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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Clinical features and prognostic factors of critically ill patients with COVID-19 in Daegu, South Korea A multi-center retrospective study | To describe the clinical and demographic characteristics of critically ill patients with COVID-19 in Daegu, South Korea, and to explore the risk factors for in-hospital mortality in these patients. Retrospective cohort study of 110 critically ill patients with COVID-19 admitted to the ICU in Daegu, South Korea, between February 18 and April 5, 2020. The final date of follow-up was April 20, 2020. A total of 110 patient medical records were reviewed. The median age was 71 years (interquartile range [IQR] = 63-78 years). During the study period, 47 patients (42.7%) died in the hospital. The most common SARS-CoV-2 infection related complication was acute respiratory distress syndrome (ARDS) in 95 patients (86.4%). Of the 79 patients (71.8%) who received invasive mechanical ventilation, 46 (58.2%) received neuromuscular blockade injection, and 19 (24.1%) received ECMO treatment. All patients received antibiotic injection, 99 patients (90%) received hydroxychloroquine, 96 patients (87.3%) received lopinavir-ritonavir antiviral medication, and 14 patients (12.7%) received other antiviral agents, including darunavir-cobicistat and emtricitabine-tenofovir. In the multivariable logistic regression model, the odds ratio of in-hospital death was higher with APACHE II score (OR = 1.126; 95% CI = 1.014-1.252; P = .027). The in-hospital mortality rate of critically ill patients with COVID-19 was approximately 40%. Higher APACHE II score at admission was an independent risk factor for death in these patients. | Kim, Eun Jin; Lee, Yong Hoon; Park, Jae Seok; Lee, Jaehee; Lee, Shin Yup; Kim, Yeonjae; Kwon, Yong Shik; Jang, Jong Geol; Shin, Kyeong-Cheol; Kim, Kyung Chan; Choi, Eun Young | Daegu Catholic Univ Hosp, Div Pulm & Crit Care Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Keimyung Univ, Dept Internal Med, Div Pulmonol, Dongsan Hosp,Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Div Pulm & Crit Care Med, Chilgok Hosp, Daegu, South Korea; Deagu Fatima Hosp, Div Pulm & Crit Care Med, Daegu, South Korea; Yeungnam Univ, Div Pulm & Crit Care Med, Med Ctr, Daegu, South Korea | Lee, Yoojin/AAB-9799-2022; Lee, Jeong-Hoon/Q-1055-2018; Lee, Jaehee/S-1697-2018; Kim, Eun/AAS-6706-2020; Kim, Eun Jin/L-6480-2018 | 55927957400; 57199022948; 8866846500; 13805476000; 49863712700; 56066688300; 57203804743; 56645456400; 35320479500; 55667010800; 57190418295 | letact@yu.ac.kr; | MEDICINE | MEDICINE | 0025-7974 | 1536-5964 | 100 | 7 | SCIE | MEDICINE, GENERAL & INTERNAL | 2021 | 1.817 | 71.2 | 0.8 | 2025-07-30 | 7 | 7 | COVID-19; critically ill | COVID-19; critically ill | Age Factors; Aged; Aged, 80 and over; APACHE; Comorbidity; COVID-19; Critical Illness; Drosophila Proteins; Extracorporeal Membrane Oxygenation; Female; Hospital Mortality; Humans; Male; Membrane Proteins; Middle Aged; Prognosis; Republic of Korea; Respiration, Artificial; Retrospective Studies; Risk Factors; SARS-CoV-2; Drosophila protein; ex protein, Drosophila; membrane protein; age; aged; APACHE; artificial ventilation; clinical trial; comorbidity; critical illness; epidemiology; extracorporeal oxygenation; female; hospital mortality; human; male; middle aged; mortality; multicenter study; procedures; prognosis; retrospective study; risk factor; South Korea; very elderly | English | 2021 | 2021-02-19 | 10.1097/md.0000000000024437 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Comparative analysis of the recent publication trends in 4 representative journals in the spine field | We have analyzed and compared the publication trends in 4 representative spinal journals [Spine, European Spinal Journal (EUS), The Spine Journal (TSJ), and the Journal of Neurosurgery - Spine (JNS spine)] from 2016 to 2018. A total of 3784 articles were published in the 4 representative journals: 1358, 1128, 685, and 613 articles in Spine, EUS, TSJ, and JNS spine, respectively. We compared and analyzed each periodical for the time taken (days) for the publication process, the distribution of specialties of the corresponding author, multicity of the investigative institutions, main disease entity, study type, and design. The period from submission to online publication was 133, 216, 181, and 318 days in Spine, EUS, TSJ, and JNS spine, respectively. Corresponding authors with orthopedic specialties were more common in Spine, EUS, and TSJ than in JNS spine. Of particular note, corresponding authors who were neurosurgeons were the majority (55.8%) only in JNS spine. Single institution articles were by far the most common (average 92.8%) in all 4 journals. In all of the analyzed journals, the proportion of degenerative diseases was dominant with an average of 44.9%. The most frequent study type in all 4 journals was a clinical article (79.6, 72.1, 63.3, and 63.1%, respectively). In general, meta-analyses (average 4%) and randomized controlled comparative studies (average 5.2%) accounted for a very low percentage of the study types. We believe that periodic analyses and comparisons of the characteristics of representative spine journals will help to shape the direction of future improvements. | Yang, Kuhyun; Baek, Hong-Gyu; Cho, Dae-Chul; Jung, Yoon Gyo; Lee, Subum; Park, Jin Hoon | Univ Ulsan, Coll Med, Gangneung Asan Hosp, Dept Neurosurg, Gangneung Si, Gangwon Do, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Dept Neurosurg, Sch Med, 130 Dongduk Ro, Daegu 41944, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Neurosurg, Seoul, South Korea | Lee, Subum/AFQ-2764-2022; Jung, Yoon/HRA-4310-2023 | 56203127700; 57210117613; 55859543400; 57216843080; 57193631061; 36898773700 | sblee0512@gmail.com; | MEDICINE | MEDICINE | 0025-7974 | 1536-5964 | 100 | 45 | SCIE | MEDICINE, GENERAL & INTERNAL | 2021 | 1.817 | 71.2 | 0.11 | 2025-07-30 | 1 | 1 | European Spinal Journal; Journal of Neurosurgery; Spine; publication; Spine; The