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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Objective Bayesian group variable selection for linear model | Prediction variables of the regression model are grouped in many application problems. For example, a factor in an analysis of variance can have several levels or each original prediction variable in additive models can be expanded into different order polynomials or a set of basis functions. It is essential to select important groups and individual variables within the selected groups. In this study, we propose the objective Bayesian group and individual variable selections within the selected groups in the regression model to reduce the computational cost, even though the number of regression variables is large. Besides, we examine the consistency of the proposed group variable selection procedure. The proposed objective Bayesian approach is investigated using simulation and real data examples. The comparisons between the penalized regression approaches, Bayesian group lasso and the proposed method are presented. | Kang, Sang Gil; Lee, Woo Dong; Kim, Yongku | Sangji Univ, Dept Comp & Data Informat, Wonju 26339, South Korea; Daegu Haany Univ, Premajor Cosmet & Pharmaceut, Kyungsan 38610, South Korea; Kyungpook Natl Univ, Dept Stat, Daegu 41566, South Korea | 56119861400; 8328822200; 47962102500 | sangkg@sangji.ac.kr;wdlee@dhu.ac.kr;kim.1252@knu.ac.kr; | COMPUTATIONAL STATISTICS | COMPUTATION STAT | 0943-4062 | 1613-9658 | 37 | 3 | SCIE | STATISTICS & PROBABILITY | 2022 | 1.3 | 55.6 | 0.16 | 2025-06-25 | 1 | 1 | Bayes factor; Group variable selection; Intrinsic prior; Linear regression model | REGRESSION; CONSISTENCY | Bayes factor; Group variable selection; Intrinsic prior; Linear regression model | English | 2022 | 2022-07 | 10.1007/s00180-021-01160-w | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Article | Growth, optical, and luminescence characterization of LiCsMoO4 crystal | A crack-free LiCsMoO4 crystal was grown with the conventional Czochralski technique. The optical properties of the crystal show it transparent well in the visible region. The luminescence properties of the crystal were studied from 300 to 14 K under the excitation with a 280 nm light-emitting diode (LED). At room temperature, the luminescence light yield is low; however, it increases significantly at low temperatures. The decay time of the crystal is measured under the excitation of the crystal with the 280 nm LED source. The decay times at all the temperatures are fitted with three exponential functions. The average decay time from 300 to 14 K varies from 6.7 to 8.6 mu s. A thermoluminescence (TL) study of the crystal was carried out from 9 to 300 K. Three TL peaks are found between 165 and 250 K. This study shows that the developed crystal has a potential application in search of neutrinoless double-beta decay of Mo-100 at cryogenic temperatures. | Pandey, Indra Raj; Khan, Sajid; Khan, Arshad; Kim, Y. D.; Kim, H. J.; Lee, Moo Hyun | Inst Basic Sci IBS, Ctr Underground Phys, Daejeon 34126, South Korea; Northwestern Univ, Dept Chem, Evanston, IL 60208 USA; Argonne Natl Lab, Div Mat Sci, Lemont, IL 60439 USA; Kohat Univ Sci & Technol, Dept Phys, Kohat 26000, Pakistan; Kyungpook Natl Univ, Ctr High Energy Phys, Daegu 41566, South Korea; Univ Sci & Technol UST, IBS Sch, Daejeon 34113, South Korea | ; Kim, Hong Joo/AAE-1178-2022; khan, sajid/HGE-2406-2022; Lee, Moo/AAK-4266-2020; Khan, Arshad/ABB-1566-2021 | mhlee@ibs.re.kr; | JOURNAL OF CRYSTAL GROWTH | J CRYST GROWTH | 0022-0248 | 1873-5002 | 580 | SCIE | CRYSTALLOGRAPHY;MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED | 2022 | 1.8 | 55.8 | 1 | Crystal; Optical; Luminescence; Thermoluminescence; Conventional Czochralski technique | DOUBLE-BETA DECAY; SINGLE-CRYSTALS; SCINTILLATORS; CONVERSION | English | 2022 | 2022-02-15 | 10.1016/j.jcrysgro.2021.126466 | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | ○ | Article | The relationship between sleep quality, neck pain, shoulder pain and disability, physical activity, and health perception among middle-aged women: a cross-sectional study | Background Sleep quality is an important physical requirement for a healthy life, and good sleep quality has been recognized as a significant component in physical and mental health and well-being. The purpose of this study was to identify the factors that affect sleep quality as well as the relationship between sleep quality and neck pain, shoulder pain and disability, physical activity, and health perception. Methods We conducted surveys on 494 women between the age of 35 and 64 years. The study evaluated neck pain, shoulder pain and disability, physical activity, self-health perception and sleep quality with self-reported questionnaires in middle-aged women. Data were analyzed using SPSS 23.0. Results The results showed that the more severe the neck pain and shoulder pain and disability, the worse the sleep quality was in middle-aged women and the better the health perception, the lower the sleep quality score was, indicating good sleep quality. Shoulder pain, self-perceived task difficulty, and health perception were identified as variables that affected the sleep quality in middle-aged women. The explanatory power of the model in explaining sleep quality was 22.9%. Conclusions Worsened shoulder pain, self-perceived task difficulty, and negative health perception can affect poor sleep quality; therefore, it is necessary to develop health interventions for pain management and emotional and social support for improving daily sleep quality. To improve the sleep quality in middle-aged women, healthcare workers should consider the subjects' pain and functional disability, in accordance with their health perception. | Lee, Myung Kyung; Oh, Jihyun | Kyungpook Natl Univ, Coll Nursing, Res Inst Nursing Sci, Daegu 41944, South Korea; Kongju Natl Univ, Coll Nursing & Hlth, Dept Nursing, Kong Ju 32588, South Korea | 40661513200; 57207574572 | jihyunoh3star@kongju.ac.kr; | BMC WOMENS HEALTH | BMC WOMENS HEALTH | 1472-6874 | 22 | 1 | SCIE;SSCI | OBSTETRICS & GYNECOLOGY;PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | 2022 | 2.5 | 55.8 | 2.66 | 2025-06-25 | 11 | 16 | Sleep quality; Shoulder pain; Women; Health perception; Neck pain | CARDIOVASCULAR-DISEASE; OLDER-ADULTS; SYMPTOMS; PRODUCTIVITY; PREVALENCE; DISORDERS; DURATION; EFFICACY; OBESITY; WORKERS | Health perception; Neck pain; Shoulder pain; Sleep quality; Women | Adult; Cross-Sectional