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| ○ | ○ | Article | Lysobacter terrigena sp. nov., isolated from a Korean soil sample | A bacterial strain isolated from a soil collected in Jeju Island, designated as 17J7-1(T), was Gram-negative, rod-shaped, yellow colored, and motile by gliding. This strain was able to grow at temperature range from 10 to 42 degrees C, pH 7-9, and tolerated up to 1% NaCl. Analysis of 16S rRNA sequence identified strain 17J7-1(T) as a member of the genus Lysobacter with close sequence similarity with Lysobacter mobilis 9NM-14(T) (97.4%), Lysobacter xinjiangensis RCML-52(T) (97.0%), and Lysobacter humi FJY8(T) (96.9%). The genomic DNA G + C content of the isolate was 67.9 mol%. DNA-DNA relatedness between strain 17J7-1(T) and L. mobilis, L. humi, and L. xinjiangensis were 42.3%, 39.5%, and 35.8%, respectively, clearly showing that the isolate is distinct from its closest phylogenetic neighbors in the genus Lysobacter. Average nucleotide identity (ANI) and digital DNA-DNAhybridization (dDDH) values between strain 17J7-1(T) and L. enzymogenes ATCC 29487(T), the type species of this genus, and several other close Lysobacter species were less than 77% and 22%, respectively. Major fatty acids were C-16:0 iso (29.8%), summed feature 9 (C-17:1 iso omega 9c/C-16:0 10-methyl; 20.1%), and C-15:0 iso (17.7%). The predominant respiratory quinone was ubiquinone Q-8 and the major polar lipids were phosphatidylethanolamine, phosphatidylglycerol, and diphosphatidylglycerol. In the light of the polyphasic evidence accumulated in this study, strain 17J7-1(T) is considered to represent a novel species in the genus Lysobacter, for which name Lysobacter terrigena sp. nov. is proposed. The type strain is 17J7-1(T) (= KCTC 62217(T) = JCM 33057(T)). | Li, Weilan; Elderiny, Nabil Salah; Ten, Leonid N.; Lee, Seung-Yeol; Kim, Myung Kyum; Jung, Hee-Young | Kyungpook Natl Univ, Sch Appl Biosci, Daegu 41566, South Korea; Seoul Womens Univ, Dept Bio & Environm Technol, Seoul 01797, South Korea; Kyungpook Natl Univ, Inst Plant Med, Daegu 41566, South Korea | ; Lee, Hye Ah/ABC-8131-2021; Kim, Jung Oh/JDC-5061-2023; Elderiny, Nabil/AAL-2684-2020; Ten, Leonid/P-7941-2014 | 57196248967; 57195424553; 6603039265; 56106499600; 35080583500; 7403029383 | heeyoung@knu.ac.kr; | ARCHIVES OF MICROBIOLOGY | ARCH MICROBIOL | 0302-8933 | 1432-072X | 202 | 3 | SCIE | MICROBIOLOGY | 2020 | 2.552 | 73.2 | 0.27 | 2025-06-25 | 5 | 5 | Lysobacter; Lysobacteraceae; Soil bacteria | SPECIES DEFINITION; SEQUENCES; SLUDGE; GENE | Lysobacter; Lysobacteraceae; Soil bacteria | Bacterial Typing Techniques; Base Composition; DNA, Bacterial; Fatty Acids; Lysobacter; Phospholipids; Phylogeny; Republic of Korea; RNA, Ribosomal, 16S; Sequence Analysis, DNA; Soil Microbiology; bacterial DNA; bacterial RNA; cardiolipin; DNA; fatty acid derivative; genomic DNA; lipid; nucleotide; phosphatidylethanolamine; phosphatidylglycerol; RNA 16S; sodium chloride; ubiquinone derivative; ubiquinone q 8; unclassified drug; bacterial DNA; fatty acid; phospholipid; RNA 16S; Article; bacterial growth; bacterial strain; bacterium isolate; bacterium isolation; chemotaxonomy; DNA base composition; DNA DNA hybridization; genetic similarity; Lysobacter; Lysobacter enzymogenes; Lysobacter humi; Lysobacter mobilis; Lysobacter terrigena; Lysobacter xinjiangensis; nonhuman; nucleotide sequence; nucleotide sequence; pH; phylogenetic tree; priority journal; RNA sequence; salt tolerance; soil microflora; South Korea; strain identification; temperature; whole genome sequencing; bacterium identification; classification; DNA sequence; genetics; isolation and purification; Lysobacter; metabolism; microbiology; phylogeny | English | 2020 | 2020-04 | 10.1007/s00203-019-01776-z | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Methylobacterium segetis sp. nov., a novel member of the family Methylobacteriaceae isolated from soil on Jeju Island | A bacterial strain, 17J42-1(T), was isolated from a soil sample collected on Jeju Island, Republic of Korea. Colonies grown on R2A agar were pink in color, and cells were Gram-stain negative, short and rod-shaped. Analysis of 16S rRNA gene sequences identified this strain as a member of the genus Methylobacterium in the family Methylobacteriaceae, with high levels of 16S rRNA sequence similarity shared with Methylobacterium oxalidis 35a(T) (98.6%), Methylobacterium jeotgali S2R03-9(T) (97.5%), and Methylobacterium soli YIM 48816(T) (97.3%). Cells grew at 15-35 degrees C, pH 5-9, and in the presence of 0-1.0% NaCl. The genomic G + C content was 70.2 mol% based on the whole genome analysis. The predominant respiratory quinone was ubiquinone Q-10, the major fatty acid was C-18:1 omega 7c (85.3%), and the major polar lipids were phosphatidylcholine, phosphatidylethanolamine, phosphatidylglycerol, and diphosphatidylglycerol. The phenotypic and chemotaxonomic data support the affiliation of strain 17J42-1(T) with the genus Methylobacterium. However, the DNA-DNA relatedness between the isolate and its closest phylogenetic neighbors was lower than 38%. The OrthoANI and dDDH values between strain 17J42-1(T) and the closest type strain Methylobacterium oxalidis NBRC 107715(T) were calculated to be 85.9% and 30.6%, respectively. The results of 16S rRNA gene sequence similarity analysis, DNA-DNA hybridization analysis, and the observed differentiating phenotypic properties from other closely related taxa clearly indicate that strain 17J42-1(T) represents a novel species in the genus Methylobacterium, for which the name Methylobacterium segetis sp. nov. is proposed. The type strain is 17J42-1(T) (= KCTC 62267(T) = JCM 33059(T)). | Ten, Leonid N.; Li, Weilan; Elderiny, Nabil Salah; Kim, Myung Kyum; Lee, Seung-Yeol; Rooney, Alejandro P.; Jung, Hee-Young | Kyungpook Natl Univ, Sch Appl Biosci, Daegu 41566, South Korea; Seoul Womens Univ, Dept Bio & Environm Technol, Seoul 01797, South Korea; ARS, Crop Bioprotect Res Unit, USDA, Natl Ctr Agr Utilizat Res, Peoria, IL 61604 USA | Elderiny, Nabil/AAL-2684-2020; Ten, Leonid/P-7941-2014; Rooney, Alejandro/S-1201-2018; Kim, Jung Oh/JDC-5061-2023; Lee, Hye Ah/ABC-8131-2021 | 6603039265; 57196248967; 57195424553; 35080583500; 56106499600; 7003764429; 7403029383 | heeyoung@knu.ac.kr; | ARCHIVES OF MICROBIOLOGY | ARCH MICROBIOL | 0302-8933 | 1432-072X | 202 | 4 | SCIE | MICROBIOLOGY | 2020 | 2.552 | 73.2 | 0.4 | 2025-06-25 | 10 | 7 | Methylobacterium; Methylobacteriaceae; Soil bacteria | PROKARYOTIC GENOME ANNOTATION; EXTORQUENS AM1; GENE; HYBRIDIZATION; SEQUENCES; CLONING; SLUDGE | Methylobacteriaceae; Methylobacterium; Soil bacteria | Base Composition; Fatty Acids; Methylobacterium; Nucleic Acid Hybridization; Phylogeny; Republic of Korea; RNA, Ribosomal, 16S; Sequence Analysis, DNA; Soil Microbiology; Species Specificity; cardiolipin; genomic DNA; phosphatidylcholine; phosphatidylethanolamine; phosphatidylglycerol; RNA 16S; ubiquinone; fatty acid; Article; bacterial strain; bacterium culture; bacterium isolation; chemotaxonomy; DNA base composition; DNA DNA hybridization; gene sequence; genome analysis; lipid composition; Methylobacteriaceae; Methylobacterium; Methylobacterium segetis; nonhuman; nucleotide sequence; phenotype; phylogeny; priority journal; soil; soil microflora; South Korea; type strain; whole genome sequencing; chemistry; classification; DNA sequence; genetics; microbiology; nucleic acid hybridization; species difference | English | 2020 | 2020-05 | 10.1007/s00203-019-01784-z | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Review | Revisiting the plant growth-promoting rhizobacteria: lessons from the past and objectives for the future | Plant beneficial rhizobacteria (PBR) is a group of naturally occurring rhizospheric microbes that enhance nutrient availability and induce biotic and abiotic stress tolerance through a wide array of mechanisms to enhance agricultural sustainability. Application of PBR has the potential to reduce worldwide requirement of agricultural chemicals and improve agro-ecological sustainability. The PBR exert their beneficial effects in three major ways; (1) fix atmospheric nitrogen and synthesize specific compounds to promote plant growth, (2) solubilize essential mineral nutrients in soils for plant uptake, and (3) produce antimicrobial substances and induce systemic resistance in host plants to protect them from biotic and abiotic stresses. Application of PBR as suitable inoculants appears to be a viable alternative technology to synthetic fertilizers and pesticides. Furthermore, PBR enhance nutrient and water use efficiency, influence dynamics of mineral recycling, and tolerance of plants to other environmental stresses by improving health of soils. This report provides comprehensive reviews and discusses beneficial effects of PBR on plant and soil health. Considering their multitude of functions to improve plant and soil health, we propose to call the plant growth-promoting bacteria (PGPR) as PBR. | Aeron, Abhinav; Khare, Ekta; Jha, Chaitanya Kumar; Meena, Vijay Singh; Aziz, Shadia Mohammed Abdel; Islam, Mohammed Tofazzal; Kim, Kangmin; Meena, Sunita Kumari; Pattanayak, Arunava; Rajashekara, Hosahatti; Dubey, Ramesh Chandra; Maurya, Bihari Ram; Maheshwari, Dinesh Kumar; Saraf, Meenu; Choudhary, Mahipal; Verma, Rajhans; Meena, H. N.; Subbanna, A. R. N. S.; Parihar, Manoj; Shukla, Shruti; Muthusamy, Govarthanan; Bana, Ram Swaroop; Bajpai, Vivek K.; Han, Young-Kyu; Rahman, Mahfuzur; Kumar, Dileep; Singh, Norang Pal; Meena, Rajesh Kumar | Chonbuk Natl Univ, Div Biotechnol, Coll Environm & Bioresource Sci, Iksan 570752, South Korea; Chhatrapati Shahu Ji Maharaj Univ, Inst Biosci & Biotechnol, Dept Microbiol, Kanpur 208024, UP, India; Govt Sci Coll, Dept Microbiol, Surat 394430, Gujarat, India; VPKAS, ICAR, Almora 263601, UK, India; Natl Res Ctr, Microbial Chem Dept, Giza 12622, Egypt; Bangabandhu Sheikh Mujibur Rahman Agr Univ, Dept Biotechnol, Gazipur 1706, Bangladesh; IARI, ICAR, Div Soil Sci & Agr Chem, New Delhi 110012, India; Dr Rajendra Prasad Cent Agr Univ, Sugarcane Res Inst, Samastipur 848125, Bihar, India; Gurukula Kangri Univ, Dept Bot & Microbiol, Haridwar 249404, UK, India; BHU, Inst Agr Sci, Dept Soil Sci & Agr Chem, Varanasi 221005, UP, India; Agr Univ, SKN, SKN Coll Agr, Dept Soil Sci & Agr Chem, Jaipur 303329, Rajasthan, India; ATARI, ICAR, Jodhpur 342005, Rajasthan, India; Gujarat Univ, Univ Sch Sci, Dept Microbiol & Biotechnol, Ahmadabad 380009, Gujarat, India; IARI, ICAR, Div Agron, New Delhi 110012, India; Dongguk Univ Seoul, Dept Energy & Mat Engn, 30 Pildong Ro 1 Gil, Seoul 04620, South Korea; West Virginia Univ, Extens Serv, Morgantown, WV 26505 USA; AAU, Anand 388110, Gujarat, India; BHU, Inst Agr Sci, Dept Genet & Plant Breeding, Microbial Genet & PGPR Res Lab, Varanasi, UP, India; Univ Hyderabad, Sch Life Sci, Dept Plant Sci, Hyderabad 500046, India; NIFTEM, Dept Food Sci & Technol, Sonipat 131028, Haryana, India; Kyungpook Natl Univ, Dept Environm Engn, 80 Daehak Ro, Daegu 41566, South Korea | ; Bajpai, Vivek/C-7334-2017; Maheshwari, D/AAC-3451-2020; Rajashekara, H/KPY-7954-2024; shukla, shruti/M-7538-2016; Govarthanan, Muthusamy/C-1491-2014; Aeron, Abhinav/ACJ-0260-2022; Muthusamy, Govarthanan/C-1491-2014; Parihar, Manoj/ACI-5144-2022; Han, Young-Kyu/MIJ-9756-2025; Islam, Tofazzal/F-2563-2010; Islam, Tofazzal/C-9184-2013 | 36668120600; 59553017100; 36521045900; 55943461000; 57212079660; 58402647300; 15519369000; 57212087216; 6701485755; 56444535200; 7101947706; 36086479000; 26642958300; 57210272596; 57213068226; 57225817315; 53264452400; 56667515300; 57189644066; 26634567200; 54881927600; 55308555200; 15753535700; 7404096707; 55886744200; 58430271300; 57225725160; 57216071715 | vijayssac.bhu@gmail.com;vbajpai04@yahoo.com;ykenergy@dongguk.edu; | ARCHIVES OF MICROBIOLOGY | ARCH MICROBIOL | 0302-8933 | 1432-072X | 202 | 4 | SCIE | MICROBIOLOGY | 2020 | 2.552 | 73.2 | 1.44 | 2025-06-25 | 66 | 80 | Plant-beneficial rhizobacteria (PBR); Agro-ecosystems; Mineral solubilization; Soil-plant-microbes interaction; Microbial diversity | VOLATILE ORGANIC-COMPOUNDS; CICER-ARIETINUM L.; ANTIFUNGAL ACTIVITY; APHANOMYCES-COCHLIOIDES; SOLUBILIZING BACTERIA; SERRATIA-PLYMUTHICA; RHIZOCTONIA-SOLANI; FOLIAR APPLICATION; BIOLOGICAL-CONTROL; SALT TOLERANCE | Agro-ecosystems; Microbial diversity; Mineral solubilization; Plant-beneficial rhizobacteria (PBR); Soil–plant–microbes interaction | Agriculture; Bacteria; Bacterial Physiological Phenomena; Nitrogen; Plant