연구성과로 돌아가기
2020 연구성과 (198 / 270)
※ 컨트롤 + 클릭으로 열별 다중 정렬 가능합니다.
Excel 다운로드
| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ○ | ○ | Article | An easy way to tidy up long hair with rubber bands during scalp surgery | One of the most challenging steps in preparing for dermatologic operations on the scalp can be securing a clean surgical field without long and messy hair. We present a simple and painless way to remove hair from the scalp surgical field utilizing three rubber bands. | Lee, Eun Hye; Kim, Jun Young | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Dept Dermatol, Sch Med, Daegu, South Korea | 57189661699; 35310922800 | 198kjy@hanmail.net; | PEDIATRIC DERMATOLOGY | PEDIATR DERMATOL | 0736-8046 | 1525-1470 | 37 | 6 | SCIE | DERMATOLOGY;PEDIATRICS | 2020 | 1.588 | 74.0 | 0 | 2025-06-25 | 1 | 1 | hair; rubber band; scalp; surgery | HEAD; DRAPE | hair; rubber band; scalp; surgery | Hair; Humans; Scalp; rubber; Article; child; hair; human; pediatric surgeon; priority journal; scalp; scalp surgery; skin surgery; surgery | English | 2020 | 2020-11 | 10.1111/pde.14382 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Hepatoprotective effects of vicenin-2 and scolymoside through the modulation of inflammatory pathways | The aim of this study was to investigate the effects of two structurally related flavonoids found in Cyclopia subternata, vicenin-2 (VCN) and scolymoside (SCL) on lipopolysaccharide (LPS)-induced liver failure in mice and to elucidate underlying mechanisms. Mice were treated intravenously with VCN or SCL at 12 h after LPS treatment. LPS significantly increased mortality, serum levels of alanine transaminase, aspartate transaminase, and inflammatory cytokines, and toll-like receptor 4 (TLR4) protein expression; these effects of LPS were inhibited by VCN or SCL. It also attenuated the LPS-induced activation of myeloid differentiation primary response gene 88 and TLR-associated activator of interferon-dependent signaling pathways of the TLR system. Our results suggest that VCN or SCL protects against LPS-induced liver damage by inhibiting the TLR-mediated inflammatory pathway, indicating its potential to treat liver diseases. | Lee, In-Chul; Bae, Jong-Sup | Seowon Univ, Dept Cosmet Sci & Technol, Cheongju 28674, South Korea; Kyungpook Natl Univ, BK21 Plus KNU Multiom Based Creat Drug Res Team, Res Inst Pharmaceut Sci, Coll Pharm,CMRI, 80 Dahak Ro, Daegu 41566, South Korea | Bae, Jong-Sup/AAU-9724-2020 | 56390536600; 16021543200 | baejs@knu.ac.kr; | JOURNAL OF NATURAL MEDICINES | J NAT MED-TOKYO | 1340-3443 | 1861-0293 | 74 | 1 | SCIE | CHEMISTRY, MEDICINAL;PHARMACOLOGY & PHARMACY | 2020 | 2.343 | 74.1 | 0.83 | 2025-06-25 | 17 | 17 | Vicenin-2; Scolymoside; Lipopolysaccharide; Liver failure; Toll-like receptor | NECROSIS-FACTOR-ALPHA; TOLL-LIKE RECEPTORS; IN-VITRO; HEPATIC-INJURY; LUNG INJURY; MANGIFERIN; ACTIVATION; COMPONENTS; HONEYBUSH; FAILURE | Lipopolysaccharide; Liver failure; Scolymoside; Toll-like receptor; Vicenin-2 | Animals; Apigenin; Glucosides; Inflammation; Lipopolysaccharides; Luteolin; Male; Mice; Signal Transduction; alanine aminotransferase; aspartate aminotransferase; cytokine; flavonoid; lipopolysaccharide; myeloid differentiation factor 88; scolymoside; toll like receptor 4; unclassified drug; vicenin 2; apigenin; apigenin-6,8-di-C-glycopyranoside; glucoside; lipopolysaccharide; luteolin; scolymoside; alanine aminotransferase blood level; animal cell; animal experiment; animal model; animal tissue; antiinflammatory activity; Article; aspartate aminotransferase blood level; controlled study; Cyclopia (genus); Cyclopia subternata; drug structure; liver failure; liver protection; male; molecular mechanics; mortality; mouse; nonhuman; protein expression; signal transduction; structure analysis; animal; chemistry; inflammation | English | 2020 | 2020-01 | 10.1007/s11418-019-01348-x | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Li2MoO4Phonon-Scintillation Detection Systems with MMC Readout | We developed measurement systems for the simultaneous detection of phonon and scintillation signals from Li2MoO4 crystals based on the metallic magnetic calorimeter (MMC) technology. Two measurements were carried out using Li2MoO4 crystals of different sizes. The first measurement was conducted with a compact detection system designed for a 1x1x1cm3 crystal. An advanced light detector with Neganov-Luke phonon amplification was adopted in the compact setup. Later, the second experiment was carried out using a cylindrical Li2MoO4 crystal of 5 cm in diameter and 5 cm in height. Another light detector was implemented with a 2-in. Ge wafer and an MMC sensor. Both measurements resulted in simultaneous detection of heat and light signals. Clear particle discriminations between alpha- and beta/gamma-induced events were demonstrated by comparing amplitudes of the heat and light signals in both measurements. The heat signals in the larger setup showed an energy resolution of 18 keV FWHM for 2615 keV gamma-rays. The energy linearity of the