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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | A sampling theorem by perturbing the zeros of a sine-type function | In this paper, we present a generalisation of the classical Shannon sampling theorem that allows for sampling sets that are perturbations of the set of zeros of a sine-type function. Such sampling sets may be non-equidistant and non-periodic. | Al-Hammali, Hussain; Faridani, Adel | Kyungpook Natl Univ, Coll Nat Sci, Dept Math, Daegu 41566, South Korea; Oregon State Univ, Dept Math, Corvallis, OR 97331 USA | 57211075123; 6602323523 | hussain@knu.ac.kr; | APPLICABLE ANALYSIS | APPL ANAL | 0003-6811 | 1563-504X | 100 | 14 | SCIE | MATHEMATICS, APPLIED | 2021 | 1.278 | 56.0 | 0.15 | 2025-07-30 | 1 | 1 | Shannon sampling; Paley-Wiener spaces; zeros of a sine-type function; Riesz basis; non-equidistant sampling | non-equidistant sampling; Paley–Wiener spaces; Riesz basis; Shannon sampling; zeros of a sine-type function | English | 2021 | 2021-10-26 | 10.1080/00036811.2020.1712365 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Pre-Admission CHADS2 and CHA2DS2-VASc Scores on Early Neurological Worsening | Background: Stroke risk scores (CHADS(2) and CHA(2)DS(2)-VASc) not only predict the risk of stroke in atrial fibrillation (AF) patients, but have also been associated with prognosis after stroke. Objective: The aim of this study was to evaluate the relationship between stroke risk scores and early neurological deterioration (END) in ischemic stroke patients with AF. Methods: We included consecutive ischemic stroke patients with AF admitted between January 2013 and December 2015. CHADS(2) and CHA(2)DS(2)-VASc scores were calculated using the established scoring system. END was defined as an increase >= 2 on the total National Institutes of Health Stroke Scale (NIHSS) score or >= 1 on the motor NIHSS score within the first 72 h of admission. Results: A total of 2,099 ischemic stroke patients with AF were included. In multivariable analysis, CHA(2)DS(2)-VASc score (adjusted odds ratio [aOR] = 1.17, 95% confidence interval [CI] = 1.04-1.31) was significantly associated with END after adjusting for confounders. Initial NIHSS score, use of anticoagulants, and intracranial atherosclerosis (ICAS) were also found to be closely associated with END, independent of the CHA(2)DS(2)-VASc score. Multivariable analysis stratified by the presence of ICAS demonstrated that both CHA(2)DS(2)-VASc (aOR = 1.20, 95% CI = 1.04-1.38) and CHADS(2) scores (aOR = 1.24, 95% CI = 1.01-1.52) were closely related to END in only patients with ICAS. In patients without ICAS, neither of the risk scores were associated with END. Conclusions: High CHA(2)DS(2)-VASc score was associated with END in ischemic stroke patients with AF. This close relationship is more pronounced in patients with ICAS. | Nam, Ki-Woong; Kim, Chi Kyung; Yu, Sungwook; Chung, Jong-Won; Bang, Oh Young; Kim, Gyeong-Moon; Jung, Jin-Man; Song, Tae-Jin; Kim, Yong-Jae; Kim, Bum Joon; Heo, Sung Hyuk; Park, Kwang-Yeol; Kim, Jeong-Min; Park, Jong-Ho; Choi, Jay Chol; Park, Man-Seok; Kim, Joon-Tae; Choi, Kang-Ho; Hwang, Yang Ha; Oh, Kyungmi; Seo, Woo-Keun | Seoul Natl Univ, Dept Neurol, Coll Med, Seoul, South Korea; Korea Univ, Coll Med, Dept Neurol, Guro Hosp, Seoul, South Korea; Korea Univ, Coll Med, Dept Neurol, Anam Hosp, Seoul, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Neurol, Sch Med, Seoul, South Korea; Korea Univ, Coll Med, Dept Neurol, Ansan Hosp, Ansan, South Korea; Ewha Womans Univ, Sch Med, Dept Neurol, Seoul, South Korea; Catholic Univ Korea, Dept Neurol, Seoul, South Korea; Kyung Hee Univ, Dept Neurol, Coll Med, Seoul, South Korea; Chung Ang Univ, Chung Ang Univ Hosp, Dept Neurol, Coll Med, Seoul, South Korea; Hanyang Univ, Myongji Hosp, Dept Neurol, Coll Med, Seoul, South Korea; Jeju Natl Univ, Dept Neurol, Jeju, South Korea; Chonnam Natl Univ Hosp, Dept Neurol, Chungnam, South Korea; Chonnam Natl Univ, Dept Neurol, Hwasun Hosp, Hwasun, South Korea; Kyungpook Natl Univ Hosp, Dept Neurol, Daegu, South Korea; Sungkyunkwan Univ, SHAIST, Dept Digital Hlth, Seoul, South Korea | Kim, Yong-Jae/JQW-5758-2023; Kim, Jae/W-6208-2019; Jung, Jin-Man/LJL-8037-2024; choi, jo/O-5940-2014; Kim, Chi/AAR-9819-2020; Kim, Jeong-Min/ABH-2469-2021; Choi, Kangho/HKV-1503-2023; Heo, Sung/P-3529-2019; HWANG, Yang-Ha/F-3068-2013; Kim, Bum Joon/S-2156-2017 | 57189377536; 56701057800; 56144716300; 55553751200; 7006620221; 35237139600; 15755814800; 55507164200; 55865497600; 57214661365; 18835720200; 36060099300; 7601375827; 55716977200; 7501392645; 7404490852; 23667663000; 36491173100; 7402311308; 16048029600; 22981667600 | ckkim7@korea.ac.kr;mcastenosis@gmail.com; | CEREBROVASCULAR DISEASES | CEREBROVASC DIS | 1015-9770 | 1421-9786 | 50 | 3 | SCIE | CLINICAL NEUROLOGY;PERIPHERAL VASCULAR DISEASE | 2021 | 3.104 | 56.0 | 0.09 | 2025-07-30 | 2 | 1 | Ischemic stroke; Atrial fibrillation; Risk scores; Prognosis; Cerebral atherosclerosis | ISCHEMIC-STROKE PATIENTS; ATRIAL-FIBRILLATION; R(2)CHADS(2) SCORES; HEART-FAILURE; RISK-FACTORS; PREVENTION; PREVALENCE; PREDICTION; OUTCOMES; DETERIORATION | Atrial fibrillation; Cerebral atherosclerosis; Ischemic stroke; Prognosis; Risk scores | Aged; Aged, 80 and over; Atrial Fibrillation; Decision Support Techniques; Disability Evaluation; Disease Progression; Emergency Medical Services; Female; Humans; Intracranial Arteriosclerosis; Ischemic Stroke; Male; Middle Aged; Predictive Value of Tests; Prognosis; Registries; Republic of Korea; Retrospective Studies; Risk Assessment; Risk Factors; alteplase; anticoagulant agent; adult; Article; atrial fibrillation; brain atherosclerosis; brain ischemia; cardioembolic stroke; cerebrovascular accident; CHA2DS2-VASc score; CHADS2 score; cohort analysis; controlled study; coronary artery disease; diabetes mellitus; dual antiplatelet therapy; female; follow up; human; hypertension; major clinical study; male; middle cerebral artery occlusion; National Institutes of Health Stroke Scale; neurologic disease; nuclear magnetic resonance imaging; observational study; prevalence; prospective study; Rankin scale; receiver operating characteristic; retrospective study; risk factor; scoring system; sensitivity and specificity; stroke patient; subarachnoid hemorrhage; transient ischemic attack; aged; atrial fibrillation; brain atherosclerosis; brain ischemia; clinical trial; complication; decision support system; disability; disease exacerbation; emergency health service; middle aged; multicenter study; pathophysiology; predictive value; prognosis; register; risk assessment; South Korea; very elderly | English | 2021 | 2021-05 | 10.1159/000513396 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Cathepsin A regulates pluripotency, proliferation and differentiation in mouse embryonic stem cells | Mouse embryonic stem cells (mESCs) are pluripotent cells that possess the ability to self-renew and differentiate into three germ layers. Owing to these characteristics, mESCs act as important models for stem cell research and are being used in many clinical applications. Among the many