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| ○ | ○ | Article | Complete genome of single locus sequence typing D1 strain Cutibacterium acnes CN6 isolated from healthy facial skin | ObjectivesCutibacterium acnes is a Gram-positive bacterium commonly found on human skin, particularly in sebaceous areas. While it is typically considered a commensal, specific strain types based on single locus sequence typing (SLST) have been associated with pathogenic conditions or healthy skin. Recently, SLST D1 strains, part of phylotype IA1, have received attention for their potential benefits related to skin health. However, their genetic characteristics remain underexplored. Therefore, the whole genome of C. acnes CN6, an SLST D1 strain isolated from the facial skin of a healthy individual, was sequenced to expand the understanding of SLST D1 strains and identify genomic features that may support skin health.Data descriptionThe whole genome sequencing of C. acnes CN6 was conducted using MinION reads based on de novo assembly, revealing a single circular complete chromosome. With the length of 2,550,458 bp and G + C content of 60.04%, the genome contains 2,492 genes, including 2,433 CDSs, 9 rRNAs, 46 tRNAs, 4 ncRNAs, and 134 pseudo genes. Previously predicted virulence proteins of C. ances were detected in the genome. Genome comparation with 200 C. acnes strains isolated from healthy facial skin revealed SLST D1 strain-specific genes and a unique variant of the znuC gene in D1 strains. | Kim, Ikwhan; Jung, Da-Ryung; Kim, Ryeong-Hui; Lee, Dokyung; Jung, Yeongyun; Ha, Ji Hoon; Lee, Eun Kyung; Kim, Jin Mo; Kim, Jin Young; Jang, Jun-Hwan; Bae, Jun-Tae; Cho, Yoon Soo; Shin, Jae-Ho | Kyungpook Natl Univ, Dept Integrat Biol, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea; Kyungpook Natl Univ, NGS Core Facil, Daegu 41566, South Korea; Hallym Univ, Coll Med, Hangang Sacred Heart Hosp, Burn Inst, Seoul 07247, South Korea; Kolmar Korea, R&D Ctr, Seoul 06800, South Korea; Hallym Univ, Coll Med, Hangang Sacred Heart Hosp, Dept Rehabil Med, Seoul 07247, South Korea; J2KBIO, Chungbuk 28104, South Korea | shin, Jaeho/K-6792-2013; Kim, Jin/B-7077-2012; Lee, Eunkyung/AAG-1192-2019; Cho, Yoon Soo/JXL-2899-2024 | 58643019600; 57221116102; 57222756419; 57961974700; 57197833801; 58626062200; 57230063400; 59403513100; 59403558900; 59403559000; 58175572800; 56059636900; 57224125922 | yschorm@hallym.ac.kr;jhshin@knu.ac.kr; | BMC GENOMIC DATA | BMC GENOMIC DATA | 2730-6844 | 25 | 1 | SCIE | GENETICS & HEREDITY | 2024 | 2.5 | 49.5 | 0 | 2025-05-07 | 0 | 0 | Cutibacterium acnes; Single-locus sequence typing (SLST); Healthy skin; Whole genome sequencing; De novo assembly | Cutibacterium acnes; De novo assembly; Healthy skin; Single-locus sequence typing (SLST); Whole genome sequencing | Base Composition; Face; Genome, Bacterial; Humans; Phylogeny; Propionibacterium acnes; Skin; Whole Genome Sequencing; ribosome RNA; transfer RNA; untranslated RNA; Article; bacterial gene; bacterial genetics; bacterium isolation; chromosome size; comparative study; DNA base composition; gene locus; genetic variability; human; nonhuman; prediction; Propionibacterium acnes; protein analysis; pseudogene; skin flora; whole genome sequencing; znuC gene; bacterial genome; face; genetics; isolation and purification; microbiology; phylogeny; skin; whole genome sequencing | English | 2024 | 2024-11-05 | 10.1186/s12863-024-01277-z | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | A numerical study on airflow and particle transport characteristics of subjects with cement dust exposure | Exposure to cement dust can cause respiratory problems and structural changes in respiratory airways. Computed tomography (CT) has shown that the airways of individuals with cement dust exposure (CDE) exhibit narrowing, wall thickening, and altered bifurcation angles. This study aimed to investigate the differences in airflow structure and particle transport between individuals with CDE and those with non-cement dust exposure (NCDE). To this end, computational fluid dynamics and Lagrangian particle tracking specialized for the respiratory system were employed, and two particle models representing cement dust and microdust were established. To construct three-dimensional airway models, CT images were obtained from four subjects with CDE and four with NCDE. Physiologically accurate small airways were virtually established to explore the flow structures in CT-unresolved regions. Subjects with NCDE showed higher wall shear stress and pressure drops in the lower lobes than in the upper lobes of the lungs. Conversely, subjects with CDE showed higher wall shear stress and pressure drops in the upper lobes than in the lower lobes. Furthermore, the narrowed airways of subjects with CDE caused strong dissipation, turbulence, and secondary flows, exacerbating the deposition of cement dust in the corresponding regions. However, the microdust model showed consistently low deposition fractions in all airway models, indicating deep penetration into the lungs, regardless of respiratory health. Thus, CDE alters the airway structure and parenchymal function, which further affects fluid dynamics and particle deposition characteristics. This study elucidates the fluid flow and particle deposition patterns within airways narrowed by CDE. [GRAPHICS] . | Hwang, Jimin; Kim, Woo Jin; Chae, Kum Ju; Jin, Gong Yong; Lee, Chang Hyun; Cui, Xinguang; Choi, Sanghun | Kyungpook Natl Univ, Sch Mech Engn, 80 Daehak Ro, Daegu 41566, South Korea; Kangwon Natl Univ Hosp, Dept Internal Med, Chunchon, South Korea; Kangwon Natl Univ Hosp, Environm Hlth