Development; Plants; Soil; Soil Microbiology; Stress, Physiological; antibiotic agent; biosurfactant; hydrolase; iron; nitrogen; volatile organic compound; abiotic stress; agriculture; biotic stress; environmental sustainability; health; mobilization; nitrogen fixation; nonhuman; plant growth-promoting bacterium; plant root; priority journal; Review; rhizobacterium; rhizospheric microorganism; soil; solubilization; bacterial phenomena and functions; bacterium; chemistry; metabolism; microbiology; physiological stress; plant; plant development | English | 2020 | 2020-05 | 10.1007/s00203-019-01779-w | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Understanding the Role of Social Media in Political Participation: Integrating Political Knowledge and Bridging Social Capital From the Social Cognitive Approach | Recently, the relationship between use of social media and political participation has received increased scholarly scrutiny. Two main elements that reflect theoretical approaches to the relationship have been developed: political knowledge and bridging social capital. The current study integrates political knowledge and bridging social capital, using Bandura's social cognitive theory (SCT) on data collected from surveys conducted in the U.S. The results suggest that self-efficacy and outcome expectancy mediate the effects of political knowledge and bridging social capital on political participation. The proposed model represents the interactions among bridging social capital, political knowledge, self-efficacy, and outcome expectancy, providing an overall mechanism to assess the effects of social media on political participation using SCT. | Kim, Hyuksoo; Kim, Yeojin; Lee, Doohwang | Kyungpook Natl Univ, Daegu, South Korea; Cent Connecticut State Univ, New Britain, CT 06050 USA; Kyung Hee Univ, Seoul, South Korea | Lee, Doohwang/AAG-9222-2021 | 57110953000; 55767439700; 23467515800 | iumyum@knu.ac.kr;yeojinkim@ccsu.edu;doolee@khu.ac.kr; | INTERNATIONAL JOURNAL OF COMMUNICATION | INT J COMMUN-US | 1932-8036 | 14 | SSCI | COMMUNICATION | 2020 | 1.802 | 73.2 | 1.17 | 2025-06-25 | 14 | 18 | social media; political participation; social cognitive theory; social capital; political knowledge | COLLEGE-STUDENTS USE; SELF-EFFICACY; CIVIC ENGAGEMENT; NETWORK SITES; INTERNET USE; FACEBOOK USE; COMMUNICATION; INFORMATION; COMMUNITY; EXPOSURE | political knowledge; political participation; social capital; social cognitive theory; social media | English | 2020 | 2020 | 바로가기 | 바로가기 | 바로가기 | ||||||
| ○ | ○ | Article | Determination of Gleason score discrepancy for risk stratification in magnetic resonance-ultrasound fusion prostate biopsy | Background Magnetic resonance imaging (MRI)-ultrasound (US) fusion biopsy remains challenging and highlights the need towards standardization. Purpose To characterize the clinical and MRI features of clinically significant prostate cancer (csPCa) with discrepant Gleason score (GS) in MRI-US fusion biopsy. Material and Methods A total of 400 consecutive patients with suspected cancer lesions who underwent MRI-US fusion biopsy and subsequent prostatectomy were included. In the comparison of biopsy GS with pathology GS, matched lesions were defined as a GS, and discrepant lesions were defined as an upgrade of the GS. Descriptive statistics were used to define clinical characteristics, including age, prostate-specific antigen (PSA), PSA density, and maximal cancer core length (MCCL). Differences between lesions with matched and discrepant GS were determined considering the location and PI-RADS v2 score. A paired comparison of the volumes between the two groups was performed. Results There were 130 lesions with discrepant GS in 124 patients. There was no significant difference in the age, PSA, and PSA density between the two groups, except for the MCCL (P = 0.028). The lesions were distributed in the peripheral (n = 88) and transition (n = 42) zones; 33, 50, and 47 lesions were at the apex, mid-gland, and base levels, respectively. PI-RADS scores were as follows: 2 (n = 5), 3 (n = 8), 4 (n = 68), and 5 (n = 39). In comparison with matched lesions, discrepant lesions had significantly smaller multiparametric MRI-measured cancer volumes (P < 0.05). Conclusion Knowledge of discrepant GS in MRI-US fusion biopsy is important, and a careful approach is needed to reduce this discrepancy. | Kim, See Hyung | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Radiol, Daegu, South Korea | Kim, Sang-Hyun/J-5402-2012 | 57216511386 | kimseehyung72@outlook.kr; | ACTA RADIOLOGICA | ACTA RADIOL | 0284-1851 | 1600-0455 | 61 | 8 | SCIE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | 2020 | 1.99 | 73.3 | 0.17 | 2025-06-25 | 2 | 2 | Prostate cancer; magnetic resonance imaging-ultrasound fusion biopsy; Gleason score | MULTI-PARAMETRIC MRI; GUIDED BIOPSY; CANCER DETECTION; DIAGNOSIS | Gleason score; magnetic resonance imaging-ultrasound fusion biopsy; Prostate cancer | Aged; Aged, 80 and over; Humans; Image-Guided Biopsy; Magnetic Resonance Imaging; Male; Middle Aged; Multimodal Imaging; Neoplasm Grading; Prostatic Neoplasms; Retrospective Studies; Risk Assessment; Ultrasonography, Interventional; Antigens; Biopsy; Diseases; Magnetism; Resonance; Ultrasonics; Urology; gadolinium chelate; prostate specific antigen; Clinical characteristics; Descriptive statistics; Gleason scores; Paired comparison; Prostate biopsy; Prostate cancers; Prostate specific antigen; Risk stratification; age distribution; aged; Article; cancer diagnosis; cancer size; clinical feature; cohort analysis; controlled study; Gleason score; histopathology; human; human tissue; image guided biopsy; intermethod comparison; major clinical study; male; maximal cancer core length; multiparametric magnetic resonance imaging; nuclear magnetic resonance imaging; oncological parameters; priority journal; prostate biopsy; prostate cancer; prostate imaging reporting and data system; prostate volume; prostatectomy; radiological parameters; retrospective study; risk assessment; very elderly; cancer grading; comparative study; diagnostic imaging; image guided biopsy; interventional ultrasonography; middle aged; multimodal imaging; pathology; procedures; prostate tumor; risk assessment; Magnetic resonance