cathepsins, cathepsin A (Ctsa), a serine protease, affects the function and properties of stem cells. However, studies on the role of Ctsa in stem cells are limited. Here, we observed a significant increase in Ctsa expression during mESC differentiation at protein levels. Furthermore, we established Ctsa knockdown mESCs. Ctsa knockdown led to Erk1/2 phosphorylation, which in turn inhibited the pluripotency of mESCs and induced G2/M cell cycle arrest to inhibit mESC proliferation. The knockdown also induced abnormal differentiation in mESCs and aberrant expression of differentiation markers. Furthermore, we identified inhibition of teratoma formation in nude mice. Our results suggested that Ctsa affects mESC pluripotency, proliferation, cell cycle and differentiation, and highlighted the potential of Ctsa to act as a core factor that can regulate various mESC properties. Significance of the study Our results indicate that cathepsin A (Ctsa) affects the properties of mESCs. Inhibition of Ctsa resulted in a decrease in the pluripotency of mouse embryonic stem cells (mESCs). Further, Ctsa suppression resulted in decreased proliferation via cell cycle arrest. Moreover, Ctsa inhibition reduced differentiation abilities and formation of teratoma in mESCs. Our results demonstrated that Ctsa is an important factor controlling mESC abilities. | Park, Song; Huang, Hai; Kwon, Wookbong; Kim, Hee-Yeon; Park, Jin-Kyu; Han, Jee Eun; Cho, Gil-Jae; Han, Se-Hyeon; Sung, Yonghun; Ryoo, Zae Young; Kim, Myoung Ok; Choi, Seong-Kyoon | DGIST, Dept Brain & Cognit Sci, Daegu, South Korea; DGIST, Core Prot Resources Ctr, Daegu, South Korea; Kyungpook Natl Univ, Sch Anim BT Sci, 2559 Gyeongsang Daero, Sangju Si 37224, Gyeongsangbuk D, South Korea; DGIST, Div Biotechnol, Daegu, South Korea; Kyungpook Natl Univ, Coll Vet Med, Daegu, South Korea; Hanyang Univ, Sch Media Commun, Seoul, South Korea; Daegu Gyeongbuk Med Innovat Fdn, Lab Anim Ctr, Daegu, South Korea; Kyungpook Natl Univ, Sch Life Sci, Plus KNU Creat Biores Grp BK21, Daegu, South Korea | RYOO, ZAEYOUNG/AAQ-1573-2020 | 57139047900; 57215021952; 57139843600; 58368914700; 35213723500; 57214671240; 7201438083; 57210915063; 58903739800; 16937104900; 8934745900; 55505432500 | ok4325@knu.ac.kr;cskbest@dgist.ac.kr; | CELL BIOCHEMISTRY AND FUNCTION | CELL BIOCHEM FUNCT | 0263-6484 | 1099-0844 | 39 | 1 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CELL BIOLOGY | 2021 | 3.963 | 56.1 | 0.56 | 2025-07-30 | 8 | 8 | Cathepsin A; cell cycle; differentiation; pluripotency; proliferation | DOWN-REGULATION; SELF-RENEWAL | Cathepsin A; cell cycle; differentiation; pluripotency; proliferation | Animals; Cathepsin A; Cell Differentiation; Cell Line; Cell Proliferation; G2 Phase Cell Cycle Checkpoints; Gene Knockdown Techniques; M Phase Cell Cycle Checkpoints; MAP Kinase Signaling System; Mice; Mouse Embryonic Stem Cells; alpha fetoprotein; carboxypeptidase C; microtubule associated protein 2; mitogen activated protein kinase 1; mitogen activated protein kinase 3; nestin; short hairpin RNA; synaptophysin; carboxypeptidase C; CTSA protein, mouse; animal cell; animal experiment; apoptosis; apoptosis assay; Article; carcinogenesis; cell differentiation; cell proliferation; enzyme phosphorylation; flow cytometry; G2 phase cell cycle checkpoint; gene knockdown; in vitro study; in vivo study; male; marker gene; microscopy; mouse; mouse embryonic stem cell; nonhuman; pluripotent stem cell; priority journal; protein expression; real time polymerase chain reaction; stem cell self-renewal; teratoma; animal; cell line; cytology; enzymology; genetics; M phase cell cycle checkpoint; MAPK signaling; metabolism; mouse embryonic stem cell | English | 2021 | 2021-01 | 10.1002/cbf.3554 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Co-dispersion and co-deposition of clay/MoS2 and its application on epoxy nanocomposites | In recent years, polymer nanocomposites based on 2D materials have aroused widespread research interest. MoS2 exhibits many excellent properties due to its unique structure, such as mechanical properties, thermal stability, and fire resistance properties. It has great potential as a polymer reinforcement material and functional nanofiller. However, it is well known that the exfoliated MoS2 layers have a tendency to aggregate during mixing with polymers, which results in the polymer performance cannot be effectively improved. In this work, clay was introduced into molybdenum disulfide (MoS2) to improve the dispersion of exfoliated MoS2. After co-deposition, two different layered fillers co-stacked to form a novel clay/MoS2 composite. The presence of clay in the MoS2 slurry prevented aggregation of the individual clay and MoS2 layers. The resulting clay/MoS2 composite was further used as fillers to form epoxy/clay/MoS2 nanocomposites. The effects of clay, MoS2 and clay/MoS2 mixture on the properties of epoxy nanocomposites were investigated and compared. It was found that combining clay and MoS2 allows the enhancement of tensile strength and tensile modulus. Additionally, due to the well co-dispersion of clay and MoS2, the thermal stability and mechanical properties of epoxy/clay/MoS2 nanocomposites are higher than those of epoxy/clay and epoxy/MoS2 nanocomposites. Therefore, this work provides a facile way to produce high-performance epoxy nanocomposites. | Xie, Han-Lin; Han, Wei; Yan, Xin; Ni, Bao-Jian; Chen, Bin; Zhang, He-Xin; Yoon, Keun-Byoung | Anhui Univ Technol, Sch Chem & Chem Engn, Maanshan 243032, Peoples R China; Shenyang Univ Chem Technol, Sch Mat Sci & Engn, Shenyang 110870, Peoples R China; Kyungpook Natl Univ, Dept Polymer Sci & Engn, Daegu 702701, South Korea | Hexin, Zhang/ACI-3911-2022 | 57222028253; 57222028137; 57222030771; 57202385914; 57037298700; 25633288200; 7401607550 | 1871383636@qq.com;13080896558@163.com;hxzhang@ahut.edu.cn;kbyoon@knu.ac.kr; | IRANIAN POLYMER JOURNAL | IRAN POLYM J | 1026-1265 | 1735-5265 | 30 | 8 | SCIE | POLYMER SCIENCE | 2021 | 2.485 | 56.1 | 0 | 2025-07-30 | 0 | 0 | Epoxy; Clay; MoS2; Nanocomposite; Mechanical properties | REDUCING FIRE HAZARDS; ZIEGLER-NATTA CATALYST; MECHANICAL-PROPERTIES; MOLYBDENUM-DISULFIDE; MOS2 NANOSHEETS; FABRICATION; GRAPHENE; REINFORCEMENT; COMPOSITES; STIFFNESS | Clay; Epoxy; Mechanical properties; MoS<sub>2</sub>; Nanocomposite | Aggregates; Deposition; Dispersions; Fillers; Fire resistance; Layered semiconductors; Molybdenum compounds; Nanocomposites; Polymers; Tensile strength; Thermodynamic stability; Epoxy nanocomposites; Fire resistance properties; ITS applications; Layered fillers; Molybdenum disulfide; Polymer nanocomposite; Polymer reinforcements; Research interests; Sulfur compounds | English | 2021 | 2021-08 | 10.1007/s13726-021-00929-6 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Modeling of mineral elements uptake and localization in cabbage inflorescence (Brassica oleracea var. capitata) grown on sugar mill pressmud-amended soils | Sugar mill pressmud is highly considered and used as a supplement to improve soil fertility and crop yield, especially in India. This study investigated the growth and yield performance of cultivated cabbage (Brassica oleracea var. capitata) on sugar mill pressmud amended soil. Pot experiments were performed using various pressmud amendment rates (0, 50, 100, and 150 g/kg soil) to study the fertilization impact on cabbage inflorescence yield (g) and size (diameter: cm). Moreover, mineral element (Cd, Cr, Cu, Fe, Mn, and Zn) accumulation in the cabbage inflorescence was also studied using a modified polynomial non-linear model. Results showed that the sugar mill pressmud had significantly (p Mn > Zn > Cu > Cr > Zn. Furthermore, the developed modified polynomial quadratic model precisely predicted the total mineral element uptake (mg dwt.) by cabbage inflorescence. The models had good fitness as described by the coefficient of determination (R-2 > 0.992) values. This study suggested that sugar mill pressmud was a promising resource for cabbage cultivation, and the developed models were helpful in the precise prediction of mineral elements accumulated by its inflorescence. | Eid, Ebrahem M.; Kumar, Pankaj; Adelodun, Bashir; Choi, Kyung Sook; Singh, Jogendra; Kumari, Sonika; Kumar, Vinod | King Khalid Univ, Biol Dept, Coll Sci, Abha 61321, Saudi Arabia; Kafrelsheikh Univ, Bot Dept, Fac Sci, Kafr Al Sheikh 33516, Egypt; Gurukula Kangri Deemed Univ, Dept Zool & Environm Sci, Agroecol & Pollut Res Lab, Haridwar 249404, Uttarakhand, India; Kyungpook Natl Univ, Dept Agr Civil Engn, Daegu, South Korea; Univ Ilorin, Dept Agr & Biosyst Engn, PMB 1515, Ilorin, Nigeria | Kumar, Dr. Vinod/K-9971-2016; Adelodun, Bashir/O-2941-2018; Kumar, Pankaj/AAF-2231-2019; Kumar, Vinod/V-8332-2019; Eid, Ebrahem/O-2723-2013 | 35794350700; 57281192700; 57193774482; 54392662900; 57193220273; 57226814250; 57200152850 | drvksorwal@gkv.ac.in; | ENVIRONMENTAL MONITORING AND ASSESSMENT | ENVIRON MONIT ASSESS | 0167-6369 | 1573-2959 | 193 | 9 | SCIE | ENVIRONMENTAL SCIENCES | 2021 | 3.307 | 56.1 | 0.41 | 2025-07-30 | 8 | 7 | Industrial sludge; Prediction models; Soil pollution; Sustainable agriculture; Vegetable contamination | Industrial sludge; Prediction models; Soil pollution; Sustainable agriculture; Vegetable contamination | Brassica; Environmental Monitoring; Inflorescence; Metals, Heavy; Minerals; Soil; Soil Pollutants; Sugars; Brassica oleracea var. capitata; Soils; Sugar factories; Value engineering; Vegetation; cadmium; chlorophyll; chromium; copper; element; fertilizer; glutathione transferase; glyphosate; iron; manganese; mineral; nickel; organic carbon; phytohormone; sugar; zinc; carbohydrate; heavy metal; mineral; Brassica oleracea; Coefficient of determination; Developed model; Growth and yield; Mineral element; Non-linear model; Nutrient elements; Quadratic modeling; alternative agriculture; crop yield; growth response; leafy vegetable; mineral; numerical model; prediction; sludge; soil amendment; soil pollution; agricultural worker; Article; atomic absorption spectrometry; aubergine; barley; bioaccumulation; biomass production; cabbage; controlled study; dry weight; fertility; fertilization; gene location; germination; grain yield; Helianthus annuus; industrial sludge; inflorescence; infrared spectroscopy; leaf area; limit of detection; mathematical model; nonhuman; nutrient; plant growth; plant height; plant leaf; prediction; response surface method; seed yield; soil fertility; soil pollution; soil quality; spectroscopy; sugar mill pressmud amended soil; sustainable agriculture; Brassica; chemistry; environmental monitoring; inflorescence; soil; soil pollutant; Minerals | English | 2021 | 2021-09 | 10.1007/s10661-021-09381-8 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | No evidence for global decrease in CO2 concentration during the first wave of COVID-19 pandemic | Numerous studies have reported that CO2 emissions have decreased because of global lockdown during the first wave of the COVID-19 pandemic. However, previous estimates of the global CO2 concentration before and after the outbreak of the COVID-19 pandemic are limited because they are based on energy consumption statistics or local specific in-situ observations. The aim of the study was to explore objective evidence for various previous studies that have claimed the global CO2 concentration decreased during the first wave of the COVID-19 pandemic. There are two ways to measure the global CO2 concentration: from the top-down using satellites and the bottom-up using ground stations. We implemented the time-series analysis by comparing the before and after the inflection point (first wave of COVID-19) with the long-term CO2 concentration data obtained from World Meteorological Organization Global Atmosphere Watch (WMO GAW) and Greenhouse Gases Observing Satellite (GOSAT). Measurements from the GOSAT and GAW global monitoring stations show that the CO2 concentrations in Europe, China, and the USA have continuously risen in March and April 2020 compared with the same months in 2019. These data confirm that the global lockdown during the first wave of the COVID-19 pandemic did not change the vertical CO2 profile at the global level from the ground surface to the upper layer of the atmosphere. The results of this study provide an important foundation for the international community to explore policy directions to mitigate climate change in the upcoming post-COVID-19 period. | Hwang, YoungSeok; Roh, Jong Wook; Suh, Dongjun; Otto, Marc-Oliver; Schlueter, Stephan; Choudhury, Tanupriya; Huh, Jeung-Soo; Um, Jung-Sup | Kyungpook Natl Univ, Dept Climate Change, 80 Daehak Ro, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Nano & Mat Sci & Engn, 2559 Gyeongsang Daero, Sangju Si 37224, Gyeongsangbuk D, South Korea; Kyungpook Natl Univ, Dept Convergence & Fus Syst Engn, 2559 Gyeongsang Daero, Sangju Si 37224, Gyeongsangbuk D, South Korea; Ulm Univ Appl Sci, Dept Math Nat & Econ Sci, Prittwitzstr 10, D-89075 Ulm, Germany; Univ Petr & Energy Studies, Sch Comp Sci, Dept Informat, Dehra Dun 248007, Uttarakhand, India; Kyungpook Natl Univ, Dept Geog, 80 Daehak Ro, Daegu 41566, South Korea | Um, Jung-Sup/F-5351-2018; Choudhury, Tanupriya/AAB-8947-2020 | 57218585482; 25638796100; 36613529600; 57217105369; 55258366500; 57193140084; 7102258915; 35173565000 | jsaeom@knu.ac.kr; | ENVIRONMENTAL MONITORING AND ASSESSMENT | ENVIRON MONIT ASSESS | 0167-6369 | 1573-2959 | 193 | 11 | SCIE | ENVIRONMENTAL SCIENCES | 2021 | 3.307 | 56.1 | 0.18 | 2025-07-30 | 2 | 3 | COVID-19; Carbon budget; CO2 profile; Corona; Global Atmosphere Watch (GAW); GOSAT (Greenhouse Gases Observing Satellite); World Meteorological Organization (WMO) | ADMINISTRATIVE REGIONS; OCO-2 XCO2; GOSAT; NORTHERN; CYCLE; LAND | Corona; COVID-19; Carbon budget; CO<sub>2</sub> profile; Global Atmosphere Watch (GAW); GOSAT (Greenhouse Gases Observing Satellite); World Meteorological Organization (WMO) | Carbon Dioxide; Communicable Disease Control; COVID-19; Environmental Monitoring; Humans; Pandemics; SARS-CoV-2; China; Europe; United States; Satellites; Budget control; Carbon; Climate change; Energy utilization; Greenhouse gases; Locks (fasteners); Satellites; Watches; carbon dioxide; carbon dioxide; Carbon budget;; Carbon budgets; CO2 profile; Corona; COVID-19;; Global