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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Evaluating the Nutritional Composition of Unripe Citrus and Its Effect on Inhibiting Adipogenesis and Adipocyte Differentiation | Citrus fruits offer a range of health benefits due to their rich nutritional profile, including vitamin C, flavonoids, carotenoids, and fiber. It is known that unripe citrus has higher levels of vitamin C, dietary fiber, polyphenols, and flavonoids compared to mature fruits. In this study, we assessed the nutritional components of unripe citrus peel and pressed juices, as well as their anti-obesity potential through the modulation of adipocyte differentiation and the expression of adipogenesisrelated genes, specifically PPAR gamma and C/EBP alpha, in 3T3-L1 preadipocytes. Our analysis revealed that unripe citrus peel exhibited elevated levels of fiber and protein compared to pressed juice, with markedly low levels of free sugar, particularly sucrose. The content of hesperidin, a representative flavonoid in citrus fruits, was 3,157.6 mg/kg in unripe citrus peel and 455.5 mg/kg in pressed juice, indicating that it was approximately seven times higher in unripe citrus peel compared to pressed juice. Moreover, we observed that the peel had a dose-dependently inhibitory effect on adipocyte differentiation, which was linked to a significant downregulation of adipogenesis-related gene expression. Thus, our findings suggest that unripe citrus possesses anti-obesity effects by impeding adipogenesis and adipocyte differentiation, with the peel demonstrating a more pronounced effect compared to pressed juice. | Kim, Sunghee; Lee, Eunbi; Park, Juhye; Nam, Ju-Ock; Kim, Soo Rin | Kyungpook Natl Univ, Res Inst Tailored Food Technol, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea | Kim, Soo Rin/X-2192-2019 | 59199868800; 57798039800; 58508479500; 7201496105; 36659584200 | namjo@knu.ac.kr;soorinkim@knu.ac.kr; | JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | J MICROBIOL BIOTECHN | 1017-7825 | 1738-8872 | 34 | 6 | SCIE | MICROBIOLOGY;BIOTECHNOLOGY & APPLIED MICROBIOLOGY | 2024 | 3.1 | 44.4 | 0 | 2025-05-07 | 0 | 0 | Unripe citrus; nutritional composition; hesperidin; adipogenesis; anti-obesity | METABOLIC SYNDROME; PPAR-GAMMA; OBESITY; PEEL | adipogenesis; anti-obesity; hesperidin; nutritional composition; Unripe citrus | 3T3-L1 Cells; Adipocytes; Adipogenesis; Animals; Anti-Obesity Agents; Ascorbic Acid; CCAAT-Enhancer-Binding Protein-alpha; Cell Differentiation; Citrus; Dietary Fiber; Flavonoids; Fruit; Fruit and Vegetable Juices; Hesperidin; Mice; Plant Extracts; PPAR gamma; CCAAT enhancer binding protein alpha; citrus fruit extract; flavonoid; fructose; glucose; hesperetin; hesperetin 7 o glucoside; hesperidin; peroxisome proliferator activated receptor gamma; sucrose; unclassified drug; antiobesity agent; ascorbic acid; CCAAT enhancer binding protein alpha; flavonoid; hesperidin; peroxisome proliferator activated receptor gamma; plant extract; 3T3-L1 cell line; adipocyte; adipogenesis; Article; CEBPa gene; cell differentiation; citrus fruit; citrus juice; controlled study; diet composition; dietary fiber; down regulation; drug effect; fat content; fruit peel; gene expression; moisture; pH; physical chemistry; PPARg gene; proadipocyte; protein content; protein intake; 3T3-L1 cell line; animal; chemistry; Citrus; cytology; fruit; fruit and vegetable juice; genetics; metabolism; mouse | English | 2024 | 2024-06 | 10.4014/jmb.2403.03015 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Innate Immune-Enhancing Effect of Pinus densiflora Pollen Extract via NF-κB Pathway Activation | Considering the emergence of various infectious diseases, including the coronavirus disease 2019 (COVID-19), people's attention has shifted towards immune health. Consequently, immuneenhancing functional foods have been increasingly consumed. Hence, developing new immuneenhancing functional food products is needed. Pinus densiflora pollen can be collected from the male red pine tree, which is commonly found in Korea. P. densiflora pollen extract (PDE), obtained by water extraction, contained polyphenols (216.29 +/- 0.22 mg GAE/100 g) and flavonoids (35.14 +/- 0.04 mg CE/100 g). PDE significantly increased the production of nitric oxide (NO) and reactive oxygen species (ROS) but, did not exhibit cytotoxicity in RAW 264.7 cells. Western blot results indicated that PDE induced the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2. PDE also significantly increased the mRNA and protein levels of cytokines and the phosphorylation of IKK alpha/beta and p65, as well as the activation and degradation of I kappa B alpha. Additionally, western blot analysis of cytosolic and nuclear fractions and immunofluorescence assay confirmed that the translocation of p65 to the nucleus after PDE treatment. These results confirmed that PDE increases the production of cytokines, NO, and ROS by activating NF-kappa B. Therefore, PDE is a promising nutraceutical candidate for immune-enhancing functional foods. | Jang, Sehyeon; Kim, San; Kim, Se Jeong; Kim, Jun Young; Gu, Da Hye; So, Bo Ram; Ryu, Jung A.; Park, Jeong Min; Yoon, Sung Ran; Jung, Sung Keun | Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Gyeongsangbuk Do Agr Res & Extens Serv, Div Agr Environm Res, Daegu 41404, South Korea; COSMAX NBT INC, Seongnam 13486, South Korea; Kyungpook Natl Univ, Res Inst Tailored Food Technol, Daegu 41566, South Korea | Jung, SUNG KEUN/AGR-2623-2022 | 58142092600; 58142092500; 58141666300; 59865780200; 58909933900; 57218122440; 57216744726; 58102062900; 24400410500; 35310491400 | sryoon@korea.kr;skjung04@knu.ac.kr; | JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | J MICROBIOL BIOTECHN | 1017-7825 | 1738-8872 | 34 | 3 | SCIE | MICROBIOLOGY;BIOTECHNOLOGY & APPLIED MICROBIOLOGY | 2024 | 3.1 | 44.4 | 1.03 | 2025-04-16 | 1 | 2 | Cytokines; health functional food; immune enhancement; innate immunity; nuclear factor- kappa B; Pinus densiflora pollen | RAW264.7 MACROPHAGES; NITRIC-OXIDE; EXPRESSION; CYTOKINES; CELLS; ROS | Cytokines; health functional food; immune enhancement; innate immunity; nuclear factor-kappa B; Pinus densiflora pollen | Cyclooxygenase 