Ctr, Chunchon, South Korea; Jeonbuk Natl Univ, Jeonbuk Natl Univ Hosp, Inst Med Sci, Dept Radiol,Res Inst Clin Med,Biomed Res Inst, Jeonju, South Korea; Seoul Natl Univ, Coll Med, Seoul Natl Univ Hosp, Dept Radiol, Seoul, South Korea; Univ Iowa, Coll Med, Dept Radiol, Iowa City, IA USA; Huazhong Univ Sci & Technol, Sch Aerosp Engn, Wuhan, Peoples R China | Kim, Jong/J-2749-2012 | 59312869500; 56560422500; 57195310676; 55663719500; 57196253438; 50261346800; 55847101000 | s-choi@knu.ac.kr; | AEROSOL SCIENCE AND TECHNOLOGY | AEROSOL SCI TECH | 0278-6826 | 1521-7388 | 58 | 12 | SCIE | ENGINEERING, CHEMICAL;ENGINEERING, MECHANICAL;ENVIRONMENTAL SCIENCES;METEOROLOGY & ATMOSPHERIC SCIENCES | 2024 | 2.1 | 49.7 | 0 | 2025-05-07 | 0 | 0 | Vishal Verma | OBSTRUCTIVE PULMONARY-DISEASE; COMPUTATIONAL FLUID-DYNAMICS; BREATHING LUNG MODEL; PORTLAND-CEMENT; RESPIRATORY-TRACT; DEPOSITION; POLLUTION; BARRIER; AIRWAYS; PLANTS | Vishal Verma | Aerodynamics; Flow structure; Lagrange multipliers; Positive temperature coefficient; cement; Airway modeling; Cement dust; Fluid particles; Fluid-dynamics; Particle transport; Respiratory problems; Transport characteristics; Vishal verma; Wall shear stress; Wall-shear stress; aerosol; aged; airflow; Article; clinical article; computational fluid dynamics; controlled study; dust exposure; female; fluid flow; human; male; pressure; quantitative study; shear stress; x-ray computed tomography; Secondary flow | English | 2024 | 2024-12-01 | 10.1080/02786826.2024.2393829 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Review | Artificial intelligence- and computer-assisted navigation for shoulder surgery | Background: Over the last few decades, shoulder surgery has undergone rapid advancements, with ongoing exploration and the development of innovative technological approaches. In the coming years, technologies such as robot-assisted surgeries, virtual reality, artificial intelligence, patient-specific instrumentation, and different innovative perioperative and preoperative planning tools will continue to fuel a revolution in the medical field, thereby pushing it toward new frontiers and unprecedented advancements. In relation to this, shoulder surgery will experience significant breakthroughs. Main body: Recent advancements and technological innovations in the field were comprehensively analyzed. We aimed to provide a detailed overview of the current landscape, emphasizing the roles of technologies. Computer-assisted surgery utilizing robotic- or image-guided technologies is widely adopted in various orthopedic specialties. The most advanced components of computer-assisted surgery are navigation and robotic systems, with functions and applications that are continuously expanding. Surgical navigation requires a visual system that presents real-time positional data on surgical instruments or implants in relation to the target bone, displayed on a computer monitor. There are three primary categories of surgical planning that utilize navigation systems. The initial category involves volumetric images, such as ultrasound echogram, computed tomography, and magnetic resonance images. The second type is based on intraoperative fluoroscopic images, and the third type incorporates kinetic information about joints or morphometric data about the target bones acquired intraoperatively. Conclusion: The rapid integration of artificial intelligence and deep learning into the medical domain has a significant and transformative influence. Numerous studies utilizing deep learning-based diagnostics in orthopedics have remarkable achievements and performance. | Lee, Kang-San; Jung, Seung Ho; Kim, Dong-Hyun; Chung, Seok Won; Yoon, Jong Pil | Kyungpook Natl Univ, Sch Med, Dept Orthopaed Surg, Daegu, South Korea; Konkuk Univ, Sch Med, Dept Orthopaed Surg, Med Ctr, Seoul, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Orthoped Surg, 130 Dongdeok ro, Daegu 41944, South Korea | 58967020700; 58967020800; 57198637188; 37065938600; 36098548400 | altjp1@gmail.com; | JOURNAL OF ORTHOPAEDIC SURGERY | J ORTHOP SURG-HONG K | 1022-5536 | 2309-4990 | 32 | 1 | SCIE | ORTHOPEDICS;SURGERY | 2024 | 1.6 | 49.8 | 5.87 | 2025-04-16 | 5 | 6 | artificial intelligence; computer-assisted surgery; shoulder surgery; patient-specific instrumentation | PATIENT-SPECIFIC INSTRUMENTATION; GLENOID COMPONENT POSITION; TOTAL HIP-ARTHROPLASTY; INTRAOPERATIVE NAVIGATION; ACCURACY; IMPLANTATION; ROBOTICS; REALITY | artificial intelligence; computer-assisted surgery; patient-specific instrumentation; shoulder surgery | Artificial Intelligence; Fluoroscopy; Humans; Robotics; Shoulder; Surgery, Computer-Assisted; Article; artificial intelligence; augmented reality; computer assisted surgery; computer assisted tomography; deep learning; echography; fluoroscopy; human; morphometry; nuclear magnetic resonance imaging; perioperative period; robot assisted surgery; rotator cuff rupture; shoulder surgery; total hip replacement; total knee arthroplasty; total shoulder arthroplasty; ultrasound; virtual reality; visual system; volumetry; artificial intelligence; robotics; shoulder | English | 2024 | 2024-01 | 10.1177/10225536241243166 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Biomechanical and histological evaluation of aspirin in rotator cuff tear rat model | Background: Aspirin is a representative non-steroidal anti-inflammatory drug (NSAIDs) and has been commonly used for the treatment of tendinopathy in clinical practice. In this study, we aimed to evaluate the biomechanical and histological healing effects of aspirin on the healing of the tendon-to-bone interface after rotator cuff tear