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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Clinical impact of rebiopsy among patients with epidermal growth factor receptor-mutant lung adenocarcinoma in a real-world clinical setting | Background In this study, we investigated the risk factors of acquired T790M mutation among patients with lung adenocarcinoma with epidermal growth factor receptor (EGFR) tyrosine mutation who were treated with EGFR-tyrosine kinase inhibitors (TKIs). The aim was to identify the clinical impact of rebiopsy. Methods This multicenter, retrospective cohort study was conducted in South Korea from January 2007 to June 2017. Patients with adenocarcinoma with EGFR mutation who underwent rebiopsy and were treated with EGFR-TKIs were included. Results Of a total of 352 patients, T790M mutation was identified in 156 (41.9%) at the time of rebiopsy. The median duration from initial biopsy to rebiopsy was 17 months. Univariate logistic regression analysis revealed associations of exon 19 deletion (odds ratio [OR], 1.643; p = 0.026), absence of L858R (OR, 0.627; p = 0.042), and previous EGFR-TKI treatment duration (OR, 1.039; p < 0.001) with T790M mutation. Previous EGFR-TKI treatment duration (OR, 3.580; p < 0.001) was independently associated with T790M mutation. A multivariate Cox proportional hazard model revealed that brain metastasis at initial diagnosis (hazard ratio, 1.390; p = 0.050) tended to be associated with T790M mutation. Among the patients with T790M mutation at rebiopsy, the osimertinib user group (n = 90) had a better one-year survival (68.7 vs. 58.3%, p = 0.048) than the osimertinib nonuser group (n = 66). Conclusions Rebiopsy might affect the clinical course of patients with EGFR-mutant adenocarcinoma who receive EGFR-TKIs. | Nam, Yunha; Kim, Ho Cheol; Kim, Young-Chul; Jang, Seung Hun; Lee, Kye Young; Lee, Shin Yup; Lee, Sang Hoon; Lee, Sung Yong; Yoon, Seong Hoon; Ryu, Jeong-Seon; Jang, Tae Won; Chang, Yoon Soo; Kim, Seung Joon; Park, Chan Kwon; Lee, Jeong Eun; Jung, Chi Young; Choi, Chang-Min | Univ Ulsan, Asan Med Ctr, Dept Pulm & Crit Care Med, Coll Med, 88 Olymp Ro 43 Gil, Seoul 05505, South Korea; Chonnam Natl Univ, Dept Internal Med, Med Sch, Hwasun, South Korea; Chonnam Natl Univ, Hwasun Hosp, Hwasun, South Korea; Hallym Univ, Dept Pulm Allergy & Crit Care Med, Sacred Heart Hosp, Anyang, South Korea; Konkuk Univ, Dept Pulm Med, Sch Med, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Yonsei Univ, Severance Hosp, Dept Internal Med, Div Pulmonol,Coll Med, Seoul, South Korea; Korea Univ, Coll Med, Dept Internal Med, Div Pulm Allergy & Crit Care Med,Guro Hosp, Seoul, South Korea; Pusan Natl Univ, Dept Pulmonol & Allergy, Yangsan Hosp, Yangsan, South Korea; Inha Univ Hosp, Dept Internal Med, Incheon, South Korea; Kosin Univ, Dept Internal Med, Med Coll, Pusan, South Korea; Yonsei Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Catholic Univ Korea, Coll Med, Canc Res Inst, Div Pulmonol,Dept Internal Med, Seoul, South Korea; Catholic Univ Korea, Coll Med, Yeouido St Marys Hosp, Div Pulm & Crit Care Med,Dept Internal Med, Seoul, South Korea; Chungnam Natl Univ, Coll Med, Dept Internal Med, Div Pulmonol, Daejeon, South Korea; Daegu Catholic Univ, Dept Internal Med, Div Pulm & Crit Care Med, Med Ctr, Daegu, South Korea; Univ Ulsan, Asan Med Ctr, Dept Oncol, Coll Med, Seoul, South Korea | Lee, Jeong Eun/R-8689-2019; Kim, Ho Cheol/LIJ-9487-2024; Kim, Jung Oh/JDC-5061-2023; Lee, Joo Yong/ADE-2110-2022; Lee, Sang-Hoon/ABH-6210-2020; Kim, Yong-Joo/AAK-1840-2021 | 57221783242; 7410138275; 35201246200; 7402219050; 8720534800; 49863712700; 57207065392; 56734650000; 55479240500; 7401868634; 7102426031; 7501843385; 57225930594; 14623269200; 57209104622; 57223991305; 14024046800 | ccm@amc.seoul.kr; | THORACIC CANCER | THORAC CANCER | 1759-7706 | 1759-7714 | 12 | 6 | SCIE | ONCOLOGY;RESPIRATORY SYSTEM | 2021 | 3.223 | 59.9 | 0.23 | 2025-07-30 | 4 | 3 | lung cancer; EGFR‐ TKI; acquired resistance; T790M; rebiopsy | acquired resistance; EGFR-TKI; lung cancer; rebiopsy; T790M | Adenocarcinoma of Lung; Aged; Biopsy; ErbB Receptors; Female; Humans; Lung Neoplasms; Male; Middle Aged; Mutation; Retrospective Studies; afatinib; arginine; cytotoxic agent; epidermal growth factor receptor; epidermal growth factor receptor kinase inhibitor; erlotinib; gefitinib; leucine; methionine; osimertinib; threonine; EGFR protein, human; epidermal growth factor receptor; adrenal biopsy; adult; aged; Article; bone biopsy; brain biopsy; brain metastasis; bronchus biopsy; cancer survival; cohort analysis; controlled study; drug response; EGFR gene; exon; female; gene deletion; gene mutation; human; liver biopsy; lung adenocarcinoma; lung biopsy; lymph node biopsy; major clinical study; male; mutant; pericardial biopsy; pleura biopsy; pleura effusion; retrospective study; risk factor; South Korea; treatment duration; biopsy; clinical trial; lung adenocarcinoma; lung tumor; middle aged; multicenter study; mutation; procedures | English | 2021 | 2021-03 | 10.1111/1759-7714.13857 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Clinical implication of minimal presence of solid or micropapillary subtype in early-stage lung adenocarcinoma | Background We investigated the clinical features and surgical outcomes of lung adenocarcinoma with minimal solid or micropapillary (S/MP) components, with a focus on stage IA. Methods We enrolled 506 patients with lung adenocarcinoma who underwent curative resection in this study. Clinical features and surgical outcomes were compared between the groups with and without the S/MP subtype (S/MP+ and S/MP-, respectively), and between the group with an S/MP proportion of <= 5% (S/MP5) and the S/MP-. Results The S/MP subtype was present in 247 patients (48.8%); 129 (25.5%) were grouped as the S/MP5 group. The S/MP+ and S/MP5 groups had larger tumors, higher frequency of lymph node metastasis, and more advanced stages of disease than the S/MP- group (P < 0.001, all comparisons). Pleural, lymphatic, and vascular invasions occurred more frequently in the S/MP+ and S/MP5 groups (P < 0.001, all comparisons for S/MP+ vs. S/MP-; P <= 0.01, all comparisons for S/MP5 vs. S/MP-). The S/MP+ and S/MP5 groups showed a shorter time to recurrence and cancer-related death than the S/MP- group(P < 0.001, both comparisons). For stage I, the presence or absence of the S/MP subtype defined prognostic subgroups better than the stage IA/IB classification. Notably, in the multivariate analysis, the minimal S/MP component was a significant predictor of recurrence, even in stage IA. Conclusions The presence of the minimal S/MP component was a significant predictor of poor prognosis