detector response was investigated for a suitable calibration near 3.034 MeV, the Q value of 100Mo double-beta decay. | Kim, H. L.; Kim, H. J.; Kim, I; Kim, S. R.; Kim, Y. D.; Kim, Y. H.; Kwon, D. H.; Jeon, J. A.; Lee, M. H.; Lee, M. K.; So, J. H. | Inst Basic Sci IBS, Ctr Underground Phys, Daejeon 34126, South Korea; Kyungpook Natl Univ, Dept Phys, Daegu 41566, South Korea; Korea Res Inst Stand & Sci, Daejeon 34113, South Korea; Univ Sci & Technol, Daejeon 34113, South Korea | Lee, Jinwoo/P-2493-2018; Kim, Hong Joo/AAE-1178-2022; Lee, You/T-6086-2019; Lee, Moo/AAK-4266-2020; Kim, Inwook/AAI-5234-2020 | 57218825747; 59051568100; 55477709100; 56401942100; 7410207253; 57196171764; 57201795741; 24478376500; 57198252980; 7409120947; 35277558300 | kh17984@gmail.com;yhk@ibs.re.kr; | JOURNAL OF LOW TEMPERATURE PHYSICS | J LOW TEMP PHYS | 0022-2291 | 1573-7357 | 199 | 3-4 | SCIE | PHYSICS, APPLIED;PHYSICS, CONDENSED MATTER | 2020 | 1.57 | 74.1 | 0.69 | 2025-06-25 | 10 | 10 | Low temperature detectors; Phonon-scintillation detection; Neutrinoless double-beta decay; Metallic magnetic calorimeter | DOUBLE-BETA DECAY; LIGHT DETECTION; CRYSTAL; HEAT | Low temperature detectors; Metallic magnetic calorimeter; Neutrinoless double-beta decay; Phonon–scintillation detection | Calorimeters; Gamma rays; Lithium compounds; Phonons; Photodetectors; Scintillation; Temperature; Low temperature detector; Metallic magnetic calorimeters; Neutrinoless double-beta decays; Phonon amplification; Scintillation detection; Scintillation detection systems; Scintillation signals; Simultaneous detection; Signal detection | English | 2020 | 2020-05 | 10.1007/s10909-019-02291-7 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Stabilization Heaters for Low-Temperature Thermal Calorimeters | Signal amplitudes of low-temperature detectors, vastly used in rare-event searches such as neutrinoless double beta decay experiments, are sensitive to measurement conditions causing instability such as operation temperature fluctuations. Those detector signal amplitudes thus present drifts and shifts over time due to those temperature fluctuations and need to be corrected. This effect degrades the energy resolution and particle discrimination capabilities of the calorimetric detection at low temperatures, with both strongly affecting the sensitivity of rare-event search experiments. Joule heaters were developed and used on absorber crystals in the Advanced Mo-based Rare process Experiment project, to inject periodically a controlled amount of heat, and thus produce reference signals that can be used to correct and thus stabilize the signal amplitudes of the detectors. The pulse height of the heater signals could not be used as a correction parameter as it was affected by various sources of instability. Instead, the rise time of the heater signals was used to generate a correction function describing well the time dependence of the particle-induced events in the crystals and thus provided a significant improvement of the energy resolution and particle discrimination capabilities to separate beta/gamma and alpha events. | Kwon, D. H.; Jeon, J. A.; Jo, H. S.; Kim, H. B.; Kim, H. L.; Kim, I.; Kim, S. R.; Kim, Y. H.; Lee, H. J.; Lee, M. K.; Lee, Y. C.; Woo, K. R. | Inst for Basic Sci Korea, Ctr Underground Phys, Daejeon 34126, South Korea; UST, Daejeon 34113, South Korea; Kyungpook Natl Univ, Dept Phys, Daegu 41566, South Korea; KRISS, Daejeon 34113, South Korea | Lee, Jong/A-3198-2011; Kim, Hong Joo/AAE-1178-2022; Kim, Inwook/AAI-5234-2020; Lee, Yong Jae/GLR-4153-2022; Jo, Hyon-Suk/HGC-7070-2022; Lee, You/T-6086-2019; Lee, Jinwoo/P-2493-2018 | 57201795741; 24478376500; 35227429400; 57191717302; 57218825747; 55477709100; 56401942100; 57196171764; 57225012168; 7409120947; 57203244766; 57211276680 | hyonsuk@knu.ac.kr;yhk@ibs.re.kr; | JOURNAL OF LOW TEMPERATURE PHYSICS | J LOW TEMP PHYS | 0022-2291 | 1573-7357 | 200 | 5-6 | SCIE | PHYSICS, APPLIED;PHYSICS, CONDENSED MATTER | 2020 | 1.57 | 74.1 | 0.15 | 2025-06-25 | 4 | 4 | Neutrinoless double beta decay; Drift correction; Metallic magnetic calorimeter | Drift correction; Metallic magnetic calorimeter; Neutrinoless double beta decay | Crystals; Temperature distribution; Correction function; Energy resolutions; Low temperature detector; Measurement conditions; Neutrinoless double-beta decays; Operation temperature; Reference signals; Temperature fluctuation; Signal detection | English | 2020 | 2020-09 | 10.1007/s10909-020-02432-3 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Suppressive functions of collismycin C in TGFBIp-mediated septic responses | Transforming growth factor beta-induced protein (TGFBIp) is an extracellular matrix protein; its expression by several cell types is greatly increased by TGF-beta. TGFBIp is released by primary human umbilical vein endothelial cells (HUVECs) and functions as a mediator of experimental sepsis. 