repair. Methods: A total of 20 male Sprague-Dawley rats were randomly divided into two groups of 10 rats each. Group-C performed repaironly, and group-aspirin treated with aspirin after tendon repair. Group-aspirin rat were intraperitoneally injected with aspirin at 10 mg/kg every 24 h for 7 days. Eight weeks after surgery, the left shoulder of each rat was used for histological analysis and the right shoulder for biomechanical analysis. Results: In the biomechanical analysis, there was no significant difference in load-to-failure (group-C: 0.61 +/- 0.32 N, group-aspirin: 0.74 +/- 0.91 N; p = .697) and ultimate stress (group-C: 0.05 +/- 0.01 MPa, group-aspirin: 0.29 +/- 0.43 MPa; p = .095). For the elongation (group-C: 222.62 +/- 57.98%, group-aspirin: 194.75 +/- 75.16%; p = .028), group-aspirin confirmed a lower elongation level than group-C. In the histological evaluation, the Bonar score confirmed significant differences in collagen fiber density (group-C: 1.60 +/- 0.52, group-aspirin: 2.60 +/- 0.52, p = .001) and vascularity (group-C: 1.00 +/- 0.47, group-aspirin: 2.20 +/- 0.63, p = .001) between the groups. Conclusions: Aspirin injection after rotator cuff tear repair may enhance the healing effect during the early remodeling phase of tendon healing. | Chung, Seok Won; Chung, Seung Ho; Kim, Dong-Hyun; Lee, Hyun Joo; Park, Eugene J.; Shim, Bum-Jin; Cho, Chul-Hyun; Yoon, Jong Pil | Konkuk Univ, Med Ctr, Sch Med, Dept Orthopaed Surg, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Orthopaed Surg, Daegu, South Korea; Keimyung Univ, Dongsan Hosp, Sch Med, Dept Orthoped Surg, Daegu, South Korea | Park, Eugene/P-1473-2018 | 37065938600; 57221219695; 57198637188; 58838750100; 55371642100; 57201499293; 35785599900; 36098548400 | altjp1@gmail.com; | JOURNAL OF ORTHOPAEDIC SURGERY | J ORTHOP SURG-HONG K | 1022-5536 | 2309-4990 | 32 | 2 | SCIE | ORTHOPEDICS;SURGERY | 2024 | 1.6 | 49.8 | 0 | 2025-05-07 | 0 | 0 | A Comparative Animal Study; NSAIDs; aspirin; biomechanical; histological; rotator cuff | REPAIR; INJURY; MUSCLE | A Comparative Animal Study; aspirin; biomechanical; histological; NSAIDs; rotator cuff | Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biomechanical Phenomena; Disease Models, Animal; Male; Rats; Rats, Sprague-Dawley; Rotator Cuff Injuries; Wound Healing; acetylsalicylic acid; collagen; acetylsalicylic acid; nonsteroid antiinflammatory agent; animal model; Article; biomechanics; bone structure; clinical practice; collagen fiber; controlled study; histology; male; Masson staining; muscle relaxation; nonhuman; physiological stress; rat; rotator cuff rupture; skin incision; tendinitis; tendon reconstruction; vascularization; animal; biomechanics; disease model; drug effect; drug therapy; pathology; rotator cuff injury; Sprague Dawley rat; wound healing | English | 2024 | 2024-05 | 10.1177/10225536241265827 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Development of precipitation-data-based real-time slope stability estimation method considering the uncertainty of soil hydraulic properties | An autoregressive longand short-term memory (ARLSTM) model was applied to develop a real-time probabilistic slope stability estimation model for the engineered barrier system (EBS) of a near surface radioactive waste disposal facility. The effectiveness of the developed model was verified using actual data acquired from South Korea, including precipitation, soil moisture contents, and inclinometer time-series data. The precipitation and the factor of safety (FS) ensemble results were used as the input and output variables of the AR-LSTM model, respectively, where the FS ensemble results were calculated by the Taylor model, integrating the Mualem-van Genuchten soil water retention model with consideration of the multivariate statistics on the hydrophysical properties of the soil. The estimation accuracy of the AR-LSTM model was reasonable by showing high correlation coefficient (0.9468) and low root mean squared error (0.0070) values between the actual and estimated FS values. Moreover, a significant correlation was observed between the estimated FS ensemble results and displacement events recorded by the inclinometer sensor. All the results suggest the effectiveness of the developed model for the long-term integrity assurance of the EBS. | Park, Heejeong; Jeong, Jiho; Kwon, Mijin; Cho, Chun-Hyung; Jun, Seong-Chun; Choi, Junghae; Jeong, Jina | Kyungpook Natl Univ, Dept Geol, Daegu, South Korea; Korea Radioact Waste Agcy KORAD, Daejeon, South Korea; Geogreen21 Co Ltd, Seoul, South Korea; Kyungpook Natl Univ, Dept Earth Sci Educ, Daegu, South Korea | 57226598607; 57218684286; 57195576048; 57220796131; 57195726847; 55839820300; 55488558800 | jeong.j@knu.ac.kr; | EPISODES | EPISODES | 0705-3797 | 47 | 3 | SCIE | GEOSCIENCES, MULTIDISCIPLINARY | 2024 | 2.2 | 49.8 | 0.46 | 2025-05-07 | 1 | 1 | MODEL; CONDUCTIVITY; LANDSLIDES; SUCTION | South Korea; hydraulic property; precipitation (climatology); real time; slope stability; soil moisture | English | 2024 | 2024-09 | 10.18814/epiiugs/2024/02403s02 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Food passage following proximal gastrectomy with double-tract reconstruction and its effect on nutritional status in early gastric cancer: a prospective single-center cohort study | Purpose: Laparoscopic proximal gastrectomy with double-tract reconstruction (LPG-DTR) expectedly results in improved nutritional status and less body weight loss than conventional total gastrectomy in upper-third gastric cancer. This study aimed to investigate the food passage patterns following LPG-DTR and its effect on nutritional