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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Synthesis of TKX-50 via 2-Methoxyisopropyl-Protected Diazidoglyoxime as an Insensitive Intermediate | A safe synthesis of dihydroxylammonium 5,5 '-bistetrazole-1,1 '-diolate (TKX-50) has been achieved by using 2-methoxyisopropyl-protected diazidoglyoxime (MIP-DAzG) as an insensitive intermediate. The MIP group acted as a protecting group, which was quantitatively introduced into dichloroglyoxime without the need for any additives, and effectively removed during the course of the cyclization reaction used to construct the 5,5 '-bistetrazole-1,1 '-diol moiety under acidic conditions. Notably, the sensitivity results obtained for MIP-DAzG were significantly lower than those of the DAzG intermediate used in the previously reported synthesis of TKX-50. Furthermore, the sensitivity studies on MIP-DAzG indicated that the sensitivity of protected DAzG was affected by the steric hindrance around the hydroxyl group in DAzG caused by the protecting group. | Ha, Heun-Jong; Kim, Bora; Kwon, Kuktae; Kim, Seung Hee; Cho, Chang-Woo | Kyungpook Natl Univ, Res Ctr, Dept Chem & Green Nano Mat, Daegu 41566, South Korea; Agcy Def Dev, Directorate 2, R&D Inst 4, Daejeon 34186, South Korea | Bin Kim, Hong/J-5452-2012 | 57205079378; 57211371068; 57193276575; 55855364800; 7403100021 | cwcho@knu.ac.kr; | PROPELLANTS EXPLOSIVES PYROTECHNICS | PROPELL EXPLOS PYROT | 0721-3115 | 1521-4087 | 46 | 5 | SCIE | CHEMISTRY, APPLIED;ENGINEERING, CHEMICAL | 2021 | 2.134 | 58.2 | 0.31 | 2025-07-30 | 8 | 8 | Explosive; TKX-50; Insensitivity; Diazidoglyoxime; Protecting group | Diazidoglyoxime; Explosive; Insensitivity; Protecting group; TKX-50 | Additives; Acidic conditions; Cyclization reactions; Hydroxyl groups; Protecting group; Sensitivity studies; Steric hindrances; Cyclization | English | 2021 | 2021-05 | 10.1002/prep.202000287 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Article | Electrocardiographic Manifestations in Patients with COVID-19: Daegu in South Korea | Background and Objectives: As the coronavirus disease 2019 (COVID-19) spreads worldwide, cardiac injury in patients infected with COVID-19 becomes a significant concern. Thus, this study investigates the impact of several electrocardiogram (ECG) parameters and disease severity in COVID-19 patients. Methods: Seven medical centers in Daegu admitted 822 patients with COVID-19 between February and April 2020. This study examined 267 patients among them who underwent an ECG test and evaluated their biochemical parameters like C-reactive protein (CRP), log N-terminal pro-B-type Natriuretic Peptide (NT-proBNP), cardiac enzyme, and ECG parameters (heart rate, PR interval, QRS interval, T inversion, QT interval, and Tpe [the interval between peak to end in a T wave]). Results: Those patients were divided into 3 groups of mild (100 patients), moderate (89 patients), and severe (78 patients) according to clinical severity score. The level of CRP, log NT-proBNP, and creatinine kinase-myocardial band were significantly increased in severe patients. Meanwhile, severe patients exhibited prolonged QT intervals (QTc) and Tpe (Tpe-c) compared to mild or moderate patients. Moreover, deceased patients (58; 21.7%) showed increased dispersion of QTc and Tpe-c compared with surviving patients (78.2 +/- 41.1 vs. 40.8 +/- 24.6 ms and 60.2 +/- 37.3 vs. 40.8 +/- 24.5 ms, both p<0.05, respectively). The QTc dispersion of more than 56.1 ms could predict the mortality in multivariate analysis (Odd ratio, 11.55; 95% confidence interval, 3.746-42.306). Conclusions: COVID-19 infections could involve cardiac injuries, especially cardiac repolarization abnormalities. A prolonged QTc dispersion could be an independent predictable factor of mortality. | Bae, Han-Joon; Cho, Hyun Jun; Lee, Chan-Hee; Bae, Myung Hwan; Park, Hyoung-Seob; Jung, Byung Chun; Shin, Dong-Gu; Cho, Yongkeun; Hwang, Jongmin; Han, Seongwook; Park, Kyu-Hwan; Jang, Se Yong; Lee, Young Soo | Daegu Catholic Univ, Coll Med, Div Cardiol, 33 Duryugongwon Ro 17 Gil, Daegu 42472, South Korea; Daegu Fatima Gen Hosp, Div Cardiol, Daegu, South Korea; Yeungnam Univ, Coll Med, Div Cardiol, Daegu, South Korea; Kyungpook Natl Univ, Div Cardiol, Daegu, South Korea; Keimyung Univ, Dongsan Med Ctr, Div Cardiol, Daegu, South Korea; Daegu Vet Hosp, Div Cardiol, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Div Cardiol, Daegu, South Korea | mdleeys@cu.ac.kr; | KOREAN CIRCULATION JOURNAL | KOREAN CIRC J | 1738-5520 | 1738-5555 | 51 | 10 | SCIE | CARDIAC & CARDIOVASCULAR SYSTEMS | 2021 | 3.101 | 58.4 | 3 | Coronavirus; COVID-19; ECG | INTERVAL | English | 2021 | 2021-10 | 10.4070/kcj.2021.0116 | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | ○ | Article | Realtime fire detection using CNN and search space navigation | Intelligent search techniques and an intelligent agent for smart search are useful in many application domains. We develop a state space navigational model for intelligent agents aimed at industrial surveillance from fire hazards. Our focus is on fire detection using the convolution neural network then proactively search the area which is more likely to have routes toward the target. This problem can be simulated into an optimization problem over a state space, which can be figure out effectively through a greedy algorithm. We also compare our approach with both uninformed and informed search algorithms. We evaluate our proposed system using various search algorithms for search and rescue agent. The analysis of the results obtained demonstrate the efficiency of the system. | Rahmatov, Nematullo; Paul, Anand; Saeed, Faisal; Seo, Hyuncheol | Kyungpook Natl Univ, Daegu, South Korea; Kyungpook Natl Univ, Sch Comp Sci & Engn, Daegu, South Korea | Paul, Anand/V-6724-2017; Seo, Hyuncheol/ABC-5117-2020 | 57203635963; 56650522400; 58165089300; 56083741500 | charles@knu.ac.kr; | JOURNAL OF REAL-TIME IMAGE PROCESSING | J REAL-TIME IMAGE PR | 1861-8200 | 1861-8219 | 18 | 4 | SCIE | COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE;ENGINEERING, ELECTRICAL & ELECTRONIC;IMAGING SCIENCE & PHOTOGRAPHIC TECHNOLOGY | 2021 | 2.293 | 58.5 | 1.22 | 2025-07-30 | 6 | 10 | Artificial intelligence; Intelligent agent; Navigational maneuver; Neural networks; Search algorithm | NETWORK; SURVEILLANCE; TIME | Artificial intelligence; Intelligent agent; Navigational maneuver; Neural networks; Search algorithm | Fire detectors; Fire hazards; Learning algorithms; Convolution neural network; Greedy algorithms; Industrial surveillance; Intelligent search; Navigational modeling; Optimization problems; Search Algorithms; Search and rescue; Intelligent agents | English | 2021 | 2021-08 | 10.1007/s11554-021-01153-4 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Precontoured Plate Fixation for Incomplete Atypical Diaphyseal Fracture of Femur using Three-Dimensional Printing Rapid Prototyping: Two Cases Reports | Background Reconstruction intramedullary nail spanning the whole length of the femur has been the gold standard treatment for complete atypical diaphyseal fractures of the femur (ADF). However, in cases of incomplete ADF combined with severe bowing, this approach might have complications and lead to iatrogenic complete fracture. We report two cases of incomplete ADF with severe bowing using a precontoured plate (PCP) after rapid prototyping (RP) of the deformed femurs with three-dimensional printing (3DP) technology. Case presentation Two patients presented with gradually worsening thigh pain, especially during walking. The patients had been using bisphosphonates for 4 and 10 years, respectively. Radiography showed an incomplete fracture in the lateral cortex of the right femur shaft. The lateral bowing angles measured in the affected femurs were 15 degrees and 14 degrees, and the anterior bowing angles were 20 degrees and 16 degrees, respectively. In bone scans, both patients showed hot uptake in the right mid-shaft of the femur. Preoperatively, the affected femur of the patient was reconstructed by 3DP RP using CT, and the plate was bent to the shape of the bone model. The ADF was fixed with a PCP using the minimally invasive plate osteosynthesis technique. Both patients were encouraged to start full weight-bearing and return to their preinjury activity level in daily life immediately after surgery. At 2 years postoperatively, radiography showed healing of the fracture site without recurrence of thigh pain and implant-related problems. Conclusion Although intramedullary nailing is the standard surgical treatment for complete ADF, PCP using 3DP RP could be an effective treatment option for incomplete ADF with severely curved femur. | Won, Heejae; Baek, Seung-Hoon; Kim, Cheol-Hwan; Kim, Dong-Hyeon; Yoon, Jee-Wook; Kim, Shin-Yoon | Kyungpook Natl Univ Hosp, Dept Orthopaed Surg, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Orthopaed Surg, Daegu, South Korea; Inst Adv Convergence Technol, Dept 3D Convergence Technol, Daegu, South Korea | Kim, Soo/J-5411-2012 | 57209207044; 56232924900; 57148704100; 57220190997; 57188967905; 26663842900 | insideme@paran.com; | ORTHOPAEDIC SURGERY | ORTHOP SURG | 1757-7853 | 1757-7861 | 13 | 1 | SCIE | ORTHOPEDICS | 2021 | 2.279 | 58.7 | 0.45 | 2025-07-30 | 3 | 3 | Diaphyseal femoral fracture; Incomplete fracture; Precontoured plate; Minimally invasive surgery; Three‐ dimensional printing | Diaphyseal femoral fracture; Incomplete fracture; Minimally invasive surgery; Precontoured plate; Three-dimensional printing | alendronic acid; bisphosphonic acid derivative; ibandronic acid; parathyroid hormone[1-34]; adult; aged; Article; bone bowing; bone density; bone metabolism; bone scintiscanning; case report; clinical article; distal radius fracture; drug substitution; drug withdrawal; female; femoral neck fracture; femoral shaft; femur; femur fracture; femur intertrochanteric fracture; follow up; fracture healing; human; lumbar spine; male; operation duration; osteogenesis imperfecta; osteoporosis; osteosynthesis; physical examination; plate fixation; proximal femur; pubis symphysis; rapid prototyping; single photon emission computed tomography; three dimensional printing; total knee arthroplasty; walking | English | 2021 | 2021-02 | 10.1111/os.12867 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Bayesian Multiple Change-Points Detection in a Normal Model with Heterogeneous Variances | This study considers the problem of multiple change-points detection. For this problem, we develop an objective Bayesian multiple change-points detection procedure in a normal model with heterogeneous variances. Our Bayesian procedure is based on a combination of binary segmentation and the idea of the screening and ranking algorithm (Niu and Zhang in Ann Appl Stat 6:1306-1326, 2012). Using the screening and ranking algorithm, we can overcome the drawbacks of binary segmentation, as it cannot detect a small segment of structural change in the middle of a large segment or segments of structural changes with small jump magnitude. We propose a detection procedure based on a Bayesian model selection procedure to address this problem in which no subjective input is considered. We construct intrinsic priors for which the Bayes factors and model selection probabilities are well defined. We find that for large sample sizes, our method based on Bayes factors with intrinsic priors is consistent. Moreover, we compare the behavior of the proposed multiple change-points detection procedure with existing methods through a simulation study and two real data examples. | Kang, Sang Gil; Lee, Woo Dong; Kim, Yongku | Sangji Univ, Dept Comp & Data Informat, Wonju 26339, South Korea; Daegu Haany Univ, Premajor Cosmet & Pharmaceut, Gyongsan 38610, South Korea; Kyungpook Natl Univ, Dept Stat, Daegu 41566, South Korea | 56119861400; 8328822200; 47962102500 | sangkg@sangji.ac.kr;wdlee@dhu.ac.kr;kim.1252@knu.ac.kr; | COMPUTATIONAL