Spine Journal | European Spinal Journal; Journal of Neurosurgery - Spine; publication; Spine; The Spine Journal | Bibliometrics; Humans; Neurosurgery; Neurosurgical Procedures; Orthopedics; Periodicals as Topic; Spine; Article; clinical article; comparative study; controlled study; degenerative disease; feedback system; human; medical specialist; neoplasm; neurosurgeon; neurosurgery; online analysis; orthopedic surgeon; orthopedics; publication; randomized controlled trial (topic); scientific literature; spine; spine surgery; study design; time to treatment; bibliometrics; orthopedics; randomized controlled trial; spine | English | 2021 | 2021-11-12 | 10.1097/md.0000000000027716 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Comparison of nutrition and quality of life of esophagogastrostomy and the double-tract reconstruction after laparoscopic proximal gastrectomy | This study aims to compare the nutritional outcomes and quality of life between patients who underwent esophagogastrostomy (EG) and those who underwent the double-tract reconstruction (DTR) after laparoscopic proximal gastrectomy for early gastric cancer. We retrospectively reviewed the prospectively established database of 45 patients who underwent EG with anti-reflux procedure and 58 patients who underwent the DTR after laparoscopic proximal gastrectomy between December 2013 and June 2017. Then, we compared the baseline characteristics, clinical outcomes, postoperative nutritional parameters, and quality of life (QOL) using European Organization for Research and Treatment of Cancer (EORTC) QLQ STO-22 between the EG and DTR groups. In the postoperative 1-year endoscopic findings, the incidence of esophageal reflux was higher in the EG group (17.8% vs 3.4%, P = .041) and there was no significant difference in anastomotic stricture. Nutritional status was evaluated via body mass index, serum albumin, protein, hemoglobin, and ferritin; we found no significant differences. The incidences of iron deficiency anemia and vitamin B12 deficiency also showed no significant difference between the 2 groups. With regards to the quality of life, the difference values between preoperative and postoperative 1-year were evaluated; there was no significant difference between the EG with anti-reflux procedure and DTR groups. EG had higher incidence of esophageal reflux and similar nutritional outcomes and QOL compared with the double-tract reconstruction after laparoscopic proximal gastrectomy. Additional large-scale research is needed to evaluate the long-term functional outcomes of EG and the double-tract reconstruction. | Eom, Bang Wool; Park, Ji Yeon; Park, Ki Bum; Yoon, Hong Man; Kwon, Oh Kyoung; Ryu, Keun Won; Kim, Young-Woo | Natl Canc Ctr, Ctr Gastr Canc, Goyang, South Korea; Kyungpook Natl Univ, Sch Med, Dept Surg, Daegu, South Korea; Grad Sch Canc Sci & Policy, Dept Canc Control & Populat Hlth, Goyang, South Korea | Eom, Bang/K-4412-2016; Kim, Yuriy/ABD-7016-2020; Park, Ji Yeon/AAV-2471-2020 | 22984747200; 57196405216; 57220965452; 35735626600; 26536109900; 55667555300; 57215377843 | jybark990118@naver.com; | MEDICINE | MEDICINE | 0025-7974 | 1536-5964 | 100 | 15 | SCIE | MEDICINE, GENERAL & INTERNAL | 2021 | 1.817 | 71.2 | 1.84 | 2025-07-30 | 20 | 17 | double-tract reconstruction; esophagogastrostomy; proximal gastrectomy; quality of life; stomach neoplasm | EARLY GASTRIC-CANCER; DOUBLE-FLAP TECHNIQUE; FUNCTIONAL OUTCOMES; DEFICIENCY; MODULE | double-tract reconstruction; esophagogastrostomy; proximal gastrectomy; quality of life; stomach neoplasm | Aged; Esophagectomy; Female; Gastrectomy; Gastroesophageal Reflux; Humans; Incidence; Laparoscopy; Male; Middle Aged; Nutritional Status; Postoperative Complications; Postoperative Period; Quality of Life; Reconstructive Surgical Procedures; Retrospective Studies; Stomach Neoplasms; Treatment Outcome; adverse event; aged; comparative study; esophagus resection; female; gastrectomy; gastroesophageal reflux; human; incidence; laparoscopy; male; middle aged; nutritional status; pathophysiology; postoperative complication; postoperative period; procedures; quality of life; reconstructive surgery; retrospective study; stomach tumor; treatment outcome | English | 2021 | 2021-04-16 | 10.1097/md.0000000000025453 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Meeting Abstract | Development of a new risk stratification system for patients with newly diagnosed multiple myeloma using R-ISS and 18F-FDG PET/CT | Kim, Juhyung; Lee, Jung Min; Cho, Hee Jeong; Jung, Sung-Hoon; Shin, Ho-Jin; Mun, Yeung-Chul; Lee, Ho Sup; Min, Chang-Ki; Kim, Kihyun; Lee, Je-Jung; Moon, Joon Ho; Park, Sung-Soo | Kyungpook Natl Univ Hosp, Daegu, South Korea; Chonnam Natl Univ, Hwasun Hosp, Hwasun, South Korea; Pusan Natl Univ Hosp, Dept Internal Med, Busan, South Korea; Ewha Womans Univ, Sch Med, Seoul, South Korea; Kosin Univ, Gospel Hosp, Busan, South Korea; Seoul St Marys Hosp, Dept Hematol, Seoul, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Med,Div Hematol Oncol, Seoul, South Korea; Chonnam Natl Univ, Hwasun Hosp, Dept Hematol Oncol, Hwasun, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med,Div Hematol Oncol, Daegu, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Internal Med,Div Hematol, Seoul, South Korea | Kim, Kihyun/D-5175-2013; Kim, Jwa/AAH-9915-2021; Lee, Jung-Hye/F-6974-2013; KIM, JIN/I-6927-2019; Lee, Jung-Min/L-8227-2016 | CLINICAL LYMPHOMA MYELOMA & LEUKEMIA | CL LYMPH MYELOM LEUK | 2152-2650 | 2152-2669 | 21 | SCIE | HEMATOLOGY;ONCOLOGY | 2021 | 2.822 | 71.2 | 0 | English | 2021 | 2021-10 | 10.1016/s2152-2650(21)02147-9 | 바로가기 | 바로가기 | 바로가기 | ||||||||||||||
