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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Increased ER stress by depletion of PDIA6 impairs primary ciliogenesis and enhances sensitivity to ferroptosis in kidney cells | Primary cilia are crucial for cellular balance, serving as sensors for external conditions. Nephronophthisis and related ciliopathies, which are hereditary and degenerative, stem from genetic mutations in cilia-related genes. However, the precise mechanisms of these conditions are still not fully understood. Our research demonstrates that downregulating PDIA6, leading to cilia removal, makes cells more sensitive to ferroptotic death caused by endoplasmic reticulum (ER) stress. The reduction of PDIA6 intensifies the ER stress response, while also impairing the regulation of primary cilia in various cell types. PDIA6 loss worsens ER stress, hastening ferroptotic death in proximal tubule epithelial cells, HK2 cells. Counteracting this ER stress can mitigate PDIA6 depletion effects, restoring both the number and length of cilia. Moreover, preventing ferroptosis corrects the disrupted primary ciliogenesis due to PDIA6 depletion in HK2 cells. Our findings emphasize the role of PDIA6 in primary ciliogenesis, and suggest its absence enhances ER stress and ferroptosis. These insights offer new therapeutic avenues for treating nephronophthisis and similar ciliopathies. | Kim, Joon Bum; Hyung, Hyejin; Bae, Ji-Eun; Jang, Soyoung; Park, Na Yeon; Jo, Doo Sin; Kim, Yong Hwan; Choi, Dong Kyu; Ryu, Hong-Yeoul; Lee, Hyun-Shik; Ryoo, Zae Young; Cho, Dong-Hyung | Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat BioRes Grp, Daegu 41566, South Korea; Kyungpook Natl Univ, KNU Inst Basic Sci, KNU LAMP Res Ctr, Daegu 41566, South Korea; ORGASIS Corp, Suwon 16229, South Korea; Kyungpook Natl Univ, Organelle Inst, Daegu 41566, South Korea | Choi, dongKyu/LKL-2959-2024; Kim, Joon/ADP-8066-2022; RYOO, ZAEYOUNG/AAQ-1573-2020; Bae, Ji-Eun/JAC-3677-2023 | 57190611030; 57247294000; 57190605352; 57139360300; 57190609826; 56335489800; 57204676401; 57215816624; 55889917800; 16316010200; 16937104900; 35093684400 | dhcho@knu.ac.kr; | BMB REPORTS | BMB REP | 1976-6696 | 1976-670X | 57 | 10 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY | 2024 | 3.3 | 45.0 | 0.78 | 2025-05-07 | 2 | 2 | ER stress; Ferroptosis; HK-2 cells; PDIA6; Primary cilia | ENDOPLASMIC-RETICULUM STRESS; APOPTOSIS; PROTEIN; DYSFUNCTION | ER stress; Ferroptosis; HK-2 cells; PDIA6; Primary cilia | Cell Line; Cilia; Endoplasmic Reticulum Stress; Epithelial Cells; Ferroptosis; Humans; Kidney; Protein Disulfide-Isomerases; PDIA6 protein, human; protein disulfide isomerase; cell line; cilium; endoplasmic reticulum stress; epithelium cell; ferroptosis; genetics; human; kidney; metabolism; pathology; physiology | English | 2024 | 2024 | 10.5483/bmbrep.2023-0247 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Revised Hyrcanus group phylogeny based on ITS2 resolution | This study presents a meticulous reassessment of the phylogenetic relationships within the Hyrcanus Group of Anopheles (Anopheles) mosquitoes, a group of substantial medical and epidemiological importance. These vectors are responsible for the transmission of various diseases, including malaria, posing a significant public health challenge in many regions. This research employs advanced molecular techniques, specifically focusing on the Internal Transcribed Spacer 2 (ITS2) region, to enhance taxonomic resolution within this complex group of mosquitoes. The ITS2 region has proven to be a valuable molecular marker for differentiating closely related species and refining our understanding of their evolutionary history. A total of 857 ITS2 sequences of Hyrcanus group members were retrieved from the GenBank after using specific search keywords. 83 out of the initial retrieved sequenced were then finally selected and utilized in the analysis based on sequence quality and length. Sequences retrieved represent 22 out of the 25 members of the Hyrcanus group. This study clarified the confusion surrounding the taxonomic placement and synonymy of each member of the Hyrcanus group using the latest available molecular ITS2 sequence data through Neighbor Joining (NJ), Maximum Likelihood (ML), and Bayesian Inference (BI) phylogenetic tree analysis. The work also revised the taxonomic groupings based on morphological characters observed within the group and evaluated the limitations within the classification based on morphology and the challenges using molecular ITS2 data. A refined understanding of the Hyrcanus group phylogeny provides a foundation for more precise and tailored approaches to combat malaria and other vector- borne diseases in South Korea. | Hwang, Ui Wook; Akintola, Ashraf Akintayo | Kyungpook Natl Univ, Dept Biomed Convergence Sci & Technol, Daegu 41566, South Korea; Kyungpook Natl Univ, Teachers Coll, Dept Biol Educ, Daegu 41566, South Korea; Kyungpook Natl Univ, Inst Phylogen & Evolut, Daegu 41566, South Korea; Kyungpook Natl Univ, Inst Korean Herb Bio Convergence Promot, Daegu 41566, South Korea; Phylomics Inc, Daegu 4910, South Korea | Akintola, Ashraf/KZU-7081-2024 | 35074015800; 57218618629 | uwhwang@knu.ac.kr; | JOURNAL OF ASIA-PACIFIC ENTOMOLOGY | J ASIA-PAC ENTOMOL | 1226-8615 | 1876-7990 | 27 | 4 | SCIE | ENTOMOLOGY | 2024 | 1.3 | 45.0 | 0 | 2025-05-07 | 0 | 0 | Mosquito; Anopheles; Hyrcanus; Species | ANOPHELES ANOPHELES; MOLECULAR-IDENTIFICATION; DIPTERA; CULICIDAE; CLASSIFICATION; MOSQUITOS; SEQUENCE; SINENSIS; CHINA; RDNA | Anopheles; Hyrcanus; Mosquito; Species | English | 2024 | 2024-12 | 10.1016/j.aspen.2024.102346 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Taxonomic review of the genus Hexacentrus Serville, 1831 (Orthoptera: Tettigoniidae) in Korea: An integrative study to confirm cryptic species | The genus Hexacentrus (Orthoptera: Tettigoniidae) comprises two species in Korea: Hexacentrus