imaging | English | 2020 | 2020-08 | 10.1177/0284185119891695 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Acute alcohol consumption-induced let-7a inhibition exacerbates hepatic apoptosis by regulating Rb1 in mice | Alcohol consumption is a critical risk factor for hepatic pathogenesis, including alcoholic liver diseases (ALD), but implications of alcohol-induced dysregulation of microRNA (miRNA) in ALD pathogenesis are not completely understood. In the present study, C57BL/6J male mice were treated with saline (CON; oral gavage; n = 8) or alcohol (EtOH; 3 g/kg body weight; oral gavage; n = 8) for 7 days. A total of 599 miRNAs and 158 key mRNAs related to fatty liver and hepatotoxicity pathways were assessed in mice liver tissues. The mRNA expression datasets were then utilized to predict interactions with miRNAs that were changed by alcohol consumption. Predicted miRNA-mRNA interactions were validated using in vitro miRNA transfection experiments. The results showed that let-7a was significantly decreased in the EtOH group and Rb1 mRNA was predicted as a target gene. This was further supported by an inverse correlation of RB1 and let-7a expression in mice liver tissue. Additionally, key protein expressions involved in RB1-apoptosis axis [i.e., p73, cleaved CASP-3 (cCASP-3), and cCASP-7] showed a trend of increase in the EtOH mice; this was also confirmed by capase-3 enzyme activity and terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling assay in livers of mice that had consumed alcohol. In line with our in vivo observations, alcohol treatment suppressed the let-7a expression and subsequently upregulated p73, cCASP-3, and cCASP-7 protein expressions in mice hepatocytes. Additional proteins in the apoptosis regulatory pathway (i.e., MDM2-p53 axis) were significantly changed in response to let-7a suppression in the cells. Taken together, the current study provides mechanistic evidence that alcohol consumption-induced let-7a suppression results in the upregulation of RB1, thereby promoting hepatic apoptosis through induction of pro-apoptotic proteins (e.g., p73), and by, at least in part, preventing MDM2-mediated p53 degradation. (C) 2019 Elsevier Inc. All rights reserved. | Pan, Jeong Hoon; Kim, Hyunjin; Tang, Jingsi; Beane, Kaleigh E.; Park, Jeen-Woo; Kong, Seongbae; Kong, Byungwhi C.; Kim, Young Jun; Shin, Eui-Cheol; Kim, Jun Ho; Zhao, Jiangchao; Lee, Jin Hyup; Kim, Jae Kyeom | Univ Arkansas, Sch Human Environm Sci, Fayetteville, AR 72701 USA; Kyungpook Natl Univ, Sch Life Sci, Coll Nat Sci, BK21 Plus KNU Creat Biores Grp, Daegu 41566, South Korea; Univ Arkansas, Dept Anim Sci, Fayetteville, AR 72701 USA; Univ Arkansas, Dept Poultry Sci, Fayetteville, AR 72701 USA; Korea Univ, Dept Food & Biotechnol, 2511 Sejong Ro, Sejong 30019, South Korea; Gyeongnam Natl Univ Sci & Technol, Dept Food Sci, Jinju 52725, South Korea; Andong Natl Univ, Dept Food Sci & Biotechnol, Andong 36729, South Korea; Univ Delaware, Dept Behav Hlth & Nutr, 25 N Coll Ave, Newark, DE 19716 USA | ; park, jun yeon/GPX-5293-2022; Kim, Jae Kyeom/AAE-8141-2022; Zhao, Jiangchao/J-4627-2014 | 57201234370; 57206212088; 57215680624; 57202287276; 35574514000; 57196096520; 7005061653; 59051181500; 57204010206; 56008351500; 53986735000; 36067819400; 57221817528 | jinhyuplee@korea.ac.kr;jkkim@udel.edu; | ALCOHOL | ALCOHOL | 0741-8329 | 1873-6823 | 85 | SCIE | PHARMACOLOGY & PHARMACY;SUBSTANCE ABUSE;TOXICOLOGY | 2020 | 2.405 | 73.4 | 0.17 | 2025-06-25 | 6 | 4 | alcoholic liver injury; apoptosis; let-7a; Rb1 | TUMOR-SUPPRESSOR; RETINOBLASTOMA; ACTIVATION; EXPRESSION; MICRORNAS; PATHWAY; DISEASE; GENES; P53 | alcoholic liver injury; apoptosis; let-7a; Rb1 | Alcohol Drinking; Animals; Apoptosis; Cell Proliferation; Ethanol; Fatty Liver; Liver; Liver Diseases, Alcoholic; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Retinoblastoma Binding Proteins; Up-Regulation; alanine aminotransferase; alcohol; aspartate aminotransferase; caspase 3; caspase 7; let 7a; microRNA; microRNA 21; protein MDM2; protein p53; Rb1 protein; retinoblastoma protein; tumor protein p73; unclassified drug; alcohol; microRNA; mirnlet7 microRNA, mouse; Rb1 protein, mouse; retinoblastoma binding protein; alcoholic fatty liver; AML12 cell line; animal cell; animal experiment; animal tissue; apoptosis; Article; controlled study; gene expression; liver; liver toxicity; male; mouse; nonhuman; protein degradation; protein expression; alcohol liver disease; animal; apoptosis; C57BL mouse; cell proliferation; drinking behavior; drug effect; fatty liver; genetics; liver; metabolism; upregulation | English | 2020 | 2020-06 | 10.1016/j.alcohol.2019.10.008 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Prognostic Value of Cystatin C-Derived Estimated Glomerular Filtration Rate in Patients with Acute Heart Failure | Background:Renal function is closely related to cardiac function and an important prognostic marker in heart failure.Objective:We aimed to test the prognostic value of cystatin C (cysC)-derived estimated glomerular filtration rates (eGFR) in comparison with eGFRs from creatinine solely based equations in patients with acute heart failure (AHF).Methods:This study included 262 patients (65.8 +/- 14.9 years old, 126 male) with AHF. Prognostic value of the eGFRs, from cysC-based equations chronic kidney disease epidemiology collaboration (CKD-EPI-cysC and CKD-EPI-creatinine [cr]-cysC equations) were compared with eGFRs calculated from serum creatinine levels only (Modification of Diet in Renal Disease [MDRD]-4 and CKD-EPI-cr equations). Prognosis was evaluated with the composite of all-cause mortality and hospitalization for heart failure within 1 year.Results:During the follow-up period (mean follow-up period, 264.0 +/- 136.1 days), 67 (25.6%) events occurred. Estimated GFR using CKD-EPI-cysC was the best for predicting 1-year outcome using receiver operating characteristic curve analysis (area under curve 0.585, 0.607, 0.669, and 0.652 for eGFRs from MDRD-4, CKD-EPI-cr, CKD-EPI-cysC, and CKD-EPI-cr-cysC respectively). The Kaplan-Meier survival curve analysis showed that only the eGFRs classification from the equations based on cysC significantly predicted 1-year outcome in patients with AHF.Conclusions:Estimated