atmosphere watch; Global atmosphere watches; Greenhouse gas observing satellite; Greenhouse gas observing satellites; World meteorological organization; World meteorological organizations; carbon dioxide; carbon emission; climate change; concentration (composition); COVID-19; disease spread; epidemic; GOSAT; Article; carbon footprint; China; climate change; concentration (parameter); coronavirus disease 2019; energy consumption; Europe; intermethod comparison; national lockdown; pandemic; pollution monitoring; satellite imagery; time series analysis; United States; communicable disease control; environmental monitoring; human; pandemic; Carbon dioxide | English | 2021 | 2021-11 | 10.1007/s10661-021-09541-w | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Effects of Exposure Parameters and Voxel Size for Cone-Beam Computed Tomography on the Image Matching Accuracy with an Optical Dental Scan Image: An In Vitro Study | This study is aimed at assessing the effects of exposure parameters and voxel size for cone-beam computed tomography (CBCT) on the image matching accuracy with an optical dental scan image. CBCT and optical scan images of a dry human mandible were obtained. Different CBCT settings were used: tube voltage, 60, 80, and 100 kVp; tube current, 6 and 8 mA; and voxel size, 100, 200, and 300 mu m. Image matching between the CBCT and optical scan images was performed using implant planning software by dental professionals (n=18). The image matching accuracy in each combination of CBCT settings was evaluated by assessing the linear discrepancy between the three-dimensionally reconstructed radiological image and the registered optical scan image using an image analysis software program. The Kruskal-Wallis test and a post hoc Mann-Whitney U test with Bonferroni correction were used to compare the accuracy of image registration between the groups (alpha=0.05). Overall, the image matching accuracy was not significantly different between tube voltage and current settings; however, significantly higher image registration errors were found at the combination of 100 kVp tube voltage/8 mA tube current (F=8.44, P<0.001). Changes in voxel sizes did not significantly interfere with the image registration results. No interaction was found among voltage, current, and voxel size in terms of image registration accuracy (F=2.022, P=0.091). Different exposure parameter settings in tube voltage and tube current did not significantly influence the image matching accuracy between CBCT and optical dental scan images; however, a high radiation dose could be inappropriate. The image matching accuracy was not significantly affected by changing the voxel sizes of CBCT. | Mai, Hang-Nga; Lee, Du-Hyeong | Kyungpook Natl Univ, Inst Translat Res Dent, 2177 Dalgubeoldae Ro, Daegu 41940, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Prosthodont, 2177 Dalgubeoldae Ro, Daegu 41940, South Korea | ; Mai, Hang-Nga/Q-9865-2018 | 56964780900; 35770948000 | mai.hang.nga1403@gmail.com;deweylee@knu.ac.kr; | BIOMED RESEARCH INTERNATIONAL | BIOMED RES INT | 2314-6133 | 2314-6141 | 2021 | SCIE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL | 2021 | 3.246 | 56.3 | 0.27 | 2025-07-30 | 6 | 6 | DIAGNOSTIC ABILITY; ROOT FRACTURES; RECONSTRUCTIONS; OPTIMIZATION; DENTISTRY; QUALITY; CT | Algorithms; Cone-Beam Computed Tomography; Humans; Image Processing, Computer-Assisted; Imaging, Three-Dimensional; In Vitro Techniques; Mandible; Optical Imaging; Radiography, Dental; Reproducibility of Results; Skull; Software; Article; cone beam computed tomography; controlled study; diagnostic accuracy; diagnostic test accuracy study; digital imaging and communications in medicine; human; image analysis; image reconstruction; image registration; imaging; in vitro study; Kruskal Wallis test; mandible; optical dental scan; radiation dose; algorithm; cone beam computed tomography; devices; diagnostic imaging; fluorescence imaging; image processing; pathology; procedures; reproducibility; skull; software; three-dimensional imaging; tooth radiography | English | 2021 | 2021-06-11 | 10.1155/2021/6971828 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | IFN-γ Licensing Does Not Enhance the Reduced Immunomodulatory Potential and Migratory Ability of Differentiation-Induced Porcine Bone Marrow-Derived Mesenchymal Stem Cells in an In Vitro Xenogeneic Application | IFN-gamma licensing to mesenchymal stem cells (MSCs) is applied to enhance the therapeutic potential of MSCs. However, although the features of MSCs are affected by several stimuli, little information is available on changes to the therapeutic potential of IFN-gamma-licensed differentiated MSCs during xenogeneic applications. Therefore, the present study is aimed at clarifying the effects of adipogenic/osteogenic differentiation and IFN-gamma licensing on the in vitro immunomodulatory and migratory properties of porcine bone marrow-derived MSCs in xenogeneic applications using human peripheral blood mononuclear cells (PBMCs). IFN-gamma licensing in differentiated MSCs lowered lineage-specific gene expression but did not affect MSC-specific cell surface molecules. Although indoleamine 2,3 deoxygenase (IDO) activity and expression were increased after IFN-gamma licensing in undifferentiated MSCs, they were reduced after differentiation. IFN-gamma licensing to differentiated MSCs elevated the reduced IDO expression in differentiated MSCs; however, the increase was not sufficient to reach to the level achieved by undifferentiated MSCs. During a mixed lymphocyte reaction with quantification of TNF-alpha concentration, proliferation and activation of xenogeneic PBMCs were suppressed by undifferentiated MSCs but inhibited to a lesser extent by differentiated MSCs. IFN-gamma licensing increasingly suppressed proliferation of PBMCs in undifferentiated MSCs but it was incapable of elevating the reduced immunosuppressive ability of differentiated MSCs. Migratory ability through a scratch assay and gene expression study was reduced in differentiated MSCs than their undifferentiated counterparts; IFN-gamma licensing was unable to enhance the reduced migratory ability in differentiated MSCs. Similar results were found in a Transwell system with differentiated MSCs in the upper chamber toward xenogeneic PBMCs in the lower chamber, despite IFN-gamma licensing increased the migratory ability of undifferentiated MSCs. Overall, IFN-gamma licensing did not enhance the reduced immunomodulatory and migratory properties of differentiated MSCs in a xenogeneic application. This study provides a better understanding of the ways in which MSC therapy can be applied. | Lee, Hyeon-Jeong; Kim, Hwan-Deuk; Jo, Chan-Hee; Bok, Eun-Yeong; Kim, Saet-Byul; Lee, Sung-Lim; Jang, Min; Bae, Seul-Gi; Yun, Sung-Ho; Kim, Seung-Joon; Rho, Gyu-Jin; Lee, Won-Jae | Gyeongsang Natl Univ, Coll Vet Med, Jinju 52828, South Korea; Kyungpook Natl Univ, Coll Vet Med, Daegu 41566, South Korea; Daegu Metropolitan City Inst Hlth & Environm, Dept Vet Res, Daegu 42183, South Korea | bok, eun yeong/MYS-4388-2025; Kim, Saet-Byul/AAK-7920-2021 | 57202973938; 57219801684; 57221808828; 57221645701; 