after surgery, even in stage IA patients. Clinical trials to evaluate the advantages of adjuvant chemotherapy for this subset of patients and further investigations to understand underlying biological mechanisms of poor prognosis are needed. Key points Significant findings of the study: We demonstrated that only minimal presence of solid or micropapillary component was profoundly associated with aggressive clinicopathological features and poor prognosis after complete resection even in stage IA lung adenocarcinoma. What this study adds: Our results suggest that minimal presence of these subtypes is a strong prognostic factor which should be taken into account in the risk assessment for adjuvant chemotherapy in lung adenocarcinoma. | Choi, Sun Ha; Jeong, Ji Yun; Lee, Shin Yup; Shin, Kyung Min; Jeong, Shin Young; Park, Tae-In; Do, Young Woo; Lee, Eung Bae; Seok, Yangki; Lee, Won Kee; Park, Ji Eun; Park, Sunji; Lee, Yong Hoon; Seo, Hyewon; Yoo, Seung Soo; Lee, Jaehee; Cha, Seung-Ick; Kim, Chang Ho; Park, Jae Yong | Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Lung Canc Ctr, Chilgok Hosp, 807 Hoguk Ro, Daegu 41404, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pathol, Daegu, South Korea; Kyungpook Natl Univ, Vessel Organ Interact Res Ctr, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Radiol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Nucl Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Thorac Surg, Daegu, South Korea; Soonchunhyang Univ, Gumi Hosp, Dept Thorac Surg, Gumi, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Med Res Collaborat Ctr, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Daegu, South Korea | ; Lee, You/T-6086-2019; Lee, Junseong/T-4139-2017; Lee, Jaehee/S-1697-2018; Choi, Sun Ha/HPD-7234-2023 | 57199723585; 57205472984; 49863712700; 7402410737; 36164032500; 7401801814; 57189600352; 55664096100; 37052883000; 22953484700; 57195437358; 57210251534; 57199022948; 55612130200; 56479781600; 13805476000; 35227126400; 7409873555; 58360293800 | shinyup@knu.ac.kr;jaeyong@knu.ac.kr; | THORACIC CANCER | THORAC CANCER | 1759-7706 | 1759-7714 | 12 | 2 | SCIE | ONCOLOGY;RESPIRATORY SYSTEM | 2021 | 3.223 | 59.9 | 3.43 | 2025-07-30 | 49 | 49 | Lung adenocarcinoma; micropapillary; prognosis; solid; stage IA | PROGNOSTIC-SIGNIFICANCE; INTERNATIONAL ASSOCIATION; ADJUVANT CHEMOTHERAPY; CLASSIFICATION; PATTERN; IMPACT; PREDICTORS; COMPONENTS; REVISION | Lung adenocarcinoma; micropapillary; prognosis; solid; stage IA | Adenocarcinoma of Lung; Adult; Aged; Aged, 80 and over; Female; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Prognosis; programmed death 1 ligand 1; adult; aged; Article; cancer classification; cancer mortality; cancer prognosis; cancer recurrence; cancer staging; cancer surgery; clinical feature; computer assisted tomography; controlled study; disease specific survival; female; human; lung adenocarcinoma; lymph node metastasis; major clinical study; male; postoperative period; priority journal; prognostic assessment; retrospective study; tumor invasion; very elderly; cancer staging; lung adenocarcinoma; lung tumor; middle aged; pathophysiology; prognosis | English | 2021 | 2021-01 | 10.1111/1759-7714.13754 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | High Fibrosis-4 Index Is Related with Worse Clinical Outcome in Patients with Coronavirus Disease 2019 and Diabetes Mellitus: A Multicenter Observational Study | Background: Based on recent evidence on the importance of the presence of diabetes mellitus (DM) and fibrosis-4 (FIB-4) index in coronavirus disease 2019 (COVID-19) mortality, we analyzed whether these factors could additively predict such mortality. Methods: This multicenter observational study included 1,019 adult inpatients admitted to university hospitals in Daegu. The demographic and laboratory findings, mortality, prevalence of severe disease, and duration of quarantine were compared between patients with and without DM and/or a high FIB-4 index. The mortality risk and corresponding hazard ratio (HR) were analyzed using the Kaplan-Meier method and Cox proportional hazard models. Results: The patients with DM (n=217) exhibited significantly higher FIB-4 index and mortality compared to those without DM. Although DM (HR, 2.66; 95% confidence interval [CI], 1.63 to 4.33) and a high FIB-4 index (HR, 4.20; 95% CI, 2.21 to 7.99) were separately identified as risk factors for COVID-19 mortality, the patients with both DM and high FIB-4 index had a significantly higher mortality (HR, 9.54; 95% CI, 4.11 to 22.15). Higher FIB-4 indices were associated with higher mortality regardless of DM. A high FIB-4 index with DM was more significantly associated with a severe clinical course with mortality (odds ratio, 11.24; 95% CI, 5.90 to 21.41) than a low FIB-4 index without DM, followed by a high FIB-4 index alone and DM alone. The duration of quarantine and hospital stay also tended to be longer in those with both DM and high FIB-4 index. Conclusion: Both DM and high FIB-4 index are independent and additive risk factors for COVID-19 mortality. | Kim, Sung-Woo; Jeon, Jae-Han; Moon, Jun Sung; Kim, Mi Kyung | Daegu Catholic Univ, Daegu Catholic Univ Hosp, Dept Internal Med, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Yeungnam Univ, Yeungnam Univ Hosp, Dept Internal Med, Coll Med, Daegu, South Korea; Keimyung Univ, Dongsan Hosp, Dept Internal Med, Sch Med, Daegu, South Korea | Kim, Sung-Eun/ABC-8837-2020 | 57206876109; 36910340400; 55261990400; 59124316400 | mjs7912@yu.ac.kr;mdkmk@dsmc.or.kr; | ENDOCRINOLOGY AND METABOLISM | ENDOCRINOL METAB | 2093-596X | 2093-5978 | 36 | 4 | SCIE | ENDOCRINOLOGY & METABOLISM | 2021 | 3.607 | 59.9 | 0.72 | 2025-07-30 | 10 | 9 | Non-alcoholic fatty liver disease; Diabetes mellitus; COVID-19; Mortality | MORTALITY | COVID-19; Diabetes mellitus; Mortality; Non-alcoholic fatty liver disease | adult; aged; Article; artificial ventilation; chronic kidney failure; clinical outcome; confidence interval; continuous renal replacement therapy; controlled study; coronavirus disease 2019; demography; diabetes mellitus; diabetic patient; disease association; disease severity; extracorporeal oxygenation; female; Fibrosis-4 Index; hazard ratio; high flow nasal cannula therapy; hospital admission; hospital patient; hospitalization; human; Kaplan Meier method; Korea; laboratory test; liver fibrosis; major clinical study; male; middle aged; mortality rate; mortality risk; multicenter study; nonalcoholic fatty liver; observational study; odds ratio; outcome assessment; prevalence; proportional hazards model; quarantine; retrospective study; risk factor; university hospital | English | 2021 | 2021-08 | 10.3803/enm.2021.1040 