japonicus Karny, 1907, and H. hareyamai Furukawa, 1941. While H. japonicus is well-known in Korea, H. hareyamai was previously confirmed as a cryptic species through a DNA barcoding study. In this research, we reviewed the Korean Hexacentrus using morphological and bioacoustic characters and conducted a phylogenetic analysis using cytochrome oxidase I (COI) for molecular identification. We describe the cryptic species H. hareyamai in Korea, which was previously recorded as H. unicolor in a prior study. Based on our findings and the biogeographical range of Hexacentrus species, we suggest that the presence of H. unicolor in Korea should be excluded. However, since a systematic comparison of Hexacentrus species, including H. unicolor, in Southeast Asia has not been investigated in detail, further studies are needed. | Kim, Geonhyeok; Kim, Do-yoon; Kim, Taewoo; Shin, Seunggwan | Hankil Forest Inst, 103,64-3,Seonsuchon Ro, Kangnung 25522, South Korea; Kyungpook Natl Univ, Sch Ind Technol Adv, Dept Biomed Coanvergence Sci & Technol, Daegu 41566, South Korea; Seoul Natl Univ, Sch Biol Sci, Seoul 08826, South Korea; Seoul Natl Univ, Comparat Med Dis Res Ctr, Seoul 08826, South Korea; Natl Inst Biol Resources, Biodivers Educ Div, Incheon 22689, South Korea | 59117471800; 57223119810; 55696547400; 50761526600 | pulmuchi@korea.kr;sk83@snu.ac.kr; | JOURNAL OF ASIA-PACIFIC ENTOMOLOGY | J ASIA-PAC ENTOMOL | 1226-8615 | 1876-7990 | 27 | 2 | SCIE | ENTOMOLOGY | 2024 | 1.3 | 45.0 | 0 | 2025-05-07 | 1 | 0 | Orthoptera; Hexacentrus; COI; Hexacentrus hareyamai; DNA barcoding; Cryptic species | UNICOLOR SERVILLE; JAPONICUS KARNY; BUSH-CRICKET | COI; Cryptic species; DNA barcoding; Hexacentrus; Hexacentrus hareyamai; Orthoptera | English | 2024 | 2024-06 | 10.1016/j.aspen.2024.102249 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | The impact of morningness-eveningness on depression through a serial mediation model of resilience and anxiety | Objective: Resilience has been recently considered one of the possible mechanisms for the association between morningness-eveningness and depression. Meanwhile, anxiety is closely associated with mood disorder, but its association with morningness-eveningness is unclear. Therefore, this study aimed to explore the mediating effects of resilience and anxiety on morningness-eveningness and depression as the possible mechanisms.Methods: This study included patient group and nonpatient group. Patient group consists of 743 patients with mood disorders [Major Depressive Disorder (MDD), 233; Bipolar Disorder I (BDI), 113; Bipolar Disorder II (BDII), 397] whereas nonpatient group consists of 818 individuals without mood disorder. The Composite Scale of Morningness, Connor-Davidson Resilience Scale, Self-Rating Depression Scale, and Beck Anxiety Inventory were used to evaluate morningness-eveningness, resilience, anxiety, and depression, respectively.Results: Our model provided a good fit for the data. The association between morningness-eveningness and depression symptoms was partially serially mediated by resilience and anxiety in both the patient and nonpatient groups. The patient group exhibited significantly stronger morningness-eveningness toward resilience and anxiety than the nonpatient group. In the indirect effect of morningness-eveningness on depression, group differences exist only through each mediation of resilience and anxiety, not through serial mediation.Conclusion: Our results expand on the mechanism underlying the association between morningness-eveningness and depression. They highlight the importance of morningness-eveningness modification to increase resilience and the need to consider anxiety jointly in this process. | Kang, Suhyeon; Kim, Huiyeong; Yu, Hyeona; Lee, Daseul; Lee, Hyuk Joon; Ha, Tae Hyon; Park, Jungkyu; Myung, Woojae; Kang, Hyo Shin | Kyungpook Natl Univ, Dept Psychol, Daegu, South Korea; Seoul Natl Univ, Dept Neuropsychiat, Bundang Hosp, Seongnam, South Korea; Seoul Natl Univ, Dept Psychiat, Coll Med, Seoul, South Korea | ; LI, Xiaojun/AAM-7565-2020; Li, Hao yu/JDW-8159-2023; Liu, Shuxin/ADK-3792-2022; Ding, Pei-Hui/CAG-8041-2022; Ha, Tae/U-5558-2019; Myung, Woojae/AAD-3016-2021 | 58959739000; 59146713300; 57910913300; 57973764300; 59147189100; 7203014550; 56206565000; 37099034100; 57219595147 | hyoshin.kang@knu.ac.kr;jkp@knu.ac.kr;wmyung@snu.ac.kr; | ACTA NEUROPSYCHIATRICA | ACTA NEUROPSYCHIATR | 0924-2708 | 1601-5215 | 36 | 6 | SCIE | NEUROSCIENCES;PSYCHIATRY | 2024 | 2.5 | 45.0 | 0 | 2025-05-07 | 2 | 0 | Anxiety; depressive symptom; morningness-eveningness; mood disorder; resilience | CIRCADIAN TYPOLOGY; SYMPTOMS; MOOD; HOPELESSNESS; ASSOCIATIONS; CHRONOTYPE; SEVERITY; DISORDER; SLEEP; PSYCHOPATHOLOGY | Anxiety; depressive symptom; mood disorder; morningness-eveningness; resilience | adult; anxiety; Article; Beck Anxiety Inventory; bipolar I disorder; bipolar II disorder; Composite Scale of Morningness; Connor Davidson resilience scale; controlled study; cross-sectional study; depression; depression assessment; disease association; eveningness; female; human; major clinical study; major depression; male; mediation analysis; mental patient; mood disorder; morningness; Morningness-Eveningness Questionnaire; psychological resilience; Self-rating Depression Scale | English | 2024 | 2024-12 | 10.1017/neu.2024.23 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Cell-free supernatant of Lactococcus lactis IDCC 2301 exerts anti-inflammatory effects in LPS-induced macrophages via NF-xB and MAPK signaling pathways | This study investigated the anti-inflammatory effects of cell-free supernatant of Lactococcus lactis IDCC 2301 on lipopolysaccharide (LPS)-induced RAW 264.7 macrophages. Expression of inflammatory mediators and cytokines, and the production of nitric oxide (NO) and prostaglandin E 2 (PGE 2) were qualitatively analysed. The expression of signal transductors in inflammatory cascades was quantified