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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | ML-Based Fast and Precise Embedded Rack Detection Software for Docking and Transport of Autonomous Mobile Robots Using 2-D LiDAR | Autonomous mobile robots (AMRs) are widely used in dynamic warehouse environments for automated material handling, which is one of the fundamental parts of building intelligent logistics systems. A target docking system to transport materials, such as racks, carts, and pallets is an important technology for AMRs that directly affects production efficiency. In this letter, we propose a fast and precise rack detection algorithm based on 2-D LiDAR data for AMRs that consume power from batteries. This novel detection method based on machine learning to quickly detect various racks in a dynamic environment consists of three modules: first classification, secondary classification, and multiple-matching-based 2-D point cloud registration. We conducted various experiments to verify the rack detection performance of the existing and proposed methods in a low-power embedded system. As a result, the relative pose accuracy is improved and the inference speed is increased by about 3 times, which shows that the proposed method has faster inference speed while reducing the relative pose error. | Hong, Sunghoon; Park, Daejin | Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea; Syscon ROBOT, Next Software Design Team, Incheon 22851, South Korea | 55726350900; 55463943600 | boltanut@knu.ac.kr; | IEEE EMBEDDED SYSTEMS LETTERS | IEEE EMBED SYST LETT | 1943-0663 | 1943-0671 | 16 | 4 | SCIE | COMPUTER SCIENCE, HARDWARE & ARCHITECTURE;COMPUTER SCIENCE, SOFTWARE ENGINEERING | 2024 | 2 | 55.1 | 0 | 2025-05-07 | 0 | 0 | Point cloud compression; Laser radar; Machine vision; Production; Machine learning; Software; Mobile robots; Pallets; Autonomous robots; Logistics; Low-power vision processing; machine learning; mobile robot; object detection | Low-power vision processing; machine learning; mobile robot; object detection | Intelligent robots; Microrobots; Robot learning; Automated material handlings; Autonomous Mobile Robot; Detection software; Logistics system; Low Power; Low-power vision processing; Machine-learning; Objects detection; Relative pose; Vision processing; Mobile robots | English | 2024 | 2024-12 | 10.1109/les.2024.3442927 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Nirmatrelvir has detrimental effects on sperm function by altering the PI3K/PDK1/AKT signaling pathway | Nirmatrelvir (NMV) is a recently developed selective inhibitor of the main protease of Sars-Cov-2 that reduces the severity of infection. Despite its widespread use and various side effects, NMV 's effect on male fertility is still unclear. This study was thus established to investigate how NMV affects male fertility. For experiments, Duroc spermatozoa were incubated with various concentrations of NMV (0, 0.1, 1, 10, 50, and 100 mu M). Then, sperm motility, motion kinematics, capacitation status, intracellular ATP level, and cell viability were evaluated. In addition, the expression levels of phospho-PKA substrates, tyrosine-phosphorylated proteins, and PI3K/PDK1/ AKT signaling pathway -related proteins were measured by western blotting. Our results showed that sperm motility, motion kinematics, proportion of capacitated spermatozoa, and intracellular ATP level were significantly decreased by NMV in a dose -dependent manner. Moreover, PKA activation was significantly suppressed by NMV, and expression levels of PI3K, phospho-PDK1, AKT, and phospho-AKT (Thr 308 and Ser 473 ) were significantly increased in a dose -dependent manner. Combining these findings, it is suggested that NMV has detrimental effects on sperm function by inducing abnormal changes in the PI3K/PDK1/AKT signaling pathway, resulting in PKA deactivation. Therefore, there is a need to pay particular attention to its male reproductive toxicity when NMV is administered. | Jung, Eun-Ju; Jo, Jae-Hwan; Uwamahoro, Claudine; Jang, Seung-Ik; Hwang, Ju-Mi; Lee, Woo-Jin; Bae, Jeong-Won; Ryu, Do-Yeal; Kwon, Woo-Sung | Kyungpook Natl Univ, Dept Anim Sci & Biotechnol, Sangju 37224, Gyeongsangbug, South Korea; Kyungpook Natl Univ, Dept Anim Biotechnol, Sangju 37224, Gyeongsangbuk D, South Korea; NCI, Ctr Canc Res, Genet Branch, NIH, Bethesda, MD 20892 USA; Kyungpook Natl Univ, Res Inst Innovat Anim Sci, Sangju 37224, Gyeongsangbug D, South Korea; Kyungpook Natl Univ, Res Inst Innovat Anim Sci, Dept Anim Sci & Biotechnol, Dept Anim Biotechnol, Sangju 37224, Gyeongsangbugdo, South Korea | Kwon, Woo-Sung/J-6731-2019; Bae, Jeong-Won/AAH-4932-2021 | 57377289200; 58346379700; 58844996200; 58346379800; 57217871526; 55682653854; 57211231093; 56915346200; 54383715800 | doyeal.yu@nih.gov;wskwon@knu.ac.kr; | TOXICOLOGY IN VITRO | TOXICOL IN VITRO | 0887-2333 | 1879-3177 | 99 | SCIE | TOXICOLOGY | 2024 | 2.7 | 55.2 | 0.51 | 2025-05-07 | 1 | 1 | Nirmatrelvir; Sperm function; PI3K/PDK1/AKT signaling pathway; Capacitation | PHOSPHOINOSITIDE 3-KINASE; PROTEIN-KINASE; MOTILITY; AKT; PHOSPHORYLATION; CAPACITATION; APOPTOSIS; CAMP; PROLIFERATION; SPERMATOZOA | Capacitation; Nirmatrelvir; PI3K/PDK1/AKT signaling pathway; Sperm function | Adenosine Triphosphate; Animals; Cell Survival; Male; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Signal Transduction; Sperm Capacitation; Sperm Motility; Spermatozoa; Swine; adenosine triphosphate; cyclic AMP dependent protein kinase; nirmatrelvir; phosphatidylinositol 3 kinase; phosphoinositide dependent protein kinase 1; phosphoprotein; protein kinase B; serine; tyrosine; adenosine triphosphate; phosphatidylinositol 3 kinase; protein