Studies; Exercise; Female; Humans; Middle Aged; Neck Pain; Perception; Shoulder Pain; Sleep Quality; Surveys and Questionnaires; adult; analgesia; Article; cross-sectional study; descriptive research; disability; emotional support; female; Habitual sleep efficiency; health care; health care personnel; human; human experiment; international physical activity questionnaire; metabolic equivalent; metabolic parameters; neck pain; nervous system parameters; Northwick Park Neck Pain Questionnaire; perception; physical activity; Pittsburgh Sleep Quality Index; questionnaire; reliability; scoring system; shoulder pain; Shoulder Pain and Disability Index; sleep disorder; sleep efficiency; sleep latency; sleep parameters; sleep quality; sleep time; social support; sociodemographics; somnolence; walking; exercise; middle aged; perception; psychology; sleep quality | English | 2022 | 2022-05-21 | 10.1186/s12905-022-01773-3 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Additive effect of probiotics (Mutaflor) on 5-aminosalicylic acid therapy in patients with ulcerative colitis | Background/Aims: In ulcerative colitis (UC) patients, Escherichia coli Nissle 1917 (EcN) is equivalent to mesalazine for preventing disease relapse; however, evidence of the ability of EcN to increase health-related quality of life or induce remission remains scarce. We investigated the efficacy of EcN as an add-on therapy for UC. Methods: In this multicentre, double-blind, randomised, placebo-controlled study, a total of 133 UC patients were randomly assigned to receive either EcN or placebo once daily for 8 weeks. Inflammatory bowel disease questionnaire (IBDQ) scores (primary endpoint) and clinical remission and response rates (secondary endpoints) were compared (Clinical trial registration number: NCT04969679). Results: In total, 118 patients (EcN, 58; placebo, 60) completed the study. The number of patients reaching the primary endpoint did not differ between the EcN and placebo groups (30 [51.7%] vs. 31 [51.7%]; per-protocol analysis, p = 1.0; intention-to-treat analysis, p = 0.86). However, significantly fewer patients in the EcN group exhibited a decreased IBDQ score (1 [1.7%] vs. 8 [13.3%]; per-protocol analysis, p = 0.03; intention-to-treat analysis, p = 0.02). Moreover, a significantly higher number of patients in the EcN group displayed clinical response at 4 weeks (23 [39.7%] vs. 13 [21.7%], p = 0.04) and endoscopic remission at 8 weeks (26 [46.4%] vs. 16 [27.1%], p = 0.03). Conclusions: Although the number of patients reaching the primary endpoint did not differ between the EcN and placebo groups, EcN was found to be safe and effective in preventing the exacerbation of IBDQ scores and achieving clinical responses and endoscopic remission in patients with mild-to-moderate UC. | Park, Soo-Kyung; Kang, Sang-Bum; Kim, SangSoo; Kim, Tae Oh; Cha, Jae Myung; Im, Jong Pil; Choi, Chang Hwan; Kim, Eun Soo; Seo, Geom Seog; Eun, Chang Soo; Han, Dong Soo; Park, Dong Il | Sungkyunkwan Univ, Kangbuk Samsung Hosp, Div Gastroenterol, Dept Internal Med,Sch Med, Seoul, South Korea; Catholic Univ Korea, Daejeon St Marys Hosp, Div Gastroenterol, Dept Internal Med,Coll Med, Daejeon, South Korea; Soongsil Univ, Dept Bioinformat, Seoul, South Korea; Inje Univ, Dept Internal Med, Haeundae Paik Hosp, Busan, South Korea; Kyung Hee Univ Hosp Gangdong, Dept Internal Med, Seoul, South Korea; Seoul Natl Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Seoul Natl Univ, Liver Res Inst, Coll Med, Seoul, South Korea; Chung Ang Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Div Gastroenterol & Hepatol, Dept Internal Med, Daegu, South Korea; Wonkwang Univ, Digest Dis Res Inst, Dept Internal Med, Sch Med, Iksan, South Korea; Hanyang Univ, Dept Internal Med, Guri Hosp, Guri, South Korea | Cheon, Jung-Eun/J-5684-2012; Kwak, Sang Gyu/AAG-4341-2021; Kim, Sang/J-5398-2012; Kim, Hyung/J-5451-2012; Han, Dong/P-1753-2015 | 57221712520; 8837205700; 57201923850; 57189056554; 57203991065; 8108755200; 56799609000; 57203086704; 7006501197; 7004074626; 14621423900; 56524839700 | diksmc.park@samsung.com; | KOREAN JOURNAL OF INTERNAL MEDICINE | KOREAN J INTERN MED | 1226-3303 | 2005-6648 | 37 | 5 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 2.4 | 55.9 | 2.03 | 2025-06-25 | 19 | 19 | Escherichia coli Nissle 1917; Colitis; ulcerative; Quality of life | ESCHERICHIA-COLI; NISSLE 1917; MICROBIOTA; MANAGEMENT | Colitis, ulcerative; Escherichia coli Nissle 1917; Quality of life | mesalazine; mutaflor; placebo; adult; Article; clinical outcome; controlled study; double blind procedure; drug efficacy; endoscopy; female; human; intention to treat analysis; major clinical study; male; middle aged; multicenter study; quality of life; questionnaire; randomized controlled trial; remission; scoring system; treatment response; ulcerative colitis | English | 2022 | 2022-09 | 10.3904/kjim.2021.458 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Control of buoyant flow and heat dissipation in a porous annular chamber using a thin baffle | This paper reports the numerical simulations on buoyant thermal transfer inside the finite porous cylindrical annular region with a thin circular baffle attached to inner cylinder. The main objective of this investigation is to provide a detailed impact of baffle on flow and heat transport rates due to the direct relevance of this problem to the design of heat exchangers. The side walls of annular enclosure are maintained at uniform, but different temperatures, while the top and bottom walls are insulated. The Brinkman-extended Darcy model is adopted for the momentum equations, and simulations of the governing PDEs are performed using the ADI and SLOR algorithms. The predictions from the present simulations detected that the size and position of baffle has predominant impact on buoyant flow and thermal transport characteristics. It has been detected that the thermal dissipation rates could be enhanced by positioning the baffle near the upper boundary, while increasing the baffle length leads to the reduction of thermal transport. The size and location of baffle emerges out as an important quantity in regulating the global thermal transfer through modifying the flow regimes in the annular geometry. Interestingly, the magnitude of flow circulation enhances with an increase in Rayleigh and Darcy numbers for any baffle length and position. | Pushpa, B. V.; Do, Younghae; Sankar, M. | BMS Inst Technol & Management, Dept Math, Bengaluru 560064, India; Kyungpook Natl Univ, Dept Math, KNU Ctr Nonlinear Dynam, Daegu 