by western blot. Treatment with cell-free supernatant of L. lactis IDCC 2301 significantly decreased the mRNA expression levels of tumour necrosis factor (TNF-alpha) and interleukins including IL1 beta and IL-6. The levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX-2) were also remarkably reduced in LPS-induced macrophages after the treatment. Furthermore, L. lactis IDCC 2301 reduced the levels of both dephosphorylated and phosphorylated forms of nuclear factor-kappa B (NF-xB), IxB-alpha, extracellular signal-regulated kinases (ERK), c-Jun amino-terminal kinases (JNK), and p38 in LPS-induced RAW 264.7 cells. Therefore, L. lactis IDCC 2301 shows anti-inflammatory activity by suppressing the NF-xB and mitogenactivated protein kinase (MAPK) signaling pathways. | Lee, M.; Chae, S. A.; Lee, Y. J.; Jeon, H. J.; Hong, S. -C.; Shin, M.; Jung, Y. H.; Yang, J. | Ildong Biosci, Pyeongtaek Si 17957, Gyeonggi Do, South Korea; Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Kunsan Natl Univ, Dept Food Sci & Biotechnol, Gunsan 54150, South Korea; Inha Univ, Coll Med, Dept Microbiol, Incheon 22212, South Korea; Dongguk Univ, Coll Med, Dept Microbiol, Gyeongju 38066, South Korea | Jeon, Hyeon Ji/HPH-4892-2023 | 59693442800; 57219223373; 58700074500; 57795638700; 58612005000; 57208401604; 55550063700; 56076383700 | younghoonjung@knu.ac.kr;dbl3jwy@dongguk.ac.kr; | BENEFICIAL MICROBES | BENEF MICROBES | 1876-2883 | 1876-2891 | 15 | 3 | SCIE | MICROBIOLOGY;NUTRITION & DIETETICS | 2024 | 3.1 | 45.1 | 0.94 | 2025-04-16 | 1 | 1 | probiotics; Lactococcus lactis; anti-inflammation; immune response; macrophages | KAPPA-B; ACTIVATION | anti-inflammation; immune response; Lactococcus lactis; macrophages; probiotics | Animals; Anti-Inflammatory Agents; Culture Media, Conditioned; Cyclooxygenase 2; Cytokines; Dinoprostone; Lactococcus lactis; Lipopolysaccharides; Macrophages; MAP Kinase Signaling System; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; RAW 264.7 Cells; Signal Transduction; Tumor Necrosis Factor-alpha; autacoid; cyclooxygenase 2; cytokine; I kappa B kinase alpha; immunoglobulin enhancer binding protein; inducible nitric oxide synthase; interleukin 1beta; interleukin 6; lipopolysaccharide; messenger RNA; mitogen activated protein kinase; mitogen activated protein kinase p38; nitric oxide; probiotic agent; prostaglandin E2; stress activated protein kinase; tumor necrosis factor; antiinflammatory agent; cyclooxygenase 2; cytokine; immunoglobulin enhancer binding protein; inducible nitric oxide synthase; lipopolysaccharide; nitric oxide; prostaglandin E2; tumor necrosis factor; animal cell; antiinflammatory activity; Article; cell free system; controlled study; Enterococcus faecium; Lactobacillus fermentum; Lactobacillus reuteri; Lactobacillus rhamnosus; Lactococcus lactis; macrophage; MAPK signaling; mouse; NF kB signaling; nonhuman; protein dephosphorylation; protein expression; protein phosphorylation; qualitative analysis; quantitative analysis; RAW 264.7 cell line; signal transduction; supernatant; Western blotting; animal; conditioned medium; drug effect; genetics; immunology; MAPK signaling; metabolism; pharmacology | English | 2024 | 2024 | 10.1163/18762891-bja00008 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Characterization of Tick-Borne Encephalitis Virus Isolates from Ixodes persulcatus Ticks Collected During 2020 in Selenge, Mongolia | Tick-borne encephalitis virus (TBEV) causes neurological disease in humans, with varied clinical severity influenced by the viral subtype. TBEV is endemic to Mongolia, where both Siberian and Far-Eastern subtypes are present. Ixodes persulcatus is considered the main vector of TBEV in Mongolia; although, the virus has also been detected in Dermacentor species. To further characterize the disease ecology of TBEV within the endemic Selenge province of Mongolia, 1300 Ixodes persulcatus ticks were collected in May 2020 from regions outside Ulaanbaatar. Pooled tick samples (n = 20-50) were homogenized and the supernatant was inoculated into Vero cells. Two RT-PCR assays were conducted on the cell supernatant following an observed cytopathic effect: one for TBEV detection and the second for viral subtyping. Lysed cell cultures were processed for next-generation sequencing (NGS) using Illumina technology. TBEV was detected in 10.7% of tick pools (3/28), and isolates were identified as the Siberian subtype. Phylogenetic analysis showed PQ479142 clustering within the Siberian subtype and sharing high similarity with published isolates collected in Selenge in 2012 from Ixodes persulcatus. Subtype analysis of circulating TBEV isolates and sequencing analytics to track viral evolution in ticks are vital to continued understanding of the risk to local populations. | Boldbaatar, Bazartseren; Cleary, Nora G.; Paoli, Julia E.; Lee, Dong-Wook; Altantogtokh, Doniddemberel; Matulis, Graham A.; Cote, Noel; Fiorenzano, Jodi; Etobayeva, Irina V.; Kwon, Jung-Hoon; Mavian, Carla; Letizia, Andrew G.; von Fricken, Michael E. | Mongolian Univ Life Sci, Sch Vet Med, Ulaanbaatar 17029, Mongolia; Univ Florida, Dept Environm & Global Hlth, Gainesville, FL 32610 USA; Univ Florida, Emerging Pathogens Inst, Gainesville, FL 32610 USA; Univ Florida, Dept Pathol Immunol & Lab Med, Gainesville, FL 32610 USA; Kyungpook Natl Univ, Coll Vet Med, Daegu 41566, South Korea; Natl Ctr Zoonot Dis, Ulaanbaatar 17029, Mongolia; INDO PACIFIC NAMRU IP, Naval Med Res Unit, Singapore 759657, Singapore; Armed Forces Pest Management Board, Silver Spring, MD 20910 USA; Smithsonian Inst, Washington, DC 20024 USA | ; mavian, carla/H-3410-2019; Bazartseren, Boldbaatar/JRW-9905-2023; von Fricken, Michael/H-3214-2019 | 26634733300; 57970175500; 59492346400; 57711484300; 57210964298; 57211560697; 58863972200; 57193908600; 57202209577; 55559800200; 26027976600; 57222123288; 55565665400 | boldbaatar.b@muls.edu.mn;ncleary@ufl.edu;paolij20@ufl.edu;ip1003@naver.com;altantogtokh@nczd.gov.mn;g.matulis@ufl.edu;noel.m.cote.mil@health.mil;jodi.m.fiorenzano@mil.mail;irina.v.etobayeva.mil@health.mil;junghoon.kwon@knu.ac.kr;cmavian@ufl.edu;andrew.g.letizia@health.mil;mvonf@ufl.edu; | PATHOGENS | PATHOGENS | 2076-0817 | 13 | 12 | SCIE | MICROBIOLOGY | 2024 | 3.3 | 45.1 | 0 | 2025-05-07 | 0 | 0 | tick-borne encephalitis virus; Siberian subtype; Ixodes persulcatus; Selenge; Mongolia; next-generation sequencing | ALIGNMENT | Ixodes persulcatus; Mongolia; next-generation sequencing; Selenge; Siberian subtype; tick-borne encephalitis virus | capsid protein; nucleocapsid protein; viral protein; viral structural protein; animal cell; Article; controlled study; cytopathogenic effect; Dermacentor; disease severity; DNA extraction; ecology; encephalitis; epidemic; evolution; fever; gene sequence; genetic distance; geographic distribution; high throughput sequencing; illumina sequencing; inoculation; Ixodes persulcatus; metagenomics; Mongolia; neurologic disease; nonhuman; phylogenetic tree; phylogeny; polymerase chain reaction; prevalence; resuscitation; sequence alignment; sequence analysis; tick; Tick borne encephalitis virus; Vero cell line; viral evolution | English | 2024 | 2024-12 | 10.3390/pathogens13121086 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | DNA Barcoding Using 18S rRNA Gene Fragments for Identification of Tick-Borne Protists in Ticks in the Republic of Korea | The objective of this study was to evaluate the diversity and prevalence of tick-borne protists in the Republic of Korea via DNA barcoding using 18S rRNA gene fragments and PCR. Between 2021 and 2022, questing ticks were collected using the flagging method, with a total of 13,375 ticks collected and pooled into 1003 samples. Of these, 50 tick pools were selected for DNA barcoding targeting the V4 and V9 regions of 18S rRNA using the MiSeq platform. A taxonomic analysis of the amplicon sequence variants identified three genera of protozoa, namely Hepatozoon canis, Theileria luwenshuni, and Gregarine sp. However, the number and abundance of protists detected were different depending on the primer sets, and T. gondii was not identified in DNA barcoding. Furthermore, conventional PCR confirmed the presence of H. canis, Toxoplasma gondii, T. luwenshuni, and Theileria sp. in the collected ticks. This study identified H. canis and T. gondii in Ixodes nipponensis for the first time. It demonstrated that the results of DNA barcoding using 18S rRNA gene fragments can vary depending on the primer sets and further optimization is required for library construction to identify tick-borne protists in ticks. Despite these limitations, the findings highlight the potential of DNA barcoding using 18S rRNA gene fragments for screening the diversity of tick-borne protists in ticks. | Alkathiri, Badriah; Lee, Subin; Ahn, Kyusung; Youn, So Youn; Yoo, Mi-Sun; Lee, Hyang-Sim; Cho, Yun Sang; Jung, Jaeyun; Seo, Kwangwon; Kim, Soochong; Umemiya-Shirafuji, Rika; Xuan, Xuenan; Kwak, Dongmi; Shin, Sungshik; Lee, Seung-Hun | Chungbuk Natl Univ, Coll Vet Med, Chungbuk 28644, South Korea; Chonnam Natl Univ, BIOREEDS Res Inst, Coll Vet Med, Gwangju 61186, South Korea; Anim & Plant Quarantine Agcy, Dept Anim & Plant Hlth Res, Bacterial Dis Div, Lab Parasit & Honeybee Dis, Gimcheon 39660, South Korea; Chungbuk Natl Univ, Coll Med, Dept Biochem, Chungbuk 28644, South Korea; Obihiro Univ Agr & Vet Med, Natl Res Ctr Protozoan Dis, Obihiro, Hokkaido 0808555, Japan; Kyungpook Natl Univ, Coll Vet Med, Daegu 41566, South Korea | ; Umemiya-Shirafuji, Rika/AFT-5139-2022; seo, kwang won/C-9392-2019; Cho, Yun Sang/ACA-6165-2022 | 57190979864; 57776738900; 36004623300; 57190743135; 57217039464; 35094118100; 16066666200; 59441396300; 57203233812; 7601600702; 24538118000; 7005428448; 7007148758; 7403646673; 57203394416 | badara25.ba@gmail.com;tnqls7488@naver.com;bonoboy1@naver.com;syyoun@korea.kr;msyoo99@korea.kr;leehs76@korea.kr;choys@korea.kr;jaeyunj@chungbuk.ac.kr;vetskw16@cbnu.ac.kr;skim0026@cbnu.ac.kr;umemiya@obihiro.ac.jp;gen@obihiro.ac.jp;dmkwak@knu.ac.kr;sungshik@jnu.ac.kr;dvmshlee@chungbuk.ac.kr; | PATHOGENS | PATHOGENS | 2076-0817 | 13 | 11 | SCIE | MICROBIOLOGY | 2024 | 3.3 | 45.1 | 0 | 2025-05-07 | 0 | 0 | next-generation sequencing; tick-borne pathogen; protozoa; tick; vector; metabarcoding | TOXOPLASMA-GONDII; MOLECULAR-DETECTION; PCR; B1 | metabarcoding; next-generation sequencing; protozoa; tick; tick-borne pathogen; vector | RNA 16S; RNA 18S; Article; bioinformatics; DNA barcoding; DNA extraction; gene insertion; Hepatozoon canis; high throughput sequencing; Korea; nymph; polymerase chain reaction; prevalence; protist; species identification; taxonomy; Theileria; tick; tick borne protist; Toxoplasma gondii | English | 2024 | 2024-11 | 10.3390/pathogens13110941 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Evaluation of RNA Secondary Stem-Loop Structures in the UTRs of Mouse Hepatitis Virus as New Therapeutic Targets | MHV-A59 is a beta-coronavirus that causes demyelinating encephalitis and hepatitis in mice. Recently, the mouse infection model of MHV-A59 has been used as an alternative animal infection model for SARS-CoV and SARS-CoV-2, aiding the development of new antiviral drugs. In this study, the MHV-A59 model was employed to investigate the potential of SARS-CoV-2 UTRs as new targets for antiviral drugs. Optimal targets within the MHV-A59 UTRs were identified using a shRNA and siRNA design tool, focusing on RNA secondary stem-loop (SL) structures in the UTRs. We then examined whether the designed RNAi constructs could inhibit MHV-A59 replication. In the 5 ' UTR, the stem-loop 1 (SL1) was identified as the most effective target, while in the 3 ' UTR, the minimal element for the initiation of negative-strand RNA synthesis (MIN) proved to be the most effective. Importantly, siRNAs targeting SL1 and MIN structures significantly reduced total RNA synthesis, negative-strand