57221645272; 16678898100; 55341507600; 55418865900; 57201366734; 55718678200; 6603725057; 57205486455 | iamcyshd@knu.ac.kr; | BIOMED RESEARCH INTERNATIONAL | BIOMED RES INT | 2314-6133 | 2314-6141 | 2021 | SCIE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL | 2021 | 3.246 | 56.3 | 0.14 | 2025-07-30 | 2 | 2 | CHONDROGENIC DIFFERENTIATION; ADIPOGENIC DIFFERENTIATION; IMMUNOSUPPRESSIVE PROPERTIES; IMMUNOLOGICAL-PROPERTIES; STROMAL CELLS; EXPRESSION; CAPACITY; MARKERS; ALTERS | Animals; Bone Marrow; Bone Marrow Cells; Cell Differentiation; Cell Movement; Cell Proliferation; Cells, Cultured; Coculture Techniques; Cytokines; Heterografts; Humans; Immunomodulation; Interferon-gamma; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Osteogenesis; Swine; Tumor Necrosis Factor-alpha; gamma interferon; indoleamine 2,3 dioxygenase; tumor necrosis factor; cytokine; gamma interferon; tumor necrosis factor; adipogenesis; animal cell; Article; bone development; bone marrow mesenchymal stem cell; cell activation; cell differentiation; cell migration; cell proliferation; cell surface; controlled study; enzyme activity; female; gene expression; human; human cell; immunomodulation; in vitro study; mixed lymphocyte reaction; nonhuman; peripheral blood mononuclear cell; pig; protein expression; transwell assay; wound healing assay; xenograft; animal; bone marrow; bone marrow cell; cell culture; cell differentiation; cell motion; coculture; drug effect; immunomodulation; mesenchymal stem cell; mesenchymal stem cell transplantation; metabolism; physiology; procedures | English | 2021 | 2021-09-06 | 10.1155/2021/4604856 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Renal Protective Effect of Beluga Lentil Pretreatment for Ischemia-Reperfusion Injury | Background and Aim. Ischemia/reperfusion (I/R) injury, caused by acute kidney damage, causes histopathological alterations, tubule cell apoptosis, inflammation, oxidation, and the loss of renal function. We evaluated the protective effects against I/R injury of beluga lentil pretreatment. Materials and Methods. Mice were divided into four groups: normal, untreated, low- (2 mg), and high-dose (8 mg) beluga lentil treatment groups. Beluga lentil was orally administered for 2 weeks, followed by bilateral renal ischemia for 20 min and reperfusion for 30 min. Blood samples and kidney tissues were collected and analyzed to investigate renal function, histopathology, epithelial and endothelial cell damage, apoptosis, oxidative stress, and inflammatory responses. Results. The pretreated groups maintained renal function, with significantly lower blood urea nitrogen (BUN) and creatinine levels, compared with the other groups. The histopathological analysis showed reduced proximal tubule injury and decreased injury-related molecule (kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL)) secretion in the pretreated groups compared with the other groups. Terminal deoxynucleotidyl transferase dUTP nick-end labeling- (TUNEL-) positive cells and the secretion of apoptosis-related molecules (Fas and caspase 3) were significantly reduced in the pretreated groups compared with the other groups. The pretreated groups showed positive microvessel-associated gene (cluster of differentiation (CD31)) expression and negative adhesion molecule (intracellular adhesion molecule 1 (ICAM-1)) expression. An antioxidant effect was observed in the pretreatment groups, with reduced malonaldehyde (MDA) expression and increased antioxidant enzyme (superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), and glutathione peroxidase (GPx)) secretion. In the pretreated groups, F4/80+ macrophages and CD4+ T cell infiltration were inhibited and proinflammatory cytokine (interleukin- (IL-) 1 beta, IL-6, and tumor necrosis factor- (TNF-) alpha) levels decreased; however, the levels of anti-inflammatory cytokines (transforming growth factor- (TGF-) beta, IL-10, and IL-22) increased. Conclusions. Beluga lentil pretreatment demonstrated protective effects against I/R-induced renal damage, via antiapoptotic, anti-inflammatory, and antioxidant activities. | Lee, Syng-ook; Chun, So Young; Lee, EunHye; Kim, Bomi; Yoon, BoHyun; Gil, Haejung; Kim, Dae Hwan; Jang, Byung Ik; Lee, Dong Woo; Yoo, Eun Sang; Park, Dong Jin; Lee, Jun Nyung; Han, Man-Hoon; Kim, Bum Soo; Song, Phil Hyun; Kwon, Tae Gyun; Ha, Yun-Sok | Keimyung Univ, Dept Food Sci & Technol, Daegu 42601, South Korea; Kyungpook Natl Univ Hosp, BioMed Res Inst, Daegu 41940, South Korea; Yeungnam Univ Hosp, Dept Lab Anim Res Support Team, Daegu 42415, South Korea; Yeungnam Univ, Coll Med, Dept Internal Med, Daegu 42415, South Korea; Kyungpook Natl Univ, Sch Med, Dept Urol, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pathol, Daegu 41566, South Korea; Yeungnam Univ, Coll Med, Dept Urol, Daegu 42415, South Korea | Kim, Young-Bo/AAR-8052-2021; Kim, Soo-Yeon/ADR-9663-2022; Lee, Jae-Sung/A-5236-2015; Lee, Jeong-Hoon/Q-1055-2018 | 12796984400; 8688166900; 57189661699; 57218929773; 57218931150; 57221906264; 55897992900; 22953491400; 57202974912; 7006609239; 57220636322; 16301364600; 57194067936; 57202817150; 8644562400; 15073765400; 35487226400 | tgkwon@knu.ac.kr;yunsokha@gmail.com; | BIOMED RESEARCH INTERNATIONAL | BIOMED RES INT | 2314-6133 | 2314-6141 | 2021 | SCIE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL | 2021 | 3.246 | 56.3 | 0.21 | 2025-07-30 | 3 | 4 | ISCHEMIA/REPERFUSION INJURY; KIDNEY INJURY; OXIDATIVE STRESS; INFLAMMATION; ACTIVATION; MOLECULE-1; RECEPTOR; MODEL | Administration, Oral; Animals; Apoptosis; Blood Urea Nitrogen; Kidney; Lens Plant; Male; Mice; Mice, Inbred ICR; Oxidative Stress; Plant Preparations; Protective Agents; Reperfusion Injury; caspase 3; catalase; complementary DNA; creatinine; DNA nucleotidylexotransferase; Fas ligand; glutathione; glutathione peroxidase; hepatitis A virus cellular receptor 1; herbaceous agent; intercellular adhesion molecule 1; interleukin 10; interleukin 1beta; interleukin 22; interleukin 6; malonaldehyde; neutrophil gelatinase associated lipocalin; nitrogen; platelet endothelial cell adhesion molecule 1; superoxide dismutase; transforming growth factor beta; tumor necrosis factor; urea; plant medicinal product; protective agent; animal experiment; animal model; animal tissue; antiapoptotic activity; antiinflammatory activity; antioxidant activity; apoptosis; Article; beluga lentil; blood sampling; CD4+ T lymphocyte; cell infiltration; clinical evaluation; comparative study; controlled study; drug effect; drug megadose; endothelium cell; enzyme linked immunosorbent assay; histopathology; kidney function; kidney ischemia; kidney proximal tubule; kidney tissue; kidney tubule; lentil; low drug dose; male; microvasculature; mouse; nonhuman; oxidative stress; protein expression; protein secretion; real time polymerase chain reaction; renal ischemia reperfusion injury; renal protection; reperfusion injury; TUNEL assay; urea nitrogen blood level; animal; Institute for Cancer Research mouse; kidney; metabolism; oral drug administration; pathology | English | 2021 | 2021-01-31 | 10.1155/2021/6890679 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Single-Dose