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Phase II open-label multicenter study to assess the antitumor activity of afatinib in lung cancer patients with activating epidermal growth factor receptor mutation from circulating tumor DNA: Liquid-Lung-A | Background Mutation analysis of circulating tumor DNA (ctDNA) is used for diagnosing lung cancer. This trial aimed to assess the efficacy of afatinib in treatment-naive patients with lung cancer harboring epidermal growth factor receptor mutations (EGFRm, exon 19 deletions or exon 21 point mutations) detected based on ctDNA. Methods The primary objective was the objective response rate (ORR) in the response evaluable (RE) population. EGFRm analysis of ctDNA was performed using PANA Mutype. Of the 331 patients screened, ctDNA was positive in 21% (68/331) in the detection of activating EGFRm. Among 81 subjects with tumor EGFRm, 48 showed matched EGFRm in their ctDNA (59% sensitivity). Results Therapy with afatinib 40 mg was initiated in 21 (female, 17; adenocarcinoma, 20) patients (intention-to-treat, ITT); dose modifications were made in 15 (71%). The ORR was 74% in the RE population (14/19); 11 patients showed EGFRm only in ctDNA (Group A), whereas 10 exhibited the same EGFRm in their ctDNA and tumor DNA (Group B). There was no significant difference in ORR between Groups A and B (80% and 67% RE, respectively). Median progression-free survival (PFS) was 12.0 months, and no significant difference was observed according to the final afatinib dose, type of EGFRm, and Group A versus B. After progression, T790M mutation was found in 40% (6/15) of patients, and osimertinib was used as a second-line treatment. Conclusions Afatinib showed similar ORR and PFS in patients with lung cancer harboring EGFRm in their ctDNA regardless of tumor EGFRm results. Key points Significant findings of the study Afatinib showed favorable ORR and PFS regardless of the tumor EGFR mutation status results, similar to the findings of previous trials assessing afatinib as first-line treatment of EGFR-mutated non-small cell lung cancer based on tumor genotyping. What this study adds Our findings emphasize that the survival benefit of afatinib treatment can be achieved not only by appropriate dose reduction with frequent and detailed monitoring of toxicities, but also by using noninvasive (ctDNA) assays in a real-world setting. | Park, Cheol-Kyu; Lee, Sung-Yong; Lee, Jae Cheol; Choi, Chang-Min; Lee, Shin Yup; Jang, Tae-Won; Oh, In-Jae; Kim, Young-Chul | Chonnam Natl Univ, Dept Internal Med, Med Sch, 322 Seoyang Ro, Hwasun 58128, Jeonnam, South Korea; CNU Hwasun Hosp, 322 Seoyang Ro, Hwasun 58128, Jeonnam, South Korea; Korea Univ, Dept Internal Med, Guro Hosp, Seoul, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Oncol Pulm & Crit Care Med, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Kosin Univ, Sch Med, Dept Internal Med, Gospel Hosp, Pusan, South Korea | ; Lee, Jae/AAA-2678-2021; Park, Cheol-Kyu/AAT-9872-2021; Oh, In-Jae/AAG-5919-2020; Kim, Yong-Joo/AAK-1840-2021; Lee, Joo Yong/ADE-2110-2022 | 57205721111; 56734650000; 24825051600; 14024046800; 49863712700; 7102426031; 58754601500; 35201246200 | kyc0923@jnu.ac.kr; | THORACIC CANCER | THORAC CANCER | 1759-7706 | 1759-7714 | 12 | 4 | SCIE | ONCOLOGY;RESPIRATORY SYSTEM | 2021 | 3.223 | 59.9 | 0.23 | 2025-07-30 | 5 | 5 | Afatinib; circulating tumor DNA; EGFR mutation; non‐ small cell lung carcinoma | EGFR MUTATIONS; 1ST-LINE TREATMENT; ADENOCARCINOMA; GEFITINIB; PLASMA | Afatinib; circulating tumor DNA; EGFR mutation; non-small cell lung carcinoma | Afatinib; Aged; Antineoplastic Agents; Circulating Tumor DNA; ErbB Receptors; Female; Humans; Lung Neoplasms; Male; Mutation; Prospective Studies; afatinib; circulating tumor DNA; epidermal growth factor receptor; osimertinib; afatinib; antineoplastic agent; circulating tumor DNA; epidermal growth factor receptor; acute kidney failure; aged; antineoplastic activity; Article; backache; brain metastasis; cancer growth; cancer survival; controlled clinical trial; controlled study; diarrhea; drug dose reduction; drug efficacy; drug safety; dyspnea; exon; female; gene deletion; gene mutation; human; interstitial lung disease; lung adenocarcinoma; lung cancer; lung disease; major clinical study; male; mucosa inflammation; multicenter study; mutational analysis; open study; outcome assessment; paronychia; phase 2 clinical trial; pleura effusion; pneumonia; point mutation; progression free survival; prospective study; QT prolongation; rash; sensitivity analysis; squamous cell lung carcinoma; urinary tract infection; clinical trial; genetics; lung tumor; mutation; pathology | English | 2021 | 2021-02 | 10.1111/1759-7714.13763 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Prognostic significance of genetic variants in GLUT1 in stage III non-small cell lung cancer treated with radiotherapy | Background To examine the impact of polymorphisms of glucose transporter 1 (GLUT1) gene on the prognosis of patients with stage III non-small cell lung cancer (NSCLC) who received radiotherapy. Methods Five single nucleotide polymorphisms (SNPs) (rs4658C>G, rs1385129G>A, rs3820589A>T, rs3806401A>C and rs3806400C>T) in GLUT1 gene were evaluated in 90 patients with pathologically confirmed stage III NSCLC. A total of 21 patients were treated with radiotherapy alone, 25 with sequential chemoradiotherapy, and 44 with concurrent chemoradiotherapy. The association of the genetic variations of five SNPs with overall survival (OS) and progression-free survival (PFS) was analyzed. Results Two SNPs (rs1385129 and rs3806401) were significant risk factors for OS. Three SNPs (rs1385129, rs3820589 and rs3806401) were in linkage disequilibrium. In Cox proportional hazard models, GAA haplotype was a good prognostic factor for OS (hazard ratio [HR] = 0.57, 95% confidence interval [CI]: 0.39-0.81, p = 0.002) and PFS (HR = 0.68, 95% CI: 0.47-0.99, p = 0.043), compared to variant haplotypes. The GAA/GAA diplotype was observed in 46.7% of patients; these patients showed significantly better OS (HR = 0.38, 95% CI: 0.22-0.65, p < 0.001) and PFS (HR = 0.51, 95% CI: 0.31-0.85, p = 0.009) compared to those with other diplotypes. Conclusions These results suggest that polymorphisms of GLUT1 gene could be used as a prognostic marker for patients with stage III NSCLC treated with radiotherapy. | Kang, Min Kyu; Lee, Shin Yup; Choi, Jin Eun; Baek, Sun Ah; Do, Sook Kyung; Lee, Jeong Eun; Park, Jongmoo; Yoo, Seung Soo; Choi, Sunha; Shin, Kyung Min; Jeong, Ji Yun; Park, Jae Yong | Kyungpook Natl Univ, Sch Med, Dept Radiat Oncol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biochem & Cell