2,2 '-Bipyridine-containing natural products are generally accepted to have antimicrobial, cytotoxic and anti-inflammatory properties. We hypothesized that a 2,2 '-bipyridine containing natural product, collismycin C, could reduce TGFBIp-mediated severe inflammatory responses in human endothelial cells and mice. Here we investigated the effects and underlying mechanisms of collismycin C against TGFBIp-mediated septic responses. Collismycin C effectively inhibited lipopolysaccharide-induced release of TGFBIp and suppressed TGFBIp-mediated septic responses. In addition, collismycin C suppressed TGFBIp-induced sepsis lethality and pulmonary injury. This suppression of TGFBIp-mediated and CLP-induced septic responses indicates that collismycin C is a potential therapeutic agent for various severe vascular inflammatory diseases, with inhibition of the TGFBIp signaling pathway as the mechanism of action. | Lee, Bong-Seon; Kim, Eonmi; Choi, Hyukjae; Bae, Jong-Sup | Kyungpook Natl Univ, Res Inst Pharmaceut Sci, BK21 Plus KNU Multi Based Creat Drug Res Team, Coll Pharm,CMRI, 80 Dahak Ro, Daegu 41566, South Korea; Yeungnam Univ, Coll Pharm, 280 Daehak Ro, Gyongsan 38541, Gyeongbuk, South Korea | Bae, Jong-Sup/AAU-9724-2020 | 57204178543; 57199802851; 7404339587; 16021543200 | h5choi@yu.ac.kr;baejs@knu.ac.kr; | JOURNAL OF NATURAL MEDICINES | J NAT MED-TOKYO | 1340-3443 | 1861-0293 | 74 | 2 | SCIE | CHEMISTRY, MEDICINAL;PHARMACOLOGY & PHARMACY | 2020 | 2.343 | 74.1 | 0.13 | 2025-06-25 | 3 | 3 | Collismycin C; Tgfbip; Sepsis; Severe inflammation; HUVEC | MATRIX PROTEIN BETA-IG-H3; SMOOTH-MUSCLE-CELLS; GROWTH; LIPOPOLYSACCHARIDE; CAERULOMYCIN; ADHESION; SEPSIS; GENE; PYRISULFOXIN; EXPRESSION | Collismycin C; HUVEC; Sepsis; Severe inflammation; Tgfbip | 2,2'-Dipyridyl; Animals; Anti-Inflammatory Agents; Extracellular Matrix Proteins; Humans; Inflammation; Mice; Mice, Inbred C57BL; Sepsis; Transforming Growth Factor beta; 2,2' bipyridine; beta5 integrin; cell adhesion molecule; collismycin C; dabrafenib; lipopolysaccharide; messenger RNA; microbial products not classified elsewhere; mitogen activated protein kinase; scleroprotein; transforming growth factor beta induced protein; unclassified drug; 2,2' bipyridine; antiinflammatory agent; betaIG-H3 protein; collismycin C; scleroprotein; transforming growth factor beta; animal cell; animal experiment; animal model; animal tissue; antiinflammatory activity; antimicrobial activity; Article; C57BL 6 mouse; cecal ligation and puncture-induced sepsis; controlled study; drug effect; drug mechanism; human; human cell; HUVEC cell line; in vitro study; in vivo study; inflammation; lethality; leukocyte adherence; leukocyte migration; lung injury; male; mouse; neutrophil; nonhuman; protein expression; protein secretion; TGF beta signaling; animal; C57BL mouse; inflammation; sepsis | English | 2020 | 2020-03 | 10.1007/s11418-019-01374-9 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | A checklist of freshwater algae from Mt. Sinbul alpine wetlands in South Korea | The present study summarized the freshwater algal diversity from Mt. Sinbul alpine wetlands in South Korea from March 2013 to December 2019. We identified a total of 183 taxa belong to seven main algal groups (Charophyta, Chlorophyta, Cyanophyta, Chrysophyta, Cryptophyta, Dinophyta and Euglenophyta). The algal communities were characterized by high species numbers of the desmids making up 108 taxa. It was examined that the number of species was higher during late spring and summer. Among them, a total of 53 taxa of 40 desmid species (Charophyta) including 4 new taxa (Actinotaenium crassiusculum var. minutum var. nov., Cosmarium vitiosum var. koreanum var. nov., Groenbladia neglecta var. longa var. nov., Staurodesmus koreanus sp. nov.), 5 species of Chlorophyta, 7 species of Chrysophyta and 1 species of Cyanophyta have been recorded for the first time in Korea. | Kim, Han Soon; Lee, Jae Hak; Kim, Jin Hee | Kyungpook Natl Univ, Dept Biol, Daegu 41566, South Korea; Natl Inst Biol Resources, Incheon 22689, South Korea | Lee, Joonseok/AFQ-8078-2022; Kim, Jin/AET-7817-2022 | 7410135359; 55690077600; 55720319100 | kimhsu@knu.ac.kr; | NOVA HEDWIGIA | NOVA HEDWIGIA | 0029-5035 | 2363-7188 | 111 | 1-2 | SCIE | PLANT SCIENCES | 2020 | 1.135 | 74.3 | 0.31 | 2025-06-25 | 2 | 3 | Desmids; Freshwater algal; Mt. Sinbul alpine wetlands; New taxa | GREEN-ALGAE; DESMIDS; RECORDS | Desmids; Freshwater algal; Mt. Sinbul alpine wetlands; New taxa | English | 2020 | 2020-08 | 10.1127/nova_hedwigia/2020/0584 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | A Simple and Efficient System for Producing Recombinant Human CXCL8 inEscherichia coli | Multifunctional pro-inflammatory cytokine CXCL8 is a small peptide of 8-10 kDa in size and it functions as a monomer or dimer. CXCL8 harbors 2 disulfide bonds for its stability. Although production of the CXCL8 protein in a large quantity in both mammalian and bacterial systems has been reported, the processes are complicated and lengthy. Here, we develop a new bacterial expression system for recombinant CXCL8 and simplify the purification system to yield a high amount of protein