| ○ | ○ | Review | Does polydeoxyribonucleotide has an effect on patients with tendon or ligament pain? A PRISMA-compliant meta-analysis | Background: Pain in the tendons or ligaments is extremely common, accounting for 30% of the causes of visiting general practitioners. Polydeoxyribonucleotide (PDRN) is emerging as a new treatment for musculoskeletal pain. However, the effects of PDRN in patients with tendon or ligament pain are unclear. Therefore, this study aimed to determine the impact of PDRN in patients with tendon or ligament pain through a meta-analysis. Methods: Electronic literature search of PubMed, Embase, SCOPUS, and Cochrane Library databases of all articles on PDRN treatment for patients with tendon or ligament pain published in the English language from inception until January 31, 2020. The search identified 262 citations. Results: One randomized controlled trial and 3 retrospective observational studies were included. Pain due to tendon or ligament disorders showed significant improvement after PDRN injection (standardized mean difference [SMD] = -1.43, 95% confidence interval [CI] = -1.80 to -1.06, P < .00001). In the subanalysis of patients with rotator cuff tendinopathy, rotator cuff tendinopathy-induced pain significantly improved (SMD = -2.34, 95% CI = -3.61 to -1.07, P = .0003) after PDRN injection. However, there was no difference in shoulder pain and disability index score and strength of shoulder abduction in patients with rotator cuff tendinopathy (shoulder pain and disability index score, SMD = 1.16, 95% CI = -1.20 to 3.52, P = .34; strength of shoulder abduction, SMD = 0.42, 95% CI = -0.03 to 0.88, P = .07). Conclusion: Effective pain relief was achieved in patients with tendon or ligament disorders after PDRN injection. To more precisely determine this effect, a meta-analysis with a larger number of clinical trials is warranted. | Gwak, Dae-Won; Hwang, Jong-Moon; Kim, Ae Ryoung; Park, Donghwi | Kyungpook Natl Univ, Sch Med, Dept Rehabil Med, Daegu, South Korea; Univ Ulsan, Ulsan Univ Hosp, Dept Phys Med & Rehabil, Coll Med, 877 Bangeojinsunghwndo Ro, Ulsan 44033, South Korea | Park, Donghwi/GYQ-6185-2022 | 57212010177; 56367634000; 57196257330; 56606561400 | bdome@hanmail.net; | MEDICINE | MEDICINE | 0025-7974 | 1536-5964 | 100 | 19 | SCIE | MEDICINE, GENERAL & INTERNAL | 2021 | 1.817 | 71.2 | 0.15 | 2025-07-30 | 6 | 6 | ligamentopathy; musculoskeletal pain; polydeoxyribonucleotide; tendinopathy | TENDINOPATHY; ADENOSINE; INJECTION | ligamentopathy; musculoskeletal pain; polydeoxyribonucleotide; tendinopathy | Analgesics; Humans; Injections; Ligaments; Musculoskeletal Pain; Pain Measurement; Polydeoxyribonucleotides; Tendinopathy; Treatment Outcome; analgesic agent; polydeoxyribonucleotide; human; injection; ligament; meta analysis; musculoskeletal pain; pain measurement; tendinitis; treatment outcome | English | 2021 | 2021-05-14 | 10.1097/md.0000000000025792 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Review | Early critical cortical infarction by anti-angiotensin II type 1 receptor antibody A case report and literature review | Rationale: Anti-angiotensin II type 1 receptor antibodies (AT(1)R-Abs) have been demonstrated to increase the risk of antibody-mediated rejection. We report a case of AT(1)R-Ab mediated rejection which caused early critical cortical infarction. Patient concerns: A 52-year-old man with end-stage kidney disease underwent preemptive kidney transplantation (KT) from his wife. He had no immunologic risk except ABO incompatibility. Proper desensitization treatment were applied prior to KT. On postoperative day 1, he showed stable clinical course with adequate urine output, but there was no decrease in serum creatinine level and imaging studies showed hypoperfusion in the transplanted kidney. Diagnoses: Allograft biopsy revealed total cortical infarction with severe necrotizing vasculitis, but the medullary area was preserved. Serum AT(1)R-Ab concentration was elevated from 10.9 U/mL before KT to 19.1 U/mL on 7 days after KT. Interventions: He was treated with plasmapheresis, intravenous immunoglobulin, rituximab, high-dose methylprednisolone, and bortezomib. Outcomes: The treatment showed a partial response, and he was discharged with 7.3 mg/dL creatinine level. At 4 months, his creatinine plateaued at 5.5 mg/dL and AT(1)R-Ab decreased to 3.6 U/mL. Lessons: This case highlights the risk of early active antibody-mediated rejection by preformed AT(1)R-Ab, suggesting its ability to exhibit atypical histopathologic findings, such as total cortical infarction. | Lim, Jeong-Hoon; Han, Man-Hoon; Kim, Yong-Jin; Huh, Seung; Kim, Chan-Duck | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Pathol, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Surg, Daegu, South Korea | Kim, Yong-Jin/J-2745-2012; Lim, Jeong-Hoon/ABE-6003-2020 | 55360244300; 57194067936; 56150365500; 7101832929; 8558530700 | drcdkim@knu.ac.kr; | MEDICINE | MEDICINE | 0025-7974 | 1536-5964 | 100 | 21 | SCIE | MEDICINE, GENERAL & INTERNAL | 2021 | 1.817 | 71.2 | 0 | 2025-07-30 | 0 | 0 | angiotensin II type 1 receptor antibody; antibody-mediated rejection; cortical infarction; kidney transplantation | ANTIENDOTHELIAL CELL ANTIBODIES; NON-HLA ANTIBODIES; PRETRANSPLANT SENSITIZATION; RISK-FACTOR; GRAFT; REJECTION; TRANSPLANTATION | angiotensin II type 1 receptor antibody; antibody-mediated rejection; cortical infarction; kidney transplantation | Allografts; Female; Graft Rejection; Histocompatibility Testing; Humans; Immunologic Factors; Infarction; Isoantibodies; Kidney Cortex; Kidney Cortex Necrosis; Kidney Failure, Chronic; Kidney Transplantation; Living Donors; Male; Middle Aged; Plasmapheresis; Receptor, Angiotensin, Type 1; Spouses; Time Factors; alloantibody; angiotensin 1 receptor; immunologic factor; adverse event; allograft; blood; case report; chronic kidney failure; female; graft rejection; histocompatibility test; human; immunology; infarction; kidney cortex; kidney cortex necrosis; kidney transplantation; living donor; male; middle aged; pathology; plasmapheresis; spouse; time factor; vascularization | English | 2021 | 2021-05-28 | 10.1097/md.0000000000025958 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Effect of Nusinersen in a late onset spinal muscular atrophy patient for 14 months A case report | Rationale: Spinal muscular atrophy (SMA) is a genetic disorder caused by genetic defect of SMN1 gene. SMA was an untreatable disease until 2016, when Nusinersen an antisense oligonucleotide