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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Review | Advantages of omics technology for evaluating cadmium toxicity in zebrafish | In the last decade, several advancements have been made in omics technologies and they have been applied extensively in diverse research areas. Especially in toxicological research, omics technology can efficiently and accurately generate relevant data on the molecular dynamics associated with adverse outcomes. Toxicomics is defined as the combination of toxicology and omics technologies and encompasses toxicogenomics, toxicoproteomics, and toxicometabolomics. This paper reviews the trend of applying omics technologies to evaluate cadmium (Cd) toxicity in zebrafish (D. rerio). Cd is a toxic heavy metal posing several environmental concerns; however, it is being used widely in everyday life. Zebrafish embryos and larvae are employed as standard models for many toxicity tests because they share 71.4% genetic homology with humans. This study summarizes the toxicity of Cd on the nerves, liver, heart, skeleton, etc. of zebrafish and introduces detailed omics techniques to understand the results of the toxicomic studies. Finally, the trend of toxicity evaluation in the zebrafish model of Cd based on omics technology is presented. | Min, Eun Ki; Lee, Ahn Na; Lee, Ji-Young; Shim, Ilseob; Kim, Pilje; Kim, Tae-Young; Kim, Ki-Tae; Lee, Sangkyu | Seoul Natl Univ Sci & Technol, Dept Environm Engn, Seoul 01811, South Korea; Kyungpook Natl Univ, Coll Pharm, Daegu 41566, South Korea; Natl Inst Environm Res, Environm Hlth Res Dept, Incheon 22689, South Korea; Gwangju Inst Sci & Technol, Sch Earth Sci & Environm Engn, Gwangju 61005, South Korea | ; KIM, KI-TAE/AAX-3175-2020; Shim, Ilseob/AAE-1919-2019 | 57221692953; 57711153600; 57269014600; 55355656300; 55272896600; 57049826900; 57202074566; 57209046767 | sangkyu@knu.ac.kr; | TOXICOLOGICAL RESEARCH | TOXICOL RES-GER | 1976-8257 | 2234-2753 | 37 | 4 | SCIE | TOXICOLOGY | 2021 | 3.019 | 64.4 | 0.21 | 2025-07-30 | 12 | 12 | Cadmium; Zebrafish; Toxicogenomics; Toxicoproteomics; Toxicometabolomics | Cadmium; Toxicogenomics; Toxicometabolomics; Toxicoproteomics; Zebrafish | English | 2021 | 2021-10 | 10.1007/s43188-020-00082-x | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Dynamic computed tomography evaluation of the nasopharynx in normal Beagle dogs | Pharyngeal collapsibility has been used as diagnostic criteria in dogs, whereas the normal range and quantitative method have not been studied. Dynamic and static computed tomography (CT) was performed in 23 normal Beagle dogs to quantify the nasopharyngeal collapsibility at different locations. Using dynamic CT, maximum and minimum nasopharyngeal cross-sectional areas (CSAs) were measured at the level of the cranial end of the soft palate, pterygoid hamulus, foramen lacerum, bony labyrinth, and caudal end of the soft palate. The ratio of all maximum and minimum CSA to nasopharyngeal CSA at the level of the caudal hard palate (rCSAmax and rCSAmin) and the nasopharyngeal collapsibility were calculated. The differences of rCSAmax, rCSAmin, and nasopharyngeal collapsibility were analyzed at various locations. The nasopharyngeal collapsibility at the level of foramen lacerum, bony labyrinth, and caudal end of soft palate were higher than the others. At the level of the caudal end of the soft palate, rCSAmin was lower than that of the foramen lacerum and bony labyrinth, whereas rCSAmax at foramen lacerum was higher than that of the caudal end of the soft palate. These results indicated that the nasopharynx at the level of foramen lacerum and caudal end of the soft palate were considered notable locations for evaluating collapsibility. Dynamic CT could show the nasopharyngeal dynamic profile and will be an adequate modality for evaluating nasopharynx. Our results will be helpful for further comparative studies in dogs with and without nasopharyngeal collapse. | Noh, Daji; Choi, Sooyoung; Choi, Hojung; Lee, Youngwon; Lee, Kija | Kyungpook Natl Univ, Coll Vet Med, Daegu 41566, South Korea; Kangwon Natl Univ, Coll Vet Med, Chunchon 24341, South Korea; Chungnam Natl Univ, Coll Vet Med, Daejeon 34134, South Korea | 57188552722; 55736574600; 35202930200; 8983566800; 35311016000 | leekj@knu.ac.kr; | JOURNAL OF VETERINARY MEDICAL SCIENCE | J VET MED SCI | 0916-7250 | 1347-7439 | 83 | 9 | SCIE | VETERINARY SCIENCES | 2021 | 1.105 | 64.5 | 0.93 | 2025-07-30 | 4 | 5 | collapsibility; dog; dynamic computed tomography; nasopharynx | UPPER-AIRWAY; SOFT PALATE; SLEEP; PHARYNX; DISEASES; COLLAPSE | Collapsibility; Dog; Dynamic computed tomography; Nasopharynx | Animals; Dogs; Nasopharynx; Palate, Hard; Palate, Soft; Skull; Tomography, X-Ray Computed; atipamezole; dexmedetomidine; Article; beagle; body weight; breathing pattern; breathing rate; canine tooth; comparative study; computer assisted tomography; cross-sectional study; endotracheal intubation; foramen magnum; hard palate; inner ear; lung auscultation; male; nasopharynx; nonhuman; polysomnography; positive end expiratory pressure ventilation; retching; sleep disordered breathing; sneezing; stridor; animal; diagnostic imaging; dog; skull; soft