Biol, Daegu, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Radiol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pathol, Daegu, South Korea | KANG, MIN KYU/ACI-8824-2022; Lee, Jeong Eun/R-8689-2019 | 57201933342; 49863712700; 37107028100; 57162067900; 56333658000; 57206732333; 56180048900; 56479781600; 57199723585; 7402410737; 57205472984; 58360293800 | shinyup@knu.ac.kr;jaeyong@knu.ac.kr; | THORACIC CANCER | THORAC CANCER | 1759-7706 | 1759-7714 | 12 | 6 | SCIE | ONCOLOGY;RESPIRATORY SYSTEM | 2021 | 3.223 | 59.9 | 0.16 | 2025-07-30 | 2 | 2 | GLUT1; non-small cell lung cancer; polymorphisms; radiotherapy | ASSOCIATION; HAPLOTYPES; SURVIVAL; GROWTH | GLUT1; non-small cell lung cancer; polymorphisms; radiotherapy | Aged; Aged, 80 and over; Carcinoma, Non-Small-Cell Lung; Female; Genetic Variation; Glucose Transporter Type 1; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Polymorphism, Single Nucleotide; Prognosis; glucose transporter 1; glucose transporter 1; SLC2A1 protein, human; adult; age; aged; Article; cancer prognosis; cancer radiotherapy; cancer staging; chemoradiotherapy; female; gender; gene linkage disequilibrium; genetic association; genetic variability; GLUT1 gene; haplotype; histopathology; human; major clinical study; male; non small cell lung cancer; overall survival; progression free survival; risk factor; single nucleotide polymorphism; very elderly; cancer staging; genetic variation; genetics; lung tumor; metabolism; middle aged; non small cell lung cancer; pathology; prognosis; single nucleotide polymorphism | English | 2021 | 2021-03 | 10.1111/1759-7714.13851 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | The association between hospital case-volume and postoperative outcomes after esophageal cancer surgery: A population-based retrospective cohort study | Background Recent advances in esophageal cancer treatment require a reevaluation of the relationship between institutional case-volume and patient outcome. The aim of this study was to analyze and update the association between surgical case-volume and both in-hospital and long-term mortality after esophagectomy for esophageal cancer. Methods Data of all adult patients who received esophageal cancer surgery in Korea between 2004 and 2017 were extracted from the database of the National Health Insurance Service. Hospitals were categorized into three groups according to the average annual number of esophageal cancer surgery: low-volume (48 cases/year). Postoperative in-hospital and 1-, 3-, and 5-year mortality were analyzed according to the categorized groups using logistic regression. Results In total, 11, 346 esophageal cancer surgeries in 122 hospitals were analyzed. In-hospital mortality in the high-, medium-, and low-volume centers were 3.4%, 6.4%, and 11.1%, respectively. In-hospital mortality was significantly higher in low- volume (adjusted odds ratio, 3.91; confidence interval, 3.18-4.80; p < 0.001) and medium volume (adjusted odds ratio, 2.21; confidence interval, 1.80-2.74, p < 0.001) centers compared to high-volume centers. Patients who received esophageal cancer surgery in a low-or medium-volume center also had higher 1-, 3-, and 5-year mortality compared to patients who received the surgery in a high-volume center. Conclusions Centers with lower case-volume showed higher in-hospital mortality and long-term mortality after esophageal cancer surgery. | Kim, Bo Rim; Jang, Eun Jin; Jo, Junwoo; Lee, Hannah; Jang, Dong Yeon; Ryu, Ho Geol | Seoul Natl Univ, Seoul Natl Univ Hosp, Coll Med, Dept Anesthesiol & Pain Med, Daehak Ro 101, Seoul 03080, South Korea; Andong Natl Univ, Dept Informat Stat, Andong, Gyeongsangbuk D, South Korea; Kyungpook Natl Univ, Dept Stat, Daegu, South Korea | ; Ryu, Ho/J-5463-2012; Kim, Bo Rim/AFQ-3640-2022 | 57189683654; 37861741600; 57210425017; 55634905800; 57221838050; 7202277246 | hogeol@gmail.com; | THORACIC CANCER | THORAC CANCER | 1759-7706 | 1759-7714 | 12 | 18 | SCIE | ONCOLOGY;RESPIRATORY SYSTEM | 2021 | 3.223 | 59.9 | 0.86 | 2025-07-30 | 12 | 13 | case-volume effect; esophageal cancer; esophagectomy | MORTALITY; PREDICTORS; RESECTION | case-volume effect; esophageal cancer; esophagectomy | Adult; Aged; Aged, 80 and over; Cohort Studies; Esophageal Neoplasms; Esophagectomy; Female; Hospital Mortality; Hospitals, High-Volume; Hospitals, Low-Volume; Humans; Male; Middle Aged; Postoperative Period; Republic of Korea; Retrospective Studies; Young Adult; adjuvant therapy; adult; aged; Article; cancer surgery; cerebrovascular disease; chronic kidney failure; chronic liver disease; chronic obstructive lung disease; cohort analysis; coronary artery disease; diabetes mellitus; esophagus resection; health insurance; hospital mortality; human; hypertension; laparoscopic cholecystectomy; length of stay; male; neoadjuvant chemoradiotherapy; neoadjuvant chemotherapy; neoadjuvant therapy; pancreaticoduodenectomy; retrospective study; risk factor; treatment outcome; clinical trial; esophagus tumor; female; high volume hospital; hospital mortality; low volume hospital; middle aged; mortality; multicenter study; postoperative period; procedures; South Korea; very elderly; young adult | English | 2021 | 2021-09 | 10.1111/1759-7714.14096 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Year-Long Trend in Glycated Hemoglobin Levels in Patients with Type 2 Diabetes during the COVID-19 Pandemic | It has been suggested that the coronavirus disease 2019 (COVID-19) pandemic has had a negative impact on glycemic control in pa-tients with type 2 diabetes mellitus (T2DM). However, no study has examined yearly trends in glycated hemoglobin (HbA1c) levels after the start of the COVID-19 outbreak. Here, we performed a retrospective analysis of HbA1c concentrations during the early pe-riod of the COVID-19 outbreak (COVID-19 cohort) and then compared the yearly trend in the mean HbA1c level, along with fluc-tuations in HbA1c levels, with those during previous years (non-COVID-19 cohorts). We observed that the mean HbA1c level in pa-tients with T2DM increased during the first 6 months of the COVID-19 outbreak. After 6 months, HbA1c levels in the COVID-19 cohort returned to levels seen in the non-COVID-19 cohorts. The data suggest that vulnerable patients with T2DM should be moni-tored closely during the early period of a pandemic to ensure they receive appropriate care. | Jin, Jonghwa; Lee, Seong Wook; Lee, Won-Ki; Jeon, Jae-Han; Kim, Jung-Guk; Lee, In-Kyu; Choi, Yeon-Kyung; Park, Keun-Gyu | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, 130 Dongdeok Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Ctr Biostat, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Internal Med, 807 Hoguk Ro, Daegu 41404, South Korea | Lee, In-Kyu/AAR-6374-2021 | 57223246243; 59285294000; 57207141046; 36910340400; 16506485900; 36071537600; 35335932600; 57202558343 | ykchoi@knu.ac.kr;kpark@knu.ac.kr; | ENDOCRINOLOGY AND METABOLISM | ENDOCRINOL METAB | 2093-596X | 2093-5978 | 36 | 5 | SCIE | ENDOCRINOLOGY & METABOLISM | 2021 | 3.607 | 59.9 | 0.63 | 2025-07-30 | 7 | 8 | COVID-19; Physical distancing; Glycated hemoglobin A; Diabetes mellitus | SEASONAL-VARIATION; A1C | COVID-19; Diabetes mellitus; Glycated hemoglobin A; Physical distancing | hemoglobin A1c; adult; Article; clinical article; cohort analysis; controlled study; coronavirus disease 2019; diabetic patient; female; hemoglobin blood level; human; male; non insulin dependent diabetes mellitus; pandemic; retrospective study; trend study | English | 2021 | 2021-10 | 10.3803/enm.2021.1154 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article; Retracted Publication | RETRACTED: Inhibition of NF-κB signaling and HSP70/HSP90 proteins by newly synthesized hydrazide derivatives in arthritis model (Retracted Article) | In the current study, the N-benzylidene-4-((2-hydroxynaphthalene-1-yl) diazenyl) hydrazides (NCHDH and NTHDH) were evaluated against the Carrageenan- and CFA-induced models. During the preliminary investigation, the NCHDH and NTHDH treatment showed marked anti-inflammatory and analgesic activity against the Carrageenan-induced acute model. Once the anti-inflammatory activity was established against acute Carrageenan model, the NCHDH and NTHDH were evaluated against the chronic CFA-induced arthritis model. The NCHDH and NTHDH treatment markedly attenuated the inflammatory and analgesic parameters compared to CFA-treated group. Furthermore, the increase in the oxidative stress and attenuation of antioxidant enzymes has been reported following CFA administration. However, NCHDH and NTHDH treatment significantly induced the antioxidants and attenuated the oxidative stress markers. The CFA administration showed marked tailing of DNA; however, the NCHDH- and NTHDH-treated group preserved DNA integrity. Furthermore, the histological studies showed marked alteration in the CFA-treated group; however, the NCHDH and NTHDH treatment markedly improved the histological features. The Western blot, immunohistology, and ELISA assay revealed marked increase in the Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappa B), Jun N-terminal Kinase (JNK), TNF-alpha, and COX-2 levels; however, the NCHDH and NTHDH attenuated their expressions significantly. Similarly, the NCHDH and NTHDH significantly induced the mRNA expression levels of heat shock proteins. The computational analysis showed significant binding interaction with various protein targets via multiple hydrogens, and hydrophobic bonds. The in vivo pharmacokinetic study was also performed to assess the various pharmacokinetic parameters. In conclusion, the NCHDH and NTHDH treatment showed significant anti-arthritic activity against Carrageenan and CFA models. | Khan, Ashraf Ullah; Khan, Amna; Khan, Adnan; Shal, Bushra; Aziz, Abdul; Ahmed, Muhammad Naeem; Ul Islam, Salman; Ali, Hussain; Shehzad, Adeeb; Khan, Salman | Quaid I Azam Univ, Fac Biol Sci, Dept Pharm, Pharmacol Sci Res Lab, Islamabad, Pakistan; Univ Azad Jammu & Kashmir, Dept Chem, Muzaffarabad 13100, Pakistan; Kyungpook Natl Univ, Sch Life Sci, Coll Nat Sci, Daegu, South Korea; Natl Univ Sci & Technol NUST, Dept Biomed Engn & Sci, Sch Mech & Mfg Engn SMME, Islamabad, Pakistan | ; khan, shahan/M-6985-2017; Shehzad, Adeeb/HHN-4847-2022; Ahmed, Muhammad/ABH-6137-2020 | 57200756218; 57209213282; 57205082415; 57202263896; 59044921400; 15845156500; 56985186700; 56003879200; 36162526700; 58961283100 | skhan@qau.edu.pk; | NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY | N-S ARCH PHARMACOL | 0028-1298 | 1432-1912 | 394 | 7 | SCIE | PHARMACOLOGY & PHARMACY | 2021 | 3.195 | 60.0 | 1.76 | 2025-07-30 | 29 | 31 | Inflammation; Pain; Cytokines; Oxidative stress; Nitric oxide; Carrageenan; CFA | Carrageenan; CFA; Cytokines; Inflammation; Nitric oxide; Oxidative stress; Pain | Animals; Antirheumatic Agents; Arthritis, Experimental; Carrageenan; Edema; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Hydrazines; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Signal Transduction; acute phase protein; analgesic agent; antiinflammatory agent; C reactive protein; carrageenan; catalase; cyclooxygenase 2; dexamethasone; Evans blue; glutathione; glutathione transferase; heat shock protein 70; heat shock protein 90; hemoglobin; hydrazide derivative; immunoglobulin enhancer binding protein; interleukin 1beta; malonaldehyde; messenger RNA; myeloperoxidase; n benzylidene 4 [(2 hydroxynaphthalene 1 yl)diazenyl]hydrazide; nitric oxide; peroxidase; stress activated protein kinase; superoxide dismutase; tumor necrosis factor; unclassified drug; antirheumatic agent; carrageenan; heat shock protein 70; heat shock protein 90; hydrazine derivative; immunoglobulin enhancer binding protein; adjuvant arthritis; analgesic activity; animal experiment; animal model; animal tissue; antiinflammatory activity; area under the curve; Article; blood vessel permeability; body weight change; carrageenan-induced paw edema; chronic arthritis; comet assay; controlled study; drug protein binding; enzyme linked immunosorbent assay; erythrocyte count; hemoglobin blood level; hind paw; histopathology; hydrogen bond; hydrophobicity; immunohistochemistry; immunohistology; in vivo study; kidney function; leukocyte count; ligand binding; liver function; liver histology; male; maximum concentration; mechanical allodynia; mechanical hyperalgesia; molecular docking; mouse; mRNA expression level; muscle strength; neutrophil; NF kB signaling; nonhuman; oxidative stress; pain threshold; paw thickness; paw tissue; plasma concentration-time curve; spleen index; survival rate; thermal hyperalgesia; time to maximum plasma concentration; upregulation; volume of distribution; weight lifting; Western blotting; animal; Bagg albino mouse; chemistry; drug effect; edema; experimental arthritis; metabolism; physiology; signal transduction | English | 2021 | 2021-07 | 10.1007/s00210-021-02075-5 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | DO THE OBSERVED RELATIONS OF THE GLOBAL SEISMIC PARAMETERS DEPEND ON THE MAGNETIC ACTIVITY LEVEL? | It has been known that the global asteroseismic parameters as well as the stellar acoustic mode parameters vary with stellar magnetic activity. Some solar-like stars whose variations are thought to be induced by magnetic activity, however, show mode frequencies changing with different magnitude and phase unlike what is expected for the Sun. Therefore, it is of great importance to find out whether