kinase B; pyruvate dehydrogenase kinase; animal cell; Article; cell level; cell viability; controlled study; dose response; drug concentration; Duroc pig; enzyme activation; enzyme inactivation; enzyme repression; enzyme substrate; kinematics; male; male fertility; nonhuman; Pi3K/Akt signaling; protein expression level; protein phosphorylation; reproductive toxicity; sperm capacitation; sperm function; spermatozoon; spermatozoon motility; Western blotting; animal; cell survival; drug effect; metabolism; pig; signal transduction; spermatozoon; spermatozoon motility | English | 2024 | 2024-08 | 10.1016/j.tiv.2024.105848 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Identification of EIMD Level Differences Between Long- and Short Head of Biceps Brachii Using Echo Intensity and GLCM Texture Features | Purpose: This study aimed to compare the time-course changes of exercise-induced muscle damage (EIMD) levels in the long head of biceps brachii (LHB) and short head of the biceps brachii (SHB) using echo intensity (EI) and to determine the efficiency of the gray level co-occurrence matrix (GLCM) texture parameters. Methods: The participants performed 30 maximal eccentric contractions of the elbow flexor. Along with muscle damage indicators, including circumference, range of motion, muscle soreness, and maximal voluntary isometric contraction (MVIC), the EI and GLCM texture features of the LHB and SHB was also assessed using B-mode ultrasonography. All measurements were assessed pre- and immediately post-exercise and after 24, 48, 72, and 96 h. Results: The muscle damage indicators indicated significant changes after the eccentric contractions (p 0.05). In contrast, for the GLCM texture parameters, there were significant changes in the SHB (p < 0.01 for homogeneity, energy, and entropy). Conclusion: Thus, this study demonstrated that EIMD severity is different between LHB and SHB even within the same muscle. In the GLCM features, the time course of SHB after eccentric contraction revealed different patterns compared with those of LHB. Therefore, even if there are no changes in EI within a target muscle following muscle contractions, new information on muscle quality can be obtained through GLCM analysis. | Jo, Hyeon-Deok; Kim, Maeng-Kyu | Kyungpook Natl Univ, Daegu, South Korea; Kyungpook Natl Univ, Dept Phys Educ, Sports Med Lab, 80 Daehak Ro, Daegu 41566, South Korea | 57226105432; 26021932400 | kimmk@knu.ac.kr; | RESEARCH QUARTERLY FOR EXERCISE AND SPORT | RES Q EXERCISE SPORT | 0270-1367 | 2168-3824 | 95 | 2 | SSCI;SCIE | HOSPITALITY, LEISURE, SPORT & TOURISM;PSYCHOLOGY, APPLIED;PSYCHOLOGY;SPORT SCIENCES | 2024 | 1.6 | 55.3 | 0.83 | 2025-04-16 | 3 | 2 | Echo intensity; exercise-induced muscle damage; gray-level co-occurrence matrix; texture analysis; ultrasonography | INDUCED MUSCLE DAMAGE; HUMAN SKELETAL-MUSCLE; ECCENTRIC EXERCISE; ELBOW FLEXORS; ULTRASOUND IMAGE; MAGNITUDE; RESPONSES | Echo intensity; exercise-induced muscle damage; gray-level co-occurrence matrix; texture analysis; ultrasonography | Adult; Arm; Elbow; Exercise; Female; Humans; Isometric Contraction; Male; Muscle, Skeletal; Myalgia; Range of Motion, Articular; Ultrasonography; Young Adult; adult; arm; diagnostic imaging; echography; elbow; etiology; exercise; female; human; male; muscle isometric contraction; myalgia; pathophysiology; physiology; range of motion; skeletal muscle; young adult | English | 2024 | 2024-04-02 | 10.1080/02701367.2023.2250832 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Therapeutic effects of hederacolchiside A1 on particulate matter-induced pulmonary injury | Particulate matter (PM) comprises a hazardous mixture of inorganic and organic particles that carry health risks. Inhaling fine PM particles with a diameter of <= 2.5 mu m (PM2.5) can promote significant lung damage. Hederacolchiside A1 (HA1) exhibits notable in vivo antitumor effects against various solid tumors. However, our understanding of its therapeutic potential for individuals with PM2.5-induced lung injuries remains limited. Here, we explored the protective properties of HA1 against lung damage caused by PM2.5 exposure. HA1 was administered to the mice 30 min after intratracheal tail vein injection of PM2.5. Various parameters, such as changes in lung tissue wet/dry (W/D) weight ratio, total protein/total cell ratio, lymphocyte counts, inflammatory cytokine levels in bronchoalveolar lavage fluid (BALF), vascular permeability, and histology, were assessed in mice exposed to PM2.5. Our data showed that HA1 mitigated lung damage, reduced the W/D weight ratio, and suppressed hyperpermeability caused by PM2.5 exposure. Moreover, HA1 effectively decreased plasma levels of inflammatory cytokines in those exposed to PM2.5, including tumor necrosis factor-alpha, interleukin-113, and nitric oxide, while also lowering the total protein concentration in BALF and successfully alleviating PM2.5induced lymphocytosis. Furthermore, HA1 significantly decreased the expression levels of toll-like receptor 4 (TLR4), myeloid differentiation primary response (MyD) 88, and autophagy-related proteins LC3 II and Beclin 1 but increased the protein phosphorylation of the mammalian target of rapamycin (mTOR). The antiinflammatory characteristics of HA1 highlights its potential as a promising therapeutic agent for mitigating PM2.5-induced lung injuries by modulating the TLR4-MyD88 and mTOR-autophagy pathways. | Cho, Sanghee; Choi, Hui Ji; Song, Gyu Yong; Bae, Jong-Sup | Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, Daegu 41566, South Korea; Chungnam Natl Univ, Coll Pharm, 99 Daehak Ro, Daejeon 34134, South Korea; Kyungpook Natl Univ, Coll Pharm, 80 Daehak