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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Efficacy of combination therapy with pentosan polysulfate sodium and adipose tissue-derived stem cells for the management of interstitial cystitis in a rat model | We evaluated the synergistic effects of pentosan polysulfate sodium (PPS) and mesenchymal stem cells (MSCs) in an interstitial cystitis (IC) rat model. After generation of the IC rat model, the rats were divided into 4 groups according to the treatment they received: phosphate-buffered saline injection into bladder submucosa, daily oral PPS feeding, MSC injection into bladder submucosa, or MSC injection into bladder submucosa with daily oral PPS feeding. After treatment, conscious cystometry and pain scale measurement were performed and their bladders were obtained for histological and proinflammatory-related gene expression analysis. On cystometric analysis, all treatment groups showed significantly increased intercontraction intervals and lower pain scores compared to those of the control group. Histological analysis revealed regenerated urothelium, less fibrosis, and decreased mast cell infiltration in all treatment groups compared to the control group. Significantly lower expression of TNF-alpha, IFN-gamma, MCP, IL-6, TLR2, and TLR11 was observed in the PPS with MSC group compared to the other groups. Combination therapy with PPS and MSCs showed histological and functional effects in an IC rat model, including synergistic effects leading to increased intercontraction interval and decreased inflammatory reactions. | Kim, Bum Soo; Chun, So Young; Lee, Eun Hye; Chung, Jae-Wook; Lee, Jun Nyung; Ha, Yun-Sok; Choi, Jae Young; Song, Phil Hyun; Kwon, Tae Gyun; Han, Man-Hoon; Kim, Dae Hwan; Yoo, Eun Sang | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Urol, Daegu, South Korea; Kyungpook Natl Univ Hosp, Biomed Res Inst, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Urol, Daegu, South Korea; Yeungnam Univ, Dept Urol, Coll Med, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Pathol, Daegu, South Korea; Yeungnam Univ Hosp, Dept Lab Anim Res Support Team, Daegu, South Korea | ; Kim, Young-Bo/AAR-8052-2021; Kim, Soo-Yeon/ADR-9663-2022; Lee, Eun-Hye/KDN-5679-2024 | 57202817150; 8688166900; 57189661699; 35204798500; 16301364600; 35487226400; 55722526800; 8644562400; 15073765400; 57194067936; 55897992900; 7006609239 | uroyoo@knu.ac.kr; | STEM CELL RESEARCH | STEM CELL RES | 1873-5061 | 1876-7753 | 45 | SCIE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY;CELL & TISSUE ENGINEERING;CELL BIOLOGY | 2020 | 2.02 | 82.1 | 0.98 | 2025-06-25 | 16 | 15 | Interstitial cystitis; Rats; Stem cells; Pentosan polysulfate sodium | Interstitial cystitis; Pentosan polysulfate sodium; Rats; Stem cells | gamma interferon; interleukin 17; interleukin 1alpha; interleukin 1beta; interleukin 6; monocyte chemotactic protein; pentosan polysulfate; toll like receptor 11; toll like receptor 2; toll like receptor 4; toll like receptor 5; tumor necrosis factor; adipose derived stem cell; animal experiment; animal model; animal tissue; Article; bladder mucosa; cell infiltration; controlled study; cystometry; drug efficacy; female; gene expression; histopathology; inflammation; interstitial cystitis; mast cell; mesenchymal stem cell; nonhuman; pain assessment; priority journal; protein expression; rat; synergistic effect; urothelium | English | 2020 | 2020-05 | 10.1016/j.scr.2020.101801 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | In vitro characterization of glycyrol metabolites in human liver microsomes using HR-resolution MS spectrometer coupled with tandem mass spectrometry | 1. Glycyrol is a coumestan derivative that is isolated from roots of Glycyrrhiza uralensis. Glycyrol exhibits several biological effects, including anti-oxidative and anti-inflammatory effects. 2. Herein, we characterized glycyrol metabolism by cytochrome P450 enzymes (CYPs) and UDP-glucuronosyltransferases (UGTs) using human liver microsomes (HLM), human liver cytosol, human intestinal microsomes, or human recombinant cDNA-expressed CYPs and UGTs. The analysis was conducted using high resolution mass spectroscopy (HR-MS) on a Q Exactive(TM) HF Hybride Quadrupole-Orbitrap mass spectrometer. 3. NADPH-supplemented HLM generated six glycyrol metabolites (M1-M6) via hydroxylation, oxidation, and hydration; both NADPH- and UDPGA-supplemented liver microsomes generated three glucuronides (M7-M9). Reaction phenotyping revealed that CYP1A2 is the primary enzyme responsible for phase I metabolism, with minor involvement of the CYP3A4/5, CYP2D6, and CYP2E1 enzymes. Glucuronidation of glycyrol was primarily mediated by UGT1A1, UGT1A3, UGT1A9, and UGT2B7. 4. In conclusion, glycyrol undergoes the efficient metabolic hydroxylation and glucuronidation reactions in human liver microsomes, which are predominantly catalyzed by CYP1A2, UGT1A1/3/9, and UGT2B7. | Kim, Younah; Shrestha, Riya; Kim, Sunjoo; Kim, Jeong Ah; Lee, Jaeick; Jeong, Tae Cheon; Kim, Ju-Hyun; Lee, Sangkyu | Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, Daegu, South Korea; Catholic Univ Korea, Coll Pharm, Plus Team Creat Leader Program Pharmac Based BK21, Bucheon, South Korea; Catholic Univ Korea, Coll Pharm, Integrated Res Inst Pharmaceut Sci, Bucheon, South Korea; Korea Inst Sci & Technol, Doping Control Ctr, Seoul, South Korea; Yeungnam Univ, Coll Pharm, Gyongsan 38541, South Korea | ; Shrestha, Riya/JCE-7436-2023 | 57211893872; 57193350367; 57051715600; 24722570900; 7601483869; 7102759745; 55720031300; 57209046767 | jhkim@yu.ac.kr;sangkyu@knu.ac.kr; | XENOBIOTICA | XENOBIOTICA | 0049-8254 | 1366-5928 | 50 | 4 | SCIE | PHARMACOLOGY & PHARMACY;TOXICOLOGY | 2020 | 1.908 | 82.1 | 0.53 | 2025-06-25 | 9 | 9 | Glycyrol; metabolite; CYP450; UGT; human liver microsomes | GLYCYRRHIZA-URALENSIS; DRUG-METABOLISM; IDENTIFICATION; INHIBITION; APOPTOSIS; LICORICE | CYP450; Glycyrol; human liver microsomes; metabolite; UGT | Cytochrome P-450 CYP1A2; Flavonoids; Glucuronides; Glucuronosyltransferase; Humans; Microsomes; Microsomes, Liver; Tandem Mass Spectrometry; cytochrome P450 1A2; flavonoid; glucuronide; glucuronosyltransferase; glycyrol; UDP-glucuronosyltransferase 1A9; human; liver microsome; metabolism; microsome; tandem mass spectrometry | English | 2020 | 2020-04-02 | 10.1080/00498254.2019.1636418 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Influence of Extraoral Polishing of the Crown-Abutment Interface on the Marginal Fit of Screw- and Cement-Retained Prostheses: A Clinical Pilot Study | Purpose: To assess the effect of extraoral polishing of the crown-abutment interface on the marginal fit of implant-supported screw- and cement-retained prostheses (SCRPs). Materials and Methods: In 31 patients, the marginal gap of an SCRP was measured using a stereomicroscope before and after polishing of the crown-abutment interface, and the paired data were compared. Results: The marginal gap was significantly decreased after surface polishing regardless of the prosthesis material (P < .001). Conclusion: Extraoral polishing of the crown-abutment interface could improve the marginal fit of SCRPs. | Kim, Mijoo; Lee, Du-Hyeong | Kyungpook Natl Univ, Sch Dent, Inst Translat Res Dent, Dept Prosthodont, 2175 Dalgubeoldae Ro, Daegu 41940, South Korea | 59806068600; 35770948000 | deweylee@knu.ac.kr;deweyiee@knu.ac.kr; | INTERNATIONAL JOURNAL OF PROSTHODONTICS | INT J PROSTHODONT | 0893-2174 | 1942-4426 | 33 | 6 | SCIE | DENTISTRY, ORAL SURGERY & MEDICINE | 2020 | 1.681 | 82.1 | 0 | 2025-06-25 | 0 | 0 | ACCURACY; CAD/CAM | Bone Screws; Cementation; Crowns; Dental Prosthesis, Implant-Supported; Humans; Pilot Projects; bone screw; cementation; human; implant-supported denture; pilot study; tooth crown | English | 2020 | 2020 (NOV-DEC) | 10.11607/ijp.6971 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Feasibility of the Inner-Side-Out Use of the LC-DCP for Periprosthetic Femoral Fracture in Total Hip Arthroplasty | Background The optimal technique for plate fixation to treat type B and C periprosthetic femoral fractures (PFFs) is unclear. The purpose of this study is to evaluate the radiographic results of inner-side-out limited contact dynamic compression plate (LC-DCP) to treat PFFs during or after total hip arthroplasty (THA). Methods This retrospective study comprised of four men and six women with an average age of 64.7 years who underwent open reduction and internal fixation with an inner-side-out LC-DCP technique to treat PFFs; the reduction was maintained preliminary with the use of contoured plate and cables, and the grooves on the undersurface of LC-DCP for limited contact was used to hold and prevent the cables from slippage during tightening the cables. There were five intraoperative and five postoperative PFFs after THA. According to the Vancouver classification, the intraoperative PFFs included type B2 in two, B3 in one and C3 in two patients while postoperative PFFs were categorized into type B1 in one, type B2 in two and type C in two patients. The mean follow-up duration was 5.9 years (range 1-10.4). We evaluated radiographic union and complications after index operation. Results All patients demonstrated radiographic bone union at an average follow-up duration of 4.4 months (range 3-8). Two patients showed stem subsidence after revision THA and one patient demonstrated a subsequent peri-implant fracture around the distal end of plate after union of the initial PPF; one patient underwent re-revision THA for stem loosening while another patient went through refixation for the peri-implant fracture. There was no nonunion, infection, nerve injury, or dislocation. Conclusion The inner-side-out LC-DCP technique showed satisfactory radiographic outcome. In certain situations where locking plates are not available, this technique might be a useful alternative for treating type B and C PFFs. | Won, Heejae; Kim, Jun-Young; Baek, Seung-Hoon; Hong, Wonki; Yoon, Jee-Wook; Kim, Shin-Yoon | Kyungpook Natl Univ Hosp, Dept Orthoped Surg, 130 Dongdeok Ro, Daegu 41944, South Korea; Daegu Catholic Univ Hosp, Dept Orthoped Surg, 33 Duryugongwon Ro 17 Gil, Daegu 42472, South Korea; Kyungpook Natl Univ, Sch Med, Dept Orthoped Surg, 130 Dongdeok Ro, Daegu 41944, South Korea | Kim, Soo/J-5411-2012 | 57209207044; 57201935381; 56232924900; 57218322356; 57188967905; 26663842900 | hj8403@gmail.com;drjunyoung@cu.ac.kr;insideme@para.com;towonkihong@gmail.com;leo831114@gmail.com;syukim@knu.ac.kr; | INDIAN JOURNAL OF ORTHOPAEDICS | INDIAN J ORTHOP | 0019-5413 | 1998-3727 | 54 | 6 | SCIE | ORTHOPEDICS | 2020 | 1.251 | 82.3 | 0.12 | 2025-06-25 | 1 | 1 | Inner-side-out; Limited contact dynamic compression plate; Periprosthetic femoral fracture; Total hip arthroplasty | LOCKING-PLATE OSTEOSYNTHESIS; DYNAMIC COMPRESSION PLATES; INTERNAL-FIXATION; FEMUR FRACTURES | Inner-side-out; Limited contact dynamic compression plate; Periprosthetic femoral fracture; Total hip arthroplasty | English | 2020 | 2020-11 | 10.1007/s43465-020-00200-9 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Editorial Material | Fatal Metronidazole-induced Encephalopathy | Hwang, Jaechun; Eun, Mi-Yeon | Kyungpook Natl Univ, Sch Med, Dept Neurol, Chilgok Hosp, 807 Hoguk Ro, Daegu 41404, South Korea | Eun, Mi-Yeon/AAV-2877-2021 | 54980345300; 36463396500 | eunmiyn@gmail.com; | NEUROLOGY INDIA | NEUROL INDIA | 0028-3886 | 1998-4022 | 68 | 2 | SCIE | NEUROSCIENCES | 2020 | 2.117 | 82.6 | 0 | 2025-06-25 | 1 | 1 | metronidazole; acquired immune deficiency syndrome; adult; anus cancer; brain disease; case report; clinical article; conservative treatment; corpus callosum; death; dentate nucleus; diffusion weighted imaging; disorientation; drug fatality; frontal cortex; human; immunocompromised patient; infection; male; medulla oblongata; mesencephalon; Note; pons; putamen; slurred speech; treatment duration; unconsciousness; white matter | English | 2020 | 2020 (MAR-APR) | 10.4103/0028-3886.284372 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Editorial Material | Linear Trigeminal Pontine Lesion in Multiple Sclerosis-related Trigeminal Neuropathy | Seok, Hung; Eun, Mi-Yeon | Keimyung Univ, Sch Med, Dongsan Med Ctr, Dept Neurol, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Neurol, 807 Hoguk Ro, Daegu 41404, South Korea | Eun, Mi-Yeon/AAV-2877-2021; Seok, Hung Youl/HZI-4365-2023 | 24472118000; 36463396500 | eunmiyn@gmail.com; | NEUROLOGY INDIA | NEUROL INDIA | 0028-3886 | 1998-4022 | 68 | 6 | SCIE | NEUROSCIENCES | 2020 | 2.117 | 82.6 | 0.58 | 2025-06-25 | 4 | 4 | INVOLVEMENT | Humans; Magnetic Resonance Imaging; Multiple Sclerosis; Pons; Trigeminal Nerve; Trigeminal Nerve Diseases; Trigeminal Neuralgia; interferon beta serine; methylprednisolone; adult; case report; clinical article; clinical examination; hospital admission; human; male; multiple sclerosis; myelitis; nerve lesion; Note; nuclear magnetic resonance imaging; paresthesia; trigeminal nerve; trigeminus neuralgia; complication; diagnostic imaging; multiple sclerosis; pons; trigeminal nerve; trigeminal nerve disease; trigeminus neuralgia | English | 2020 | 2020 (NOV-DEC) | 10.4103/0028-3886.304117 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | A Retrieved Sparganum of Spirometra erinaceieuropaei from a Korean Man during Mechanical Thrombectomy | Human sparganosis is a zoonotic disease caused by infection and migration of the plerocercoid of Spirometra spp. Although sparganosis were reported from most parts of the body, the sparganum parasitizing inside cerebral artery is remarkably uncommon. We report a case of cerebral intravascular sparganosis in an elderly patient with acute ischemic stroke who was diagnosed by retrieving sparganum during mechanical thrombectomy. Finally, the parasites were identified as Spirometra erinaceieuropaei using multiplex PCR and cox1 gene sequencing. | Hwang, Yang-Ha; Son, Wonsoo; Kim, Yong-Won; Kang, Dong-Hun; Chang, Hyun-Ha; Goo, Youn-Kyoung; Hong, Yeonchul; Chung, Dong-Il | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Neurol, Daegu 41944, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Neurosurg, Daegu 41944, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Radiol, Daegu 41944, South Korea; Kyungpook Natl Univ, Dept Internal Med, Sch Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Dept Parasitol & Trop Med, Sch Med, Daegu 41944, South Korea | HWANG, Yang-Ha/F-3068-2013 | 7402311308; 36676729400; 56203298200; 8977805800; 7407521688; 22937863200; 7403392847; 13310373300 | kuku1819@knu.ac.kr; | KOREAN JOURNAL OF PARASITOLOGY | KOREAN J PARASITOL | 0023-4001 | 1738-0006 | 58 | 3 | SCIE | PARASITOLOGY | 2020 | 1.341 | 82.9 | 0.16 | 2025-06-25 | 2 | 2 | Spirometra erinaceieuropaei; intravascular; sparganosis; stroke | CEREBRAL SPARGANOSIS; DECIPIENS PLEROCERCOIDS; CT; HEMORRHAGE | Intravascular; Sparganosis; Spirometra erinaceieuropaei; Stroke | Aged, 80 and over; Animals; Asian Continental Ancestry Group; Cerebral Arteries; Humans; Male; Sparganosis; Sparganum; Spirometra; Stroke; Thrombectomy; genomic DNA; aged; aphasia; Article; brain infection; brain ischemia; case report; cerebral intravascular sparganosis; clinical article; computed tomographic angiography; computer assisted tomography; consciousness disorder; cox1 gene; diffusion weighted imaging; facial nerve paralysis; gene; gene sequence; hemiparesis; human; hypertension; Korean (people); mechanical thrombectomy; middle cerebral artery occlusion; multiplex polymerase chain reaction; neurologic examination; nonhuman; sparganosis; sparganum; Spirometra; Spirometra erinaceieuropaei; university hospital; very elderly; weakness; animal; Asian continental ancestry group; brain artery; cerebrovascular accident; diagnostic imaging; genetics; isolation and purification; male; parasitology; procedures; sparganosis; sparganum; Spirometra; thrombectomy | English | 2020 | 2020-06 | 10.3347/kjp.2020.58.3.309 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Morphological and Molecular Characterization of Toxocara apodemi (Nematoda: Ascarididae) from Striped Field Mice, Apodemus agrarius, in Korea | Adult ascarid worms from the field mice, Apodemus agrarius, were observed with a light and scanning electron microscope, and molecularly analized with 18S rRNA gene. In the scanning electron microscope, 3 prominent labia were present in the anterior end of male and female worms, but the interlabia and gubernaculum were absent. Scanning electron micrographs showed cervical alae as vestigial organs that looked like a slightly uplifted superficial sewing stitch. Total 6 pairs of post-cloacal papillae were observed on the tail of the male worms. The tail of female worms was blunt and conical shape with a spine-like structure, mucron. The eggs were sub-globular, coated with the albuminous layer and 73 by 82 mu m in average size. The superficial pits of T. apodemi egg (mean 8.6x 6.7 mu m) are obviously bigger than those of Toxocara