outcomes up to 1 year after surgery. Methods: This prospective cohort study recruited 10 patients with early gastric cancer scheduled for LPG-DTR. Nutritional indices and body composition were assessed every 3 months up to 12 months. Liquid and solid food transits were evaluated with fluoroscopic upper gastrointestinal study and radionuclide scintigraphy, respectively. Results: At 12 months, patients exhibited a body weight loss of 14.5% +/- 3.6%. The main passage routes for liquid and solid foods differed, primarily via the interposed jejunum for liquids, whereas via both tracts for solids. The median half-life of solid food emptying from the remnant distal stomach was 105.1 minutes (range, 50.8-2,194.2 minutes), and duodenal passage of solid food was noted in 9 of 10 patients. Those with gastric half-emptying time > 3 hours demonstrated greater weight loss (19.5% +/- 1.4% vs. 12.5% +/- 1.1%, P = 0.024) and more pronounced reduction in serum albumin levels (-0.5 +/- 0.3 g/dL vs. 0.0 +/- 0.2 g/dL, P = 0.024) after 12 months. Conclusion: LPG-DTR demonstrated varying food passage patterns depending on the food contents and delayed solid food emptying from the remnant stomach was associated with more substantial weight loss. | Park, Ji Yeon; Park, Ki Bum; Lee, Seung Soo; Chung, Ho Young; Jeong, Shin Young; Lee, Sang-Woo; Kwon, Oh Kyoung | Kyungpook Natl Univ, Sch Med, Dept Surg, Daegu, South Korea; Kyungpook Natl Univ, Dept Surg, Chilgok Hosp, 807 Hoguk ro, Daegu 41404, South Korea; Kyungpook Natl Univ Hosp, Dept Surg, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Nucl Med, Daegu, South Korea | Lee, Sangwoo/MVV-2859-2025; Park, Ji Yeon/AAV-2471-2020 | 57196405216; 57220965452; 54400392100; 56008255800; 36164032500; 57196249819; 26536109900 | jybark99@knu.ac.kr; | ANNALS OF SURGICAL TREATMENT AND RESEARCH | ANN SURG TREAT RES | 2288-6575 | 2288-6796 | 106 | 6 | SCIE | SURGERY | 2024 | 1.6 | 49.8 | 0 | 2025-05-07 | 1 | 0 | Gastrectomy; Gastric emptying; Nutritional status; Radionuclide imaging; Stomach neoplasms | ANASTOMOSIS; MOTILITY | Gastrectomy; Gastric emptying; Nutritional status; Radionuclide imaging; Stomach neoplasms | English | 2024 | 2024-06 | 10.4174/astr.2024.106.6.313 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Identification of risk factors and clinical outcomes for symmetric peripheral gangrene: A new scoring system using a common data model database | Background: Symmetrical peripheral gangrene (SPG) is a destructive clinical condition where amputation is often the final treatment option. We aimed to identify the predictors of SPG using the common data model (CDM) and propose a new scoring system for predicting hospitalized patients at risk of developing SPG. Methods: A cohort of patients treated with intravenous noradrenaline, epinephrine, and vasopressin between 2011 and 2020 was retrospectively analyzed using the CDM database. The main outcome was amputation performed as a resuscitation measure. We investigated risk factors including demographic characteristics, comorbidities, and preoperative laboratory values. Based on demographic variables such as age and sex, a 1:10 propensity score matching (PSM) was performed. The odds ratio (OR) was calculated using logistic regression analysis. Results: Amputation was performed in 308 (0.4%) patients out of a cohort of 73,902 patients. Age, sex, hypertension, diabetes mellitus (DM), renal disease (RD), heart failure, anemia, hypercholesterolemia, peripheral vascular disease (PVD), and laboratory markers such as albumin, eosinophils, hematocrit, lymphocytes, monocytes, neutrophils, ESR, aPTT, creatinine, and BUN were statistically significant. Logistic regression analysis revealed statistically significant differences in DM (OR 5.51), RD (OR 2.90), PVD (OR 9.67), and cerebrovascular disease (CVD) (OR 0.49). Compared to the group without amputation, logistic regression analysis after matching the age and sex group with 1:10 PSM showed statistically significant results in DM (OR 3.59), RD (OR 2.59), PVD (OR 7.76), and CVD (OR 0.40). Conclusion: Early recognition of high-risk patients may help medical providers prevent severe outcomes, including amputation surgery. | Deslivia, Maria Florencia; Kim, Do-Hoon; Lee, Suk-Joong; Kim, Hee-June; Kholinne, Erica; Lee, Hyun-Joo | Kyungpook Natl Univ, Sch Med & Hosp, Dept Orthopaed Surg, 130 Dongduk Ro, Daegu 700721, South Korea; St Carolus Hosp, Dept Orthoped Surg, Jakarta, Indonesia; Kyungpook Natl Univ Hosp, Med Big Data Res Ctr, Daegu, South Korea; Daejeon Eulji Med Ctr, Dept Nucl Med, Daejeon, South Korea; Gyeongsang Natl Univ, Dept Orthopaed Surg, Sch Med, Chang Won, South Korea; Gyeongsang Natl Univ, Changwon Hosp, Chang Won, South Korea; Univ Trisakti, St Carolus Hosp, Fac Med, Dept Orthoped Surg, Jakarta, Indonesia | ; Deslivia, Maria Florencia/IAQ-9858-2023; Kholinne, Erica/AAW-9634-2020 | 56306551400; 55624468392; 57078230800; 36463735200; 57112598600; 58838750100 | lidmania@daum.net; | JOURNAL OF ORTHOPAEDIC SURGERY | J ORTHOP SURG-HONG K | 1022-5536 | 2309-4990 | 32 | 2 | SCIE | ORTHOPEDICS;SURGERY | 2024 | 1.6 | 49.8 | 1.06 | 2025-05-07 | 1 | 1 | common data model; gangrene; risk factors | DIGITAL GANGRENE; ASSOCIATION; OCCLUSIONS | common data model; gangrene; risk factors | Aged; Amputation, Surgical; Databases, Factual; Female; Gangrene; Humans; Male; Middle Aged; Peripheral Vascular Diseases; Propensity Score; Retrospective Studies; Risk Assessment; Risk Factors; alanine aminotransferase; albumin; aspartate aminotransferase; creatinine; epinephrine; noradrenalin; vasopressin; adult; age; amputation; anemia; article; Article; cerebrovascular