ro, Daegu 41566, South Korea | 58784915200; 57220585937; 58856541700; 16021543200 | gysong@cnu.ac.kr;baejs@knu.ac.kr; | TOXICON | TOXICON | 0041-0101 | 1879-3150 | 241 | SCIE | PHARMACOLOGY & PHARMACY;TOXICOLOGY | 2024 | 2.4 | 55.3 | 0.51 | 2025-05-07 | 1 | 1 | Hederacolchiside A1; Particulate matter; Lung injury; TLR4-mTOR-autophagy pathway | ACUTE LUNG INJURY; NF-KAPPA-B; INFLAMMATION; ACTIVATION; PM2.5; MTOR | Hederacolchiside A1; Lung injury; Particulate matter; TLR4–mTOR–autophagy pathway | Animals; Cytokines; Lung; Lung Injury; Mammals; Mice; Particulate Matter; Toll-Like Receptor 4; TOR Serine-Threonine Kinases; autophagy related protein; beclin 1; cytokine; dexamethasone; hederacolchiside A1; interleukin 10; interleukin 1beta; mammalian target of rapamycin; myeloid differentiation factor 88; myeloperoxidase; nitric oxide; toll like receptor 4; triterpenoid; tumor necrosis factor; unclassified drug; cytokine; target of rapamycin kinase; toll like receptor 4; animal cell; animal experiment; animal model; animal tissue; antiinflammatory activity; Article; blood vessel permeability; cell count; cell lysate; controlled study; cytokine production; enzyme linked immunosorbent assay; histopathology; lung injury; lung lavage; lung parenchyma; lymphocyte count; lymphocytosis; male; mouse; MVEC cell line; nonhuman; particulate matter 2.5; protein phosphorylation; respiratory tract parameters; signal transduction; staining; Western blotting; animal; lung; mammal; metabolism; particulate matter | English | 2024 | 2024-04 | 10.1016/j.toxicon.2024.107650 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Real-world safety and effectiveness of lenvatinib in unresectable hepatocellular carcinoma in Korea: post-marketing study | Aim: This post-marketing surveillance study evaluated the safety and effectiveness of lenvatinib as first-line treatment for unresectable hepatocellular carcinoma in Korea. Materials & methods: Adverse drug reactions (ADRs) and other safety and effectiveness end points were assessed in patients who initiated lenvatinib according to the approved label in republic of Korea. Results: Among 658 lenvatinib-treated patients, ADRs were reported in 57.8%; ADRs grade >= 3 in 13.5%. The most common grade >= 3 ADRs were asthenia (1.2%) and hepatic encephalopathy (1.2%). Physician-reported tumor responses (n = 511) were complete (1.0%) or partial (12.9%) response and stable (45.2%) or progressive disease (40.9%); objective response rates were higher with longer lenvatinib treatment duration (p < 0.001). Conclusion: Lenvatinib was generally well tolerated and effective in real-world clinical practice in Korea. | Kang, Wonseok; Kim, Yoon Jun; Kim, Seung Up; Seo, Yeon Seok; Kim, Jin-Wook; Kim, Ji Hoon; Park, Soo Young; Baek, Yang-Hyun; Kim, Kang Mo; Lee, Hae Lim; Yoon, Ki Tae; Kim, Hyeyeong; Cheong, Jae Youn; Hwang, Jae Seok; Kim, Ju Hyun; Kim, Kwang Min; Sung, Pil Soo; Kim, Jieun; Kim, Do Young | Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Med, Seoul, South Korea; Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Seoul Natl Univ, Liver Res Inst, Coll Med, Seoul, South Korea; Yonsei Univ, Yonsei Liver Ctr, Coll Med, Dept Internal Med, Seoul, South Korea; Korea Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Seoul Natl Univ, Bundang Hosp, Coll Med, Dept Internal Med, Seongnam, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Dong A Univ, Coll Med, Dept Internal Med, Busan, South Korea; Univ Ulsan, Asan Liver Ctr, Asan Med Ctr, Coll Med,Dept Gastroenterol, Seoul, South Korea; Catholic Univ Korea, Bucheon St Marys Hosp, Coll Med, Dept Internal Med, Bucheon, South Korea; Pusan Natl Univ, Yangsan Hosp, Coll Med, Dept Internal Med, Yangsan, South Korea; Ulsan Univ Hosp, Dept Med Oncol, Ulsan, South Korea; Ajou Univ, Sch Med, Dept Gastroenterol, Suwon, South Korea; Keimyung Univ, Sch Med, Dongsan Med Ctr, Dept Internal Med, Daegu, South Korea; Gachon Univ Med & Sci, Dept Internal Med, Incheon, South Korea; Sungkyunkwan Univ, Samsung Changwon Hosp, Sch Med, Dept Med, Changwon Si, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Div Hepatol,Dept Internal Med, Seoul, South Korea; Eisai Korea Inc, Dept Med, Seoul, South Korea | Kim, Yoon/J-2746-2012; Kim, Sun/L-4239-2013; Sung, Pil/K-2072-2019; Kim, Dong/F-4608-2014; Kim, Jin-Wook/J-5442-2012 | 19640141000; 25947520600; 54933821200; 35234912400; 54401306800; 57328819200; 57191674344; 15844799800; 8556832000; 56386323100; 14820137300; 57223158708; 7004933299; 57205851488; 57216524819; 57207404351; 57206341074; 57941209000; 56119929100 | dyk1025@yuhs.ac; | FUTURE ONCOLOGY | FUTURE ONCOL | 1479-6694 | 1744-8301 | 20 | 37 | SCIE | ONCOLOGY | 2024 | 2.6 | 55.4 | 0 | 2025-05-07 | 0 | 0 | effectiveness; hepatocellular carcinoma; Korean population; lenvatinib; real-world practice; REFLECT trial; safety | effectiveness; hepatocellular carcinoma; Korean population; lenvatinib; real-world practice; REFLECT trial; safety | Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Hepatocellular; Female; Humans; Liver Neoplasms; Male; Middle Aged; Phenylurea Compounds; Product Surveillance, Postmarketing; Protein Kinase Inhibitors; Quinolines; Republic of Korea; Treatment Outcome; lenvatinib; antineoplastic agent; carbanilamide derivative; lenvatinib; protein kinase inhibitor; quinoline derivative; abdominal pain; adult; aged; Article; ascites; asthenia; clinical practice; computer assisted tomography; decreased appetite; diarrhea; disease duration; drug efficacy; drug safety; drug surveillance program; endoscopy; female; first-line treatment; follow up; hand foot syndrome; hepatic encephalopathy; hospitalization; human; hypertension; internal consistency; liver cell