quickly. The purified CXCL8 protein from our new system develops a crystal structure that is identical to that produced through the mammalian expression system. Thus, we have established a simple and efficient recombinant CXCL8-producing system, which can be easily operated and is suitable to those requiring a large quantity of CXCL8. | Huang, Changhao; Zhong, Shangwei; Park, HaJeung; Jeong, Ji-Hak; Luo, Jun-Li | Scripps Res Inst, Dept Mol Med, Jupiter, FL USA; Scripps Res Inst, Xray Core Facil, Jupiter, FL USA; Kyungpook Natl Univ, Pharmaceut Sci Res Inst, Coll Pharm, 80 Daehak Ro, Daegu 41566, South Korea | 57190050818; 55639445400; 7601570080; 55913671500; 26327010000 | jihakjeong@gmail.com;jlluo@scripps.edu; | JOURNAL OF INTERFERON AND CYTOKINE RESEARCH | J INTERF CYTOK RES | 1079-9907 | 1557-7465 | 40 | 9 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CELL BIOLOGY;IMMUNOLOGY | 2020 | 2.607 | 74.4 | 0.11 | 2025-06-25 | 2 | 2 | CXCL8; secreted protein; inflammatory mediator; crystal structure; protein expression; protein purification | HUMAN INTERLEUKIN-8; CRYSTAL-STRUCTURE; PURIFICATION; EXPRESSION; ANTIBODY; PROTEIN | crystal structure; CXCL8; inflammatory mediator; protein expression; protein purification; secreted protein | Escherichia coli; Humans; Interleukin-8; Models, Molecular; Protein Multimerization; Protein Stability; Recombinant Proteins; Structure-Activity Relationship; recombinant interleukin 8; CXCL8 protein, human; interleukin 8; recombinant protein; Article; cell proliferation assay; controlled study; crystal structure; crystallization; disulfide bond; Escherichia coli; gene expression system; human; human cell; liquid chromatography; molecular cloning; nonhuman; priority journal; protein expression; protein purification; biosynthesis; chemistry; Escherichia coli; genetics; isolation and purification; metabolism; molecular model; protein multimerization; protein stability; structure activity relation | English | 2020 | 2020-09-01 | 10.1089/jir.2020.0021 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Osborn waves during therapeutic hypothermia and recurrence of fatal arrhythmia in patients resuscitated following sudden cardiac arrest | Background This study investigates the impact of the occurrence of Osborn waves during therapeutic hypothermia (TH) on the recurrence of future fatal arrhythmias in patients resuscitated after sudden cardiac arrest (SCA). Methods Of all survivors of out-of-hospital SCA, 100 consecutive patients (mean age, 52 +/- 15 years; 80% men) who received TH were included in this study. Results The most common first documented arrhythmia was ventricular fibrillation (VF) (77%), and ischemic heart disease (44%) and idiopathic VF (22%) were the most common causes of SCA in resuscitated patients. During TH, Osborn waves developed in 29 patients (29%). Osborn waves occurred more frequently in patients with Brugada syndrome. Patients with Osborn waves had lower in-hospital (10.3% vs 26.8%;P = .072) and 1-year death rates (20.7% vs 39.4%;P = .073) and better cerebral function (cerebral performance category scale, 2.0 +/- 1.5 vs 2.7 +/- 1.8;P = .053) than those without Osborn waves, although there was no statistical significance. Among 78 in-hospital survivors, 31 (40%) underwent implantable cardioverter-defibrillator (ICD) implantation. Appropriate ICD shocks from fatal arrhythmias were more frequent in patients who had Osborn waves than in those without Osborn waves (43% vs 6%;P = .032). Conclusions Osborn waves during TH had no significant effect on the survival and cerebral function of patients resuscitated SCA. However, appropriate ICD shocks due to the recurrence of VF were more frequent in patients with Osborn waves during long-term follow-up. | Park, Yoon Jung; Bae, Myung Hwan; Kim, Hyeon Jeong; Park, Bo Eun; Kim, Hong Nyun; Jang, Se Yong; Lee, Jang Hoon; Yang, Dong Heon; Park, Hun Sik; Cho, Yongkeun; Chae, Shung Chull | Kyungpook Natl Univ, Sch Med, Dept Internal Med, Div Cardiol, 130 Dongdeok Ro, Daegu 41944, South Korea | Park, Hang-soo/AEH-1640-2022 | 57216539556; 36607356800; 57204359002; 57201131446; 56706769800; 57207977889; 54581258000; 35277423400; 57198844106; 9249593500; 7101962036 | bmh0325@knu.ac.kr; | PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY | PACE | 0147-8389 | 1540-8159 | 43 | 11 | SCIE | CARDIAC & CARDIOVASCULAR SYSTEMS;ENGINEERING, BIOMEDICAL | 2020 | 1.976 | 74.7 | 0.17 | 2025-06-25 | 2 | 3 | cardiac arrest; dynamic electrocardiography; hypothermia; ventricular fibrillation | VENTRICULAR-FIBRILLATION; COMATOSE SURVIVORS; ELECTROCARDIOGRAM; ELEVATION; MODEL | cardiac arrest; dynamic electrocardiography; hypothermia; ventricular fibrillation | Adult; Arrhythmias, Cardiac; Echocardiography; Electrocardiography; Female; Humans; Hypothermia, Induced; Male; Middle Aged; Out-of-Hospital Cardiac Arrest; Recurrence; adult; Article; brain function; Brugada syndrome; controlled study; disease course; electrocardiogram; female; follow up; heart arrhythmia; heart ventricle fibrillation; hospital