expected relations are consistently manifested regardless of the phase of the stellar magnetic cycle, in the sense that observations are apt to cover a part of a complete cycle of stellar magnetic activity unless observations span several decades. Here, we explore whether the observed relations of the global seismic parameters hold good regardless of the phase of the stellar magnetic cycle, even if observations only cover a part of the stellar magnetic cycle. For this purpose, by analyzing photometric Sun-as-a-star data from 1996 to 2019 covering solar cycles 23 and 24, we compare correlations of the global asteroseismic parameters and magnetic proxies for four separate intervals of the solar cycle: solar minima +/- 2 years, solar minima +4 years, solar maxima +/- 2 years, and solar maxima +4 years. We have found that the photometric magnetic activity proxy, S-ph, is an effective proxy for the solar magnetic activity regardless of the phase of the solar cycle. The amplitude of the mode envelope correlates negatively with the solar magnetic activity regardless of the phase of the solar cycle. However, relations between the central frequency of the envelope and the envelope width are vulnerable to the phase of the stellar magnetic cycle. | Kim, Ki-Beom; Chang, Heon-Young | Kyungpook Natl Univ, Dept Astron & Atmospher Sci, Daegu 41566, South Korea | 56190958000; 7407524806 | hyc@knu.ac.kr; | JOURNAL OF THE KOREAN ASTRONOMICAL SOCIETY | J KOREAN ASTRON SOC | 1225-4614 | 54 | 4 | SCIE | ASTRONOMY & ASTROPHYSICS | 2021 | 2 | 60.1 | 0.14 | 2025-07-30 | 2 | 2 | asteroseismology; Sun: activity; methods: data analysis | SOLAR-LIKE OSCILLATIONS; P-MODE FREQUENCIES; SCALING RELATION; MULTISITE CAMPAIGN; CYCLE; EXCITATION; MISSION; BISON; HELIOSEISMOLOGY; ROTATION | Asteroseismology; Methods: data analysis; Sun: activity | English | 2021 | 2021-08 | 10.5303/jkas.2021.54.4.121 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Modeling of water hyacinth growth and its role in heavy metals accumulation from unoperated old Ganga canal at Haridwar, India | The present study aimed to investigate the annual potential of water hyacinth (WH; Eichhornia crassipes) macrophyte in an un-operated/abandoned stretch of the upper Ganga canal at Haridwar, India. The study covered a 25 km long and 100 m wide stretch of the old Ganga canal which exhibits a huge WH growth every year. For this, standard field and laboratory methods were adopted to estimate the WH biomass density (Kg/m(2)), and heavy metals dynamics between canal water and macrophyte biomass. Results showed that the average annual density of WH biomass was 5.538 kg/m(2) with significant (P < 0.05) heavy metals (HMs) accumulation as 1.50 mg/Kg dw of Cd, 0.21 of mg/Kg dw of Cr, 2.19 mg/Kg dw of Cu, 28.54 mg/Kg dw of Fe, 20.79 mg/Kg dw of Mn, and 9.39 mg/Kg dw of Zn, respectively. Using a polynomial cubic model, the annual trends of WH growth and HMs accumulation in both water and biomass were also simulated. The developed models showed good R-2 and error validation results that support the prediction criteria. The findings of this study revealed that WH's growth in the un-operated stretch of the old Ganga canal located at Haridwar has high HMs accumulation and biomass production potentials. | Kumar, Vinod; Kumar, Pankaj; Eid, Ebrahem M.; Singh, Jogendra; Adelodun, Bashir; Kumar, Piyush; Kumari, Sonika; Choi, Kyung Sook | Gurukula Kangri Univ, Dept Zool & Environm Sci, Agroecol & Pollut Res Lab, Haridwar 249404, Uttarakhand, India; King Khalid Univ, Dept Biol, Coll Sci, Abha 61321, Saudi Arabia; Kafrelsheikh Univ, Dept Bot, Fac Sci, Kafr Al Sheikh 33516, Egypt; Kyungpook Natl Univ, Dept Agr Civil Engn, Daegu 41566, South Korea; Univ Ilorin, Dept Agr & Biosyst Engn, PMB 1515, Ilorin 240103, Nigeria | Kumar, P.Vinod/HKP-1552-2023; Kumar, Pankaj/AAF-2231-2019; Kumar, Promod/AAX-7650-2021; Eid, Ebrahem/O-2723-2013; Adelodun, Bashir/O-2941-2018; Kumar, Dr. Vinod/K-9971-2016 | 57200152850; 57281192700; 35794350700; 57193220273; 57193774482; 57212383972; 57226814250; 54392662900 | drvksorwal@gkv.ac.in;kumarpankajgkv@gmail.com;ebrahem.eid@sci.kfs.edu.eg;jogendrasinghpatil@gmail.com;adbash2008@gmail.com;kumarpiyushgkv@gmail.com;sonikakumari02gkv@gmail.com;ks.choi@knu.ac.kr; | RENDICONTI LINCEI-SCIENZE FISICHE E NATURALI | REND LINCEI-SCI FIS | 2037-4631 | 1720-0776 | 32 | 4 | SCIE | MULTIDISCIPLINARY SCIENCES | 2021 | 1.81 | 60.1 | 0.61 | 2025-07-30 | 10 | 11 | Ecological modeling; Heavy metals; Upper Ganga canal; Water hyacinth | EICHHORNIA-CRASSIPES; LAKE; POLLUTION; RIVER; PHYTOREMEDIATION; SEDIMENT; IMPACT; L. | Ecological modeling; Heavy metals; Upper Ganga canal; Water hyacinth | Biomass; Ecology; Hydraulic structures; Biomass density; Ecological modeling; Eichhornia crassipes; Field methods; Heavy metal accumulation; Laboratory methods; Macrophytes; Upper ganga canal; Water Hyacinth; Water hyacinth growth; Heavy metals | English | 2021 | 2021-12 | 10.1007/s12210-021-01024-x | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Safety assessment of Lactobacillus reuteri IDCC 3701 based on phenotypic and genomic analysis | Purpose Lactobacillus reuteri is one of the most largely studied human-commensal bacteria and widely used as a form of probiotics. Safety of probiotics has become increasingly important for human consumption due to increasing health-concerns in food industry. In this study, the safety of L. reuteri IDCC 3701 isolated from human breast milk was thoroughly investigated. Methods Whole-genome sequence analysis was performed to identify antibiotic resistance and toxigenicity of L. reuteri IDCC 3701. Phenotypic analysis such as minimal inhibitory concentration, beta-hemolysis, extracellular enzyme activity, and the production of biological amines and L/D-lactate, was investigated. Finally, acute oral toxicity test was performed to access L. reuteri IDCC 3701 safety. Results Although multiple resistances to gentamicin and kanamycin were observed in L. reuteri IDCC 3701, it was revealed that these resistances are intrinsic and not transferable through whole-genome analysis. In addition, various phenotypic analysis concerning hemolysis, enzyme activity, and D-lactate production did not show any negative results. Although L. reuteri IDCC 3701 harbors a histidine decarboxylase gene, no biogenic amines were detected. Finally, L. reuteri IDCC 3701 exhibited no evidence of acute toxicity according to an in vivo study. Conclusion Our findings demonstrate that L. reuteri IDCC 3701 is considered to be safe for human consumption as probiotics based on the in silico, in vitro and in vivo studies. | Lee, Bo Som; Ban, O-Hyun; Bang, Won Yeong; Chae, Seung