carcinoma; major clinical study; male; marketing; Medical Dictionary for Regulatory Activities; multicenter study; muscle weakness; nuclear magnetic resonance imaging; observational study; postmarketing surveillance; prospective study; proteinuria; treatment response; vomiting; drug therapy; liver cell carcinoma; liver tumor; middle aged; pathology; South Korea; treatment outcome; very elderly | English | 2024 | 2024-11-25 | 10.1080/14796694.2024.2397328 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Risk Factors Affecting Clinical Outcomes of Low-risk Early-stage Human Papillomavirus-Associated Endocervical Adenocarcinoma Treated by Surgery Alone: Application of Silva Pattern | This study aimed to report the clinical outcomes and risk factors for survival of patients with low-risk early-stage human papillomavirus-associated (HPVA) endocervical adenocarcinoma (EAC) treated with surgery alone. This retrospective study obtained the clinicopathological data of patients with early-stage HPVA EAC who underwent surgery between 2012 and 2018. The Silva pattern of invasion was determined by reviewing pathology slides. Locoregional recurrence-free survival (RFS), RFS, and overall survival were calculated, and the risk factors for survival were analyzed. One hundred seventeen patients with a median follow-up of 5.2 years (0.5-9.7 yr) were included. The most common histologic type was usual (94/117, 80.3%). The Silva pattern was A in 79 patients (67.5%), B in 30 (25.6%), and C in 8 (6.8%). The 5-year locoregional RFS, RFS, and overall survival rates were 92.4%, 87.8%, and 97.2%, respectively. The presence of intermediate-risk factors and Silva pattern C were significantly associated with worse survival. Based on these findings, patients were categorized into 2 groups: Group 1 (Silva pattern A or Silva pattern B without intermediate-risk factors) and Group 2 (Silva pattern B with intermediate-risk factors or Silva pattern C). Group 2 showed significantly worse outcomes than Group 1, including the 5-year locoregional RFS (98.6% vs 68.0%), RFS (96.4% vs 54.6%), and overall survival (100.0% vs 86.5%). In conclusion, surgery alone for early-stage HPVA EAC resulted in favorable outcomes. Consideration of the Silva pattern, in addition to well-known risk factors, could help in precise risk group stratification of low-risk, early-stage HPVA EAC. | Bae, Bong Kyung; Bae, Hyunsik; Cho, Won Kyung; Kim, Byoung-Gie; Choi, Chel Hun; Kim, Tae-Joong; Lee, Yoo-Young; Lee, Jeong-Won; Kim, Hyun-Soo; Park, Won | Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Radiat Oncol, Seoul, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Pathol & Translat Genom, 81 Irwon ro, Seoul 06351, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Obstet & Gynecol, Seoul, South Korea; Kyungpook Natl Univ, Dept Radiat Oncol, Chilgok Hosp, Daegu, South Korea | LEE, Jeong/AFN-1051-2022; LEE, HUI JEONG/KUD-2723-2024 | 57191481610; 57188965200; 57201979532; 17233649700; 11939248200; 29767612300; 29767612900; 57203144610; 57191717678; 55663053400 | bae8808@gmail.com;hyunsik.bae@samsung.com;wklove.cho@samsung.com;bgkim@skku.edu;huna0@naver.com;tj28.kim@samsung.com;yooyoung.lee@samsung.com;garden.lee7@gmail.com;hyun-soo_kim@naver.com;wonp68@skku.edu;wonro.park@samsung.com; | INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY | INT J GYNECOL PATHOL | 0277-1691 | 1538-7151 | 43 | 5 | SCIE | OBSTETRICS & GYNECOLOGY;PATHOLOGY | 2024 | 1.7 | 55.4 | 0 | 2025-05-07 | 0 | 0 | Cervix uteri; Endocervix; Adenocarcinoma; Neoplasm invasiveness; Risk factors; Recurrence | CERVICAL ADENOCARCINOMA; CLASSIFICATION-SYSTEM; INTERNATIONAL SOCIETY; CANCER; RECOMMENDATIONS; RECURRENCE; FEATURES | Adenocarcinoma; Cervix uteri; Endocervix; Neoplasm invasiveness; Recurrence; Risk factors | Adenocarcinoma; Adult; Aged; Disease-Free Survival; Female; Human Papillomavirus Viruses; Humans; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Papillomaviridae; Papillomavirus Infections; Retrospective Studies; Risk Factors; Uterine Cervical Neoplasms; adult; Article; bilateral salpingooophorectomy; cancer staging; cancer surgery; cancer survival; cervicotomy; clinical assessment; clinical outcome; controlled study; disease association; distant metastasis; early cancer; female; follow up; histopathology; human; human tissue; intermediate risk patient; local recurrence free survival; low risk patient; lymph node dissection; major clinical study; male; outcome assessment; overall survival; papillomavirus infection; para-aortic lymphadenectomy; patient; pelvis lymph node; population; radical hysterectomy; recurrent disease; retrospective study; risk factor; total hysterectomy; tumor invasion; uterine cervix adenocarcinoma; Wart virus; adenocarcinoma; aged; cancer staging; complication; disease free survival; isolation and purification; middle aged; mortality; Papillomaviridae; pathology; risk factor; surgery; tumor recurrence; uterine cervix tumor; virology; Wart virus | English | 2024 | 2024-09 | 10.1097/pgp.0000000000001007 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Effects of Thawing Conditions on the Physicochemical and Microbiological Quality of Thawed Beef | This study aimed to determine the effects of thawing methods such as thawing in a refrigerator, at room temperature, in cold water, and using a microwave oven on the pH, color value, 2-thiobarbituric acid (TBA) value, water-holding capacity, thawing loss, textural attributes, microbial status, and morphology of frozen beef samples. The redness (a*) value of beef samples thawed in cold water for prolonged time and those thawed at room temperature for prolonged time significantly increased compared with that of