GFRs calculated with cysC predicted the prognosis more accurately in patients with AHF than the eGFRs from creatinine only equations. | Jang, Se Yong; Yang, Dong Heon; Kim, Hyeon Jeong; Park, Bo Eun; Park, Yoon Jung; Kim, Hong Nyun; Kim, Nam Kyun; Bae, Myung Hwan; Lee, Jang Hoon; Park, Hun Sik; Cho, Yongkeun; Chae, Shung Chull | Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ Hosp, Dept Internal Med, 130 Dongdeok Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Cardiol Ctr, Chilgok Hosp, Daegu, South Korea | Park, Hang-soo/AEH-1640-2022 | 57207977889; 35277423400; 57204359002; 57201131446; 57216539556; 56706769800; 55887032700; 36607356800; 54581258000; 57198844106; 9249593500; 7101962036 | ddhyang@knu.ac.kr; | CARDIORENAL MEDICINE | CARDIORENAL MED | 1664-3828 | 1664-5502 | 10 | 4 | SCIE | CARDIAC & CARDIOVASCULAR SYSTEMS;UROLOGY & NEPHROLOGY | 2020 | 2.041 | 73.6 | 0.66 | 2025-06-25 | 7 | 8 | Glomerular filtration rate; Heart failure; Prognosis; Cystatin C | RENAL-FUNCTION; SERUM CREATININE; DISEASE; MARKER; DYSFUNCTION; EQUATION; EVENTS; IMPACT; KIDNEY; DIET | Aged; Aged, 80 and over; Creatinine; Cystatin C; Glomerular Filtration Rate; Heart Failure; Humans; Male; Middle Aged; Prognosis; cystatin C; creatinine; cystatin C; acute heart failure; aged; all cause mortality; area under the curve; Article; chronic kidney disease epidemiology collaboration; controlled study; diagnostic test accuracy study; estimated glomerular filtration rate; female; follow up; hospitalization; human; major clinical study; male; Modification of Diet in Renal Disease; New York Heart Association class; priority journal; prognosis; receiver operating characteristic; retrospective study; risk factor; scoring system; sensitivity and specificity; survival rate; systolic blood pressure; turbidimetry; glomerulus filtration rate; heart failure; middle aged; prognosis; very elderly | English | 2020 | 2020-07 | 10.1159/000504084 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Gamma Knife Radiosurgery Using Co-Registration with PET-CT and MRI for Recurrent Nasopharyngeal Carcinoma with Previous Radiotherapy : A Single Center 14-Year Experience | Objective : We retrospectively evaluated the efficacy of Gamma Knife radiosurgery (GKS) for recurrent nasopharyngeal carcinoma (NPC) in patients who previously underwent radiotherapy, and analyzed the treatment outcomes over 14 years. Methods : Ten patients with recurrent NPC who had previously received radiotherapy underwent stereotactic radiosurgery using a Gamma Knife (R) (Elekta Inc, Atlanta, GA, USA) between 2005 and 2018. The median target volume was 8.2 cm(3) (range, 1.7-17.8), and the median radiation dose to the target was 18 Gy (range, 12-30). The median follow-up period was 18 months (range, 6-76 months). Overall and local failure-free survival rates were determined using the Kaplan-Meier method. Results : The NPCs recurred at the primary cancer site in seven patients (70%), as distant brain metastasis in two (20%), and as an extension into brain in one (10%). The recurrent tumors in seven of the 10 patients (70%) were found on the routine follow-up imaging studies. Two patients presented with headache and one with facial pain. Local failure after GKS occurred in five patients (50%) : two of whom died eight and 6 months after GKS, respectively. No adverse radiation effects were noted after GKS. The 1- and 3-year overall survival rates after GKS were 90% and 77%, respectively. The local failure-free survival rates at 6 months, 1 year, and 3 years after GKS were 80%, 48%, and 32%, respectively. The median interval from GKS to local failure was 8 months (range, 6-12). Univariate analysis revealed that using co-registration with positron emission tomography-computed tomography (PET-CT) and magnetic resonance imaging (MRI) was associated with a lower local failure rate of recurrent NPC (p=0.027). Conclusion : GKS is an acceptable salvage treatment option for patients with recurrent NPC who previously received radiation therapy. PET-CT and MRI co-registration for dose planning can help achieve local control of recurrent NPC. | Lee, Chaejin; Park, Seong-Hyun; Yoon, Sang-Youl; Park, Ki-Su; Hwang, Jeong-Hyun; Hwang, Sung-Kyoo | Kyungpook Natl Univ, Sch Med, Dept Neurosurg, Daegu, South Korea; Kyungpook Natl Univ Hosp, Dept Neurosurg, Daegu, South Korea | 57211989339; 21734563200; 57195615457; 55932363100; 7403896906; 8568620500 | nsdoctor@naver.com; | JOURNAL OF KOREAN NEUROSURGICAL SOCIETY | J KOREAN NEUROSURG S | 2005-3711 | 1598-7876 | 63 | 3 | SCIE | CLINICAL NEUROLOGY;SURGERY | 2020 | 1.729 | 73.7 | 0.51 | 2025-06-25 | 5 | 5 | Radiosurgery; Nasopharyngeal carcinoma; Positron emission tomography computed tomography | STEREOTACTIC RADIOSURGERY; LOCAL FAILURES | Nasopharyngeal carcinoma; Positron emission tomography computed tomography; Radiosurgery | English | 2020 | 2020-05 | 10.3340/jkns.2019.0011 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | In-Vitro Study of Urokinase Thrombolysis Following Stereotactic Aspiration of Intracerebral Hematoma | Objective : A consensus regarding the ideal regimen for urokinase (UK) thrombolysis subsequent to stereotactic spontaneous intracerebral hemorrhage aspiration has yet to be established. The purpose of this study is to evaluate the efficacy of UK thrombolysis relative to when the regimen is changed. Methods : Venous blood from 30 heathy volunteers was obtained for this in-vitro study. Various concentrations of UK solution were added to microcentrifuge tubes containing the clotted blood. The efficacy of UK thrombolysis was identified by checking the weight of lysed hematoma following various time intervals with different concentrations of UK solution. Group one, the "3x4" group involved four administrations every 3 hours over 12 hours, and group two, the "6x2" group involved two administrations every 6 hours over 12 hours. Results : More hematoma was lysed in the 3x4 group than the 6x2 group across all concentration levels (however, the differences were only significant between groups at the 500 and 1000 IU concentration levels, p<0.05). There were no significant differences of lysed hematoma among the various UK solution concentrations within groups. Conclusion : This study suggests