palate; veterinary medicine; x-ray computed tomography | English | 2021 | 2021-09 | 10.1292/jvms.21-0216 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Effect of a new cryotherapy device on an itchy sensation in patients with mild atopic dermatitis | Background The existence of an itchy sensation is a common complaint in patients with atopic dermatitis. More therapeutic modalities to address the itchy sensation in atopic dermatitis are still required. Objective We sought to assess the effect of a new cryotherapy device on the itchy sensation experienced by patients with atopic dermatitis. Methods A total of 28 patients with mild to moderate atopic dermatitis participated in this study. A split-body clinical trial was conducted for 2 months, where one side of each participant was treated with the novel cryotherapy device, and the other side of each participant was observed as a control. The cryotherapy device was set to -5 degrees C and applied for five seconds. We evaluated the visual analog scale (VAS) score for itch at 10, 30, and 60 minutes and at 1, 2 and 8 weeks after cryotherapy application. In addition, the level of patient satisfaction and adverse events were evaluated every visit. Results On the day immediately after treatment, the VAS score for itch in the treated-side group was lower following cryotherapy application than as compared within the control-side group. Further, the VAS score for itch in the treated-side group at baseline (before treatment) was higher than at 1, 2 and 8 weeks after treatment. The proportion of patients reporting good or excellent satisfaction was 14.3%. No serious adverse events were recorded. Conclusions The novel cryotherapy tested herein may be a valuable antipruritic therapeutic remedy in patients with atopic dermatitis. | Lee, Eun Hye; Lee, Hyun Ji; Park, Kyung Duck; Lee, Weon Ju | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Dermatol, Daegu, South Korea | 57189661699; 57207758693; 55767995700; 24474659000 | weonju@knu.ac.kr; | JOURNAL OF COSMETIC DERMATOLOGY | J COSMET DERMATOL-US | 1473-2130 | 1473-2165 | 20 | 9 | SCIE | DERMATOLOGY | 2021 | 2.189 | 64.5 | 0.6 | 2025-07-30 | 5 | 4 | atopic dermatitis; cryotherapy; itch | atopic dermatitis; cryotherapy; itch | Cryotherapy; Dermatitis, Atopic; Eczema; Humans; Pruritus; Sensation; adult; adverse event; Article; atopic dermatitis; clinical article; clinical assessment; clinical effectiveness; controlled clinical trial; controlled study; cooling; cryotherapy; dry skin; female; human; male; observational study; patient safety; patient satisfaction; pruritus; skin tingling; treatment duration; visual analog scale; atopic dermatitis; complication; eczema; pruritus; sensation | English | 2021 | 2021-09 | 10.1111/jocd.13975 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Correction | Gamma-ray bursts with extended emission: classifications, energy correlations and radiation properties (vol 20, pg 201, 2020) | Zhang, Xiao-Lu; Zhang, Chuan-Tao; Li, Xiu-Juan; Su, Fu-Fang; Dong, Xiao-Fei; Chang, Heon-Young; Zhang, Zhi-Bin | Qufu Normal Univ, Coll Phys & Engn, Qufu 273165, Shandong, Peoples R China; Kyungpook Natl Univ, Dept Astron & Atmospher Sci, 1370 Sankyuk Dong, Daegu 702701, South Korea; Qufu Normal Univ, Shandong Prov Key Lab Laser Polarizat & Informat, Qufu 273165, Shandong, Peoples R China | zhang, zhibin/IQS-5892-2023 | 58449541200; 57218183372; 57216877690; 8881632300; 57216888420; 7407524806; 57192634952 | astrophy0817@163.com; | RESEARCH IN ASTRONOMY AND ASTROPHYSICS | RES ASTRON ASTROPHYS | 1674-4527 | 2397-6209 | 21 | 3 | SCIE | ASTRONOMY & ASTROPHYSICS | 2021 | 1.889 | 64.5 | 0 | 2025-07-30 | 0 | 0 | English | 2021 | 2021-04 | 10.1088/1674-4527/21/3/078 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||||
| ○ | ○ | Article | Isolated isoquercitrin from Green ball apple peel inhibits photoaging in CCD-986Sk fibroblasts cells via modulation of the MMPs signaling | Background Ultraviolet B (UVB) irradiation is viewed as the main factor of skin aging, associated with acceleration of elastin, collagen degradation and expression of matrix metalloproteinases (MMPs). Apples are one of the most commonly eaten fruits in the world, and isoquercitrin is the main active ingredient in new bred varieties "Green ball" apple. Therefore, we are studying the functionality of the active ingredient of apple, a natural raw material that does not have toxicity or sensitivity problems. Objectives The aim of this study, we scrutinized the effects of isoquercitrin on skin photoaging in UVB-exposed human fibroblasts (CCD-986Sk). Methods To investigate the inhibition effect on photoaging factor regulation, isolated isoquercitrin were treated with UVB, which induces photoaging-related factors in CCD-986Sk fibroblast cells. Pro-inflammatory factors were measured by ELISA, Western blotting and real-time PCR. Results Isoquercitrin exhibited antioxidant activity and UVB-induced generation of photoaging-related factor inhibition without showing any toxicity. Anti-photoaging effect for protein levels using Isoquercitin was competent, of both the combate MMP-1 and MMP-9. Also, effect of COL1A2 product significantly increase, from up regulating the TIMP-1 mediated pathway