disease; chi square test; comorbidity; confidence interval; controlled study; data source; diabetes mellitus; drug therapy; eosinophil; ethics; female; Fisher exact test; heart failure; hematocrit; high risk patient; human; hypercholesterolemia; hypertension; kidney disease; major clinical study; male; middle aged; monocyte; neutrophil; neutrophil lymphocyte ratio; observational study; odds ratio; peripheral vascular disease; propensity score; receiver operating characteristic; resuscitation; retrospective study; sensitivity and specificity; statistical analysis; Student t test; urea nitrogen blood level; aged; amputation; diagnosis; epidemiology; factual database; gangrene; procedures; risk assessment; risk factor | English | 2024 | 2024-05 | 10.1177/10225536241276892 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Letter | Reply Letter to the Editor regarding "Artificial intelligence- and computer-assisted navigation for shoulder surgery" | Lee, Kang-San; Jung, Seung Ho; Kim, Dong-Hyun; Chung, Seok Won; Yoon, Jong Pil | Kyungpook Natl Univ, Sch Med, Dept Orthopaed Surg, Daegu, South Korea; Konkuk Univ, Sch Med, Dept Orthopaed Surg, Med Ctr, Seoul, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Orthoped Surg, 130 Dongdeok ro, Daegu 41944, South Korea | 58967020700; 58967020800; 57198637188; 37065938600; 36098548400 | altjp1@gmail.com; | JOURNAL OF ORTHOPAEDIC SURGERY | J ORTHOP SURG-HONG K | 1022-5536 | 2309-4990 | 32 | 2 | SCIE | ORTHOPEDICS;SURGERY | 2024 | 1.6 | 49.8 | 0 | 2025-05-07 | 0 | 0 | Artificial Intelligence; Humans; Shoulder Joint; Surgery, Computer-Assisted; artificial intelligence; computer assisted surgery; human; Letter; shoulder surgery; systematic review; procedures; shoulder joint; surgery | English | 2024 | 2024-05 | 10.1177/10225536241263658 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||||
| ○ | ○ | Review | The potential of Municipal Solid Waste (MSW) layers as Anthropocene strata | For the Anthropocene to get recognized as a real geological era, first and foremost its strata must be identified. Several geological formations such as bogs, lakebeds, reefs, ice sheets, speleothems, river estuary deposits, and sea floors have been considered as potential candidates for the Anthropocene strata. This consideration arises from the emergence of novel materials associated with the Anthropocene, including radioactive isotopes, plastics, and aluminum, started to be discovered in their sediments and dramatically increased since the mid-20th century. Yet, these deposits are no longer considered 'natural' because human activities are largely controlling the transport and depositional processes from source to sink. The Municipal Solid Waste (MSW) in landfills has been also 'unnaturally' transported and deposited (landfilled) by humans. Since the 1950s, the controlled landfills have been made worldwide, and thus the opening time of the landfills is clear. The MSW layers of landfills, which appeared globally, contemporaneously, and with distinct characteristics, are indeed the 'artificial (anthropogenic)' strata showing a new and clear aspect of human influence, unprecedented in geological time. The MSW layers can be considered valuable indicators of the Anthropocene era because they not only preserve the history of human life but also sensitively demonstrate the scale of human activities like mass production, consumption, and disposal. The MSW layers can be expected to serve as a unique window into the Anthropocene. | Nahm, Wook-Hyun; Kim, Wonsuck; Kim, Minsik; Park, Buhm Soon; Han, Min; Kim, So-Jeong; Lim, Hyoun Soo; Choi, Junghae; Jun, Chang-Pyo | Korea Inst Geosci & Mineral Resources, Quaternary Res Ctr, Daejeon 34132, South Korea; Yonsei Univ, Dept Earth Syst Sci, Seoul 03722, South Korea; Korea Adv Inst Sci & Technol, Grad Sch Sci & Technol Policy, Daejeon 34141, South Korea; Korea Inst Geosci & Mineral Resources, Geoenvironm Res Ctr, Daejeon 34132, South Korea; Pusan Natl Univ, Dept Geol Sci, Busan 46241, South Korea; Kyungpook Natl Univ, Dept Earth Sci Educ, Daegu 41566, South Korea; Chonnam Natl Univ, Dept Sci Educ, Gwangju 61186, South Korea | Park, Buhm Soon/C-1681-2011; Kim, Minsik/MYS-2966-2025; Kim, Seong Cheol/ABD-1493-2022; Lim, Hyoun/AAC-5499-2022; Kim, Wonsuck/A-6751-2010 | 9334391900; 56054524500; 57747373300; 7402834875; 57194049439; 58958134300; 57226571916; 55839820300; 36655926700 | delta@yonsei.ac.kr; | EPISODES | EPISODES | 0705-3797 | 47 | 1 | SCIE | GEOSCIENCES, MULTIDISCIPLINARY | 2024 | 2.2 | 49.8 | 0 | 2025-04-16 | 0 | 0 | Anthropocene; landfill; municipal solid waste; sensitivity analysis; waste disposal; waste management | English | 2024 | 2024-03 | 10.18814/epiiugs/2023/02333 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Usefulness of cordless ultrasonic cutting energy devices in endoscopic nipple-sparing mastectomy: a retrospective study | Purpose: Endoscopic nipple -sparing mastectomy (E-NSM) is a minimally invasive surgical technique that shows good results in patients with breast cancer. The authors compared 3 different types of commercial energy devices to examine their efficacy and safety in E-NSM performed with breast reconstruction. Methods: A total of 36 cases of E-NSM were conducted with either Sonicision (S group, n = 11), Harmonic (H group, n = 6), or Thunderbeat (T group, n = 19). The clinicopathologic factors and postoperative complications, including nipple or skin necrosis and surgical site seroma volume, were evaluated for 3 months after surgery. Results: The surgical duration of E-NSM was significantly shorter in the S group than in the H group (P = 