concentration process; controlled study; drug hydroxylation; drug megadose; ginseng; herb drug interaction; in vivo study; liver tissue; male; mouse; nonhuman; recommended drug dose; synergistic effect; animal; chemistry; dose response; metabolism; oral drug administration; Panax; time factor | English | 2020 | 2020-07 | 10.1002/bdd.2246 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Deoxyshikonin reversibly inhibits cytochrome P450 2B6 | Deoxyshikonin, a natural shikonin derivative, is the major component of Lithospermum erythrorhizon and exhibits various pharmacological effects such as lymphangiogenetic, antibacterial, wound healing, and anticancer effects. To investigate the herb-drug interaction potential associated with deoxyshikonin, the inhibitory effects of deoxyshikonin on eight major cytochrome P450 (CYP) enzymes were examined using cocktail substrate-incubated human liver microsomes. Deoxyshikonin strongly inhibited CYP2B6-catalyzed bupropion hydroxylation, with a K-i value of 3.5 mu M, and the inhibition was confirmed using purified human CYP2B6. The inhibition was reversible because the inhibitory effect of deoxyshikonin was not dependent on the preincubation time. The results indicated that deoxyshikonin-induced drug-drug interaction should be considered when any herb containing deoxyshikonin is used for conventional medications. | Kim, Ju-Hyun; Choi, Su Min; Shreatha, Riya; Jeong, Gil-Saeng; Jeong, Tae Cheon; Lee, Sangkyu | Yeungnam Univ, Coll Pharm, Gyongsan 38541, South Korea; Kyungpook Natl Univ, BK21 Plus KNU Multiom Based Creat Drug Res Team, Coll Pharm, Daegu 41566, South Korea; Kyungpook Natl Univ, Pharmaceut Sci Res Inst, Daegu 41566, South Korea; Keimyung Univ, Coll Pharm, Daegu 42601, South Korea | 55720031300; 57212768203; 57216866921; 57204396456; 7102759745; 57209046767 | sangkyu@knu.ac.kr; | BIOPHARMACEUTICS & DRUG DISPOSITION | BIOPHARM DRUG DISPOS | 0142-2782 | 1099-081X | 41 | 4-5 | SCIE | PHARMACOLOGY & PHARMACY | 2020 | 1.627 | 88.6 | 0.1 | 2025-06-25 | 2 | 2 | deoxyshikonin; herb-drug interaction; reversible inhibition | IN-VITRO; DRUG INTERACTIONS; HYDROXYLATION; METABOLISM; SHIKONIN; BUPROPION; P4502B6; RISK | cytochrome P450 2B6; deoxyshikonin; herb–drug interaction; reversible inhibition | Cytochrome P-450 CYP2B6 Inhibitors; Cytochrome P-450 Enzyme System; Herb-Drug Interactions; Humans; Microsomes, Liver; Naphthoquinones; amfebutamone; amodiaquine; coumarin; cytochrome P450 1A2; cytochrome P450 2A6; cytochrome P450 2B6; cytochrome P450 2C19; cytochrome P450 2C8; cytochrome P450 2C9; cytochrome P450 2D6; cytochrome P450 2E1; cytochrome P450 2J2; cytochrome P450 3A; cytochrome P450 3A4; cytochrome P450 inhibitor; deoxyshikonin; dextromethorphan; diclofenac; midazolam; omeprazole; phenacetin; shikonin derivative; thiotepa; unclassified drug; cytochrome P450; cytochrome P450 2B6 inhibitor; deoxyshikonin; naphthoquinone; Article; enzyme inhibition; herb drug interaction; human; human cell; hydroxylation; IC50; incubation time; inhibition constant; inhibition kinetics; liver microsome; multiple reaction monitoring; plasma protein binding; time-dependent inhibition; herb drug interaction; metabolism | English | 2020 | 2020 (APR-MAY) | 10.1002/bdd.2230 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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