in CCD-986Sk cells via the inhibition of MMPs. Isoquercitrin also downregulated the mRNA gene expression of MMPs while upregulating type I procollagen, HAS2 by modulating TIMP-1 and TGF-beta in UVB-irradiated CCD-986Sk cells. Conclusions Collectively, our results show that isoquercitrin might be useful as a functional food while being a good candidate in the development of cosmetic products and medicines for the remedy of UVB-induced skin photoaging. | Lee, Eun-Ho; Park, Hye-Jin; Kim, Han-Hyuk; Jung, Hee-Young; Kang, In-Kyu; Cho, Young-Je | Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Med Convergence Text Ctr, Res & Project Direct Team, Gyeongbuk Techno Pk, Gyongsan, South Korea; Kyungpook Natl Univ, Sch Appl Biosci, Daegu, South Korea; Kyungpook Natl Univ, Dept Hort Sci, Daegu, South Korea | 56347429100; 7601567655; 57204064907; 7403029383; 56577308800; 55265396300 | yjcho@knu.ac.kr; | JOURNAL OF COSMETIC DERMATOLOGY | J COSMET DERMATOL-US | 1473-2130 | 1473-2165 | 20 | 9 | SCIE | DERMATOLOGY | 2021 | 2.189 | 64.5 | 2.24 | 2025-07-30 | 16 | 16 | CCD-986Sk fibroblasts; green ball apple; isoquercitrin; photoaging; UVB stimulation | CCD-986Sk fibroblasts; green ball apple; isoquercitrin; photoaging; UVB stimulation | Animals; Fibroblasts; Humans; Malus; Matrix Metalloproteinases; Mice; Mice, Hairless; Quercetin; Skin; Skin Aging; Ultraviolet Rays; ascorbic acid; butylcresol; collagen type 1; gelatinase B; hyaluronan synthase 2; interstitial collagenase; isoquercetin; matrix metalloproteinase; procollagen; synthetase; tissue inhibitor of metalloproteinase 1; transforming growth factor beta; unclassified drug; isoquercetin; matrix metalloproteinase; quercetin; antioxidant activity; apple; Article; CCD-986Sk cell line; cell viability; controlled study; down regulation; drug effect; drug isolation; enzyme inhibition; enzyme linked immunosorbent assay; fruit peel; gene expression regulation; human; human cell; modulation; nonhuman; photoaging; protein expression level; real time polymerase chain reaction; ultraviolet B radiation; upregulation; Western blotting; adverse event; animal; cutaneous parameters; fibroblast; hairless mouse; Malus; mouse; skin; ultraviolet radiation | English | 2021 | 2021-09 | 10.1111/jocd.13903 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Optimal placement of the region of interest for bolus tracking on brain computed tomography angiography in Beagle dogs | This study aimed to determine the optimal placement of the region of interest (ROI) among four anatomical sites-pulmonary artery (PA), pulmonary vein (PV), aortic arch (AA), and carotid artery (CA)-in computed tomography (CT) brain angiography with automatic bolus tracking in healthy beagle dogs. Six beagles were included, and CT brain angiography was performed four times for each dog, to cover each ROI. The scan parameters, amount, and injection rate of the contrast medium were the same. The major intracranial arteries were selected for quantitative and qualitative evaluation: caudal cerebellar artery (CcA), basilar artery (BA), rostral cerebellar artery (RcA), caudal cerebral artery (CCA), middle cerebral artery (MCA), and rostral cerebral artery (RCA). Quantitative evaluation showed significantly higher CT attenuation values for the RcA, CCA, and MCA in the PA group and RcA and MCA in the PV group than in the CA group. Qualitative analysis revealed significantly higher scores for the BA, CCA, and MCA in the PA and PV groups than in the CA group. Venous contamination did not differ significantly among the ROIs, but the mean scores of the AA and CA groups were higher than those of the PA and PV groups. CT brain angiography using bolus tracking in the beagle dogs showed that the ROI should be placed at the PA or PV rather than at the CA for optimal images with strong contrast enhancement of the BA, RcA, CCA, and MCA and minimal venous contamination. | Park, Sieun; Jang, Min; Lee, Kija; Choi, Hojung; Lee, Youngwon; Park, Inchul; Choi, Sooyoung | Kangwon Natl Univ, Coll Vet Med, 1 Kangwondaehak Gil, Chunchon 24341, South Korea; Kyungpook Natl Univ, Coll Vet Med, 80 Daehak Ro, Daegu 41566, South Korea; Chungnam Natl Univ, Coll Vet Med, 99 Daehak Ro, Daejeon 34134, South Korea | 57226499346; 55341507600; 35311016000; 35202930200; 8983566800; 55721568100; 55736574600 | choisooyoung@kangwon.ac.kr; | JOURNAL OF VETERINARY MEDICAL SCIENCE | J VET MED SCI | 0916-7250 | 1347-7439 | 83 | 8 | SCIE | VETERINARY SCIENCES | 2021 | 1.105 | 64.5 | 0.74 | 2025-07-30 | 4 | 4 | bolus tracking; brain angiography; computed tomography; dog; region of interest placement | CONTRAST-MEDIUM VOLUME; ISCHEMIC-STROKE; REDUCTION | Bolus tracking; Brain angiography; Computed tomography; Dog; Region of interest placement | Angiography; Animals; Brain; Computed Tomography Angiography; Contrast Media; Dogs; Tomography, X-Ray Computed; contrast medium; angiography; animal; brain; computed tomographic angiography; diagnostic imaging; dog; veterinary medicine; x-ray computed tomography | English | 2021 | 2021-08 | 10.1292/jvms.20-0724 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Usefulness of home-use microneedle devices in the treatment of pattern hair loss | Background Microneedle devices