41566, South Korea; Univ Technol & Appl Sci CAS Ibri, Gen Requirements Dept, Fac Math, POB 14, Ibri 516, Oman; Presidency Univ, Sch Engn, Dept Math, Bengaluru 560064, India | ; Mani, Sankar/AAT-5256-2021; V, Pushpa/ABG-3360-2020; Do, Younghae/G-3522-2011 | 57197732823; 7103101109; 6701530391 | manisankariyer@gmail.com; | INDIAN JOURNAL OF PHYSICS | INDIAN J PHYS | 0973-1458 | 0974-9845 | 96 | 6 | SCIE | PHYSICS, MULTIDISCIPLINARY | 2022 | 2 | 55.9 | 0.65 | 2025-06-25 | 9 | 8 | Annulus enclosure; Baffle; Porous; Darcy-Brinkman model; Finite difference method | NATURAL-CONVECTION; SQUARE ENCLOSURE; THERMOSOLUTAL CONVECTION; DISCRETE HEAT; CAVITY; FIN; PLATE; OPTIMIZATION; FLUX | Annulus enclosure; Baffle; Darcy-Brinkman model; Finite difference method; Porous | English | 2022 | 2022-05 | 10.1007/s12648-021-02120-2 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Executive summary of the Korean Society of Nephrology 2021 clinical practice guideline for optimal hemodialysis treatment | The Korean Society of Nephrology (KSN) has published a clinical practice guideline (CPG) document for maintenance hemodialysis (HD). The document, 2021 Clinical Practice Guideline on Optimal HD Treatment, is based on an extensive evidence-oriented review of the benefits of preparation, initiation, and maintenance therapy for HD, with the participation of representative experts from the KSN under the methodologists??? support for guideline development. It was intended to help clinicians participating in HD treatment make safer and more effective clinical decisions by providing user-friendly guidelines. We hope that this CPG will be meaningful as a recommendation in practice, but not on a regulatory rule basis, as different approaches and treatments may be used by health care providers depending on the individual patient???s condition. This CPG consists of eight sections and 15 key questions. Each begins with statements that are graded by the strength of recommendations and quality of the evidence. Each statement is followed by a summary of the evidence supporting the recommendations. There are also a link to full-text documents and lists of the most important reports so that the readers can read further (most of this is available online). | Jung, Ji Yong; Yoo, Kyung Don; Kang, Eunjeong; Kang, Hee Gyung; Kim, Su Hyun; Kim, Hyoungnae; Kim, Hyo Jin; Park, Tae-Jin; Suh, Sang Heon; Jeong, Jong Cheol; Choi, Ji-Young; Hwang, Young-Hwan; Choi, Miyoung; Kim, Yae Lim; Oh, Kook-Hwan | Gachon Univ, Gil Med Ctr, Dept Internal Med, Div Nephrol,Coll Med, Incheon, South Korea; Univ Ulsan, Ulsan Univ Hosp, Dept Internal Med, Div Nephrol,Coll Med, Ulsan, South Korea; Ewha Womans Univ, Ewha Womans Coll Med, Dept Internal Med, Div Nephrol,Seoul Hosp, Seoul, South Korea; Seoul Natl Univ, Dept Pediat, Div Pediat Nephrol, Childrens Hosp, Seoul, South Korea; Chung Ang Univ Hosp, Dept Internal Med, Div Nephrol, Seoul, South Korea; Soonchunhyang Univ, Dept Internal Med, Div Nephrol, Seoul Hosp, Seoul, South Korea; Pusan Natl Univ Hosp, Dept Internal Med, Div Nephrol, Busan, South Korea; Asan Jin Internal Med Clin, Seoul, South Korea; Chonnam Natl Univ Hosp, Dept Internal Med, Div Nephrol, Gwangju, South Korea; Seoul Natl Univ, Dept Internal Med, Div Nephrol, Bundang Hosp, Seongnam, South Korea; Kyungpook Natl Univ, Dept Internal Med, Div Nephrol, Chilgok Hosp, Daegu, South Korea; Truewords Dialysis Clin, Incheon, South Korea; Natl Evidence Based Healthcare Collaborating Agcy, Div Healthcare Technol Assessment Res, Seoul, South Korea; Korea Univ, Dept Biostat, Coll Med, Seoul, South Korea; Seoul Natl Univ Hosp, Dept Internal Med, Div Nephrol, Seoul, South Korea | Oh, Kook-Hwan/MDS-5373-2025; Kim, Su Hyun/JPY-2079-2023; Kim, Hyoungnae/JXN-1329-2024; Suh, Sang Heon/HPF-8024-2023; Choi, Miyoung/HZH-8501-2023; Yoo, Kyung/AAK-8096-2020 | 36183333400; 56603636300; 56577278700; 7404071546; 57196229394; 57191261788; 58366794000; 57228083300; 54789242500; 37761626800; 7501393222; 18835804300; 57129603200; 57284808100; 7402728369 | khoh@snu.ac.kr; | KOREAN JOURNAL OF INTERNAL MEDICINE | KOREAN J INTERN MED | 1226-3303 | 2005-6648 | 37 | 4 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 2.4 | 55.9 | 0.11 | 2025-06-25 | 2 | 1 | Practice guideline; Hemodialysis units; hospital; Evidence-based practice; GRADE approach | MOLECULAR-WEIGHT HEPARIN; HIGH-FLUX HEMODIALYSIS; BLOOD-PRESSURE CONTROL; QUALITY-OF-LIFE; LEFT-VENTRICULAR HYPERTROPHY; RESIDUAL RENAL-FUNCTION; CHRONIC KIDNEY-DISEASE; UREA REDUCTION RATIO; ALL-CAUSE MORTALITY; ONLINE HEMODIAFILTRATION | Evidence-based practice; GRADE approach; Hemodialysis units, hospital; Practice guideline | adult; article; clinical practice; GRADE approach; health care personnel; hemodialysis; human; maintenance therapy; nephrology; practice guideline | English | 2022 | 2022-07 | 10.3904/kjim.2021.543 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Influence of the sorption pressure and K2CO3 loading of a MgO-based sorbent for application to the SEWGS process | MgO-based sorbents were prepared by impregnation with K2CO3 at different loadings. This study examined the CO2 absorption and regeneration properties of MgO-based sorbents at various pressures. The CO2 capture capacity of the PMI-30 sorbent increased to 204.4 mg CO2/g sorbent with increasing absorption pressure through CO2 absorption by MgO itself and K2CO3 by generating structures, such as MgCO3 center dot 3H(2)O and K2Mg(CO3)(2). However, no KHCO3 phase was observed after CO2 absorption at 1, 10, and 20 atm. The CO2 capture capacity of the MgO and PMI-10, 20, 30, and 40 sorbents was the 94.6, 129.9, 156.6, 204.4, and 239.4 mg CO2/g sorbent, respectively. The CO2 capture capacity of MgO in the PMI sorbent was relatively constant regardless of the decreasing MgO content and increasing K2CO3 content. The CO2 absorption ability of MgO was calculated by substracting theoretical CO2 capture capacity of K2CO3 from the total capacity of sorbents. The TPD experiment performed at 1 atm after CO2 absorption at 20 atm showed that the regeneration temperature of the PMI sorbents differed according to the K2CO3 loading. | Ryu, Do Yeong; Jo, Seongbin; Kim, Tae-Young; In, Soo Yeong; Kim, Jae Kuk; Hwang, Jae Eun; Kim, Jae Chang; Lee, Soo Chool | Kyungpook Natl Univ, Dept Chem Engn, Daegu 41566, South Korea; JnK Co Ltd, Daegu 41566, South Korea; Univ Calif Riverside, Dept Chem & Environm Engn, Riverside, CA 92521 USA; Kyungpook Natl Univ, Res Inst Adv Energy Technol, Daegu 41566, South Korea | Kim, Yu/L-8480-2017; Jo, SeongBin/MFJ-9000-2025 | 57409454800; 57190754848; 57208461628; 57408939900; 57408595000; 57408940000; 55382762400; 8524020100 | kjchang@knu.ac.kr;soochool@knu.ac.kr; | KOREAN JOURNAL OF CHEMICAL ENGINEERING | KOREAN J CHEM ENG | 0256-1115 | 1975-7220 | 39 | 4 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;ENGINEERING, CHEMICAL | 2022 | 2.7 | 55.9 | 0.35 | 2025-06-25 | 5 | 5 | CO2 capture; pre-combustion; K2CO3; MgO-based sorbent; K2Mg(CO3)(2) | CARBON-DIOXIDE CAPTURE; CO2 CAPTURE; HIGH-TEMPERATURE; HYDROTALCITE; GAS; ALUMINA | CO<sub>2</sub> capture; K<sub>2</sub>CO<sub>3</sub>; K<sub>2</sub>Mg(CO<sub>3</sub>)<sub>2</sub>; MgO-based sorbent; pre-combustion | English | 2022 | 2022-04 | 10.1007/s11814-021-0967-1 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Insufficient early renal recovery and progression to subsequent chronic kidney disease in living kidney donors | Background/Aims: Renal recovery of a kidney donor after undergoing nephrectomy though challenging is essential. We aimed to examine the effect of estimated glomerular filtration rate (eGFR) percent change at 1-month post-donation on insufficient kidney function after kidney donation. Methods: A total of 3,952 living kidney donors who underwent donor nephrectomy from 1982 to 2019 from eight different tertiary hospitals in Korea were initially screened. Percent changes in the eGFR from baseline to 1-month post-donation were calculated. The degree of percent changes was categorized by quartile, and the 1st quartile was regarded as the group with the lowest decreased eGFR at 1-month after donation. The remaining eGFR less than 60 mL/min/1.73 m(2) was the endpoint. The Cox proportional hazard model was used for evaluating the impact of initial eGFR and eGFR percent change at 1-month post-donation on the condition with remaining eGFR < 60 mL/min/1.73 m(2). In the multivariate analysis, we used variables with a p < 0.1 in the univariate analysis. Results: A total of 1,585 donors were included in the analysis. During 62.2 +/- 49.3 months, 13.7% of donors showed renal insufficiency. The 4th (adjusted hazard ratio [aHR], 10.41; 95% confidence interval [CI], 5.15 to 21.04) and the 3rd (aHR, 4.29; 95% CI, 2.15 to 8.56) quartiles of percent change in eGFR and the pre-donation eGFR (aHR, 0.90; 95% CI, 0.88 to 0.92) were associated with the development of renal insufficiency. Conclusions: The impact of worse initial renal recovery on renal insufficiency was pronounced in donors with lower pre-donation eGFRs. Additionally, worse initial renal recovery of remaining kidney affected the long-term development of renal insufficiency in kidney donors. | Kim, Yaerim; Kang, Eunjeong; Chae, Dong-Wan; Lee, Jung Pyo; Lee, Sik; Kim, Soo Wan; Cho, Jang-Hee; Han, Miyeun; Han, Seungyeup; Kim, Yong Chul; Kim, Dong Ki; Joo, Kwon Wook; Kim, Yon Su; Lee, Hajeong | Keimyung Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Ewha Womans Univ, Seoul Hosp, Seoul, South Korea; Seoul Natl Univ, Bundang Hosp, Seongnam, South Korea; Seoul Natl Univ, Boramae Med Ctr, Seoul Metropolitan Govt, Seoul, South Korea; Jeonbuk Natl Univ Hosp, Jeonju, South Korea; Chonnam Natl Univ, Sch Med, Gwangju, South Korea; Kyungpook Natl Univ, Sch Med, Daegu, South Korea; Hallym Univ, Hangang Sacred Heart Hosp, Seoul, South Korea; Seoul Natl Univ Hosp, Seoul, South Korea | Joo, Kwon/J-5675-2012; Kim, Yong/L-8653-2019; Kim, Dong Ki/J-5389-2012; Cho, Jang-hee/ABD-3534-2020; Lee, Hyo/G-6299-2019; Lee, Jun-Young/N-5963-2019; Kim, Nan/T-8627-2019; Han, Seung Seok/HGD-2825-2022; Chae, Dong-Wan/J-5681-2012; Kim, Sang/J-5399-2012 | 57202790600; 56577278700; 23471686900; 56028990400; 57192521521; 56108124300; 7403536291; 55899659500; 24281360600; 57026583000; 23479259100; 7101808967; 7410205767; 36554389800 | mdhjlee@gmail.com; | KOREAN JOURNAL OF INTERNAL MEDICINE | KOREAN J INTERN MED | 1226-3303 | 2005-6648 | 37 | 5 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 2.4 | 55.9 | 0.75 | 2025-06-25 | 8 | 7 | Renal insufficiency; chronic; Early renal recovery; Living donors; Kidney | Early renal recovery; Kidne; Living donors; Renal insufficiency, chronic | Glomerular Filtration Rate; Humans; Kidney; Kidney Transplantation; Living Donors; Nephrectomy; Renal Insufficiency, Chronic; Retrospective Studies; albumin; calcium; cholesterol; glucose; hemoglobin; phosphorus; uric acid; adult; Article; body mass; chronic kidney failure; estimated glomerular filtration rate; female; human; kidney donor; kidney function; living donor; major clinical study; male; nephrectomy; risk factor; systolic blood pressure; adverse event; chronic kidney failure; glomerulus filtration rate; kidney; kidney transplantation; living donor; retrospective study | English | 2022 | 2022-09 | 10.3904/kjim.2021.308 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Laboratory and radiological discrimination between tuberculous and malignant pleural effusions with high adenosine deaminase levels | Background/Aims: Pleural fluid adenosine deaminase (ADA) levels are useful in discriminating tuberculous pleural effusions (TPEs) from malignant pleural effusions (MPEs). However, some patients with MPE exhibit high-ADA levels, which may mimic TPEs. There is limited data regarding the differential diagnosis between high-ADA MPE and high-ADA TPE. This study aimed to identify the predictors for distinguishing high-ADA MPEs from high-ADA TPEs. Methods: Patients with TPE and MPE with pleural fluid ADA levels >= 40 IU/L were included in this study. Clinical, laboratory, and radiological data were compared between the two groups. Independent predictors and their diagnostic performance for high-ADA MPEs were evaluated using multivariate logistic regression analysis and receiver operating characteristic curve. Results: A total of 200 patients (high-ADA MPE, n = 30, and high-ADA TPE, n = 170) were retrospectively included. In the multivariate analysis, pleural fluid ADA, pleural fluid carcinoembryonic antigen (CEA), and pleural nodularity were independent discriminators between high-ADA MPE and high-ADA TPE groups. Using pleural ADA level of 40 to 56 IU/L (3 points), pleural CEA level >= 6 ng/mL (6 points), and presence of pleural nodularity (3 points) for predicting high-ADA MPEs, a sum score >= 6 points yielded a sensitivity of 90%, specificity of 96%, positive predictive value of 82%, negative predictive value of 98%, and area under the receiver operating characteristic curve of 0.965. Conclusions: A scoring system using three parameters may be helpful in guiding the differential diagnosis