genomic RNA synthesis, subgenomic (sg) RNA synthesis, viral titer, and the plaque size of MHV-A59 compared to the control. Although not statistically significant, the combination of siSL1 and siMIN had a stronger effect on inhibiting MHV-A59 replication than either siRNA monotherapy. Interestingly, while the SL1 structure is present in both MHV and SARS-CoV-2, the MIN structure is unique to MHV. Thus, the SL1 of SARS-CoV-2 may represent a novel and promising target for RNAi-based antiviral drugs. | Kang, Gyuhyun; Lee, Sun Hee; Cho, Miyeon; Kim, Ji-hyeon; Cho, Hyosun; Kang, Hyojeung | Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, Vessel Organ Interact Res Ctr, Daegu 41566, South Korea; Duksung Womens Univ, Coll Pharm, Duksung Innovat Drug Ctr, Seoul 01369, South Korea | 59188773700; 58607352900; 57190213901; 59189008300; 55572361200; 8979751700 | gyuhyun14@gmail.com;ihappy278@nate.com;cmy1004g@naver.com;58dekl@naver.com;hyosun1102@duksung.ac.kr;hkang72@knu.ac.kr; | PATHOGENS | PATHOGENS | 2076-0817 | 13 | 6 | SCIE | MICROBIOLOGY | 2024 | 3.3 | 45.1 | 0 | 2025-05-07 | 0 | 0 | MHV-A59; UTR; stem-loop; shRNA; siRNA | MURINE CORONAVIRUS; 5'-UNTRANSLATED REGION; REPLICATION; CEACAM1; ELEMENT | MHV-A59; shRNA; siRNA; stem-loop; UTR | messenger RNA; oligonucleotide; puromycin; short hairpin RNA; small interfering RNA; small untranslated RNA; subgenomic mRNA; untranslated RNA; 3' untranslated region; analysis of variance; animal cell; animal experiment; animal model; Article; base pairing; Betacoronavirus; chemoluminescence; controlled study; cytopathogenic effect; cytotoxicity; drug analysis; encephalitis; gene expression; gene silencing; genetic analysis; hepatitis; hepatitis virus; immunoblotting; Lentivirus; monotherapy; mouse; Murine hepatitis virus; nonhuman; Northern blotting; pharmacology; phylogeny; polymerase chain reaction; real time polymerase chain reaction; RNA extraction; RNA interference; RNA Secondary Stem Loop Structure; RNA structure; RNA synthesis; RNAi therapeutics; SARS coronavirus; sequence analysis; Severe acute respiratory syndrome coronavirus 2; statistical analysis; untranslated region; virus load; virus replication; virus transmission | English | 2024 | 2024-06 | 10.3390/pathogens13060518 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Effects of inorganic nanoparticle incorporation on the performance of planar hybrid organic solar cells: analysis of electrical and morphological properties | In this study, we fabricated planar hybrid organic solar cells (PHOSCs) with ITO/PEDOT:PSS/(PCBM:PTB7)/E-GaIn nanostructure using vacuum-free deposition. The active layer consisted of PCBM and PTB7 as n-type and p-type materials, respectively. PEDOT:PSS was used as hole-transporting material, whereas ITO and E-GaIn served as anode and cathode, respectively. The incorporation of an inorganic material as third component improved the performance of the device, leading to high conductivity and sunlight absorption, as well as good solution processability. Spherical nanoparticles (SNPs) consisting of inorganic cadmium selenide (CdSe) and zinc oxide (ZnO) were synthesized and characterized. The optical and morphological properties of the CdSe and ZnO nanoparticles were determined using TEM, HR-TEM, UV-vis, AFM, VCA, and SEM techniques. The optimized device showed the highest power conversion efficiency (PCE) of 8.2%, with a short-circuit density (Jsc) of 15.2 mA/cm2, an open-circuit voltage (Voc) of 770 mV, and a fill factor (FF) of 70%. | Truong, Nguyen Tam Nguyen; Lam, Nguyen Hoang; Kim, Chang-Duk; Kang, Seung Beom; Jung, Jinjoo; Pawar, Bharat G.; Al-Enizi, Abdullah M.; Jo, Younjung; Tamboli, Mohaseen S.; Jung, Jae-Hak | Yeungnam Univ, Sch Chem Engn, 280 Daehak Ro, Gyeongbuk 38541, Gyeongsan, South Korea; Tra Vinh Univ, Inst Environm Sci & Technol, Tra Vinh 940000, Vietnam; Kyungpook Natl Univ, Dept Phys, 80 Daehakro, Bukgu 41566, Daegu, South Korea; Korea Carbon Ind Promot Agcy, Res & Dev Ctr, 110-11 Banryong Ro, Jeonju 54853, South Korea; Sangola Coll, Dept Chem, Sangola 413307, Maharashtra, India; King Saud Univ, Coll Sci, Dept Chem, POB 2455, Riyadh 11451, Saudi Arabia; Korea Inst Energy Technol KENTECH, 21 KENTECH Gil, Naju 58330, Jeollanam Do, South Korea | Al-Enizi, Abdullah/C-8365-2016; Lam, Nguyen/KRO-9111-2024 | 25958384000; 58313026700; 57200982445; 58032913000; 55750032400; 57219351920; 57204659532; 13502586500; 6506784566; 13308234300 | jophy@knu.ac.kr;tamboli.mohseen@gmail.com;jhjung@ynu.ac.kr; | JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS | J MATER SCI-MATER EL | 0957-4522 | 1573-482X | 35 | 31 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC;MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED;PHYSICS, CONDENSED MATTER | 2024 | 2.8 | 45.2 | 0 | 2025-05-07 | 0 | 0 | LOW-BAND-GAP; BUFFER LAYER; EFFICIENT; POLYMERS; ZNO | Cadmium telluride; Conducting polymers; Hard facing; Layered semiconductors; Nanoclay; Open circuit voltage; Organic solar cells; Selenium compounds; Vacuum deposition; Zinc Selenide; Active Layer; Cadmium selenides; Cell analysis; Inorganic nanoparticle; Morphological properties; Organics; P-type; PEDOT/PSS; Performance; Vacuum-free; ZnO nanoparticles | English | 2024 | 2024-11 | 10.1007/s10854-024-13788-7 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Effects of synthesis time on the optical-electrical and structural properties of silicon carbide/graphite core-shell structures for supercapacitor applications | Silicon carbide-graphite core-shells (SiC-GRCSs) structure were synthesized using the thermal chemical vapor deposition method. The systhesis time was varried, ranging from 1 to 4 min. The morphological, structural, compositional, and electrical properties of the SiC-GRCS structure at different of synthesis time were analyzed and investigated. The optimized SiC-GRCS structure were then applied as electrodes in pseudosupercapacitor applications. Electrochemical measurements