have been used to reduce scarring and wrinkling as well as for the treatment of pattern hair loss. Aims Here, we investigated the efficacy and safety of a newly developed home-use microneedle device for the treatment of pattern hair loss. Methods Twenty-nine patients were assigned into three groups based on block randomization: home-use microneedle device only, a combination of home-use microneedle device and 5% minoxidil solution and 5% minoxidil topical solution only. Each treatment was performed twice a week. The study outcomes included hair counts, patient self-assessments, and adverse events at baseline and at 6 months. Statistical analyses were performed using analysis of variance (ANOVA), repeated measures ANOVA and Kruskal-Wallis test. Results The improvements in hair count were seen in the combination group at month 6, but the differences observed did not reach statistical significance in each group and among the three groups. The patient self-assessment showed the highest score in the combination group, but it did not reveal a statistically significant difference among the three groups. Mild and transient pruritus were reported by one patient who was using the microneedle device only. Conclusions Our study shows that the home-use microneedle device may be a safe and 5% minoxidil solution penetration-enhancing therapeutic modality for stimulating hair growth. | Sohng, Chihyeon; Lee, Eun Hye; Woo, Soo Kyeong; Kim, Jun Young; Park, Kyung Duck; Lee, Seok-Jong; Lee, Weon Ju | Kyungpook Natl Univ, Dept Dermatol, Sch Med, Kyungpook Natl Univ Hosp, Daegu, South Korea | ; Lee, Joong/A-5417-2013 | 57203820211; 57189661699; 57217390865; 35310922800; 55767995700; 56013454400; 24474659000 | weonju@knu.ac.kr; | JOURNAL OF COSMETIC DERMATOLOGY | J COSMET DERMATOL-US | 1473-2130 | 1473-2165 | 20 | 2 | SCIE | DERMATOLOGY | 2021 | 2.189 | 64.5 | 1.34 | 2025-07-30 | 9 | 11 | home-use microneedle device; minoxidil; pattern hair loss | TRANSDERMAL DRUG-DELIVERY; FINASTERIDE | home-use microneedle device; minoxidil; pattern hair loss | Administration, Topical; Alopecia; Analysis of Variance; Hair; Humans; Minoxidil; Needles; minoxidil; minoxidil; adult; Article; clinical article; clinical effectiveness; clinical outcome; controlled study; device safety; erythema; female; hair growth; hair loss; home; human; hypertrichosis; infection; intermethod comparison; male; priority journal; pruritus; self evaluation; skin irritation; skin swelling; alopecia; analysis of variance; hair; needle; topical drug administration | English | 2021 | 2021-02 | 10.1111/jocd.13540 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Bemisia tabaci in Java, Indonesia: genetic diversity and the relationship with secondary endosymbiotic bacteria | Bemisia tabaci is a complex of cryptic species of whitefly distributed worldwide; they are serious agricultural pests and vectors of plant viruses. Whiteflies are commonly infected by endosymbiotic bacteria, but the infection profiles among genetic groups of B. tabaci are highly complex. Here we analyzed the genetic variation of B. tabaci and endosymbiont infection patterns in Java, Indonesia. Specifically, adult B. tabaci were collected from four provinces and 43 partial cytochrome oxidase subunit I gene sequences were determined to identify the genotypes. Results showed that B. tabaci was grouped into three different cryptic species, Asia I, Asia II 5, and Asia II 7, at rates of 90.70%, 6.98%, and 2.32%, respectively. The dominant group, Asia I, was distributed throughout the island, whereas Asia II 5 and Asia II 7 were detected only in West Java. In these cryptic species, the infection rates of the secondary endosymbionts Arsenophonus, Cardinium, Hamiltonella, Rickettsia, and Wolbachia were 37.21%, 72.09%, 37.21%, 88.37%, and 90.70%, respectively. Arsenophonus and Cardinium were detected two subgroups (A1 and A2; C2 and C4), but Hamiltonella, Rickettsia, and Wolbachia were detected a one subgroup (H1, R1, and W1). The A1 and A2 subgroups were distributed in a mixed manner across the entire island; however, the C2 and C4 subgroups were distributed differentially in West Java and in Central and East Java, respectively. Multiple infections were common and their patterns were highly variable in each cryptic species. In particular, Hamiltonella was detected in Asia I and Asia II 5 but never coinfected with Arsenophonus in the same individual. Overall, this study shows that Asia I is the dominant genetic B. tabaci group on Java Island and that infection by endosymbionts occurs in a highly complex and sometimes geographically related manner. | Lestari, Susanti Mugi; Hidayat, Purnama; Hidayat, Sri Hendrastuti; Shim, Jae-Kyoung; Lee, Kyeong-Yeoll | Kyungpook Natl Univ, Coll Agr & Life Sci, Div Appl Biosci, Daegu 41566, South Korea; IPB Univ, Fac Agr, Dept Plant Protect, Bogor 16680, West Java, Indonesia; Kyungpook Natl Univ, Inst Agr Sci & Technol, Daegu, South Korea; Kyungpook Natl Univ, Inst Plant Med, Daegu, South Korea | Hidayat, Sri/AHC-2067-2022; Lestari, Susanti Mugi/JKH-8021-2023; Hidayat, Purnama/ACU-5509-2022 | 58428233700; 24284075000; 13403924200; 7201856347; 57217153096 | leeky@knu.ac.kr; | SYMBIOSIS | SYMBIOSIS | 0334-5114 | 1878-7665 | 