that frequent administrations of UK thrombolysis may result in a greater degree of lysed hematoma in comparison to a higher concentration of UK. | Son, Wonsoo; Park, Jaechan; Kang, Dong-Hun; Han, Young-Min; Choi, Yeon-Ju; Ohk, Boram | Kyungpook Natl Univ, Sch Med, Dept Neurosurg, Daegu, South Korea; Kyungpook Natl Univ Hosp, Dept Clin Trial Ctr, Daegu, South Korea | 36676729400; 44661451000; 8977805800; 57304170500; 57191877683; 57189367079 | jparkmd@hotmail.com; | JOURNAL OF KOREAN NEUROSURGICAL SOCIETY | J KOREAN NEUROSURG S | 2005-3711 | 1598-7876 | 63 | 3 | SCIE | CLINICAL NEUROLOGY;SURGERY | 2020 | 1.729 | 73.7 | 0 | 2025-06-25 | 0 | 0 | Urokinase-type plasminogen activator; Thrombolytic therapy; Cerebral hemorrhage; In-vitro techniques | TISSUE-PLASMINOGEN-ACTIVATOR; FIBRINOLYTIC THERAPY; DELAYED EDEMA; HEMORRHAGE; LYSIS; REDUCTION; STROKE; MODEL; CLOT | Cerebral hemorrhage; In-vitro techniques; Thrombolytic therapy; Urokinase-type plasminogen activator | urokinase; Article; blood clot lysis; blood clotting; blood sampling; brain hematoma; controlled study; fibrinolytic therapy; human; in vitro study; stereotactic aspiration; thrombus weight | English | 2020 | 2020-05 | 10.3340/jkns.2018.0224 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Prediction of Risk Factors after Spine Surgery in Patients Aged >75 Years Using the Modified Frailty Index | Objective : Spine surgery is associated with higher morbidity and mortality rates in elderly patients. The modified Frailty Index (mFI) is an evaluation tool to determine the frailty of an individual and how preoperative status may impact postoperative survival and outcomes. This study aimed to determine the usefulness of mFI in predicting postoperative complications in patients aged >= 75 years undergoing surgery with instrumentation. Methods : We retrospectively reviewed the perioperative course of 137 patients who underwent thoracolumbar-instrumentation spine surgery between 2011 and 2016. The preoperative risk factors were the 11 variables of the mFI, as well as body mass index (kg/cm(2)), preoperative hemoglobin, platelet, albumin, creatinine, anesthesia time, operation time, estimated blood loss, and transfusion amount. The 60-day occurrences of complication rates were used for outcome assessment. Results : Major complications after spinal instrumentation surgery occurred in 34 of 138 patients (24.6%). The mean mFI score was 0.18 +/- 0.12. When we divided patients into a pre-frail group (mFI, 0.09-0.18; n=94) and a frail group (mFI >= 0.27; n=44), only the rate of sepsis was statistically higher in the frail group than in the pre-frail group. There were significantly more major complications in patients with low albumin levels or in patients with infection or who had experienced trauma. The mFI was a more useful predictor of postoperative complications than the American Society of Anesthesiologists physical status score. Conclusion : The mFI can successfully predict postoperative morbidity and mortality in patients aged >= 75 years undergoing spine surgery. The mFI improves perioperative risk stratification that provides important information to assist in the preoperative counselling of patients and their families. | Kim, Ji-Yoon; Park, In Sung; Kang, Dong-Ho; Lee, Young-Seok; Kim, Kyoung-Tae; Hong, Sung Jin | Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Anesthesiol Pain & Crit Care Med, Daegu, South Korea; Gyeongsang Natl Univ, Gyeongsang Natl Univ Hosp, Dept Neurosurg, Sch Med, Jinju, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Neurosurg, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Neurosurg, Daegu, South Korea; Catholic Univ Korea, Coll Med, Dept Anesthesiol Pain & Crit Care Med, Yeouido St Marys Hosp, 10 63 Ro, Seoul 07345, South Korea | 57205408095; 36794338800; 57744022100; 57203798682; 57201369790; 55860235300 | hongs@catholic.ac.kr; | JOURNAL OF KOREAN NEUROSURGICAL SOCIETY | J KOREAN NEUROSURG S | 2005-3711 | 1598-7876 | 63 | 6 | SCIE | CLINICAL NEUROLOGY;SURGERY | 2020 | 1.729 | 73.7 | 1.02 | 2025-06-25 | 16 | 16 | Frail elderly; Risk assessment; Postoperative complications; Morbidity; Spine | MEDICAL COMPLICATIONS; ELDERLY-PATIENTS; SERUM-ALBUMIN; MORTALITY; MORBIDITY; OUTCOMES; HEALTH | Frail elderly; Morbidity; Postoperative complications; Risk assessment; Spine | albumin; creatinine; hemoglobin; acute kidney failure; aged; anesthesia; angina pectoris; Article; bleeding; blood transfusion; body mass; cerebrovascular accident; chronic obstructive lung disease; clinical outcome; comparative study; deep vein thrombosis; degenerative disease; diabetes mellitus; female; frail elderly; heart arrest; heart failure; heart infarction; heart surgery; human; hypertension; infection; injury; intubation; lung embolism; male; metastasis; morbidity; mortality; operation duration; percutaneous coronary intervention; peripheral vascular disease; pneumonia; postoperative complication; retrospective study; risk assessment; risk factor; sepsis; spine surgery; surgical infection; thoracolumbar spine; thrombocyte; urinary tract infection | English | 2020 | 2020-11 | 10.3340/jkns.2020.0019 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Role of Balloon Guide Catheter in Modern Endovascular Thrombectomy | Proximal flow control achieved with a balloon guide catheter (BGC) during endovascular treatment of acute ischemic stroke is reviewed in this article. In clinical practice, BGCs offer a multi-faceted approach for clot retrieval by creating proximal flow arrest, reducing embolic burden, and shortening procedure time. Evaluation of frontline thrombectomy procedures with BGCs revealed advantages of combined use over the conventional guide catheter (CGC), notably in the significant reduction of distal emboli to both the affected and previously unaffected territories. Recently, new measures of early and complete reperfusion at first thrombectomy pass have been identified as independent predictors of improved outcomes, which were consistently demonstrated with use of BGC as a safe and effective option to minimize number of passes during intervention. Prior randomized controlled trials reported the positive correlation between BGC-treated patients and a lower risk of mortality as well as