between highADA MPEs and high-ADA TPEs. | Lee, Jaehee; Park, Ji Eun; Ha Choi, Sun; Seo, Hyewon; Lee, Sang Yub; Lim, Jae Kwang; Yoo, Seung Soo; Lee, Shin Yup; Cha, Seung Ick; Park, Jae Yong; Kim, Chang Ho | Kyungpook Natl Univ, Sch Med, Dept Internal Med, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Radiol, Daegu, South Korea | Lee, Joo/C-3851-2013; Lee, Yoojin/AAB-9799-2022; Lee, Jaehee/S-1697-2018 | 13805476000; 57195437358; 57199723585; 55612130200; 56016177400; 55515341400; 56479781600; 49863712700; 35227126400; 58360293800; 7409873555 | kimch@knu.ac.kr; | KOREAN JOURNAL OF INTERNAL MEDICINE | KOREAN J INTERN MED | 1226-3303 | 2005-6648 | 37 | 1 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 2.4 | 55.9 | 0.96 | 2025-06-25 | 10 | 10 | Adenosine deaminase; Carcinoembryonic antigen; Malignant pleural effusions; Pleural nodularity; Pleural tuber-culosis | CARCINOEMBRYONIC ANTIGEN; DIFFERENTIAL-DIAGNOSIS; CT FINDINGS; FLUID; BENIGN | Adenosine deaminase; Carcinoembryonic antigen; Malignant pleural effusions; Pleural nodularity; Pleural tuberculosis | Adenosine Deaminase; Carcinoembryonic Antigen; Diagnosis, Differential; Humans; Pleural Effusion; Pleural Effusion, Malignant; Retrospective Studies; Sensitivity and Specificity; Tuberculosis; Tuberculosis, Pleural; adenosine deaminase; antineoplastic agent; carcinoembryonic antigen; adenosine deaminase; carcinoembryonic antigen; adenosine deaminase pleura fluid level; adult; aged; analytical parameters; Article; calorimetry; carcinoembryonic antigen pleura fluid level; clinical assessment; computer assisted tomography; contrast enhancement; controlled study; data analysis; diagnostic accuracy; diagnostic test accuracy study; diagnostic value; differential diagnosis; enzyme analysis; female; human; human cell; human tissue; immunoassay; laboratory test; major clinical study; male; malignant pleura effusion; middle aged; multivariate logistic regression analysis; nonhuman; pleura disease; pleura effusion; pleura fluid; pleural nodularity; prediction; predictive value; radiometry; receiver operating characteristic; reference value; retrospective study; scoring system; sensitivity and specificity; thorax radiography; tuberculous pleural effusion; tuberculous pleurisy; very elderly; diagnostic imaging; differential diagnosis; malignant pleura effusion; pleura effusion; tuberculosis | English | 2022 | 2022-01 | 10.3904/kjim.2020.246 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Review | Omics-based biomarkers for diagnosis and prediction of kidney allograft rejection | Kidney transplantation is the preferred treatment for patients with end-stage kidney disease, because it prolongs survival and improves quality of life. Allograft biopsy is the gold standard for diagnosing allograft rejection. However, it is invasive and reactive, and continuous monitoring is unrealistic. Various biomarkers for diagnosing allograft rejection have been developed over the last two decades based on omics technologies to overcome these limitations. Omics technologies are based on a holistic view of the molecules that constitute an individual. They include genomics, transcriptomics, proteomics, and metabolomics. The omics approach has dramatically accelerated biomarker discovery and enhanced our understanding of multifactorial biological processes in the field of transplantation. However, clinical application of omics-based biomarkers is limited by several issues. First, no large-scale prospective randomized controlled trial has been conducted to compare omics-based biomarkers with traditional biomarkers for rejection. Second, given the variety and complexity of injuries that a kidney allograft may experience, it is likely that no single omics approach will suffice to predict rejection or outcome. Therefore, integrated methods using multiomics technologies are needed. Herein, we introduce omics technologies and review the latest literature on omics biomarkers predictive of allograft rejection in kidney transplant recipients. | Lim, Jeong-Hoon; Ha Chung, Byung; Lee, Sang-Ho; Jung, Hee-Yeon; Choi, Ji-Young; Cho, Jang-Hee; Park, Sun-Hee; Kim, Yong-Lim; Kim, Chan-Duck | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Internal Med, Seoul, South Korea; Kyung Hee Univ, Coll Med, Dept Internal Med, Seoul, South Korea | ; Jung, Hee-Yeon/AFB-8578-2022; Kim, Yong-Lim/AGK-3172-2022; Lim, Jeong-Hoon/ABE-6003-2020; Cho, Jang-hee/ABD-3534-2020 | 55360244300; 57201863822; 55890136000; 57196396467; 7501393222; 7403536291; 7501831741; 55633533600; 8558530700 | drcdkim@knu.ac.kr; | KOREAN JOURNAL OF INTERNAL MEDICINE | KOREAN J INTERN MED | 1226-3303 | 2005-6648 | 37 | 3 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 2.4 | 55.9 | 1.18 | 2025-06-25 | 8 | 12 | Omics; Biomarkers; Graft rejection; Kidney transplantation | CELL-MEDIATED REJECTION; MESSENGER-RNA; NONINVASIVE DIAGNOSIS; TRANSPLANT RECIPIENTS; URINARY METABOLOMICS; HLA ANTIBODIES; IDENTIFICATION; TRANSCRIPTOME; ASSOCIATION; PROTEOMICS | Biomarkers; Graft rejection; Kidney transplantation; Omics | Allografts; Biomarkers; Graft Rejection; Humans; Kidney; Prospective Studies; Quality of Life; biological marker; protein tyrosine kinase; biological marker; acute graft rejection; Article; chronic graft rejection; end stage renal disease; genomics; graft rejection; human; immunosuppressive treatment; kidney allograft rejection; kidney transplantation; liquid chromatography-mass spectrometry; mass fragmentography; mass spectrometry; metabolomics; nuclear magnetic resonance spectroscopy; omics; pathophysiology; proteomics; transcriptomics; ubiquitination; allograft; genetics; graft rejection; kidney; prospective study; quality of life | English | 2022 | 2022-05 | 10.3904/kjim.2021.518 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | One Year Follow-Up of COVID-19 Related Symptoms and Patient Quality of Life: A Prospective Cohort Study | Purpose: Globally, concerns have grown regarding the long-term effects of novel coronavirus disease (COVID-19) infection. Therefore, we evaluated the long-term course of persistent symptoms and patient quality of life. Materials and Methods: This prospective cohort study was conducted at a single tertiary university hospital from August 31, 2020 to March 29, 2021 with adult patients followed at 6 and 12 months after acute COVID-19 symptom onset or diagnosis. Clinical characteristics, self-reported symptoms, EuroQol 5 dimension 5 level (EQ5D-5L) index scores, Korean version of the Patient Health Questionnaire-9 (PHQ-9), Korean version of the