Toxicity Study on ML171, a Selective NOX1 Inhibitor, in Mice | Background. ML171 is a potent nicotinamide adenine dinucleotide phosphate oxidase (NOX) inhibitor with isoform selectivity only for NOX1. This study is aimed at investigating the safety of ML171 after a single intraperitoneal (IP) injection in mice. Methods. The toxicity of a single dose of ML171 was evaluated in 6-week-old Institute of Cancer Research (ICR) mice in a good laboratory practice (GLP) laboratory. Twenty-five mice of each sex were assigned to five groups: negative control, vehicle control, and 125, 250, and 500 mg/kg of ML171. All mice were acclimatized for one week before beginning the study. Mice received an IP injection of ML171 or vehicle. The general condition and mortality of the animals were observed. The mice were sacrificed to evaluate histopathology 14 days after the administration of ML171 or vehicle. Results. Bodyweights were not significantly different in any group. Three males and one female died due to ML171 administration in the 500 mg/kg dose group. Autopsies of the surviving mice did not reveal any significant abnormalities after the injection of 125 mg/kg of ML171. However, the anterior lobe edge of the liver was thickened and adhesions between the liver and adjacent organs were observed in mice treated with 250 or 500 mg/kg of ML171. In addition, hypertrophy of centrilobular hepatocytes and inflammatory cell infiltration were observed after injection of 250 and 500 mg/kg of ML171. Conclusion. Our results indicate that the lethal IP injection dose of ML171 is 500 mg/kg for both males and females. Mortality were not observed for lower doses of ML171. The safe dose of single IP ML171 in ICR mice was 250 mg/kg or less. Further studies are needed to confirm the safety of ML171 in the human body. | Oh, Se-Hyun; Ahn, Ji-Sun; Oh, Eun-Joo; Kim, You-Jin; Yook, Ju-Min; Lim, Jeong-Hoon; Jung, Hee-Yeon; Choi, Ji-Young; Kim, Chan-Duck; Park, Sun-Hee; Kim, Yong-Lim; Cho, Jang-Hee | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Div Nephrol,Dept Internal Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, Daegu 41944, South Korea; Kyungpook Natl Univ, Dept Internal Med, Sch Med, Daegu 41944, South Korea | Lim, Jeong-Hoon/ABE-6003-2020; Kim, Yong-Lim/AGK-3172-2022; Park, Sun-Hee/LMN-0033-2024; Cho, Jang-hee/ABD-3534-2020 | 56053033900; 57191631694; 35783223700; 57190286137; 35110084800; 55360244300; 57196396467; 7501393222; 8558530700; 7501831741; 55633533600; 7403536291 | ttily@nate.com;ggumsuni@hanmail.net;oej1124@naver.com;pinkqic1004@naver.com;jumin18@hanmail.net;jh-lim@knu.ac.kr;hy-jung@knu.ac.kr;jyss1002@hanmail.net;drcdkim@knu.ac.kr;sh-park@knu.ac.kr;ylkim@knu.ac.kr;jh-cho@knu.ac.kr; | BIOMED RESEARCH INTERNATIONAL | BIOMED RES INT | 2314-6133 | 2314-6141 | 2021 | SCIE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL | 2021 | 3.246 | 56.3 | 0.07 | 2025-07-30 | 1 | 1 | NADPH OXIDASES; ROS; RAT | Animals; Drug Evaluation, Preclinical; Female; Male; Mice; Mice, Inbred ICR; NADPH Oxidase 1; Phenothiazines; Protein Isoforms; Toxicity Tests; 2 acetylphenothiazine; hy 12805; ml 171; oxidoreductase inhibitor; reduced nicotinamide adenine dinucleotide phosphate oxidase 1; unclassified drug; 2-acetylphenothiazine; isoprotein; NOX1 protein, mouse; phenothiazine derivative; reduced nicotinamide adenine dinucleotide phosphate oxidase 1; adhesion; adult; animal experiment; animal tissue; Article; autopsy; body weight; cell infiltration; controlled study; drug dose comparison; drug safety; female; general condition; histopathology; inflammatory cell; lethal dose; liver cell; liver hypertrophy; liver lobe; liver toxicity; male; mortality; mouse; nonhuman; single drug dose; survival; toxicity testing; animal; Institute for Cancer Research mouse; preclinical study | English | 2021 | 2021-05-30 | 10.1155/2021/5515478 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Transfer of Th17 from Adult Spontaneous Hypertensive Rats Accelerates Development of Hypertension in Juvenile Spontaneous Hypertensive Rats | Hypertension develops in the recipient rats that are transferred with the activated T helper (Th) 17 cells of the donor rats exposed to high-fructose or high-salt intake. This result suggests that a pathologic Th17 cell plays a role in the development and maintenance of hypertension. Here, we tested the hypothesis that the transfer of Th17 cells from adult spontaneous hypertensive rats (SHR) accelerates the development of hypertension in juvenile SHR. The tail-cuff method was used to measure systolic blood pressure. T cell (Th17 and regulatory T (Treg)) profiling was analyzed by flow cytometry. The expressions of Th17-related interleukin- (IL-) 17A and Treg-related IL-10 were measured by ELISA. Th17 cells isolated from adult SHR were intraperitoneally injected into juvenile recipient SHR and Wistar-Kyoto rats (WKY). SHR exhibited prominent development of hypertension at 15 weeks. The proportion of CD4(+)IL-17A(+) (Th17) cells among Th cells increased whereas the proportion of CD4(+)FoxP3(+) (Treg) cells decreased in SHR, as compared to WKY. The serum levels of IL-17A increased gradually with aging in SHR, but the serum levels of IL-10 did not. The serum levels of IL-17A and IL-10 seemed to be well related to the proportion of Th17 cells and Treg cells, respectively. Injection of Th17 cells isolated from adult SHR accelerates the development of hypertension in juvenile SHR but not in juvenile WKY though it increased the proportion of Th17 cells in juvenile recipient WKY and SHR. The transfer of Th17 cells from adult SHR accelerates the development of hypertension in juvenile SHR. These results implicate that the hypertension in SHR is ascribed to activation of Th17 cells. | Kim, Jee Young; Lee, Eunjo; Koo, Soohyeon; Kim, Cheong-Wun; Kim, InKyeom | Kyungpook Natl Univ, Sch Med, Dept Pharmacol, Daegu 41944, South Korea; Kyungpook Natl Univ, Cardiovasc Res Inst, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, BK21 Plus KNU Biomed Convergence Program, Daegu 41944, South Korea | 57222261625; 57190980166; 57222255070; 56662531400; 7404144630 | withjyk12@gmail.com;km2sh@naver.com;aimable9@hanmail.net;kcw7829@nate.com;inkim@knu.ac.kr; | BIOMED RESEARCH INTERNATIONAL | BIOMED RES INT | 2314-6133 | 2314-6141 | 2021 | SCIE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL | 2021 | 3.246 | 56.3 | 0.89 | 2025-07-30 | 14 | 14 | Animals; Blood Pressure; Disease Models, Animal; Hypertension; Interleukin-10; Interleukin-17; Lymphocyte Transfusion; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; T-Lymphocytes, Regulatory; Th17 Cells; CD3 antigen; CD4 antigen; interleukin 10; interleukin 17; pentobarbital; transcription factor FOXP3; Il17a protein, rat; interleukin 10; interleukin 17; adult; animal cell; animal experiment; animal model; animal tissue; Article; cell isolation; cell transfer; centrifugation; comparative study; controlled study; enzyme linked immunosorbent assay; flow cytometry; hypertension; juvenile animal; male; nonhuman; peripheral blood mononuclear cell; protein expression; rat; regulatory T lymphocyte; spontaneously hypertensive rat; systolic blood pressure; Th17 cell; Wistar Kyoto rat; animal; blood pressure; disease model; hypertension; immunology; lymphocyte transfusion; pathology; pathophysiology; transplantation | English | 2021 | 2021-02-20 | 10.1155/2021/6633825 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||||