83 | 3 | SCIE | MICROBIOLOGY | 2021 | 3.109 | 64.6 | 0.61 | 2025-07-30 | 5 | 6 | Cryptic species; Endosymbiotic bacteria; Genetic diversity; Symbiosis; Whitefly | Cryptic species; Endosymbiotic bacteria; Genetic diversity; Symbiosis; Whitefly | Asia; Central Department; East Java; Greater Sunda Islands; Indonesia; Indonesia; Java; Sunda Isles; West Java; Aleyrodidae; Arsenophonus; Bemisia tabaci; Candidatus Cardinium; Rickettsia; Subgroup A; Wolbachia; bacterium; crop pest; cytochrome; endosymbiont; gene expression; genetic variation; infectivity; whitefly | English | 2021 | 2021-04 | 10.1007/s13199-021-00752-w | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Chemogenetic stimulation of the Gi pathway in astrocytes suppresses neuroinflammation | Engineered G protein-coupled receptors (GPCRs) are commonly used in chemogenetics as designer receptors exclusively activated by designer drugs (DREADDs). Although several GPCRs have been studied in astrocytes using a chemogenetic approach, the functional role of the astrocytic G(i) pathway is not clear, as the literature is conflicting depending on the brain regions or behaviors investigated. In this study, we evaluated the role of the astrocytic G(i) pathway in neuroinflammation using a G(i)-coupled DREADD (hM4Di). G(i)-DREADD was expressed in hippocampal astrocytes of a lipopolysaccharide (LPS)-induced neuroinflammation mouse model using adeno-associated viruses. We found that astrocyte G(i)-DREADD stimulation using clozapine N-oxide (CNO) inhibits neuroinflammation, as characterized by decreased levels of proinflammatory cytokines, glial activation, and cognitive impairment in mice. Subsequent experiments using primary astrocyte cultures revealed that G(i)-DREADD stimulation significantly downregulated LPS-induced expression of Nos2 mRNA and nitric oxide production. Similarly, in vitro calcium imaging showed that activation of the astrocytic G(i) pathway attenuated intracellular calcium transients triggered by LPS treatment, suggesting a positive correlation between enhanced calcium transients and the inflammatory phenotype of astrocytes observed in the inflamed brain. Taken together, our results indicate that the astrocytic G(i) pathway plays an inhibitory role in neuroinflammation, providing an opportunity to identify potential cellular and molecular targets to control neuroinflammation. | Kim, Jae-Hong; Rahman, Md Habibur; Lee, Won Ha; Suk, Kyoungho | Kyungpook Natl Univ, Sch Med, Dept Pharmacol, 680 Gukchaebosang St, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, BK21 Plus KNU Biomed Convergence Program, Daegu, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu, South Korea; Kyungpook Natl Univ, Sch Life Sci, Brain Korea 21 Plus KNU Creat BioRes Grp, Daegu, South Korea | Rahman, Md Habibur/HMD-4572-2023 | 55926599800; 59607139800; 57205609794; 7005114595 | ksuk@knu.ac.kr; | PHARMACOLOGY RESEARCH & PERSPECTIVES | PHARMACOL RES PERSPE | 2052-1707 | 9 | 6 | SCIE | PHARMACOLOGY & PHARMACY | 2021 | 2.963 | 64.7 | 2.13 | 2025-07-30 | 23 | 20 | astrocyte; chemogenetics; G(i)-DREADD; hM4Di; neuroinflammation | NITRIC-OXIDE SYNTHASE; DESIGNER RECEPTORS; NA+/K+-ATPASE; EXPRESSION; ACTIVATION; NEUROPROTECTION; LIPOCALIN-2; INHIBITION; INDUCTION; MICROGLIA | astrocyte; chemogenetics; G<sub>i</sub>-DREADD; hM4Di; neuroinflammation | Animals; Astrocytes; Brain; Clozapine; Cognitive Dysfunction; Cytokines; Designer Drugs; Disease Models, Animal; GTP-Binding Protein alpha Subunits, Gi-Go; Hippocampus; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Molecular Targeted Therapy; Neuroinflammatory Diseases; Nitric Oxide; Nitric Oxide Synthase Type II; Receptors, G-Protein-Coupled; 4',6 diamidino 2 phenylindole; 4936; calcium chloride; carbon dioxide; clozapine n oxide; dimethyl sulfoxide; ether; fluorescein isothiocyanate; G protein coupled receptor; glial fibrillary acidic protein; glucose; glyceraldehyde 3 phosphate dehydrogenase; immunoglobulin G; inducible nitric oxide synthase; inhibitory guanine nucleotide binding protein; interleukin 1beta; isoflurane; lipopolysaccharide; messenger RNA; muscarinic receptor; n100 1028; neuron specific nuclear protein; neutrophil gelatinase associated lipocalin; nitrite; oxygen; paraformaldehyde; penicillin derivative; phosphate buffered saline; phosphoric acid; potassium chloride; red fluorescent protein; sodium chloride; sodium nitrite; streptomycin; sucrose; sulfanilamide; tumor necrosis factor; z0334; clozapine; clozapine N-oxide; cytokine; designer drug; G protein coupled receptor; inhibitory guanine nucleotide binding protein; lipopolysaccharide; nitric oxide; Nos2 protein, mouse; Adeno associated virus; agar gel electrophoresis; anesthesia; animal cell; animal experiment; animal model; animal tissue; Article; astrocyte; astrocyte culture; Barnes maze test; brain lateral ventricle; brain region; bregma; calcium cell level; centrifugation; cognitive defect; confocal microscopy; cryoprotection; electric shock; fetal bovine serum; flow rate; fluorescence; fluorescence intensity; fluorescence microscopy; gene expression; glia cell; GPCR signaling; hippocampal CA1 region; hippocampal tissue; immunofluorescence; immunohistochemistry; incubation time; lipopolysaccharide-induced