Posttraumatic Stress Disorder Checklist-5 (PCL-5-K), and Generalized Anxiety Disorder-7 (GAD-7) were investigated. Symptom persistent or non-persistent groups were defined according to persistency of COVID-19 related symptoms or signs after acute COVID-19 infection, respectively. Results: Of all 235 patients, 170 (64.6%) patients were eligible for analysis. The median age was 51 (interquartile range, 37-61) years old, and 102 patients were female (60.0%). After 12 months from acute COVID-19 infection, in total, 83 (48.8%) patients still suffered from COVID-19-related symptoms. The most common symptoms included amnesia (24.1%), insomnia (14.7%), fatigue (13.5%), and anxiety (12.9%). Among the five EQ5D-5L categories, the average value of anxiety or depression was the most predominant. PHQ-9 and PCL-5-K scores were statistically higher in the COVID-19-related symptom persistent group than the non-persistent group (p=0.001). However, GAD-7 scores showed no statistical differences between the two groups (p=0.051). Conclusion: Neuropsychiatric symptoms were the major COVID-19-related symptoms after 12 months from acute COVID-19 infection, reducing quality of life. | Kim, Yoonjung; Kim, Shin-Woo; Chang, Hyun-Ha; Kwon, Ki Tae; Hwang, Soyoon; Bae, Sohyun | Kyungpook Natl Univ, Sch Med, Dept Internal Med, Div Infect Dis, 130 Dongdeok Ro, Daegu 41944, South Korea | ; Hwang, Soyoon/HHM-5762-2022; Kim, Sooyeon/AAA-8521-2022; Kim, Ji Hoon/AAB-4602-2022; Kim, Hanjin/KYP-2633-2024 | 57203160508; 8710731500; 7407521688; 9733850500; 57203160675; 57219699506 | ksw2kms@knu.ac.kr; | YONSEI MEDICAL JOURNAL | YONSEI MED J | 0513-5796 | 1976-2437 | 63 | 6 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 2.4 | 55.9 | 4.94 | 2025-06-25 | 33 | 31 | COVID-19; SARS-CoV-2; persistent symptoms; long-term consequences; long COVID; life quality; health-related quality of life | SEQUELAE | health-related quality of life; life quality; long COVID; long-term consequences; persistent symptoms; SARS-CoV-2; COVID-19 | adult; aged; ageusia; alopecia; amnesia; anorexia; anosmia; anxiety; arthralgia; Article; chill; cognitive defect; cohort analysis; coronavirus disease 2019; coughing; COVID toe; depression; diarrhea; dizziness; dyspnea; European Quality of Life 5 Dimensions questionnaire; fatigue; female; fever; follow up; Generalized Anxiety Disorder-7; globus hystericus; hallucination; headache; heart arrhythmia; heart palpitation; human; insomnia; lifestyle modification; major clinical study; male; mental health; middle aged; myalgia; nausea; obsession; paresthesia; Patient Health Questionnaire 9; physical activity; posttraumatic stress disorder checklist; prospective study; quality of life; rhinorrhea; seizure; Severe acute respiratory syndrome coronavirus 2; skin pruritus; social phobia; sore throat; thorax pain; tinnitus; vomiting | English | 2022 | 2022-06 | 10.3349/ymj.2022.63.6.499 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Optimal blood pressure target in the elderly: rationale and design of the HOW to Optimize eLDerly systolic Blood Pressure (HOWOLD-BP) trial | Background/Aims: The optimal systolic blood pressure (SBP) goal for elderly patients with hypertension, especially to reduce cardiovascular disease (CVD) incidence and improve outcome, is unclear. This study aimed to evaluate the beneficial effects of intensive treatment for hypertension on the incidence of CVD in elderly Korean patients. Methods: The HOW to Optimize eLDerly systolic Blood Pressure (HOWOLD- BP) trial is a multicenter, parallel- design, open-label, randomized controlled trial designed to evaluate whether intensive treatment (SBP = 65 years. For this study, eleven university hospitals in Korea will enroll approximately 3,176 elderly patients with hypertension between 2019 and 2022. Patients will be requested to visit the clinic every 4 months for the first year and every 6 months thereafter for 36 months. Parameters, including clinic and home blood pressure, anthropometric and laboratory findings, and frailty assessments, will be collected according to the standardized protocol. The primary outcome is a composite of CVD (acute coronary syndrome, stroke, and heart failure) incidence and cardiovascular deaths. Results: As of December 2021, 1,655 participants had been enrolled in the study, including 831 patients in the standard group and 824 patients in the intensive group. Conclusions: The HOWOLD- BP trial is the first study performed in Korea to evaluate the beneficial effects of intensive blood pressure treatment on CVD in elderly patients with hypertension. The results of this study will help clarify the appropriate target SBP for this population. | Lee, Dong-Hwa; Lee, Ju-Hee; Kim, So Young; Lee, Hae-Young; Choi, Jung-Yeon; Hong, Youjin; Park, Sue K.; Ryu, Dong Ryeol; Yang, Dong Heon; Hwang, Seok-Jae; Choi, Jung Hyun; Kim, Kye Hun; Lee, Sun Hwa; Joo, Seung Jae; Park, Jae-Hyeong; Kim, Sang-Hyun; Kim, Hack-Lyong; Kim, Kwang-Il; Cho, Myeong-Chan | Chungbuk Natl Univ, Coll Med, Dept Internal Med, 776 1sunhwan Ro, Cheongju 28644, South Korea; Chungbuk Natl Univ Hosp, Dept Cardiol, Cheongju, South Korea; Chungbuk Natl Univ Hosp, Cardiocerebrovasc Ctr, Cheongju, South Korea; Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea; Seoul Natl Univ Bundang Hosp, Dept Internal Med, Seongnam, South Korea; Seoul Natl Univ, Coll Med, Dept Prevent Med, Seoul, South Korea; Seoul Natl Univ, Canc Res Inst, Seoul, South Korea; Seoul Natl Univ, Coll Med, Integrated Major Innovat Med Sci, Seoul, South Korea; Kangwon Natl Univ, Kangwon Natl Univ Hosp, Sch Med, Div Cardiol,Dept Internal Med, Chunchon, South Korea; Kyungpook Natl Univ Hosp, Dept Internal Med, Div Cardiol, Daegu, South Korea; Gyeongsang Natl Univ, Gyeongsang Natl Univ Hosp, Coll Med, Dept Internal Med, Jinju, South Korea; Pusan Natl Univ Hosp, Med Res Inst, Dept Internal Med, Div Cardiol, Busan, South Korea; Chonnam Natl Univ Hosp, Dept Cardiovasc Med, Gwangju, South Korea; Jeonbuk Natl Univ, Jeonbuk Natl Univ Hosp, Sch Med, Div Cardiol,Dept Internal Med, Jeonju, South Korea; Jeju Natl Univ Hosp, Dept Cardiol, Jeju, South Korea; Chungnam Natl Univ, Chungnam Natl Univ Hosp, Coll Med, Div Cardiol,Dept Internal Med, Daejeon, South Korea; Seoul Metropolitan Govt Seoul Natl Univ, Boramae Med Ctr, Dept Internal Med, Div Cardiol, Seoul, South Korea | Lee, Dong-Hwa/P-9788-2018; Park, Jae-Hyeong/AAD-9015-2021; lee, sun hwa/R-1431-2019; Kim, So Young/AET-2590-2022; Kim, Kwang-il/AAP-7315-2021 | 57218663446; 57204073070; 57196226833; 56151235500; 56509684100; 