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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Effects of oridonin on sperm function and the PI3K/PDK1/AKT signaling pathway: Implications for reproductive toxicity | Oridonin, a natural terpenoid isolated from the leaves of Isodon rubescens (Hemsley) H.Hara, is widely used in oriental medicine for its anticancer properties across various cancer types. Despite its prevalent use, the toxic effects of oridonin on male reproduction, particularly its impact on sperm functions and the mechanisms involved, are not well understood. This study aimed to explore the effects and underlying mechanisms of oridonin on sperm functions. We initially treated Duroc boar spermatozoa with varying concentrations of oridonin (0, 5, 50, 75, 100, and 150 mu M) and incubated them to induce capacitation. We then assessed cell viability and several sperm functions, including sperm motility and motion kinematics, capacitation status, and ATP levels. We also analyzed the expression levels of proteins associated with the phosphatidylinositol 3-kinase (PI3K)/phosphoinositide-dependent kinase-1 (PDK1)/protein kinase B (AKT) signaling pathway and phosphotyrosine proteins. Our results indicate that oridonin adversely affects most sperm functions in a dose-dependent manner. We observed significant decreases in AKT, p-AKT (Thr308), phosphatase and tensin homolog (PTEN), p-PDK1, and pPI3K levels following oridonin treatment, alongside an abnormal increase in phosphotyrosine proteins. These findings suggest that oridonin may disrupt normal levels of tyrosine-phosphorylated proteins by inhibiting the PI3K/PDK1/AKT signaling pathway, which is crucial for cell proliferation, metabolism, and apoptosis, thus potentially harming sperm functions. Consequently, we recommend considering the reproductive toxicity of oridonin when using it as a therapeutic agent. | Hwang, Ju-Mi; Lee, Woo-Jin; Jo, Jae-Hwan; Uwamahoro, Claudine; Jang, Seung-Ik; Jung, Eun-Ju; Bae, Jeong-Won; Kim, Dae-Hyun; Yi, Jun Koo; Ha, Jae Jung; Oh, Dong Yep; Kwon, Woo-Sung | Kyungpook Natl Univ, Dept Anim Sci & Biotechnol, Sangju 37224, Gyeongsangbuk D, South Korea; Chonnam Natl Univ, Dept Anim Sci, Gwangju 61186, South Korea; Hankyong Natl Univ, Sch Anim Life Convergence Sci, Anseong 17579, South Korea; Gyeongbuk Livestock Res Inst, Yeongju 36052, South Korea; Kyungpook Natl Univ, Res Inst Innovat Anim Sci, Sangju 37224, South Korea | Kwon, Woo-Sung/J-6731-2019; Bae, Jeong-Won/AAH-4932-2021 | 57217871526; 57377138800; 58346379700; 58844996200; 58346379800; 57377289200; 57211231093; 57211228843; 56182537200; 55848402300; 42861900800; 54383715800 | wskwon@knu.ac.kr; | REPRODUCTIVE TOXICOLOGY | REPROD TOXICOL | 0890-6238 | 1873-1708 | 128 | SCIE | REPRODUCTIVE BIOLOGY;TOXICOLOGY | 2024 | 2.8 | 39.3 | 0 | 2025-05-07 | 0 | 0 | Oridonin; Reproductive toxicity; Sperm functions; PI3K/PDK1/AKT signaling pathway | PHOSPHOINOSITIDE 3-KINASE; TUMOR-SUPPRESSOR; AKT; MOTILITY; CAPACITATION; SPERMATOZOA; PTEN/MMAC1; MECHANISM; APOPTOSIS; GROWTH | Oridonin; PI3K/PDK1/AKT signaling pathway; Reproductive toxicity; Sperm functions | Adenosine Triphosphate; Animals; Cell Survival; Diterpenes, Kaurane; Male; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Signal Transduction; Sperm Capacitation; Sperm Motility; Spermatozoa; Swine; 4 [5 (4 methyl 1 piperazinyl)[2,5' bi 1h benzimidazol] 2' yl]phenol; adenosine triphosphate; oridonin; phosphatidylinositol 3 kinase; phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase; phosphoinositide dependent protein kinase 1; phosphotyrosine; protein kinase B; kaurane derivative; oridonin; phosphatidylinositol 3 kinase; protein kinase B; pyruvate dehydrogenase kinase; animal cell; apoptosis; Article; cell metabolism; cell proliferation; cell viability; clinical assessment; controlled study; drug effect; Duroc pig; incubation time; kinematics; male; nonhuman; PI3K PDK1 AKT signaling pathway; protein expression; protein phosphorylation; reproductive toxicity; signal transduction; sperm capacitation; sperm function; spermatozoon; spermatozoon motility; Western blotting; animal; cell survival; drug effect; metabolism; pig; spermatozoon; spermatozoon motility | English | 2024 | 2024-09 | 10.1016/j.reprotox.2024.108659 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Ethylene oxide suppresses boar sperm function during capacitation | Ethylene oxide (E.O) is an epoxide compound, and it has been utilized as a sterilizer or production of ether compounds in several industries. Although the toxic effects of E.O on bacteria and mammals have been reported, its effects on male reproductive toxicity during sperm capacitation are not fully understood. Therefore, this study was designed to evaluate the effects of E.O exposure during sperm capacitation. Boar spermatozoa were treated with various E.O concentrations (0, 0.1, 1, 10, and 100 mu & Mcy;). After exposure, sperm motility, motion kinematics, capacitation status, intracellular ATP levels, cell viability, expression levels of protein kinase A (PKA) activation, and tyrosine phosphorylation were evaluated. Results revealed that E.O exposure significantly decreased sperm motility, motion kinematics, and intracellular ATP levels but significantly increased the capacitated spermatozoa. In addition, the PKA activation and tyrosine phosphorylation were abnormally changed. According to our results, E.O may cause toxic effects on sperm function during capacitation, which induces male reproductive toxicity. Consequently, we suggest that male reproductive toxicity should be considered when using E.O. | Jo, Jae-Hwan; Uwamahoro, Claudine; Jang, Seung-Ik; Jung, Eun-Ju; Lee, Woo-Jin; Bae, Jeong-Won; Kim, Dae-Hyun; Yi, Jun Koo; Oh, Dong Yep; Ha, Jae Jung; Kwon, Woo-Sung | Kyungpook Natl Univ, Dept Anim Sci & Biotechnol, Sangju 37224, Gyeongsangbug D, South Korea; Chonnam Natl Univ, Dept Anim Sci, Gwangju 61186, South