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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Review | Relationship between statins and the risk of amyotrophic lateral sclerosis A PRISMA-compliant meta-analysis | Objective: Previous studies on overlapping surveillance databases have suggested that statin use was associated with the development of amyotrophic lateral sclerosis (ALS)-like syndrome. However, the association between statin use and ALS incidence has not been clearly elucidated. To further explore this issue, we performed a systemic review and meta-analysis of all available clinical studies on the association between statin use and ALS incidence. Methods: A comprehensive database search on PubMed, Embase, Cochrane Library, and SCOPUS was conducted. We included studies up to January 31, 2020 that fulfilled our inclusion and exclusion criteria. Statin use between the ALS and control groups was collected for the meta-analysis. Results: Three case-control studies and 1 cohort study, that related the risk of ALS to statin use, satisfied the inclusion criteria for the meta-analysis. There was no statistically significant difference in statin use between the ALS and control groups (odds ratio, 0.75 [95% confidence interval, 0.53-1.08]). Conclusion: No definite association was found between statin use and the development of ALS. Further large-scale prospective randomized control studies are necessary to draw definite conclusions. | Chang, Min Cheol; Kwak, Sang Gyu; Park, Jin-Sung; Park, Donghwi | Yeungnam Univ, Coll Med, Dept Rehabil Med, Daegu, South Korea; Daegu Catholic Univ, Coll Med, Dept Med Stat, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Neurol, Daegu, South Korea; Univ Ulsan, Coll Med, Ulsan Univ Hosp, Dept Phys Med & Rehabil, 877 Bangeojinsunghwndo Ro, Ulsan 44033, South Korea | Park, Donghwi/GYQ-6185-2022; Kwak, Sang Gyu/AAG-4341-2021; Chang, Min Cheol/AAE-2321-2022 | 57991534800; 56645812600; 44061744500; 56606561400 | bdome@hanmail.net; | MEDICINE | MEDICINE | 0025-7974 | 1536-5964 | 100 | 30 | SCIE | MEDICINE, GENERAL & INTERNAL | 2021 | 1.817 | 71.2 | 0.34 | 2025-07-30 | 8 | 9 | amyotrophic lateral sclerosis; meta-analysis; statin | TERMINAL LATENCY; PREVALENCE; DISEASE; SAFETY | Amyotrophic lateral sclerosis; Meta-analysis; Statin | Amyotrophic Lateral Sclerosis; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; hydroxymethylglutaryl coenzyme A reductase inhibitor; amyotrophic lateral sclerosis; human; meta analysis | English | 2021 | 2021-07-30 | 10.1097/md.0000000000026751 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Ropivacaine continuous wound infusion after mastectomy with immediate autologous breast reconstruction A retrospective observational study | Continuous wound infusion usually provides postoperative analgesia as a multimodal analgesia with systemic opioid use. When continuous wound infusion of local anesthetics (LA) supports successful postoperative analgesia without systemic opioid use, the side effects of opioid can be reduced. Nevertheless, continuous wound infusion after mastectomy with immediate autologous breast reconstruction leads to concerns about wound healing. This study evaluated analgesic effects and wound healing conditions of continuous wound infusion of LA compared with opioid-based, intravenous patient-controlled analgesia (IV PCA) in mastectomy with immediate autologous breast reconstruction. This retrospective observational study included females, aged between 33 and 67 years, who underwent mastectomy with immediate autologous breast reconstruction. Sixty-five patients were enrolled. The eligible patients were placed into 2 groups for managing postoperative pain, one used continuous wound infusion with 0.5% ropivacaine (ON-Q, n = 32) and the other used a fentanyl-based IV PCA (IV PCA, n = 33). Using the electronic medical record system, the postoperative recovery profiles were examined over 5 days using a visual analogue scale (VAS), incidence of postoperative nausea and vomiting (PONV), incidence of sleep disturbance, frequency of rescue analgesic use, analgesia-related adverse events, length of hospital stay, and degree of patient satisfaction. The condition of the surgical wound was observed for 1 year after surgery. The primary endpoint was the intensity of pain at 6 hours after surgery. The VAS was comparable between the groups (P > .05). Although recovery profiles and the degree of patient satisfaction were similar between the groups, the incidence of PONV was significantly lower in the ON-Q group than in the IV PCA group on the day of surgery and postoperative day 1. No patients had severe wound complications. The satisfaction score of analgesia in the ON-Q group was comparable with that of the patients in the IV PCA group. This study demonstrates that single use of continuous wound infusion showed comparable analgesia with fentanyl-based IV PCA in patients who underwent mastectomy with immediate autologous breast reconstruction. Furthermore, the continuous infusion of LA directly on the surgical site did not significantly affect wound healing. | Lee, Jeong Eun; Park, Young Je; Lee, Jeong Woo | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Dept Anesthesiol & Pain Med, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Plast & Reconstruct Surg, Daegu, South Korea | 57224846206; 57224846209; 55892173700 | jeongwoo@knu.ac.kr; | MEDICINE | MEDICINE | 0025-7974 | 1536-5964 | 100 | 24 | SCIE | MEDICINE, GENERAL & INTERNAL | 2021 | 1.817 | 71.2 | 0.23 | 2025-07-30 | 2 | 2 | fentanyl; local anesthetics; mastectomy; postoperative pain | POSTOPERATIVE ANALGESIA; LOCAL-ANESTHETICS; PAIN; SURGERY; CANCER; PUMP; INFILTRATION; MANAGEMENT; CATHETERS; EFFICACY | fentanyl; local anesthetics; mastectomy; postoperative pain | Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Local; Breast Neoplasms; Female; Humans; Infusions, Intralesional; Length of Stay; Mammaplasty; Mastectomy; Middle Aged; Pain Management; Pain Measurement; Pain, Postoperative; Patient Satisfaction; Retrospective Studies; Ropivacaine; Surgical Wound; Treatment Outcome; Wound Healing; local anesthetic