therapy was approved for treatment. We report the effect of Nusinersen in a late onset SMA for 14 months. Patient concerns: A 13-year-old boy who was diagnosed as SMA with progressive proximal limb weakness was treated with intrathecal injection of Nusinersen. Diagnosis: The patient had progressive proximal limb weakness after 2 years of age. The patient had elevated creatine kinase level and shoed neurogenic changes in the needle electromyography study. After genetic analysis, homozygous deletion in Exon 7 and 8 of SMN1 protein was found and he was diagnosed as late onset SMA. Interventions: Intrathecal Nusinersen was administered per protocol. Outcomes: After 14 months of treatment, the patient showed significant clinical improvement in the revised Hammersmith functional rating scale and 6-minute walk test. Lessons: Although there is limited data on the effect of Nusinersen in late onset SMA patients, our case adds on the effectiveness even in late onset SMA. More studies are needed to consolidate the effects and adverse events of Nusinersen in late onset SMA. | Park, Jin-Mo; Min, Yu-Sun; Park, Donghwi; Park, Jin-Sung | Dongguk Univ, Gyeongju Hosp, Coll Med, Dept Neurol, Gyeongju, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Rehabil, Daegu, South Korea; Univ Ulsan, Coll Med, Ulsan Univ Hosp, Dept Phys Med & Rehabil, Ulsan, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Neurol, Daegu, South Korea | Park, Donghwi/GYQ-6185-2022 | 55569003000; 48061349800; 56606561400; 44061744500 | neurojspark@gmail.com; | MEDICINE | MEDICINE | 0025-7974 | 1536-5964 | 100 | 1 | SCIE | MEDICINE, GENERAL & INTERNAL | 2021 | 1.817 | 71.2 | 0.34 | 2025-07-30 | 5 | 4 | 6-minute walk test; adverse event; Hammersmith rating scale; Nusinersen; spinal muscular atrophy | SHAM CONTROL | 6-minute walk test; adverse event; Hammersmith rating scale; Nusinersen; spinal muscular atrophy | Adolescent; Diagnosis, Differential; Humans; Magnetic Resonance Imaging; Male; Muscular Atrophy, Spinal; Oligonucleotides; nusinersen; oligonucleotide; adolescent; case report; diagnostic imaging; differential diagnosis; human; male; nuclear magnetic resonance imaging; spinal muscular atrophy | English | 2021 | 2021-01-08 | 10.1097/md.0000000000024236 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Efficacy and safety of the recombinant human growth hormone in short children born small for gestational age A randomized, multicentre, comparative phase III trial | Objective: Growth hormone (GH) treatment is known to be effective in increasing stature in children with a short stature born small for gestational age (SGA). This multicentre, randomized, open-label, comparative, phase III study aimed to evaluate the efficacy and safety of Growtropin-II (recombinant human GH) and to demonstrate that the growth-promoting effect of Growtropin-II is not inferior to that of Genotropin in children with SGA (NCT ID: NCT02770157). Methods: Seventy five children who met the inclusion criteria were randomized into 3 groups in a ratio of 2:2:1 (the study group [Growtropin-II, n = 30], control group [Genotropin, n = 30], and 26-week non-treatment group [n = 15]). The study and control groups received subcutaneous injections of Growtropin-II and Genotropin, respectively for 52 weeks, whereas the non-treatment group underwent a non-treatment observation period during weeks 0 to 26 and a dosing period during weeks 27 to 52 and additional dosing till week 78 only in re-consenting children. Results: No significant differences in demographic and baseline characteristics between the groups were observed. The mean +/- standard deviation change difference in annualized height velocity (aHV) (study group - control group) was 0.65 +/- 2.12 cm/year (95% confidence interval [CI], -0.53 to 1.83), whereas the lower limit for the 2-sided 95% CI was -0.53 cm/year. Regarding safety, treatment-emergent adverse events (TEAEs) occurred in 53.33% children in the study group and 43.33% children in the control group; the difference in the incidence of TEAEs between the 2 treatment groups was not statistically significant (P = .4383). A total of 17 serious adverse events (SAEs) occurred in 13.33% children in the treatment groups, and no significant difference in incidence between groups (P = .7065) was seen. Two cases of adverse drug reaction (ADR) occurred in 2 children (3.33%): 1 ADR (injection site swelling or pain) occurred in 1 child (3.33%) each in the study and control groups. Conclusions: This study demonstrates that the change in aHV from the baseline till 52 weeks with Growtropin-II treatment is non-inferior to that with Genotropin treatment in children with short stature born SGA. Growtropin-II is well-tolerated, and its safety profile is comparable with that of Genotropin over a 1-year course of treatment. | Kim, Su Jin; Kim, Min-Sun; Cho, Sung Yoon; Suh, Byung-Kyu; Ko, Cheol Woo; Lee, Kee-Hyoung; Yoo, Han-Wook; Shin, Choong Ho; Hwang, Jin Soon; Kim, Ho-Seong; Chung, Woo Yeong; Kim, Chan Jong; Han, Heon-Seok; Jin, Dong-Kyu | Inha Univ, Coll Med, Inha Univ Hosp, Dept Pediat, Incheon, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Pediat, 81 Irwon Ro, Seoul 06351, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Dept Pediat, Seoul, South Korea; Kyungpook Natl Univ Hosp, Dept Pediat, Daegu, South Korea; Korea Univ, Anam Hosp, Dept Pediat, Seoul, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Pediat,Med Genet Clin & Lab,Childrens Hosp, Seoul, South Korea; Seoul Natl Univ, Childrens Hosp, Dept Pediat, Seoul, South Korea; Ajou Univ Hosp, Dept Pediat, Suwon, South Korea; Yonsei Univ, Coll Med, Severance Hosp, Dept Pediat, Seoul, South Korea; Inje Univ, Busan Paik Hosp, Dept Pediat, Busan, South Korea; Chonnam Natl Univ Hosp, Dept Pediat, Gwangju, South Korea; Chungbuk Natl Univ Hosp, Dept Pediat, Cheongju, South Korea | Shin, Choong/J-5526-2012; Lee, Byung-Hyun/AAD-7977-2022; Kim, Seonghwan/AAZ-1679-2021; Saad, Khaled/G-9901-2012 | 57203773231; 58736569200; 57217829002; 23026105800; 7202596445; 8629768500; 7201373304; 8505197600; 35205334700; 