0.043) and T group (P = 0.037). However, the total surgical duration including E-NSM and breast reconstruction, and the total and daily drainage volume of postoperative seroma did not differ significantly among the 3 groups. Even when the energy devices were compared according to their working principle, i.e., ultrasonic (S and H) vs. hybrid (T), the total breast surgery duration and total and daily drainage volume of seroma showed no difference between the 2 groups. Although surgeon satisfaction did not significantly differ when using 3 devices for E-NSM (P = 0.428), surgeon's fatigue was found to be lowest in the S group, though it was not significant (P = 0.064). Conclusion: Any energy device can be safely used for E-NSM with breast reconstruction without causing any major complications. However, cordless ultrasonic energy devices allow greater mobility for the surgeon and, therefore, may shorten surgical time in breast surgery. | Kang, Byeongju; Keum, Heejung; Park, Ho Yong; Jung, Jin Hyang; Kim, Wan Wook; Lee, Jeeyeon | Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Surg, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Div Breast & Thyroid Surg, Dept Surg, 807 Hoguk Ro, Daegu 41404, South Korea | Lee, Jong-Mok/KVY-9550-2024; PARK, JUN-YOUNG/P-5981-2015 | 57279815300; 57221998716; 56564377200; 57209310173; 26023273400; 37079213100 | j.lee@knu.ac.kr; | ANNALS OF SURGICAL TREATMENT AND RESEARCH | ANN SURG TREAT RES | 2288-6575 | 2288-6796 | 106 | 3 | SCIE | SURGERY | 2024 | 1.6 | 49.8 | 2.11 | 2025-05-07 | 2 | 2 | Subcutaneous mastectomy; Surgical equipment; Wireless technology | Subcutaneous mastectomy; Surgical equipment; Wireless technology | English | 2024 | 2024-03 | 10.4174/astr.2024.106.3.147 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Concentration of docosahexsaenoic acid from tuna oil by a combination of solvent crystallization and lipase-catalyzed ethanolysis | The docosahexaenoic acid (DHA) was concentrated from tuna oil fatty acid using solvent crystallization combined with lipase-catalyzed ethanolysis. In the first step, solvent crystallization was carried out to concentrate DHA from tuna oil fatty acid using acetonitrile as a solvent. The optimal conditions of solvent crystallization were the crystallization temperature of -40 degrees C and the fatty acid to solvent ratio of 1:8 (w/v). This step increased the DHA content in the original tuna oil fatty acid from 22% up to 61%. In the second step, lipase-catalyzed ethanolysis was conducted with DHA-enriched fatty acid from the first step using Lipozyme RM IM (from Rhizomucor miehei) as a biocatalyst. The optimum conditions of this second step were the reaction temperature of 20 degrees C and the molar ratio of 1:1 (fatty acid to ethanol). Overall, DHA enrichment with purity of 85% was obtained by the two step processes. | Park, Mi Soon; Wee, Chido; Lee, Junsoo; Kim, Byung Hee; Kim, Hak-Ryul; Kim, In-Hwan | Korea Univ, Grad Sch, Dept Integrated Biomed & Life Sci, Transdisciplinary Major Learning Hlth Syst, Seoul, South Korea; Natl Inst Agr Sci, Dept Agrofood Resources, Wanju Gun, South Korea; Chungbuk Natl Univ, Dept Food Sci & Biotechnol, Cheongju, South Korea; Sookmyung Womens Univ, Dept Food & Nutr, Seoul, South Korea; Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu, South Korea; Korea Univ, Grad Sch, Dept Integrated Biomed & Life Sci, 145 Anam Ro, Seoul 02841, South Korea | 58843793700; 57305450800; 58844998900; 55542498400; 57191717289; 47161438300 | k610in@korea.ac.kr; | JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY | J AM OIL CHEM SOC | 0003-021X | 1558-9331 | 101 | 7 | SCIE | CHEMISTRY, APPLIED;FOOD SCIENCE & TECHNOLOGY | 2024 | 2.4 | 50.0 | 0.74 | 2025-05-07 | 2 | 2 | docosahexaenoic acid; enrichment; ethanolysis; lipase; Lipozyme RM IM; solvent crystallization | DOCOSAHEXAENOIC ACID; FATTY-ACIDS; FISH-OIL; SELECTIVE ESTERIFICATION; ENZYMATIC ESTERIFICATION; EICOSAPENTAENOIC ACID; STEARIDONIC ACID; ECHIUM OIL; ENRICHMENT; DHA | docosahexaenoic acid; enrichment; ethanolysis; lipase; Lipozyme RM IM; solvent crystallization | Catalysis; Molar ratio; Unsaturated fatty acids; Crystallization temperature; Docosahexaenoic acid; Enrichment; Ethanolysis; Lipase-catalyzed; Lipozyme RM IM; Oil fatty acids; Optimal conditions; Solvent crystallizations; Tuna oil; Organic solvents | English | 2024 | 2024-07 | 10.1002/aocs.12817 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article; Data Paper | Transcriptomic data of human adrenocortical NCI-H295R cells treated with cortisol biosynthesis inhibitors | Adrenal corticosteroid biosynthesis dysregulation can give rise to various pathological conditions, such as Cushing's syndrome, a disorder characterized by the sustained and excessive production of cortisol. Despite the development of several classes of steroidogenesis inhibitors to treat human diseases associated with cortisol overproduction, their use is limited by insufficient efficacy, adverse effects, and/or tolerability. Recently, we identified a series of benzimidazolylurea derivatives, including the representative compound CJ28, as novel cortisol biosynthesis inhibitors [1l . They significantly inhibited both basal and stimulated production of cortisol in NCI-H295R cells, a human adrenocarcinoma cell line. The inhibitory effects were attributed to both attenuated steroidogenesis and de novo cholesterol biosynthesis. Here, we provide transcriptomic (RNA-seq) data from adrenal cell cultures in response to treatment with either CJ28 or metyrapone (MET), an inhibitor of 11 beta-hydroxylase). Total RNA was extracted from the cells treated with vehicle (0.1% DMSO), CJ28 (30 mu M), or MET (30 mu M) for 24 h. Primary sequence data were acquired using paired-end sequencing on an Illumina NovaSeq 60 0 0 platform. The raw RNA-seq data have been deposited in the Gene Expression Omnibus (GEO) database (GSE236435). This dataset is a useful resource for providing valuable information on the gene expression networks underlying adrenocortical steroidogenesis.