spp. The partial sequence of 18S rRNA showed the sequence homology of Toxocara canis (99.6%), Toxocara cati (99.4%), Toxascaris leonine (99.4%), and Toxocara vitulorum (99.2%). Conclusively, it was confirmed that ascarid nematodes, Toxocara apodemi, recovered from striped field mice in Korea are taxonomically conspecific relationship with genus Toxocara and genetic divergence from other Toxocara species. | Kim, Hyeon Cheol; Hong, Eui Ju; Ryu, Si Yun; Park, Jinho; Cho, Jeong Gon; Yu, Do Hyeon; Chae, Joon Seok; Choi, Kyoung Seong; Park, Bae Keun | Kangwon Natl Univ, Coll Vet Med, Chunchon 24289, South Korea; Kangwon Natl Univ, Inst Vet Sci, Chunchon 24289, South Korea; Chungnam Natl Univ, Coll Vet Med, Daejeon 34134, South Korea; Chonbuk Natl Univ, Coll Vet Med, Iksan 54596, South Korea; Gyeongsang Natl Univ, Coll Vet Med, Jinju 52828, South Korea; Seoul Natl Univ, Res Inst Vet Sci, Lab Vet Internal Med, BK21 PLUS Program Creat Vet Sci Res, Seoul 08826, South Korea; Seoul Natl Univ, Coll Vet Med, Seoul 08826, South Korea; Kyungpook Natl Univ, Coll Ecol & Environm Sci, Sangju 37224, South Korea | 35345454300; 7102538351; 7402110916; 8730126700; 57206746290; 14623495400; 7102478039; 7403949556; 37043844700 | bkpark@cnu.w.kr;bkpark@cnu.ac.kr; | KOREAN JOURNAL OF PARASITOLOGY | KOREAN J PARASITOL | 0023-4001 | 1738-0006 | 58 | 4 | SCIE | PARASITOLOGY | 2020 | 1.341 | 82.9 | 0.08 | 2025-06-25 | 3 | 6 | Apodemus agrarius; Toxocara apodemi; molecular characterization; scanning electron microscopy; Korea | IDENTIFICATION; INFECTION; CANIS; CATI | Apodemus agrarius; Korea; Molecular characterization; Scanning electron microscopy; Toxocara apodemi | Animals; Female; Humans; Male; Microscopy, Electron, Scanning; Murinae; Republic of Korea; RNA, Helminth; RNA, Ribosomal, 18S; Toxocara; RNA 18S; helminth RNA; adult; animal tissue; Apodemus; Apodemus agrarius; Apodemus peninsulae; Article; cloaca; controlled study; female; genetic analysis; genetic variability; genotype; juvenile animal; Korea; male; molecular phylogeny; morphology; Mus musculus; nonhuman; parasite egg count; phylogenetic tree; postcloacal papilla; Rattus norvegicus; RNA analysis; RNA gene; RNA sequence; scanning electron microscopy; sequence alignment; sequence homology; sex difference; species difference; Toxascaris leonina; Toxocara; Toxocara apodemi; Toxocara canis; Toxocara cati; Toxocara vitulorum; animal; classification; genetics; human; isolation and purification; murine; parasitology; South Korea; Toxocara; ultrastructure | English | 2020 | 2020-08 | 10.3347/kjp.2020.58.4.403 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Fecal calprotectin is more accurate than fecal immunochemical test for predicting mucosal healing in quiescent ulcerative colitis: a prospective multicenter study | Objective: Non-invasive stool tests, including the fecal immunochemical test (FIT) and fecal calprotectin (FC), are reliable biomarkers for mucosal healing (MH) in ulcerative colitis (UC). However, which fecal test is superior for predicting MH in inactive UC patients requires evaluation. We aimed to compare the accuracy of FIT and FC results for predicting MH in quiescent UC patients. Methods: This prospective, multicenter study was conducted at three tertiary hospitals. UC patients in clinical remission for at least three months underwent colonoscopy and MH was evaluated using the Mayo endoscopic sub-score (MES). The receiver operating characteristic (ROC) curve and cutoff value with the best accuracy for predicting MH were assessed. Results: Among 127 patients, 65 (51.2%) showed MH (MES = 0). The area under the curve (AUC) for predicting MH (MES = 0) was significantly higher for FC than for FIT (AUC 0.858 (95% confidence interval (CI) 0.784-0.913) vs. 0.707 (95% CI 0.620-0.784), p < .001); there was no difference when MH included MES = 1 (MES <= 1) (AUC 0.820 (95% CI 0.742-0.883) vs. 0.813 (95% CI 0.734-0.877), p = .891). When the cutoff value was 70 mu g/g for FC and 10 ng/mL for FIT, the sensitivity, specificity, positive predictive value and negative predictive value were 89.2, 71, 76.3, and 86.3, respectively, for FC and 92.3, 50, 65.9, and 86.1, respectively, for FIT. Conclusion: FC is more accurate than FIT for predicting MH in quiescent UC patients. The superiority of FC might be related to the distinctive performance of FC in differentiating inflammatory levels, particularly in low-grade mucosal activity. | Kim, Eun Soo; Lee, Hyun Seok; Kim, Sung Kook; Kim, Eun Young; Jang, Byung Ik; Kim, Kyeong Ok; Yang, Chang Heon; Lee, Yoo Jin | Kyungpook Natl Univ, Sch Med, Dept Internal Med, Div Gastroenterol, Daegu, South Korea; Catholic Univ Daegu, Dept Internal Med, Div Gastroenterol, Sch Med, Daegu, South Korea; Yeungnam Univ, Dept Internal Med, Div Gastroenterol, Coll Med, Daegu, South Korea; Dongguk Univ, Dept Internal Med, Sch Med, Div Gastroenterol, Gyeongju, South Korea; Keimyung Univ, Sch Med, Dept Internal Med, Div Gastroenterol, Daegu, South Korea | Kim, Eun Young/JCE-3602-2023; Lee, Hyun/D-5004-2011; Kwak, Sang Gyu/AAG-4341-2021; Kim, Sang/J-5398-2012; Lee, Yoojin/AAB-9799-2022 | 57203086704; 36647886100; 34770060400; 58889004100; 22953491400; 53363798100; 23089577400; 55531365900 | jbi@med.yu.ac.kr; | SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY | SCAND J GASTROENTERO | 0036-5521 | 1502-7708 | 55 | 2 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2020 | 2.425 | 83.2 | 0.59 | 2025-06-25 | 7 | 8 | Fecal calprotectin; fecal immunochemical test; ulcerative colitis; remission | INFLAMMATORY-BOWEL-DISEASE; RISK | Fecal calprotectin; fecal immunochemical test; remission; ulcerative colitis | Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers; Colitis, Ulcerative; Colonoscopy; Feces; Female; Hemoglobins; Humans; Immunochemistry; Intestinal Mucosa; Leukocyte L1 Antigen Complex; Male; Middle Aged; Occult Blood; Predictive Value of Tests; Prospective Studies; Republic of Korea; ROC Curve; Severity of Illness Index; Tertiary Care Centers; Wound Healing; Young Adult; calgranulin; biological marker; calgranulin; hemoglobin; adolescent; adult; aged; Article; colon mucosa; confidence interval; feces level; female; human; immunochemistry; major clinical study; male; Mayo endoscopic sub score; predictive value; priority journal; prospective study; receiver operating characteristic; scoring system; ulcerative colitis; chemistry; clinical trial; colonoscopy; comparative study; feces; immunochemistry; intestine mucosa; metabolism; middle aged; multicenter study; occult blood; pathology; severity of illness index; South Korea; tertiary care center; ulcerative colitis; very elderly; wound healing; young adult | English | 2020 | 2020-02-01 | 10.1080/00365521.2020.1714716 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Association between Sleep Problems and Sedentary Behaviors during Work among Korean Workers | Background: We aimed to identify the association between sleep problems and sedentary behaviors during work among Korean workers. Methods: We employed a cross-sectional survey, and analyzed data from the 5th Korean Working Conditions Survey, conducted in 2017. The participants were 50,205 workers aged 15 years and above. The data were analyzed using Pearson's correlation, chi-square distribution, and logistic regression. Results: Sleep problems occurred more frequently among female participants with higher ages; those with low educational levels; skilled agricultural, forestry, and fishery workers; elementary workers; and service and sales workers. With general characteristics as control variables, it was found that the odds of sleep problems were 5.547 times higher if the duration of sedentary behavior was longer. Conclusion: It is important to improving work environment and provide education on various physical activities for workers with a long duration of sedentary behaviors to reduce sleep problems among them. | Lee, Eunmi; Kim, Yujeong; Lee, Haeyoung | Hoseo Univ, Dept Nursing, 20,Hoseo Ro 79, Asan 31499, South Korea; Kyungpook Natl Univ, Coll Nursing, 680 Gukchabosangro, Daegu 41944, South Korea; Chung Ang Univ Red Cross, Coll Nursing, 84 Heukseok Ro, Seoul 06974, South Korea | Lee, Eunmi/AAS-2561-2020 | 57202264064; 57200941945; 57205471062 | cybericu@naver.com; | IRANIAN JOURNAL OF PUBLIC HEALTH | IRAN J PUBLIC HEALTH | 2251-6085 | 2251-6093 | 49 | 9 | SCIE;SSCI | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | 2020 | 1.429 | 83.5 | 0 | 2025-06-25 | 0 | 0 | Employees; Working conditions; Sleep problems | DURATION; INSOMNIA; TIME; METAANALYSIS; PREVALENCE; QUALITY; THERAPY; WOMEN; SEX | Employees; Sleep problems; Working conditions | English | 2020 | 2020-09 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Effectiveness of adjuvant treatment for morcellated, International Federation of Gynecology and Obstetrics stage I uterine leiomyosarcoma: A Korean multicenter study | Aim To evaluate the effectiveness of adjuvant treatment for morcellated, uterus-confined leiomyosarcoma in a multicenter setting. Methods We identified patients with International Federation of Gynecology and Obstetrics stage I uterine leiomyosarcoma primarily treated with surgery between 2003 and 2016. Among them, patients who underwent one of the following morcellation methods were included: (i) power morcellation; (ii) intracorporeal morcellation using scalpels or electrocautery; and (iii) vaginal morcellation. Patients' survival outcomes were compared according to the implementation of adjuvant treatment. Results From 13 institutions, 55 patients were included; 31 for adjuvant treatment group and 24 for surgery only group. The clinicopathological characteristics including the mass size, morcellation methods, extent of surgery, and mitotic count were similar between the groups. In the adjuvant treatment group, 67.7%, 19.4% and 12.9% of patients received chemotherapy, chemoradiation and radiation, respectively. After a median follow-up of 50.5 months, the adjuvant treatment and surgery only groups showed similar overall survival (5-year rate, 92.0% vs 90.4%; P = 0.959). No significant difference in progression-free survival was observed between the two groups (3-year rate, 46.1% vs 78.2%; P = 0.069). On multivariate analyses, adjuvant treatment did not affect progression-free survival (adjusted HR, 2.138; 95% CI, 0.550-8.305; P = 0.273). The adjuvant treatment group showed a trend towards more common distant metastasis, compared to the surgery only group (25.8% vs 4.2%; P = 0.062). The incidences of pelvic, retroperitoneal, and abdominal recurrences were not different between the groups. Conclusion Despite its frequent use in clinical practice, adjuvant treatment did not improve the survival outcomes of patients with morcellated, International Federation of Gynecology and Obstetrics stage I uterine leiomyosarcoma. | Kim, Se Ik; Choi, Chel Hun; Kim, Kidong; Hong, Deok Ho; Park, Jeong-Yeol; Kwon, Byung Su; Lee, Keun Ho; Hong, Dae Gy; Shin, So-Jin; Park, Sang-Il; Kim, Yun Hwan; Lee, Seung-Ho; Lee, Sanghoon; Hong, Jin Hwa; Lee, Jung-Yun; Kim, Yong Beom; No, Jae Hong; Suh, Dong Hoon | Seoul Natl Univ, Dept Obstet & Gynecol, Coll Med, Seoul, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Obstet & Gynecol, Sch Med, Seoul, South Korea; Univ Ulsan, Asan Med Ctr, Dept Obstet & Gynecol, Coll