A.; Oh, Sangki; Park, Chanmi; Lee, Minjee; Kim, Soo-Jung; Yang, Jungwoo; Jung, Young Hoon | Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Ildong Biosci, 17 Poseunggongdan Ro, Pyeongtaek Si 17957, Gyeonggi Do, South Korea; Chonnam Natl Univ, Dept Integrat Food Biosci & Biotechnol, Gwangju 61186, South Korea; Kyungpook Natl Univ, Inst Fermentat Biotechnol, Daegu 41566, South Korea | ; Jung, Young/F-1703-2013; Jung, Young Hoon/F-1703-2013 | 57219227122; 57219226382; 57208701768; 57219223373; 57219220951; 57219229140; 57221979843; 57092299400; 56076383700; 55550063700 | yjw@ildong.com;younghoonjung@knu.ac.kr; | ANNALS OF MICROBIOLOGY | ANN MICROBIOL | 1590-4261 | 1869-2044 | 71 | 1 | SCIE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY;MICROBIOLOGY | 2021 | 3.168 | 60.1 | 1.83 | 2025-07-30 | 23 | 22 | Probiotics; Lactic acid bacteria; Lactobacillus reuteri; Safety evaluation | Lactic acid bacteria; Lactobacillus reuteri; Probiotics; Safety evaluation | English | 2021 | 2021-02-15 | 10.1186/s13213-021-01622-y | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | SIMULATIONS OF TORUS REVERBERATION MAPPING EXPERIMENTS WITH SPHEREx | Reverberation mapping (RM) is an efficient method to investigate the physical sizes of the broad line region (BLR) and dusty torus in an active galactic nucleus (AGN). The Spectro-Photometer for the History of the Universe, Epoch of Reionization and Ices Explorer (SPHEREx) mission will provide multi-epoch spectroscopic data at optical and near-infrared wavelengths. These data can be used for RM experiments with bright AGNs. We present results of a feasibility test using SPHEREx data in the SPHEREx deep regions for torus RM measurements. We investigate the physical properties of bright AGNs in the SPHEREx deep field. Based on this information, we compute the efficiency of detecting torus time lags in simulated light curves. We demonstrate that, in combination with complementary optical data with a depth of similar to 20 mag in B-band, lags of <= 750 days for tori can be measured for more than similar to 200 bright AGNs. If high signal-to-noise ratio photometric data with a depth of similar to 21-22 mag are available, RM measurements are possible for up to similar to 900 objects. When complemented by well-designed early optical observations, SPHEREx can provide a unique dataset for studies of the physical properties of dusty tori in bright AGNs. | Kim, Minjin; Jeong, Woong-Seob; Yang, Yujin; Son, Jiwon; Ho, Luis C.; Woo, Jong-Hak; Im, Myungshin; Byun, Woowon | Kyungpook Natl Univ, Coll Nat Sci, Dept Astron & Atmospher Sci, Daegu 41566, South Korea; Korea Astron & Space Sci Inst, Daejeon 34055, South Korea; Univ Sci & Technol, Daejeon 34113, South Korea; Peking Univ, Kavli Inst Astron & Astrophys, Beijing 100871, Peoples R China; Peking Univ, Sch Phys, Dept Astron, Beijing 100871, Peoples R China; Seoul Natl Univ, Dept Phys & Astron, Astron Program, Seoul 08826, South Korea; Seoul Natl Univ, SNU Astron Res Ctr, Seoul 08826, South Korea | ; Kim, Minjin/AAU-9910-2020; Woo, Jong-Hak/A-2790-2014; Im, Myungshin/B-3436-2013 | 56898213300; 7102145940; 7409384232; 57226288521; 57225302746; 7401751171; 7004267711; 57216758314 | mkim.astro@gmail.com; | JOURNAL OF THE KOREAN ASTRONOMICAL SOCIETY | J KOREAN ASTRON SOC | 1225-4614 | 54 | 2 | SCIE | ASTRONOMY & ASTROPHYSICS | 2021 | 2 | 60.1 | 0.21 | 2025-07-30 | 5 | 3 | black hole physics; galaxies: active; galaxies: Seyfert; quasars: general; infrared: galaxies; dust; surveys | ACTIVE GALACTIC NUCLEI; AGN MONITORING PROJECT; BROAD-LINE REGION; SUPERMASSIVE BLACK-HOLES; HOT DUST; VARIABILITY; QUASARS; GALAXIES; MASSES; LAGS | Black hole physics; Dust; Galaxies: active; Galaxies: Seyfert; Infrared: galaxies; Quasars: general; Surveys | English | 2021 | 2021-04 | 10.5303/jkas.2021.54.2.37 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | SOMANGNET: SMALL TELESCOPE NETWORK OF KOREA | Even in an era where 8-meter class telescopes are common, small telescopes are considered very valuable research facilities since they are available for rapid follow-up or long term monitoring observations. To maximize the usefulness of small telescopes in Korea, we established the SomangNet, a network of 0.4-1.0 m class optical telescopes operated by Korean institutions, in 2020. Here, we give an overview of the project, describing the current participating telescopes, its scientific scope and operation mode, and the prospects for future activities. SomangNet currently includes 10 telescopes that are located in Australia, USA, and Chile as well as in Korea. The operation of many of these telescopes currently relies on operators, and we plan to upgrade them for remote or robotic operation. The latest SomangNet science projects include monitoring and follow-up observational studies of galaxies, supernovae, active galactic nuclei, symbiotic stars, solar system objects, neutrino/gravitational-wave sources, and exoplanets. | Im, Myungshin; Kim, Yonggi; Lee, Chung-Uk; Lee, Hee-Won; Pak, Soojong; Shim, Hyunjin; Sung, Hyun-Il; Kang, Wonseok; Kim, Taewoo; Heo, Jeong-Eun; Hinse, Tobias C.; Ishiguro, Masateru; Lim, Gu; Ly, Cuc T. K.; Paek, Gregory S. H.; Se, Jinguk; Yoon, Joh-Na; Woo, Jong-Hak; Ahn, Hojae; Cho, Hojin; Choi, Changsu; Han, Jimin; Hwang, Sungyong; Ji, Tae-Geun; Lee, Seong-Kook J.; Lee, Sumin; Lee, Sunwoo; Kim, Changgon; Kim, Dohoon; Kim, Joonho; Kim, Sophia; Jeong, Mankeun; Park, Bomi; Paek, Insu; Kim, Dohyeong; Park, Changbom | Seoul Natl Univ, SNU Astron Res Ctr, Dept Phys & Astron, Seoul 08826, South Korea; Seoul Natl Univ, Dept Phys & Astron, Astron Program, Seoul 08826, South Korea; Chungbuk Natl Univ, Dept Astron & Space Sci, Chungdae Ro, Cheongju 28644, Cheongbuk, South Korea; Chungbuk Natl Univ Observ, Eunjin Ro 29, Cheongbuk 27867, South Korea; Korea Astron & Space Sci Inst, 776 Daedeokdae Ro, Daejeon 34055, South Korea; Sejong Univ, Dept Astron & Space Sci, 209 Neungdong Ro, Seoul 05006, South Korea; Kyung Hee Univ, Sch Space Res, 1732 Deogyeong Daero, Yongin 17104, Gyeonggi Do, South Korea; Kyung Hee Univ, Dept Astron & Space Sci, 1732 Deogyeong Daero, Yongin 17104, Gyeonggi Do, South Korea; Kyungpook Natl Univ, Dept Earth Sci Educ, 80 Daehak Rho, Daegu 41566, South Korea; Natl Youth Space Ctr, Goheung 59567, Jeollanam Do, South Korea; NSFs Natl Opt Infrared Astron Res Lab, Gemini Observ, Casilla 603, La Serena, Chile; Chungnam Natl Univ, Dept Astron Space Sci & Geol, 99 Daehak Ro, Daejeon 34134, South Korea; Pusan Natl Univ, Dept Earth Sci, Busan 46241, South Korea; Korea Inst Adv Study, 85 Hoegi Ro, Seoul 02455, South Korea | Hinse, Tobias Cornelius/W-5579-2018; , Yong Jung