(c) 2023 Published by Elsevier Inc. This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0/ ) | Kim, Soo Hyun; Kim, Hyun Jung; Jung, Jong-Wha; Chung, Sooyoung; Son, Gi Hoon | Ewha Womans Univ, Scranton Coll, Dept Brain & Cognit Sci, Seoul 03760, South Korea; Korea Univ, Dept Biomed Sci, Coll Med, Seoul 02841, South Korea; Korea Univ, Coll Med, Dept Anat, Seoul 02841, South Korea; Kyungpook Natl Univ, Coll Pharm, Res Inst Pharmaceut Sci, Daegu 41566, South Korea; Korea Univ, Coll Med, Dept Legal Med, Seoul 02841, South Korea; Ewha Womans Univ, Scranton Coll, Dept Brain & Cognit Sci, Seoul 03760, South Korea; Korea Univ, Coll Med, Dept Biomed Sci, Seoul 02841, South Korea; Korea Univ, Coll Med, Dept Legal Med, Seoul 02841, South Korea | 김, 수중/JED-7162-2023; Kim, Soo-Hyun/D-1577-2019 | 58244723700; 57214681243; 26032128600; 7404292716; 7003374073 | csooy@ewha.ac.kr;songh@korea.ac.kr; | DATA IN BRIEF | DATA BRIEF | 2352-3409 | 52 | ESCI | MULTIDISCIPLINARY SCIENCES | 2024 | 1.4 | 50.0 | 0.81 | 2025-05-07 | 0 | 1 | Adrenal gland; NCI-H295R; Cortisol; Corticosteroid; Steroidogenesis; Benzimidazolylureas; Metyrapone | Adrenal gland; Benzimidazolylureas; Corticosteroid; Cortisol; Metyrapone; NCI-H295R; Steroidogenesis | Biochemistry; Biosynthesis; Drug products; Gene expression; RNA; Adrenal gland; Benzimidazolylurea; Biosynthesis inhibitors; Corticosteroid; H295r cells; Metyrapone; NCI-h295r; RNA-Seq datum; Steroidogenesis; Transcriptomics; Cortisol | English | 2024 | 2024-02 | 10.1016/j.dib.2023.109948 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Review | An Overview of the Cancer Targeting Attributes of the Elastin Like Polypeptide Nano-Carriers: Discerning Active and Passive Modes | Since the 1940s, generalized cytotoxic therapy has been a valuable tool in cancer treatment. Over the years, there's been a significant increase in developing potential cytotoxic drugs. However, little progress has been made in enhancing patients' quality of life. The therapeutic index is limited due to the drug's poor solubility and lack of selectivity. Various carriers have been explored for drug delivery to enhance efficacy. Yet, there's a gap for a versatile delivery system that can adjust to specific drug and application requirements. Here, a multifaceted drug delivery platform based on a genetically engineered nature-inspired polymer, elastin-like polypeptide (ELP) is introduced. This technology enables the customization of the polymeric vehicle's physicochemical characteristics to suit the needs of a specific drug and application. The review highlights ELP's advantages in cancer targeting, such as site-specificity, controlled release, biocompatibility, and extended plasma circulation. For the first time, ELP-based drug delivery into passive and active targeting for better comprehension of its adaptability is classified. Moreover, numerous opportunities for loading different types of drugs onto the polymer are outlined. Finally, the polymer's efficacy in delivery across multiple cancer types, underscoring the wide spectrum of ELP-based cancer drug delivery is precisely described. ELP technology represents a versatile platform with unique delivery attributes to facilitate selective delivery encompassing a range of potent therapeutics across multiple cancer models. image | Goel, Ridhima; Gulwani, Deepak; Upadhyay, Priyanka; Sarangthem, Vijaya; Singh, Thoudam Debraj | All India Inst Med Sci AIIMS, Dept Med Oncol Lab, New Delhi 110029, India; All India Inst Med Sci AIIMS, Dept Pathol, New Delhi 110029, India; Kyungpook Natl Univ, Cell & Matrix Res Inst, Sch Med, Dept Biochem & Cell Biol, Daegu 41944, South Korea | ; Sarangthem, Vijaya/AAX-7421-2020 | 57205099421; 58099926300; 57189309990; 56001741200; 55190689800 | devi1703@gmail.com;debraj.thoudam@gmail.com; | ADVANCED THERAPEUTICS | ADV THER-GERMANY | 2366-3987 | 7 | 12 | SCIE | PHARMACOLOGY & PHARMACY | 2024 | 2.6 | 50.1 | 0 | 2025-05-07 | 0 | 0 | active targeting; chemotherapeutic; drug delivery; elastin-like-polypeptide; passive targeting | CELL-PENETRATING PEPTIDES; THERMALLY RESPONSIVE POLYPEPTIDE; RECURSIVE DIRECTIONAL LIGATION; INVERSE TEMPERATURE TRANSITION; PROTEIN-BASED POLYMERS; DOXORUBICIN CONJUGATE; DRUG-DELIVERY; TUMOR ACCUMULATION; NANOPARTICLE FORMULATION; VASCULAR-PERMEABILITY | active targeting; chemotherapeutic; drug delivery; elastin-like-polypeptide; passive targeting | elastin-like polypeptide; polymer; biocompatibility; drug delivery system; human; malignant neoplasm; multiple cancer; polymerization; review; therapeutic index | English | 2024 | 2024-12 | 10.1002/adtp.202400332 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Evaluating the anticancer potential of Polygonum multiflorum root-derived stilbenes against H2452 malignant pleural mesothelioma cells | A naturally occurring stilbene, resveratrol, shows promising effects in the treatment of malignant pleural mesothelioma (MPM) both as a single agent and in combination with chemotherapeutic drugs. To discover new anticancer agents targeting MPM, stilbene-targeted isolation was performed on the roots of Polygonum multiflorum Thunb., an herbal medicine rich in stilbene compounds. In this study, seven stilbene glycosides (1-7) were isolated, along