Med, Seoul, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Obstet & Gynecol, Seoul, South Korea; Ewha Womans Univ, Coll Med, Dept Obstet & Gynecol, Seoul, South Korea; Korea Univ, Dept Obstet & Gynecol, Anam Hosp, Seoul, South Korea; Korea Univ, Coll Med, Guro Hosp, Dept Obstetr & Gynecol, Seoul, South Korea; Yonsei Univ, Coll Med, Inst Womens Life Med Sci, Dept Obstet & Gynecol, Seoul, South Korea; Seoul Natl Univ, Dept Obstet & Gynecol, Bundang Hosp, 82 Gumi Ro 173 Beon Gil, Seongnam Si 13620, Gyeonggi Do, South Korea; Dongtan Jeil Hosp, Hwaseong, South Korea; Pusan Natl Univ, Sch Med, Dept Obstet & Gynecol, Busan, South Korea; Dongnam Inst Radiol & Med Sci, Dept Gynecol Oncol, Busan, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Gynecol Oncol, Daegu, South Korea; Keimyung Univ, Dept Obstet & Gynecol, Sch Med, Daegu, South Korea; Gachon Univ, Coll Med, Gil Med Ctr, Dept Obstet & Gynecol, Incheon, South Korea | Park, Kyoung Un/J-5473-2012; Lee, Jung-Seok/L-6826-2019; Lee, Hosun/E-9867-2011; Hong, Jinhwa/AAY-9037-2020; Kim, Kwang Pyo/AAG-1815-2020 | 55975744500; 11939248200; 35740868200; 57212214012; 15080981100; 57190952625; 57203464464; 26656670100; 23006860000; 35277485900; 55763947200; 57192299961; 56813014800; 24576766000; 56191369600; 57557360800; 23976823300; 36238538700 | kidong.kim.md@gmail.com; | JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH | J OBSTET GYNAECOL RE | 1341-8076 | 1447-0756 | 46 | 2 | SCIE | OBSTETRICS & GYNECOLOGY | 2020 | 1.73 | 83.7 | 0.48 | 2025-06-25 | 7 | 6 | adjuvant treatment; leiomyosarcoma; prognosis; recurrence; survival; uterine neoplasms | POWER MORCELLATION; CHEMOTHERAPY; SURVIVAL; SARCOMAS; OUTCOMES; IMPACT; CANCER; HYSTERECTOMY; RADIOTHERAPY; PROGNOSIS | adjuvant treatment; leiomyosarcoma; prognosis; recurrence; survival; uterine neoplasms | Adult; Combined Modality Therapy; Female; Humans; Leiomyosarcoma; Middle Aged; Morcellation; Retrospective Studies; Uterine Neoplasms; cisplatin; docetaxel; doxorubicin; etoposide; gemcitabine; ifosfamide; paclitaxel; adult; Article; cancer adjuvant therapy; cancer chemotherapy; cancer recurrence; cancer staging; cauterization; chemoradiotherapy; distant metastasis; female; follow up; human; hysterectomy; intracorporeal morcellation; major clinical study; morcellation; multicenter study; multivariate analysis; myomectomy; outcome assessment; overall survival; power morcellation; progression free survival; South Korea; uterus sarcoma; vaginal morcellation; clinical trial; comparative study; leiomyosarcoma; middle aged; morcellation; mortality; multimodality cancer therapy; retrospective study; uterus cancer | English | 2020 | 2020-02 | 10.1111/jog.14171 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | An Insight on the Role of Nitric Oxide in Yeast Apoptosis of Curcumin-Treated Candida albicans | Nitric Oxide (NO) is a widely studied molecule due to its diverse biological functions. One of its activities, induction of apoptosis, is currently an area of active investigation in mammalian cells. However, there exists little information regarding the role of NO in yeast apoptosis. In an effort to investigate the mode of action by which NO induces programmed cell death in Candida albicans, we conducted a study on curcumin, a major bioactive compound, which is known as a potential apoptosis-inducing material due to several of its biological activities. First, NO generation was evaluated upon curcumin treatment. It is widely known that NO production is closely tied to cellular respiration, which is regulated by mitochondria. An increase in NO concentration leads to the inhibition of respiration and mitochondrial dysfunction. The hallmarks of mitochondrial dysfunction include a decrease in mitochondrial membrane potential along with increased mitochondrial mass, calcium concentration and ROS generation. A specific oxidative ROS compound, superoxide (O-2(-)), is strongly reactive with NO to form peroxynitrite (ONOO-). ONOO- disturbs intracellular redox levels, decreasing the overall ratio of glutathione (GSH). This leads to oxidative damage in C. albicans, triggering lethal DNA damage that eventually results in apoptosis. In the present study, a nitric oxide synthase (NOS) inhibitor, L-NG-Nitroarginine Methyl Ester (L-NAME), was used in each experiment. In all experiments, L-NAME pre- treatment of cells blocked the effects induced by curcumin, which indicates that nitric oxide is a component of the overall mechanism. In conclusion, NO account for an indispensable position in apoptosis of curcumin-treated C. albicans. | Kwun, Min Seok; Lee, Dong Gun | Kyungpook Natl Univ, Sch Life Sci, BK 21 Plus KNU Creat BioRes Grp, Daegu 41566, South Korea | Lee, Dong-Gun/IWD-9833-2023 | 57212491555; 55668060900 | dglee222@knu.ac.kr; | CURRENT MICROBIOLOGY | CURR MICROBIOL | 0343-8651 | 1432-0991 | 77 | 10 | SCIE | MICROBIOLOGY | 2020 | 2.188 | 84.2 | 0.4 | 2025-06-25 | 7 | 8 | OXIDATIVE STRESS; DNA-DAMAGE; GLUTATHIONE; OXYGEN; ANTIFUNGAL; NO; PEROXYNITRITE; INACTIVATION; SUPEROXIDE; TRIGGERS | Animals; Apoptosis; Candida albicans; Curcumin; NG-Nitroarginine Methyl Ester; Nitric Oxide; Reactive Oxygen Species; curcumin; glutathione; n(g) nitroarginine methyl ester; nitric oxide; nitric oxide synthase; peroxynitrite; reactive oxygen metabolite; superoxide; curcumin; reactive oxygen metabolite; apoptosis; Article; Candida albicans; cell respiration; comparative study; controlled study; DNA damage; enzyme activation; fluorescence intensity; mitochondrial membrane potential; mitochondrion; nonhuman; oxidation reduction state; oxidative stress; priority journal; TUNEL assay; animal; apoptosis; Candida