Korea; Hankyong Natl Univ, Sch Anim Life Convergence Sci, Anseong 17579, South Korea; Gyeongbuk Livestock Res Inst, Yeongju 36052, South Korea; Kyungpook Natl Univ, Res Inst Innovat Anim Sci, Sangju 37224, Gyeongsangbug D, South Korea | Kwon, Woo-Sung/J-6731-2019; Bae, Jeong-Won/AAH-4932-2021 | 58346379700; 58844996200; 58346379800; 57377289200; 57377138800; 57211231093; 57211228843; 56182537200; 42861900800; 55848402300; 54383715800 | hjjggo@korea.kr;wskwon@knu.ac.kr; | REPRODUCTIVE TOXICOLOGY | REPROD TOXICOL | 0890-6238 | 1873-1708 | 129 | SCIE | REPRODUCTIVE BIOLOGY;TOXICOLOGY | 2024 | 2.8 | 39.3 | 0.51 | 2025-05-07 | 1 | 1 | Ethylene oxide; Sperm function; Capacitation; Male reproductive toxicity | EPITHELIAL-CELLS; HYPERACTIVATION; SUSCEPTIBILITY; STERILIZATION; SPERMATOZOA; INHALATION; RISK | Capacitation; Ethylene oxide; Male reproductive toxicity; Sperm function | Adenosine Triphosphate; Animals; Cell Survival; Cyclic AMP-Dependent Protein Kinases; Male; Phosphorylation; Sperm Capacitation; Sperm Motility; Spermatozoa; Swine; Tyrosine; adenosine triphosphate; cyclic AMP dependent protein kinase; ethylene oxide; tyrosine; adenosine triphosphate; cyclic AMP dependent protein kinase; tyrosine; animal cell; animal experiment; Article; cell level; cell viability; controlled study; enzyme activation; enzyme activity; exposure; kinematics; male; male genital system; nonhuman; pig; protein expression level; protein phosphorylation; reproductive toxicity; sperm capacitation; sperm function; spermatozoon; spermatozoon motility; toxic concentration; animal; cell survival; drug effect; metabolism; phosphorylation; physiology; pig; spermatozoon; spermatozoon motility | English | 2024 | 2024-10 | 10.1016/j.reprotox.2024.108678 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Exploring Potential Intermediates in the Cross-Species Transmission of Influenza A Virus to Humans | The influenza A virus (IAV) has been a major cause of several pandemics, underscoring the importance of elucidating its transmission dynamics. This review investigates potential intermediate hosts in the cross-species transmission of IAV to humans, focusing on the factors that facilitate zoonotic events. We evaluate the roles of various animal hosts, including pigs, galliformes, companion animals, minks, marine mammals, and other animals, in the spread of IAV to humans. | Lee, Chung-Young | Kyungpook Natl Univ, Dept Microbiol, Sch Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Untreatable Infect Dis Inst, Daegu 41944, South Korea | 57195422071 | cylee87@knu.ac.kr; | VIRUSES-BASEL | VIRUSES-BASEL | 1999-4915 | 16 | 7 | SCIE | VIROLOGY | 2024 | 3.5 | 39.3 | 1.38 | 2025-05-07 | 6 | 9 | influenza A virus; cross-species transmission; zoonosis; intermediate host; pandemic | RECEPTOR-BINDING PROPERTIES; SINGLE AMINO-ACID; MOLECULAR CHARACTERIZATION; NEURAMINIDASE ACTIVITIES; VIRAL REPLICATION; HUMAN INFECTION; PANDEMIC H1N1; HONG-KONG; H5 HA; HEMAGGLUTININ | cross-species transmission; influenza A virus; intermediate host; pandemic; zoonosis | Animals; Humans; Influenza A virus; Influenza, Human; Orthomyxoviridae Infections; Swine; Viral Zoonoses; Zoonoses; epidemiology; etiology; Galliformes; human; Influenza A virus; intermediate host; marine mammal; Neovison vison; nonhuman; pandemic; pet animal; pig; review; zoonosis; zoonotic transmission; animal; genetics; influenza; orthomyxovirus infection; physiology; veterinary medicine; viral zoonosis; virology; zoonosis | English | 2024 | 2024-07 | 10.3390/v16071129 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Perfluorooctanoic acid suppresses sperm functions via abnormal Protein Kinase B activation during capacitation | Perfluorooctanoic acid (PFOA) is a perfluorinated compound, a synthesized chemical, and has been used in several industrial products for more than 70 years. Although PFOA is known to exert toxic effects in normal cells, there is no detailed information on its reproductive toxicity and its effects on sperm functions related to protein kinase B (AKT). Therefore, this study was conducted to explore the effects of PFOA on sperm functions via AKT. Boar spermatozoa were incubated with different concentrations of PFOA (0, 0.1, 1, 10, and 100 mu M) to induce capacitation. Sperm functions (sperm motility, motion kinematic parameters, capacitation status, cell viability, and intracellular ATP levels) were evaluated. In addition, the expression levels of AKT, phospho-AKT, phosphoPKA, and tyrosine phosphorylated proteins were evaluated by western blotting. Results showed significant decreases in sperm motility and motion kinematic parameters. PFOA treatment significant suppressed spermatozoa capacitation and intracellular ATP levels. Furthermore, it significantly decreased the levels of phospho-PKA and tyrosine phosphorylated proteins. The levels of AKT phosphorylation at Thr308 and Ser473 also significantly decreased. These findings suggest that PFOA diminishes sperm functions during capacitation and induces unnatural phosphorylation in AKT, leading to reproductive toxicity. Therefore, people should be aware of reproductive toxicity when using PFOA. | Jang, Seung-Ik; Jo, Jae-Hwan; Jung, Eun-Ju; Lee, Woo-Jin; Hwang, Ju-Mi; Bae, Jeong-Won; Shin, Sangsu; Lee, Sang In; Kim, Myoung Ok; Kwon, Woo-Sung | Kyungpook Natl Univ, Dept Anim Sci & Biotechnol, Sangju 37224, Gyeongsangbug D, South Korea; Kyungpook Natl Univ, Dept Anim Biotechnol, Sangju 37224, Gyeongsangbug D, South Korea; Kyungpook Natl Univ, Res Inst Innovat Anim Sci, Sangju 37224, Gyeongsangbug D, South Korea | Kwon, Woo-Sung/J-6731-2019; Bae, Jeong-Won/AAH-4932-2021 | 58346379800; 58346379700; 57377289200; 57377138800; 57217871526; 57211231093; 55490360000; 57203597336; 8934745900; 54383715800 | wskwon@knu.ac.kr; | REPRODUCTIVE TOXICOLOGY | REPROD TOXICOL | 0890-6238 | 1873-1708 | 123 | SCIE | REPRODUCTIVE BIOLOGY;TOXICOLOGY | 2024 | 2.8 | 39.3 | 1.7 | 2025-04-16 | 3 | 3 | Perfluorooctanoic acid; Boar spermatozoa; Reproductive toxicity; Sperm functions; Capacitation | SIGNALING PATHWAY; OXIDATIVE STRESS; DNA-DAMAGE; MOTILITY; PERFLUOROALKYL; PFOA; SPERMATOZOA; SUBSTANCES; SULFONATE; INSIGHT | Boar spermatozoa; Capacitation; Perfluorooctanoic acid; Reproductive toxicity; Sperm functions | Adenosine Triphosphate; Animals; Caprylates; Fluorocarbons; Humans; Male; Phosphorylation; Proto-Oncogene Proteins c-akt; Semen; Sperm Capacitation; Sperm Motility; Spermatozoa; Swine; Tyrosine; adenosine triphosphate; perfluorooctanoic acid; phosphoserine; phosphotyrosine; protein kinase B; adenosine triphosphate; fluorocarbon; octanoic acid derivative; perfluorooctanoic acid; protein kinase B; tyrosine; animal cell; Article; cell viability; concentration (parameter); controlled study; male; nonhuman; protein defect; protein expression level; protein phosphorylation; reproductive toxicity; sperm function; spermatozoon; spermatozoon maturation; spermatozoon motility; Western blotting; animal; human; metabolism; phosphorylation; pig; sperm; sperm capacitation | English | 2024 | 2024-01 | 10.1016/j.reprotox.2023.108528 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Role of Rab proteins in PFOA-induced changes in boar sperm motility and capacitation | Perfluorooctanoic acid (PFOA), a pervasive environmental contaminant, elicits adverse effects on sperm functions, including sperm motility and capacitation status. However, the specific mechanisms by which PFOA disrupts sperm functions during capacitation remain poorly elucidated. Therefore, this study aimed to investigate the molecular mechanisms underlying the PFOA-induced inhibition of sperm motility and capacitation in boar spermatozoa by focusing on Ras-related (Rab) proteins, which regulate membrane trafficking and play key roles in male sperm development, acrosome formation, and the acrosome reaction. Results showed significant reductions in sperm motility and various kinematic parameters following PFOA exposure. Correlation analysis revealed that Rab14 was positively correlated with dance mean (DNM) and negatively correlated with wobble (WOB), indicating that PFOA might affect sperm motility through Rab14 and potentially lead to reduced pregnancy rates. Differences in Rab25 were positively correlated with differences in total motility (MOT), progressive motility (PRG), linearity (LIN), and mean angular displacement (MAD), suggesting that PFOA might influence sperm motility by altering Rab25. Differences in Rab34 were positively correlated with differences in acrosome-reacted spermatozoa, implicating its role in the acrosome reaction. These findings provided insights into the molecular mechanism of PFOA-induced reproductive toxicity and highlighted the function of Rab proteins as biomarkers for the assessment of the effects of similar environmental toxins on male fertility. | Jang, Seung-Ik; Jo, Jae-Hwan; Uwamahoro, Claudine; Jung, Eun-Ju; Lee, Woo-Jin; Bae, Jeong-Won; Shin, Sangsu; Lee, Sang In; Kim, Myoung Ok; Moon, Joonho; Kwon, Woo-Sung | Kyungpook Natl Univ, Dept Anim Sci & Biotechnol, Sangju 37224, Gyeongsangbuk D, South Korea; Kyungpook Natl Univ, Res Inst Innovat Anim Sci, Sangju 37224, Gyeongsangbuk D, South Korea; Seoul Natl Univ Hosp, Seoul 03080, South Korea | Bae, Jeong-Won/AAH-4932-2021; Kwon, Woo-Sung/J-6731-2019; Moon, Joonho/KFQ-2464-2024 | 58346379800; 58346379700; 58844996200; 57377289200; 57377138800; 57211231093; 55490360000; 57203597336; 8934745900; 56539183000; 54383715800 | moonjh1982@gmail.com;wskwon@knu.ac.kr; | REPRODUCTIVE TOXICOLOGY | REPROD TOXICOL | 0890-6238 | 1873-1708 | 130 | SCIE | REPRODUCTIVE BIOLOGY;TOXICOLOGY | 2024 | 2.8 | 39.3 | 0 | 2025-05-07 | 1 | 1 | Perfluorooctanoic acid; Rab protein; Sperm motility; Capacitation; Biomarker | PERFLUOROOCTANOIC ACID; IN-VIVO; PERFLUOROALKYL; GTPASE; SUBSTANCES; MECHANISMS; SULFONATE; DYNAMICS; ACROSOME; CELLS | Biomarker; Capacitation; Perfluorooctanoic acid; Rab protein; Sperm motility | Animals; Caprylates; Environmental Pollutants; Fluorocarbons; Male; rab GTP-Binding Proteins; Sperm Capacitation; Sperm Motility; Spermatozoa; Swine; biological marker; perfluorooctanoic acid; Rab protein; Rab14 protein; Rab25 protein; Rab34 protein; unclassified drug; fluorocarbon; octanoic acid; perfluorooctanoic acid; Rab protein; acrosome; acrosome formation; acrosome reaction; animal cell; animal experiment; Article; cell maturation; cell membrane transport; clinical significance; controlled study; correlation analysis; kinematics; male; male fertility; molecular pathology; nonhuman; pig; pregnancy rate; protein function; protein modification; regulatory mechanism; reproductive toxicity; sperm capacitation; spermatozoon motility; animal; drug effect; genetics; metabolism; pollutant; spermatozoon; toxicity | English | 2024 | 2024-12 | 10.1016/j.reprotox.2024.108745 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Enhancing landfill gas bio-desulfurization: operational insights and microbial dynamics from the Daegu Bangcheon-ri Sanitary Landfill | This study evaluates the efficacy of the Thiopaq bio-desulfurization system at the Daegu Bangcheon-ri Sanitary Landfill in Korea over 1 year focusing on operational insights and microbial dynamics. The system employs sulfur-oxidizing bacteria (SOBs) to convert hydrogen sulfide (H2S) in landfill gas (LFG) into elemental sulfur. Key findings include maintaining over 96% H2S removal efficiency despite operational challenges such as sulfur clogging and foam formation. Significant microbial community shifts were observed, with Thioalkalibacter halophilus remaining robust, Alkalilimnicola ehrlichii declining, and Halothiobacillus kellyi becoming more prominent, especially during new well installations with high thiol (methanethiol) concentrations. Scanning electron microscopy revealed distinct morphological characteristics of bio-sulfur under varying