mortality; human; induced hypothermia; ischemic heart disease; major clinical study; male; middle aged; mortality rate; osborn wave; resuscitation; sudden cardiac death; survivor; treatment outcome; echocardiography; electrocardiography; heart arrhythmia; mortality; out of hospital cardiac arrest; pathophysiology; recurrent disease | English | 2020 | 2020-11 | 10.1111/pace.14070 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Emotional Video to Audio Transformation Using Deep Recurrent Neural Networks and a Neuro-Fuzzy System | Generating music with emotion similar to that of an input video is a very relevant issue nowadays. Video content creators and automatic movie directors benefit from maintaining their viewers engaged, which can be facilitated by producing novel material eliciting stronger emotions in them. Moreover, there is currently a demand for more empathetic computers to aid humans in applications such as augmenting the perception ability of visually- and/or hearing-impaired people. Current approaches overlook the video's emotional characteristics in the music generation step, only consider static images instead of videos, are unable to generate novel music, and require a high level of human effort and skills. In this study, we propose a novel hybrid deep neural network that uses an Adaptive Neuro-Fuzzy Inference System to predict a video's emotion from its visual features and a deep Long Short-Term Memory Recurrent Neural Network to generate its corresponding audio signals with similar emotional inkling. The former is able to appropriately model emotions due to its fuzzy properties, and the latter is able to model data with dynamic time properties well due to the availability of the previous hidden state information. The novelty of our proposed method lies in the extraction of visual emotional features in order to transform them into audio signals with corresponding emotional aspects for users. Quantitative experiments show low mean absolute errors of 0.217 and 0.255 in the Lindsey and DEAP datasets, respectively, and similar global features in the spectrograms. This indicates that our model is able to appropriately perform domain transformation between visual and audio features. Based on experimental results, our model can effectively generate an audio that matches the scene eliciting a similar emotion from the viewer in both datasets, and music generated by our model is also chosen more often (code available online at ). | Sergio, Gwenaelle Cunha; Lee, Minho | Kyungpook Natl Univ, Sch Elect Engn, Daegu 41566, South Korea | Lee, Min-Ho/ABE-5735-2021 | 57188756097; 57191730119 | gwena.cs@gmail.com;mholee@gmail.com; | MATHEMATICAL PROBLEMS IN ENGINEERING | MATH PROBL ENG | 1024-123X | 1563-5147 | 2020 | SCIE | ENGINEERING, MULTIDISCIPLINARY;MATHEMATICS, INTERDISCIPLINARY APPLICATIONS | 2020 | 1.305 | 75.0 | 0.67 | 2025-06-25 | 5 | 8 | EVOLUTION; BIOLOGY; BRAIN; ART | Audio acoustics; Audition; Deep neural networks; Fuzzy neural networks; Fuzzy systems; Recurrent neural networks; Adaptive neuro-fuzzy inference system; Domain transformation; Emotional aspect; Hearing impaired; Mean absolute error; Modeling emotions; Neurofuzzy system; Quantitative experiments; Fuzzy inference | English | 2020 | 2020-02-24 | 10.1155/2020/8478527 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Anti-inflammatory effect of hispidin on LPS induced macrophage inflammation through MAPK and JAK1/STAT3 signaling pathways | Severe inflammatory reactions caused by macrophage activation can trigger a systemic immune response. In the present study, we observed the anti-inflammatory properties of hispidin on LPS induced RAW264.7 macrophage cells. Our results showed that hispidin treatment significantly reduced the production of cellular NO, IL-6 and reactive oxygen species (ROS) while has not inhibitory effect on TNF-alpha productions. Excitingly, hispidin treatment retains the phagocytosis ability of macrophages which enabling them to perform the function of removing foreign invaders. Signaling studies showed, hispidin treatment dramatic suppressed the LPS induced mitogen activated protein kinases (MAPK) and JAK/STAT activations. In conclusion, our findings suggest that hispidin may be a new therapeutic target for clinical treatment of macrophages-mediated inflammatory responses. | Han, Ying-Hao; Chen, Dong-Qin; Jin, Mei-Hua; Jin, Ying-Hua; Li, Jing; Shen, Gui-Nan; Li, Wei-Long; Gong, Yi-Xi; Mao, Ying-Ying; Xie, Dan-Ping; Lee, Dong-Seok; Yu, Li-Yun; Kim, Sun-Uk; Kim, Ji-Su; Kwon, Taeho; Cui, Yu-Dong; Sun, Hu-Nan | Heilongjiang Bayi Agr Univ, Coll Life Sci & Biotechnol, Daqing 163319, Peoples R China; Heilongjiang Bayi Agr Univ, Lib & Informat Ctr, Daqing 163319, Peoples R China; Kyungpook Natl Univ, Coll Nat Sci, KNU Ctr Nonlinear Dynam, CMRI,Sch Life Sci,BK21 Plus KNU Creat BioRes Grp, Daegu 41566, South Korea; Korea Res Inst Biosci & Biotechnol KRIBB, Futurist Anim Resource & Res Ctr, Cheongju 28116, Chungcheongbuk, South Korea; Korea Res Inst Biosci & Biotechnol