albicans | English | 2020 | 2020-10 | 10.1007/s00284-020-02132-x | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Comamonas flocculans sp. nov., a Floc-Forming Bacterium Isolated from Livestock Wastewater | A Gram-negative, aerobic, non-motile, rod-shaped, floc-forming, and non-spore-forming bacterium, designated as NLF-7-7(T), was isolated from the biofilm of a sample collected from a livestock wastewater treatment plant in Nonsan, Republic of Korea. Strain NLF-7-7(T), forms a visible floc and grows in the flocculated state. Cells of strain NLF-7-7(T) grew optimally at pH 6.5 and 30 degrees C and in the presence of 0.5% (w/v) NaCl. Phylogenetic analysis based on 16S rRNA gene sequences revealed that strain NLF-7-7(T) belonged to the family Comamonadaceae, and was most closely related to Comamonas badia DSM 17552(T) (95.8% similarity) and Comamonas nitrativorans 23310(T) (94.0% similarity). The phylogenetic and phenotypic data indicate strain NLF-7-7(T) is clearly distinguished from the Comamonas lineage. The major cellular fatty acids were C-10:0 3OH, C-16:0, and summed feature 3 (C-16:1 omega 6c/C-16:1 omega 7c). The respiratory quinone was Q-8. The polar lipids were composed of diphosphatidylglycerol, phosphatidylglycerol, phosphatidylethanolamine, and an unidentified aminolipid. The DNA G+C content of strain NLF-7-7 was 68.0 mol%. Based on the phenotypic, chemotaxonomic, and phylogenetic properties, strain NLF-7-7(T) represents a novel species of the genus Comamonas, for which the name Comamonas flocculans sp. nov. is proposed. The type strain is C. flocculans NLF-7-7(T) (=KCTC 62943(T)). The GenBank/EMBL/DDBJ accession number for the 16S rRNA gene sequence of Comamonas flocculans NLF-7-7(T) is MN527436. The whole-genome shotgun BioProject Number is PRJNA555370 with the Accession Number CP042344. | Kim, Dong-Hyun; Han, Kook-Il; Kwon, Hae-Jun; Kim, Mi-Gyeong; Kim, Young-Guk; Choi, Doo-Ho; Lee, Keun Chul; Suh, Min Kuk; Kim, Han Sol; Lee, Jung-Sook; Kim, Jong-Guk | Kyungpook Natl Univ, Sch Appl Biosci, Daegu 37224, South Korea; Korea Res Inst Biosci & Biotechnol, Korean Collect Type Cultures, 181 Ipsin Gil, Jeongeup Si 56212, Jeollabuk Do, South Korea; Univ Sci & Technol UST, 217 Gajeong Ro, Daejeon 34113, South Korea; Kyungpook Natl Univ, BK21 Plus KNU Creat BioRes Grp, Sch Life Sci & Biotechnol, Daegu 41566, South Korea | Kim, Dong Hyun/LDT-2672-2024; Kim, Sunwon/AAY-8551-2020; Lee, SangHun/GPW-6306-2022; Lee, JongHee/AAH-4129-2019 | 59971802600; 54381608700; 57211267067; 57211276026; 57211274842; 57211275161; 57205562889; 57201458098; 57211265112; 56052405400; 35277198800 | jslee@kribb.re.kr;kimjg@knu.ac.kr; | CURRENT MICROBIOLOGY | CURR MICROBIOL | 0343-8651 | 1432-0991 | 77 | 8 | SCIE | MICROBIOLOGY | 2020 | 2.188 | 84.2 | 0.4 | 2025-06-25 | 5 | 5 | EMENDED DESCRIPTION; SEQUENCES | Animals; Bacterial Typing Techniques; Base Composition; Comamonas; DNA, Bacterial; Fatty Acids; Genome, Bacterial; Livestock; Phospholipids; Phylogeny; Republic of Korea; RNA, Ribosomal, 16S; Sequence Analysis, DNA; Ubiquinone; Waste Water; cardiolipin; fatty acid; phosphatidylethanolamine; phosphatidylglycerol; quinone derivative; RNA 16S; sodium chloride; bacterial DNA; phospholipid; ubiquinone; ubiquinone 8; Article; bacterial strain; bacterium isolation; chemotaxonomy; Comamonadaceae; Comamonas; Comamonas badia; Comamonas flocculans; Comamonas nitrativorans; DNA base composition; gene sequence; lipid composition; livestock; nonhuman; nucleotide sequence; pH; phenotype; phylogeny; priority journal; South Korea; type strain; waste water; waste water treatment plant; animal; bacterial genome; bacterium identification; chemistry; classification; Comamonas; DNA sequence; genetics; isolation and purification; livestock; microbiology; phylogeny; wastewater | English | 2020 | 2020-08 | 10.1007/s00284-020-01940-5 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Lysobacter segetis sp. nov., Isolated from Soil | A Gram-negative, aerobic, motile by gliding, rod-shaped bacterium, strain 17J68-2(T), was isolated from a soil sample taken from Jeju Island, Republic of Korea. The isolate displayed high 16S rRNA gene sequence similarity to the members of the genus Lysobacter in the family Lysobacteraceae, with Lysobacter humi FJY8(T) (98.4% similarity), Lysobacter xinjiangensis RCML-52(T) (98.3%), and Lysobacter mobilis 9NM-14(T) (98.1%) as closest phylogenetic neighbors. Growth of strain 17J68-2(T) occurred at 15-42 degrees C, pH 7-8, and in the presence of 0-1.0% NaCl. Draft genome was 2.94 Mb in size with G+C content of 70.5 mol%. The major polar lipids were phosphatidylglycerol, diphosphatidylglycerol, and phosphatidylethanolamine. Ubiquinone Q-8 was the predominant respiratory quinone and the major fatty acids were C-16:0 iso (39.4%), summed feature 3 (C-16:1 omega 7c/C-16:1 omega 6c) (6.6%), C-11:0 iso 3-OH (6.4%), C-15:0 iso (6.4%), and C-16:1 iso H (6.2%). The DNA-DNA relatedness between strain 17J68-2(T) and L. humi, L. xinjiangensis, and L. mobilis were 39.9, 39.4, and 25.3%, respectively. From these results, it is concluded that the novel isolate possesses sufficient characteristics to differentiate it from the most closely affiliated Lysobacter species, and strain 17J68-2(T) represents a novel species of the genus Lysobacter, for which the name Lysobacter segetis sp. nov. (=KCTC 62237(T) = JCM 33058(T)) is proposed. | Ten, Leonid N.; Jeon, Jongguen; Elderiny, Nabil Salah; Kim, Myung Kyum; Lee, Seung-Yeol; Jung, Hee-Young | Kyungpook Natl Univ, Sch Appl Biosciences, Daegu, Daegu Gwang'yeo, South Korea; Seoul Women's Univ, Dept Bio, Environm Technol, Seoul, Seoul, South Korea; Kyungpook