conditions contributing to process optimization. Our results underscore the necessity for continuous monitoring and adaptive management of microbial populations and system parameters to effectively handle fluctuating LFG compositions and operational conditions. This study provides substantial guidance for enhancing LFG quality and bio-sulfur production in large-scale landfills. | Cho, Eunsue; You, Young-Hyun; Back, Chang-Gi; Hong, Ji Won | Daesung Ecoenergy, Daegu, South Korea; Kyungpook Natl Univ, Dept Hydrogen & Renewable Energy, Daegu, South Korea; Natl Inst Biol Resources, Species Divers Res Div, Incheon, South Korea; Dankook Univ, Dept Environm Hort & Landscape Architecture, Environm Hort, Cheonan, South Korea; Kyungpook Natl Univ, Adv Bioresource Res Ctr, Daegu, South Korea | 59308999200; 53868615500; 36144957400; 57201579963 | jwhong@knu.ac.kr; | FRONTIERS IN ENVIRONMENTAL SCIENCE | FRONT ENV SCI-SWITZ | 2296-665X | 12 | SCIE | ENVIRONMENTAL SCIENCES | 2024 | 3.7 | 39.4 | 0 | 2025-05-07 | 0 | 0 | landfill gas management; sulfur-oxidizing bacteria; biological desulfurization; hydrogen sulfide; sulfur compounds | HYDROGEN-SULFIDE; REMOVAL; CONSTRUCTION; PERFORMANCE; EFFICIENCY; THIOLS | biological desulfurization; hydrogen sulfide; landfill gas management; sulfur compounds; sulfur-oxidizing bacteria | English | 2024 | 2024-08-19 | 10.3389/fenvs.2024.1421510 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Review | Exosomes in Bone Cancer: Unveiling their Vital Role in Diagnosis, Prognosis, and Therapeutic Advancements | Bone cancer among adolescents and children exhibits varying survival outcomes based on disease state. While localized bone cancer cases have a survival rate exceeding 70%, metastatic, refractory, and recurrent forms are associated with significantly poorer prognoses. Initially believed to be mere vehicles for cellular waste disposal, exosomes are now recognized as extracellular vesicles facilitating intercellular communication. These vesicles influence cellular behaviors by transporting various biomolecules, such as proteins, DNA, RNA, and lipids, among cells. The role of exosomes in regulating the progression of bone cancer is increasingly evident, impacting critical processes like tumorigenesis, proliferation, metastasis, angiogenesis, immune evasion, and drug resistance. Current research underscores the substantial potential of exosomes in promoting the progression and development of bone cancer. This review delves into the complex process of exosome biogenesis, the variety of cell -derived exosome sources, and their applications in drug delivery and therapeutics. It also examines ongoing clinical trials focused on exosome cargo levels and discusses the challenges and future directions in exosome research. Unlike costly and invasive traditional diagnostic methods, exosomal biomarkers offer a non-invasive, cost-effective, and readily accessible routine screening through simple fluid collection that aims to inspire researchers to investigate the potential of exosomes for cancer theragnostic. Through comprehensive exploration of these areas, the review seeks to enhance understanding and foster innovative solutions to cancer biology in the near future. | Ghosh, Subhrojyoti; Mahajan, Atharva Anand; Dey, Anuvab; Rajendran, Ramya Lakshmi; Chowdhury, Ankita; Sen, Sushmita; Paul, Subhobrata; Majhi, Sourav; Hong, Chae Moon; Gangadaran, Prakash; Ahn, Byeong-Cheol; Krishnan, Anand | Indian Inst Technol Madras, Dept Biotechnol, Chennai 600036, Tamil Nadu, India; Tata Mem Hosp, Adv Ctr Treatment Res & Educ Canc, Mumbai 410210, Maharashtra, India; Indian Inst Technol Guwahati, Dept Biosci & Bioengn, North Guwahati 781039, Assam, India; Kyungpook Natl Univ, Sch Med, Dept Nucl Med, Daegu 41944, South Korea; Indian Inst Technol, Dept Biochem Engn & Biotechnol, Delhi 110016, India; Univ Free State, Fac Hlth Sci, Sch Pathol, Dept Chem Pathol, ZA-9300 Bloemfontein, South Africa; Kyungpook Natl Univ Hosp, Dept Nucl Med, Daegu 41404, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, FOUR KNU Convergence Educ Program Biomed Sci Creat, Daegu 41944, South Korea | ; Rajendran, Ramya/AAV-6338-2021; DEY, ANUVAB/HSI-3094-2023; Gangadaran, Prakash/AAV-3102-2021; Krishnan, Anand/C-5178-2015; Ghosh, Subhrojyoti/KDN-2006-2024 | 58035427200; 58653487800; 57225769107; 57195318729; 58665538700; 59223313900; 59223493200; 59223580300; 37050876700; 54393130400; 7202791511; 57488883300 | prakashg@knu.ac.kr;abc2000@knu.ac.kr;Krishnana1@ufs.ac.za; | JOURNAL OF CANCER | J CANCER | 1837-9664 | 15 | 13 | SCIE | ONCOLOGY | 2024 | 3.2 | 39.4 | 0.28 | 2025-05-07 | 1 | 1 | Exosomes; Bone cancer; Tumor microenvironment; Biomarkers; Liquid biopsy; Precision medicine; Extracellular vesicles | OSTEOSARCOMA; CELLS; ANGIOGENESIS; MICROVESICLES; EXPRESSION; NANOTECHNOLOGY; BIOGENESIS; ACTIVATION; RESISTANCE; BIOMARKERS | Biomarkers; Bone cancer; Exosomes; Extracellular vesicles; Liquid biopsy; Precision medicine; Tumor microenvironment | biological marker; DNA; angiogenesis; biogenesis; bone cancer; carcinogenesis; cell function; diagnosis; drug delivery system; exosome; human; immune evasion; liquid biopsy; neoplastic cell transformation; personalized medicine; pharmaceutics; review; survival rate; tumor microenvironment; waste disposal | English | 2024 | 2024 | 10.7150/jca.95709 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Imatinib inhibits oral squamous cell carcinoma by suppressing the PI3K/AKT/mTOR signaling pathway | Oral squamous cell carcinoma (OSCC) is a prevalent oral and maxillofacial cancer with high mortality as OSCC cells readily invade tissues and metastasize to cervical lymph nodes. Although imatinib exhibits potential anticancer and remarkable clinical activities that therapeutically affect several cancer types, its specific impact on OSCC has yet to be fully explored. Therefore, this study investigated the potential anticancer effect of imatinib