37031208400; 8605959600; 55664409000; 35276984600; 55666965500; 55877227500 | jindk.jin@samsung.com; | MEDICINE | MEDICINE | 0025-7974 | 1536-5964 | 100 | 30 | SCIE | MEDICINE, GENERAL & INTERNAL | 2021 | 1.817 | 71.2 | 0.11 | 2025-07-30 | 1 | 2 | recombinant human growth hormone; short stature; small for gestational age | SHORT STATURE; TERM SMALL; LONG-TERM; DOUBLE-BLIND; GH TREATMENT; INFANTS; HEIGHT; BIRTH | recombinant human growth hormone; short stature; small for gestational age | Child; Child, Preschool; Female; Human Growth Hormone; Humans; Infant, Newborn; Infant, Small for Gestational Age; Male; Recombinant Proteins; human growth hormone; recombinant protein; child; clinical trial; comparative study; controlled study; female; human; male; multicenter study; newborn; phase 3 clinical trial; preschool child; randomized controlled trial; small for date infant | English | 2021 | 2021-07-30 | 10.1097/md.0000000000026711 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Efficacy of ganglion impar block on vulvodynia Case series and results of mid- and long-term follow-up | Rationale: Vulvodynia is a common chronic gynecological disease that affects approximately 16% of women, although it is rarely diagnosed. However, no known effective treatment exists. The etiology of vulvodynia is unknown and may be heterogeneous and multifactorial, so it is difficult-if not impossible-to improve this condition using 1 treatment method. Reports have shown that vulvodynia has an element of neuropathic pain. Although the role of the sympathetic nervous system in neuropathic pain is controversial, sympathetic nerve blocks have long been used to treat patients with chronic pain giving good results. A ganglion impar block (GIB), a sympathetic nerve block technique, may effectively manage pain and discomfort in patients with vulvodynia. Patient concerns: Four patients suffering from chronic vulvar pain for 6 months-10 years were referred by gynecologists. The gynecologists could not identify the cause of the chronic vulvar pain, and symptoms were not improving by conservative therapy with medication. Patients complained of various chronic vulvar pain or discomfort. The initial visual analog scale (VAS) scores were 8 or 9 out of 10, and Leeds assessment of neuropathic symptoms and signs pain scale score was more than 12 out of 24. The review of gynecological medical records confirmed whether they showed allodynia during the cotton swab test and hyperalgesia to pin-prick test. Diagnoses: All patients were diagnosed with vulvodynia. Interventions: All patients were treated with a GIB, once in 2 patients, 3 times in 1 patient, and 4 times (1 alcoholic neurolysis) in the other patient, under fluoroscopic guidance. Outcomes: After the procedures, the VAS score and the leeds assessment of neuropathic symptoms and signs (LANSS) pain scale score were decreased to less than 2 and 5, respectively, in all patients. Follow-up observations for 6 months-2 years revealed that 2 patients' symptoms entirely or nearly entirely improved and did not require further treatment. The pain of the remaining patients were well controlled with medications only. Lessons: GIB is a good treatment option for patients suffering from chronic pain and discomfort caused by vulvodynia. | Hong, Dae Gy; Hwang, Seong-Min; Park, Jun-Mo | Kyungpook Natl Univ, Sch Med, Dept Obstet & Gynecol, Daegu, South Korea; Kyungpook Natl Univ Hosp, Dept Anesthesiol & Pain Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Anesthesiol & Pain Med, Daegu, South Korea | 26656670100; 57224076487; 55967725100; 57219116205 | pjm4013@naver.com; | MEDICINE | MEDICINE | 0025-7974 | 1536-5964 | 100 | 30 | SCIE | MEDICINE, GENERAL & INTERNAL | 2021 | 1.817 | 71.2 | 1.03 | 2025-07-30 | 7 | 9 | ganglion impar block; sympathetic; vulvar pain; vulvodynia | DIAGNOSIS; PAIN; MANAGEMENT; RELIABILITY; ANATOMY | ganglion impar block; sympathetic; vulvar pain; vulvodynia | Adult; Aged; Analgesics; Female; Humans; Middle Aged; Nerve Block; Vulvodynia; analgesic agent; adult; aged; case report; female; human; middle aged; nerve block; procedures; vulvodynia | English | 2021 | 2021-07-30 | 10.1097/md.0000000000026799 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Inferior mesenteric plexus block under computed tomography guidance A case report | Rationale: Inferior mesenteric plexus block is indicated for left-sided lower abdominal pain. However, in patients with terminal cancer, severe abdominal pain can prevent the patient from maintaining the necessary posture during the procedure, and considerable anatomic deformation owing to extensive growth, invasion, and metastasis of the tumor in the abdominal cavity can make the procedure difficult. In these cases, performing the procedures under computed tomography (CT) guidance can ensure greater safety and accuracy. Patient concerns: A 63-year-old man was referred for severe left-sided lower abdominal pain. He was unable to lie prone owing to severe lower abdominal pain and right hip surgery performed 15 years ago. His visual analog scale score was 9 out of 10. Diagnoses: The patient had terminal pancreatic tail cancer. Compared with abdominal CT findings obtained 50 days ago, hepatic metastasis and peritoneal seeding were still present, infiltration to the tissues around the pancreas and retrogastric area was increased, and most of the abdominal aorta was encased. In addition, metastatic lymph nodes were identified in several areas on the left including the left para-aortic area. However, the lesion causing the pain could not be identified. Therefore, an inferior mesenteric plexus block was performed according to the patient's complaint. Interventions: Epidural patient-controlled analgesia was performed first. The patient's pain consequently reduced to a certain level, and the prone position became possible to some extent, so a CT-guided inferior mesenteric plexus block was performed 2 days later. Outcomes: After the CT-guided inferior mesenteric plexus block, it became possible to control the patient's pain with a fentanyl patch 75 