STATISTICS | COMPUTATION STAT | 0943-4062 | 1613-9658 | 36 | 2 | SCIE | STATISTICS & PROBABILITY | 2021 | 1.405 | 58.8 | 0 | 2025-07-30 | 1 | 1 | Bayes factor; Binary segmentation; Intrinsic prior; Multiple change-points; Screening and ranking algorithm | BINARY SEGMENTATION; ONLINE INFERENCE; NUMBER; SELECTION; DEFAULT | Bayes factor; Binary segmentation; Intrinsic prior; Multiple change-points; Screening and ranking algorithm | English | 2021 | 2021-06 | 10.1007/s00180-020-01054-3 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Article | Large-strain consolidation analysis of PVD-installed soft soil considering the discharge capacity variation according to depth and time | Purpose The consolidation behavior of prefabricated vertical drain (PVD)-installed soft deposits mainly depends on the PVD performance. The purpose of this study is to propose a numerical solution for the consolidation of PVD-installed soft soil using the large-strain theory, in which the reduction of discharge capacity of PVD according to depth and time is simultaneously considered. Design/methodology/approach The proposed solution also takes into account the general constitute relationship of soft soil. Subsequently, the proposed solution is applied to analyze and compare with the monitoring data of two cases, one is the experimental test and another is the test embankment in Saga airport. Findings The results show that the reduction of PVD discharge capacity according to depth and time increased the duration required to achieve a certain degree of consolidation. The consolidation rate is more sensitive to the reduction of PVD discharge capacity according to time than that according to the depth. The effects of the reduction of PVD discharge capacity according to depth are more evident when PVD discharge capacity decreases. The predicted results using the proposed numerical solution were validated well with the monitoring data for both cases in verification. Research limitations/implications In this study, the variation of PVD discharge capacity is only considered in one-dimensional consolidation. However, it is challenging to implement a general expression for discharge capacity variation according to time in the two-dimensional numerical solution (two-dimensional plane strain model). This is the motivation for further study. Practical implications A geotechnical engineer could use the proposed numerical solution to predict the consolidation behavior of the drainage-improved soft deposit considering the PVD discharge capacity variation. Originality/value The large-strain consolidation of PVD-installed soft deposits could be predicted well by using the proposed numerical solution considering the PVD discharge capacity variations according to depth and time. | Ba-Phu Nguyen; Pradhan, Ananta Man Singh; Tan Hung Nguyen; Nhat-Phi Doan; Van-Quang Nguyen; Thanh-Canh Huynh | Ind Univ Ho Chi Minh City, Dept Civil Engn, Ho Chi Minh City, Vietnam; Govt Nepal, Minist Energy Water Resources & Irrigat, Water Resource Res & Dev Ctr, Kathmandu, Nepal; Can Tho Univ Technol, Dept Civil Engn, Can Tho, Vietnam; Kyungpook Natl Univ, Dept Civil Engn, Daegu, South Korea; Hanyang Univ, Dept Civil & Environm Engn, Seoul, South Korea; Vinh Univ, Dept Civil Engn, Vinh, Vietnam; Duy Tan Univ, Dept Civil Engn, Da Nang, Vietnam; Duy Tan Univ, Ctr Construct Mech & Mat, Inst Res & Dev, Da Nang, Vietnam | Van, Quang/AAM-1479-2020; Doan, Nhat-Phi/IAM-1883-2023; DOAN, NHAT-PHI/IAM-1883-2023; Nguyen, Ba-Phu/J-7402-2019; Nguyen, Hung/KIK-7714-2024; Pradhan, Ananta Man Singh/A-8259-2019 | nguyenbaphu@iuh.edu.vn; | ENGINEERING COMPUTATIONS | ENG COMPUTATION | 0264-4401 | 1758-7077 | 38 | 4 | SCIE | COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS;ENGINEERING, MULTIDISCIPLINARY;MATHEMATICS, INTERDISCIPLINARY APPLICATIONS;MECHANICS | 2021 | 1.675 | 58.8 | 16 | Soft soil; Consolidation; Discharge capacity; Prefabricated vertical drain; Large-strain theory | PREFABRICATED VERTICAL DRAINS; NON-LINEAR CONSOLIDATION; RADIAL CONSOLIDATION; SATURATED CLAYS; EMBANKMENTS; DEPOSITS | English | 2021 | 2021-06-17 | 10.1108/ec-05-2020-0253 | 바로가기 | 바로가기 | 바로가기 | |||||||||
| ○ | ○ | Article | Lifetime cancer risks from occupational radiation exposure among workers at interventional radiology departments | Purpose Interventional medical radiation workers represent an under-studied population worldwide, although they receive relatively high occupational radiation doses. This study aimed to estimate the lifetime cancer risk from occupational radiation exposure among workers at interventional radiology departments. Methods A field survey of interventional medical workers in nationwide branches of the Korean Society of Interventional Radiology was conducted in 2017. Organ-specific radiation doses were estimated using national dose registry data and conversion coefficients provided by the International Commission on Radiological Protection. Lifetime attributable risk (LAR) and lifetime fractional risk (LFR) were calculated based on realistic exposure scenarios using a radiation risk assessment tool. Results LARs from occupational radiation exposure until the age of retirement for all cancers combined were 338 (90.3-796.1), 121 (33.5-288.7), and 156 (41.1-390.6) per 100,000 individuals for male radiologists, male radiologic technologists, and female nurses, respectively. LFR for all cancers combined ranged from 0.22% (0.06-0.53) to 0.63% (0.17-1.47). Regarding the organ site, the highest LAR and LFR among all groups were observed for thyroid cancer. Conclusion This study provides timely evidence of potential cancer burden from the current levels of occupational radiation exposure among workers at interventional radiology departments. The risks varied by occupational groups, and workers, particularly interventional radiologists, need to be carefully monitored for radiation. | Lee, Won Jin; Bang, Ye Jin; Cha, Eun Shil; Kim, Young Min; Cho, Sung Bum | Korea Univ, Dept Prevent Med, Coll Med, 73 Goryeodae Ro, Seoul 02841, South Korea; Kyungpook Natl Univ, Dept Stat, Daegu, South Korea; Korea Univ, Anam Hosp, Dept Radiol, Coll Med, Seoul, South Korea | Lee, JooSang/KLC-3096-2024 | 55641918400; 56985424800; 24436753300; 56035273800; 57195968550 | leewj@korea.ac.kr; | INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH | INT ARCH OCC ENV HEA | 0340-0131 | 1432-1246 | 94 | 1 | SCIE | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | 2021 | 2.851 | 58.8 | 1.07 | 2025-07-30 | 20 | 19 | Health professionals; lifetime attributable risk; Neoplasm; Occupation | PROTECTION | Health professionals; lifetime attributable risk; Neoplasm; Occupation | Adult; Female; Humans; Male; Middle Aged; Neoplasms, Radiation-Induced; Nurse Specialists; Occupational Diseases; Occupational Exposure; Radiation Exposure; Radiologists; Radiology, Interventional; Republic of Korea; Risk; Thyroid Neoplasms; adult; female; human; interventional radiology; male; middle aged; nurse specialist; occupational disease; occupational exposure; radiation exposure; radiation induced neoplasm; radiologist; risk; South Korea; thyroid tumor | English | 2021 | 2021-01 | 10.1007/s00420-020-01569-8 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Lupeol-induced nitric oxide elicits apoptosis-like death within Escherichia coli in a DNA fragmentation-independent manner | Lupeol is known to be plentiful in fruits or plant barks and has an antimicrobial effect, however, its mode of action(s) has yet to be determined. To elucidate lupeol generates nitric oxide (NO), which is recognized for possessing an antimicrobial activity, intracellular NO was measured in Escherichia coli using DAF-FM. Using the properties of NO passing through plasma membrane easily, increased malondialdehyde levels have shown that lupeol causes lipid peroxidation, and the resulting membrane depolarization was confirmed by DiBAC4(3). These data indicated that lupeol-induced NO is related to the destruction of bacterial membrane. Further study was performed to examine whether NO, known as a cell proliferation inhibitor, affects bacterial cell division. As a result, DAPI staining verified that lupeol promotes cell division arrest, and followed by early apoptosis is observed in Annexin V/PI double staining. Even though these apoptotic hallmarks appeared, the endonuclease failed to perform properly with supporting data of decreased intracellular Mg2+ and Ca2+ levels without DNA fragmentation, which is confirmed using a TUNEL assay. These findings indicated that lupeol-induced NO occurs DNA fragmentation-independent bacterial apoptosis-like death (ALD). Additionally, lupeol triggers DNA filamentation and morphological changes in response to DNA repair system called SOS system. In accordance with the fact that ALD deems to SOS response, and that the RecA is considered as a caspase-like protein, increase in caspase-like protein activation occurred in E. coli wild-type, and no Delta RecA mutant. In conclusion, these results demonstrated that the antibacterial mode of action(s) of lupeol is an ALD while generating NO. | Kim, Heesu; Lee, Dong Gun | Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat Bio Res Grp, Daegu 41566, South Korea | Lee, Dong-Gun/IWD-9833-2023 | 57219859173; 55668060900 | dglee222@knu.ac.k;dglee222@knu.ac.kr; | BIOCHEMICAL JOURNAL | BIOCHEM J | 0264-6021 | 1470-8728 | 478 | 4 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY | 2021 | 3.766 | 58.8 | 0.34 | 2025-07-30 | 6 | 7 | LIPID-PEROXIDATION; CELL-DEATH; MEMBRANE DEPOLARIZATION; ANTIFUNGAL ACTIVITY; DIETARY TRITERPENE; INHIBITION; ENDONUCLEASE; MECHANISMS; GROWTH; CYCLE | Anti-Bacterial Agents; Apoptosis; Calcium; Cell Division; Cell Membrane; DNA Fragmentation; DNA, Bacterial; DNA-Binding Proteins; Drug Evaluation, Preclinical; Escherichia coli; Escherichia coli Proteins; Lipid Peroxidation; Magnesium; Membrane Lipids; Membrane Potentials; NG-Nitroarginine Methyl Ester; Nitric Oxide; Norfloxacin; Pentacyclic Triterpenes; Rec A Recombinases; SOS Response, Genetics; antimitotic agent; caspase; lupeol; magnesium ion; malonaldehyde; nitric oxide; thiobarbituric acid reactive substance; antiinfective agent; bacterial DNA; calcium; DNA binding protein; Escherichia coli protein; lupeol; magnesium; membrane lipid; n(g) nitroarginine methyl ester; nitric oxide; norfloxacin; pentacyclic triterpene; RecA protein; recA protein, E coli; antibacterial activity; apoptosis; Article; bacterial cell; bacterial membrane; calcium cell level; cell cycle arrest; cell division; cell membrane; cell proliferation; cell suspension; chromosome condensation; controlled study; DNA cleavage; DNA degradation; DNA fragmentation; DNA repair; Enterococcus faecalis; Enterococcus faecium; Escherichia coli; human; lipid peroxidation; membrane depolarization; nonhuman; priority journal; Pseudomonas aeruginosa; Salmonella enterica serovar Enteritidis; Salmonella enterica serovar Typhimurium; sos response (genetics); TUNEL assay; apoptosis; biosynthesis; DNA fragmentation; drug effect; Escherichia coli; membrane potential; metabolism; physiology; preclinical study | English | 2021 | 2021-02 | 10.1042/bcj20200925 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Objective Bayesian analysis for generalized exponential stress-strength model | In reliability studies, a stress-strength model is often used to analyze a system that fails whenever the applied stress is greater than the strength. Statistical inference of reliability is widely used in a number of areas, such as engineering, clinical trials, and quality control. In addition to the common stress-strength model with one stress and one strength, the reliability of more complex systems has also been studied. In this study, we consider the reliability of a generalized stress-strength model that consists of a serial system with one stress and multiple strengths. We then develop the probability matching priors and reference priors for a generalized exponential stress-strength model. We demonstrate that the two-group reference prior and Jeffreys prior are not a matching prior. Through a simulation study and real data example, we also demonstrate that the proposed probability matching priors match the target coverage probabilities in a frequentist sense even for a small sample size. | Kang, Sang Gil; Lee, Woo Dong; Kim, Yongku | Sangji Univ, Dept Comp & Data Informat, Wonju 26339, South Korea; Daegu Haany Univ, Premajor Cosmet & Pharmaceut, Kyungsan 38610, South Korea; Kyungpook Natl Univ, Dept Stat, Daegu 41566, South Korea | 56119861400; 8328822200; 47962102500 | sangkg@sangji.ac.kr;wdlee@dhu.ac.kr;kim.1252@knu.ac.kr; | COMPUTATIONAL STATISTICS | COMPUTATION STAT | 0943-4062 | 1613-9658 | 36 | 3 | SCIE | STATISTICS & PROBABILITY | 2021 | 1.405 | 58.8 | 0.68 | 2025-07-30 | 8 | 7 | Bayesian analysis; Exponential distribution; Generalized stress– strength model; Matching prior; Reference prior | FREQUENTIST VALIDITY; SYSTEM; PRIORS | Bayesian analysis; Exponential distribution; Generalized stress–strength model; Matching prior; Reference prior | English | 2021 | 2021-09 | 10.1007/s00180-021-01083-6 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Genetic Polymorphisms in Activating Transcription Factor 3 Binding Site and the Prognosis of Early-Stage Non-Small Cell Lung Cancer | Background: Activating transcription factor 3 (ATF3) plays a significant role in cancer development and progression. We investigated the association between variants in expression quantitative trait loci (eQTLs) within ATF3 binding regions and the prognosis of non-small cell lung cancer (NSCLC) after surgery. Methods: A total of 772 patients with NSCLC who underwent curative surgery were enrolled. Using a public database (http://galaxyproject.org), we selected 104 single nucleotide polymorphisms (SNPs) in eQTLs in the ATF3 binding regions. The association of those SNPs with disease-free survival (DFS) was evaluated. Results: Among those SNPs, HAX1 rs11265425T>G was associated with significantly worse DFS (aHR = 1.30, 95% CI = 1.00-1.69, p = 0.05), and ME3 rs10400291C>A was associated with significantly better DFS (aHR = 0.66, 95% CI = 0.46-0.95, p = 0.03). Regarding HAX1 rs11265425T>G, the significant association remained only in adenocarcinoma, and the association was significant only in squamous cell carcinoma regarding ME3 rs10400291C>A. ChIP-qPCR assays showed that the two variants reside in active enhancers where H3K27Ac and ATF3 binding occurs. Promoter assays showed that rs11265425 G allele had significantly higher HAX1 promoter activity than T allele. HAX1 RNA expression was significantly higher in tumor than in normal lung, and higher in rs11265425 TG+GG genotypes than in TT genotype. Conversely, ME3 expression was significantly lower in tumor than in normal lung, and higher in rs10400291 AA genotype than in CC+CA genotypes. Conclusions: In conclusion, this study shows that the functional polymorphisms in ATF3 binding sites, HAX1 rs11265425T>G and ME3 rs10400291C>A are associated with the clinical outcomes of patients in surgically resected NSCLC. | Kang, Hyo-Gyoung; Park, Ji Eun; Lee, Shin Yup; Choi, Jin Eun; Do, Sook Kyung; Hong, Mi Jeong; Lee, Jang Hyuck; Jeong, Ji Yun; Do, Young Woo; Lee, Eung Bae; Shin, Kyung Min; Lee, Won Ki; Choi, Sun Ha; Lee, Yong Hoon; Seo, Hye won; Yoo, Seung Soo; Lee, Jaehee; Cha, Seung Ick; Kim, Chang Ho; Cho, Sukki; Jheon, Sanghoon; Park, Jae Yong | Kyungpook Natl Univ, Sch Med, Dept Biochem, Daegu, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Lung Canc Ctr, Chilgok Hosp, 807 Hoguk Ro, Daegu 41404, South Korea; Kyungpook Natl Univ, Dept Biomed Sci, BK21 Plus KNU Biomed Convergence Program, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pathol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Thorac Surg, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Radiol, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Med Res Collaborat Ctr, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Daegu, South Korea; Seoul Natl Univ, Dept Thorac & Cardiovasc Surg, Sch Med, Seoul, South Korea | Lee, Jaehee/S-1697-2018; Choi, Sun Ha/HPD-7234-2023; Lee, Yoojin/AAB-9799-2022 | 8573181300; 57195437358; 49863712700; 37107028100; 56333658000; 55613917100; 57161223200; 57205472984; 57189600352; 55664096100; 7402410737; 57222170628; 57199723585; 57199022948; 55612130200; 56479781600; 13805476000; 35227126400; 7409873555; 23993782100; 35588946900; 58360293800 | shinyup@knu.ac.kr;jaeyong@knu.ac.kr; | ONCOLOGY | ONCOLOGY-BASEL | 0030-2414 | 1423-0232 | 99 | 5 | SCIE | ONCOLOGY | 2021 | 3.734 | 59.0 | 0 | 2025-07-30 | 2 | 1 | Activating transcription factor 3 binding site; Polymorphism; Expression quantitative trait loci; Non-small cell lung cancer; Prognosis | ADAPTIVE-RESPONSE GENE; ATF3; HAX-1; METASTASIS; IDENTIFICATION; EXPRESSION; PROTEIN | Activating Transcription Factor 3; Adaptor Proteins, Signal Transducing; Adenocarcinoma of Lung; Binding Sites; Biomarkers, Tumor; Carcinoma, Large Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Female; Follow-Up Studies; Genotype; Humans; Lung Neoplasms; Male; Middle Aged; NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases; Polymorphism, Single Nucleotide; Prognosis; Promoter Regions, Genetic; Survival Rate; activating transcription factor 3; cisplatin; histone H3; messenger RNA; paclitaxel; activating transcription factor 3; alcohol dehydrogenase; ATF3 protein, human; HAX1 protein, human; ME3 protein, human; signal transducing adaptor protein; tumor marker; A-549 cell line; adult; Article; ATF3 gene; binding site; cancer adjuvant therapy; cancer prognosis; cancer radiotherapy; cancer staging; clinical outcome; controlled study; disease free survival; enhancer region; expression quantitative trait locus; female; gene; gene activity; gene expression; genetic association; genetic variability; genotype; HAX1 gene; human; lung adenocarcinoma; lung large cell carcinoma; lung resection; major clinical study; male; ME3 gene; middle aged; non small cell lung cancer; postoperative period; promoter region; protein protein interaction; single nucleotide polymorphism; squamous cell lung carcinoma; follow up; genetics; large cell carcinoma; lung tumor; metabolism; non small cell lung cancer; pathology; prognosis; squamous cell carcinoma; survival rate | English | 2021 | 2021-04 | 10.1159/000514131 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | High-Performance Liquid Chromatography for Determining a Mixture of Nonsteroidal Anti-inflammatory Drugs | Nonsteroidal anti-inflammatory drugs (NSAIDs), which block the activity of cyclooxygenase (COX) isoenzymes and inhibit the synthesis of prostaglandin, have been used for pain relief. For the enhancement of the potency or the decrease of side-effects, NSAIDs are normally prescribed as a mixture with other chemical components including caffeine and proton pump inhibitor. Here, we developed a method to separate a mixture of three NSAIDs, such as aspirin, paracetamol, and naproxen, using reverse-phase high-performance liquid chromatography (RP-HPLC). An isocratic mobile phase consisting of acidic water and acetonitrile was selected to run at a low flow rate, such as 0.8 mL/min. The mixture of three NSAIDs was injected at a low volume into a C18 column having 150 mm in length and characterized using a UV detector at 230 nm. We identified three peaks in the chromatogram indicating three compounds. The elution time of the peaks was less than 10 min. The method proposed here can be used for identification of the combination of NSAIDs. | Hassan, Md Mynul; Nam, Sung-Wook | Kyungpook Natl Univ, Sch Med, Dept Mol Med, Daegu 41405, South Korea | ; Nam, Sung-Wook/V-5519-2019 | 57226694442; 16167127700 | nams@knu.ac.kr; | ELECTRONIC MATERIALS LETTERS | ELECTRON MATER LETT | 1738-8090 | 2093-6788 | 17 | 5 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY | 2021 | 3.151 | 59.0 | 0.38 | 2025-07-30 | 8 | 7 | High-performance liquid chromatography; Nonsteroidal anti-inflammatory drugs; Drug mixture; Separation; Short column | FIXED-DOSE COMBINATION; RP-HPLC METHOD; GASTROINTESTINAL TOXICITY; PARACETAMOL | Drug mixture; High-performance liquid chromatography; Nonsteroidal anti-inflammatory drugs; Separation; Short column | Chromatographic analysis; Drug interactions; Mixtures; Acidic water; Chemical component; Cyclooxygenases; Isocratic mobile phase; Non-steroidal anti-inflammatory drugs; Proton pump inhibitors; Reverse phase high performance liquid chromatography; Side effect; High performance liquid chromatography | English | 2021 | 2021-09 | 10.1007/s13391-021-00306-8 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Accuracy of automated identification of lateral cephalometric landmarks using cascade convolutional neural networks on lateral cephalograms from nationwide multi-centres | Objective To investigate the accuracy of automated identification of cephalometric landmarks using the cascade convolutional neural networks (CNN) on lateral cephalograms acquired from nationwide multi-centres. Settings and sample population A total of 3150 lateral cephalograms were acquired from 10 university hospitals in South Korea for training. Materials and Methods We evaluated the accuracy of the developed model with independent 100 lateral cephalograms as an external validation. Two orthodontists independently identified the anatomic landmarks of the test data set using the V-ceph software (version 8.0, Osstem, Seoul, Korea). The mean positions of the landmarks identified by two orthodontists were regarded as the gold standard. The performance of the CNN model was evaluated by calculating the mean absolute distance between the gold standard and the automatically detected positions. Factors associated with the detection accuracy for landmarks were analysed using the linear regression models. Results The mean inter-examiner difference was 1.31 +/- 1.13 mm. The overall automated detection error was 1.36 +/- 0.98 mm. The mean detection error for each landmark ranged between 0.46 +/- 0.37 mm (maxillary incisor crown tip) and 2.09 +/- 1.91 mm (distal root tip of the mandibular first molar). A significant difference in the detection accuracy among cephalograms was noted according to hospital (P = .011), sensor type (P < .01), and cephalography machine model (P < .01). Conclusion The automated cephalometric landmark detection model may aid in preliminary screening for patient diagnosis and mid-treatment assessment, independent of the type of the radiography machines tested. | Kim, Jaerong; Kim, Inhwan; Kim, Yoon-Ji; Kim, Minji; Cho, Jin-Hyoung; Hong, Mihee; Kang, Kyung-Hwa; Lim, Sung-Hoon; Kim, Su-Jung; Kim, Young Ho; Kim, Namkug; Sung, Sang-Jin; Baek, Seung-Hak | Univ Ulsan, Coll Med, Dept Orthodont, Asan Med Ctr, 88 Olymp Ro 43 Gil, Seoul 05505, South Korea; Univ Ulsan, Asan Med Inst Convergence Sci & Technol, Dept Convergence Med, Asan Med Ctr,Coll Med, Seoul, South Korea; Ewha Womans Univ, Coll Med, Dept Orthodont, Seoul, South Korea; Chonnam Natl Univ, Sch Dent, Dept Orthodont, Gwangju, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Orthodont, Daegu, South Korea; Wonkwang Univ, Sch Dent, Dept Orthodont, Iksan, South Korea; Chosun Univ, Dept Orthodont, Coll Dent, Gwangju, South Korea; Kyung Hee Univ, Sch Dent, Dept Orthodont, Seoul, South Korea; Ajou Univ, Sch Med, Inst Oral Hlth Sci, Dept Orthodont, Suwon, South Korea; Seoul Natl Univ, Dent Res Inst, Sch Dent, Dept Orthodont, 101 Daehak Ro, Seoul 03080, South Korea | Kim, Jung/L-9791-2019; kim, minji/GRX-9996-2022; Sung, Sang Jin/KBQ-4217-2024; Baek, Seung-Hak/NOE-8444-2025; KIM, SUHWAN/GSE-0120-2022 | 57389075600; 57222816092; 57221435554; 57201330607; 15764519700; 57190379016; 35285868600; 36793499100; 57039799500; 57207443980; 16550058300; 7202731963; 35090967400 | yn0331@ulsan.ac.kr;drwhite@unitel.co.kr; | ORTHODONTICS & CRANIOFACIAL RESEARCH | ORTHOD CRANIOFAC RES | 1601-6335 | 1601-6343 | 24 | SCIE | DENTISTRY, ORAL SURGERY & MEDICINE | 2021 | 2.563 | 59.2 | 5.41 | 2025-07-30 | 42 | 42 | anatomic landmarks; artificial intelligence; convolutional neural networks; deep learning | X-RAY IMAGES | Anatomic Landmarks; Cephalometry; Humans; Neural Networks, Computer; Radiography; Reproducibility of Results; anatomic landmark; cephalometry; human; radiography; reproducibility | English | 2021 | 2021-12 | 10.1111/ocr.12493 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Effect of tenofovir alafenamide vs. tenofovir disoproxil fumarate on hepatocellular carcinoma risk in chronic hepatitis B | It is unclear whether tenofovir disoproxil fumarate (TDF) or tenofovir alafenamide (TAF) is more effective for preventing hepatocellular carcinoma (HCC) development in patients with chronic hepatitis B (CHB). In this study, we compared the effectiveness of these two antiviral agents for preventing HCC. We included treatment-naive CHB patients undergoing antiviral therapy with TDF only (TDF group) or a TAF-based regimen (TAF group) at three academic teaching hospitals from 2012 to 2019. The TAF group included patients receiving TAF as first-line treatment and patients switching from TDF to TAF. Patients with decompensated cirrhosis or HCC at enrollment were excluded. Cumulative probabilities of HCC were assessed using Kaplan-Meier methodology. In total, 2,117 patients were included: 1,832 in the TDF group and 285 in the TAF group. The annual HCC incidence was not significantly different between TDF and TAF groups: 1.66 vs. 1.19 per 100 person-years [PY], respectively (multivariate analysis: adjusted hazard ratio [HR] 0.774 [reference: TDF group]; p = .438). Male, liver cirrhosis, hepatitis B e antigen negativity, Fibrosis-4 index>3.25 and low albumin were independently associated with a higher risk of HCC. Propensity score-matched and inverse probability of treatment weighting analyses yielded similar results: 1.56 vs. 1.19 per 100 PY, respectively (HR 1.175; p = .708) and 1.66 vs. 1.29 per 100 PY, respectively (HR 0.888; p = .446). The risk of HCC development was not significantly different between TDF and TAF groups of CHB patients. Further studies with a larger sample size and longer follow-up are required to validate our results. | Lee, Hye Won; Cho, Young Youn; Lee, Hyein; Lee, Jae Seung; Kim, Seung Up; Park, Jun Yong; Kim, Do Young; Ahn, Sang Hoon; Kim, Beom Kyung; Park, Soo Young | Yonsei Univ, Dept Internal Med, Coll Med, 50-1 Yonsei Ro, Seoul 03722, South Korea; Yonsei Univ, Inst Gastroenterol, Coll Med, Seoul, South Korea; Yonsei Univ Hlth Syst, Severance Hosp, Yonsel Liver Ctr, Seoul, South Korea; Chung Ang Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Kyungpook Natl Univ, Dept Internal Med, Sch Med, 130 Dongdeok Ro, Daegu 41944, South Korea | ; Kim, Sun Jung/AAM-7334-2020; Ahn, Sang Hoon/AFM-2603-2022; Park, Jun/H-7127-2019; Kim, Sun/L-4239-2013; Lee, Hye/D-9081-2016; Kim, Yoon/G-6633-2015; LEE, JAE SEUNG/KHT-9575-2024 | 57200110315; 55850994200; 57222812336; 57204060462; 54933821200; 47861376300; 56119929100; 7401989551; 35302925200; 57191674344 | beomkkim@yuhs.ac;psyoung0419@gmail.com; | JOURNAL OF VIRAL HEPATITIS | J VIRAL HEPATITIS | 1352-0504 | 1365-2893 | 28 | 11 | SCIE | GASTROENTEROLOGY & HEPATOLOGY;INFECTIOUS DISEASES;VIROLOGY | 2021 | 3.517 | 59.7 | 1.21 | 2025-07-30 | 17 | 20 | comparison; hepatocellular carcinoma; prevention; tenofovir alafenamide; tenofovir disoproxil fumarate | DOUBLE-BLIND; PHASE-3 | comparison; hepatocellular carcinoma; prevention; tenofovir alafenamide; tenofovir disoproxil fumarate | Alanine; Antiviral Agents; Carcinoma, Hepatocellular; Hepatitis B, Chronic; Humans; Liver Neoplasms; Male; Tenofovir; albumin; hepatitis B(e) antigen; tenofovir alafenamide; tenofovir disoproxil; alanine; antivirus agent; tenofovir; tenofovir alafenamide; adult; antiviral therapy; Article; cancer risk; chronic hepatitis B; drug effect; female; high risk population; human; incidence; liver cell carcinoma; major clinical study; male; methodology; middle aged; probability; teaching hospital; complication; liver cell carcinoma; liver tumor | English | 2021 | 2021-11 | 10.1111/jvh.13601 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | External validation of CAGE-B and SAGE-B scores for Asian chronic hepatitis B patients with well-controlled viremia by antivirals | CAGE-B and SAGE-B scores, consisting of age and fibrotic burden as cirrhosis and/or liver stiffness, were recently proposed to predict hepatocellular carcinoma (HCC) risk among Caucasian chronic hepatitis B (CHB) patients undergoing long-term antiviral therapy. We externally validated their predictive performances among an independent cohort from Asia, compared to other conventional prediction models. We consecutively recruited CHB patients with well-controlled viremia (serum HBV DNA = 11, the annual HCC incidences were 0.18, 1.34 and 6.03 per 100 person-years, respectively (all p = 11, those were 0.31, 1.49 and 8.96 per 100 person-years, respectively (all p < 0.001 between each pair). Hence, CAGE-B and SAGE-B scores showed acceptable predictive performances for Asian CHB patients undergoing antiviral therapy, with the higher performance by CAGE-B score. They show a trend towards better prognostic capability to predict HCC risk than previous models. | Ji, Jung Hyun; Park, Soo Young; Son, Won Jeong; Shin, Hye Jung; Lee, Hyein; Lee, Hye Won; Lee, Jae Seung; Kim, Seung Up; Park, Jun Yong; Kim, Do Young; Ahn, Sang Hoon; Kim, Beom Kyung | Yonsei Univ, Dept Internal Med, Coll Med, 50-1 Yonsei Ro, Seoul 03722, South Korea; Kyungpook Natl Univ, Dept Internal Med, Sch Med, Daegu, South Korea; Yonsei Univ, Dept Biomed Syst Informat, Biostat Collaborat Unit, Coll Med, Seoul, South Korea; Yonsei Univ Hlth Syst, Severance Hosp, Yonsei Liver Ctr, Seoul, South Korea; Yonsei Univ, Inst Gastroenterol, Coll Med, Seoul, South Korea | ; Kim, Yoon/G-6633-2015; Kim, Sun/L-4239-2013; LEE, JAE SEUNG/KHT-9575-2024; Lee, Hye/D-9081-2016; Park, Jun/H-7127-2019; SANG-HOON, AHN/AAV-2600-2020; Kim, Sun Jung/AAM-7334-2020; Ahn, Sang Hoon/AFM-2603-2022 | 57222814193; 57191674344; 57222811004; 57203549694; 57222812336; 57200110315; 57204060462; 54933821200; 47861376300; 56119929100; 7401989551; 35302925200 | beomkkim@yuhs.ac;lorry-lee@yuhs.ac;sikarue@yuhs.ac;ksukorea@yuhs.ac;DRPJY@yuhs.ac; | JOURNAL OF VIRAL HEPATITIS | J VIRAL HEPATITIS | 1352-0504 | 1365-2893 | 28 | 6 | SCIE | GASTROENTEROLOGY & HEPATOLOGY;INFECTIOUS DISEASES;VIROLOGY | 2021 | 3.517 | 59.7 | 0.43 | 2025-07-30 | 8 | 7 | CAGE‐ B; comparison; hepatocellular carcinoma; prediction; SAGE‐ B; validation | CAGE-B; comparison; hepatocellular carcinoma; prediction; SAGE-B; validation | Antiviral Agents; Carcinoma, Hepatocellular; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver Cirrhosis; Liver Neoplasms; Risk Factors; Viremia; antivirus agent; virus DNA; antivirus agent; adult; aged; antiviral therapy; Article; Asian; blood level; CAGE B score; CAMD score; cancer prognosis; cancer risk; chronic hepatitis B; cohort analysis; controlled study; disease course; disease risk assessment; female; follow up; human; human cell; incidence; liver cell carcinoma; major clinical study; male; middle aged; mPAGE B score; mREACH B score; nonhuman; PAGE B score; predictive validity; priority journal; retrospective study; risk assessment; SAGE B score; validation study; viremia; Hepatitis B virus; liver cell carcinoma; liver cirrhosis; liver tumor; risk factor; viremia | English | 2021 | 2021-06 | 10.1111/jvh.13506 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Validation of risk prediction scores for hepatocellular carcinoma in patients with chronic hepatitis B treated with entecavir or tenofovir | Several prediction scores for the early detection of hepatocellular carcinoma (HCC) are available. We validated the predictive accuracy of age, albumin, sex, liver cirrhosis (AASL), RESCUE-B, PAGE-B and modified PAGE-B (mPAGE-B) scores in chronic hepatitis B (CHB) patients treated with entecavir (ETV) or tenofovir disoproxil fumarate (TDF). Between 2007 and 2014, 3171 patients were recruited (1645, ETV; 1517, TDF). The predictive accuracy of each prediction score was assessed. The mean age of the study population (1977 men; 1194 women) was 48.8 years. Liver cirrhosis was present in 1040 (32.8%) patients. During follow-up (median, 58.2 months), 280 (8.8%) patients developed HCC; these patients were significantly older; more likely to be male; had significantly higher proportions of liver cirrhosis, hypertension and diabetes; and had significantly higher values for the four risk scores than those who did not develop HCC (allP < .05). Older age (hazard ratio [HR] = 1.048), male sex (HR = 2.142), liver cirrhosis (HR = 3.144) and prolonged prothrombin time (HR = 2.589) were independently associated with an increased risk of HCC (allP < .05), whereas a higher platelet count (HR = 0.996) was independently associated with a decreased risk of HCC (P < .05). The predictive accuracy of AASL score was the highest for 3- and 5-year HCC predictions (areas under the curve [AUCs] = 0.818 and 0.816, respectively), followed by RESCUE-B, PAGE-B and mPAGE-B scores (AUC = 0.780-0.815 and 0.769-0.814, respectively). In conclusion, four HCC prediction scores were assessed in Korean CHB patients treated with ETV or TDF. The AASL score showed the highest predictive accuracy. | Chang, Jin Won; Lee, Jae Seung; Lee, Hye Won; Kim, Beom Kyung; Park, Jun Yong; Kim, Do Young; Ahn, Sang Hoon; Seo, Yeon Seok; Lee, Han Ah; Kim, Mi Na; Lee, Yu Rim; Hwang, Seong Gyu; Rim, Kyu Sung; Um, Soon Ho; Tak, Won Young; Kweon, Young Oh; Park, Soo Young; Kim, Seung Up | Yonsei Univ, Dept Internal Med, Coll Med, 50-1 Yonsei Ro, Seoul 120752, South Korea; Yonsei Univ, Inst Gastroenterol, Coll Med, Seoul, South Korea; Severance Hosp, Yonsei Liver Ctr, Seoul, South Korea; Korea Univ, Dept Internal Med, Coll Med, Seoul, South Korea; CHA Univ, CHA Bundang Med Ctr, Dept Internal Med, Seongnam, South Korea; Kyungpook Natl Univ Hosp, Dept Internal Med, Daegu, South Korea | Ahn, Sang Hoon/AFM-2603-2022; Kim, Young/T-8521-2019; SANG-HOON, AHN/AAV-2600-2020; Kim, Eun Young/JCE-3602-2023; Lee, Hye/D-9081-2016; Kim, Nayoung/J-5387-2012; Kim, Dong/F-4608-2014; LEE, JAE SEUNG/KHT-9575-2024; Lee, YuRim/ITU-1407-2023; Park, Jun/H-7127-2019; Kim, Sun/L-4239-2013; Kim, Jin Hyoung/AAE-8050-2019 | 57219319932; 57204060462; 57200110315; 35302925200; 47861376300; 56119929100; 7401989551; 35234912400; 57190980926; 57202910894; 57194094753; 7404626618; 7007082564; 7005044023; 7004074582; 7004694832; 57191674344; 54933821200 | KSUKOREA@yuhs.ac; | JOURNAL OF VIRAL HEPATITIS | J VIRAL HEPATITIS | 1352-0504 | 1365-2893 | 28 | 1 | SCIE | GASTROENTEROLOGY & HEPATOLOGY;INFECTIOUS DISEASES;VIROLOGY | 2021 | 3.517 | 59.7 | 0.57 | 2025-07-30 | 11 | 10 | CLINICAL-PRACTICE GUIDELINES; NATURAL-HISTORY; SCORING SYSTEM; MANAGEMENT; CIRRHOSIS; GENOTYPES; THERAPY | antiviral therapy; chronic hepatitis B; entecavir; hepatocellular carcinoma; risk prediction score; tenofovir disoproxil fumarate | Aged; Antiviral Agents; Carcinoma, Hepatocellular; Female; Guanine; Hepatitis B, Chronic; Humans; Infant, Newborn; Liver Neoplasms; Male; Retrospective Studies; Tenofovir; albumin; entecavir; tenofovir disoproxil; antivirus agent; entecavir; guanine; tenofovir; adult; age; Article; cancer risk; chronic hepatitis B; controlled study; diabetes mellitus; female; follow up; human; hypertension; liver cell carcinoma; liver cirrhosis; major clinical study; male; prediction; priority journal; prothrombin time; risk assessment; sex; validation study; aged; complication; liver cell carcinoma; liver tumor; newborn; retrospective study | English | 2021 | 2021-01 | 10.1111/jvh.13411 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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