neuroinflammation; male; Morris water maze test; mouse; mRNA expression level; nervous system inflammation; nonhuman; phenotype; promoter region; reverse transcription polymerase chain reaction; RNA extraction; staining; tissue section; training; ultraviolet radiation; upregulation; viral gene delivery system; virus infection; animal; astrocyte; brain; C57BL mouse; disease model; drug effect; genetics; hippocampus; metabolism; molecularly targeted therapy; pathophysiology | English | 2021 | 2021-12 | 10.1002/prp2.822 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Effect of combined ultrasound-enzyme treatment on recovery of phenolic compounds, antioxidant capacity, and quality of plum (Prunus salicina L.) juice | Plums are rich in antioxidant polyphenols mainly found in the skin, and a considerable amount is retained in the pomace after juice processing. This study investigated the impact of combined ultrasound-enzyme (UEZ) treatment (15-60 min) on antioxidant compounds recovery, quality, and extraction efficiency of plum-juice, in comparison with single treatments. The result revealed that UEZ could shorten treatment time (up to four times), with significantly (p < .05) higher yield, bioactive compounds and antioxidant capacity compared to untreated, ultrasound- and enzyme-treated juice samples, substantiating the effectiveness of combine-treatment over single-treatment. Moreover, clear juice obtained by UEZ (15 min), showed better and comparable physicochemical quality to juice from traditional enzymatic pretreatment (60 min). Furthermore, the antioxidant capacity of plum-juice, estimated by various radical scavenging assays correlated strongly with high contents of coumaric, ferulic, and chlorogenic acids, rutin, and catechin released in plum-juice. Overall, UEZ treatment expedited the production of clear plum-juice rich in antioxidant compounds. Practical Applications The skin of plum constitutes about 70% of the beneficial phytochemicals of the fruit, with a majority retained in the pomace when the conventional squeezing method is employed to produce juice. To benefit from these nutrients, enzymatic pretreatment is used to produce clear juice, and also recover these compounds in juice. However, it is often time-consuming. Hence, this study employed the combined use of ultrasound to intensify enzymatic extraction and facilitate the rapid recovery of beneficial phenolic compounds from the skin of plum into the extracted juice. The results obtained confirmed the synergistic impact of this technique in expediting clear juice production, with higher yields, antioxidant polyphenols, and better-quality properties. Thus, provided a practical solution for the efficient production of clear plum juice with potential health benefits. | Olawuyi, Ibukunoluwa F.; Akbarovich, Shamisev A.; Kim, Chang Kil; Lee, Won Young | Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Hort Sci, Daegu 41566, South Korea | ; Lee, Wonyoung/AAL-2780-2021; Shamsiev, Anvar/AAA-9338-2020; Olawuyi, Ibukunoluwa/H-1232-2018 | 57204471854; 57231876200; 7409880701; 57195940408 | ckkim@knu.ac.kr;wonyoung@knu.ac.kr; | JOURNAL OF FOOD PROCESSING AND PRESERVATION | J FOOD PROCESS PRES | 0145-8892 | 1745-4549 | 45 | 1 | SCIE | FOOD SCIENCE & TECHNOLOGY | 2021 | 2.609 | 64.9 | 1.33 | 2025-07-30 | 19 | 22 | VITAMIN-C CONTENTS; ASSISTED EXTRACTION; ASCORBIC-ACID; DOMESTICA L.; ANTHOCYANIN; CULTIVARS; STABILITY; COLOR; IDENTIFICATION; POLYPHENOLS | Enzymes; Extraction; Phenols; Recovery; Ultrasonic applications; Antioxidant capacity; Antioxidant compounds; Bioactive compounds; Enzymatic extraction; Enzymatic pretreatment; Extraction efficiencies; Physico-chemical quality; Practical solutions; Antioxidants | English | 2021 | 2021-01 | 10.1111/jfpp.15074 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Correction | Whispering gallery modes in triple microdisks of triangular configurations (vol 37, pg 2382, 2020) | Ryu, Jung-Wan; Rim, Sunghwan | Inst Basic Sci IBS, Ctr Theoret Phys Complex Syst, Daejeon 34126, South Korea; Kyungpook Natl Univ, Digital Technol Res Ctr, Daegu 41566, South Korea | 12768616200; 7005692465 | jungwanryu@gmail.com; | JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICS | J OPT SOC AM B | 0740-3224 | 1520-8540 | 38 | 1 | SCIE | OPTICS | 2021 | 2.058 | 64.9 | 0 | 2025-07-30 | 0 | 0 | English | 2021 | 2021-01-01 | 10.1364/josab.414875 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||||