on OSCC cells and the underlying mechanisms. The Cell Counting Kit-8 was used to determine the impact of imatinib on cell viability. Then, morphological cell proliferation analysis was conducted to examine how imatinib impacted OSCC cell growth. Moreover, OSCC cell migration was determined through wound-healing assays, and colony formation abilities were investigated through the soft agar assay. Lastly, the effect of imatinib on OSCC cell apoptosis was verified with flow cytometry, and its inhibitory mechanism was confirmed through Western blot. Our results demonstrate that imatinib effectively inhibited OSCC cell proliferation and significantly curtailed OSCC cell viability in a time- and concentration-dependent manner. Furthermore, imatinib suppressed migration and colony formation while promoting OSCC cell apoptosis by enhancing p53, Bax, and PARP expression levels and reducing Bcl-2 expression. Imatinib also inhibited the PI3K/AKT/mTOR signaling pathway and induced OSCC cell apoptosis, demonstrating the potential of imatinib as a treatment for oral cancer. | Ma, Lei; Huang, Ke; Zhang, Haibo; Kim, Eungyung; Kim, Hyeonjin; Liu, Zhibin; Kim, Chae Yeon; Park, Kanghyun; Raza, Muhammad Atif; Kim, Kirim; Yi, Junkoo; Sung, Yonghun; Ryoo, Zae Young; Kim, Yong-Gun; Kim, Myoung Ok | Kyungpook Natl Univ, Res Ctr Horse Ind, Dept Anim Sci & Biotechnol, Sangju 37224, Gyeongsangbuk D, South Korea; Henan Univ Chinese Med, Coll Pharm, Zhengzhou 450046, Peoples R China; Kyungpook Natl Univ, Dept Dent Hyg, Sangju, South Korea; Hankyong Natl Univ, Sch Anim Life Convergence Sci, Anseong 17579, South Korea; Daegu Gyeongbuk Med Innovat Fdn DGMIF, Preclin Res Ctr, Daegu 41061, South Korea; Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat BioRes Grp, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Periodontol, Daegu, South Korea | Yi, Junkoo/JBR-8507-2023; RYOO, ZAEYOUNG/AAQ-1573-2020; Kim, Yong-Gun/JPQ-3309-2023; liu, zhibin/D-5655-2014 | 57217867673; 58639636600; 57221648126; 57217871658; 57343180400; 58640210100; 57966906800; 58530860300; 58291484800; 35793746200; 56182537200; 58903739800; 16937104900; 55622694400; 8934745900 | ok4325@knu.ac.kr; | JOURNAL OF CANCER | J CANCER | 1837-9664 | 15 | 3 | SCIE | ONCOLOGY | 2024 | 3.2 | 39.4 | 2.1 | 2025-04-16 | 8 | 9 | imatinib; oral squamous cell carcinoma; proliferation; viability; PI3K/AKT/mTOR signaling pathway | CANCER | imatinib; oral squamous cell carcinoma; PI3K/AKT/mTOR signaling pathway; proliferation; viability | beta actin; imatinib; mammalian target of rapamycin; nerve cell adhesion molecule; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase; phosphatidylinositol 3 kinase; protein Bax; protein bcl 2; protein kinase B; protein p53; uvomorulin; antineoplastic activity; apoptosis; Article; cell culture; cell cycle; cell growth; cell migration; cell proliferation; cell viability; colony formation; colony forming unit; controlled study; drug effect; drug mechanism; fibroblast; flow cytometry; human; human cell; immunohistochemistry; mouth squamous cell carcinoma; mTOR signaling; Pi3K/Akt signaling; protein expression; protein expression level; transwell assay; Western blotting; wound healing assay | English | 2024 | 2024 | 10.7150/jca.88555 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Molecular phylogenetic reconstruction improves the taxonomic understanding of Indian Dipcadi (Asparagaceae) and reveals a new species from the bank of Hiranyakeshi River, Maharashtra, India | Dipcadi (Scilloideae: Asparagaceae) is a genus of bulbous monocots with approximately 40 species, of which 13 occur in India. Species delimitation within the genus has been troublesome hindering a comprehensive phylogenetic analysis. The most recent phylogeny of the subfamily Ornithogaloideae included six species of Dipcadi only from Africa. Here, we reconstructed the phylogeny of Ornithogaloideae including 23 accessions comprising 13 recognized taxa (11 species and two varieties) of Indian Dipcadi. The phylogenetic analyses were based on nucleotide sequences of three plastid regions (rbcL, matK and trnL-F spacer) and one nuclear region (ITS). Pseudogaltonia clavata exhibited sister relationship to Dipcadi. Our combined nuclear + plastid dataset analyses revealed a monophyletic Dipcadi with five clades, Clade I-V. Clade I, II and III included mainly Indian species whereas Clade V included mostly African species. Clade IV comprised D. serotinum. Clade I included nine taxa including our newly described species, D. mukaianum. The new species was phylogenetically placed with D. erythraeum, D. saxorum and D. ursulae. Morphologically, the species resembled D. montanum and D. ursulae but differed in characters such as tepal cohesion, number of ovules per locule and foul-smelling flowers. Clade II and III included 11 and six taxa, respectively. D. erythraeum which has a native range from Egypt to western India was found in Clades I and V. The widespread Dipcadi species, viz. D. erythraeum and D. serotinum showed polyphyly however, the monophyly of Dipcadi is established. Our studies suggest that additional molecular markers (plastid as well as nuclear) should be tested for their taxonomy utility. Further work on the historical biogeography of Dipcadi on the subfamily Ornithogaloideae with more genetic data will yield insights how aridification of the landscape would have shaped the evolution of the geographical clades. | Shelke, P. E.; Tamboli, A. S.; Surveswaran, S.; Yadav, S. R.; Choo, Y. -s.; Pak, J. H.; Lekhak, M. M. | Shivaji Univ, Dept Bot, Angiosperm Taxon Lab, Kolhapur 416004, Maharashtra, India; Kyungpook Natl Univ, Res Inst Dok Do & Ulleung Do Isl, 80 Daehak Ro, Daegu 41566, South Korea; Univ Hyderabad, Sch Life Sci, Dept Plant Sci, Hyderabad 500046, Telangana, India; Kyungpook Natl Univ, Sch Life Sci, Dept Biol, 80 Daehak Ro, Daegu 41566, South Korea | Surveswaran, Siddharthan/AAO-8560-2021; Tamboli, Asif/HJB-2803-2022; Lekhak, Manoj/AAP-5079-2020 | 57966621800; 56974034100; 15766021500; 57203296258; 59400334100; 7102232932; 35573958700 | mml_botany@unishivaji.ac.in;botany@unishivaji.ac.in; | JOURNAL OF PLANT RESEARCH | J PLANT RES | 0918-9440 | 1618-0860 | 137 | 5 | SCIE | PLANT SCIENCES | 2024 | 2.3 | 39.4 | 0 | 2025-05-07 | 3 | 3 | cpDNA; Dipcadi; ITS; Monocots; Scilloideae; Taxonomy | IQ-TREE; SEQUENCE; CLASSIFICATION; AMPLIFICATION; PRIMERS; REGIONS; RBCL | cpDNA; Dipcadi; ITS; Monocots; Scilloideae; Taxonomy | Asparagaceae; DNA, Plant; India; Phylogeny; Plastids; Sequence Analysis, DNA; plant DNA; Asparagaceae; classification; DNA sequencing; genetics; India; phylogeny; plastid | English | 2024 | 2024-09 | 10.1007/s10265-024-01558-9 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Quantitative evaluation of uncertainty and interpretability in machine learning-based landslide susceptibility mapping through feature selection and explainable AI | Landslide susceptibility mapping (LSM) is essential for determining risk regions and guiding mitigation strategies. Machine learning (ML) techniques have been broadly utilized, but the uncertainty and interpretability of these models have not been well-studied. This study conducted a comparative analysis and uncertainty assessment of five ML algorithms-Random Forest (RF), Light Gradient-Boosting Machine (LGB), Extreme Gradient Boosting (XGB), K-Nearest Neighbor (KNN), and Support Vector Machine (SVM)-for LSM in Inje area, South Korea. We optimized these models using Bayesian optimization, a method that refines model performance through probabilistic model-based tuning of hyperparameters. The performance of these algorithms was evaluated using accuracy, Kappa score, and F1 score, with accuracy in detecting landslide-prone locations ranging from 0.916 to 0.947. Among them, the tree-based models (RF, LGB, XGB) showed competitive performance and outperformed the other models. Prediction uncertainty was quantified using bootstrapping and Monte Carlo simulation methods, with the latter providing a more consistent estimate across models. Further, the interpretability of ML predictions was analyzed through sensitivity analysis and SHAP values. We also expanded our investigation to include both the inclusion and exclusion of predictors, providing insights into each significant variable through a comprehensive sensitivity analysis. This paper provides insights into the predictive uncertainty and interpretability of ML algorithms for LSM, contributing to future research in South Korea and beyond. | Le, Xuan-Hien; Choi, Chanul; Eu, Song; Yeon, Minho; Lee, Giha | Kyungpook Natl Univ, Dept Adv Sci & Technol Convergence, Sangju, South Korea; Thuyloi Univ, Fac Water Resources Engn, Hanoi, Vietnam; Natl Inst Forest Sci, Dept Forest Environm & Conservat, Seoul, South Korea | Le, Xuan-Hien/AAZ-9166-2021 | 57209735659; 58613779200; 57194056930; 57223436971; 35069799400 | leegiha@knu.ac.kr; | FRONTIERS IN ENVIRONMENTAL SCIENCE | FRONT ENV SCI-SWITZ | 2296-665X | 12 | SCIE | ENVIRONMENTAL SCIENCES | 2024 | 3.7 | 39.4 | 1.03 | 2025-05-07 | 4 | 4 | Bayesian optimization; bootstrapping; landslide susceptibility; Monte Carlo; SHAP; uncertainty analysis | LOGISTIC-REGRESSION; STATISTICAL-METHODS; MODELS; PREDICTION; HAZARD; SOIL | Bayesian optimization; bootstrapping; landslide susceptibility; Monte Carlo; SHAP; uncertainty analysis | English | 2024 | 2024-07-30 | 10.3389/fenvs.2024.1424988 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Triptolide suppresses melanoma cell growth in vitro and in vivo through the Src-ERK signaling pathway | Melanoma is a highly aggressive form of skin cancer with a rapidly increasing incidence. New strategies are urgently needed for treating advanced melanoma which is closely linked to metastasis and often results in death. The Src-ERK signaling axis contributes significantly to both cell growth and metastasis. Triptolide, a Tripterygium wilfordii extract used for treating autoimmune conditions in traditional Chinese medicine, also has anti-inflammatory, neuroprotective, and antitumor activities. However, its ability to treat melanoma, including its target and underlying mechanism, requires clarification. We performed a range of in vivo and in vitro cellular experiments, encompassing assessments of cell proliferation, cell cycle progression, apoptosis, migration, and invasion, alongside nude mouse xenograft tumor studies, to evaluate the therapeutic potential of triptolide in melanoma. Here, it was found that triptolide markedly reduced proliferation, invasion, and migration in SK-MEL-5 and SK-MEL-28 cells. Triptolide was shown to arrest the cell cycle in G0/G1 and induce apoptosis, with further investigation showing that these effects were mediated by the Src-ERK pathway. Thus, the findings indicated that triptolide could inhibit melanoma cell growth and metastasis, suggesting its potential for treating metastatic melanoma. | Zhang, Haibo; Zhang, Zhiqiang; Jiang, Miao; Wang, Shengchao; Wang, Jing; Wang, Hui; Liu, Yanjie; Wang, Youxu; Fu, Junmin; Wang, Penglei; Miao, Mingsan; Kim, Myoung Ok; Fang, Xiaoyan | Henan Univ Chinese Med, Coll Pharm, Zhengzhou 450045, Henan, Peoples R China; Collaborat Innovat Ctr Res Dev Whole Ind Chain Yu, Zhengzhou, Henan, Peoples R China; Henan Univ Chinese Med, Henan Childrens Hosp Integrated Tradit Chinese &, Affiliated Hosp 1, Zhengzhou 450004, Peoples R China; Kyungpook Natl Univ, Dept Anim Sci & Biotechnol, Sangju Si, South Korea | 57221648126; 56593936300; 59394697600; 57211701254; 59394087800; 57214089732; 59394697700; 56011647100; 57201383128; 57208144047; 55428199200; 8934745900; 56562253100 | miaomingsan@163.com;ok4325@knu.ac.kr;fxylele@yeah.net; | JOURNAL OF CANCER | J CANCER | 1837-9664 | 15 | 19 | SCIE | ONCOLOGY | 2024 | 3.2 | 39.4 | 0.47 | 2025-05-07 | 2 | 1 | triptolide; melanoma; Src-ERK pathway; proliferation; metastasis | CANCER STATISTICS; APOPTOSIS | melanoma; metastasis; proliferation; Src-ERK pathway; triptolide | antineoplastic agent; biological marker; mitogen activated protein kinase; protein tyrosine kinase; Tripterygium wilfordii extract; triptolide; adult; aged; anchorage independent growth; animal experiment; animal model; animal tissue; antineoplastic activity; apoptosis; Article; body weight; cancer inhibition; cell cycle progression; cell invasion; cell migration; cell proliferation; cell viability; controlled study; female; G1 phase cell cycle checkpoint; HaCat cell line; human; human cell; immunofluorescence; immunohistochemistry; in vitro study; in vivo study; MAPK signaling; melanoma cell; metastasis inhibition; metastatic melanoma; mouse; nonhuman; SK-MEL-28 cell line; SK-MEL-5 cell line; treatment duration; tumor volume; tumor weight; tumor xenograft; Western blotting | English | 2024 | 2024 | 10.7150/jca.100840 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | A new species of Braunsia (Hymenoptera, Braconidae, Agathidinae), a natural enemy of Cydalima perspectalis (Lepidoptera, Crambidae) from South Korea: species description and notes on its biology | The invasion of Cydalima perspectalis (Walker, 1859) (Lepidoptera, Crambidae) poses a significant threat to European ecosystems and North American ornamentals. In an effort to identify potential biological control agents from the native habitats of C. perspectalis, a field survey was conducted from 2022 to 2024 in South Korea. During the survey, a new braconid agathidine species of Braunsia Kriechbaumer, 1894 was discovered: Braunsia hodorii Kang, sp. nov. The new species is delimited and described based on morphological, molecular, and phylogenetic data. Additionally, information on the behavior of B. hodorii sp. nov. is presented regarding the larval external feeding phase. A key to species of Braunsia in Korea is included accompanied by detailed images. This research contributes to the evaluation of natural enemies as biological control agents against C. perspectalis in its invasive range. | Kim, Soohyun; Choi, Jong Bong; Hwang, Hwal-Su; Kenis, Marc; Seehausen, M. Lukas; Park, Ikju; Choi, Jin-Kyung; Lee, Kyeong-Yeoll; Sharkey, Michael J.; Kang, Ilgoo | Kyungpook Natl Univ, Dept Appl Biol, Daegu, South Korea; Kyungpook Natl Univ, Dept Plant Protect & Quarantine, Daegu, South Korea; Kyungpook Natl Univ, Dept Ecol Sci, Sangju-si, South Korea; CABI, Delemont, Switzerland; Univ Calif Riverside, Dept Entomol, Riverside, CA USA; Daegu Natl Univ Educ, Dept Sci Educ, Daegu, South Korea; Kyungpook Natl Univ, Dept Plant Med, Daegu, South Korea; Hymenoptera Inst, Redlands, CA USA; Kyungpook Natl Univ, Dept Entomol, Sangju Si, South Korea | Seehausen, Martin/C-5782-2016 | 59410068300; 57193335227; 57204055221; 6603975205; 54883929200; 57200320797; 56126660700; 57217153096; 7004167983; 57199506818 | ikang@knu.ac.kr; | JOURNAL OF HYMENOPTERA RESEARCH | J HYMENOPT RES | 1070-9428 | 1314-2607 | 97 | SCIE | ENTOMOLOGY | 2024 | 1.5 | 39.5 | 0 | 2025-05-07 | 0 | 0 | Box tree moth; braconid taxonomy; classical biological control; hymenopteran parasitoid; invasive species | REVISION; SHARKEY; EUROPE; SPREAD; RATES | Box tree moth; braconid taxonomy; classical biological control; hymenopteran parasitoid; invasive species | English | 2024 | 2024-10-24 | 10.3897/jhr.97.135728 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Lactobacillus plantarum isolated from kimchi regulates inflammation by increasing interleukin-10 secretion by antigen-presenting cells, leading to diminishing of STAT5 phosphorylation in Th2 cells | The relationship between allergic inflammation and gut microbiota has been elucidated, and the effect of probiotics on immune disorders has been studied as well. Identifying the role of probiotics in individual diseases and immune responses and selecting and applying specific microorganisms based on these findings can be an effective strategy for using probiotics. Herein, lactobacilli isolated from kimchi were investigated in depth, focusing on their immune regulatory effects and the mechanisms involved. Lactic acid bacteria (LAB) effectively diminished the increased secretion of T helper 2 cytokines, such as IL-4, IL-5, and IL-13, from ovalbumin (OVA)-sensitized mouse splenocytes. The gene expression of GATA3, IL-4, IL-5, IL-9, and IL-13 was confirmed to be regulated by LAB. LAB also suppressed IL-2 production and STAT5 phosphorylation. An IL-10-neutralizing antibody attenuated these effects, indicating that LAB-induced upregulation of IL-10 in antigen-presenting cells was responsible at least partially for the increased IL-2 production and STAT5 phosphorylation in CD4(+ )T cells. In conclusion, the current study identified one immunomodulatory mechanism that allows LAB to regulate allergic immune reactions and the potential of LAB from kimchi to modulate various immune reactions. | Hyung, Kyeong Eun; Yoo, Hyui Kyeong; Ham, Ju Eon; Choi, Jee Yeon; Lee, Sanggyu; Park, So-Young; Hwang, Kwang Woo | Chung Ang Univ, Dept Global Innovat Drugs, 84 Heukseok Ro, Seoul 06974, South Korea; Dankook Univ, Coll Pharm, Cheonan Si, Chungnam, South Korea; Kyungpook Natl Univ, Sch Life Sci, Daegu, South Korea | 47461186200; 59013275900; 58738365200; 58100433600; 7601418915; 57206638690; 7402426778 | Khwang@cau.ac.kr; | JOURNAL OF FOOD SCIENCE | J FOOD SCI | 0022-1147 | 1750-3841 | 89 | 6 | SCIE | FOOD SCIENCE & TECHNOLOGY | 2024 | 3.4 | 39.5 | 0.81 | 2025-05-07 | 2 | 2 | anti-inflammation; immune regulator; microorganism; probiotics; Th2 | ROLES; MODULATION | anti-inflammation; immune regulator; microorganism; probiotics; Th2 | Animals; Antigen-Presenting Cells; Cytokines; Female; Fermented Foods; Inflammation; Interleukin-10; Interleukin-2; Interleukin-4; Interleukin-5; Lactobacillus plantarum; Mice; Mice, Inbred BALB C; Ovalbumin; Phosphorylation; Probiotics; Spleen; STAT5 Transcription Factor; Th2 Cells; cytokine; IL10 