Kim/JRW-0681-2023; Lim, Gu/MHP-9254-2025; Lee, Hee-Won/JCD-6766-2023; Kang, Wonseok/KQV-2130-2024; Hinse, Tobias/W-5579-2018; Woo, Jong-Hak/A-2790-2014; Im, Myungshin/B-3436-2013; Shim, Hyunjin/LZI-7486-2025; Pak, Soojong/E-2360-2013 | 7004267711; 7410200855; 25723619800; 23469803200; 56212344500; 14061137700; 24537938900; 55861763100; 57205660055; 56285500000; 15753241800; 9738710500; 57196357970; 57214224989; 57209205426; 57222109009; 24475688400; 7401751171; 57209206939; 55961062600; 18433745100; 57209217497; 57216527136; 56714980300; 59851294400; 57580388100; 57217383566; 57221328157; 57295662700; 57219528062; 57200876753; 57209213509; 57208868617; 57205495959; 55574223678; 7408417049 | mim@astro.snu.ac.kr; | JOURNAL OF THE KOREAN ASTRONOMICAL SOCIETY | J KOREAN ASTRON SOC | 1225-4614 | 54 | 3 | SCIE | ASTRONOMY & ASTROPHYSICS | 2021 | 2 | 60.1 | 0.28 | 2025-07-30 | 11 | 7 | telescopes; methods: observational; instrumentation: photometers; instrumentation: spectrographs; surveys | ACTIVE GALACTIC NUCLEI; HIGH-ENERGY NEUTRINOS; EARLY LIGHT CURVES; SYMBIOTIC STARS; ELECTROMAGNETIC COUNTERPART; ASTROPHYSICAL SOURCES; ROBOTIC TELESCOPE; BLACK-HOLE; EMISSION; MASS | Instrumentation: photometers; Instrumentation: spectrographs; methods: observational; Surveys; Telescopes | English | 2021 | 2021-06 | 10.5303/jkas.2021.54.3.89 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | TEMPORAL VARIATIONS OF THE GLOBAL SEISMIC PARAMETERS OF HD 49933 OVER A MAGNETIC CYCLE | It has been established that the acoustic mode parameters of the Sun and Sun-like stars vary over activity cycles. Since the observed variations are not consistent with an activity-related origin, even Sun-like stars showing out-of-phase changes of mode frequencies and amplitudes need to be carefully studied using other observational quantities. In order to test whether the presumed relations between the global seismic parameters are a signature of the stellar activity cycle, we analyze the photometric light curve of HD 49933 for which the first direct detection of an asteroseismic signature for activity-induced variations in a Sun-like star was made, using observations by the CoRoT space telescope. We find that the amplitude of the envelope significantly anti-correlates with both the maximum frequency of the envelope and the width of the envelope unless superflare-like events completely contaminate the light curve. However, even though the photometric proxy for stellar magnetic activity appears to show relations with the global asteroseismic parameters, they are statistically insignificant. Therefore, we conclude that the global asteroseismic parameters can be utilized in cross-checking asteroseismic detections of activity-related variations in Sun-like stars, and that it is probably less secure and effective to construct a photometric magnetic activity proxy to indirectly correlate the global asteroseismic parameters. Finally, we seismically estimate the mass of HD 49933 based on our determination of the large separation of HD 49933 with evolutionary tracks computed by the MESA code and find a value of about 1.2M(circle dot) and a sub-solar metallicity of Z = 0.008, which agrees with the current consensus and with asteroseismic and non-asteroseismic data. | Kim, Ki-Beom; Chang, Heon-Young | Kyungpook Natl Univ, Dept Astron & Atmospher Sci, Daegu 41566, South Korea | 56190958000; 7407524806 | hyc@knu.ac.kr; | JOURNAL OF THE KOREAN ASTRONOMICAL SOCIETY | J KOREAN ASTRON SOC | 1225-4614 | 54 | 4 | SCIE | ASTRONOMY & ASTROPHYSICS | 2021 | 2 | 60.1 | 0.07 | 2025-07-30 | 0 | 1 | asteroseismology; stars: magnetic field; methods: data analysis; stars: individual: HD 49933 | SOLAR P-MODES; MAIN-SEQUENCE; CHROMOSPHERIC ACTIVITY; MULTISITE CAMPAIGN; ABUNDANCE ANALYSIS; STARS; OSCILLATIONS; EXCITATION; BISON; ASTEROSEISMOLOGY | Asteroseismology; Methods: data analysis; Stars: individual: HD 49933; Stars: magnetic field | English | 2021 | 2021-08 | 10.5303/jkas.2021.54.4.129 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Aesthetic outcomes and complications following post-mastectomy radiation therapy in patients undergoing immediate extended latissimus dorsi flap reconstruction and implant insertion | Background: Complications of radiotherapy after implant-based reconstruction include capsular contracture development, seroma formation, and reoperation for implant removal or replacement. However, there is a lack of studies regarding aesthetic outcomes and complication rates following radiation therapy among patients undergoing latissimus dorsi (LD) flap-based reconstruction with implant insertion for volume shortage. The present study aimed to evaluate clinical and aesthetic outcomes of post-mastectomy radiation therapy (PMRT) among patients receiving both LD flap reconstruction and implant insertion. Methods: This study comprised 66 patients who underwent mastectomy and breast reconstruction between March 2014 and July 2019. Patient demographics and outcomes were compared among patients who did and did not receive PMRT. Aesthetic outcomes were compared using gross photographs. The incidence of complications, including seroma formation, flap necrosis, nipple-areola complex necrosis, hematoma development, and capsular contractures, was compared between groups. Results: No differences in aesthetic outcomes using gross photos during outpatient follow-up were observed between the radiation and control groups. No significant difference in the frequency of complications was observed between groups. Conclusions: The use of implants and LD reconstruction are inevitable in a proportion of patients due to a lack of LD flap volume. For these patients, PMRT could be safe treatment option if the necessary precautions are implemented. | Kim, Yun Hyun; Lee, Joon Seok; Park, Jongmoo; Lee, Jeeyeon; Park, Ho Yong; Yang, Jung Dug | Kyungpook Natl Univ, Sch Med, Dept Plast & Reconstruct Surg, 130 Dongdeok Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Dept Radiat Oncol, Chilgok Hosp, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Surg, Daegu, South Korea | LEE, JIN/Q-3108-2018; PARK, HO-YONG/AAP-2225-2021; Yang, Jung/R-7806-2019; Lee, Jong-Mok/KVY-9550-2024 | 57212668506; 56496041000; 56180048900; 37079213100; 56564377200; 55171704700 | lambyang@knu.ac.kr; | GLAND SURGERY | GLAND SURG | 2227-684X | 2227-8575 | 10 | 7 | SCIE | SURGERY | 2021 | 2.16 | 60.3 | 0.99 | 2025-07-30 | 4 | 6 | Latissimus dorsi (LD); silicone implant; post-mastectomy radiation; breast reconstruction | BREAST RECONSTRUCTION; TRENDS | breast reconstruction; Latissimus dorsi (LD); post-mastectomy radiation; silicone implant | English | 2021 | 2021-07 | 10.21037/gs-21-219 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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