mcg/hour only, and his visual analog scale score was reduced to 4. After 4 weeks, the patient died without complaints of severe pain as before. Lessons: CT-guided inferior mesenteric plexus block can be performed in patients with left-sided lower abdominal pain, enabling a safer and more accurate procedure especially in patients with terminal cancer who are unable to lie prone owing to severe lower abdominal pain or with considerable anatomic deformation due to extensive growth, invasion, and metastasis of the tumor in the abdominal cavity. | Park, Jun-Mo; Hwang, Seong-Min | Kyungpook Natl Univ, Sch Med, Dept Anesthesiol & Pain Med, Daegu, South Korea; Kyungpook Natl Univ Hosp, Dept Anesthesiol & Pain Med, Daegu, South Korea | 55967725100; 57224076487; 57219116205 | pjm4013@naver.com; | MEDICINE | MEDICINE | 0025-7974 | 1536-5964 | 100 | 19 | SCIE | MEDICINE, GENERAL & INTERNAL | 2021 | 1.817 | 71.2 | 0 | 2025-07-30 | 0 | 0 | abdominal pain; autonomic nerve block; cancer; inferior mesenteric plexus; neurolysis; sympathectomy | PANCREATIC-CANCER; PAIN; ANATOMY; NEUROLYSIS | abdominal pain; autonomic nerve block; cancer; inferior mesenteric plexus; neurolysis; sympathectomy | Abdominal Pain; Autonomic Nerve Block; Cancer Pain; Celiac Plexus; Humans; Lymphatic Metastasis; Male; Middle Aged; Pancreatic Neoplasms; Tomography, X-Ray Computed; abdominal pain; cancer pain; case report; celiac plexus; complication; human; lymph node metastasis; male; middle aged; nerve block; pancreas tumor; procedures; x-ray computed tomography | English | 2021 | 2021-05-14 | 10.1097/md.0000000000025866 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Intraoperative development of pulmonary thromboembolism in a bedridden patient owing to a pelvic bone fracture with negative preoperative computed tomography pulmonary angiographic findings A case report | Rationale: Pulmonary thromboembolism (PTE) is a potentially life-threatening condition with high morbidity and mortality, and computed tomographic pulmonary angiography (CTPA) is an important diagnostic tool for patients in whom PTE is suspected; however, intraoperative PTE is very difficult to diagnose and often has a rapid clinical course. We experienced a case of intraoperative PTE with persistent tachycardia refractory to conventional treatments despite negative preoperative CTPA findings. Patient concerns: A 53-year-old man with a pelvic bone fracture who had been on bed rest for 10 days underwent open reduction and internal fixation under general anesthesia. He remained tachycardic (heart rate of 120 beats/min) despite treatments with fluid resuscitation, analgesics, and beta-blockers. Diagnoses: Preoperative CTPA, computed tomography (CT) venography, and transthoracic echocardiography showed no signs of deep vein thrombosis and PTE. However, the levels of D-dimer were elevated. After the start of the surgery, tachycardia (heart rate between 100 and 110 beats/min) could not be treated with fluid resuscitation. Systolic blood pressure was maintained between 90 and 100 mm Hg using continuous infusion of phenylephrine. Ninety minutes after the surgery, systolic and diastolic blood pressures suddenly dropped from 100/60 to 30/15 mm Hg with a decrease in end-tidal carbon dioxide concentration from 29 to 13 mm Hg and development of atrial fibrillation. Arterial blood gas analysis revealed hypercapnia. Under the suspicion of PTE, cardiopulmonary resuscitation (CPR) was immediately initiated. Three CPR cycles raised the blood pressure back to 90/50 mm Hg with sinus tachycardia (115 beats/min). Transesophageal echocardiography showed right ventricular dysfunction and paradoxical septal motion. However, emboli were not found. Postoperative chest CT revealed massive PTE in both pulmonary arteries. Interventions: Immediately, surgical embolectomy was performed uneventfully. Outcomes: The patient was discharged from the hospital 1 month later without any complications. Lessons: The patient with moderate risk for PTE (heart rate > 95 beats/min and immobilization, surgery under general anesthesia, and lower limb fracture within 1 month) should be closely monitored and managed intraoperatively even if preoperative CTPA findings are negative. The development of PTE needs to be expected if tachycardia is refractory to conventional treatments. | Kim, Jong Hae; Lim, Hyungseop; Kim, Hyun Mi; Lim, Jung A. | Daegu Catholic Univ, Sch Med, Dept Anesthesiol & Pain Med, 33 Duryugongwon Ro,17 Gil, Daegu 42472, South Korea; Kyungpook Natl Univ, Sch Med, Dept Obstet & Gynecol, Daegu, South Korea | Kim, JongHae/HGC-1554-2022 | 57865562800; 57226616338; 57219838830; 57212528924 | definitebud@naver.com; | MEDICINE | MEDICINE | 0025-7974 | 1536-5964 | 100 | 29 | SCIE | MEDICINE, GENERAL & INTERNAL | 2021 | 1.817 | 71.2 | 0 | 2025-07-30 | 0 | 0 | computed tomographic pulmonary angiography; pelvic bone fracture; pulmonary thromboembolism; tachycardia | TRANSESOPHAGEAL ECHOCARDIOGRAPHY; EMBOLISM; DIAGNOSIS; THROMBOSIS; UTILITY | Computed tomographic pulmonary angiography; Pelvic bone fracture; Pulmonary thromboembolism; Tachycardia | Bedridden Persons; Computed Tomography Angiography; Diagnosis, Differential; Fractures, Bone; Humans; Intraoperative Complications; Male; Middle Aged; Pelvis; Pulmonary Embolism; analgesic agent; beta adrenergic receptor blocking agent; bisoprolol; D dimer; epinephrine; fresh frozen plasma; haloperidol; Hartmann solution; hydroxyethyl starch; noradrenalin; phenylephrine; propofol; quetiapine; remifentanil; rocuronium; thiamine; warfarin; adult; alcoholic delirium; anesthesia induction; anticoagulant therapy; arterial gas; Article; atrial fibrillation; bed rest; bedridden patient; bispectral index; breathing rate; cardiopulmonary bypass; case report; clinical article; computed tomographic venography; computed tomography pulmonary angiography; continuous infusion; dehydration; diastolic blood pressure; end tidal carbon dioxide tension; endotracheal intubation; erythrocyte transfusion; fluid resuscitation; general anesthesia; heart right ventricle failure; heart right