| ○ | ○ | Article | β-amyrin-induced apoptosis in Candida albicans triggered by calcium | The emergence of drug-resistant pathogens has urged researchers to discover alternatives for traditional antibiotics. beta-amyrin, which is included in the category of triterpenoids extracted from plants, is known for its antimicrobial activity, although the underlying mechanism has not yet been revealed. This study was conducted to elucidate the antifungal mode of action of beta-amyrin against Candida albicans. Based on the relevance between triterpenoids and oxidative molecules, reactive oxygen species (ROS) concentrations were detected, which showed a noticeable increment. Disruption of Ca2+ homeostasis in the cytosol was additionally analyzed, which was supported by interactions between two. Subsequently, decrease in mitochondrial membrane potential, increment of mitochondrial Ca2+, and ROS concentration were monitored, which suggested mitochondrial dysfunction modulated by Ca2+. Further investigation confirmed oxidative damage through glutathione reduction and DNA fragmentation. Accumulation of lethal damages resulted in the activation of caspases and externalization of phosphatidylserine, indicating the induction of yeast apoptosis by beta-amyrin in C. albicans. (C) 2021 British Mycological Society. Published by Elsevier Ltd. All rights reserved. | Kwun, Min Seok; Lee, Ha Jung; Lee, Dong Gun | Kyungpook Natl Univ, BK21 FOUR KNU Creat BioRes Grp, Sch Life Sci, Daegu 41566, South Korea | Lee, Dong-Gun/IWD-9833-2023 | 57212491555; 57221856423; 55668060900 | dglee222@knu.ac.kr; | FUNGAL BIOLOGY | FUNGAL BIOL-UK | 1878-6146 | 1878-6162 | 125 | 8 | SCIE | MYCOLOGY | 2021 | 2.91 | 65.0 | 1.61 | 2025-07-30 | 22 | 22 | beta-amyrin; Calcium; Candida albicans; Yeast apoptosis; Reactive oxygen species | MITOCHONDRIAL DYSFUNCTION; ANTIMICROBIAL PEPTIDE; ANTIFUNGAL ACTIVITY; MECHANISM; MARKER; CELLS | Calcium; Candida albicans; Reactive oxygen species; Yeast apoptosis; β-amyrin | Antifungal Agents; Apoptosis; Calcium; Candida albicans; Membrane Potential, Mitochondrial; Mitochondria; Oleanolic Acid; Reactive Oxygen Species; Candida albicans; antifungal agent; beta-amyrin; calcium; oleanolic acid; reactive oxygen metabolite; apoptosis; calcium; mitochondrial DNA; pathogen; reactive oxygen species; yeast; apoptosis; Candida albicans; drug effect; metabolism; mitochondrial membrane potential; mitochondrion | English | 2021 | 2021-08 | 10.1016/j.funbio.2021.03.006 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Dispersion Behavior of Blast Furnace Sludge for Valuable Metal Recovery | Blast furnace sludge, which comes from the iron making process, contains many valuable materials including iron, carbon, and zinc, etc. Because a cohesive agent is added during filtration, fine sludge particles are agglomerated together. Therefore, This makes it necessary to disperse the sludge in solution before separating or recovering valuable materials. In this study, the effects of solid/liquid (g/L) ratio, ultrasonic dispersion conditions, the pH of solvent, and the concentration of dispersant on the dispersion of sludge were investigated by measuring the interfacial properties (zeta potential and hydrodynamic size) of sludge particles. High absolute value of zeta potential and small hydrodynamic size suggests that the sludge particles in the solution presents good dispersion. The absolute value of zeta potential increased gradually at high solid/liquid ratio and ultrasonic dispersion intensity. But when the sludge in solution was dispersed for more than 30 minutes, the absolute value of the zeta potential decreased due to increasing contact and interaction between the particles. Optimal dispersion operations were conducted and when the pH of the solution was adjusted to 11, the zeta potential value was measured to be -44.8 mV. This means that the sludge formed the most stable dispersed phase. The lowest zeta potential was measured to be -46.4 mV with the addition of sodium hexametaphosphate (NaPO3)(6) in the solution. It is thought that the sodium hexametaphosphate reduced ionic strength by removing alkali metal ions from the solution of sludge. | Jung, Jae-Heon; Lee, So-Yeong; Choi, Joo; Sohn, Ho-Sang | Kyungpook Natl Univ, Sch Mat Sci & Engn, Daegu 41566, South Korea; POSTEC, Grad Inst Ferrous Technol, Pohang 37673, South Korea | 57223244112; 57208210267; 57223248394; 7201426373 | sohn@knu.ac.kr; | KOREAN JOURNAL OF METALS AND MATERIALS | KOREAN J MET MATER | 1738-8228 | 59 | 5 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING | 2021 | 1.324 | 65.2 | 0.17 | 2025-07-30 | 2 | 2 | blast furnace; sludge; recycling; zeta potential; pH; dispersant | Blast furnace; Dispersant; PH; Recycling; Sludge; Zeta potential | Blast furnaces; Hydrodynamics; Ionic strength; Iron; Metal ions; Phosphorus compounds; Sodium compounds; Ultrasonic dispersion; Zeta potential; Blast furnace sludge; Dispersion behavior; Hydrodynamic size; Interfacial property; Iron making process; Optimal dispersion; Sodium hexametaphosphate; Valuable metal recovery; Metal recovery | Korean | 2021 | 2021-05 | 10.3365/kjmm.2021.59.5.295 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Exploring Binder and Solvent for Depositing Activated Carbon Electrode on Indium-Tin-Oxide Substrate to Prepare Supercapacitors | Supercapacitor electrode slurry is prepared for mass production by mixing activated carbon powder, conductive agent, and binder, which is then deposited on a substrate using the doctor-blade method. Polyvinylidene fluoride (PVDF) and 1-methyl-2-pyrrolidone (NMP) are used as binder and solvent, respectively, to form the electrode slurry on a metal substrate. In this study, ethyl cellulose (EC) is evaluated as a binder to prepare an electrode on an indium-tin-oxide (ITO) substrate obtaining transparent supercapacitors. Terpineol and isopropyl alcohol (IPA) are compared as suitable solvents for the EC binder. When terpineol is employed as a solvent, the conductive agent