samples thawed using other methods. The TBA value and thawing loss of beef samples thawed in a refrigerator were significantly lower than those of samples thawed using other methods. Regardless of the thawing method used, beef samples thawed for prolonged time showed significantly high TBA values. With regard to texture, beef samples thawed using a microwave oven showed the maximum hardness compared with those thawed using other methods. The total aerobic bacterial count in fresh beef samples was 1.98 log colony-forming unit (CFU)/g, whereas that in samples thawed at room temperature was 2.49 log CFU/g. Beef samples thawed at room temperature for prolonged time and those thawed using a microwave oven showed irregular structure. These data demonstrated that the thawing condition affects the physicochemical and microbiological qualities of beef, with thawing in a refrigerator resulting in superior beef quality than thawing at room temperature or using a microwave oven. | Park, Mi Hye; Kim, Meera | Kyungpook Natl Univ, Dept Food Sci & Nutr, Daegu 41566, South Korea | 57200230726; 7406089808 | meerak@knu.ac.kr; | PREVENTIVE NUTRITION AND FOOD SCIENCE | PREV NUTR FOOD SCI | 2287-1098 | 2287-8602 | 29 | 1 | ESCI | FOOD SCIENCE & TECHNOLOGY;NUTRITION & DIETETICS | 2024 | 2.5 | 55.5 | 2.3 | 2025-04-16 | 6 | 6 | beef quality; color value; microbial status; TBA value; thawing loss | ESCHERICHIA-COLI O157-H7; FROZEN FOODS; MEAT; STORAGE; TEMPERATURE; SURVIVAL; MUSCLE; PORK | beef quality; color value; microbial status; TBA value; thawing loss | English | 2024 | 2024-03 | 10.3746/pnf.2024.29.1.80 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Exploring the Therapeutic Potentials and Molecular Mechanisms of Coscinium fenestratum Alkaloids in Ulcerative Colitis: An Integrative Network Pharmacology and Molecular Docking Approach | Coscinium fenestratum, a medicinal plant traditionally used in Southeast Asia, exerts protective effects against various inflammatory diseases, primarily due to its rich alkaloid content. Despite substantial evidence supporting its antiinflammatory properties, the biological activities of C. fenestratum are unclear. This study aimed to elucidate anticolitis mechanisms of C. fenestratum alkaloids (CFAs) using an integrative approach of network pharmacology and molecular docking analyses. Key active alkaloids and core target genes were identified through pharmacological and protein-protein interaction networks. The core targets were enriched in the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathways to determine the functional properties of active CFA. Finally, the binding affinity of the key compounds with the core targets was determined using molecular docking. The results showed that 11 active CFAs interactively interfered with 10 hub genes related to ulcerative colitis, including prostaglandin-endoperoxide synthase 2 (PTGS2), selectin E (SELE), kinase insert domain receptor (KDR), fms-related receptor tyrosine kinase 1 (FLT1), intracellular adhesion molecule 1 (ICAM1), and MMP9, which were functionally involved in the immunological response, tumor necrosis factor signaling pathway, and interleukin-17 signaling pathway. The molecular docking results indicated that CFA compounds had a strong binding affinity for the hub genes. The findings reveal, for the first time, a therapeutic role of CFA in alleviating ulcerative colitis through its predicted interactions with relevant biological targets. | Park, Ji-Won; Rarison, Razanamanana H. G.; Truong, Van-Long; Jeong, Woo-Sik | Kyungpook Natl Univ, Coll Agr & Life Sci, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Kyungpook Natl Univ, Food & Bioind Res Inst, Biotechnol Coll Agr & Life Sci, Sch Food Sci, Daegu 41566, South Korea | Park, Ji Won/JCD-9105-2023; Jeong, Woo-Sik/AAN-6885-2020 | 57447022500; 57930282700; 55925363400; 10440750200 | wsjeong@knu.ac.kr; | PREVENTIVE NUTRITION AND FOOD SCIENCE | PREV NUTR FOOD SCI | 2287-1098 | 2287-8602 | 29 | 4 | ESCI | FOOD SCIENCE & TECHNOLOGY;NUTRITION & DIETETICS | 2024 | 2.5 | 55.5 | 0 | 2025-05-07 | 0 | 1 | alkaloids; colitis; molecular docking simulation; network pharmacology | COLONIC DAMAGE; EXPRESSION; EXTRACT; CXCR4; TNF | alkaloids; colitis; molecular docking simulation; network pharmacology | English | 2024 | 2024-12 | 10.3746/pnf.2024.29.4.441 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Fermentation Characteristics of Unripe Citrus unshiu Vinegar Production Using Acetic Acid Bacteria Isolated from Traditional Fermented Vinegars | Here, we aimed to isolate an acetic acid bacterium that is suitable for the production of unripe Citrus unshiu vinegar from traditional fermented vinegars. We compared the halo sizes of isolates to select a strain with superior acetic acid production capabilities and selected Komagataeibacter kakiaceti P6 (P6) as the final strain. Using Acetobacter pasteurianus CY (CY) and A. pasteurianus KACC 17058 (KACC 17058) as controls, we analyzed the total phenolic compounds, total flavonoid content, antioxidant activities, and organic acids of the selected strain to verify its suitability for acetic acid fermentation. On the 30th day of the fermentation period, P6 showed a total acidity of 4.86%, which was higher than that of control groups (CY, 4.16%; KACC 17058, 4.01%). The total phenolic compounds, total flavonoid content, 1,1-diphenyl-2picrylhydrazyl scavenging activity, and ferric ion reducing antioxidant power values significantly increased during fermentation with P6 compared with the initial C. unshiu wine, and no significant differences were observed from the vinegars produced by CY and KACC 17058. Moreover, organic acid analysis revealed that the