KRIBB, Primate Resources Ctr, Jeongeup Si 56216, Jeonbuk, South Korea | Kim, Sunuk/KJM-5211-2024; Kwon, Taeho/JLL-1095-2023; Jin, Meihua/AAE-8526-2020 | 7404096642; 57216656930; 57740660100; 8610761600; 57196156702; 36193289800; 57216653885; 57209617864; 57216651176; 57209616350; 57210068061; 8604011000; 8278891100; 39461534900; 57202850676; 24342913900; 8603267900 | kwon@kribb.re.kr;cuiyudong@126.com;sunhunan76@163.com; | APPLIED BIOLOGICAL CHEMISTRY | APPL BIOL CHEM | 2468-0834 | 2468-0842 | 63 | 1 | SCIE | FOOD SCIENCE & TECHNOLOGY | 2020 | 1.813 | 75.2 | 0.68 | 2025-06-25 | 17 | 18 | Hispidin; LPS; Macrophage; ROS; Signal transduction | NF-KAPPA-B; JAK-STAT; P38 MAPK; CYTOKINE PRODUCTION; MEDICINAL MUSHROOM; IL-6 PRODUCTION; IFN-GAMMA; TNF-ALPHA; CELLS; EXPRESSION | Hispidin; LPS; Macrophage; ROS; Signal transduction | Antigen-antibody reactions; Chemical activation; Signal transduction; Anti-inflammatories; Anti-inflammatory effects; Hispidin; Immune response; Inflammatory reaction; LPS; Macrophage activation; Mitogen-activated protein kinase; Reactive oxygen species; Signalling pathways; Macrophages | English | 2020 | 2020-05-04 | 10.1186/s13765-020-00504-2 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Anti-inflammatory effect of unripe apple polyphenols-chitooligosaccharides microcapsule against LPS-induced RAW 264.7 cells | In order to improve the synergistic effect of unripe apple polyphenols (APP) and chitooligosaccharides (COS), apple polyphenols-chitooligosaccharides microcapsule (APCM) were prepared by spray-drying method. The effects of APCM on the release of polyphenols in simulated gastrointestinal digestion model, as well as the anti-inflammatory effect against LPS-induced RAW264.7 cells were also evaluated. Scanning electron microscope (SEM) and HPLC analysis of APP and APCM showed that during the spray-drying process, most of the polyphenols are successfully encapsulated in COS. The simulated gastrointestinal digestion model results showed that about 98% of polyphenols released from APCM within 60 min. Anti-inflammatory effect of APCM on LPS induced RAW 264.7 cells showed that although APP showed a strong inhibitory effect on cell viability at 0.6 mg/mL, the effect of APCM on cell viability was less and could maintain a high level at the same concentration. In addition, APCM significantly inhibited nitric oxide (NO) and TNF-alpha production via the elevation of cytokine IL-10 as the concentration increases, respectively. The results suggest that APCM alleviate the intensity of inflammatory processes by inhibiting the production of pro-inflammatory cytokines TNF-alpha, as well as additionally by promoting the production of anti-inflammatory cytokines IL-10. These findings provide scientific and theoretical support for the claim that traditional medicine treats inflammation-related diseases. | Zheng, Hu-Zhe; Cui, Chun-Lan; Jeong, Woo-Sik; Chung, Shin-Kyo | Jiangsu Food & Pharmaceut Sci Coll, Dept Hlth Sci, Huaian 223003, Peoples R China; Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea | Jeong, Woo-Sik/AAN-6885-2020 | 35217210000; 55898464400; 10440750200; 7404292790 | 2547758626@qq.com; | APPLIED BIOLOGICAL CHEMISTRY | APPL BIOL CHEM | 2468-0834 | 2468-0842 | 63 | 1 | SCIE | FOOD SCIENCE & TECHNOLOGY | 2020 | 1.813 | 75.2 | 0.43 | 2025-06-25 | 12 | 12 | Apple polyphenols-chitooligosaccharides microcapsule; Simulated gastrointestinal digestion model; Cell viability; Nitric oxide; TNF-alpha; IL-10; RAW 264.7 cells | CHITOSAN; ANTIOXIDANT; INFLAMMATION; CONJUGATION; SUPPRESSION | Apple polyphenols-chitooligosaccharides microcapsule; Cell viability; IL-10; Nitric oxide; RAW 264.7 cells; Simulated gastrointestinal digestion model; TNF-α | Cytology; Fruits; Microstructure; Nitric oxide; Scanning electron microscopy; Apple polyphenol; Apple polyphenol-chitooligosaccharide microcapsule; Cell viability; Chitooligosaccharides; Digestion models; Gastrointestinal digestion; IL-10; Microcapsules; RAW 264.7 cell; Simulated gastrointestinal digestion model; TNF α; Cells | English | 2020 | 2020-09-05 | 10.1186/s13765-020-00533-x | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Determination of veterinary pharmaceutical runoffs from a swine manure pile using LC-MS/MS | The mass usage of veterinary pharmaceuticals in farms has contributed to environmental pollution in vicinity waters, soils, and sediments from farms and composting facilities. In the present study, we investigated the usage of four antibiotics (viz., lincomycin, sulfamethazine, sulfamethoxazole, and trimethoprim) to understand their contamination routes from livestock manure piles. Residual levels of these antibiotics in a nearby reservoir were set as a positive control (Site 1), and a swine manure pile in a farm (Site 2) and a soil sample around the manure pile (Site 3) were selected for this study. Artificial rainwater was flowed into the manure sample (Site 2), the soil sample around the manure pile (Site 3), and a soil sample around the vicinity river (Site 4). A stream