2; Cytokines; Humans; Immunity, Innate; Lipopolysaccharides; Macrophages; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Pinus; Reactive Oxygen Species; cytokine; flavonoid; immunoglobulin enhancer binding protein; interleukin 1beta; interleukin 6; messenger RNA; nitric oxide; nitric oxide synthase; pollen extract; polyphenol; reactive oxygen metabolite; tumor necrosis factor; cyclooxygenase 2; immunoglobulin enhancer binding protein; inducible nitric oxide synthase; lipopolysaccharide; Article; cytotoxicity; extraction; functional food; human; human cell; immunity; immunofluorescence assay; innate immunity; Korea; phosphorylation; pine; Pinus densiflora; RAW 264.7 cell line; signal transduction; Western blotting; genetics; innate immunity; macrophage; metabolism | English | 2024 | 2024-03 | 10.4014/jmb.2309.09026 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | L-Serine Protects Murine Retinal Ganglion Cells from Oxidative Stress via Modulation of Mitochondrial Dysfunction | Purpose: This study aimed to investigate the effects of L-serine on mitochondrial dysfunction in retinal ganglion cells after exposure to H2O2-induced oxidative stress. Methods: Retinal ganglion cells obtained from C57BL6 mice (postnatal days 1-4) were purified and cultured. A cell viability assay was performed following exposure to H2O2-induced oxidative stress to assess the cytoprotective effects of L-serine on retinal ganglion cells. Flow cytometry with CellROX Deep Red and MitoSOX dyes was performed to analyze the cytoplasmic and mitochondrial reactive oxygen species levels, respectively. Staining with the fluorescent probe JC-1 was used to detect changes in the mitochondrial membrane potential. The oxygen consumption rate and Bioenergetic Health Index were used to evaluate mitochondrial respiration. Results: H2O2 treatment was found to induce mitochondrial dysfunction in retinal ganglion cells. Pretreatment with L-serine prevented cytotoxicity and significantly increased the viability of retinal ganglion cells following exposure to H2O2-induced oxidative stress (p < .05). L-Serine alleviated reactive oxygen species production in retinal ganglion cells following exposure to H2O2-induced oxidative (p < .05). Further, it successfully mitigated H2O2-induced mitochondrial depolarization in retinal ganglion cells (p < .05) and significantly increased the oxygen consumption rate and Bioenergetic Health Index in retinal ganglion cells following exposure to H2O2-induced oxidative stress (p < .05). Conclusion: Pretreatment with L-serine protected retinal ganglion cells from H2O2-induced oxidative stress by improving mitochondrial function. The findings of the present study suggest that L-serine is a potential candidate for treatment of reactive oxygen species-related ocular diseases such as mitochondrial optic neuropathies. | Kwak, Soyoung; Hwang, Su-Kyeong; Kwon, Mi Sun; Chun, Bo Young | Kyungpook Natl Univ, Astrogen Inc, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Ophthalmol, Daegu, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Sch Med, Dept Ophthalmol, 680 Gukchaebosang St, Daegu 700422, South Korea | 58776377700; 37761570400; 58734575300; 25644902100 | byjun424@hotmail.com; | CURRENT EYE RESEARCH | CURR EYE RES | 0271-3683 | 1460-2202 | 49 | 10 | SCIE | OPHTHALMOLOGY | 2024 | 2 | 44.4 | 0 | 2025-04-16 | 0 | 0 | L-Serine; mitochondrial dysfunction; reactive oxygen species; retinal ganglion cells | DYNAMICS | l-Serine; mitochondrial dysfunction; reactive oxygen species; retinal ganglion cells | Animals; Cell Survival; Cells, Cultured; Disease Models, Animal; Flow Cytometry; Hydrogen Peroxide; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Mitochondria; Oxidative Stress; Oxygen Consumption; Reactive Oxygen Species; Retinal Ganglion Cells; Serine; 4',6 diamidino 2 phenylindole; adenosine triphosphate; beta tubulin; cellrox deep red; formazan; hoe 33342; hydrogen peroxide; mitosox; oligomycin; papain; poly dextro lysine; reactive oxygen metabolite; reagent; serine; transcription factor POU4F1; triton x 100; hydrogen peroxide; reactive oxygen metabolite; adult; aged; amplitude modulation; animal cell; Article; bioenergy; C57BL 6 mouse; cell damage; cell protection; cell viability; cell viability assay; cytoplasm; cytotoxicity; depolarization; disorders of mitochondrial functions; drug effect; flow cytometry; mitochondrial membrane potential; mitochondrial respiration; mitochondrion; mouse; nonhuman; oxidative stress; oxygen consumption rate; physically induced stress; retina ganglion cell; animal; C57BL mouse; cell culture; cell survival; disease model; drug effect; metabolism; mitochondrial membrane potential; mitochondrion; oxygen consumption; pathology | English | 2024 | 2024-10-02 | 10.1080/02713683.2024.2355661 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease Presenting as Bilateral Internuclear Ophthalmoplegia: A Case Report | Park, Jin-Sung; Lee, Hye Jin; Chun, Bo Young | Kyungpook Natl Univ, Sch Med, Dept Neurol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Ophthalmol, Daegu, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu, South Korea | 44061744500; 56008815900; 25644902100 | neurojspark@knu.ac.kr;hjllls@naver.com;byjun424@hotmail.com; | JOURNAL OF NEURO-OPHTHALMOLOGY | J NEURO-OPHTHALMOL | 1070-8022 | 1536-5166 | 44 | 4 | SCIE | CLINICAL NEUROLOGY;OPHTHALMOLOGY | 2024 | 2 | 44.4 | 0 | 2025-05-07 | 0 | 0 | aquaporin 4; immunoglobulin G; acute disseminated encephalomyelitis; adult; Article; best corrected visual acuity; brain; case report; cerebellar peduncle; cerebrospinal fluid analysis; clinical article; demyelination; human; internuclear ophthalmoplegia; intraocular pressure; male; middle aged; multiple sclerosis; Mycobacterium tuberculosis; myelin oligodendrocyte glycoprotein antibody associated disease; nuclear magnetic resonance imaging; optic neuritis; optical coherence tomography; retina macula hemorrhage; slit lamp microscopy | English | 2024 | 2024-12 | 10.1097/wno.0000000000002024 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||||