unripe C. unshiu vinegar produced with P6 had an acetic acid content of 26.15 mg/mL, which was significantly higher than those produced with CY and KACC 17058, indicating that the P6 strain effectively produces acetic acid without adversely affecting other quality aspects during fermentation. In conclusion, the novel P6 strain is expected to be used as a starter for fermenting unripe C. unshiu vinegar, and its excellent acetic acid production capabilities suggest potential applications for other vinegars. | Won, Sang-Hun; Kim, Yeong-Jun; Choi, Kyu-Taek; Choi, Jun-Su; Park, Heui-Dong; Lee, Sae-Byuk | Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Kyungpook Natl Univ, Inst Fermentat Biotechnol, Daegu 41566, South Korea | Choi, Jun-Su/MVY-2121-2025 | 59207940500; 58939509300; 57204645058; 57195937178; 7601568590; 57188742752 | lsbyuck@knu.ac.kr; | PREVENTIVE NUTRITION AND FOOD SCIENCE | PREV NUTR FOOD SCI | 2287-1098 | 2287-8602 | 29 | 2 | ESCI | FOOD SCIENCE & TECHNOLOGY;NUTRITION & DIETETICS | 2024 | 2.5 | 55.5 | 0.52 | 2025-05-07 | 0 | 1 | acetic acid bacteria; Citrus unshiu; fermentation; Komagataeibacter kakiaceti; vinegar | acetic acid bacteria; Citrus unshiu; fermentation; Komagataeibacter kakiaceti; vinegar | English | 2024 | 2024-06 | 10.3746/pnf.2024.29.2.220 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Inhibitory Effect of Phenolic Compounds on Vascular Endothelial Growth Factor-Induced Retinal Endothelial Permeability and Angiogenesis | Age-related macular degeneration (AMD), often triggered by endothelial barrier disruption through vascular endothelial growth factor (VEGF), is a leading cause of blindness. This study investigated the inhibitory effects of phenolic compounds on VEGF-induced endothelial cell proliferation, migration, angiogenesis, and permeability using human retinal microvascular endothelial cells (hRECs). Thirty-seven polyphenolic compounds were selected from various databases based on their antioxidant properties, abundance in food, and solubility. These compounds significantly reduced migration, tube formation, and endothelial permeability in VEGF-stimulated hRECs. Notably, formononetin, eriodictyol, biochanin A, and p-coumaric acid were more effective in suppressing VEGF-induced angiogenesis and endothelial permeability than lutein. Molecular docking simulations revealed that formononetin, eriodictyol, and biochanin A had relatively lower binding energies with VEGF receptor 2 (VEGFR2) than lutein and sorafenib. These findings highlight the potential of phenolic compounds to be used as VEGFR2 inhibitors and an alternative strategy for preventing AMD. | Kim, Dong Yoon; Hong, Seong-Min; Cho, Jeong-Seok; Lee, Sae-Byuk; Cho, Hyun-Dong | Sunchon Natl Univ, Dept Food & Nutr, Jeonnam 57922, South Korea; Gachon Univ, Coll Pharm, Incheon 21936, South Korea; Korea Food Res Inst, Food Safety & Distribut Res Grp, Jeonbuk 55365, South Korea; Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Kyungpook Natl Univ, Inst Fermentat Biotechnol, Daegu 41566, South Korea | 59363102000; 57194647985; 56310090800; 57188742752; 55383853000 | hdcho@scnu.ac.kr; | PREVENTIVE NUTRITION AND FOOD SCIENCE | PREV NUTR FOOD SCI | 2287-1098 | 2287-8602 | 29 | 3 | ESCI | FOOD SCIENCE & TECHNOLOGY;NUTRITION & DIETETICS | 2024 | 2.5 | 55.5 | 0 | 2025-05-07 | 1 | 1 | angiogenesis; macular degeneration; polyphenols; vascular permeability | VEGF | angiogenesis; macular degeneration; polyphenols; vascular permeability | English | 2024 | 2024-09 | 10.3746/pnf.2024.29.3.321 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Protective Effects of Peanut Sprouts from a Smart Farming System on the Barrier Function of Human Epithelial Cells | Inflammatory bowel disease, including Crohn's disease and ulcerative colitis, poses an emerging threat as it can lead to colorectal cancer, thrombosis, and other chronic conditions. The present study demonstrated the protective effects of peanut sprout extracts (PSEs) prepared from day 2 to day 7 of germination against lipopolysaccharide (LPS)-induced epithelial barrier breakdown. Although the peanut sprout length increased in a time-dependent manner from day 1 to day 7, the extraction yields remained relatively consistent from day 2 to day 7. With regard to antioxidant activities, the PSE from day 6 of germination exhibited the highest oxidative radical scavenging activity and total phenolic content. Similarly, it showed remarkable anti-permeability effects in LPS-stimulated Caco-2 cells and suppressed the degradation and dissociation of junctional markers (e.g., ZO-1 and E-cadherin) at cell-cell junctions. Collectively, these data demonstrate that PSE from day 6 of germination can be used as a functional food resource to reduce inflammatory barrier dysfunction. | Kim, Dong Yoon; Kim, Soo-Sung; Choi, Eun-Jin; Kim, Hoon; Kim, Dong Hyeon; Hong, Seong-Min; Lee, Sae-Byuk; Cho, Hyun-Dong | Sunchon Natl Univ, Dept Food & Nutr, Sunchon 57922, South Korea; Sunchon Natl Univ, Glocal Univ Project Team, Sunchon 57922, South Korea; NANUMBIO Co Ltd, Sunchon 57922, South Korea; Gachon Univ, Coll Pharm, Incheon 21936, South Korea; Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Kyungpook Natl Univ, Inst Fermentat Biotechnol, Daegu 41566, South Korea | 59363102000; 59508291000; 59507958600; 59508204500; 57203687792; 57194647985; 57188742752; 55383853000 | hdcho@scnu.ac.kr; | PREVENTIVE NUTRITION AND FOOD SCIENCE | PREV NUTR FOOD SCI | 2287-1098 | 2287-8602 | 29 | 4 | ESCI | FOOD SCIENCE & TECHNOLOGY;NUTRITION & DIETETICS | 2024 | 2.5 | 55.5 | 0 | 2025-05-07 | 0 | 0 | antioxidants; Arachis; inflammatory bowel diseases; intestinal barrier function | INFLAMMATORY-BOWEL-DISEASE; ANTIOXIDANT