shortened procedure time. While BGC use is more common in stent retriever-mediated mechanical thrombectomy, preliminary data has shown the potential benefit of device application during contact aspiration thrombectomy to achieve successful recanalization. However, the question of which major endovascular strategy reigns superior as a frontline remains to be answered. Along with clinical case assessments, BGC performance during in-vitro simulation was analyzed to further understand mechanisms for optimization of thrombectomy technique. | Chueh, Ju-Yu; Kang, Dong-Hun; Kim, Byung Moon; Gounis, Matthew J. | Univ Massachusetts, Med Sch, Dept Radiol, New England Ctr Stroke Res, 55 Lake Ave North,SA-107R, Worcester, MA 01655 USA; Kyungpook Natl Univ, Sch Med, Dept Neurosurg & Radiol, Daegu, South Korea; Yonsei Univ, Severance Hosp, Severance Stroke Ctr, Coll Med,Dept Radiol, Seoul, South Korea | 57208484667; 8977805800; 49861594200; 6603206927 | matthew.gounis@umassmed.edu; | JOURNAL OF KOREAN NEUROSURGICAL SOCIETY | J KOREAN NEUROSURG S | 2005-3711 | 1598-7876 | 63 | 1 | SCIE | CLINICAL NEUROLOGY;SURGERY | 2020 | 1.729 | 73.7 | 1.2 | 2025-06-25 | 38 | 38 | Acute stroke; Balloon occlusion; Endovascular thrombectomy; Thrombectomy | ACUTE ISCHEMIC-STROKE; STENT-RETRIEVER THROMBECTOMY; LARGE VESSEL OCCLUSION; SOLITAIRE DEVICE ANALYSIS; 1ST PASS TECHNIQUE; MECHANICAL THROMBECTOMY; ASPIRATION THROMBECTOMY; CLINICAL-OUTCOMES; IMPROVES REVASCULARIZATION; DISTAL EMBOLIZATION | Acute stroke; Balloon occlusion; Endovascular thrombectomy; Thrombectomy | anterior cerebral artery; anticoagulant therapy; atherosclerosis; atrial fibrillation; balloon embolization; balloon occlusion; blood clot; blood clot lysis; brain damage; brain ischemia; brain tolerance; carotid artery flow; cerebrovascular accident; clinical assessment; clinical outcome; clinical practice; computer simulation; endovascular surgery; flow arrest; hemodynamics; human; internal carotid artery; mechanical thrombectomy; mortality rate; particle size; percutaneous thrombectomy; recanalization; Review; surgical technique; thrombectomy; thrombus aspiration; time to treatment | English | 2020 | 2020-01 | 10.3340/jkns.2019.0114 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Supraorbital Keyhole Approach for Intracranial Aneurysms : Transitioning from Concerns to Confidence | For surgical minimalism to reduce iatrogenic traumatization, a supraorbital keyhole approach has already been successfully applied to treat many unruptured anterior circulation aneurysms. However, using this minimal approach also raises several technical concerns due to the small cranial opening and cosmetic impact of a facial incision. Yet, such technical limitations can be overcome by using favorable surgical indications, slender surgical instruments, and optimized surgical techniques, while excellent cosmetic outcomes can be achieved using a short skin incision located <1 cm from the supraorbital margin, reconstruction of any bone defects around the bone flap, and meticulous wound closure. Thus, given such reassuring surgical results, in terms of the clipping status, neurological effects, and cosmetic outcomes, any concerns can be transitioned into confidence. | Park, Jaechan | Kyungpook Natl Univ, Sch Med, Dept Neurosurg, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Biomed Res Inst, Daegu, South Korea | 44661451000 | jparkmd@hotmail.com; | JOURNAL OF KOREAN NEUROSURGICAL SOCIETY | J KOREAN NEUROSURG S | 2005-3711 | 1598-7876 | 63 | 1 | SCIE | CLINICAL NEUROLOGY;SURGERY | 2020 | 1.729 | 73.7 | 0.93 | 2025-06-25 | 11 | 18 | Craniotomy; Intracranial aneurysm; Minimally invasive surgical procedures | SUPERCILIARY KEYHOLE; MICROSURGICAL EXPERIENCE; OLFACTORY NERVE; FRONTAL BRANCH; FACIAL-NERVE; SURGERY; CRANIOTOMY; OPERATIONS | Craniotomy; Intracranial aneurysm; Minimally invasive surgical procedures | bipolar coagulator; hydroxyapatite; unclassified drug; anterior cerebral artery; anterior communicating artery; bone defect; bone graft; bone remodeling; cerebrospinal fluid; craniotomy; emotional stress; epidural hematoma; frontal sinus; hair loss; human; internal carotid artery; intracranial aneurysm; middle cerebral artery; neuralgia; olfactory nerve; olfactory tract; osteotomy; outcome assessment; paralysis; pars triangularis; patient satisfaction; posterior communicating artery; Review; skin incision; subarachnoid hemorrhage; surgical technique; Sylvian fissure; thermal injury; wound closure | English | 2020 | 2020-01 | 10.3340/jkns.2019.0042 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Clinical and radiological outcomes between biportal endoscopic decompression and microscopic decompression in lumbar spinal stenosis | Background context: Numerous minimal invasive techniques treating lumbar spinal stenosis have been introduced. Clinical results using biportal endoscopic spinal surgery has recently been introduced as a treatment option for lumbar spinal stenosis. The purpose of this study was to compare the clinical and radiologic outcome between microscopic unilateral laminotomy bilateral decompression and biportal endoscopic unilateral laminotomy bilateral decompression in patients with degenerative lumbar spinal stenosis. Method: A total of 89 patients were evaluated for this study. Only single-level patients were enrolled for accurate comparison. Patients that underwent biportal endoscopic surgery were assigned to Group A, and patients that underwent microscopic surgery were designated Group B. Clinical outcomes were evaluated using modified Macnab criteria, Oswestry Disability Index, and Visual Analog Scale. Postoperative complications were checked until final follow up. Plain radiographs before and after surgery were compared to analyze the change of alignment. Result: There was a significant difference between Group A and B in VAS of back on postoperative 2 months. Other clinical measurements except for postoperative 2 months VAS of back showed no significant difference. There were no significant differences between Group A and Group B regarding preoperative and postoperative radiological findings. Conclusion: Two different decompression techniques preserve the spinal structure and exhibit a favorable clinical outcome and