| ○ | ○ | Article | Interferon-γ inhibits retinal neovascularization in a mouse model of ischemic retinopathy | Interferon-gamma (IFNG) is one of the key cytokines that regulates both innate and adaptive immune responses in the body. However, the role of IFNG in the regulation of vascularization, especially in the context of Vascular endothelial growth factor A (VEGFa)-induced angiogenesis is not clarified. Here, we report that IFNG shows potent anti-angiogenic potential against VEGFa-induced angiogenesis. IFNG significantly inhibited proliferation, migration, and tube formation of Human umbilical vein endothelial cells (HUVECs) both under basal and VEGFatreated conditions. Intriguingly, Knockdown (KD) of STAT1 abolished the inhibitory effect of IFNG on VEGFainduced angiogenic processes in HUVECs. Furthermore, IFNG exhibited potent anti-angiogenic efficacy in the mouse model of oxygen-induced retinopathy (OIR), an in vivo model for hypoxia-induced retinal neovascularization, without induction of functional side effects. Taken together, these results show that IFNG plays a crucial role in the regulation of VEGFa-dependent angiogenesis, suggesting its potential therapeutic applicability in neovascular diseases. | Jung, Inseong; Jung, Dokyung; Zha, Zhao; Jeong, Jongwon; Noh, Soojeong; Shin, Jiwon; Park, Jun-Kook; Kim, Kwang-Soo; Jeong, Youngtae; Hur, Jin; Baek, Moon-Chang; Diaz-Aguilar, Sophia; Aguilar, Edith; Friedlander, Martin; Bucher, Felicitas; Yea, Kyungmoo | DGIST, Dept New Biol, Daegu 42988, South Korea; Kyungpook Natl Univ, Sch Med, Dept Mol Med, Daegu 41944, South Korea; ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai 201210, Peoples R China; Pusan Natl Univ, Dept Convergence Med, Sch Med, Busan, South Korea; Scripps Res Inst, Dept Mol Med, La Jolla, CA USA; Univ Freiburg, Fac Med, Eye Ctr, Med Ctr, Freiburg, Germany | Zhaoyu, Zha/MGA-6354-2025; Jeong, Youngtae/M-7860-2015 | 57223306535; 57207487580; 57194795165; 57211276819; 57223308415; 57223303447; 57223285170; 57223290749; 56151139100; 59024329300; 7006013097; 57190765917; 7102769456; 7102298919; 37057078400; 12769131100 | felicitas.bucher@uniklinik-freiburg.de;ykm31@dgist.ac.kr; | CYTOKINE | CYTOKINE | 1043-4666 | 1096-0023 | 143 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CELL BIOLOGY;IMMUNOLOGY | 2021 | 3.926 | 56.4 | 0.32 | 2025-07-30 | 5 | 5 | IFNG; Angiogenesis; VEGFa; Wound healing; Tube formation; Endothelial cells | OXYGEN-INDUCED RETINOPATHY; CYTOKINE FUSION PROTEINS; ENDOTHELIAL-CELLS | Angiogenesis; Endothelial cells; IFNG; Tube formation; VEGFa; Wound healing | Animals; Cell Movement; Cell Proliferation; Disease Models, Animal; Down-Regulation; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia; Interferon-gamma; Intravitreal Injections; Ischemia; Mice; Neovascularization, Physiologic; Retina; Retinal Neovascularization; Signal Transduction; STAT1 Transcription Factor; gamma interferon; oxygen; STAT1 protein; vasculotropin A; gamma interferon; STAT1 protein; angiogenesis; animal cell; animal experiment; animal model; antiangiogenic activity; Article; cell migration; cell proliferation; controlled study; drug inhibition; gene control; gene knockdown; human; human cell; hypoxia; in vivo study; mouse; nonhuman; retina neovascularization; retinopathy; STAT1 gene; tubulogenesis; umbilical vein endothelial cell; VEGFa gene; animal; cell motion; complication; disease model; down regulation; drug effect; intravitreal drug administration; ischemia; metabolism; pathology; pathophysiology; retina; retina neovascularization; signal transduction | English | 2021 | 2021-07 | 10.1016/j.cyto.2021.155542 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | A Worker-Centered Personal Health Record App for Workplace Health Promotion Using National Health Care Data Sets: Design and Development Study | Background: Personal health record (PHR) technology can be used to support workplace health promotion, and prevent social and economic losses related to workers' health management. PHR services can not only ensure interoperability, security, privacy, and data quality, but also consider the user's perspective in their design. Objective: Using Fast Healthcare Interoperability Resources (FHIR) and national health care data sets, this study aimed to design and develop an app for providing worker-centered, interconnected PHR services. Methods: This study considered the user's perspective, using the human-centered design (HCD) methodology, to develop a PHR app suitable for occupational health. We developed a prototype after analyzing quantitative and qualitative data collected from workers and a health care professional group, after which we performed a usability evaluation. We structured workers' PHR items based on the analyzed data, and ensured structural and semantic interoperability using FHIR, Systematized Nomenclature of Medicine-Clinical Terms (SNOMED-CT), and Logical Observation Identifiers Names and Codes (LOINC). This study integrated workers' health information scattered across different Korean institutions through an interface method, and workers' PHRs were managed through a cloud server, using Azure API for FHIR. Results: In total, 562 workers from industrial parks participated in the quantitative study. The preferred data items for PHR were medication, number of steps walked, diet, blood pressure, weight, and blood glucose. The preferred features were ability to access medical checkup results, health information content provision, consultation record inquiry, and teleconsultation. The worker-centered PHR app collected data on, among others, life logs, vital signs, and medical checkup results; offered health care services such as reservation and teleconsultation; and provided occupational safety and health information through material safety data sheet search and health questionnaires. The app reflected improvements in user convenience and app usability proposed by 19 participants (7 health care professionals and 12 end users) in the usability evaluation. The After-Scenario Questionnaire (ASQ) was evaluated with a mean score of 5.90 (SD 0.34) out of 7, and the System Usability Scale (SUS) was evaluated a mean score of 88.7 (SD 4.83) out of 100. Conclusions: The worker-centered PHR app integrates workers' health information from different institutions and provides a variety of health care services from linked institutions through workers' shared PHR. This app is expected to increase workers' autonomy over their health information and support medical personnel's decision making regarding workers' health in the workplace. Particularly, the app will provide solutions for current major PHR challenges, and its design, which considers the user's perspective, satisfies the prerequisites for its utilization in occupational health. | Park, Hyun Sang; Kim, Kwang