ACTIVITY; RESVERATROL; PREVALENCE; TIME | antioxidants; Arachis; inflammatory bowel diseases; intestinal barrier function | English | 2024 | 2024-12 | 10.3746/pnf.2024.29.4.474 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Validation of the High-Performance Liquid Chromatography Method for Determining Quercitrin in Capsicum annuum L. Cultivar Dangjo | Capsicum annuum L. cultivar Dangjo (DJ), developed as a novel crop, possesses potential health benefits, such as reducing blood glucose levels. DJ contains flavonoid glycosides, bioactive compounds that have been found in various plants and have promising pharmacological effects. A representative flavonol glycoside is quercitrin, a standard compound. Notwithstanding, its adoption by the food industry, it is necessary to standardize the quantification of quercitrin in DJ. Thus, an analytical method needs to be developed and validated to quantify quercitrin accurately. In this study, we established a high-performance liquid chromatography (HPLC) method for quantifying quercitrin in DJ extracts (DJEs); then, we validated the method, to ensure its accuracy and reliability. Our results demonstrated that the HPLC method effectively detecteds quercitrin in DJE samples, consistently reporting retention times and peak spectra similar to those in the standard solutions. The linearity assessment revealed a linear response within the concentration range of 2.5 to 15.0 mu g/mL, which was supported by strong correlation coefficients (R2>0.9997). Accuracy assessment via recovery studies produced satisfactory results (89.02%-99.30%), with a relative standard deviation (RSD) within acceptable limits (0.50%-5.95%). Precision analysis confirmed the repeatability and reproducibility of the method, with RSD values within the Association of Official Agricultural Chemists (AOAC) standard criteria (<= 8%). Overall, our study provides a validated HPLC method for quercitrin quantification in DJEs, facilitating its standardization and ensuring the accuracy of the analysis. This method is potentially valuable for quality control and further research on the health-promoting properties of DJ. | Fauziah, Ardina Nur; Kim, Min Jeong; So, Bo Ram; Son, Joe Eun; Jung, Sung Keun | Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Kyungpook Natl Univ, Res Inst Tailored Food Technol, Daegu 41566, South Korea | ; Jung, SUNG KEUN/AGR-2623-2022 | 59505841700; 57215818497; 57218122440; 35362802300; 35310491400 | skjung04@knu.ac.kr; | PREVENTIVE NUTRITION AND FOOD SCIENCE | PREV NUTR FOOD SCI | 2287-1098 | 2287-8602 | 29 | 4 | ESCI | FOOD SCIENCE & TECHNOLOGY;NUTRITION & DIETETICS | 2024 | 2.5 | 55.5 | 0 | 2025-05-07 | 0 | 0 | high-performance liquid chromatography; pepper; quencitrin; standardization; validation | HPLC; REPRODUCIBILITY; REPEATABILITY | high-performance liquid chromatography; pepper; quencitrin; standardization; validation | English | 2024 | 2024-12 | 10.3746/pnf.2024.29.4.504 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Article | Comparison of blood profiles between housed and grazing Korean indigenous cattle (Hanwoo) | The objective of this study was to compare the hematology profiles of Korean indigenous cattle (Hanwoo) raised in a barn (housed) or on pasture (grazing). Our findings showed significant differences in the red blood cell (RBC) profiles of these 2 groups. When compared to cattle raised in a barn, a significant decrease in hematocrit (P = 0.000), hemoglobin (P = 0.000), and red blood cells (RBCs) (P = 0.000) and a significant increase in mean cell volume (P = 0.015) and reticulocytes (P = 0.000) were observed in grazing cattle, which indicate regenerative anemia. Furthermore, indirect bilirubin was significantly higher in grazing cattle, which indicates intravascular hemolysis and neutropenia (P = 0.000), and monocytosis (P = 0.000) was also identified. To the best of our knowledge, this is the first study that demonstrates changes in reticulocyte count and indirect bilirubin levels secondary to regenerative intravascular hemolysis in grazing cattle. | Kim, Youngjun; Ku, Ji-Yeong; Park, Kwang-Man; Baek, Jonghun; Choi, Kyoung-Seong; Park, Jinho | Jeonbuk Univ, Dept Vet Internal Med, Coll Vet Med, Iksan 54596, South Korea; Natl Agr Cooperat Federat, Dept Anim Hosp, Hanwoo Korean Indigenous Cattle Genet Improvement, Seosan 31948, South Korea; Kyungpook Natl Univ, Dept Anim Sci & Biotechnol, Coll Ecol & Environm Sci, Sangju 37224, South Korea | kschoi3@knu.ac.kr;jpark@jbnu.ac.kr; | CANADIAN JOURNAL OF VETERINARY RESEARCH-REVUE CANADIENNE DE RECHERCHE VETERINAIRE | CAN J VET RES | 1928-9022 | 88 | 2 | SCIE | VETERINARY SCIENCES | 2024 | 1.1 | 55.6 | 2 | THEILERIA-ORIENTALIS INFECTION; BORNE PATHOGENS | English | 2024 | 2024-04 | 바로가기 | 바로가기 | ||||||||||||||
| ○ | Article | Comparison of blood profiles between housed and grazing Korean indigenous cattle (Hanwoo) | The objective of this study was to compare the hematology profiles of Korean indigenous cattle (Hanwoo) raised in a barn (housed) or on pasture (grazing). Our findings showed significant differences in the red blood cell (RBC) profiles of these 2 groups. When compared to cattle raised in a barn, a significant decrease in hematocrit (P = 0.000), hemoglobin (P = 0.000), and red blood cells (RBCs) (P = 0.000) and a significant increase in mean cell volume (P = 0.015) and reticulocytes (P = 0.000) were observed in grazing cattle, which indicate regenerative anemia. Furthermore, indirect bilirubin was significantly higher in grazing cattle, which indicates intravascular hemolysis and neutropenia (P = 0.000), and monocytosis (P = 0.000) was also identified. To the best of our knowledge, this is the first