were conducted using the cyclic voltammetry and galvanostatic charge-discharge (GCD) techniques. The SiC-GRCS structure exhibited a high specific capacitance of approximately 3415 F/g at a current density of 0.25 A/g. | Lam, Nguyen Hoang; Kim, Chang-Duk; Kang, Seung Beom; Lee, Kyeong Seok; Chung, Dong Chul; Jo, Younjung; Hieu, Nguyen Huu; Shaikh, Hamid; Al-Zahrani, Saeed M.; Truong, Nguyen Tam Nguyen | Tra Vinh Univ, Tra Vinh 940000, Vietnam; Kyungpook Natl Univ, Dept Phys, 80 Daehakro, Bukgu 41566, Daegu, South Korea; Korea Carbon Ind Promot Agcy, Res & Dev Ctr, 110-11 Banryong Ro, Jeonju 54853, South Korea; Jeonbuk Natl Univ, Carbon Fiber Convergence Technol Res Ctr, 567 Baekje Daero, Jeonju SI 54896, Jeonrabugdo, South Korea; Ho Chi Minh City Univ Technol HCMUT, VNU HCM, Fac Chem Engn, Key Lab Chem Engn & Petr Proc Key CEPP Lab, Ho Chi Minh City, Vietnam; King Saud Univ, SABIC Polymer Res Ctr, Chem Engn Dept, POB 800, Riyadh 11421, Saudi Arabia; Yeungnam Univ, Sch Chem Engn, 280 Daehak Ro, Gyeongbuk 38541, Gyeongsan, South Korea | Hamidi, Sami/KIH-8546-2024; Lam, Nguyen/KRO-9111-2024; Alzahrani, Saeed/LMO-8000-2024 | 58313026700; 57200982445; 58032913000; 57435481000; 7401719367; 13502586500; 57023533100; 55919054400; 7005105930; 25958384000 | jjjung@knu.ac.kr;tamnguyentn@ynu.ac.kr; | JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS | J MATER SCI-MATER EL | 0957-4522 | 1573-482X | 35 | 16 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC;MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED;PHYSICS, CONDENSED MATTER | 2024 | 2.8 | 45.2 | 0 | 2025-05-07 | 0 | 0 | PEROVSKITE SOLAR-CELLS; GRAPHENE; CARBIDE; CARBON; NANOCOMPOSITES; ELECTRODES; NANOPARTICLES; PERFORMANCE; EFFICIENCY; REMOVAL | Chemical vapor deposition; Cyclic voltammetry; Electric discharges; Supercapacitor; Core shell structure; Electrical and structural properties; Electrochemical measurements; Graphite core; Optical-; Supercapacitor application; Synthesis time; Synthesised; Systhesis; Thermal chemical vapor deposition method; Silicon carbide | English | 2024 | 2024-06 | 10.1007/s10854-024-12767-2 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Impact of different europium concentrations on the photo and radioluminescence properties of silicofluorophosphate glass for reddish-orange emitting and scintillating materials | Silicofluorophosphate (PSEu) glasses doped with various amounts of Eu2O3 were fabricated by the melt quenching technique to know their potential use in reddish-orange lighting, especially in scintillator properties. Refractive indices, densities, and molar volumes of the PSEu glasses were obtained. Functional groups of the prepared glasses were studied in the range of 500 to 4000 cm-1 using infrared spectroscopy. The absorption of PSEu glasses was studied in the range of 350-2400 nm range and contained peaks from the 7F1 and 7F0 ground levels. The excitation band at the 7F0 -> 5D2 (463 nm) transition is of interest in the present work to estimate the phonon energy value (1222 cm-1) of the host glass using the PSB (phonon side band) spectroscopy. JO theory was applied to determine the Omega 2, 4, 6 intensity parameters by fitting the calculated and experimental oscillator strengths of the various absorption bands of Eu3+ ions. The asymmetric ratio between 5D0 -> 7F1 and 5D0 -> 7F2 emission transitions was calculated due to the dependences of Eu3+ ions on local symmetry at the 5D0 -> 7F2 emission transition. The decay curves for the 5D0 (614 nm) state of Eu3+ were measured upon 394 nm stimulation, which exhibits the single exponential nature in PSEu glasses. The color coordinates (x, y) of PSEu glasses were located near the reddish-orange zone. The radioluminescence characteristics of PSEu glasses and BGO crystal were studied under x-ray excitation in terms of scintillation efficiency. | Meejitpaisan, P.; Doddoji, Ramachari; Kothan, S.; Kim, H. J.; Kaewkhao, J. | Nakhon Pathom Rajabhat Univ, Fac Sci & Technol, Phys Program, Nakhon Pathom 73000, Thailand; Nakhon Pathom Rajabhat Univ, Ctr Excellence Glass Technol & Mat Sci CEGM, Nakhon Pathom 73000, Thailand; Duy Tan Univ, Inst Res & Dev, Da Nang 550000, Vietnam; Duy Tan Univ, Fac Nat Sci, Da Nang 550000, Vietnam; Chiang Mai Univ, Fac Associated Med Sci, Ctr Radiat Res & Med Imaging, Dept Radiol Technol, Chiang Mai 50200, Thailand; Kyungpook Natl Univ, Dept Phys, Daegu 41566, South Korea | ; Meejitpaisan, Piyachat/HSG-3266-2023; Ramachari, D./C-1205-2019 | 56006076500; 57214510277; 6507017165; 58483690400; 23974520300 | doddojiramachari@duytan.edu.vn;jakrapong@webmail.npru.ac.th; | JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS | J MATER SCI-MATER EL | 0957-4522 | 1573-482X | 35 | 34 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC;MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED;PHYSICS, CONDENSED MATTER | 2024 | 2.8 | 45.2 | 0 | 2025-05-07 | 0 | 0 | GADOLINIUM CALCIUM-PHOSPHATE; OPTICAL-PROPERTIES; EU3+ IONS; SPECTROSCOPIC PROPERTIES; LASER; FLUORESCENCE | Atomic emission spectroscopy; Scintillation counters; Density and molar volumes; Emission transition; Excitation bands; Functionals; Ground level; Infrared: spectroscopy; Melt quenching techniques; Property; Radio-luminescence; Scintillator properties; Scintillation | English | 2024 | 2024-12 | 10.1007/s10854-024-13875-9 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Composting textile sludge using plant growth-promoting rhizobacteria in a solid-state bioreactor: a step towards zero discharge | The generation of solid dye waste during wastewater purification, especially in coagulation/precipitation steps, and its detoxification, is a major issue because it can leach into the ground water from the landfills during rains. The semisolid textile waste (sludge) showed 99 and 97% decolourization at flask and reactor scale within 72 h, respectively, when treated with consortium containing Azotobacter vinelandii MTCC 1241, Rhodobacter