sample (Site 5) around the manure pile and river water near the manure pile (Site 6) were also collected. For qualitative and quantitative analyses, analytical validation was performed, and all the four antibiotics were detected at Site 1 in the concentration range of 0.03-1.6 mu g/L. Lincomycin was the antibiotic with the highest detection level. At Site 2, the detection level of all antibiotics remained at 0.3-17.3 mu g/L, and their residual amounts were continuously detected in subsequent samples with approximately 30-fold decrease. The migration of antibiotics was confirmed to be independent of pH value. Therefore, this study indicates that farm manure pile should be thoroughly managed for antibiotic contamination in vicinity areas with periodical monitoring, especially waterways. | Park, Min-Kyu; Oh, Joo-Yeon; Lee, Sung-Eun; Choi, Sung-Deuk | Ulsan Natl Inst Sci & Technol UNIST, Dept Urban & Environm Engn, Ulsan 44919, South Korea; Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea | Choi, Sung-Deuk/F-4827-2010 | 57037486700; 55389950700; 55890041600; 58530775200 | selpest@knu.ac.kr;sdchoi@unist.ac.kr; | APPLIED BIOLOGICAL CHEMISTRY | APPL BIOL CHEM | 2468-0834 | 2468-0842 | 63 | 1 | SCIE | FOOD SCIENCE & TECHNOLOGY | 2020 | 1.813 | 75.2 | 0.25 | 2025-06-25 | 8 | 8 | Veterinary antibiotics; Lincomycin; Sulfamethazine; Sulfamethoxazole; Monitoring | ANTIBIOTIC-RESISTANCE; FLUOROQUINOLONE; TOXICITY; RESIDUES; REMOVAL | Lincomycin; Monitoring; Sulfamethazine; Sulfamethoxazole; Veterinary antibiotics | Antibiotics; Farms; Fertilizers; Piles; Reservoirs (water); River pollution; Rivers; Sediments; Soil surveys; Soils; Detection levels; Environmental pollutions; LC-MS-MS; Lincomycin; Soil sample; Sulfamethazine; Sulfamethoxazole; Swine manure; Veterinary antibiotic; Veterinary pharmaceuticals; Manures | English | 2020 | 2020-11-03 | 10.1186/s13765-020-00559-1 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Identification of antifungal constituents of essential oils extracted fromBoesenbergia pulcherrimaagainst Fusarium wilt (Fusarium oxysporum) | With the aim of developing environment-friendly agricultural products with antifungal activity againstFusarium oxysporumf. sp. lycopersici, a causative agent of Fusarium wilt, active substances fromBoesenbergia pulcherrimaroots were isolated. The hexane fraction fromB. pulcherrimaroot extract was analyzed by GC/MS. The main peaks were estimated and identified to be methyl eugenol, methyl isoeugenol, elemicin, alpha-asarone, and 1,2-dimethoxy-4-(2-methoxyethenyl)benzene based on the Wiley library and by comparing retention times and mass spectra with their corresponding standards using GC/MS. For the identification of the compound in peak D that was estimated to be 1,2,4-trimethoxy-5-vinylbenzene, for which no reference standard was available, the hexane fraction was processed by column chromatography before NMR analysis. The result confirmed the compound to be 1,2,4-trimethoxy-5-vinylbenzene. Almost all compounds showed antifungal activity againstF. oxysporumbased on bioassays, and alpha-asarone had the highest activity. Therefore,B. pulcherrimaroot extract can be a potential source of environment-friendly agricultural products with antifungal activity againstF. oxysporum. | Park, Chan-joo; Kim, Hyun-sang; Lee, Dong Woon; Kim, Jinho; Choi, Yong-hwa | Kyungpook Natl Univ, Sch Ecol & Environm Syst, Sangju 37224, South Korea; Kyungpook Natl Univ, Dept Ecol Sci, Sangju 37224, South Korea | KIM, HYUNSANG/NGS-8674-2025 | 57218197259; 57195966638; 7406669991; 56376543200; 56173150200 | ychoi@knu.ac.kr; | APPLIED BIOLOGICAL CHEMISTRY | APPL BIOL CHEM | 2468-0834 | 2468-0842 | 63 | 1 | SCIE | FOOD SCIENCE & TECHNOLOGY | 2020 | 1.813 | 75.2 | 0.43 | 2025-06-25 | 12 | 13 | Antifungal active substance; 1; 2-Dimethoxy-4-(2-methoxyethenyl)benzene; Boesenbergia pulcherrima; Fusarium oxysporum | COMPONENT; RHIZOMES; ASARONE | 1,2-Dimethoxy-4-(2-methoxyethenyl)benzene; Antifungal active substance; Boesenbergia pulcherrima; Fusarium oxysporum | Agricultural products; Column chromatography; Essential oils; Fungi; Gas chromatography; Hexane; Mass spectrometry; 1,2-dimethoxy-4-(2-methoxyethenyl)benzene; Active substance; Antifungal active substance; Antifungal activities; Antifungals; Boesenbergium pulcherrima; Environment friendly; Fusarium oxysporums; Fusarium wilt; Root extracts; Benzene | English | 2020 | 2020-07-09 | 10.1186/s13765-020-00518-w | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | RNA sequencing reveals thatPrx IIgene knockout can down-regulate the allograft rejection of dermal mesenchymal stem cells | In this study, we used RNA sequencing (RNA-seq) to analyze and compare bulk cell samples from wild-type (WT) dermal mesenchymal stem cells (DMSCs) (n = 3) andPrx IIknockout DMSCs (n = 3). The purpose of the study was to elucidate the role ofPrx IIon allogeneic immune rejection of transplanted DMSCs. The results revealed differential expression of 472 genes (176 up-regulated and 296 down-regulated;p <= 0.05) between