agent; narcotic analgesic agent; ropivacaine; adult; adverse event; aged; analgesia; breast reconstruction; breast tumor; complication; drug effect; female; human; intralesional drug administration; length of stay; mastectomy; middle aged; pain measurement; patient controlled analgesia; patient satisfaction; postoperative pain; procedures; retrospective study; surgical wound; treatment outcome; wound healing | English | 2021 | 2021-06-18 | 10.1097/md.0000000000026337 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Sinus pause during nerve integrity monitoring tube insertion following anesthetic induction with a low-dose neuromuscular blocking agent A CARE-compliant case report | Rationale: Nerve integrity monitoring (NIM) tubes are commonly used in thyroid surgery to prevent recurrent laryngeal nerve injury. To achieve the optimal electromyographic signal for NIM as intraoperative neural monitoring (IONM), the neuromuscular blocking agent (NMBA) dose should be low. The use of a low-dose NMBA increases the anesthetic and analgesic agent dose required to attenuate the laryngeal reflex during intubation. In addition, since the NMBA onset time is delayed, depending on the situation, anesthesia may become excessively deep or shallow before intubation. Patient's concern: A 51-year-old woman scheduled for thyroid lobectomy received 0.3 mg/kg of rocuronium. Three minutes later, when the NIM tube was inserted through the vocal cord, the patient's heart rate (HR) was undetectable for 2 seconds. Diagnosis: We suspected that the use of a high-dose anesthetic agent and remifentanil or the laryngocardiac reflex induced the sinus pause. Interventions: To maintain the anesthetic depth, we administered 6 vol% of desflurane. Because the patient's systolic blood pressure was 70 mmHg and HR was 30 beats/min, we discontinued the remifentanil infusion and administered 8 mg of ephedrine. Outcomes: The patient's vital signs recovered to normal levels. Subsequently, there were no episodes of bradycardia or arrhythmia. Conclusion: Sinus pause or severe bradycardia may occur due to the laryngocardiac reflex or the administration of a high-dose anesthetic and analgesic agent during tracheal intubation in patients who received a low-dose NMBA for IONM induction using an NIM tube. Anesthesiologists should be aware of these risks and take precautions to maintain adequate anesthesia, be prepared to administer vasoactive drugs to increase the blood pressure and HR if needed, and, if possible, intravenously administer lidocaine to attenuate the laryngeal reflex during intubation. | Byun, Sung-Hyey; Jeon, Jae-Min | Kyungpook Natl Univ, Sch Med, Dept Anesthesiol & Pain Med, Daegu, South Korea | Byun, Sung Hye/AEK-1234-2022 | 56921446300; 57251169500 | stone0311@naver.com; | MEDICINE | MEDICINE | 0025-7974 | 1536-5964 | 100 | 29 | SCIE | MEDICINE, GENERAL & INTERNAL | 2021 | 1.817 | 71.2 | 0 | 2025-07-30 | 0 | 0 | intraoperative nerve monitoring; intubation; neuromuscular blocking agents; onset time; sinus pause | RECURRENT LARYNGEAL NERVE; ROCURONIUM; DESFLURANE; PROPOFOL; REFLEX | intraoperative nerve monitoring; intubation; neuromuscular blocking agents; onset time; sinus pause | Anesthesia; Arrhythmias, Cardiac; Diagnosis, Differential; Female; Humans; Intraoperative Complications; Intubation, Intratracheal; Middle Aged; Neuromuscular Blocking Agents; Thyroidectomy; desflurane; ephedrine; lidocaine; propofol; remifentanil; rocuronium; neuromuscular blocking agent; adult; anesthesia induction; anesthesia level; anesthesiologist; Article; bag mask ventilation; bispectral index; blood pressure; blood pressure measurement; bradycardia; cancer patient; case report; clinical article; drug blood level; drug infusion; drug withdrawal; electrocardiography; endotracheal intubation; female; heart arrhythmia; heart rate; hemithyroidectomy; human; informed consent; laryngoscopy; larynx; low drug dose; middle aged; nerve integrity monitoring; neuromonitoring; outcome assessment; preoperative evaluation; sinus arrest; systolic blood pressure; thyroid papillary carcinoma; vital sign; vocal cord; adverse event; anesthesia; differential diagnosis; heart arrhythmia; peroperative complication; thyroidectomy | English | 2021 | 2021-07-23 | 10.1097/md.0000000000026683 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Step-by-step inpatient rehabilitation for critical illness after coronavirus disease 2019 A CARE-compliant case report | Introduction: Since the coronavirus disease (COVID-19) outbreak in Wuhan, China, in December 2019, COVID-19 has become a worldwide pandemic. Muscle weakness and deconditioning caused by COVID-19-induced critical illness requires rehabilitation. Patient concerns: A 74-year-old male patient complained of general weakness after COVID-19, requiring ventilator treatment. Diagnosis: He was confirmed as having COVID-19 using a polymerase chain reaction test. Interventions: During admission in the intensive care unit, medical staff wearing level D protective equipment performed the bedside manual range of motion exercise. After a negative COVID-19 test, the patient was transferred to a general ward, where sitting balance training and pulmonary rehabilitation were additionally performed by rehabilitation therapists wearing protective gear. When the patient was able to stand up with support, standing balance training and sit-to-stand training were performed. Outcomes: After a month of rehabilitation, the patient could sit alone, but he needed help with standing balance. The Berg Balance Scale score improved from 0 to 4, and the Modified Barthel Index score improved from 8 to 18. He was able to breathe in room air without an oxygen supply. Lessons: This case report shows an example of how safe and effective rehabilitation can be provided to COVID-19 patients. | Gwak, Dae-Won; Hwang, Jong-Moon | Kyungpook Natl Univ Hosp, Dept Rehabil Med, 130 Dongdeok Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Rehabil Med, Daegu, South Korea | 57212010177; 56367634000 | hti82@hanmail.net; | MEDICINE | MEDICINE | 0025-7974 | 1536-5964 | 100 | 23 | SCIE | MEDICINE, GENERAL & INTERNAL | 2021 | 1.817 | 71.2 | 0.11 | 2025-07-30 | 1 | 1 | coronavirus disease 2019; critical illness; deconditioning; intensive care unit; rehabilitation | COVID-19; MOBILIZATION; UNIT; ICU | Coronavirus disease 2019; Critical illness; Deconditioning; Intensive care unit; Rehabilitation | Aged; COVID-19; Critical Illness; Humans; Inpatients; Male; Physical Therapy Modalities; abduction; aged; ambient air; Article; artificial ventilation; Barthel index; Berg Balance Scale; case report; clinical article; computer assisted tomography; coronavirus disease 2019; coughing; COVID-19 testing; critical illness; critically ill patient; disease severity; dysphagia; dyspnea; fever; fluoroscopy; follow up; forced expiratory volume; forced vital capacity; general condition deterioration; geriatric rehabilitation; hospital patient; human; intensive care unit; lung function test; male; muscle atrophy; muscle strength; negative pressure ventilation; occupational therapist; occupational therapy; oxygen supply; patient isolation; physiotherapist; physiotherapy; polymerase chain reaction; poor general condition; pulmonary rehabilitation; quarantine; range of motion; rehabilitation medicine; resistance training; sitting; soft diet; sore throat; standing; thorax radiography; ventilator weaning; ward; critical illness; physiotherapy; rehabilitation | English | 2021 | 2021-06-11 | 10.1097/md.0000000000026317 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Synchronous gallbladder metastasis of renal cell carcinoma presenting as a gallbladder polyp A case report | Rationale: Gallbladder polyps are common in the general population, but gallbladder metastasis of renal cell carcinoma (RCC) is very rare. In a patient with RCC diagnosed with a small gallbladder polyp that does not meet the traditional size criteria, the surgeon faces a dilemma of whether cholecystectomy should be performed given the possibility of metastasis. Patient concerns: A 55-year-old man who had received a left nephrectomy for RCC presented with a gallbladder polyp that was noted at the time of the nephrectomy. Imaging showed the maximum diameter of the polyp had increased from 5 mm to 24 mm in the 40 months after the initial diagnosis. Diagnosis: Pathological and immunohistology findings confirmed the gallbladder polyp as a metastasis of clear-cell RCC. Interventions : We performed a laparoscopic cholecystectomy. Outcomes: Even though the synchronous solitary gallbladder metastasis was left untreated and a cholecystectomy was not performed over the 40 months, no metastasis occurred in other sites. The patient is free from disease 10 months after the cholecystectomy. Lessons: Solitary gallbladder metastasis of RCC may have more favorable outcomes than typical metastases. Although gallbladder metastasis of RCC occur rarely, it can occur, and any changes in gallbladder polyps in RCC patients should be managed under a strong suspicion of metastasis. | Cho, Sung Hoon; Han, Young Seok; Han, Ja Ryung; Kwon, Hyung Jun; Choi, Seock Hwan; Kim, Hyun Tae; Han, Man-Hoon; Chun, Jae Min | Kyungpook Natl Univ, Dept Surg, Kyungpook Natl Univ Hosp, Sch Med, 130 Dongdeok Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Dept Urol, Kyungpook Natl Univ Hosp, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Dept Pathol, Kyungpook Natl Univ Hosp, Sch Med, Daegu, South Korea | 57222033651; 59100011600; 57214671308; 57199757347; 59102081800; 55739531300; 57194067936; 24773178000 | cjmdr@knu.ac.kr; | MEDICINE | MEDICINE | 0025-7974 | 1536-5964 | 100 | 3 | SCIE | MEDICINE, GENERAL & INTERNAL | 2021 | 1.817 | 71.2 | 0.23 | 2025-07-30 | 0 | 2 | gallbladder polyp; metastasis; renal cell carcinoma | RISK-FACTORS; MANAGEMENT; PREVALENCE | gallbladder polyp; metastasis; renal cell carcinoma | Carcinoma, Renal Cell; Cholecystectomy; Gallbladder; Gallbladder Diseases; Gallbladder Neoplasms; Humans; Kidney Neoplasms; Laparoscopy; Male; Middle Aged; Nephrectomy; Polyps; case report; cholecystectomy; complication; gallbladder; gallbladder disease; gallbladder tumor; human; kidney tumor; laparoscopy; male; middle aged; nephrectomy; pathology; polyp; procedures; renal cell carcinoma | English | 2021 | 2021-01-22 | 10.1097/md.0000000000024037 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | A simple colorimetric detection of porcine epidemic diarrhea virus by reverse transcription loop-mediated isothermal amplification assay using hydroxynaphthol blue metal indicator | A simple reverse transcription loop-mediated isothermal amplification combined with visual detection method (vRT-LAMP) assay was developed for rapid and specific detection of porcine epidemic diarrhea virus (PEDV) in this study, which overcomes the shortcomings of previously described RT-LAMP assays that require additional detection steps or pose a risk of cross-contamination. The assay results can be directly detected by the naked eye using hydroxynaphthol blue after incubating for 40 min at 62 degrees C. The assay specifically amplified PEDV RNA and no other viral nucleic acids. The limit of detection of the assay was less than 50 RNA copies per reaction, which was 100 times more sensitive than conventional reverse transcription polymerase chain reaction (RT-PCR) and comparable to real-time RT-PCR (RRT-PCR). In the clinical evaluation, the PEDV detection rate of vRT-LAMP was higher than that of RRT-PCR, showing 99 % concordance, with a kappa value (95 % confidence interval) of 0.97 (0.93-1.01). Considering the advantages of high sensitivity and specificity, simple and direct visual monitoring of the results, no possibility for cross-contamination, and being able to be used as low-cost equipment, the developed vRT-LAMP assay will be a valuable tool for detecting PEDV from clinical samples, even in resource-limited laboratories. | Kim, Jae-Kyeom; Kim, Hye-Ryung; Kim, Da-Young; Kim, Jong-Min; Kwon, Na-Young; Park, Ji-Hoon; Park, Ji-Young; Kim, Seong-Hee; Lee, Kyoung-Ki; Lee, Changhee; Joo, Hoo-Don; Lyoo, Young S.; Park, Choi-Kyu | Kyungpook Natl Univ, Coll Vet Med, 80 Daehakro, Daegu 41566, South Korea; Kyungpook Natl Univ, Anim Dis Intervent Ctr, 80 Daehakro, Daegu 41566, South Korea; Anim & Plant Quarantine Agcy, Anim Dis Diagnost Div, Gimcheon 39660, South Korea; Kyungpook Natl Univ, Coll Nat Sci, BK21 Plus KNU Creat BioRes Grp, Sch Life Sci,Anim Virol Lab, Daegu 41566, South Korea; DIVA Bio Inc, Daegu 41519, South Korea; Konkuk Univ, Coll Vet Med, Seoul 05029, South Korea | 57277798700; 57195772612; 57195573426; 57277964700; 36561893400; 59872066600; 56095792500; 34769762800; 38163138800; 55700560700; 16230561400; 35501431200; 24768064900 | parkck@knu.ac.kr; | JOURNAL OF VIROLOGICAL METHODS | J VIROL METHODS | 0166-0934 | 1879-0984 | 298 | SCIE | BIOCHEMICAL RESEARCH METHODS;BIOTECHNOLOGY & APPLIED MICROBIOLOGY;VIROLOGY | 2021 | 2.623 | 71.5 | 0.9 | 2025-07-30 | 17 | 14 | Porcine epidemic diarrhea virus; Loop-mediated isothermal amplification; Visual detection | TRANSMISSIBLE GASTROENTERITIS VIRUS; REAL-TIME PCR; VISUAL DETECTION; DIAGNOSIS; STRAINS; PEDV; LAMP | Loop-mediated isothermal amplification; Porcine epidemic diarrhea virus; Visual detection | Animals; Colorimetry; Molecular Diagnostic Techniques; Naphthalenesulfonates; Nucleic Acid Amplification Techniques; Porcine epidemic diarrhea virus; Reverse Transcription; Sensitivity and Specificity; Swine; Swine Diseases; coronavirus nucleocapsid protein; hydroxynaphthol blue; indicator; nucleic acid; unclassified drug; virus RNA; naphthalenesulfonic acid derivative; trisodium 3-hydroxy-4-((2Z)-2-(2-oxo-4-sulfonatonaphthalen-1-ylidene)hydrazinyl)naphthalene-2,7-disulfonate; Article; clinical evaluation; colorimetry; confidence interval; contamination; controlled study; diagnostic test accuracy study; incubation time; intermethod comparison; kappa statistics; limit of detection; nonhuman; porcine epidemic diarrhea; Porcine epidemic diarrhea virus; process optimization; reaction temperature; reaction time; real time reverse transcription polymerase chain reaction; reverse transcription loop mediated isothermal amplification; reverse transcription polymerase chain reaction; sensitivity and specificity; virus detection; vision; animal; colorimetry; genetics; molecular diagnosis; nucleic acid amplification techniques; pig; procedures; reverse transcription; swine disease | English | 2021 | 2021-12 | 10.1016/j.jviromet.2021.114289 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Clinical usefulness of extraction-free PCR assay to detect SARS-CoV-2 | Due to the coronavirus disease 2019 pandemic, the demand for an easily accessible high-throughput screening test is increasing. We aimed to evaluate the usefulness of the extrac-tion-free polymerase chain reaction (PCR) as a screening test to detect severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Real-time reverse transcription PCR was performed in 300 samples (260 SARS-CoV-2 positives and 40 negatives), using both the conventional nucleic acid extraction method (standard method) and the direct method without nucleic acid extraction (direct method). The overall agreement between the standard and direct methods was 86.8 % (kappa 0.60), and the sensitivity of the direct method compared to the standard method was 85.4 %. When the cycle threshold (Ct) value was less than 35, the sensitivity was approximately 90 %-98 %, and when Ct exceeded 35, it decreased to approximately 60 %-65 %. The extraction-free PCR could be useful as a screening test that processes many samples in a short time. | Kim, Yu Kyung; Chang, Soon Hee | Kyungpook Natl Univ, Sch Med, Dept Clin Pathol, Daegu, South Korea | Kim, Young-Il/ISS-7678-2023 | 9237571900; 57222602055 | marta10@hanmail.net; | JOURNAL OF VIROLOGICAL METHODS | J VIROL METHODS | 0166-0934 | 1879-0984 | 296 | SCIE | BIOCHEMICAL RESEARCH METHODS;BIOTECHNOLOGY & APPLIED MICROBIOLOGY;VIROLOGY | 2021 | 2.623 | 71.5 | 0.9 | 2025-07-30 | 14 | 15 | SARS-CoV-2; COVID-19; Extraction-free PCR; Direct PCR; Crude method; No RNA extraction | COVID-19; Crude method; Direct PCR; Extraction-free PCR; No RNA extraction; SARS-CoV-2 | COVID-19; COVID-19 Testing; Humans; Real-Time Polymerase Chain Reaction; RNA, Viral; SARS-CoV-2; Sensitivity and Specificity; virus RNA; Article; controlled study; cycle threshold value; extraction free polymerase chain reaction; nonhuman; polymerase chain reaction; real time polymerase chain reaction; reverse transcription polymerase chain reaction; sensitivity analysis; Severe acute respiratory syndrome coronavirus 2; virus detection; diagnosis; genetics; human; isolation and purification; procedures; sensitivity and specificity; virology | English | 2021 | 2021-10 | 10.1016/j.jviromet.2021.114217 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Comparison of Early Surgical Treatment With Conservative Treatment of Incomplete Cervical Spinal Cord Injury Without Major Fracture or Dislocation in Patients With Pre-existing Cervical Spinal Stenosis | Study Design: This was a retrospective comparative study. Objective: The objective of this study was to evaluate the clinical outcomes of early surgical treatment (= 1 grade (90.9% vs. 57.1%, P=0.0051) and 2 grade (30.3% vs. 9.5%) improvements in ASIA grade. Multivariate analysis showed that treatment type, specifically early surgical treatment, was the only factor significantly associated with ASIA grade improvement after 2 years (P=0.0044). Conclusions: Early surgery yielded better neurological outcomes than conservative treatment in patients with incomplete CSCI without major fracture or dislocation and pre-existing CSCS. | Lee, Subum; Kim, Chunghwan; Ha, Jung-Ki; Jung, Sang Ku; Park, Jin Hoon | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Dept Neurosurg, Sch Med, Daegu, South Korea; Univ Ulsan, Gangneung Asan Hosp, Coll Med, Dept Orthoped Surg, Kangnung, South Korea; Univ Ulsan, Gangneung Asan Hosp, Dept Emergency Med, Coll Med, Kangnung, South Korea; Univ Ulsan, Asan Med Ctr, Dept Neurosurg, Coll Med, Seoul, South Korea | Lee, Subum/AFQ-2764-2022 | 57193631061; 57193155446; 56437869200; 35933363700; 36898773700 | jhpark@amc.seoul.kr; | CLINICAL SPINE SURGERY | CLIN SPINE SURG | 2380-0186 | 34 | 3 | SCIE | CLINICAL NEUROLOGY;ORTHOPEDICS | 2021 | 1.723 | 71.5 | 1.83 | 2025-07-30 | 13 | 16 | cervical spinal stenosis; conservative treatment; decompression; early surgery; incomplete spinal cord injury; spine trauma; neurological recovery; posterior cervical fusion | FOLLOW-UP; DECOMPRESSION; METHYLPREDNISOLONE; INTERVENTION; NALOXONE; SURGERY | cervical spinal stenosis; conservative treatment; decompression; early surgery; incomplete spinal cord injury; neurological recovery; posterior cervical fusion; spine trauma | Adult; Aged; Cervical Cord; Cervical Vertebrae; Conservative Treatment; Humans; Middle Aged; Retrospective Studies; Spinal Cord Injuries; Spinal Stenosis; Treatment Outcome; cephalosporin; levofloxacin; low molecular weight heparin; methylprednisolone; adult; American Spinal Injury Association impairment scale; Article; bladder irrigation; cervical spinal cord injury; cervical spine dislocation; cervical spine fracture; cervical spondylosis; clinical outcome; computer assisted tomography; conservative treatment; decompression surgery; deep vein thrombosis; falling; female; follow up; human; major clinical study; male; middle aged; nuclear magnetic resonance imaging; pneumonia; spine fusion; spine surgery; sport injury; surgical injury; traffic accident; urinary tract infection; vertebral canal stenosis; aged; cervical spinal cord; cervical vertebra; complication; conservative treatment; retrospective study; spinal cord injury; treatment outcome; vertebral canal stenosis | English | 2021 | 2021-04 | 10.1097/bsd.0000000000001065 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Comparison of Minimal Invasive Versus Biportal Endoscopic Transforaminal Lumbar Interbody Fusion for Single-level Lumbar Disease | Study Design: Retrospective study. Objective: The authors aimed to compare the clinical outcomes of biportal endoscopic transforaminal lumbar interbody fusion (BE-TLIF) with those of minimally invasive transforaminal lumbar interbody fusion (MI-TLIF) using a microscope. Summary of Background Data: Lumbar spinal fusion has been widely performed for various lumbar spinal pathologies. Minimally invasive transforaminal interbody fusion using a tubular retractor under a microscope is a method of achieving fusion while reducing soft tissue injury. Recently, several studies have reported minimally invasive techniques for lumbar discectomy, decompression, and interbody fusion using biportal endoscopic spinal surgery. Materials and Methods: This retrospective study included 87 patients who underwent single-level TLIF for degenerative or isthmic spondylolisthesis between 2015 and 2018. Thirty-two and 55 patients underwent BE-TLIF (group A) and MI-TLIF (group B), respectively. Visual Analogue Scale scores of the back and leg and Oswestry Disability Index were collected perioperatively. Further, data regarding perioperative complications, including length of hospital stay, time to ambulation, and fusion rate, were collected. Results: The Visual Analogue Scale score at 2 weeks and 2 months postoperatively was significantly lower in group A (P=0.001). All other clinical scores showed improvement with no significant difference between the 2 groups (P>0.05). The difference in the fusion rates between group A (93.7%) and group B (92.7%) were not significant (P=0.43). Conclusions: Because BE-TLIF yieldeds lesser early postoperative back pain than did MI-TLIF, it may allow early ambulation and a shorter hospitalization period. BE-TLIF may be a viable alternative to MI-TLIF in patients with degenerative or isthmic spondylolisthesis with superior clinical results in the early postoperative period. | Kim, Ju-Eun; Yoo, Hyun-Seung; Choi, Dae-Jung; Park, Eugene J.; Jee, Seung-Min | Himnaera Hosp, Dept Orthoped Surg, Pusan, South Korea; Fatima Hosp, Dept Orthoped Surg, ASI KR KS002, Daegu, South Korea; Kyungpook Natl Univ Hosp, Dept Orthoped Surg, Daegu, South Korea | Park, Eugene/P-1473-2018 | 56487007900; 57217302438; 57061435000; 55371642100; 57217303841 | brianyoo82@naver.com; | CLINICAL SPINE SURGERY | CLIN SPINE SURG | 2380-0186 | 34 | 2 | SCIE | CLINICAL NEUROLOGY;ORTHOPEDICS | 2021 | 1.723 | 71.5 | 10.84 | 2025-07-30 | 86 | 100 | transforaminal interbody fusion; endoscopy; spinal stenosis; degenerative spinal disease | degenerative spinal disease; endoscopy; spinal stenosis; transforaminal interbody fusion | Humans; Lumbar Vertebrae; Minimally Invasive Surgical Procedures; Retrospective Studies; Spinal Fusion; Spondylolisthesis; Treatment Outcome; aged; Article; biportal endoscopic transforaminal lumbar interbody fusion; bone radiography; claudication; comparative study; computer assisted tomography; degenerative disease; discectomy; female; fluoroscopy; hematoma; human; intervertebral disk; laminectomy; longissimus muscle; low back pain; lumbar spine; major clinical study; male; medical procedures; minimally invasive procedure; nerve ending; numeric rating scale; operation duration; osteotomy; Oswestry Disability Index; peroperative complication; questionnaire; radiography; retrospective study; skin incision; soft tissue injury; spondylolisthesis; stenosis; visual analog scale; diagnostic imaging; lumbar vertebra; minimally invasive surgery; spine fusion; spondylolisthesis; treatment outcome | English | 2021 | 2021-03 | 10.1097/bsd.0000000000001024 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Genetic and phylogenetic analysis of porcine circovirus type 2 on Jeju Island, South Korea, 2019-2020: evidence of a novel intergenotypic recombinant | Porcine circovirus type 2 (PCV2) is the most ubiquitous viral pathogen of pigs and has persistently affected the global swine industry. Since first being identified in South Korea in 1999, the virus has undergone considerable genetic change and genotype shifts during the past two decades. These events have contributed to the coexistence of genotypes PCV2a, PCV2b, and PCV2d in Korean pig populations, which may promote viral recombination. The genotypic and phylogenetic characteristics of PCV2 strains circulating in pig herds on Jeju Island from 2019 to 2020 were the focus of this study. Genotype-specific PCR indicated that PCV2d is the dominant viral genotype and that coinfections with PCV2d and PCV2a (75%) or PCV2a and PCV2b (25%) are common in provincial pig herds. The complete genome sequences of 11 PCV2 strains, including three PCV2a, two PCV2b, and six PCV2d strains, were determined. A genomic comparison showed that all of the viruses had the highest nucleotide sequence identity to their corresponding genotypic reference strain. Notably, genetic and phylogenetic analysis revealed that one PCV2d strain, KNU-1931, exhibited nucleotide sequence variation in the ORF1 gene when compared to other PCV2d strains but showed a high degree of similarity to the PCV2b strains. Comprehensive recombination analysis suggested that KNU-1931 originated from natural recombination within ORF1 between PCV2b (the minor parent) and PCV2d (the major parent) strains. Our findings provide information about the frequency of genetic recombination between two different PCV2 genotypes circulating in the field domestically, illustrating the importance of continual intergenotypic recombination for viral fitness when multiple genotypes are present. | Jang, Guehwan; Yoo, Hyekyung; Kim, Yeeun; Yang, Kyungsu; Lee, Changhee | Kyungpook Natl Univ, Anim Virol Lab, BK21 FOUR KNU Creat BioRes Grp, Sch Life Sci,Coll Nat Sci, Daegu 41566, South Korea; Farm & Pharm Vet Hosp, Jeju 63029, South Korea | 56608747100; 57208907611; 57221955576; 57216744385; 55700560700 | changhee@knu.ac.kr; | ARCHIVES OF VIROLOGY | ARCH VIROL | 0304-8608 | 1432-8798 | 166 | 4 | SCIE | VIROLOGY | 2021 | 2.685 | 71.6 | 0.97 | 2025-07-30 | 14 | 14 | Animals; Circoviridae Infections; Circovirus; DNA, Viral; Genetic Variation; Genome, Viral; Genotype; Islands; Nucleic Acid Hybridization; Phylogeny; Recombination, Genetic; Republic of Korea; Sequence Analysis, DNA; Swine; Swine Diseases; virus DNA; animal; Circoviridae infection; Circovirus; classification; DNA sequence; genetic recombination; genetic variation; genetics; genotype; island (geological); isolation and purification; nucleic acid hybridization; phylogeny; pig; South Korea; swine disease; veterinary medicine; virology; virus genome | English | 2021 | 2021-04 | 10.1007/s00705-020-04948-1 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Prospective, Randomized, Comparative, Multicenter Study of the Hybrid Ultrasonic Advanced Bipolar Device and the Ultrasonic Coagulating Shears in Open Thyroidectomy | Background.The hybrid ultrasonic advanced bipolar device (HUB) that integrates ultrasonic energy and advanced bipolar energy was recently developed and applied to thyroid surgery. The purpose of this study was to compare the efficacy and safety of HUB and ultrasonic coagulating shears for open thyroidectomy.Methods.A total of 200 patients were enrolled from April to September 2017 in this prospective, randomized, multicenter study. Patients were randomly assigned to an ultrasonic group (n = 101) or a hybrid group (n = 99).Results.Operation times were similar in the 2 study groups, that is, 54.2 +/- 25.2 minutes in the ultrasonic group and 50.2 +/- 21.6 minutes in the hybrid group. Postoperative surgical results and morbidities were no different in the 2 groups. However, the total amount of bleeding was significantly less in the hybrid group (13.0 +/- 17.7 mg vs 8.6 +/- 11.5 mg;P= .042).Conclusions.Our study showed that there was no significant difference between the 2 groups in postoperative surgical results and morbidity. The total bleeding amount was significantly less in the hybrid group. The study shows that HUB is comparable to the ultrasonic coagulating shears in terms of efficacy and safety during thyroid surgery. | Kim, Wan Wook; Cho, Jihyoung; Jeon, Young San; Kim, Insoo; Jeong, Young Ju; Choi, Jungeun; Lee, Moo Hyun; Lee, Jehyung; Kang, Jin Gu; Tufano, Ralph P.; Kang, Su Hwan | Kyungpook Natl Univ, Sch Med, Dept Surg, Daegu, South Korea; Keimyung Univ, Sch Med, Dept Surg, Daegu, South Korea; Goo Hosp, Dept Surg, Daegu, South Korea; Daegu Fatima Hosp, Dept Surg, Daegu, South Korea; Catholic Univ Daegu, Sch Med, Dept Surg, Daegu, South Korea; Yeungnam Univ, Dept Surg, Coll Med, Daegu, South Korea; Johns Hopkins Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Baltimore, MD 21205 USA | Kim, Insoo/X-5843-2019 | 26023273400; 35409073500; 36137095700; 57218439041; 55432430600; 56327120300; 57208629747; 57218438663; 57212657779; 7006462546; 57217378204 | kangsuhwan@yu.ac.kr; | SURGICAL INNOVATION | SURG INNOV | 1553-3506 | 1553-3514 | 28 | 1 | SCIE | SURGERY | 2021 | 1.785 | 71.6 | 0.66 | 2025-07-30 | 5 | 5 | comparison; energy-based device; ultrasonic coagulating shears; hybrid ultrasonic advanced bipolar device; thyroidectomy | RECURRENT LARYNGEAL NERVE; HARMONIC SCALPEL; THUNDERBEAT; SURGERY; FOCUS; LIGASURE; INJURY; SAFETY; TIE | comparison; energy-based device; hybrid ultrasonic advanced bipolar device; thyroidectomy; ultrasonic coagulating shears | Bipolar Disorder; Electrocoagulation; Humans; Prospective Studies; Thyroidectomy; Ultrasonic Therapy; Ultrasonics; calcitriol; calcium; calcium carbonate; parathyroid hormone; adult; aortic constriction; Article; aspiration; bleeding; body mass; calcium blood level; clinical trial; comparative study; controlled study; echography; female; hospital discharge; hospitalization; human; hypocalcemia; hypoparathyroidism; laryngoscopy; limb paralysis; lobectomy; lymph node metastasis; major clinical study; male; morbidity; multicenter study; multiple cancer; operation duration; parathyroidectomy; postoperative complication; randomized controlled trial; recurrent laryngeal nerve palsy; seroma; skin incision; thyroid cancer; thyroid surgery; thyroidectomy; thyroiditis; ultrasound; wound infection; adverse event; bipolar disorder; electrocoagulation; prospective study; thyroidectomy; ultrasound therapy | English | 2021 | 2021-02 | 10.1177/1553350620949000 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Real hypersurfaces in the complex hyperbolic quadric with normal Jacobi operator of Codazzi type | In this paper, we introduce the notion of normal Jacobi operator of Codazzi type for real hypersurfaces in the complex hyperbolic quadric Q(m)* = SO2,mo /SO2SOm. The normal Jacobi operator of Codazzi type implies that the unit normal vector field N becomes A-principal or A-isotropic. Then according to each case, we give a complete classification of Hopf real hypersurfaces in Q(m)* = SO2,mo /SO2SOm with normal Jacobi operator of Codazzi type. The result of the classification shows that no such hypersurfaces exist. | Jeong, Imsoon; Pak, Eunmi; Suh, Young Jin | Cheongju Univ, Dept Math Educ, Chungcheongbuk Do 28503, South Korea; Kyungpook Natl Univ, Dept Math, Daegu 41566, South Korea; Kyungpook Natl Univ, RIRCM, Daegu 41566, South Korea | 24461853600; 55850401400; 7202260479 | isjeong@cju.ac.kr;empak@knu.ac.kr;yjsuh@knu.ac.kr; | INTERNATIONAL JOURNAL OF MATHEMATICS | INT J MATH | 0129-167X | 1793-6519 | 32 | 14 | SCIE | MATHEMATICS | 2021 | 0.708 | 71.6 | 0.22 | 2025-07-30 | 1 | 1 | Normal Jacobi operator of Codazzi type; A-isotropic; A-principal; Kahler structure; complex conjugation; complex quadric | EINSTEIN HYPERSURFACES; 2-PLANE GRASSMANNIANS; PROJECTIVE-SPACE; RICCI TENSOR | Complex conjugation; Complex quadric; Isotropic; Kähler structure; Normal Jacobi operator of Codazzi type; Principal | English | 2021 | 2021-12 | 10.1142/s0129167x21501056 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Direct comparison of F-18 FDG PET/CT and MRI to predict pathologic response to neoadjuvant treatment in locally advanced rectal cancer: a meta-analysis | Objective The purpose of the current study was to compare the diagnostic accuracies of F-18 FDG PET/CT and MRI for prediction of pathologic responses to neoadjuvant treatment (NAT) in locally advanced rectal cancer (LARC) patients based on a systematic review and meta-analyses. Methods The PubMed, Cochrane, and Embase databases were searched to identify studies that conducted direct comparisons of the diagnostic performance of F-18 FDG PET/CT and MRI for the prediction of pathologic response to NAT in patients with LARC from the earliest available date of indexing up to July 31, 2020. We determined the sensitivities and specificities across studies, calculated positive and negative likelihood ratios (LR + and LR -), and we constructed summary receiver operating characteristic curves. Results In nine studies (427 patients), the pooled sensitivity of F-18 FDG PET/CT was 0.79 (95% CI 0.71-0.86) and the pooled specificity was 0.74 (95% CI 0.60-0.84). LR syntheses yielded an overall LR + of 3.1 (95% CI 1.9-5.0) and an LR - of 0.28 (95% CI 0.18-0.43). The pooled diagnostic odds ratio (DOR) was 11 (95% CI 5-26). The pooled sensitivity of MRI was 0.89 (95% CI 0.77-0.95) and the pooled specificity was 0.66 (95% CI 0.55-0.76). LR syntheses yielded an overall LR + of 2.6 (95% CI 1.9-3.6) and an LR - of 0.17 (95% CI 0.08-0.37). The pooled DOR was 15 (95% CI 6-42). In meta-regression analysis, no variable was identified as the source of the study heterogeneity. Conclusion F-18 FDG PET/CT and MRI showed similar diagnostic performances for the prediction of pathologic responses to NAT in patients with LARC. However, each modality can be a complement to other rather than being used singly. | Lee, Sang-Woo; Jeong, Shin Young; Kim, Keunyoung; Kim, Seong-Jang | Kyungpook Natl Univ, Dept Nucl Med, Chilgok Hosp, Daegu 41404, South Korea; Sch Med, Daegu 41404, South Korea; Pusan Natl Univ Hosp, Dept Nucl Med, Busan 49241, South Korea; Pusan Natl Univ, Dept Nucl Med, Coll Med, Yangsan Hosp, Yangsan 50612, South Korea; Pusan Natl Univ, BioMed Res Inst Convergence Biomed Sci & Technol, Yangsan Hosp, Yangsan 50612, South Korea | Kim, Yun Hak/ABF-3331-2021; Kim, Dong/I-7600-2015; lee, sangwoo/KUD-1906-2024 | 57196249819; 36164032500; 36523010700; 35810391700 | swleenm@knu.ac.kr;syjeong@knu.ac.kr;nmpnuh@gmail.com;growthkim@pusan.ac.kr; | ANNALS OF NUCLEAR MEDICINE | ANN NUCL MED | 0914-7187 | 1864-6433 | 35 | 9 | SCIE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | 2021 | 2.258 | 71.7 | 0.45 | 2025-07-30 | 5 | 4 | F-18 FDG; PET; CT; MRI; Pathologic response; LARC; NAT | DIAGNOSTIC-TEST ACCURACY; CONTRAST-ENHANCED-MRI; BREAST-CANCER; CHEMORADIOTHERAPY; CHEMOTHERAPY; CHEMORADIATION; THERAPY; RADIATION; PET/MRI; BIAS | F-18 FDG; LARC; MRI; NAT; Pathologic response; PET/CT | Fluorodeoxyglucose F18; Humans; Neoadjuvant Therapy; Positron Emission Tomography Computed Tomography; Rectal Neoplasms; bevacizumab; capecitabine; capecitabine plus oxaliplatin; fluorodeoxyglucose f 18; fluorouracil; folinic acid; gimeracil plus oteracil potassium plus tegafur; irinotecan; oxaliplatin; fluorodeoxyglucose f 18; adult; advanced cancer; Article; comparative study; controlled study; diagnostic accuracy; diagnostic test accuracy study; female; human; male; meta analysis; neoadjuvant therapy; nuclear magnetic resonance imaging; positron emission tomography-computed tomography; predictive value; quality control; rectum cancer; sensitivity and specificity; systematic review; neoadjuvant therapy; positron emission tomography-computed tomography; rectum tumor | English | 2021 | 2021-09 | 10.1007/s12149-021-01639-y | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Review | Conflicting Drivers of Virtual Water Trade: A Review Based on the "Virtual Water Concept" | The virtual water concept has been largely applied in the study of regional, national, and global water flows with particular emphasis on water endowment. Despite water traditionally being managed locally, certain forces (drivers) influence the local water resource availability and hence virtual water exchanges. This study reviews available literature to determine those drivers and their influence on virtual water exchanges. Studies show that the drivers are numerous, and there exist several available literatures providing controversial results leading to a high level of uncertainty in the determination of their relative significance. Possible reasons for the contradicting results are discussed and suggestions made. | Odey, Golden; Adelodun, Bashir; Kim, Sang Hyun; Choi, Kyung Sook | Kyungpook Natl Univ, Dept Agr Civil Engn, Daehak Buk, Daegu, South Korea; Univ Ilorin, Dept Agr & Biosyst Engn, PMB 1515, Ilorin, Nigeria; Kyungpook Natl Univ, Inst Agr Sci & Technol, Daehak Buk, Daegu, South Korea | Adelodun, Bashir/O-2941-2018; Odey, Golden/MVV-6310-2025 | 57211444984; 57193774482; 57211805802; 54392662900 | goldenodey@knu.ac.kr;adelodun.b@unilorin.edu.ng;sangddong2@gmail.com;ks.choi@knu.ac.kr; | WATER ECONOMICS AND POLICY | WATER ECON POLICY | 2382-624X | 2382-6258 | 07 | 03 | SSCI;SCIE | ECONOMICS;ENVIRONMENTAL STUDIES;WATER RESOURCES | 2021 | 1.333 | 71.8 | 0.74 | 2025-07-30 | 13 | 11 | Water endowment; virtual water trade; environmental and socioeconomic drivers; trade determinants | HETAO IRRIGATION DISTRICT; FOOTPRINT; FLOWS; CONSUMPTION; FOOD; GLOBALIZATION; RESOURCES; ECONOMICS; PRODUCTS; PATTERNS | environmental and socioeconomic drivers; trade determinants; virtual water trade; Water endowment | English | 2021 | 2021-07 | 10.1142/s2382624x21500119 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Resistome and microbial profiling of pediatric patient's gut infected with multidrug-resistant diarrhoeagenic Enterobacteriaceae using next-generation sequencing; the first study from Pakistan | A high prevalence of multidrug-resistant (MDR) pathogens has been reported in adult and pediatric populations of Pakistan. However, data describing the effect of MDR microbes on the gut microbiota is scarce. We designed a cross-sectional pediatric study to investigate the effect of MDR microbes' infection on the gut microbiome and its resistome of children using high-throughput next-generation sequencing (NGS). A cross-sectional study was conducted at a tertiary health care hospital in Peshawar Pakistan, between 5 September 2019 to 15 February 2020. Pediatric patients with acute gastroenteritis (n = 200) were enrolled. All the enrolled pediatric patients underwent initial antimicrobial resistance (AMR) screening using the disk diffusion method. Children with MDR infections were identified and selected for gut microbiome and its resistome profiling using NGS. Out of 200 enrolled pediatric patients, 80 (40%) were found infected with MDR diarrheagenic Enterobacteriaceae consisting of 50 (62.5%) infections caused by extended-spectrum beta-lactamase (ESBL) producing E. coli while 30 (37.5%) by MDR Enterobacter specie. A total of 63 and 17 antibiotic-resistant genes (ARGs) conferring resistance to 7 and 5 classes of antibiotics were identified in the resistomes of MDR diarrheagenic Enterobacteriaceae infected and healthy children, respectively. NGS-based gut microbial profiling of MDR Enterobacter spp., ESBL producing E. coli infected pediatric patients and healthy controls revealed the predominance of Proteobacteria and Actinobacteria, respectively. An increased abundance of several pathogenic gram-negative bacteria namely E. coli, Enterobacter cloacae, and Salmonella enterica was observed in the gut microbiota of children infected with MDR bacterial infections than that of the healthy controls. This work indicates that children with MDR infections have reduced microbial diversity and enriched ARGs than healthy controls. The emergence of MDR bacterial strains and their association with gut dysbiosis needs immediate attention to regulate antibiotics usage in Pakistani children. | Afridi, Ome Kalsoom; Ali, Johar; Chang, Jeong Ho | Kyungpook Natl Univ, Dept Biol Educ, 80 Daehak Ro, Daegu 41566, South Korea; Rehman Med Inst Peshawar, Ctr Genome Sci, Khyber Pakhtunkhwa 25000, Pakistan; Sukkur Inst Business Adm Univ, Execut Dev Ctr, Sindh 65200, Pakistan; CECOS Univ IT & Emerging Sci, Inst Integrat Biosci, Dept Biotechnol, Peshawar 25000, Pakistan | 57218250521; 57213890686; 57203598905 | Johar.ali1@rmi.edu.pk;jhcbio@knu.ac.kr; | LIBYAN JOURNAL OF MEDICINE | LIBYAN J MED | 1993-2820 | 1819-6357 | 16 | 1 | SCIE | MEDICINE, GENERAL & INTERNAL | 2021 | 1.743 | 71.8 | 0.46 | 2025-07-30 | 4 | 6 | Multidrug resistance; shotgun metagenomic sequencing; resistome diversities; pediatric patients; superbug; dysbiosis | dysbiosis; Multidrug resistance; pediatric patients; resistome diversities; shotgun metagenomic sequencing; superbug | Anti-Bacterial Agents; Child, Preschool; Cross-Sectional Studies; Diarrhea; Drug Resistance, Multiple, Bacterial; Enterobacteriaceae; Female; Gastroenteritis; Gastrointestinal Microbiome; Gram-Negative Bacteria; High-Throughput Nucleotide Sequencing; Humans; Male; Microbial Sensitivity Tests; Pakistan; aminoglycoside antibiotic agent; beta lactam antibiotic; lincosamide; macrolide; polypeptide antibiotic agent; quinoline derived antiinfective agent; rifampicin; streptogramin derivative; tetracycline; tetracycline derivative; antiinfective agent; acrA gene; acrB gene; acrD gene; acrE gene; acrF gene; Actinobacteria; acute gastroenteritis; AGlyRmtB gene; AGlyStrB gene; antibiotic resistance; antibiotic resistome; APH [6] Id gene; APH6 gene; Article; bacA gene; bacterial gene; baeR gene; baeS gene; blaAZECL 25 gene; blaCMH 2 gene; blaCMH 3 gene; blaCTX M 101 gene; blaTEM 116 gene; child; controlled study; CpxA gene; cross-sectional study; CRP gene; CTX M 107 gene; disk diffusion; emrA gene; emrB gene; emrR gene; emrY gene; Enterobacter cloacae; Enterobacteriaceae infection; ermX gene; Escherichia coli; extended spectrum beta lactamase producing Escherichia coli; H NS gene; high throughput sequencing; human; intestine flora; KdpE gene; lnuC gene; major clinical study; marA gene; mdtA gene; mdtB gene; mdtC gene; mdtE gene; mdtF gene; mdtG gene; mdtH gene; mdtK gene; mefA gene; microbial diversity; MIR 13 gene; msbA gene; MsrC gene; MsrD gene; multidrug resistant diarrhoeagenic Enterobacteriaceae; multidrug resistant Enterobacter; multidrug resistant Enterobacteriaceae; Pakistan; pmrF gene; population abundance; Proteobacteria; QnrS1 gene; rmtB1 gene; rpoB gene; rpoB2 gene; Salmonella enterica; tertiary care center; tet34 gene; tetA gene; tetA46 gene; tetM gene; tetO gene; tetW gene; ugd gene; yojI gene; diarrhea; Enterobacteriaceae; female; gastroenteritis; genetics; Gram negative bacterium; high throughput sequencing; isolation and purification; male; microbial sensitivity test; microbiology; multidrug resistance; preschool child | English | 2021 | 2021-01-01 | 10.1080/19932820.2021.1915615 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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