study that demonstrates changes in reticulocyte count and indirect bilirubin levels secondary to regenerative intravascular hemolysis in grazing cattle. © 2024, Canadian Veterinary Medical Association. All rights reserved. | Kim, Youngjun; Ku, Ji-Yeong; Park, Kwang-Man; Baek, Jonghun; Choi, Kyoung-Seong; Park, Jinho | Department of Veterinary Internal Medicine, College of Veterinary Medicine, Jeonbuk University, Iksan, 54596, South Korea, Department of Animal Hospital, Hanwoo (Korean indigenous cattle) Genetic Improvement Center, National Agricultural Cooperative Federation, Seosan, 31948, South Korea; Department of Veterinary Internal Medicine, College of Veterinary Medicine, Jeonbuk University, Iksan, 54596, South Korea; Department of Veterinary Internal Medicine, College of Veterinary Medicine, Jeonbuk University, Iksan, 54596, South Korea; Department of Veterinary Internal Medicine, College of Veterinary Medicine, Jeonbuk University, Iksan, 54596, South Korea; Department of Animal Science and Biotechnology, College of Ecology and Environmental Science, Kyungpook National University, Sangju, 37224, South Korea; Department of Veterinary Internal Medicine, College of Veterinary Medicine, Jeonbuk University, Iksan, 54596, South Korea | 58845436500; 57753895700; 57219435315; 58986638200; 7403949556; 8730126700 | kschoi3@knu.ac.kr;jpark@jbnu.ac.kr; | Canadian Journal of Veterinary Research | CAN J VET RES | N/A | 1928-9022 | 88 | 2 | SCIE | VETERINARY SCIENCES | 2024 | 1.1 | 55.6 | 1.24 | 2025-05-07 | 2 | Animals; Bilirubin; Cattle; Cattle Diseases; Erythrocytes; Hemoglobins; Hemolysis; Republic of Korea; bilirubin; haptoglobin; hemoglobin; Article; blood analysis; dairy cattle; depression; enzyme linked immunosorbent assay; granulocyte; hematocrit; hematological parameters; leukocyte count; lymphocyte count; mean corpuscular volume; monocyte; nonhuman; physical activity; platelet distribution width; reticulocyte count; animal; bovine; cattle disease; erythrocyte; hemolysis; South Korea | English | Final | 2024 | 바로가기 | 바로가기 | ||||||||||
| ○ | ○ | Review | Is intensive chemotherapy and allogeneic stem cell transplantation mandatory for curing Philadelphia chromosome-positive acute lymphoblastic leukemia in young patients in the era of multitarget agents? | IntroductionThe treatment outcomes for Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) have improved with various tyrosine kinase inhibitors (TKIs) and bispecific T-cell engagers. Although allogeneic stem cell transplantation (allo-SCT) is the standard treatment for young patients with Ph+ALL, its role remains debatable in the era of TKIs and blinatumomab.Areas coveredThere are some issues regarding Ph+ALL. First, do young patients require intensive chemotherapy (IC) in the era of multitarget agents? Second, which TKI is preferred for frontline therapy? Third, should allo-SCT be performed in patients achieving complete remission with ponatinib and IC? Fourth, can chemo-free treatment lead to a cure without allo-SCT? We searched relevant literature from the last 30 years on PubMed; reviewed the role of chemo-free therapies and combinations of ponatinib and IC; and assessed the necessity of allo-SCT in young patients with Ph+ALL.Expert opinionAllo-SCT may not be needed, even in young patients with Ph+ALL treated with ponatinib-based IC or combined ponatinib and blinatumomab as frontline therapy. When adopting a ponatinib-based chemo-minimized regimen for induction, allo-SCT is needed with posttransplant ponatinib maintenance. Continuous exposure to ponatinib at pre- or post-transplant is regarded as one of the most important factor for the success of treatment. | Sohn, Sang Kyun; Lee, Jung Min; Jang, Youngeun; Lee, Yunji; Na, Jihyun; Cho, Hee Jeong; Moon, Joon Ho; Baek, Dong Won | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Hematol Oncol, 130 Dongdeok Ro, Daegu 41944, South Korea | Lee, Jung-Min/L-8227-2016 | 13310226800; 57211561890; 58300323200; 59135707500; 59136257000; 57216754907; 56568642700; 57191874272 | baekdw83@gmail.com; | EXPERT REVIEW OF HEMATOLOGY | EXPERT REV HEMATOL | 1747-4086 | 1747-4094 | 17 | 7 | SCIE | HEMATOLOGY | 2024 | 2.1 | 55.6 | 0.4 | 2025-04-16 | 1 | 1 | acute lymphoblastic leukemia; allogeneic stem cell transplantation; intensive chemotherapy; Philadelphia chromosome; ponatinib | VON-WILLEBRAND-FACTOR; THROMBOTIC THROMBOCYTOPENIC PURPURA; FACTOR-CLEAVING PROTEASE; UPSHAW-SCHULMAN-SYNDROME; HEMOLYTIC-UREMIC SYNDROME; ADAMTS13 GENE-MUTATIONS; FACTOR-VIII; RECOMBINANT ADAMTS13; MOLECULAR CHARACTERIZATION; VONWILLEBRAND-FACTOR | acute lymphoblastic leukemia; allogeneic stem cell transplantation; intensive chemotherapy; Philadelphia chromosome; ponatinib | Antibodies, Bispecific; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Hematopoietic Stem Cell Transplantation; Humans; Imidazoles; Molecular Targeted Therapy; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyridazines; Transplantation, Homologous; Treatment Outcome; blinatumomab; dasatinib; ponatinib; antineoplastic agent; bispecific antibody; blinatumomab; imidazole derivative; ponatinib; protein kinase inhibitor; pyridazine derivative; acute lymphoblastic leukemia; allogeneic stem cell transplantation; cancer chemotherapy; human; Philadelphia 1 chromosome; remission; Review; treatment outcome; allotransplantation; B cell acute lymphoblastic leukemia; hematopoietic stem cell transplantation; molecularly targeted therapy; multimodality cancer therapy; Philadelphia 1 chromosome; procedures; therapy | English | 2024 | 2024-07-02 | 10.1080/17474086.2024.2357273 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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