| ○ | ○ | Article | Open-chest cardiopulmonary resuscitation through a transdiaphragmatic approach in dogs: a cadaveric study to describe the surgical approach and manipulations | OBJECTIVE To describe the detailed surgical procedure for open-chest CPR (OC-CPR) through a transdiaphragmatic (TD) approach during planned laparotomy and to evaluate the procedure time and damage to organs. ANIMALS 7 mixed-breed canine cadavers. METHODS The procedure was divided into 3 stages. Durations for each of the 3 stages of the procedure and total time from diaphragmatic incision to the end of Rumel tourniquet application were recorded. Subjective assessment of ease of procedures and postprocedural physical evaluation of thoracoabdominal organs were also performed. RESULTS Mean time from diaphragmatic incision to pericardiotomy was 15.1 seconds (SD, 4.0). Performing 10 cardiac compressions took 12.0 seconds (SD, 1.8). Dissection of the aorta and application of a Rumel tourniquet took 130.4 seconds (SD, 52.2). The mean total time from start of first procedure to end of last procedure was 157.6 sec- onds (SD, 21.5). The mean length of diaphragmatic incision was 11.5 cm (SD, 2.2). Lung laceration was identified in one dog, and liver laceration was identified in another dog. The mean ease of pericardiotomy was 10, and applica- tion of a Rumel tourniquet was 4 (SD, 1.9). There was no instance of abdominal organs moving into the thoracic cavity during the procedure in any of the dogs. CLINICAL RELEVANCE Resuscitation techniques during TD OC-CPR can be performed with acceptable timing and effort, except for aortic Rumel tourniquet application, which was difficult and time consuming. Avoidable damage to thoracoabdominal organs can occur. | Kang, Jinsu; Mann, F. A. | Kyungpook Natl Univ, Coll Vet Med, Dept Vet Surg, Daegu, South Korea; Univ Missouri, Coll Vet Med, Dept Vet Med & Surg, Columbia, MO USA | Kang, Jinsu/HIK-3619-2022 | 57193611330; 7103146679 | jskang@knu.ac.kr; | AMERICAN JOURNAL OF VETERINARY RESEARCH | AM J VET RES | 0002-9645 | 1943-5681 | 85 | 9 | SCIE | VETERINARY SCIENCES | 2024 | 1.4 | 44.4 | 0 | 2025-05-07 | 0 | 0 | open-chest cardiopulmonary resuscitation; transdiaphragmatic approach; canine; pericardiotomy; rumel tourniquet | KNOWLEDGE GAP ANALYSIS; RECOVER EVIDENCE | canine; open-chest cardiopulmonary resuscitation; pericardiotomy; rumel tourniquet; transdiaphragmatic approach | Animals; Cadaver; Cardiopulmonary Resuscitation; Diaphragm; Dogs; Female; Laparotomy; Male; adult; Article; autopsy; body weight; cadaver; diaphragm; dog; laceration; laparotomy; liver injury; male; nonhuman; pericardiotomy; resuscitation; surgical approach; thoracic cavity; thoracotomy; animal; cadaver; diaphragm; female; procedures; surgery; veterinary medicine | English | 2024 | 2024-09 | 10.2460/ajvr.24.04.0109 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | The Use of the Internal Transcribed Spacer Region for Phylogenetic Analysis of the Microsporidian Parasite Enterocytozoon hepatopenaei Infecting Whiteleg Shrimp (Penaeus vannamei) and for the Development of a Nested PCR as Its Diagnostic Tool | The increasing economic losses associated with growth retardation caused by Enterocytozoon hepatopenaei (EHP), a microsporidian parasite infecting penaeid shrimp, require effective monitoring. The internal transcribed spacer (ITS)-1 region, the non-coding region of ribosomal clusters between 18S and 5.8S rRNA genes, is widely used in phylogenetic studies due to its high variability. In this study, the ITS-1 region sequence (similar to 600-bp) of EHP was first identified, and primers for a polymerase chain reaction (PCR) assay targeting that sequence were designed. A newly developed nested-PCR method successfully detected the EHP in various shrimp (Penaeus vannamei and P. monodon) and related samples, including water and feces collected from Indonesia, Thailand, South Korea, India, and Malaysia. The primers did not cross-react with other hosts and pathogens, and this PCR assay is more sensitive than existing PCR detection methods targeting the small subunit ribosomal RNA (SSU rRNA) and spore wall protein (SWP) genes. Phylogenetic analysis based on the ITS-1 sequences indicated that the Indonesian strain was distinct (86.2% nucleotide sequence identity) from other strains collected from Thailand and South Korea, and also showed the internal diversity among Thailand (N = 7, divided into four branches) and South Korean (N = 5, divided into two branches) samples. The results revealed the ability of the ITS-1 region to determine the genetic diversity of EHP from different geographical origins. | Lee, Ju Hee; Jeon, Hye Jin; Seo, Sangsu; Lee, Chorong; Kim, Bumkeun; Kwak, Dong-Mi; Rhee, Man Hee; Piamsomboon, Patharapol; Nuraini, Yani Lestari; Je, Chang Uook; Park, Seon Young; Kim, Ji Hyung; Han, Jee Eun | Kyungpook Natl Univ, Coll Vet Med, Lab Aquat Biomed, Daegu 41566, South Korea; Chulalongkorn Univ, Fac Vet Sci, Dept Vet Med, Bangkok, Thailand; Chulalongkorn Univ, Vet Med Aquat Anim Res Ctr Excellence, Bangkok, Thailand; Brackishwater Aquaculture Dev Ctr, Fish Hlth & Environm Lab, Situbondo, Indonesia; Minist Agr Food & Rural Affairs, Sejong 30110, South Korea; Chungnam Natl Univ, Coll Agr & Life Sci, Div Anim & Dairy Sci, Daejeon 34134, South Korea; Gachon Univ, Dept Food Sci & Biotechnol, Seongnam 13120, South Korea; Kyungpook Natl Univ, Inst Vet Biomed Sci, Daegu 41566, South Korea | Rhee, Man/O-5705-2016; Kim, Ji Hyung/B-7321-2011 | 59150084100; 57212193058; 59150066600; 56707749200; 57225056167; 7007148758; 57211035357; 56106906400; 57211412322; 59150088000; 57208480038; 57225000204; 57214671240 | kzh81@gachon.ac.kr;jehan@knu.ac.kr; | JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | J MICROBIOL BIOTECHN | 1017-7825 | 1738-8872 | 34 | 5 | SCIE | MICROBIOLOGY;BIOTECHNOLOGY & APPLIED MICROBIOLOGY | 2024 | 3.1 | 44.4 | 0.51 | 2025-04-16 | 1 | 1 | Enterocytozoon hepatopenaei; internal transcribed spacer; microsporidia; phylogeny; polymerase chain reaction; shrimp | LITOPENAEUS-VANNAMEI; EHP; MONODON; MARKER; DNA | Enterocytozoon hepatopenaei; internal transcribed spacer; microsporidia; phylogeny; polymerase chain reaction; shrimp | Animals; DNA Primers; DNA, Fungal; DNA, Ribosomal Spacer; Enterocytozoon; Enterocytozoon hepatopenaei; Feces; Microsporidiosis; Penaeidae; Phylogeny; Polymerase Chain Reaction; Sequence Analysis, DNA; Thailand; internal transcribed spacer; microorganism protein; small subunit ribosomal RNA; spore wall protein; unclassified drug; fungal DNA; primer