the PrxII(+/+)(WT) and PrxII(-/-)sample groups. When highly regulated genes were categorized according to the Gene Ontology (GO) molecular function classification and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, the PrxII(-/-)samples showed a robust downward trend in allograft rejection. The study identified 43 all immunologically rejected differentially expressed genes, of which 41 showed lower expression in the PrxII(-/-)vs. PrxII(+/+)(WT) samples. These findings suggest thatPrx IIgene knockout may down-regulate the allograft rejection that occurs during DMSCs transplantation and improve the survival rate of DMSCs in the host. This study provides a new perspective on the clinical treatment of stem cell transplantation. | Han, Ying-Hao; Mao, Ying-Ying; Yu, Nan-Nan; Jin, Mei-Hua; Jin, Ying-Hua; Wang, Ai-Guo; Zhang, Yong-Qing; Shen, Gui-Nan; Cui, Yu-Dong; Yu, Li-Yun; Lee, Dong-Seok; Jo, Yu-Jin; Sun, Hu-Nan; Kwon, Jeongwoo; Kwon, Taeho | Heilongjiang Bayi Agr Univ, Coll Life Sci & Biotechnol, Daqing 163319, Peoples R China; Heilongjiang Bayi Agr Univ, Lib & Informat Ctr, Daqing 163319, Peoples R China; Dalian Med Univ, Lab Anim Ctr, Dalian 116044, Peoples R China; Kyungpook Natl Univ, Coll Nat Sci, BK21 Plus KNU Creat BioRes Grp, KNU Ctr Nonlinear Dynam,CMRI,Sch Life Sci, Daegu 41566, South Korea; Korea Res Inst Biosci & Biotechnol KRIBB, Primate Resources Ctr, 351-33 Neongme Gil, Jeongeup Si 56216, Jeonbuk, South Korea; Chungbuk Natonal Univ, Dept Anim Sci, Cheongju 28864, Chungcheongbuk, South Korea | Han, Ying-Hao/IWU-6583-2023; Jin, Meihua/AAE-8526-2020; Kwon, Taeho/JLL-1095-2023; Mao, Yingying/Q-9996-2018; Cui, Yudong/MGT-9714-2025; Han, hao/IWU-6583-2023 | 7404096642; 57216651176; 57212654215; 57740660100; 8610761600; 57190730121; 57212661350; 36193289800; 24342913900; 8604011000; 57210068061; 56321088600; 8603267900; 56372575200; 57202850676 | hyhbynd@163.com;jwrichter1@naver.com;kwon@kribb.re.kr; | APPLIED BIOLOGICAL CHEMISTRY | APPL BIOL CHEM | 2468-0834 | 2468-0842 | 63 | 1 | SCIE | FOOD SCIENCE & TECHNOLOGY | 2020 | 1.813 | 75.2 | 0.25 | 2025-06-25 | 4 | 4 | Allograft rejection; Dermal mesenchymal stem cells; Peroxiredoxin II; RNA sequencing | CHEMOKINE; IDENTIFICATION; INFILTRATION; RECEPTOR; SURFACE; NKEF | Allograft rejection; Dermal mesenchymal stem cells; Peroxiredoxin II; RNA sequencing | Cell culture; Gene Ontology; Genes; Stem cells; Allograft rejection; Dermal mesenchymal stem cell; Gene knockout; Gene ontology; Immune rejection; Mesenchymal stem cell; Peroxiredoxin II; Regulated genes; RNA sequencing; Wild types; RNA | English | 2020 | 2020-06-22 | 10.1186/s13765-020-00515-z | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Sulforaphane induces colorectal cancer cell proliferation through Nrf2 activation in a p53-dependent manner | Sulforaphane is a well-known phytochemical that stimulates nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated antioxidant cellular response. In this study, we found that sulforaphane promoted cell proliferation in HCT116 human colon cancer cells expressing a normal p53 gene in a dose-dependent but biphasic manner. Since p53 has been reported to contribute to cell survival by regulating various metabolic pathways to adapt to mild stress, we further examined cellular responses in both p53-wild-type (WT) and p53-knockout (KO) HCT116 cells exposed to sulforaphane in vitro and in vivo. Results demonstrated that sulforaphane treatment activated Nrf2-mediated antioxidant enzymes in both p53-WT and p53-KO cells, decreased apoptotic protein expression in WT cells but increased in KO cells in a dose-dependent manner, and increased the expression of a mitochondrial biogenesis marker PGC1 alpha in WT cells but decreased in KO cells. Moreover, a low dose of sulforaphane promoted tumor growth, upregulated the Nrf2 signaling pathway, and decreased apoptotic cell death in p53-WT HCT116 xenografts compared to that in p53-KO HCT116 xenografts in BALB/c nude mice. These findings suggest that sulforaphane can influence colon cancer cell proliferation and mitochondrial function through a crosstalk between the Nrf2 signaling pathway and p53 axis. | Gwon, Yunjeong; Oh, Jisun; Kim, Jong-Sang | Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Kyungpook Natl Univ, Inst Agr Sci & Technol, Daegu 41566, South Korea | 57220632621; 56311554100; 37106950100 | vision@knu.ac.kr; | APPLIED BIOLOGICAL CHEMISTRY | APPL BIOL CHEM | 2468-0834 | 2468-0842 | 63 | 1 | SCIE | FOOD SCIENCE & TECHNOLOGY | 2020 | 1.813 | 75.2 | 0.86 | 2025-06-25 | 14 | 17 | Sulforaphane; Colon cancer; Biphasic growth; Nrf2; p53 | Biphasic growth; Colon cancer; Nrf2; p53; Sulforaphane | Antioxidants; Cancer cells; Cell death; Cell signaling; Diseases; Mammals; Mitochondria; Biphasic growth; Cellular response; Colon cancer; Colorectal cancer cell; Nrf2; P53; Signalling pathways; Sulforaphane; Wild types; Wild-type cells; Cell proliferation | English | 2020 | 2020-12 | 10.1186/s13765-020-00578-y | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
페이지 이동: