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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | Article | Toward Memristive Phase-Change Neural Network with High-Quality Ultra-Effective Highly-Self-Adjustable Online Learning | Memristive hardware with reconfigurable conductance levels are leading candidates for achieving artificial neural networks (ANNs). However, owing to difficulties in device character design and circuit combination, the ability to perform complicated online-learning tasks on a memristive network is not well understood. Here, tandem (T) material states are harnessed in a phase-change memory (PCM) element, i.e., the primed-amorphous state and the partial-crystallized state, by utilizing an impetus-and-consequent pair pulse through a large degree of configurational ordering, and illustrate the development of an integrated system for achieving in-memory computing and neural networks (NNs). A correct classification of 96.1% of 10,000 separate test images from the conventional Modified-National-Institute-of-Standards-and-Technology (MNIST) database in the tandem neural-network (T-NN) model is achieved, as well as image recognition for 28x28-pixel pictures. The T-NN configuration exhibits an in situ learning, with 50% of the elements stuck in the low-conductance state, and at the same time, maintains an identification accuracy of approximate to 90%. The structural origin of the large degree of configurational-ordering-enhanced improvement in the extent of the conductance uniformity in the T-based memristive element is revealed by theoretical studies. This work opens the door for attaining a widely relevant hardware system capable of performing artificial intelligence tasks with a large power-time efficacy. Memristive hardware is a promising candidate for achieving artificial neural networks (ANNs). However, the ability to perform complicated online learning tasks is not well understood. This work explores the utilization of tandem (T) material states, viz., primed-amorphous state and partial-crystallized state, in a phase-change memory (PCM) element and the design of a hybrid system for in-memory computing and ANNs. image | Lim, Kian-Guan; Go, Shao-Xiang; Tan, Chun-Chia; Jiang, Yu; Cai, Kui; Chong, Tow-Chong; Elliott, Stephen R.; Lee, Tae-Hoon; Loke, Desmond K. | Singapore Univ Technol & Design, Dept Sci Math & Technol, Singapore 487372, Singapore; Univ Oxford, Phys & Theoret Chem Lab, Oxford OX1 3QZ, England; Kyungpook Natl Univ, Sch Mat Sci & Engn, Daegu 41566, South Korea | Lee, Tae/AAB-7490-2021; Cai, Kui/AAS-9854-2021 | desmond_loke@sutd.edu.sg; | ADVANCED PHYSICS RESEARCH | ADV PHYS RES-US | 2751-1200 | 3 | 3 | ESCI | PHYSICS, APPLIED;PHYSICS, CONDENSED MATTER | 2024 | 2.8 | 46.3 | 1 | artificial neural network; image classification; in situ online learning; memristive devices; phase-change-memory materials | DEVICES; SYSTEM | English | 2024 | 2024-03 | 10.1002/apxr.202300085 | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | ○ | Article | Dynamics of SARS-CoV-2 variants during the XBB wave in the Republic of Korea | As COVID-19 has become endemic, SARS-CoV-2 variants are becoming increasingly diverse, underscoring the escalating importance of global genomic surveillance. This study analyzed 86,762 COVID-19 samples identified in the Republic of Korea from September 2022 to November 2023. The results revealed a consistent increase in the prevalence of the XBB variants following the dominance of BN.1, with various XBB sub-lineages co-circulating in the Republic of Korea. The overall nucleotide diversity (pi) among the SARS-CoV-2 genomes was 0.00155. Evolutionary analysis revealed that the average time interval between the first detection and estimated date of the most recent common ancestor of Korean XBB sub-lineages was 47 d, suggesting that the novel variants were efficiently identified in the Korean surveillance system. The mutation rate was determined to be in the range of 5.6 x 10(-4) to 9.1 x 10(-4) substitutions/site/year. In conclusion, this study provides insights into the genetic diversity and evolutionary interpretation of the XBB sub-lineages during the XBB wave in the Republic of Korea, highlighting the importance of continued genomic surveillance for emerging variants. | No, Jin Sun; Noh, Ji Yeong; Lee, Chae Young; Kim, Il-Hwan; Kim, Jeong-Ah; Ahn, Yu Jeong; Lee, Hyeokjin; Kim, Jeong-Min; Lee, Nam-Joo; Lee, Dong-Wook; Kwon, Jeong-Hoon; Rhee, Jeeeun; Kim, Eun-Jin | Korea Dis Control & Prevent Agcy, Dept Lab Diag & Anal, Div Emerging Infect Dis, Cheongju, South Korea; Kyungpook Natl Univ, Coll Vet Med, Daegu, South Korea | 57188833177; 57189463570; 57222424110; 57207979541; 57365772200; 59340889100; 57207324810; 57203325163; 55469303000; 57711484300; 59341098700; 7202839819; 57225870516 | ekim@korea.kr; | VIRUS RESEARCH | VIRUS RES | 0168-1702 | 1872-7492 | 350 | SCIE | VIROLOGY | 2024 | 2.7 | 46.4 | 0.76 | 2025-05-07 | 2 | 3 | SARS-CoV-2; COVID-19; Genomic surveillance; XBB variant | GENOMIC SURVEILLANCE; GENETIC DIVERSITY | COVID-19; Genomic surveillance; SARS-CoV-2; XBB variant | COVID-19; Evolution, Molecular; Genetic Variation; Genome, Viral; Humans; Mutation; Mutation Rate; Phylogeny; Republic of Korea; SARS-CoV-2; SARS-CoV-2 variants; adult; coronavirus disease 2019; genetic variability; genetic variation; human; mutation rate; nonhuman; prevalence; review; Severe acute respiratory syndrome coronavirus 2; South Korea; time interval; classification; epidemiology; genetic variation; genetics; isolation and purification; molecular evolution; mutation; phylogeny; South Korea; virology; virus genome | English | 2024 | 2024-12 | 10.1016/j.virusres.2024.199471 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Article | Investigation of characteristic values in TDR waveform using SHapley Additive exPlanations (SHAP) for dielectric constant estimation during curing time | As materials cure, the internal electrical flow changes, leading to variations in the dielectric constant over time. This study aims to assess the impact of voltage values extracted from time domain reflectometry (TDR) waveforms, measured during the curing of materials, on predicting the dielectric constant. The experiments are conducted over a curing period ranging from 60 to 8640 minutes, with 30 TDR trials. From the measured waveforms, values of V-0, V-1, V-2, V-f, and At are deduced. Additionally, curing time is included as an input variable. Groups A and B are distinguished based on the presence or absence of At, indicating a physical relationship between At and the dielectric constant. The dielectric constant is set as the output variable. The SHapley Additive exPlanations (SHAP) algorithm is applied to the compiled data. The results indicate that At and V-1 are the most influential input variables in both Group-A and Group-B. The study also presents the distribution of SHAP values and interacts SHAP values to infer the interrelationships among the input variables. To validate the reliability of these findings, the partial dependence (PD) algorithm is applied to estimate the marginal effects of each input variable, with outcomes closely aligning with those of the SHAP algorithm. This research suggests that understanding the contributions and proportional relationships of each input variable can aid in interpreting the relationships among various material properties. | Hong, Won-Taek; Han, Woojin; Byun, Yong-Hoon; Yoon, Hyung-Koo | Gachon Univ, Dept Civil & Environm Engn, 1342 Seongnam Daero, Seongnam Si 13120, Gyeonggi Do, South Korea; Korea Univ, Sch Civil Environm & Architectural Engn, 145 Anam Ro, Seoul 02841, South Korea; Kyungpook Natl Univ, Dept Agr Civil Engn, 80 Daehak Ro, Daegu 41566, South Korea; Daejeon Univ, Dept Construct & Disaster Prevent Engn, 62 Daehak Ro, Daejeon 34520, South Korea | Han, WooJin/KLZ-1352-2024; Byun, Yong-Hoon/JKI-8441-2023 | hyungkoo@dju.ac.kr; | SMART STRUCTURES AND SYSTEMS | SMART STRUCT SYST | 1738-1584 | 1738-1991 | 34 | 1 | SCIE | ENGINEERING, CIVIL;ENGINEERING, MECHANICAL;INSTRUMENTS & INSTRUMENTATION | 2024 | 2.2 | 46.4 | 1 | curing time; feature contribution; partial dependence (PD) algorithm; SHapley Additive exPlanations (SHAP) algorithm; time domain reflectometry (TDR) | SOIL-WATER CONTENT; ELECTRICAL-CONDUCTIVITY; NEURAL-NETWORK; DEEP | English | 2024 | 2024-07 | 10.12989/sss.2024.34.1.017 | 바로가기 | 바로가기 | 바로가기 | |||||||||
| ○ | ○ | Article | Real-time estimation of responses and loads of real-scale pipes subjected to earthquakes and external loads using digital twin technology | Infrastructure facilities contain various pipe systems, which can be considerably damaged by external loads such as earthquakes. Therefore, structural health monitoring (SHM) and safety assessment of pipes are crucial. Digital twin technology for SHM of pipes is important in the industry. This study proposes a digital twin system that estimates the behavior, stress, and external load of real -scale pipes in real time under simultaneous seismic and external loads using a minimum number of sensors. Vibration tests were performed to construct the digital twin system, and a numerical model was developed that considered the dynamic characteristics of a target pipe. Moreover, a reduced -order modeling technique of a numerical model was applied to enhance its real-time performance. The digital twin system successfully estimated the response of the pipe at all points. Verification of the digital twin system was performed by comparing it with the experimental parameters of a real -scale pipe. The proposed digital twin system can help enhance SHM and system's maintenance. | Kim, Dongchang; Kwag, Shinyoung; Chang, Sung-Jin; Eem, Seunghyun | Kyungpook Natl Univ, Sch Convergence & Fus Syst Engn, 80 Daehak Ro, Daegu 41566, South Korea; Hanbat Natl Univ, Dept Civil & Environm Engn, 125 Dongseo Daero, Daejeon 34158, South Korea; Pusan Natl Univ, Seism Res & Test Ctr, 49 Busandaehak Ro, Yangsan 50612, South Korea | ; Eem, Seunghyun/KVB-1493-2024 | 58487965700; 55779491500; 55494267900; 52363442900 | skwag@hanbat.ac.kr;eemsh@knu.ac.kr; | SMART STRUCTURES AND SYSTEMS | SMART STRUCT SYST | 1738-1584 | 1738-1991 | 33 | 5 | SCIE | ENGINEERING, CIVIL;ENGINEERING, MECHANICAL;INSTRUMENTS & INSTRUMENTATION | 2024 | 2.2 | 46.4 | 0 | 2025-05-07 | 0 | 0 | digital twin; pipe system; real time; reduced-order modeling; structural health monitoring | FIR FILTER; IDENTIFICATION; PIPELINES; DESIGN; LIQUID; SYSTEM; DAMAGE | digital twin; pipe system; real time; reduced-order modeling; structural health monitoring | Earthquakes; Numerical models; Earthquake load; External loads; Health safety; Monitoring assessment; Pipe system; Real- time; Real-time estimation; Reduced order modelling; Reduced-order model; Safety assessments; Structural health monitoring | English | 2024 | 2024-05 | 10.12989/sss.2024.33.5.375 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Article | Soil resistance estimation using smart instrumented dynamic penetrometers | In-situ penetration tests using dynamic penetrometers are widely used for estimating soil resistance. Additionally, these dynamic penetrometers have been instrumented to improve tests accuracy. This paper introduces smart instrumented dynamic penetrometers and discusses experimental studies for various cases. An energy monitoring module was developed to enhance the dynamic penetration tests. The standard penetration test (SPT) and instrumented dynamic cone penetrometer (IDCP) tests were conducted using the energy monitoring module. Dynamic responses obtained by the energy monitoring module were used to calculate the transferred energies into the rod head and tip to correct the evaluation of ground strength. In addition, a crosshole-type dynamic penetrometer (CDP) was developed to measure the penetration index and shear wave velocity simultaneously to estimate the strength and stiffness of ground. The results of this study indicate that smart instrumented dynamic penetrometers may be effectively used to characterize the strength and stiffness of ground. | Park, Geunwoo; Kim, Namsun; Byun, Yong-Hoon; Kim, Sang Yeob; Lee, Jong-Sub | Korea Univ, Sch Civil Environm & Architectural Engn, 145 Anam Ro, Seoul 02841, South Korea; Kyungpook Natl Univ, Dept Agr Civil Engn, 80 Daehak Ro, Daegu 41566, South Korea; Konkuk Univ, Dept Fire & Disaster Prevent, 268 Chungwon Daero, Chungju Si 27478, Chungcheongbuk, South Korea | Lee, Jong-Sub/G-2752-2012; Byun, Yong-Hoon/JKI-8441-2023 | jongsub@korea.ac.kr; | SMART STRUCTURES AND SYSTEMS | SMART STRUCT SYST | 1738-1584 | 1738-1991 | 34 | 1 | SCIE | ENGINEERING, CIVIL;ENGINEERING, MECHANICAL;INSTRUMENTS & INSTRUMENTATION | 2024 | 2.2 | 46.4 | 0 | Crosshole-type Dynamic Penetrometer (CDP); energy monitoring module; Instrumented Dynamic Cone Penetrometer (IDCP); Standard Penetration Test (SPT); Transferred energy | CONE PENETROMETER; STRENGTH PARAMETERS; ROD | English | 2024 | 2024-07 | 10.12989/sss.2024.34.1.051 | 바로가기 | 바로가기 | 바로가기 | |||||||||
| ○ | ○ | Article | Bioanalysis of ursodeoxycholic acid and its metabolites and improved oral bioavailability using mixed micelles with poloxamer 407 and polysorbate 80 | The development of analytical methods for endogenous therapeutic substances is a critical but challenging issue as obtaining a blank matrix without endogenous substance is impossible. To address this issue, we prepared a surrogate biological matrix by removing endogenous bile acids from rat plasma using a charcoal-stripped method and developed an analytical method for ursodeoxycholic acid (UDCA) and its conjugated metabolites, tauroursodeoxycholic (TUDCA) and glycoursodeoxycholic acid (GUDCA), including the use of surrogate matrices and protein precipitation method. In addition, we applied the bioanalytical method to investigate the bioavailability of UDCA-mixed micelle powder formulation (UDCA-MM). The oral bioavailability of UDCA in rats was calculated as 15.2% and increased 3.32-fold following the oral administration of UDCA-MM with the increased production of TUDCA without significant change in GUDCA. The UDCA-MM powder was prepared by thin-layer hydration and subsequent freeze-drying method in a ratio of UDCA/polysorbate 80/poloxamer 407 = 1:1:10 (w/w/w). The UDCA-MM was easily dispersed with a particle size of 16.5 +/- 2.2 nm and solubility of 1120 +/- 38 mu g/mL, which represented a 175.3-fold increase in its solubility of UDCA. In conclusion, we developed and validated a simple and reliable bioanalytical method for UDCA, TUDCA, and GUDCA using the charcoal-stripped plasma as surrogate matrices. Our bioanalytical method successfully supported the assessment of the pharmacokinetics or bioavailability of UDCA, TUDCA, and GUDCA after the intravenous or oral dosing of UDCA and UDCA-MM. The UDCA-MM using poloxamer 407 and polysorbate 80 is a promising technique for increasing the solubility and oral absorption of UDCA. | Jeon, So Yeon; Lee, Chul Haeng; Lee, Jihoon; Jeon, Ji-Hyeon; Jin, Yelim; Song, Im-Sook; Choi, Min-Koo | Dankook Univ, Coll Pharm, Cheonan 31116, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Vessel Organ Interact Res Ctr VOICE, Coll Pharm,FOUR Community Based Intelligent Novel, Daegu 41566, South Korea | 57226815842; 57219051827; 57195979045; 57204685946; 58926401500; 7201564500; 8695781400 | isssong@knu.ac.kr;minkoochoi@dankook.ac.kr; | BIOTECHNOLOGY AND BIOPROCESS ENGINEERING | BIOTECHNOL BIOPROC E | 1226-8372 | 1976-3816 | 29 | 2 | SCIE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | 2024 | 3 | 46.6 | 0.43 | 2025-05-07 | 2 | 2 | Ursodeoxycholic acid; Surrogate biological matrix; Charcoal-stripped method; Pharmacokinetics; Mixed micelle formulation | BILE-ACIDS; PHOSPHOLIPID COMPLEX; LIVER; FORMULATION; GLYCINE; DOXORUBICIN; DELIVERY; HEALTHY; SERUM; MODEL | Charcoal-stripped method; Mixed micelle formulation; Pharmacokinetics; Surrogate biological matrix; Ursodeoxycholic acid | Biochemistry; Charcoal; Metabolites; Micelles; Particle size; Precipitation (chemical); Solubility; charcoal; poloxamer; polysorbate 80; taurursodiol; ursodeoxycholic acid; Bioanalytical methods; Biological matrixes; Charcoal-stripped method; Mixed micelle formulation; Mixed micelles; Oral bioavailabilities; Poloxamer 407; Polysorbate 80; Surrogate biological matrix; Ursodeoxycholic acid; animal experiment; Article; controlled study; drug bioavailability; drug formulation; freeze drying; hydration; liquid chromatography-mass spectrometry; male; micelle; nonhuman; oral absorption; particle size; plasma concentration-time curve; powder; rat; Sprague Dawley rat; transmission electron microscopy; Pharmacokinetics | English | 2024 | 2024-04 | 10.1007/s12257-024-00064-y | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Review | Natural products ameliorating the adverse health effects by air particulate matter | The threats of air pollution mediated by particulate matter (PM) to human health are severe burdens to modern society. For example, PM is inhaled in the lungs or affects keratinocytes to induce reactive oxygen species that exert oxidative stress, inflammatory responses, and genotoxicity. Natural products are rich sources of the antioxidant and anti-inflammatory chemicals that might counteract what PM does in the human body. This review provides a compilation of knowledge on bioactive natural products that improve the health conditions from PM-induced health outcomes. The natural products were classified according to biosynthetic origins or resources: phenolic compounds including flavonoids and other phenolics, terpenoids, steroids, phytochemicals from marine algae, statins, lipids, alkaloids, and other nitrogen-containing natural products. This review article covers the structures and biological activity of natural products investigated with tissue cells or animal models. © The Author(s), under exclusive licence to The Korean Society for Biotechnology and Bioengineering and Springer-Verlag GmbH Germany, part of Springer Nature 2024. | Hahn, Dongyup; Kim, Min Jeong; Kwon, Yun; Kim, Eunjeong; Park, Dong Ho; Bae, Jong-Sup | School of Food Science and Biotechnology, College of Agriculture and Life Sciences, Kyungpook National University, Daegu, 41566, South Korea, Department of Integrative Biotechnology, Kyungpook National University, Daegu, 41566, South Korea; School of Food Science and Biotechnology, College of Agriculture and Life Sciences, Kyungpook National University, Daegu, 41566, South Korea; College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, 41566, South Korea; Department of Biology, College of Natural Sciences, Kyungpook National University, Daegu, 41566, South Korea; Department of Ophthalmology, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, 41944, South Korea; College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, 41566, South Korea | 36554163400; 57215818497; 56156932300; 56892981600; 36676632900; 16021543200 | baejs@knu.ac.kr; | Biotechnology and Bioprocess Engineering | BIOTECHNOL BIOPROC E | 1226-8372 | 1976-3816 | 29 | 1 | SCIE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | 2024 | 3 | 46.6 | 0.19 | 2025-05-07 | 4 | Air pollution; Natural products; Particulate matter; Pulmonary diseases; Skin diseases | Algae; Bioactivity; Health risks; Lipids; Particles (particulate matter); Pulmonary diseases; alkaloid; flavonoid; hydroxymethylglutaryl coenzyme A reductase inhibitor; lipid; natural product; nitrogen; phenol derivative; phytochemical; polysaccharide; steroid; terpenoid; Adverse health effects; Air particulate matters; Genotoxicities; Human health; Inflammatory response; Keratinocytes; Natural products; Particulate Matter; Reactive oxygen species; Skin disease; adverse event; biological activity; health hazard; human; lung disease; marine alga; nonhuman; particulate matter; phytochemistry; Review; skin disease; Air pollution | English | Final | 2024 | 10.1007/s12257-024-00012-w | 바로가기 | 바로가기 | 바로가기 | |||||||
| ○ | ○ | Article | Reachable set estimation and H∞ performance for delayed fuzzy multi-agent systems under false data injection attacks | Addressed in this paper is the reachable set estimation (RSE) problem for fuzzy-model based leader-follower multi-agent systems with time-varying delays and false data injection attacks. First, the aperiodic sampled-data control is designed for the follower agents with randomly occurring false data injection attacks. Then, using the Kronecker product, the error system between the leader and the follower is obtained in a compact general form. Next, a novel Lyapunov-Krasovskii functional is constructed with the knowledge of sampling patterns and time-varying delays. In the framework of linear matrix inequalities, sufficient consensus conditions are determined from the H-infinity performance index and Lyapunov theory to guarantee that its reachable set is enclosed by an ellipsoid in the existence of bounded perturbations. In the end, the Duffing Van der Pol oscillator and the single-link robot arm models are employed to validate the derived theoretical results. | Visakamoorthi, B.; Subramanian, K.; Muthukumar, P.; Yu, S. S.; Trinh, H.; Lee, Tae H. | Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu, South Korea; Deakin Univ, Fac Sci Engn & Built Environm, Sch Engn, Geelong, Australia; Gandhigram Rural Inst Deemed Univ, Dept Math, Gandhigram 624302, Tamil Nadu, India; Jeonbuk Natl Univ, Div Elect Engn, Jeonju, South Korea | Lee, TaeHee/I-3043-2019; Balasubramani, Visakamoorthi/GPT-2286-2022; P, Muthukumar/M-8127-2018; YU, Samson/R-4063-2019; K, Subramanian/ABC-4640-2021 | 57219385877; 59235825700; 24475116900; 59319278400; 7005816677; 56678696600 | pmuthukumargri@gmail.com; | IET CONTROL THEORY AND APPLICATIONS | IET CONTROL THEORY A | 1751-8644 | 1751-8652 | 18 | 16 | SCIE | AUTOMATION & CONTROL SYSTEMS;ENGINEERING, ELECTRICAL & ELECTRONIC;INSTRUMENTS & INSTRUMENTATION | 2024 | 2.3 | 46.6 | 1.54 | 2025-05-07 | 5 | 6 | false data injection attacks; fuzzy multi-agent systems; linear matrix inequality; Lyapunov-Krasovskii functional; reachable set bounding; sampled-data control | TIME-VARYING DELAYS; CONSENSUS CONTROL | false data injection attacks; fuzzy multi-agent systems; linear matrix inequality; Lyapunov-Krasovskii functional; reachable set bounding; sampled-data control | Circuit oscillations; Lyapunov functions; Multi agent systems; Robustness (control systems); Sampled data control systems; Time delay; Time varying control systems; Estimation problem; False data injection attacks; Fuzzy multi-agent system; H ∞ performance; Linear matrix in equalities; Lyapunov-Krasovskii's functional; Reachable set; Reachable set bounding; Sampled-data control; Time-varying delay; Linear matrix inequalities | English | 2024 | 2024-11 | 10.1049/cth2.12606 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Suppressive activities of lupeol on sepsis mouse model | Sepsis is a life-threatening condition triggered by the body's extreme response to an infection, leading to widespread inflammation, organ dysfunction, and potentially fatal complications. While lupeol, a significant phytosterol found in various herbal plants, has been considered as a potential anti-cancer agent, its anti-septic activities and underlying molecular mechanisms remain unclear. The aim of this study is to investigate the effects of lupeol on a cecal ligation and puncture (CLP)-induced septic mouse model. Animals were categorized into six groups: control, CLP-operated, CLP plus maslinic acid, and CLP plus lupeol (0.5, 1, or 2 mg/kg). The assessment included survival rate, body weight changes, inflammatory cytokines, and histological analyses. Additionally, human endothelial cells were stimulated with high mobility group box1 (HMGB1) protein and lupeol, with cell viability determined. Inflammatory markers and gene expression were evaluated through enzymelinked immunosorbent assay and Western blot analysis, respectively. After CLP surgery, the group treated with lupeol showed improved survival rates and body weight compared to the untreated control group. Lupeol treatment also decreased levels of tumor necrosis factor (TNF)-alpha, interleukin-1 beta, nitric oxide, and cytokines associated with kidney inflammation. When administered to HMGB1-activated cells, lupeol reduced the expression of Toll-like receptor 4 and TNF-alpha, while simultaneously activating phosphoinositide 3-kinase/AKT signaling to enhance cell survival. In conclusion, lupeol demonstrated anti-inflammatory properties and conferred protective effects against CLP-induced sepsis, reinforcing cell survival in the face of septic responses. | Cho, Sanghee; Park, Yun Jin; Lee, Jinhee; Bae, Jong-Sup | Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, Daegu 41566, South Korea | 58784915200; 58784741900; 59150416200; 16021543200 | baejs@knu.ac.kr; | BIOTECHNOLOGY AND BIOPROCESS ENGINEERING | BIOTECHNOL BIOPROC E | 1226-8372 | 1976-3816 | 29 | 5 | SCIE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | 2024 | 3 | 46.6 | 0 | 2025-05-07 | 1 | 1 | Lupeol; Cecal ligation and puncture; Sepsis; Kidney injury; Inflammation | ANIMAL-MODELS; IMMUNOSUPPRESSION | Cecal ligation and puncture; Inflammation; Kidney injury; Lupeol; Sepsis | Anthropometry; Cell death; Cell signaling; Electrophoresis; Endothelial cells; Macrophages; Nitric oxide; Pathology; Plants (botany); cytokine; high mobility group B1 protein; interleukin 1beta; lupeol; maslinic acid; nitric oxide; toll like receptor 4; tumor necrosis factor; Body weight; Cecal ligation and puncture; High-mobility groups; Inflammation; Kidney injury; Lupeol; Mice models; Sepsis; Survival rate; Tumor necrosis factors; animal experiment; animal model; animal tissue; antiinflammatory activity; Article; body weight; body weight change; cecal ligation and puncture-induced sepsis; cell survival; cell viability; cell viability assay; controlled study; enzyme linked immunosorbent assay; gene expression; hepatitis; histopathology; human; human cell; in vitro study; mouse; nephritis; nonhuman; Pi3K/Akt signaling; sepsis; survival rate; Western blotting; Gene expression | English | 2024 | 2024-10 | 10.1007/s12257-024-00112-7 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Growth and characterization of ⁶LiI:Ag crystal scintillators for thermal and epithermal neutron detection on the lunar surface | This paper discusses crystal growth and characterization of 1.0-inch (LiI)-Li-6:Ag scintillators for thermal and epithermal neutron detection on the lunar surface as part of the Lunar Vehicle Radiation Dosimeter project. Zone purification method was employed to purify the raw material of (LiI)-Li-6, and the crystals were grown using the Bridgman method. X-ray luminescence spectrum was measured to confirm the presence of Ag+ in the crystal lattice of (LiI)-Li-6. The feasibility of neutron detection under Cf-252 fast neutron irradiation was investigated. A hydrogen-rich paraffin wax moderator was used to slow down fast neutrons to obtain thermal and epithermal neutrons. The charge comparison method was used to perform pulse shape discrimination. The maximum value of the Figure of Merit was obtained to be 1.3, which demonstrates the capability of using (LiI)-Li-6:Ag crystal scintillators in high neutron and gamma mixed fields. The energy resolution of the thermal neutron peak varied with the thickness of scintillators, achieving 12.0 % for the 0.5 cm thick samples. The potential for further improvement of the scintillation performance of (LiI)-Li-6:Ag crystal relies on reducing impurities and color centers. | Quang, Nguyen Duy; Vuong, Phan Quoc; Luan, Nguyen Thanh; Truc, Lam Tan; Ton, Nguyen Duc; Kang, S. C.; Park, Hwanbae; Nam, Uk-Won; Park, Won-Kee; Sohn, Jongdae; Choi, Young -Jun; Youn, Sukwon; Ye, Sung -Joon; Kim, Sunghwan; Kim, Hongjoo | Kyungpook Natl Univ, Dept Phys, Daegu 41566, South Korea; Korea Astron & Space Sci Inst, Space Sci Div, Daejeon 34055, South Korea; Seoul Natl Univ, Dept Appl Bioengn, Seoul 08826, South Korea; Cheongju Univ, Dept Radiol Sci, Cheongju 28503, South Korea | ; Choi, Jong/L-6893-2019 | 57223004024; 57207618553; 57210576969; 58303266600; 57966935300; 57191418531; 35086680500; 6602840978; 35285730800; 55193404200; 55685945500; 57210900037; 7202088315; 36165569900; 59051568100 | hongjoo@knu.ac.kr; | JOURNAL OF CRYSTAL GROWTH | J CRYST GROWTH | 0022-0248 | 1873-5002 | 635 | SCIE | CRYSTALLOGRAPHY;MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED | 2024 | 2 | 46.8 | 0.38 | 2025-05-07 | 2 | 1 | Scintillation neutron detector; Crystal growth; Pulse shape discrimination; Lunar surface radiation; (LiI)-Li-6:Ag crystal | EU2+ ACTIVATION; IODIDE | <sup>6</sup>LiI:Ag crystal; Crystal growth; Lunar surface radiation; Pulse shape discrimination; Scintillation neutron detector | Crystal growth from melt; Crystal impurities; Crystal structure; Ionization; Neutron detectors; Neutron irradiation; Neutrons; Scintillation counters; 6LiI:ag crystal; Crystal scintillators; Epithermal neutron; Lunar surface; Lunar surface radiation; Neutron detection; Pulse shape discrimination; Scintillation neutron detector; Surface radiation; Thermal neutrons; Scintillation | English | 2024 | 2024-06-01 | 10.1016/j.jcrysgro.2024.127692 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Long-term outcomes of CNS WHO grade 2 oligodendroglioma in adult patients: a single-institution experience | Purpose Oligodendrogliomas (ODGs) are a subtype of diffuse lower-grade gliomas with overall survival of > 10 years. This study aims to analyze long-term outcomes and identify prognostic factors in patients with WHO grade 2 ODG. Methods We retrospectively reviewed 138 adult patients diagnosed with 1p/19q co-deleted ODG who underwent surgical resection or biopsy between 1994 and 2021, analyzing clinical data, treatment details, and outcomes. Progression-free survival (PFS) and overall survival (OS) were evaluated using Kaplan-Meier analysis. Univariate and multivariate Cox regression analyses were utilized to identify significant prognostic factors. Results In the gross total resection (GTR) group, 63 (45.7%) underwent observation and 5 (3.6%) received postoperative treatment; in the non-GTR group, 37 (26.8%) were observed and 33 (23.9%) received postoperative treatment. The median PFS and OS were 6.8 and 18.4 years, respectively. Between adjuvant treatment and observation, there was no significant difference in PFS or OS. However, GTR or STR with less than 10% residual tumor exhibited significantly better PFS and OS compared to PR or biopsy (p = 0.022 and 0.032, respectively). Multivariate analysis revealed that contrast enhancement on MRI was associated with worse PFS (HR = 2.36, p < 0.001) and OS (HR = 5.89, p = 0.001). And the presence of seizures at presentation was associated with improved OS (HR = 0.28, p = 0.006). Conclusion This study underscores favorable long-term outcomes for patients with 1p/19q co-deleted ODG WHO grade 2. Our findings indicate that the EOR plays a crucial role as a significant prognostic factor in enhancing PFS and OS outcomes in WHO grade 2 ODG. | Byeon, Yukyeng; Lee, Chaejin; Jeon, Juhee; Kim, Gung Ju; Chong, Sangjoon; Kim, Young-Hoon; Cho, Young Hyun; Hong, Seok Ho; Hong, Chang-Ki; Kim, Jeong Hoon; Song, Sang Woo | Univ Ulsan, Coll Med, Asan Med Ctr, Dept Neurol Surg, 88 Olymp Ro 43 Gil, Seoul 05505, South Korea; Kyungpook Natl Univ Hosp, Dept Neurosurg, Daegu 41944, South Korea | Cho, Young/AAV-8697-2021; Kim, Young Hoon/F-5424-2012 | 56183790500; 57211989339; 58906037300; 58905520300; 37664614800; 58304779800; 55472215500; 57203319535; 57208356870; 57201965829; 55104329100 | naitk14@gmail.com;cjleee01@gmail.com;doctorjuhee88@gmail.com;wntnotchsrc@gmail.com;neurosj@gmail.com;justin527@hanmail.net;yhyunc@amc.seoul.kr;hongsound@amc.seoul.kr;changki.hong@amc.seoul.kr;jhkim1@amc.seoul.kr;his4u2@hanmail.net; | DISCOVER ONCOLOGY | DISCOV ONCOL | 2730-6011 | 15 | 1 | SCIE | ENDOCRINOLOGY & METABOLISM;ONCOLOGY | 2024 | 2.9 | 46.8 | 0.5 | 2025-05-07 | 1 | 1 | Oligodendroglioma; 1p/19q codeletion; Extent of resection; Observation; Survival | CENTRAL-NERVOUS-SYSTEM; ANAPLASTIC OLIGODENDROGLIOMA; PLUS PROCARBAZINE; UNITED-STATES; PRIMARY BRAIN; TUMORS; SURVIVAL; THERAPY; CLASSIFICATION; CHEMOTHERAPY | 1p/19q codeletion; Extent of resection; Observation; Oligodendroglioma; Survival | carboplatin; etoposide; ifosfamide; lomustine; procarbazine; temozolomide; vincristine; adult; aged; Article; astrocytoma; cancer grading; cancer prognosis; cancer staging; cancer surgery; central nervous system tumor; clinical outcome; excision; female; follow up; glioblastoma; grade 2 oligodendroglioma; headache; human; human tissue; immunohistochemistry; long term outcome; major clinical study; male; neuroimaging; nuclear magnetic resonance imaging; oligodendroglioma; overall survival; postoperative care; progression free survival; retrospective study; risk factor; seizure; single institution experience; tumor growth; tumor volume | English | 2024 | 2024-07-06 | 10.1007/s12672-024-01136-4 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Nanomedicine mediated thyroid cancer diagnosis and treatment: an approach from generalized to personalized medicine | Thyroid cancer (TC) being the common endocrine malignancy is glooming steadily due to its poor prognosis. The treatment strategies of surgery, radiotherapy, and conventional chemotherapy are providing unsatisfactory output. However, combination therapy can negotiate the worse prognosis to the better, where chemoradiotherapy, radiotherapy with surgery, or dual chemotherapeutic drugs are being glorified. Chemotherapy includes the use of doxorubicin or taxanes generally with platinum-based drugs viz. cisplatin or carboplatin that are administered alone or along with multitarget tyrosine kinase inhibitors viz. Lenvatinib, Sorafenib, Sunitinib, Vandetanib, Pyrazolo-pyrimidine compounds, etc., single target tyrosine kinase inhibitors like Dabrafenib plus Trametinib and Vemurafenib against BRAF, Gefitinib against EGFR, Everolimus against mTOR, vascular disruptors like Fosbretabulin, and immunotherapy with viz. Spartalizumab and Pembrolizumab, are anti-PD-1/PD-L1 molecules. Hence, several trials are currently evaluating the possible beneficial role of combinatorial therapy in TC. Since TC is the outcome of multiple genetic alterations, it necessitates targeting the multiple factors in a single shot. These combination strategies for systemically delivering therapeutic drugs seem feasible only with the help of theranostic. To date, nanoparticle-based drug delivery systems (NDDS) have devoted themselves to diagnosis, bioimaging, imaging-assisted surgery, and therapy with high success rates. The ease of handling hybrid technologies is also selectively admirable. However, in this review, we have summarized the sequential progression of chemotherapeutic drugs to NDDS designed for Personalized Medicine (PM) against TC. Personalized medicine is an ever-growing field that will be explored in future discoveries in biomedicine, particularly cancer theranostics. Hence, our review presents a closer view of NDDS as a personalized treatment for TC. We have also discussed the primary challenges facing NDDS in meeting excellence in PM. | Gulwani, Deepak; Upadhyay, Priyanka; Goel, Ridhima; Sarangthem, Vijaya; Singh, Thoudam Debraj | All India Inst Med Sci, Dept Med Oncol Lab, New Delhi, India; All India Inst Med Sci, Dept Pathol, New Delhi, India; Kyungpook Natl Univ, Cell & Matrix Res Inst, Sch Med, Dept Biochem & Cell Biol, Daegu 41944, South Korea | Sarangthem, Vijaya/AAX-7421-2020 | 58099926300; 57189309990; 57205099421; 56001741200; 55190689800 | debraj.thoudam@gmail.com; | DISCOVER ONCOLOGY | DISCOV ONCOL | 2730-6011 | 15 | 1 | SCIE | ENDOCRINOLOGY & METABOLISM;ONCOLOGY | 2024 | 2.9 | 46.8 | 0.51 | 2025-05-07 | 3 | 3 | Thyroid cancer; Personalized medicine; Nanotheranostic; Anaplastic | SODIUM/IODIDE SYMPORTER EXPRESSION; PHASE-II; IN-VITRO; NANOPARTICLES; DELIVERY; NANOTHERANOSTICS; CARCINOMA; ULTRASOUND; THERANOSTICS; CHEMOTHERAPY | Anaplastic; Nanotheranostic; Personalized medicine; Thyroid cancer | carboplatin; cisplatin; dabrafenib; doxorubicin; epidermal growth factor receptor; everolimus; fosbretabulin tromethamine; gefitinib; lenvatinib; mammalian target of rapamycin; nanoparticle; pembrolizumab; programmed death 1 ligand 1; sorafenib; spartalizumab; sunitinib; trametinib; vandetanib; vemurafenib; cancer diagnosis; chemoradiotherapy; controlled study; diagnosis; doublet chemotherapy; drug combination; drug delivery device; drug delivery system; drug therapy; human; nanomedicine; personalized medicine; pharmacology; review; therapy; thyroid cancer | English | 2024 | 2024-12-18 | 10.1007/s12672-024-01677-8 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Optical properties of pure and Sn-doped β-Ga2O3 single crystals grown by optical float zone technique | High-quality single crystals of both pure and Sn:beta-Ga2O3 single crystals were grown using the optical floating zone technique and a comprehensive study of its luminescence and scintillation properties was carried out. The pure and Sn:beta-Ga2O3 grown crystals were oriented along (1 00) by Laue diffraction pattern and its monoclinic structure was confirmed using a single crystal XRD. X-ray induced luminescence spectrum shows a maximum emission peak at 365 nm. The cut off wavelength was observed around 258 nm and the optical band gap was calculated to be 4.64 eV from UV-Vis-NIR transmission spectroscopy. The room temperature Raman spectra were recorded and the various vibration modes were investigated. Low temperature (10 to 300 K) and high temperature (325 to 675 K) TL measurements were carried out on X-ray irradiated crystals and its TL kinetic parameters such as activation energy (eV) and frequency factor (S) were calculated. Scintillation decay time profiles were measured for both pure and Sn-doped crystals under 137Cs gamma-ray excitation. The calculated scintillation light output is 2300 Ph/5.5 Mev for Sn:beta-Ga2O3 crystal under alpha-particle excitation from 241Am radiation source. | Vijayakumar, P.; Daniel, D. Joseph; Suganya, M.; Quang, Nguyen Duy; Kim, H. J. | Indira Gandhi Ctr Atom Res, Mat Sci Grp, Kalpakkam 603102, India; Kyungpook Natl Univ, Ctr High Energy Phys, Daegu 41566, South Korea; Acad Sinica, Inst Phys, Taipei, Taiwan | Kim, Hong Joo/AAE-1178-2022 | 56760469300; 55235066800; 57427476800; 58505210200; 59051568100 | hongjoo@knu.ac.kr; | JOURNAL OF CRYSTAL GROWTH | J CRYST GROWTH | 0022-0248 | 1873-5002 | 634 | SCIE | CRYSTALLOGRAPHY;MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED | 2024 | 2 | 46.8 | 2.69 | 2025-05-07 | 9 | 10 | A. Single crystal; B. X-ray diffraction; C. X-ray luminescence; D. Thermoluminescence | TRANSPARENT; SCINTILLATION; ABSORPTION | A. Single crystal; B. X-ray diffraction; C. X-ray luminescence; D. Thermoluminescence | Activation energy; Crystal structure; Energy gap; Gallium compounds; Gamma rays; Optical properties; Scintillation; Temperature; Thermoluminescence; A single crystal; C X-ray luminescence; D thermoluminescence; Float zones; High quality single crystals; Optical floating zones; Optical-; Sn-doped; X ray luminescence; [B] X-ray diffraction; Single crystals | English | 2024 | 2024-05-15 | 10.1016/j.jcrysgro.2024.127676 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Personalized, tumor-informed, circulating tumor DNA assay for detecting minimal residual disease in non-small cell lung cancer patients receiving curative treatments | Background: Circulating tumor DNA (ctDNA) has emerged as a prognostic and predictive biomarker for detection of minimal residual disease (MRD), monitoring treatment response, and early detection of recurrence in cancer patients. In this study, we explored the utility of ctDNA-based MRD detection to predict recurrence in a real-world cohort of primarily early-stage non-small cell lung cancer (NSCLC) patients treated with curative intent. Methods: Longitudinal plasma samples were collected post curative-intent treatment from 36 patients with stage I-IV NSCLC. A personalized, tumor-informed assay was used to detect and quantify ctDNA in plasma samples. Results: Of the 24 patients with plasma samples available during the MRD window (within 6 months of curative surgery and before adjuvant therapy), ctDNA was detectable in two patients. Patients with ctDNA-positivity during the MRD window were 15 times more likely to recur compared to ctDNA-negative patients (HR: 15.0, 95% CI: 1.0-253.0, p = 0.010). At any time post-curative intent treatment, ctDNA-positivity was associated with significantly poorer recurrence-free survival compared to persistently ctDNA-negative patients (p < 0.0001). Conclusion: Our real-world data indicate that longitudinal, personalized, tumor-informed ctDNA monitoring is a valuable tool in patients with NSCLC receiving curative treatment to identify patients at high risk for recurrence. | Oh, Youjin; Yoon, Sung Mi; Lee, Jeeyeon; Park, Joo Hee; Lee, Soowon; Hong, Timothy; Chung, Liam Il-young; Sudhaman, Sumedha; Riddell, Timothy; Palsuledesai, Charuta C.; Krainock, Michael; Liu, Minetta C.; Chae, Young Kwang | Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA; John H Stroger Hosp Cook Cty, Dept internal Med, Chicago, IL USA; Albert Einstein Coll Med, North Cent Bronx Hosp, Bronx, NY USA; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Daegu, South Korea; Baylor Univ, Waco, TX USA; Natera Inc, Austin, TX USA; Northwestern Univ, Feinberg Sch Med, Dept Internal Med Hematol & Oncol, 645 N Michigan Ave, Suite 1006, Chicago, IL 60611 USA | Chung, Liam Il-Young/IQU-0821-2023 | 58461465600; 58019402300; 37079213100; 58019263900; 58891221400; 58892357400; 58018988700; 55744245000; 58973710300; 30567491400; 57189069383; 9232458100; 55664764400 | ychae@nm.org; | THORACIC CANCER | THORAC CANCER | 1759-7706 | 1759-7714 | 15 | 13 | SCIE | ONCOLOGY;RESPIRATORY SYSTEM | 2024 | 2.3 | 46.8 | 2.21 | 2025-05-07 | 3 | 6 | biomarker; ctDNA; lung cancer; molecular residual disease; prognosis | RECURRENCE | biomarker; ctDNA; lung cancer; molecular residual disease; prognosis | Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Circulating Tumor DNA; Female; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm, Residual; Precision Medicine; Prognosis; antineoplastic agent; circulating tumor DNA; osimertinib; circulating tumor DNA; tumor marker; adult; aged; Article; blood sampling; cancer adjuvant therapy; cancer recurrence; cancer survival; clinical article; cohort analysis; DNA determination; drug effect; early cancer; female; high risk patient; human; longitudinal study; lung surgery; male; minimal residual disease; non small cell lung cancer; personalized medicine; recurrence free survival; retrospective study; treatment planning; blood; genetics; lung tumor; middle aged; minimal residual disease; non small cell lung cancer; pathology; procedures; prognosis; tumor recurrence; very elderly | English | 2024 | 2024-05 | 10.1111/1759-7714.15281 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Real-world outcome of crizotinib for anaplastic lymphoma kinase-positive lung cancer: Multicenter retrospective analysis in South Korea | BackgroundAbout 3%-5% of non-small cell lung cancer (NSCLC) presents positive anaplastic lymphoma kinase (ALK). Recently, several target agents have been approved as a treatment for ALK-positive NSCLC. This study aimed to analyze the real-world efficacy and outcome when administered crizotinib, the first approved target agent for ALK-positive NSCLC, according to first- or late-line treatment.MethodsA total of 290 patients with ALK-positive advanced NSCLC who were treated with crizotinib in 15 institutions in South Korea from January 2009 to December 2018 were enrolled.ResultsThe median age of patients was 57.0 years, and 50.3% were male. The median follow-up duration was 29.3 months. Among them, 113 patients received crizotinib as first-line therapy. The objective response rate (ORR) was 60.1% (57.0% for first-line recipients, 61.8% for second-/later-line). Median (95% CI) progression-free survival (PFS) was 13.7 (11.6-17.0) months. For first-line recipients, overall survival (OS) was 26.3 (17.6-35.0) months. No significant difference in ORR, PFS and OS, according to the setting of crizotinib initiation, was observed. In a multivariate Cox regression analysis, old age, male gender, initially metastatic, and number of metastatic organs were associated with poor PFS and OS. The most common adverse events were nausea and vomiting, and severe adverse event leading to dose adjustment was hepatotoxicity.ConclusionsORR, PFS, OS, and adverse event profiles were comparable to previous clinical trials. Our findings could aid in the efficient management of ALK-positive lung cancer patients. image | Jeon, Da Som; Park, Cheol-kyu; Kim, Seung Joon; Park, Chan Kwon; Chang, Yoon Soo; Jung, Chi Young; Lee, Sung Yong; Lee, Shin-Yup; Ryu, Jeong-Seon; Lee, Jeong Eun; Lee, Kye Young; Jang, Tae Won; Jang, Seung Hun; Yoon, Seong Hoon; Lee, Sang Hoon; Choi, Chang-min; Kim, Hyeong Ryul; Kim, Yeon Joo | Univ Eulji, Nowon Eulji Med Ctr, Dept Pulm & Crit Care Med, Seoul, South Korea; Chonnam Natl Univ, Hwasun Hosp, Dept Pulm & Crit Care Med, Gwangju, Jeonranamdo, South Korea; Catholic Univ Korea, Postech Catholic Biomed Engn Inst, Coll Med, Dept Internal Med, Seoul, South Korea; Catholic Univ, Korean Yeouido St Marys Hosp, Dept Pulm & Crit Care Med, Seoul, South Korea; Yonsei Univ, Coll Med, Yongdong Severance Hosp, Dept Internal Med, 8th Floor Annex Bldg, Seoul, South Korea; Daegu Catholic Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Korea Univ, Guro Hosp, Coll Med, Div Pulm,Dept Internal Med, Seoul, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Div Pulm & Crit Care Med, Daegu, South Korea; Inha Univ Hosp, Dept Pulm & Crit Care Med, Incheon, South Korea; Chungnam Natl Univ Hosp, Dept Internal Med, Daejeon, South Korea; Konkuk Univ, Sch Med, Dept Pulm Med, Seoul, South Korea; Kosin Univ, Med Coll, Dept Internal Med, Busan, South Korea; Hallym Univ, Sacred Heart Hosp, Dept Pulm Allergy & Crit Care Med, Anyang, South Korea; Pusan Natl Univ, Sch Med, Dept Internal Med, Yangsan, South Korea; Yonsei Univ, Inst Chest Dis, Coll Med, Div Pulmonol,Dept Internal Med, Seoul, South Korea; Univ Ulsan, Asan Med Ctr, Coll Med, Dept Pulm & Crit Care Med, Seoul, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Oncol, Seoul, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Thoracic & Cardiovasc Surg, 88 Olymp-Ro 43-Gil, Seoul 05505, South Korea | ; Lee, Sang-Hoon/ABH-6210-2020; Lee, Joo Yong/ADE-2110-2022; Park, Cheol-Kyu/AAT-9872-2021; Kim, Jung Oh/JDC-5061-2023; Lee, Jeong Eun/R-8689-2019 | 57824536400; 57205721111; 57225930594; 14623269200; 58293916800; 57223991305; 56734650000; 49863712700; 7401868634; 57209104622; 8720534800; 7102426031; 7402219050; 55479240500; 57207065392; 14024046800; 36136988200; 57311417000 | drhrkim10@gmail.com;simi20083132@gmail.com; | THORACIC CANCER | THORAC CANCER | 1759-7706 | 1759-7714 | 15 | 6 | SCIE | ONCOLOGY;RESPIRATORY SYSTEM | 2024 | 2.3 | 46.8 | 0.55 | 2025-05-07 | 1 | 1 | adverse events; anaplastic lymphoma kinase; crizotinib; non-small cell lung carcinoma; progression-free survival | PROGRESSION-FREE SURVIVAL; CHEMOTHERAPY; ALECTINIB | adverse events; anaplastic lymphoma kinase; crizotinib; non-small cell lung carcinoma; progression-free survival | Anaplastic Lymphoma Kinase; Carcinoma, Non-Small-Cell Lung; Crizotinib; Female; Humans; Lung Neoplasms; Male; Middle Aged; Protein Kinase Inhibitors; Receptor Protein-Tyrosine Kinases; anaplastic lymphoma kinase; anaplastic lymphoma kinase inhibitor; crizotinib; anaplastic lymphoma kinase; crizotinib; protein kinase inhibitor; protein tyrosine kinase; adult; age; anorexia; Article; brain metastasis; cohort analysis; drug dose reduction; drug efficacy; drug withdrawal; female; heartburn; human; Kaplan Meier method; kidney cyst; leg edema; liver toxicity; major clinical study; malaise; male; nausea; neutropenia; non small cell lung cancer; overall survival; palliative chemotherapy; pneumonia; progression free survival; rash; retrospective study; sex difference; South Korean; vomiting; clinical trial; lung tumor; middle aged; multicenter study; non small cell lung cancer; pathology | English | 2024 | 2024-02 | 10.1111/1759-7714.15213 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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