with four non-stilbenes (8-11), of which compounds 4 and 9-11 have not previously been isolated from this species. Stiquinoside A (1) is a previously undescribed stilbene glycoside, and its structure was elucidated as (E)-2,3,5,4 '-tetrahydroxystilbene 2-O-beta-D-quinovopyranoside based on 1D and 2D-NMR, HR-ESIMS, and acid hydrolysis experiments. Compounds 1, 4, 6, and 8 significantly inhibit the growth of MPM cancer cells H2452. These results demonstrate the potential utility of stilbenes in new strategies for the treatment of MPM. | Ngo, Trung Huy; Lee, Yoon-Jin; Choi, Hyukjae; Song, Kyung-Sik; Lee, Kyu Joon; Nam, Joo-Won | Yeungnam Univ, Coll Pharm, Gyongsan 38541, Gyeongsangbuk D, South Korea; Soonchunhyang Univ, Coll Med, Dept Biochem, Cheonan Si 31151, Chungcheongnam, South Korea; Yeungnam Univ, Res Inst Cell Culture, Gyongsan 38541, Gyeongsangbuk D, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, Daegu 41566, South Korea; Soonchunhyang Univ, Coll Med, Dept Trop Med, Cheonan Si 31151, Chungcheongnam, South Korea | Lee, Jeeyun/I-7171-2015 | 57847967800; 57205464171; 7404339587; 13310139000; 59231984200; 8883246800 | kjl07@sch.ac.kr;jwnam@yu.ac.kr; | FITOTERAPIA | FITOTERAPIA | 0367-326X | 1873-6971 | 177 | SCIE | CHEMISTRY, MEDICINAL;PHARMACOLOGY & PHARMACY | 2024 | 2.6 | 50.1 | 0.52 | 2025-05-07 | 3 | 3 | Polygonum multiflorum Thunb.; Polygonaceae; Stilbenes; Mesothelioma; H2452 | HETEROSIDES STEROIDES; TRITERPENIQUES; CONSTITUENTS; QUINOVOSIDES; GLUCOSIDES; GLYCOSIDES; CISPLATIN; DEATHS | H2452; Mesothelioma; Polygonaceae; Polygonum multiflorum Thunb.; Stilbenes | Antineoplastic Agents, Phytogenic; Cell Line, Tumor; China; Fallopia multiflora; Glycosides; Humans; Lung Neoplasms; Mesothelioma; Mesothelioma, Malignant; Molecular Structure; Phytochemicals; Plant Roots; Stilbenes; antineoplastic agent; cisplatin; emodin; plant extract; Polygonum multiflorum extract; resveratrol; stilbene derivative; unclassified drug; antineoplastic agent; glycoside; phytochemical; stilbene derivative; acid hydrolysis; antineoplastic activity; Article; cell viability; chemical structure; controlled study; Fallopia multiflora; flow rate; herbal medicine; heteronuclear multiple bond correlation; high performance liquid chromatography; human; human cell; MTT assay; NCI-H2452 cell line; nonhuman; plant root; pleura mesothelioma; chemistry; China; drug therapy; isolation and purification; lung tumor; malignant mesothelioma; mesothelioma; tumor cell line | English | 2024 | 2024-09 | 10.1016/j.fitote.2024.106135 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Heterogeneity of gut microbiome compositions in the third decade of life in Japanese women: insights from a comparative analysis | The reasons for sex-associated gut microbiota differences have not been determined, and although sex hormones, diet, and other factors are considered to contribute to them, many of these factors are age related. To shed light on this complex interplay, our study aimed to investigate and compare the gut microbial compositions of males and females across a broad range of ages, aiming to identify sex-associated disparities and potential causal factors. Our study encompassed a comprehensive analysis of gut microbiota data obtained from 444 Japanese individuals, ranging from newborns to centenarians, sourced from the DNA Data Bank of Japan. We categorized the subjects into 13 distinct age groups and examined their relative microbial abundances, as well as alpha and beta diversities, in relation to sex and age. No difference was observed between gut microbiota relative abundances or alpha diversities between men and women at any age. However, the study showed that the heterogeneity of gut microbiota among women in their 20s was greater than in men. To confirm the general occurrence of this difference, we conducted additional analyses using seven datasets: three from Japan and four from other countries. Interestingly, this variance was particularly noticeable within Japanese women. We also showed a potential link between the observed heterogeneity and dietary fiber intake. It is hoped this study will provide clues that aid in the identification of factors responsible for sex-associated differences in gut microbiota compositions. | Le, Tan Minh; Nguyen, Hong Duc Thi; Lee, Olive E. M.; Lee, Donghyeon; Choi, Yeseul; Chong, Gun Oh; Cho, Junghwan; Park, Nora Jee-Young; Han, Hyung Soo; Seo, Incheol | Kyungpook Natl Univ, Grad Sch, Dept Biomed Sci, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, BK21 Four Program, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Clin Omics Inst, Daegu 41405, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Obstet & Gynecol, Daegu 41404, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Pathol, Daegu 41404, South Korea; Kyungpook Natl Univ, Sch Med, Dept Physiol, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Immunol, 680 Gukchaebosang Ro, Daegu 41944, South Korea | Cho, Junghwan/AAK-4752-2020 | 57870749600; 57870555300; 58029901300; 57870503500; 57226123444; 23099068000; 57424663500; 57226185359; 7401969388; 56022683900 | iseo@knu.ac.kr; | BIOSCIENCE OF MICROBIOTA FOOD AND HEALTH | BIOSCI MICROB FOOD H | 2186-6953 | 2186-3342 | 43 | 1 | SCIE | MICROBIOLOGY;NUTRITION & DIETETICS | 2024 | 2.9 | 50.4 | 0.6 | 2025-04-16 | 0 | 1 | human gut microbiota; sex difference; dietary fiber | DIETARY FIBER; AGE; DATABASE; GENDER; HEALTH; IMPACT; SILVA | dietary fiber; human gut microbiota; sex difference | English | 2024 | 2024 | 10.12938/bmfh.2023-043 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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