is uniformly deposited around the activated carbon powder. An electrode prepared using EC and terpineol exhibits slightly lower specific capacitance and rate performance than that using conventional PVDF and NMP. However, the electrode prepared using EC and terpineol securely adheres to the electrode components, resulting in a robust electrode. In contrast, an electrode prepared using EC and IPA exhibits high charge transfer resistance at the interface of the electrode/ electrolyte, leading to a low specific capacitance and rate performance. Thus, ecofriendly EC and terpineol can substitute the conventional PVDF and NMP for depositing activated carbon powder on an ITO substrate, while improving the specific capacitance of manufactured electrodes. | Choi, Young Mook; Chun, Sang-Eun | Kyungpook Natl Univ, Sch Mat Sci & Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Ind Technol Adv, Daegu 41566, South Korea | 57373623200; 36801080300 | sangeun@knu.ac.kr; | KOREAN JOURNAL OF METALS AND MATERIALS | KOREAN J MET MATER | 1738-8228 | 59 | 12 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING | 2021 | 1.324 | 65.2 | 0.33 | 2025-07-30 | 3 | 4 | ethyl cellulose; terpineol; indium-tin-oxide; specific capacitance; charge transfer resistance; adhesion | GLASS-TRANSITION TEMPERATURES; LITHIUM-ION; TRANSPARENT; PERFORMANCE; CELLULOSE; VOLATILE; BEHAVIOR | Adhesion; Charge transfer resistance; Ethyl cellulose; Indium-tin-oxide; Specific capacitance; Terpineol | Activated Carbon; Capacitance; Cellulose; Electrodes; Fluorine Compounds; Indium Compounds; Activated carbon; Capacitance; Cellulose; Electrodes; Fluorine compounds; Indium compounds; Solvents; Substrates; Supercapacitor; Activated carbon powder; Capacitance performance; Charge transfer resistance; Ethyl cellulose; Indium tin oxide substrates; Indium-tin-oxide; Isopropyl alcohols; Polyvinylidene fluorides; Rate performance; Specific capacitance; Tin oxides | English | 2021 | 2021-12 | 10.3365/kjmm.2021.59.12.911 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Method for Predicting Thermoelectric Module Efficiency Using MATLAB/Simulink | Development new high-performance thermoelectric materials for more efficient power generation systems and eco-friendly refrigerating systems has been challenging. Over the past few decades, thermoelectric studies have been focused on increasing the thermoelectric properties of materials. However, for conventional applications, developing of thermoelectric devices or modules with lower cost and simpler fabrication processes is also important. Simulation models that can predict the thermoelectric efficiency of modules using the thermoelectric properties of materials are needed for this purpose. In this study, we developed a simple model for calculating the efficiency of thermoelectric modules using MATLAB/Simulink. In this model, the temperature difference between the hot source and heat sink was fixed to ensure the precise comparisons of thermoelectric efficiency. The electric resistivity and Seebeck coefficient of thermoelectric materials was used in order to predict the efficiency of the thermoelectric modules. Then, the efficiency of the thermoelectric modules was verified using measured values which had been reported in prior experimental works. In this study, the simulated values were higher than the real thermoelectric effiency values. To address this, the simulations should consider the thermal resistance or electric contact resistance between the thermoelectric materials and electrodes. | Lee, Nayoung; Ye, Sungwook; Ur, Rahman Jamil; Tak, Jang-Yeul; Cho, Jung Young; See, Won Seon; Shin, Weon Ho; Commerell, Walter; Nam, Woo Hyun; Roh, Jong Wook | Kyungpook Natl Univ, Dept Adv Sci & Technol Convergence, Daegu 37224, South Korea; Kyungpook Natl Univ, Sch Nano & Mat Sci & Engn, Daegu 37224, South Korea; Korea Inst Ceram Engn & Technol, Energy & Environm Div, Seoul 52851, South Korea; Yonsei Univ, Dept Mat Sci & Engn, Seoul 03722, South Korea; Kwangwoon Univ, Elect Mat Engn, Seoul 01897, South Korea; Tech Hsch Ulm THU, Inst Energy & Drive Technol, D-89081 Ulm, Germany | ; Shin, Weon/AAH-4031-2020 | 57344191000; 57343753300; 57343753400; 55798158900; 55261296200; 34977532100; 57204152565; 56431049800; 36351054000; 25638796100 | whnam@kicet.re.kr;jw.roh@knu.ac.kr; | KOREAN JOURNAL OF METALS AND MATERIALS | KOREAN J MET MATER | 1738-8228 | 59 | 11 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING | 2021 | 1.324 | 65.2 | 0 | 2025-07-30 | 1 | 1 | thermoelectrics; efficiency; modules; simulation; MATLAB/Simulink; Seebeck effect | TRANSPORT-PROPERTIES; GENERATOR; OPTIMIZATION; PERFORMANCE; DESIGN; COOLER | Efficiency; MATLAB/Simulink; Modules; Seebeck effect; Simulation; Thermoelectrics | Forecasting; Materials properties; MATLAB; Refrigeration; Thermoelectric equipment; Thermoelectricity; MATLAB/ SIMULINK; Module; Module efficiency; Simulation; Thermo-Electric materials; Thermo-electric modules; Thermoelectric; Thermoelectric efficiency; Thermoelectric material; Thermoelectric properties; Efficiency | Korean | 2021 | 2021-11 | 10.3365/kjmm.2021.59.11.829 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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