Il; Chung, Ho-Young; Jeong, Sungmoon; Soh, Jae Young; Hyun, Young Ho; Kim, Hwa Sun | BIT Comp Co Ltd, Digital Healthcare Dept, BIT Bldg 33,Seocho Daero 74 Gil, Seoul 06621, South Korea; Kyungpook Natl Univ, Dept Med Informat, Daegu, South Korea; Korea Occupat Safety & Hlth Agcy, Finance Programs Dept, Ulsan, South Korea; Elecmarvels Co Ltd, Daegu, South Korea | Park, HyunSang/KSM-9402-2024 | 56623579700; 57217134872; 56008255800; 23100090400; 54791376600; 57217131020; 59052965400 | hspark@bit.kr; | JMIR MEDICAL INFORMATICS | JMIR MED INF | 2291-9694 | 9 | 8 | SCIE | MEDICAL INFORMATICS | 2021 | 3.228 | 56.5 | 0.27 | 2025-07-30 | 5 | 9 | personal health record app; workplace health promotion; Fast Healthcare Interoperability Resources; national health care data set; human-centered design | INFORMATION; PATIENT; SYSTEM | Fast Healthcare Interoperability Resources; Human-centered design; National health care data set; Personal health record app; Workplace health promotion | English | 2021 | 2021-08 | 10.2196/29184 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Deep Learning Models for Predicting Severe Progression in COVID-19-Infected Patients: Retrospective Study | Background: Many COVID-19 patients rapidly progress to respiratory failure with a broad range of severities. Identification of high-risk cases is critical for early intervention. Objective: The aim of this study is to develop deep learning models that can rapidly identify high-risk COVID-19 patients based on computed tomography (CT) images and clinical data. Methods: We analyzed 297 COVID-19 patients from five hospitals in Daegu, South Korea. A mixed artificial convolutional neural network (ACNN) model, combining an artificial neural network for clinical data and a convolutional neural network for 3D CT imaging data, was developed to classify these cases as either high risk of severe progression (ie, event) or low risk (ie, event-free). Results: Using the mixed ACNN model, we were able to obtain high classification performance using novel coronavirus pneumonia lesion images (ie, 93.9% accuracy, 80.8% sensitivity, 96.9% specificity, and 0.916 area under the curve [AUC] score) and lung segmentation images (ie, 94.3% accuracy, 74.7% sensitivity, 95.9% specificity, and 0.928 AUC score) for event versus event-free groups. Conclusions: Our study successfully differentiated high-risk cases among COVID-19 patients using imaging and clinical features. The developed model can be used as a predictive tool for interventions in aggressive therapies. | Ho, Thao Thi; Park, Jongmin; Kim, Taewoo; Park, Byunggeon; Lee, Jaehee; Kim, Jin Young; Kim, Ki Beom; Choi, Sooyoung; Kim, Young Hwan; Lim, Jae-Kwang; Choi, Sanghun | Kyungpook Natl Univ, Sch Mech Engn, 80 Daehak Ro, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Med, Dept Radiol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Keimyung Univ, Dongsan Hosp, Dept Radiol, Daegu, South Korea; Daegu Fatima Hosp, Dept Radiol, Daegu, South Korea; Yeungnam Univ, Dept Radiol, Med Ctr, Daegu, South Korea; Daegu Catholic Univ, Sch Med, Dept Radiol, Daegu, South Korea | Lee, Jaehee/S-1697-2018; Lee, Jun Young/CAI-2335-2022; Choi, Sanghun/AGS-7430-2022; Kim, Juhee/KFS-3069-2024 | 57221374670; 57216463879; 57192910015; 57211532915; 13805476000; 55862597800; 59080545400; 57218715563; 57196174192; 55515341400; 55847101000 | s-choi@knu.ac.kr; | JMIR MEDICAL INFORMATICS | JMIR MED INF | 2291-9694 | 9 | 1 | SCIE | MEDICAL INFORMATICS | 2021 | 3.228 | 56.5 | 1.74 | 2025-07-30 | 23 | 29 | COVID-19; deep learning; artificial neural network; convolutional neural network; lung CT | PNEUMONIA; LUNG; CLASSIFICATION; TRANSMISSION; DIAGNOSIS | Artificial neural network; Convolutional neural network; COVID-19; Deep learning; Lung CT | English | 2021 | 2021-01 | 10.2196/24973 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Deep Learning Techniques for Fatty Liver Using Multi-View Ultrasound Images Scanned by Different Scanners: Development and Validation Study | Background: Fat fraction values obtained from magnetic resonance imaging (MRI) can be used to obtain an accurate diagnosis of fatty liver diseases. However, MRI is expensive and cannot be performed for everyone. Objective: In this study, we aim to develop multi-view ultrasound image-based convolutional deep learning models to detect fatty liver disease and yield fat fraction values. Methods: We extracted 90 ultrasound images of the right intercostal view and 90 ultrasound images of the right intercostal view containing the right renal cortex from 39 cases of fatty liver (MRI-proton density fat fraction [MRI-PDFF] >= 5%) and 51 normal subjects (MRI-PDFF < 5%), with MRI-PDFF values obtained from Good Gang-An Hospital. We obtained combined liver and kidney-liver (CLKL) images to train the deep learning models and developed classification and regression models based on the VGG19 model to classify fatty liver disease and yield fat fraction values. We employed the data augmentation techniques such as flip and rotation to prevent the deep learning model from overfitting. We determined the deep learning model with Results: In demographic information, all metrics such as age and sex were similar between the two groups-fatty liver disease and normal subjects. In classification, the model trained on CLKL images achieved 80.1% accuracy, 86.2% precision, and 80.5% specificity to detect fatty liver disease. In regression, the predicted fat fraction values of the regression model trained on CLKL images correlated with MRI-PDFF values (R2=0.633), indicating that the predicted fat fraction values were moderately estimated. Conclusions: With deep learning techniques and multi-view ultrasound images, it is potentially possible to replace MRI-PDFF values with deep learning predictions for detecting fatty liver disease and estimating fat fraction values. | Kim, Taewoo; Lee, Dong Hyun; Park, Eun-Kee; Choi, Sanghun | Kyungpook Natl Univ, Sch Mech Engn, 80 Daehak Ro, Daegu 41566, South Korea; Good Gang An Hosp, Div Gastroenterol, Dept Internal Med, Busan, South Korea; Kosin Univ, Dept Med Humanities & Social Med, Coll Med, Busan, South Korea | ; Choi, Sanghun/AGS-7430-2022 | 57192910015; 57208050302; 57216814178; 55847101000 | s-choi@knu.ac.kr; | JMIR MEDICAL INFORMATICS | JMIR MED INF | 2291-9694 | 9 | 11 | SCIE | MEDICAL INFORMATICS | 2021 | 3.228 | 56.5 | 0.87 | 2025-07-30 | 11 | 16 | fatty liver; deep learning; transfer learning; classification; regression; magnetic resonance imaging-proton density fat fraction; multi-view ultrasound images; artificial intelligence; machine imaging; imaging; informatics; fatty liver disease; detection; diagnosis | NONINVASIVE DIAGNOSIS; DISEASE; QUANTIFICATION; STEATOSIS; BIOPSIES; FRACTION | Artificial intelligence; Classification; Deep learning; Detection; Diagnosis; Fatty liver; Fatty liver disease; Imaging; Informatics; Machine imaging; Magnetic resonance imaging-proton density fat fraction; Multi-view ultrasound images; Regression; Transfer learning | English | 2021 | 2021-11 | 10.2196/30066 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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