DNA; ribosomal spacer DNA; Article; controlled study; Enterocytozoon hepatopenaei infection; Enterocytozoon infection; genetic variability; genome; host parasite interaction; India; Indonesia; Malaysia; nested polymerase chain reaction; nonhuman; Penaeus vannamei; phylogeny; South Korea; Thailand; animal; classification; diagnosis; DNA sequencing; Enterocytozoon; feces; genetics; isolation and purification; microbiology; microsporidiosis; parasitology; Penaeidae; polymerase chain reaction; procedures | English | 2024 | 2024-05 | 10.4014/jmb.2401.01010 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Validation of Active Compound of Terminalia catappa L. Extract and Its Anti- Inflammatory and Antioxidant Properties by Regulating Mitochondrial Dysfunction and Cellular Signaling Pathways | As chronic inflammation and oxidative stress cause various diseases in the human body, this study aimed to develop functional materials to prevent inflammation and oxidative stress. This study investigated the biological function and components of Terminalia catappa L. extract prepared using its leaves and branches (TCE). TCE was determined using ultraperformance liquid chromatographyquadrupole-time-of-flight mass spectrometry. Using RAW 264.7 mouse macrophages, inhibitory effects of the identified compounds on nitric oxide (NO) and reactive oxygen species (ROS) generation were analyzed. Therefore, alpha-punicalagin was selected as an active compound with the highest content (986.6 +/- 68.4 mu g/g) and physiological activity. TCE exhibited an inhibitory effect on lipopolysaccharide (LPS)-induced inflammatory markers, including NO, inducible nitric oxide synthase, and inflammatory cytokines without exerting cytotoxicity. Moreover, TCE prevented excessive ROS production mediated by LPS and upregulated hemeoxygenase-1 expression via the nuclear translocation of nuclear factor erythroid 2-related factor 2. Interestingly, TCE prevented LPS-induced mitochondrial membrane potential loss, mitochondrial ROS production, and dynaminrelated protein 1 phosphorylation (serine 616), a marker of abnormal mitochondrial fission. Furthermore, TCE considerably repressed the activation of LPS-induced mitogen-activated protein kinase pathway. Thus, TCE is a promising anti-inflammatory and antioxidant pharmaceutical or nutraceutical, as demonstrated via mitochondrial dysfunction and cellular signaling pathway regulation. | Paik, So Jeong; Kim, Dong-Shin; Son, Joe Eun; Bach, Tran The; Hai, Do Van; Paik, Jin-Hyub; Jo, Sangjin; Kim, Dong Joon; Jung, Sung Keun | Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Rural Dev Adm, Natl Inst Hort & Herbal Sci, Wanju 553635, South Korea; Vietnam Acad Sci & Technol, Inst Ecol & Biol Resources, 18 Hoang Quoc Viet, Hanoi, Vietnam; Korea Res Inst Biosci & Biotechnol, Int Biol Mat Res Ctr, Daejeon 34141, South Korea; Dankook Univ, Coll Med, Dept Microbiol, Cheonan 31116, South Korea; Dankook Univ, Multidrug Resistant Refractory Canc Convergence Re, Cheonan 31116, South Korea; Kyungpook Natl Univ, Res Inst Tailored Food Technol, Daegu 41566, South Korea | Kim, Dong Joon/KDN-8414-2024; Kim, Dong-Shin/KHT-5582-2024; Jung, SUNG KEUN/AGR-2623-2022 | 58161897900; 57190294593; 35362802300; 35083068900; 59157911600; 56530211700; 56226181300; 57203012616; 35310491400 | djkim407@dankook.ac.kr;skjung04@knu.ac.kr; | JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | J MICROBIOL BIOTECHN | 1017-7825 | 1738-8872 | 34 | 10 | SCIE | MICROBIOLOGY;BIOTECHNOLOGY & APPLIED MICROBIOLOGY | 2024 | 3.1 | 44.4 | 0 | 2025-05-07 | 0 | 0 | Terminalia catappa L.; functional food; inflammation; signaling pathway; mitochondria; ultra- performance liquid chromatography-quadrupole-time-of-flight mass spectrometry | OXIDATIVE STRESS; NITRIC-OXIDE; IN-VITRO; MACROPHAGES; INHIBITION; ACTIVATION; FISSION; LEAVES | functional food; inflammation; mitochondria; signaling pathway; Terminalia catappa L; ultraperformance liquid chromatography-quadrupole-time-of-flight mass spectrometry | Animals; Anti-Inflammatory Agents; Antioxidants; Cytokines; Heme Oxygenase-1; Inflammation; Lipopolysaccharides; Macrophages; Membrane Potential, Mitochondrial; Mice; Mitochondria; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Plant Extracts; Plant Leaves; RAW 264.7 Cells; Reactive Oxygen Species; Signal Transduction; Terminalia; alpha punicalagin; alpha punicalin; beta punicalagin; beta punicalin; dynamin; dynamin related protein 1; ellagic acid; gallic acid; heme oxygenase 1; inducible nitric oxide synthase; lipopolysaccharide; messenger RNA; mitogen activated protein kinase; nitric oxide; plant extract; plant medicinal product; reactive oxygen metabolite; Terminalia catappa extract; transcription factor Nrf2; unclassified drug; antiinflammatory agent; antioxidant; cytokine; heme oxygenase 1; inducible nitric oxide synthase; lipopolysaccharide; nitric oxide; plant extract; reactive oxygen metabolite; animal cell; antiinflammatory activity; antioxidant activity; Article; controlled study; cytosol; cytotoxicity test; disorders of mitochondrial functions; free radical scavenging assay; immunofluorescence; MAPK signaling; mitochondrial membrane potential; mouse; nonhuman; plant leaf; protein expression; protein phosphorylation; RAW 264.7 cell line; signal transduction; Terminalia catappa; time of flight mass spectrometry; ultra performance liquid chromatography; Western blotting; animal; chemistry; drug effect; drug therapy; inflammation; macrophage; metabolism; mitochondrion; oxidative stress; Terminalia | English | 2024 | 2024-10 | 10.4014/jmb.2407.07044 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Expert perception of sustainable energy transition: A case study of Busan Metropolitan City, South Korea | Pursuing a sustainable energy transition at the city level represents a significant strategic aspect in the worldwide movement toward climate change mitigation and carbon neutrality achievement, as global cities account for large proportions of global energy consumption and emission. The current study explores the direction of future energy production and energy systems projecting to 2050. Data were collected from experts in the energy industry and the policy of Busan Metropolitan City, and these data were analyzed via explanatory factor