Natl Univ, Inst Plant Med, Daegu, Daegu Gwang'yeo, South Korea | ; Elderiny, Nabil/AAL-2684-2020; Lee, Hye Ah/ABC-8131-2021; Ten, Leonid/P-7941-2014; Kim, Jung Oh/JDC-5061-2023 | 6603039265; 57196005347; 57195424553; 35080583500; 56106499600; 7403029383 | heeyoung@knu.ac.kr; | CURRENT MICROBIOLOGY | CURR MICROBIOL | 0343-8651 | 1432-0991 | 77 | 1 | SCIE | MICROBIOLOGY | 2020 | 2.188 | 84.2 | 0.24 | 2025-06-25 | 4 | 5 | PROKARYOTIC GENOME ANNOTATION; HYBRIDIZATION; SEQUENCES; GENE | Bacterial Typing Techniques; Base Composition; DNA, Bacterial; Lysobacter; Phylogeny; RNA, Ribosomal, 16S; Soil Microbiology; cardiolipin; DNA; fatty acid; phosphatidylethanolamine; phosphatidylglycerol; RNA 16S; ubiquinone; bacterial DNA; RNA 16S; Article; bacterium isolate; chemotaxonomy; DNA base composition; DNA DNA hybridization; gene sequence; genome; Lysobacter; Lysobacter humi; Lysobacter mobilis; Lysobacter segetis; Lysobacter xinjiangensis; nonhuman; pH; phenotype; phylogeny; priority journal; soil; bacterium identification; classification; genetics; Lysobacter; metabolism; microbiology | English | 2020 | 2020-01 | 10.1007/s00284-019-01801-w | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Incidence and Distribution of Respiratory Microorganisms Causing Acute Respiratory Infections at the University Hospital of Korea | Background: Acute respiratory infection caused by respiratory microorganisms including various kinds of viruses and bacteria is the most common infectious disease. When managing patients, it is crucial to detect these microorganisms rapidly and monitor their occurrence and tendency. Recently, the methods of detecting them have been implemented by molecular diagnostics. The authors intended to investigate their incidence and distribution and identify the significance of the molecular diagnosis for their detection. Methods: The retrospective study was conducted to investigate the incidence and distribution of respiratory microorganisms according to the age, gender, month, season, and the detection method and to analyze their co-infections from July 2016 to December 2019. In addition, the four types of turn-around time (TAT) for each detection method were also analyzed. Results: The overall incidence for at least one respiratory microorganism was 23.1% (3,645/15,808). The highest incidence was identified in age group 2 (1 - 3 months), 38.5%. The incidence rates by multiplex PCR using Anyplex and Allplex, FilmArray method, and influenza virus (flu) antigen detection test were 44.2% (718/1,625), 63.1% (1,198/1,899), and 14.1% (1,729/12,284), respectively. The overall incidence between male and female patients showed no statistically significant difference (p = 0.980), except for the flu antigen detection test (p = 0.000). Influenza A viruses (flu A) accounted for the highest percentage (34.9%), followed by rhinovirus/enterovirus (20.5%), RSV (12.8%), flu B (8.3%), and adenovirus (7.6%). These microorganisms showed characteristic distribution patterns according to season and month. Flu A and flu B predominated in winter and accounted for an increasing proportion as age increased according to the age groups. The overall co-infection rate was 22.5% (432/1,916). The average TATs of the FilmArray method were significantly much faster than multiplex PCR using Anyplex and Allplex (p = 0.000). Conclusions: The information on the incidence and distribution of respiratory microorganisms and their expeditious detection are considered critical to the management of the elderly, immunocompromised patients, and children. The rapid molecular-based diagnosis of respiratory infections would be beneficial in medical decision and prevention of their propagation. | Ham, J. Y.; Song, K. E.; Lee, N. Y. | Kyungpook Natl Univ, Dept Lab Med, Chilgok Hosp, 807 Hoguk Ro, Daegu 41404, South Korea; Kyungpook Natl Univ, Sch Med, Dept Clin Pathol, Daegu, South Korea | lee, nan/HZM-0321-2023 | 56464754800; 57843936100; 57209204358 | leenanyoung70@gmail.com; | CLINICAL LABORATORY | CLIN LAB | 1433-6510 | 66 | 12 | SCIE | MEDICAL LABORATORY TECHNOLOGY | 2020 | 1.138 | 84.5 | 0.16 | 2025-06-25 | 5 | 4 | acute respiratory infection; respiratory microorganisms; molecular diagnosis; incidence and distribution; co-infections | TRACT INFECTIONS; MULTIPLEX PCR; VIRUS; CHILDREN; IMPACT; ASSAY; PANEL; TIME | Acute respiratory infection; Coinfections; Incidence and distribution; Molecular diagnosis; Respiratory microorganisms | Aged; Bacteria; Child; Female; Humans; Incidence; Infant; Male; Republic of Korea; Respiratory Tract Infections; Retrospective Studies; Viruses; Adenoviridae; adolescent; adult; antigen detection; Article; autumn; Bordetella pertussis; bronchial aspiration procedure; child; Chlamydia pneumoniae; controlled study; Enterovirus; female; human; Human adenovirus 7; Human respiratory syncytial virus; immunocompromised patient; incidence; infant; infection rate; Influenza A virus; Influenza B virus; Korea; major clinical study; male; microorganism detection; mixed infection; molecular diagnosis; multiplex polymerase chain reaction; Mycoplasma pneumoniae; newborn; nonhuman; nose smear; real time reverse transcription polymerase chain reaction; respiratory tract infection; retrospective study; Rhinovirus; seasonal variation; species distribution; spring; summer; throat culture; university hospital; virus detection; winter; aged; bacterium; isolation and purification; microbiology; respiratory tract infection; South Korea; virology; virus | English | 2020 | 2020 | 10.7754/clin.lab.2020.200441 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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