57885302400; 8085325400; 59734016900; 35277423400; 36007319200; 56399550000; 56150430800; 57887827800; 9236504200; 36063048400; 49663680000; 17135448100; 57193847032; 7401727518 | mccho@chungbuk.ac.kr; | KOREAN JOURNAL OF INTERNAL MEDICINE | KOREAN J INTERN MED | 1226-3303 | 2005-6648 | 37 | 5 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 2.4 | 55.9 | 0.53 | 2025-06-25 | 5 | 5 | Randomized controlled trial; Hypertension; Blood pressure; Goals; Aged | Aged; Blood pressure; Goals; Hypertension; Randomized controlled trial | Acute Coronary Syndrome; Aged; Antihypertensive Agents; Blood Pressure; Cardiovascular Diseases; Humans; Hypertension; Risk Factors; angiotensin receptor antagonist; beta adrenergic receptor blocking agent; creatinine; dipeptidyl carboxypeptidase inhibitor; hemoglobin A1c; placebo; antihypertensive agent; acute coronary syndrome; adult; aged; Article; blood pressure; blood pressure monitoring; brain infarction; cardiovascular disease; cardiovascular mortality; cerebrovascular disease; controlled study; creatinine blood level; daily life activity; diastolic blood pressure; dyslipidemia; estimated glomerular filtration rate; heart failure; heart infarction; heart left ventricle ejection fraction; hemodialysis; hospitalization; human; hypertension; hypotension; major clinical study; medication compliance; multicenter study; National Institutes of Health Stroke Scale; outcome assessment; physical activity; quality of life; questionnaire; randomized controlled trial; systolic blood pressure; thyroid disease; Unified Parkinson Disease Rating Scale; university hospital; walking speed; acute coronary syndrome; blood pressure; cardiovascular disease; clinical trial; hypertension; risk factor | English | 2022 | 2022-09 | 10.3904/kjim.2022.067 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Prognostic outcome of treatment modalities for epidermal growth factor receptor-mutated advanced lung cancer | Background/Aims: The treatment of epidermal growth factor receptor (EGFR)-mutated lung cancer cases has shown remarkable development in the past two decades. However, there have been limited studies comparing the prognostic effects of EGFR-tyrosine kinase inhibitor (TKI) and other treatment modalities. Therefore, we compared the survival outcomes of patients treated with EGFR-TKIs versus those treated with other treatment modalities. Methods: Patient data were collected from the Korean National Health Insurance Database, National Health Insurance Service-National Sample Cohort 2002 to 2015, which was released by the Korean National Health Insurance Service in 2015. The lung cancer group included patients (n = 2,003) initially diagnosed with lung cancer between January 2010 and December 2013. The main outcome was all-cause mortality. A Cox proportional hazard regression analysis was used to calculate the relative risk of mortality. Results: Among the newly diagnosed lung cancer cases, 1,004 (50.1%) were included in the analysis. A 15.1-month median survival benefit was observed in the EGFR-TKI group than that of the multimodality therapy group. The risk of mortality was as follows: EGFR-TKI treatment group (n = 142; hazard ratio [HR], 5.29; 95% confidence interval [CI], 3.57 to 7.86) and multimodality therapy group (n = 326; HR, 7.42; 95% CI, 5.19 to 10.63) compared to surgery only (n = 275). Conclusions: Patients with advanced lung cancer harbouring EGFR mutations treated with EGFR-TKIs showed better median survival and lower risk of mortality than those in the multimodality therapy group. In the case of EGFR-mutated advanced lung cancer, there is room for downstaging in the TNM classification. | Jang, Seung Hun; Lee, Dong Yoon; Jeong, Jihyeon; Choi, Won-Il | Hallym Univ, Sacred Heart Hosp, Dept Internal Med, Div Pulm Allergy & Crit Care Med, Anyang, South Korea; Keimyung Univ, Sch Med, Dept Prevent Med, Daegu, South Korea; Kyungpook Natl Univ, Dept Stat, Daegu, South Korea; Hanyang Univ, Myongji Hosp, Coll Med, Dept Internal Med, 55 Hwasu Ro 14beon Gil, Goyang 10475, South Korea | ; Lee, DongYoon/KFR-2934-2024 | 7402219050; 57309281000; 57209972988; 7402516121 | choi_wi@hanmail.net; | KOREAN JOURNAL OF INTERNAL MEDICINE | KOREAN J INTERN MED | 1226-3303 | 2005-6648 | 37 | 4 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 2.4 | 55.9 | 0.11 | 2025-06-25 | 2 | 1 | Epidermal growth factor receptor; Lung neoplasms; Neoplasm staging; Tyrosine kinase | 1ST-LINE TREATMENT; EGFR-MUTATION; OPEN-LABEL; TNM CLASSIFICATION; ADENOCARCINOMA; GEFITINIB; AFATINIB; OSIMERTINIB; ASSOCIATION; GEMCITABINE | Epidermal growth factor receptor; Lung neoplasms; Neoplasm staging; Tyrosine kinase | Carcinoma, Non-Small-Cell Lung; ErbB Receptors; Humans; Lung Neoplasms; Mutation; Prognosis; Protein Kinase Inhibitors; Treatment Outcome; carboplatin; cisplatin; epidermal growth factor receptor; etoposide; irinotecan; topotecan; epidermal growth factor receptor; protein kinase inhibitor; adult; aged; all cause mortality; Article; cancer chemotherapy; cancer prognosis; cancer staging; cohort analysis; comparative study; EGFR gene; female; gene mutation; human; lung cancer; lung surgery; major clinical study; male; median survival time; mortality risk; multimodality cancer therapy; national health insurance; patient coding; South Korea; genetics; lung tumor; mutation; non small cell lung cancer; prognosis; treatment outcome | English | 2022 | 2022-07 | 10.3904/kjim.2021.488 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Solubility and crystallization of ibuprofen in the presence of solvents and antisolvents | The solubility and crystallization behavior of ibuprofen was investigated in the presence of solvents (acetone and ethanol) and antisolvents (water and hydrogen peroxide). The solubility of ibuprofen was determined in the mixtures of acetone+water, acetone+hydrogen peroxide, ethanol+water, and ethanol+hydrogen peroxide. The phase boundaries of these ternary systems were determined as a function of the mixtures' concentration at 27, 35, and 40 degrees C. Based on the solubility data, ibuprofen was crystallized using the antisolvent crystallization technique. It was found that the external shape and internal structure of ibuprofen crystals were nearly independent of solvent and antisolvent, but the size distribution of the resulting particles changed. In the crystallization process, the application of ultrasound induced a significant reduction in particle size and caused severe agglomeration of micronized ibuprofen. This problem was solved by adding an external