analysis. The results pointed to four factors of future energy production: renewable energies, fossil fuel, bioenergy, and ocean energy. Four factors of future energy systems were also identified: prioritization on mobility and building, the role of actors, interactions between energy producers and consumers, and small-scale production. In general, for future energy production and systems, the experts strongly supported low carbon-intensive energy and distributed generation, respectively. It is also important for the various actors, such as policymakers, producers, and consumers, to be integrated to achieve sustainability and carbon neutrality. An interesting result is that the political orientation of experts led to different preferences, particularly regarding nuclear energy. | Nam, Hoseok; Joo, Yejin; Nam, Hyungseok | Busan Dev Inst, Div Environm & Safety, Busan 47210, South Korea; Seoul Natl Univ, Dept Econ, Seoul 08826, South Korea; Kyungpook Natl Univ, Sch Mech Engn, Daegu 41566, South Korea | Nam, Hoseok/MTF-8047-2025 | 57198350465; 59147367800; 57190418228 | namhs0107@gmail.com;yjjoo@snu.ac.kr;namhs219@knu.ac.kr; | ENERGY FOR SUSTAINABLE DEVELOPMENT | ENERGY SUSTAIN DEV | 0973-0826 | 2352-4669 | 81 | SCIE | ENERGY & FUELS;GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY | 2024 | 4.9 | 44.6 | 0 | 2025-05-07 | 0 | 0 | Sustainability; Energy production; Energy system; Busan | RENEWABLE ENERGY; SYSTEM; FEASIBILITY; INTEGRATION; ACCEPTANCE; INNOVATION; SCENARIOS; CRITERION; STORAGE; DEMAND | Busan; Energy production; Energy system; Sustainability | Pusan [Pusan (ADS)]; Pusan [South Korea]; South Korea; Carbon; Climate change; Energy conservation; Energy utilization; Fossil fuels; Busan; Carbon neutralities; Case-studies; Energy productions; Energy systems; Energy transitions; Future energies; Metropolitan cities; South Korea; Sustainable energy; alternative energy; factor analysis; metropolitan area; perception; sustainability; Sustainable development | English | 2024 | 2024-08 | 10.1016/j.esd.2024.101465 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Opicapone to Treat Early Wearing-off in Parkinson's Disease Patients: The Korean ADOPTION Trial | Background: Increasing levodopa (L-dopa)/dopa decarboxylase inhibitor (DDCI) daily dose or adding a catechol-O-methyltransferase (COMT) inhibitor to levodopa/DDCI therapy are strategies used to manage wearing-off symptoms in Parkinson's disease (PD) patients. ObjectivesTo evaluate the COMT inhibitor opicapone versus an additional dose of levodopa to treat early wearing-off in PD patients. Methods: ADOPTION was a randomized, parallel-group, open-label, Phase 4 study conducted in Korea. At baseline, eligible patients were randomized (1:1) to opicapone 50 mg (n = 87) or L-dopa 100 mg (n = 81) (added to current L-dopa/DDCI therapy) for 4 weeks. The main efficacy endpoint was change from baseline to end of study in absolute off time. Other endpoints included changes in on time, in Movement Disorder Society-Unified Parkinson's Disease Rating Scale and 8-item PD Questionnaire scores, and the Clinical and Patient Global Impression of Improvement/Change. Results: The adjusted mean in absolute off time was significantly greater for opicapone 50 mg than for L-dopa 100 mg (-62.1 vs. -16.7 minutes; P = 0.0015). Opicapone-treated patients also reported a greater reduction in the percentage of off time (P = 0.0015), a greater increase in absolute on time (P = 0.0338) and a greater increase in the percentage of on time (P = 0.0015). There were no significant differences in other secondary endpoints. The L-dopa equivalent daily dose was significantly higher in the opicapone group (750.9 vs. 690.0 mg; P = 0.0247), when a 0.5 conversion factor is applied. Conclusions: Opicapone 50 mg was more effective than an additional 100 mg L-dopa dose at decreasing off time in patients with PD and early wearing-off. | Lee, Jee-Young; Ma, Hyeo-il; Ferreira, Joaquim J.; Rocha, Jose-Francisco; Sung, Young Hee; Song, In-Uk; Ahn, Tae-Beom; Kwon, Do Young; Cheon, Sang-Myung; Kim, Jong-Min; Lee, Chong Sik; Lee, Phil Hyu; Park, Jeong-Ho; Lee, Jae-Hyeok; Park, Mee Young; Kim, Sang Jin; Baik, Jong Sam; Choi, Seong-Min; Shin, Hae-Won; Lee, Ho-Won; Kang, Suk Yun; Jeon, Beomseok | SMG SNU Boramae Med Ctr, Dept Neurol, Seoul, South Korea; Hallym Univ Sacred Heart Hosp, Dept Neurol, Anyang, South Korea; Univ Lisbon, Fac Med, IMM Inst Med Mol Joao Lobo Antunes, Lisbon, Portugal; CNS Campus Neurol, Torres Vedras, Portugal; BIAL Portela & Ca SA, Coronado, Portugal; Gachon Univ, Gil Med Ctr, Incheon, South Korea; Catholic Univ Korea, Incheon St Marys Hosp, Incheon, South Korea; Kyung Hee Univ, Med Ctr, Seoul, South Korea; Korea Univ, Ansan Hosp, Ansan, South Korea; Dong A Univ Hosp, Busan, South Korea; Seoul Natl Univ, Bundang Hosp, Seongnam, South Korea; Asan Med Ctr, Seoul, South Korea; Severance Hosp, Seoul, South Korea; Soon Chun Hyang Univ Hosp Bucheon, Bucheon, South Korea; Pusan Natl Univ, Yangsan Hosp, Yangsan, South Korea; Yeungnam Univ, Med Ctr, Daegu, South Korea; Inje Univ, Busan Paik Hosp, Busan, South Korea; Inje Univ, Sanggye Paik Hosp, Seoul, South Korea; Chonnam Natl Univ, Chonnam Natl Univ Hosp, Med Sch, Gwangju, South Korea; Chung Ang Univ Hosp, Seoul, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Daegu, South Korea; Hallym Univ, Coll Med, Dongtan Sacred Heart Hosp, Hwaseong, South Korea; Seoul Natl Univ Hosp, Dept Neurol, Seoul, South Korea; Hallym Univ Sacred Heart Hosp, Dept Neurol 22, 22,Gwanpyeong Ro 170Beon Gil, Anyang Si 14068, Gyeonggi Do, South Korea | Lee, Jae/AAD-3704-2019; Lee, Jae-Hyeok/ISV-2976-2023; Kim, Jong-Min/J-5435-2012; Ahn, Tae-Beom/AAG-1309-2021; Ferreira, Joaquim/AAA-1837-2020 | 57225303444; 27467447200; 59971768900; 35291090100; 35278917000; 57203250730; 24340610100; 35574061200; 24329388300; 55784601300; 7410150699; 35201338900; 57202928261; 57226781339; 55361793300; 57189019510; 7006635133; 7408121966; 35314117600; 35337240700; 56849664300; 7102161956 | hima@hallym.ac.kr; | MOVEMENT DISORDERS CLINICAL PRACTICE | MOV DISORD CLIN PRAC | 2330-1619 | 11 | 6 | SCIE | CLINICAL NEUROLOGY | 2024 | 2.7 | 44.7 | 2.5 | 2025-05-07 | 5 | 5 | levodopa; opicapone; Parkinson's disease; wearing off | CATECHOL-O-METHYLTRANSFERASE; MOTOR