ventricle function; hospital discharge; human; hypercapnia; iliopsoas hematoma; lung embolism; male; middle aged; open reduction (procedure); osteosynthesis; oxygen saturation; pain; pelvis fracture; preoperative evaluation; pulmonary artery; radiodiagnosis; resuscitation; sinus tachycardia; surgical embolectomy; systolic blood pressure; tachycardia; tidal volume; transesophageal echocardiography; transthoracic echocardiography; urine volume; bedridden patient; computed tomographic angiography; diagnostic imaging; differential diagnosis; fracture; injury; lung embolism; pelvis; peroperative complication | English | 2021 | 2021-07-23 | 10.1097/md.0000000000026658 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Long interspersed nuclear element-1 hypomethylation is associated with poor outcomes via the activation of ST18 in human hepatocellular carcinoma | The level of long interspersed nuclear element-1 (LINE-1) methylation, representing the global deoxyribonucleic acid methylation level, could contribute to the prognosis of cancer via the activation of oncogenes. This study was performed to evaluate the prognostic implications of LINE-1 hypomethylation in patients with hepatocellular carcinoma (HCC) and the possible mechanisms related to oncogene activation. Seventy-seven HCC patients between October 2014 and September 2015 were enrolled in this prospective study. Quantitative pyrosequencing was performed to assess the LINE-1 methylation level of HCC and matched non-HCC tissue samples. The expression of suppression of tumorigenicity 18 was measured by immunohistochemistry and its correlation with LINE-1 methylation levels was examined. LINE-1 was significantly hypomethylated in the HCC tissue compared with the matched nontumor tissue (64.0 +/- 11.6% vs 75.6 +/- 4.0%, P < .001). LINE-1 hypomethylation was an independent risk factor for overall survival (hazard ratio = 27.291, P = .032) and disease progression (hazard ratio = 5.298, P = .005). The expression of suppression of tumorigenicity 18 was higher in the hypomethylated LINE-1 HCC tissue than the hypermethylated LINE-1 tumor tissue (P = .030). LINE-1 hypomethylation may serve as a potential prognostic marker for patients with HCC. | Lee, Yu Rim; Kim, Gyeonghwa; Lee, Hye Won; Tak, Won Young; Park, Soo Young; Jang, Se Young; Kweon, Young Oh; Park, Jung Gil; Han, Young Seok; Chun, Jae Min; Han, Ja Ryung; Hur, Keun | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Cell & Matrix Res Inst, Dept Biochem & Cell Biol, Daegu, South Korea; Keimyung Univ, Sch Med, Dept Pathol, Daegu, South Korea; Yeungnam Univ, Coll Med, Dept Internal Med, Gyongsan, Gyeongsangbuk D, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Surg, Daegu, South Korea | ; Kim, Gyeonghwa/AAQ-6424-2021; Park, Jung/AAK-5167-2020; Hur, Keun/G-9513-2011 | 57194094753; 57195957884; 57907713300; 7004074582; 57191674344; 57202881977; 7004694832; 57216816399; 7404096216; 24773178000; 57214671308; 8861888000 | KeunHur@knu.ac.kr; | MEDICINE | MEDICINE | 0025-7974 | 1536-5964 | 100 | 16 | SCIE | MEDICINE, GENERAL & INTERNAL | 2021 | 1.817 | 71.2 | 0.23 | 2025-07-30 | 2 | 2 | hepatocellular carcinoma; long interspersed nuclear element-1; methylation; prognosis; suppression of tumorigenicity 18 | LINE-1 HYPOMETHYLATION; CANCER; METHYLATION; PROGNOSIS; LIVER; RETROTRANSPOSITION; PATHOGENESIS; EPIGENETICS; TUMORS; GENES | hepatocellular carcinoma; long interspersed nuclear element-1; methylation; prognosis; suppression of tumorigenicity 18 | Biomarkers, Tumor; Biopsy; Carcinogenesis; Carcinoma, Hepatocellular; Disease Progression; DNA Methylation; Female; Humans; Immunohistochemistry; Liver; Liver Neoplasms; Long Interspersed Nucleotide Elements; Male; Middle Aged; Oncogenes; Prognosis; Proportional Hazards Models; Prospective Studies; Repressor Proteins; repressor protein; ST18 protein, human; tumor marker; biopsy; carcinogenesis; disease exacerbation; DNA methylation; female; genetics; human; immunohistochemistry; liver; liver cell carcinoma; liver tumor; long interspersed nuclear element; male; metabolism; middle aged; oncogene; prognosis; proportional hazards model; prospective study | English | 2021 | 2021-04-23 | 10.1097/md.0000000000025552 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | MicroRNA-496 inhibits triple negative breast cancer cell proliferation by targeting Del-1 | Del-1 has been linked to the pathogenesis of various cancers, including breast cancer. However, the regulation of Del-1 expression remains unclear. We previously reported the interaction between microRNA-137 (miR-137) and the Del-1 gene. In this study, we investigated miR-496 and miR-137 as regulators of Del-1 expression in triple negative breast cancer (TNBC). Del-1 mRNA and miR-496 were measured by quantitative PCR in breast cancer cells (MDA-MB-231, MCF7, SK-BR3, and T-47D) and tissues from 30 patients with TNBC. The effects of miR-496 on cell proliferation, migration, and invasion were determined with MTT, wound healing, and Matrigel transwell assays, respectively. In MDA-MB-231 cells, miR-496 levels were remarkably low and Del-1 mRNA levels were higher than in other breast cancer cell lines. Luciferase reporter assays revealed that miR-496 binds the 3 '-UTR of Del-1 and Del-1 expression is downregulated by miR-496 mimics. Furthermore, miR-496 inhibited the proliferation, migration, and invasion of MDA-MB-231 cells. The effects of miR-496 on cell proliferation were additive with those of miR-137, another miRNA that regulates Del-1 expression. Moreover, in the 30 TNBC specimens, miR-496 was downregulated (P < .005) and the levels of Del-1 in the plasma were significantly elevated as compared with in normal controls (P = .0142). The Cancer Genome Atlas (TCGA) data showed the correlation of miR-496 expression with better overall survival in patients with early TNBC. In in silico and in vitro analyses, we showed that Del-1 is a target of miR-496 in TNBC and thereby affects cancer progression. Our findings suggest that miR-496 and miR-137 additively target Del-1 and act as modulating factors in TNBC. They