additive (Tween 80) to the solvent and antisolvent mixtures. | Baek, Seung-Wook; Yeo, Sang-Do | Kyungpook Natl Univ, Dept Chem Engn, Daegu 41566, South Korea; SK Innovat R&D Inst, Expo Ro, Daejeon 34124, South Korea | 57554191100; 7101872251 | syeo@knu.ac.kr; | KOREAN JOURNAL OF CHEMICAL ENGINEERING | KOREAN J CHEM ENG | 0256-1115 | 1975-7220 | 39 | 6 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;ENGINEERING, CHEMICAL | 2022 | 2.7 | 55.9 | 0.07 | 2025-06-25 | 1 | 1 | Antisolvent; Crystallization; Ibuprofen; Solubility; Tween 80 | ULTRASOUND; CRYSTALS | Antisolvent; Crystallization; Ibuprofen; Solubility; Tween 80 | English | 2022 | 2022-06 | 10.1007/s11814-022-1090-7 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | The current status and outcomes of in-hospital P2Y12 receptor inhibitor switching in Korean patients with acute myocardial infarction | Background/Aims: While switching strategies of P2Y12 receptor inhibitors (RIs) have sometimes been used in acute myocardial infarction (AMI) patients, the current status of in-hospital P2Y12RI switching remains unknown. Methods: Overall, 8,476 AMI patients who underwent successful revascularization from Korea Acute Myocardial Infarction Registry-National Institute of Health (KAMIR-NIH) were divided according to in-hospital P2Y12RI strategies, and net adverse cardiovascular events (NACEs), defined as a composite of cardiac death, non-fatal myocardial infarction (MI), stroke, or thrombolysis in myocardial infarction (TIMI) major bleeding during hospitalization were compared. Results: Patients with in-hospital P2Y12RI switching accounted for 16.5%, of which 867 patients were switched from clopidogrel to potent P2Y12RI (C-P) and 532 patients from potent P2Y12RI to clopidogrel (P-C). There were no differences in NACEs among the unchanged clopidogrel, the unchanged potent P2Y12RIs, and the P2Y12RI switching groups. However, compared to the unchanged clopidogrel group, the C-P group had a higher incidence of non-fatal MI, and the P-C group had a higher incidence of TIMI major bleeding. In clinical events of in-hospital P2Y12RI switching, 90.9% of non-fatal MI occurred during pre-switching clopidogrel administration, 60.7% of TIMI major bleeding was related to pre-switching P2Y12RIs, and 71.4% of TIMI major bleeding was related to potent P2Y12RIs. Only 21.6% of the P2Y12RI switching group switched to P2Y12RIs after a loading dose (LD); however, there were no differences in clinical events between patients with and without LD. Conclusions: In-hospital P2Y12RI switching occurred occasionally, but had relatively similar clinical outcomes compared to unchanged P2Y12RIs in Korean AMI patients. Non-fatal MI and bleeding appeared to be mainly related to pre-switching P2Y12RIs. | Park, Keun-Ho; Jeong, Myung Ho; Kim, Hyun Kuk; Ki, Young-Jae; Kim, Sung Soo; Ahn, Youngkeun; Kook, Hyun Yi; Kim, Hyo-Soo; Gwon, Hyeon Cheol; Seung, Ki Bae; Rha, Seung Woon; Chae, Shung Chull; Kim, Chong Jin; Cha, Kwang Soo; Park, Jong Seon; Yoon, Jung Han; Chae, Jei Keon; Joo, Seung Jae; Choi, Dong-Joo; Hur, Seung Ho; Seong, In Whan; Cho, Myeong Chan; Kim, Doo Il; Oh, Seok Kyu; Ahn, Tae Hoon; Hwang, Jin Yong | Chosun Univ Hosp, Dept Internal Med, Div Cardiol, Gwangju, South Korea; Chonnam Natl Univ, Chonnam Natl Univ Hosp, Dept Cardiovasc Med, Med Sch, 42 Jebong Ro, Gwangju 61469, South Korea; Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Heart Vasc & Stroke Inst, Sch Med, Seoul, South Korea; Catholic Univ Korea, Coll Med, Dept Internal Med, Div Cardiol, Seoul, South Korea; Korea Univ, Cardiovasc Ctr, Guro Hosp, Seoul, South Korea; Kyungpook Natl Univ Hosp, Dept Internal Med, Daegu, South Korea; Kyung Hee Univ Hosp Gangdong, Cardiovasc Ctr, Seoul, South Korea; Pusan Natl Univ Hosp, Dept Internal Med, Busan, South Korea; Yeungnam Univ, Dept Internal Med, Div Cardiol, Med Ctr, Daegu, South Korea; Yonsei Univ, Wonju Severance Christian Hosp, Dept Internal Med, Div Cardiol,Wonju Coll Med, Wonju, South Korea; Jeonbuk Natl Univ Hosp, Dept Internal Med, Jeonju, South Korea; Jeju Natl Univ Hosp, Dept Internal Med, Jeju, South Korea; Seoul Natl Univ, Dept Internal Med, Bundang Hosp, Seongnam, South Korea; Keimyung Univ, Dept Internal Med, Div Cardiol, Dongsan Hosp, Daegu, South Korea; Chungnam Natl Univ Hosp, Dept Internal Med, Daejeon, South Korea; Chungbuk Natl Univ Hosp, Dept Internal Med, Cheongju, South Korea; Inje Univ, Dept Internal Med, Div Cardiol, Haeundae Paik Hosp, Busan, South Korea; Wonkwang Univ Hosp, Dept Internal Med, Div Cardiol, Iksan, South Korea; Gachon Univ, Dept Internal Med, Div Cardiol, Gil Med Ctr, Incheon, South Korea; Gyeongsang Natl Univ Hosp, Dept Internal Med, Jinju, South Korea | Jeong, Young-Hoon/F-3476-2015; 안, 태훈/GON-9067-2022; Rha, Seung-Woon/AGE-5810-2022; Han, Jung-Kyu/JGE-4952-2023; Kim, Jin Sug/AAY-6890-2021; Kim, Hyo/J-2753-2012; Kook, Hyun-Yi/JBS-3560-2023; Han, Jae-Young/AAV-1100-2021; SungSoo, Kim/Q-3672-2016 | 7408064075; 56485157500; 57206210646; 48662359900; 57015155300; 56937721300; 57560525400; 33567809200; 6603262426; 7003964208; 8569030400; 7101962036; 35229511500; 7102837700; 15763054600; 35760728900; 26029709000; 9236504200; 57560964600; 34570274500; 35254371300; 57202711833; 8635545900; 24734336000; 57222278496; 55892914700 | myungho@chollian.net; | KOREAN JOURNAL OF INTERNAL MEDICINE | KOREAN J INTERN MED | 1226-3303 | 2005-6648 | 37 | 2 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 2.4 | 55.9 | 0.11 | 2025-06-25 | 1 | 1 | Myocardial infarction; Platelet aggregation inhibitors; Hemorrhage | PERCUTANEOUS CORONARY INTERVENTION; CLINICAL-OUTCOMES; DE-ESCALATION; CLOPIDOGREL; PRASUGREL; TICAGRELOR; MULTICENTER; THERAPY | Hemorrhage; Myocardial infarction; Platelet aggregation inhibitors | Clopidogrel; Hemorrhage; Hospitals; Humans; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Treatment Outcome; antithrombocytic agent; clopidogrel; prasugrel; purinergic P2Y12 receptor; ticagrelor; antithrombocytic agent; clopidogrel; prasugrel; purinergic P2Y receptor antagonist; acute heart infarction; aged; Article; bleeding; blood clot lysis; clinical outcome; cohort analysis; drug potency; drug substitution; drug withdrawal; female; heart death; hospitalization; human; incidence; major clinical study; male; stent thrombosis; adverse event; bleeding; heart infarction; hospital; percutaneous coronary intervention; treatment outcome | English | 2022 | 2022-03 | 10.3904/kjim.2021.101 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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