FLUCTUATIONS; LEVODOPA; VALIDATION; INHIBITORS; ADJUNCT | levodopa; opicapone; Parkinson's disease; wearing off | catechol; catechol methyltransferase; DOPA decarboxylase inhibitor; entacapone; levodopa; opicapone; rasagiline; safinamide; selegiline; tolcapone; adult; Article; asthenia; brain depth stimulation; constipation; controlled study; dizziness; dyskinesia; female; headache; human; insomnia; Korea; major clinical study; male; middle aged; multicenter study; Parkinson disease; Personality Disorder Questionnaire; phase 4 clinical trial; prospective study; questionnaire; randomized controlled trial; rating scale; subdural hematoma | English | 2024 | 2024-06 | 10.1002/mdc3.14030 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Comprehensive analysis of somatic mutations and structural variations in domestic pig | Understanding somatic mutations and structural variations in domestic pigs (Sus scrofa domestica) is critical due to their increasing importance as model organisms in biomedical research. In this study, we conducted a comprehensive analysis through whole-genome sequencing of skin, organs, and blood samples. By examining two pig pedigrees, we investigated the inheritance and sharedness of structural variants among fathers, mothers, and offsprings. Utilizing single-cell clonal expansion techniques, we observed significant variations in the number of somatic mutations across different tissues. An in-house developed pipeline enabled precise filtering and analysis of these mutations, resulting in the construction of individual phylogenetic trees for two pigs. These trees explored the developmental relationships between different tissues, revealing insights into clonal expansions from various anatomical locations. This study enhances the understanding of pig genomes, affirming their increasing value in clinical and genomic research, and provides a foundation for future studies in other animals, paralleling previous studies in mice and humans. This approach not only deepens our understanding of mammalian genomic variations but also strengthens the role of pigs as a crucial model in human health and disease research. | Kwon, Seong Gyu; Bae, Geon Hue; Hong, Joo Hee; Choi, Jeong-Woo; Choi, June Hyug; Lim, Nam Seop; Jeon, Cheolmin; Mali, Nanda Maya; Jun, Mee Sook; Shin, Jaeeun; Kim, Jinsoo; Cho, Eun-Seok; Han, Man-Hoon; Oh, Ji Won | Yonsei Univ, Coll Med, Dept Anat, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Anat, Plus KNU Biomed Convergence Program BK21, Daegu, South Korea; Kangwon Natl Univ, Dept Anim Ind Convergence, Chunchon, South Korea; Natl Inst Anim Sci, Dept Livestock Resource Dev, Jeonbuk, South Korea; Kyungpook Natl Univ Hosp, Dept Pathol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pathol, Daegu, South Korea; Absolute DNA Inc, Daegu, South Korea | ; Kim, Jae/W-6208-2019; Oh, Ji/AAZ-3153-2020 | 57221465679; 57578938100; 57221476825; 57195933155; 57195986324; 59296799500; 59431666500; 57195987350; 7006544857; 58857534800; 35754486700; 56401493800; 57194067936; 36093206200 | mhhan1@knu.ac.kr;G1@yuhs.ac; | MAMMALIAN GENOME | MAMM GENOME | 0938-8990 | 1432-1777 | 35 | 4 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;GENETICS & HEREDITY;BIOTECHNOLOGY & APPLIED MICROBIOLOGY | 2024 | 2.7 | 44.8 | 0 | 2025-05-07 | 0 | 0 | Pig; Somatic mutation; Structural variation; Whole-genome sequencing; Pedigree | RATES; CELLS; GENERATION; DISCOVERY; FRAMEWORK; INSIGHTS | Pedigree; Pig; Somatic mutation; Structural variation; Whole-genome sequencing | Animals; Female; Genome; Genomics; Male; Mutation; Pedigree; Phylogeny; Sus scrofa; Swine; Whole Genome Sequencing; anatomical location; article; blood sampling; commercial phenomena; domestic pig; etiology; female; filtration; genome; human; inheritance; mouse; nonhuman; pedigree; phylogenetic tree; pig; progeny; somatic mutation; whole genome sequencing; animal; genetics; genome; genomics; male; mutation; phylogeny; procedures; whole genome sequencing | English | 2024 | 2024-12 | 10.1007/s00335-024-10058-z | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Cisd2 deficiency impairs neutrophil function by regulating calcium homeostasis via Calnexin and SERCA | In the context of aging, the susceptibility to infectious diseases increases, leading to heightened morbidity and mortality. This phenomenon, termed immunosenescence, is characterized by dysregulation in the aging immune system, including abnormal alterations in lymphocyte composition, elevated basal inflammation, and the accumulation of senescent T cells. Such changes contribute to increased autoimmune diseases, enhanced infection severity, and reduced responsiveness to vaccines. Utilizing aging animal models becomes imperative for a comprehensive understanding of immunosenescence, given the complexity of aging as a physiological process in living organisms. Our investigation focuses on Cisd2, , a causative gene for Wolfram syndrome, to elucidate on immunosenescence. Cisd2 knockout (KO) mice, serving as a model for premature aging, exhibit a shortened lifespan with early onset of aging-related features, such as decreased bone density, hair loss, depigmentation, and optic nerve degeneration. Intriguingly, we found that the Cisd2 KO mice present a higher number of neutrophils in the blood; however, isolated neutrophils from these mice display functional defects. Through mass spectrometry analysis, we identified an interaction between Cisd2 and Calnexin, a protein known for its role in protein quality control. Beyond this function, Calnexin also regulates calcium homeostasis through interaction with sarcoendoplasmic reticulum calcium transport ATPase (SERCA). Our study proposes that Cisd2 modulates calcium homeostasis via its interaction with Calnexin and SERCA, consequently influencing neutrophil functions. [BMB Reports 2024; 57(5): 256-261] | Choi, Un Yung; Choi, Youn Jung; Lee, Shin-Ae; Yoo, Ji-Seung | Konkuk Univ, Dept Microbiol, Sch Med, Chungju 07478, South Korea; Konkuk Univ, Res Inst Med Sci, KU Open Innovat Ctr, Sch Med, Chungju 07478, South Korea; Cedars Sinai Med Ctr, Kao Autoimmun Inst, Dept Med, Los Angeles, CA 90048 USA; Cedars Sinai Med Ctr, Dept Med, Div Rheumatol, Los Angeles, CA 90048 USA; Lerner Res Inst, Global Ctr Pathogen & Human Hlth Res, Dept Canc Biol, Infect Biol Program, Cleveland, OH 44195 USA; Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat Biores Grp, Daegu 41566, South Korea | Choi, Un Yung/GWZ-5421-2022; Hawryluk, Gregory/LLL-2080-2024; Yoo, Ji-Seung/KHD-6177-2024 | 57194039907; 55654689000; 57190621348; 59510752300 | uychoi@kku.ac.kr; | BMB REPORTS | BMB REP | 1976-6696 | 1976-670X | 57 | 5 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY | 2024 | 3.3 | 45.0 | 0.43 | 2025-04-16 | 3 | 3 | Aging; Calnexin; Cisd2; Immunosenescence; Neutrophil | Aging; Calnexin; Cisd2; Immunosenescence; Neutrophil | Animals; Calcium; Homeostasis; Membrane Proteins; Mice; Mice, Knockout; Neutrophils; Sarcoplasmic Reticulum Calcium-Transporting ATPases; calcium; membrane protein; sarcoplasmic reticulum calcium transporting adenosine triphosphatase; animal; genetics; homeostasis; knockout mouse; metabolism; mouse; neutrophil | English | 2024 | 2024 | 10.5483/bmbrep.2024-0011 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Cretaceous beetles of the Jinju Formation (Coleoptera): An overview of the Jinju Formation, its coleopteran diversity, and past and future research | Several Coleoptera fossils, including Coptoclavidae, Elateridae, Ommatidae, and Staphylinidae, were previously described from the Jinju Formation (Albian), South Korea. However, numerous beetle fossils require further research to fully understand the biodiversity of this important Cretaceous deposit. In this study, we present an overview of the diversity of Coleoptera from the Jinju Formation. Future studies on beetles of the Jinju Formation will be divided into several parts corresponding to the major lineages found in this Albian deposit. In this first part, we introduce the geological context, review previous studies related to Coleoptera fossils from the Jinju Formation, and present specimens that will undergo detailed examination in subsequent papers. | Lee, Soo Bin; Li, Yan-Da; Cai, Chenyang; Engel, Michael S.; Nam, Gi Soo; Park, Jong Kyun; Nel, Andre; Shaw, Josh Jenkins; Jouault, Corentin; Legalov, Andrei; Kundrata, Robin | Gongju Natl Univ Educ, Dept Sci Educ, 27 Ungjinro, Gongjusi, Chungcheonnamdo, South Korea; Chinese Acad Sci, State Key Lab Palaeobiol & Stratig, Nanjing Inst Geol & Palaeontol, Nanjing 210008, Peoples R China; Univ Bristol, Sch Earth Sci, Bristol Palaeobiol Grp, Life Sci Bldg,Tyndall Ave, Bristol BS8 1TQ, England; Amer Museum Nat Hist, Div Invertebrate Zool, Cent Pk West 79 th St, New York, NY 10024 USA; Univ Nacl Mayor San Marcos, Fac Ciencias Biol, Lima, Peru; Univ Nacl Mayor San Marcos, Dept Entomol, Museo Hist Nat, Ave Arenales 1256, Lima 14, Peru; Kyungpook Natl Univ, Coll Ecol & Environm Sci, Dept Appl Biol, Sangjusi, Gyeongsangbukdo, South Korea; Sorbonne Univ, Univ Antilles, Inst Systemat Evolut Biodivers ISYEB, Museum Natl Hist Nat,CNRS,EPHE, CP50,57 Rue Cuvier, F-75005 Paris, France; Univ Copenhagen, Nat Hist Museum Denmark, Copenhagen, Denmark; Univ Montpellier, Inst Sci Evolut Montpellier UMR 5554, CNRS, Pl Eugene Bataillon, F-34095 Montpellier, France; Univ Rennes, Geosci Rennes, CNRS, UMR 6118, F-35000 Rennes, France; Russian Acad Sci, Siberian Branch, Inst Systemat & Ecol Anim, Novosibirsk 630091, Russia; Altai State Univ, Lenina Prospekt 61, Barnaul 656049, Russia; Tomsk State Univ, Lenina Prospekt 36, Tomsk 634050, Russia; Palacky Univ, Fac Sci, Dept Zool, 17 Listopadu 50, Olomouc 77146, Czech Republic | Legalov, Andrei/J-8298-2018; Cai, Chenyang/KCY-5037-2024; Kundrata, Robin/AAI-5445-2021; KUNDRATA, Robin/AAI-5445-2021; Engel, Michael/C-5461-2012 | 57809940200; 57210918498; 44461012300; 57204589904; 57212227602; 37661967000; 7102516878; 54397102300; 57212658875; 35605618300; 22957920600 | dinos20000@naver.com; | JOURNAL OF ASIA-PACIFIC ENTOMOLOGY | J ASIA-PAC ENTOMOL | 1226-8615 | 1876-7990 | 27 | 2 | SCIE | ENTOMOLOGY | 2024 | 1.3 | 45.0 | 2.97 | 2025-05-07 | 3 | 3 | Insect; Coleoptera; Jinju Formation; Paleoenvironment; Cretaceous; Republic of Korea | GYEONGSANG BASIN; INSECTA COLEOPTERA; KOREA; EVOLUTION; RECORD; DEPOSITS; SPIDER; GENUS; AGES | Coleoptera; Cretaceous; Insect; Jinju Formation; Paleoenvironment; Republic of Korea | English | 2024 | 2024-06 | 10.1016/j.aspen.2024.102236 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Differential roles of N- and C-terminal LIR motifs in the catalytic activity and membrane targeting of RavZ and ATG4B proteins | Mammalian ATG8 proteins (mATG8s) are essential for selective autophagy because they recruit various proteins with LC3- interacting region (LIR) motifs to autophagic membranes. The RavZ protein, secreted by Legionella pneumophila, and mam-malian ATG4B possess functional LIR motifs that participate in lipidated mATG8 deconjugation on autophagic membranes. RavZ comprises three functional LIR motifs at the N- and C- terminal sides of its catalytic domain (CAD). This study demo-nstrated that LIR motifs at the N-terminal side of the CAD of RavZ are involved in autophagic membrane targeting and substrate recognition, while LIR motif at the C-terminal side facilitate autophagic membrane targeting. Our results also revealed that the C-terminal LIR motif in human ATG4B is pivotal in delipidating LC3B-phosphatidylethanolamine (PE), but it plays a minor role in pro-LC3B priming in the cytosol. There-fore, introducing a functional LIR motif to the N-terminal of ATG4B does not affect LC3B-PE delipidation. This study clearly described the position-dependent roles of LIR motifs in RavZ and ATG4B in cellular contexts. [BMB Reports 2024; 57(11): 497-502]. | Park, Sang-Won; Park, Ju-Hui; Choi, Haneul; Jeon, Pureum; Lee, Seung-Hwan; Shin, Won-Dong; Kim, Hun-Joo; Lee, Jin-A; Jang, Deok-Jin | Kyungpook Natl Univ, Dept Vector Entomol, Coll Ecol & Environm, Sangju 37224, South Korea; Kyungpook Natl Univ, Res Inst Invertebrate Vector, Sangju 37224, South Korea; Kyungpook Natl Univ, Coll Ecol & Environm, Dept Ecol Sci, Sangju 37224, South Korea; Hannam Univ, Coll Life Sci & Nanotechnol, Dept Biol Sci & Biotechnol, Daejeon 34054, South Korea | 57211486702; 57208208291; 57219743631; 57208213892; 57211746078; 59463350900; 59463351000; 35337365000; 22234503100 | leeja@hnu.kr;jangdj@knu.ac.kr; | BMB REPORTS | BMB REP | 1976-6696 | 1976-670X | 57 | 11 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY | 2024 | 3.3 | 45.0 | 0.78 | 2025-05-07 | 1 | 3 | AUTOPHAGY; HOST | ATG4B; Autophagy; Delipidation; Membrane localization; RavZ | Amino Acid Motifs; Autophagy; Autophagy-Related Protein 8 Family; Autophagy-Related Proteins; Bacterial Proteins; Catalytic Domain; Cell Membrane; Cysteine Endopeptidases; Humans; Legionella pneumophila; Microtubule-Associated Proteins; Phosphatidylethanolamines; ATG4B protein, human; autophagy related protein; autophagy related protein 8 family; bacterial protein; cysteine proteinase; MAP1LC3B protein, human; microtubule associated protein; phosphatidylethanolamine; cell membrane; chemistry; enzyme active site; human; Legionella pneumophila; metabolism; protein motif | English | 2024 | 2024 | 10.5483/bmbrep.2024-0084 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Glucose-dependent insulinotropic polypeptide (GIP) alleviates ferroptosis in aging-induced brain damage through the Epac/Rap1 signaling pathway | Glucose-dependent insulinotropic polypeptide (GIP), a 42-amino- acid hormone, exerts multifaceted effects in physiology, most notably in metabolism, obesity, and inflammation. Its significance extends to neuroprotection, promoting neuronal proliferation, maintaining physiological homeostasis, and inhibiting cell death, all of which play a crucial role in the context of neurodegenerative diseases. Through intricate signaling pathways involving its cognate receptor (GIPR), a member of the G protein-coupled receptors, GIP maintains cellular homeostasis and regulates a defense system against ferroptosis, an essential process in aging. Our study, utilizing GIP-overexpressing mice and in vitro cell model, elucidates the pivotal role of GIP in preserving neuronal integrity and combating age-related damage, primarily through the Epac/Rap1 pathway. These findings shed light on the potential of GIP as a therapeutic target for the pathogenesis of ferroptosis in neurodegenerative diseases and aging. | Ko, Jiwon; Jang, Soyoung; Jang, Soyeon; Park, Song; Yi, Junkoo; Choi, Dong Kyu; Kim, Seonggon; Kim, Myoung Ok; Lim, Su-Geun; Ryoo, Zae Young | Kyungpook Natl Univ, Coll Nat Sci, Sch Life Sci & Biotechnol, BK21 KNU Creat BioRes Grp 4, Daegu 41566, South Korea; Kyungpook Natl Univ, Inst Life Sci & Biotechnol, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Anim Sci & Biotechnol, Sangju 37224, South Korea; Daegu Gyeongbuk Med Innovat Fdn, Preclin Res Ctr, Daegu 41061, South Korea; Hankyong Natl Univ, Sch Anim Life Convergence Sci, Anseong 17579, South Korea; Gyeongsang Natl Univ, Div Anim Sci, Jinju 52828, South Korea; Gyeongsang Natl Univ, Inst Agr & Life Sci IALS, Jinju 52828, South Korea | Choi, dongKyu/LKL-2959-2024; RYOO, ZAEYOUNG/AAQ-1573-2020; Yi, Junkoo/JBR-8507-2023 | 57226659428; 57139360300; 57226661947; 57139047900; 56182537200; 57215816624; 55718780800; 8934745900; 56044587400; 16937104900 | sugeun624@hanmail.net;jae-woong64@knu.ac.kr;jaewoong64@knu.ac.kr; | BMB REPORTS | BMB REP | 1976-6696 | 1976-670X | 57 | 9 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY | 2024 | 3.3 | 45.0 | 0.78 | 2025-05-07 | 3 | 3 | Aging; Brain; Epac/Rap1; Ferroptosis; GIP | LIPID-PEROXIDATION | Aging; Brain; Epac/Rap1; Ferroptosis; GIP | Aging; Animals; Brain; Ferroptosis; Gastric Inhibitory Polypeptide; Guanine Nucleotide Exchange Factors; Humans; Mice; Mice, Inbred C57BL; Neurodegenerative Diseases; Neurons; rap1 GTP-Binding Proteins; Receptors, Gastrointestinal Hormone; Signal Transduction; Epac protein, mouse; gastric inhibitory polypeptide; gastric inhibitory polypeptide receptor; guanine nucleotide exchange factor; hormone receptor; Rap1 protein; aging; animal; brain; C57BL mouse; degenerative disease; drug effect; drug therapy; ferroptosis; human; metabolism; mouse; nerve cell; pathology; physiology; signal transduction | English | 2024 | 2024 | 10.5483/bmbrep.2024-0067 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Article | Impact of Alcohol on Inflammation, Immunity, Infections, and Extracellular Vesicles in Pathogenesis | Alcohol consumption is a widespread social activity with a complex and multifaceted impact on human health. Although moderate alcohol consumption has been associated with certain potential health benefits, excessive or chronic alcohol use can disrupt the body's immune balance, promote inflammation, and increase susceptibility to infections. The deleterious effects associated with alcohol toxicity include the loss of cell integrity. When cells lose their integrity, they also lose the capacity to communicate with other systems. One of the systems disturbed by alcohol toxicity is extracellular vesicle (EV)-mediated communication. EVs are critical mediators of cell -to -cell communication. They play a significant role in alcohol -induced pathogenesis, facilitating communication and molecular exchange between cells, thereby potentially contributing to alcohol -related health issues. Investigating their involvement in this context is fundamental to resolving the intricate mechanisms behind the health consequences of alcohol use and may pave the way for innovative approaches for mitigating the adverse effects of alcohol on immune health. Understanding the role of EVs in the context of alcohol -induced pathogenesis is essential for comprehending the mechanisms behind alcohol -related health issues. | Tharmalingam, Jayaraman; Gangadaran, Prakash; Rajendran, Ramya Lakshmi; Ahn, Byeong-Cheol | Univ Houston, Dept Biomed Engn, Houston, TX USA; Kyungpook Natl Univ, Dept Nucl Med, Daegu, South Korea; Kyungpook Natl Univ, BK Brain Korea 21 FOUR Fostering Outstanding Univ, Dept Biomed Sci, Daegu, South Korea; Kyungpook Natl Univ Hosp, Dept Nucl Med, Daegu, South Korea | Rajendran, Ramya/AAV-6338-2021; Gangadaran, Prakash/AAV-3102-2021 | abc2000@knu.ac.kr; | CUREUS JOURNAL OF MEDICAL SCIENCE | CUREUS J MED SCIENCE | 2168-8184 | 16 | 3 | ESCI | MEDICINE, GENERAL & INTERNAL | 2024 | 1.3 | 45.0 | 4 | extracellular vesicles; liver; infections; immunity; inflammation; alcohol | ACCESSORY CELL-FUNCTION; LUNG HOST-DEFENSE; ESCHERICHIA-COLI; LIVER-DISEASE; ETHANOL; CONSUMPTION; NEUTROPHIL; EXPRESSION; INTERLEUKIN-17; SUPPRESSES | English | 2024 | 2024-03-25 | 10.7759/cureus.56923 | 바로가기 | 바로가기 | 바로가기 |
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