erythropholis MTCC 4688, Bacillus megaterium NCIM 2054 and Rhizobium meliloti NCIM 2757. The decolourization rate of textile sludge majorly affected by the pH, temperature and moisture content of the sludge. At the optimum conditions of pH (6), temperature (30 degrees C) and moisture content (90%), the consortium showed maximum decolourization of 81, 84 and 97%, respectively. A significant increase in the activities of oxidoreductase enzymes such as lignin peroxidase (5 fold), laccase (2.6 fold), veratryl alcohol oxidase (4.7 fold) and tyrosinase (2.9 fold) was observed, while azo reductase (- 1.3 fold) showed a decrease in the activity during sludge treatment. In addition, a noteworthy reduction in the concentration of macromolecules N (45%), P (70%), K (50%) and C (63%), and microelements B (59%), Cu (50%), Fe (59%) and Mn (75%) were also observed after treatment with sludge bed reactor. Bio-transformed sludge showed less toxic effects on plants. The outcome from the sludge bed bioreactor (solid-state bioreactor) was found to be more effective and can be used using sugar industry waste like sugarcane bagasse for composting. | Kadam, S. K.; Chandanshive, V. V.; Watharkar, A. D.; Vyavahare, G. D.; Kadam, A. A.; Perveen, K.; Choo, Y-S.; Govindwar, S. P.; Pak, J. H. | Kyungpook Natl Univ, Res Inst Dok Do & Ulleung Do Isl, Daegu 41566, South Korea; Shivaji Univ, Dept Biochem, Kolhapur 416004, Maharashtra, India; Changu Kana Thakur Coll Art Commerce & Sci, Dept Biotechnol, Mumbai 410206, India; Chungbuk Natl Univ, Dept Environm & Biol Chem, Cheongju 28644, Chungbuk, South Korea; Dongguk Univ Seoul, Res Inst Biotechnol & Med Converged Sci, Biomed Campus,32 Dongguk Ro, Goyang Si 10326, Gyeonggi Do, South Korea; King Saud Univ, Coll Sci, Dept Bot & Microbiol, POB 22452, Riyadh 11495, Saudi Arabia | Perveen, Prof. Kahkashan/N-1679-2014; Vyavahare, Govind/GYA-4459-2022; Perveen, Kahkashan/N-1679-2014; Kadam, Dr Suhas/HNI-6437-2023; Kadam, Dr. Suhas/HNI-6437-2023 | 57188723669; 56340221300; 55191320600; 57198436376; 56267499300; 36135936700; 26040458100; 6603868071; 7102232932 | suhas397@gmail.com;jhpak@knu.ac.kr; | INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY | INT J ENVIRON SCI TE | 1735-1472 | 1735-2630 | 21 | 3 | SCIE | ENVIRONMENTAL SCIENCES | 2024 | 3.4 | 45.3 | 0.41 | 2025-05-07 | 1 | 1 | Compost; Decolorization; Sludge; Textile effluent; Toxicity | WASTE-WATER; SUGARCANE BAGASSE; DYES; PRETREATMENT; DEGRADATION; REMEDIATION; EFFLUENT | Compost; Decolorization; Sludge; Textile effluent; Toxicity | Bacteriology; Composting; Effluents; Enzymes; Fermentation; Moisture; Bacteriology; Bioconversion; Composting; Detoxification; Effluents; Enzymes; Fermentation; Groundwater; Moisture; Moisture determination; Textile industry; Textiles; Bacillus megaterium; Compost; Decolorization rates; Decolourization; Plant growth-promoting rhizobacteria; Sludge; Textile effluent; Waste sludge; Wastewater purification; Zero discharge; alcohol; bioreactor; compost; dye; lignin; moisture content; sludge; toxicity; wastewater treatment; Bioreactors | English | 2024 | 2024-02 | 10.1007/s13762-023-05193-0 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Erratum | Correction to: Composting textile sludge using plant growth-promoting rhizobacteria in a solid-state bioreactor: a step towards zero discharge (International Journal of Environmental Science and Technology, (2024), 21, 3, (3329-3336), 10.1007/s13762-023-05193-0) | In this article, the title was incorrectly given as 'posting textile sludge using plant growth promoting rhizobacteria in a solid-state bioreactor: a step towards zero discharge' but should have been 'Composting textile sludge using plant growth promoting rhizobacteria in a solid-state bioreactor: a step towards zero discharge'. The original article has been corrected. © The Author(s) under exclusive licence to Iranian Society of Environmentalists (IRSEN) and Science and Research Branch, Islamic Azad University 2023. | Kadam, S.K.; Chandanshive, V.V.; Watharkar, A.D.; Vyavahare, G.D.; Kadam, A.A.; Perveen, K.; Choo, Y.-S.; Govindwar, S.P.; Pak, J.H. | Research Institute for Dok-do and Ulleung-do Island, Kyungpook National University, Daegu, 41566, South Korea; Department of Biochemistry, Shivaji University, Kolhapur, 416004, India; Department of Biotechnology, Changu Kana Thakur Art, Commerce and Science College, New Panvel (Autonomous), 410206, India; Department of Environmental and Biological Chemistry, Chungbuk National University, Chungbuk, Cheongju, 28644, South Korea; Research Institute of Biotechnology and Medical Converged Science, Dongguk University-Seoul, Biomedi Campus, 32 Dongguk-ro, Ilsandong-gu, Gyeonggi-do, Goyang-si, 10326, South Korea; Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box-22452, Riyadh, 11495, Saudi Arabia; Research Institute for Dok-do and Ulleung-do Island, Kyungpook National University, Daegu, 41566, South Korea; Department of Biochemistry, Shivaji University, Kolhapur, 416004, India; Research Institute for Dok-do and Ulleung-do Island, Kyungpook National University, Daegu, 41566, South Korea | 57188723669; 56340221300; 55191320600; 57198436376; 56267499300; 36135936700; 26040458100; 6603868071; 7102232932 | suhas397@gmail.com;jhpak@knu.ac.kr; | International Journal of Environmental Science and Technology | INT J ENVIRON SCI TE | 1735-1472 | 1735-2630 | 21 | 5 | SCIE | ENVIRONMENTAL SCIENCES | 2024 | 3.4 | 45.3 | 0 | 2025-05-07 | 0 | English | Final | 2024 | 10.1007/s13762-023-05247-3 | 바로가기 | 바로가기 | 바로가기 | |||||||||