are potentially new biomarkers for patients with TNBC. | Lee, Soo Jung; Jeong, Jae-Hwan; Lee, Jeeyeon; Park, Ho Yong; Jung, Jin Hyang; Kang, Jieun; Kim, Eun Ae; Park, Nora Jee-Young; Park, Ji-Young; Lee, In Hee; Chae, Yee Soo | Kyungpook Natl Univ, Kyungpook Natl Univ Chilgok Hosp, Dept Oncol Hematol, Sch Med, Daegu, South Korea; Mmonitor Inc, 62 Seongseogongdan Ro 11gil, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Chilgok Hosp, Breast & Thyroid Surg, Daegu, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, Daegu, South Korea; Kyungpook Natl Univ, Exosome Convergence Res Ctr, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Chilgok Hosp, Sch Med, Pathol, Daegu, South Korea | PARK, JUN-YOUNG/P-5981-2015; Park, Young-Bae/J-5490-2012 | 57203597252; 59824768800; 37079213100; 56564377200; 57209310173; 57212252058; 55241586600; 57226185359; 57210160197; 57191881516; 57190793908 | yschae@knu.ac.kr; | MEDICINE | MEDICINE | 0025-7974 | 1536-5964 | 100 | 14 | SCIE | MEDICINE, GENERAL & INTERNAL | 2021 | 1.817 | 71.2 | 1.38 | 2025-07-30 | 11 | 12 | breast cancer; cancer biomarker; microRNA | DEVELOPMENTAL ENDOTHELIAL LOCUS-1; EXTRACELLULAR VESICLES; IDENTIFICATION; EXPRESSION; GROWTH; LINES; TRANSCRIPTION; BIOMARKER | breast cancer; cancer biomarker; microRNA | Calcium-Binding Proteins; Cell Adhesion Molecules; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Humans; MicroRNAs; Neoplasm Invasiveness; Real-Time Polymerase Chain Reaction; Triple Negative Breast Neoplasms; calcium binding protein; cell adhesion molecule; EDIL3 protein, human; microRNA; MIRN137 microRNA, human; MIRN496 microRNA, human; cell proliferation; down regulation; female; gene expression regulation; genetics; human; metabolism; pathology; real time polymerase chain reaction; triple negative breast cancer; tumor cell line; tumor invasion | English | 2021 | 2021-04-09 | 10.1097/md.0000000000025270 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | National level data analysis of facial lacerations in Korea using the National Health Insurance Service (NHIS) database | No national epidemiological investigations have been conducted recently regarding facial lacerations. The study was performed using the data of 3,634,229 people during the 5-year period from 2014 to 2018 archived by the National Health Information Database (NHID) of the Health Insurance Review and Assessment Service. Preschool and children under 10 years old accounted for about one-third of patients. Facial lacerations were concentrated in the "T-shaped" area, which comprised forehead, nose, lips, and the perioral area. The male to female ratio for all study subjects was 2.16:1. Age and gender are significantly related with each other (P < .001). Mean hospital stays decreased, and numbers of outpatient department visits per patient were highest for hospitals and lowest for health agencies. Over the study period, hospital costs per patient in tertiary and general hospitals increased gradually. Preschool and school-aged children are vulnerable to trauma. Male patients outnumbered female patients by a factor of more than 2. The "T-shaped'" area around forehead is vulnerable to injury. Total cost of medical care benefits per patient in tertiary hospitals was about 7 times on average than in health agencies. Regarding functional, behavioral, and aesthetic outcomes, more attention should be paid to epidemiologic data and hospital costs for facial lacerations. | Mo, Young Woong; Cho, Gyo-Young; Mo, Young Taek; Lee, Dong Lark | Dongguk Univ, Dept Plast & Reconstruct Surg, Grad Sch Med, 30,Pildong Ro 1 Gil, Seoul, South Korea; Dongguk Univ, Coll Med, Dept Plast & Reconstruct Surg, 87 Dongdae Ro, Gyeongju 38067, South Korea; Kyungpook Natl Univ, Dept Stat, 80 Daehakro, Bukgu, Daegu, South Korea; Incheon Natl Quarantine Stn, 365 Seohae Daero, Incheon, South Korea | 57215526629; 14043110800; 57222366923; 56495745900; 59067821700 | drleedr@gmail.com; | MEDICINE | MEDICINE | 0025-7974 | 1536-5964 | 100 | 9 | SCIE | MEDICINE, GENERAL & INTERNAL | 2021 | 1.817 | 71.2 | 0.23 | 2025-07-30 | 1 | 2 | data analyses; epidemiology; face; lacerations; wounds and injuries | data analyses; epidemiology; face; lacerations; wounds and injuries | Adolescent; Adult; Age Distribution; Ambulatory Care; Child; Child, Preschool; Databases, Factual; Facial Injuries; Female; Hospital Costs; Hospitals; Humans; Lacerations; Length of Stay; Male; National Health Programs; Republic of Korea; Sex Distribution; Young Adult; adolescent; adult; age distribution; ambulatory care; child; economics; face injury; factual database; female; hospital; hospital cost; human; laceration; length of stay; male; preschool child; public health; sex ratio; South Korea; young adult | English | 2021 | 2021-03-05 | 10.1097/md.0000000000024163 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Meeting Abstract | Real-world toxicity and efficacy of ixazomib, lenalidomide and dexamethasone in Asian RRMM patients supported by the patient assistance program | Lee, Ji Hyun; Kim, Sung-Hyun; Moon, Joon Ho; Min, Chang-Ki; Lee, Je-Jung; Shin, Ho-Jin; Jo, Jae-Cheol; Kim, Kihyun | Dong A Univ, Coll Med, Busan, South Korea; Dong A Univ, Coll Med, Dept Internal Med, Busan, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Dept Internal Med, Div Hematol Oncol,Sch Med, Daegu, South Korea; Seoul St Marys Hosp, Dept Hematol, Seoul, South Korea; Chonnam Natl Univ, Hwasun Hosp, Dept Hematol Oncol, Hwasun, South Korea; Pusan Natl Univ Hosp, Dept Internal Med, Busan, South Korea; Univ Ulsan, Dept Internal Med, Ulsan Univ Hosp, Coll Med, Ulsan, South Korea; Sungkyunkwan Univ, Div Hematol Oncol, Dept Med, Samsung Med Ctr,Sch Med, Seoul, South Korea | Lee, Jung-Hye/F-6974-2013; Jo, Jae-Cheol/CAE-9453-2022; Kim, Kihyun/D-5175-2013; KIM, JIN/I-6927-2019 | CLINICAL LYMPHOMA MYELOMA & LEUKEMIA | CL LYMPH MYELOM LEUK | 2152-2650 | 2152-2669 | 21 | SCIE | HEMATOLOGY;ONCOLOGY | 2021 | 2.822 | 71.2 | 0 | English | 2021 | 2021-10 | 10.1016/s2152-2650(21)02326-0 | 바로가기 | 바로가기 | 바로가기 |
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