have the advantage of not causing postoperative instability in the short term follow up. Biportal endoscopic surgery may leads to less postoperative back pain than microscopic surgery, which may allow early ambulation and shorter hospitalization period. (C) 2019 The Japanese Orthopaedic Association. Published by Elsevier B.V. All rights reserved. | Min, Woo-Kie; Kim, Ju-Eun; Choi, Dae-Jung; Park, Eugene J.; Heo, Jeong | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Dept Orthoped Surg, Sch Med, Daegu, South Korea; Himnaera Hosp, Pusan, South Korea; Chungnam Natl Univ, Sch Med, Dept Orthopaed Surg, Daejeon, South Korea | ; Park, Eugene/P-1473-2018; Jeong, Sook-Hyang/J-5642-2012 | 8548041000; 56487007900; 57061435000; 55371642100; 56970488400 | dspfuture@hanmail.net; | JOURNAL OF ORTHOPAEDIC SCIENCE | J ORTHOP SCI | 0949-2658 | 1436-2023 | 25 | 3 | SCIE | ORTHOPEDICS | 2020 | 1.601 | 73.8 | 7.35 | 2025-06-25 | 66 | 84 | BILATERAL DECOMPRESSION; UNILATERAL LAMINOTOMY; LAMINECTOMY; SURGERY | Aged; Decompression, Surgical; Disability Evaluation; Endoscopy; Female; Humans; Lumbar Vertebrae; Male; Middle Aged; Pain Measurement; Spinal Stenosis; aged; Article; backache; biportal endoscopic unilateral laminotomy bilateral decompression; clinical outcome; disability; endoscopic surgery; epidural hematoma; female; follow up; human; intermethod comparison; lumbar spinal stenosis; major clinical study; male; microscopic unilateral laminotomy bilateral decompression; microsurgery; mobilization; nuclear magnetic resonance imaging; operation duration; Oswestry Disability Index; outcome assessment; patient satisfaction; peroperative complication; postoperative complication; postoperative pain; spinal cord decompression; spine radiography; visual analog scale; comparative study; decompression surgery; diagnostic imaging; endoscopy; lumbar vertebra; middle aged; pain measurement; procedures; vertebral canal stenosis | English | 2020 | 2020-05 | 10.1016/j.jos.2019.05.022 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Cyclic parallel hypersurfaces in complex Grassmannians of rank 2 | The object of the paper is to study cyclic parallel hypersurfaces in complex (hyperbolic) two-plane Grassmannians which have a remarkable geometric structure as Hermitian symmetric spaces of rank 2. First, we prove that if the Reeb vector field belongs to the orthogonal complement of the maximal quaternionic subbundle, then the shape operator of a cyclic parallel hypersurface in complex hyperbolic two-plane Grassmannians is Reeb parallel. By using this fact, we classify all cyclic parallel hypersurfaces in complex hyperbolic two-plane Grassmannians with non-vanishing geodesic Reeb flow. Next, we give a non-existence theorem for cyclic Hopf hypersurfaces in complex two-plane Grassmannians. | Lee, Hyunjin; Suh, Young Jin | Kyunypook Natl Univ, Res Inst Real & Complex Manifolds, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Math, Daegu 41566, South Korea; Kyungpook Natl Univ, RIRCM, Daegu 41566, South Korea | 55706812200; 7202260479 | lhjibis@hanmail.net;yjsuh@knu.ac.kr; | INTERNATIONAL JOURNAL OF MATHEMATICS | INT J MATH | 0129-167X | 1793-6519 | 31 | 2 | SCIE | MATHEMATICS | 2020 | 0.688 | 73.8 | 0.69 | 2025-06-25 | 5 | 4 | Hopf hypersurfaces; complex hyperbolic two-plane Grassmannians; complex two-plane Grassmannians; cyclic parallelism; Reeb parallelism | REAL HYPERSURFACES; 2-PLANE GRASSMANNIANS | complex hyperbolic two-plane Grassmannians; complex two-plane Grassmannians; cyclic parallelism; Hopf hypersurfaces; Reeb parallelism | English | 2020 | 2020-02 | 10.1142/s0129167x20500147 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Article | Melatonin inhibits vascular smooth muscle cell proliferation and apoptosis through upregulation of Sestrin2 | Excessive vascular smooth muscle cell (VSMC) proliferation contributes to the development of atherosclerosis and restenosis. Furthermore, apoptosis of VSMCs accelerates plaque rupture in the atherosclerotic vessels. Therefore, a strategy that regulates both VSMC proliferation and apoptosis is essential for the development of novel pharmacological tools for the treatment of atherosclerosis. Despite mounting evidence supporting the benefits of melatonin in diverse metabolic diseases, the role of melatonin in VSMC growth remains largely unknown. The present study revealed that melatonin inhibited both proliferation and apoptosis of primary cultured rat VSMCs. Melatonin induced mitochondrial energetic stress in VSMCs and subsequent induction of Sestrin2 via C/EBP beta. Melatonin-induced Sestrin2 suppressed mTORC1 activity in VSMCs, contributing to suppression of VSMC proliferation. Additionally, melatonin-induced upregulation of Sestrin2 blocked apoptosis by preventing excessive ROS generation. The results demonstrated that melatonin controlled VSMC proliferation and apoptosis via Sestrin2-mediated inhibition of mTORC1 and ROS scavenging. Therefore, melatonin should be considered as a lead compound for therapies aimed at preventing vessel lumen constriction during the course of atherosclerosis and restenosis. | Lee, Seunghyeong; Byun, Jun-Kyu; Park, Mihyang; Kim, Sung Woo; Lee, Sungwoo; Kim, Jung-Guk; Lee, In-Kyu; Choi, Yeon-Kyung; Park, Keun-Gyu | Kyungpook Natl Univ, Dept Biomed Sci, Grad Sch, Daegu 41566, South Korea; Kyungpook Natl Univ, BK21 Plus KNU Biomed Convergence Program, Daegu 41566, South Korea; Kyungpook Natl Univ, Res Inst Aging & Metab, Daegu 41566, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, 130 Dongdeok Ro, Daegu 41944, South Korea; Catholic Univ Daegu, Dept Internal Med, Sch Med, Daegu 42472, South Korea; Daegu Gyeongbuk Med Innovat Fdn, New Drug Dev Ctr, Daegu 41061, South Korea | ; Lee, In-Kyu/AAR-6374-2021 | exc4932@hanmail.net;kpark@knu.ac.kr; | EXPERIMENTAL AND THERAPEUTIC MEDICINE | EXP THER MED | 1792-0981 | 1792-1015 | 19 | 6 | SCIE | MEDICINE, RESEARCH & EXPERIMENTAL | 2020 | 2.447 | 73.9 | 18 | vascular smooth muscle cells; melatonin; Sestrin2; proliferation; apoptosis | MITOCHONDRIAL-FUNCTION; GENE-EXPRESSION; STRESS; ATHEROSCLEROSIS; DYSFUNCTION; ACTIVATION; FEATURES; PATHWAY | English | 2020 | 2020-06 | 10.3892/etm.2020.8638 | 바로가기 | 바로가기 | 바로가기 |
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