| ○ | ○ | Article | Exploring the Correlation between Systemic Inflammatory Markers and Carotid Atherosclerosis Indices in Middle-Aged Adults: A Cross-Sectional Study | Background: This study investigated the association between atherosclerosis and systemic inflammation markers, specifically the C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR), in healthy middle-aged adults. Methods: A retrospective cross-sectional study was conducted on a total of 1264 Korean adults aged 40-65. We assessed these inflammatory markers and carotid metrics, such as carotid intima-media thickness (cIMT), plaque number (PN), plaque stenosis score (PSS), and plaque score (PS), using linear regression, logistic regression, and receiver operating characteristic analysis. Results: In males, the ESR and CRP were significantly correlated with the PN (p < 0.001 and p = 0.048, respectively). The ESR was correlated with the PN in females (p = 0.004). The NLR and PLR both correlated with the PS in males (p < 0.001 and p = 0.015, respectively) and females (p = 0.015 and p = 0.023, respectively). The odds ratio for the NLR as a risk factor for increased cIMT was 1.15 (95% confidence interval [CI], 1.03-2.15) for males and 1.05 (95% CI, 1.01-1.29) for females. The AUC for the NLR and PLR as a predictor for the PS showed significance in both men and women. Conclusions: Inflammatory markers, particularly the NLR and PLR, demonstrate a correlation with carotid atherosclerosis. Both the NLR and PLR hold potential as valuable surrogate markers for carotid atherosclerosis. To further substantiate their predictive efficacy, further prospective studies are needed. | Song, Ji-Eun; Hwang, Ji-In; Ko, Hae-Jin; Park, Ji-Yeon; Hong, Hee-Eun; Kim, A-Sol | Kyungpook Natl Univ, Dept Family Med, Chilgok Hosp, Daegu 41404, South Korea; Kyungpook Natl Univ Hosp, Dept Family Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Family Med, Daegu 41944, South Korea | ; Song, Jieun/LLM-7026-2024 | 57217295366; 58965852600; 54393415700; 57226386288; 57218525734; 57203290656 | love2uje@naver.com;hwangjiin23@naver.com;liveforme@knu.ac.kr;miniev@naver.com;hhe8824@naver.com;deepai@knu.ac.kr; | JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE | J CARDIOVASC DEV DIS | 2308-3425 | 11 | 3 | SCIE | CARDIAC & CARDIOVASCULAR SYSTEMS | 2024 | 2.3 | 45.4 | 5.64 | 2025-05-07 | 7 | 7 | carotid stenosis; carotid plaque; inflammatory marker; neutrophil-lymphocyte ratio; platelet-lymphocyte ratio | INTIMA-MEDIA THICKNESS; TO-LYMPHOCYTE RATIO; ARTERY STENOSIS; CARDIOVASCULAR-DISEASES; RISK-FACTORS; NEUTROPHIL; PLATELET; BURDEN; STROKE; ASSOCIATION | carotid plaque; carotid stenosis; inflammatory marker; neutrophil–lymphocyte ratio; platelet–lymphocyte ratio | C reactive protein; adult; aged; Article; cardiovascular risk factor; carotid atherosclerosis; carotid intima-media thickness; cohort analysis; controlled study; cross-sectional study; echography; erythrocyte sedimentation rate; female; human; inflammation; Korean (people); linear regression analysis; logistic regression analysis; major clinical study; male; middle aged; neutrophil lymphocyte ratio; platelet lymphocyte ratio; protein blood level; retrospective study | English | 2024 | 2024-03 | 10.3390/jcdd11030073 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Hydroxychloroquine in obstetrics: potential implications of the prophylactic use of hydroxychloroquine for placental insufficiency during pregnancy | Proper placentation during early pregnancy is a key factor for maintaining a healthy pregnancy. Placental insufficiency leads to critical complications such as preeclampsia, fetal growth restriction, and fetal demise. These complications are often associated with pathological findings of restricted remodeling and obstructive lesions of the myometrial spiral arteries, which have high recurrence rates during subsequent pregnancies. Currently, there are no pharmacological interventions other than aspirin for the prevention of preeclampsia. Hydroxychloroquine (HCQ), a well-known antimalarial drug, reduces inflammatory and thrombotic changes in vessels. For decades, the use of HCQ for autoimmune diseases has resulted in the successful prevention of both arterial and venous thrombotic events and has been extended to the treatment of lupus and antiphospholipid antibody syndrome during pregnancy. HCQ reduces the risk of preeclampsia with lupus by up to 90%. Several recent studies have investigated whether HCQ improves pregnancy outcomes in women with a history of poor outcomes. In addition, in vitro and animal studies have demonstrated the beneficial effects of HCQ in improving endothelial dysfunction and alleviating hypertension and proteinuria. Therefore, we hypothesized that HCQ has the potential to attenuate the vascular inflammatory and thrombogenic pathways associated with placental insufficiency and conducted a multicenter clinical trial on the efficacy of combining aspirin with HCQ for pregnancies at high risk for preeclampsia in Korea. This study summarizes the potential effects of HCQ on pregnancies with placental insufficiency and the implications of HCQ treatment in the field of obstetrics. | Kim, Yoo-Min; Sung, Ji-Hee; Cha, Hyun-Hwa; Oh, Soo-Young | Chung Ang Univ, Gwangmyeong Hosp, Sch Med, Dept Obstet & Gynecol, Daegu, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Obstet & Gynecol, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Obstet & Gynecol, Daegu, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Obstet & Gynecol, 81 Irwon Ro, Seoul 06351, South Korea | Kim, Yoo-min/AAZ-6413-2020 | 57191974142; 56347330000; 37033517800; 55601514300 | ohsymd@skku.edu; | OBSTETRICS & GYNECOLOGY SCIENCE | OBSTET GYNECOL SCI | 2287-8572 | 2287-8580 | 67 | 2 | ESCI | OBSTETRICS & GYNECOLOGY | 2024 | 1.9 | 45.4 | 1.03 | 2025-04-16 | 3 | 1 | Hydroxychloroquine; Placenta disease; Preeclampsia; Fetal growth restriction; Fetal death | SYSTEMIC-LUPUS-ERYTHEMATOSUS; INTRAUTERINE GROWTH RESTRICTION; HYPERTENSIVE DISORDERS; PREECLAMPSIA; PREVENTION; MANAGEMENT; CHLOROQUINE; GUIDELINES; ASPIRIN; WOMEN | Fetal death; Fetal growth restriction; Hydroxychloroquine; Placenta disease; Preeclampsia | English | 2024 | 2024-03 | 10.5468/ogs.23252 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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