protein, mouse; interleukin 10; interleukin 2; interleukin 4; interleukin 5; ovalbumin; probiotic agent; STAT5 protein; animal; antigen presenting cell; Bagg albino mouse; female; fermented product; immunology; inflammation; Lactobacillus plantarum; metabolism; microbiology; mouse; phosphorylation; spleen; Th2 cell | English | 2024 | 2024-06 | 10.1111/1750-3841.17082 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Metabolic differences in Zingiber officinale Roscoe by geographical origin determined via multiplatform metabolomics and method for simultaneous analysis of six phenolic compounds | Ginger, which is the rhizome of Zingiber officinale Roscoe, is widely distributed and consumed. The taste and aroma of ginger differ depending on its geographical origin. To distinguish the origin of ginger, ginger extracts from Korea, Peru, and China were analyzed using ultra-performance liquid chromatography (UPLC) coupled to quadrupole time-of-flight mass spectrometry and nuclear magnetic resonance spectroscopy for metabolomics. Korean ginger contained more 10-gingerol, and Peruvian ginger contained more 6-gingerol and 8-gingerol. Several amino acids negatively correlated with gingerols, suggesting that amino acids are related to the biosynthesis of gingerols. Sugars, which are the main energy source, positively correlated with gingerols. Organic acids and gingerols were also positively correlated, indicating that both organic acids and gingerols are used for adaptation to the environment surrounding the root. We confirmed the features of the primary and secondary metabolites by verifying the correlation between metabolites and differences in metabolites according to ginger origin. We additionally optimized a simultaneous UPLC analytical method of marker compounds for the simple and rapid quality control of ginger. This method exhibits excellent linearity, sensitivity, and reproducibility. Using metabolomics, differences in origin were observed, and a low-end equipment analysis method for quality control can be used in the ginger industry. | Yoon, Dahye; Choi, Bo-Ram; Kim, Hyoung-Geun; Lee, Dae Young | Natl Inst Hort & Herbal Sci, Dept Herbal Crop Res, RDA, Eumseong, South Korea; Nat Prod Res Ctr & Nat Prod Cent Bank, KRIBB, Ochang, South Korea; Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat BioRes Grp, Daegu 41566, South Korea | 55855383700; 57194340567; 57192300072; 57750904900 | dylee80@knu.ac.kr; | JOURNAL OF FOOD SCIENCE | J FOOD SCI | 0022-1147 | 1750-3841 | 89 | 11 | SCIE | FOOD SCIENCE & TECHNOLOGY | 2024 | 3.4 | 39.5 | 0 | 2025-05-07 | 0 | 0 | geographical origin; ginger; gingerols; multiplatform metabolomics | GINGER; 6-SHOGAOL; 6-GINGEROL | geographical origin; ginger; gingerols; multiplatform metabolomics | Catechols; China; Chromatography, High Pressure Liquid; Fatty Alcohols; Magnetic Resonance Spectroscopy; Mass Spectrometry; Metabolomics; Peru; Phenols; Plant Extracts; Reproducibility of Results; Republic of Korea; Rhizome; Zingiber officinale; 8-gingerol; catechol derivative; fatty alcohol; gingerol; phenol derivative; plant extract; chemistry; China; ginger; high performance liquid chromatography; mass spectrometry; metabolism; metabolomics; nuclear magnetic resonance spectroscopy; Peru; procedures; reproducibility; rhizome; South Korea | English | 2024 | 2024-11 | 10.1111/1750-3841.17456 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Modeling Pollutant Diffusion in the Ground Using Conformable Fractional Derivative in Spherical Coordinates with Complete Symmetry | The conformal fractional derivative (CFD) has become a hot research topic since it has a physical interpretation and is easier to grasp and apply to problems compared with other fractional derivatives. Its application to heat transfer, diffusion, diffusion-advection, and wave propagation problems can be found in the literature. Fractional diffusion equations have received great attention recently due to their applicability in physical, chemical, and biological processes and engineering. The diffusion of the pollutants within the ground, which is an important environmental problem, can be modeled with a diffusion equation. Diffusion in some porous materials or soil can be modeled more accurately with fractional derivatives or the conformal fractional derivative. In this study, the diffusion problem of a spilled pollutant leaking into the ground modeled with the conformal fractional time derivative in spherical coordinates has been solved analytically using the Fourier series for a constant mass flow rate and complete symmetry under the assumptions of homogeneous and isotropic soil, constant soil temperature, and constant permeability. The solutions have been simulated spatially and in time. A parametric analysis of the problem has been performed for several values of the CFD order. The simulation results are interpreted. It has also been suggested how to find the parameters of the soil to see whether the CFD can be used to model the soil or not. The approach described here can also be used for modeling pollution problems involving different boundary conditions. | Kim, Mintae; Mert Coskun, Oya; Ordu, Seyma; Mutlu, Resat | Kyungpook Natl Univ, Sch Architecture Civil Environm & Energy Engn, Daegu 41566, South Korea; Tekirdag Namik Kemal Univ, Dept Math, TR-59030 Tekirdag, Turkiye; Tekirdag Namik Kemal Univ, Dept Environm Engn, TR-59030 Tekirdag, Turkiye; Tekirdag Namik Kemal Univ, Dept Elect & Elect Engn, TR-59030 Tekirdag, Turkiye | ; Kim, Mintae/KIA-5487-2024; Mutlu, Resat/ABA-5309-2020 | 56754342900; 57198448832; 26325060700; 36515307500 | mtkim@knu.ac.kr;oyamert@nku.edu.tr;sordu@nku.edu.tr;rmutlu@nku.edu.tr; | SYMMETRY-BASEL | SYMMETRY-BASEL | 2073-8994 | 16 | 10 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 2.2 | 39.6 | 0 | 2025-05-07 | 0 | 0 | fractional-order derivative; conformal fractional derivative; diffusion equation; pollutant transfer | FINITE-DIFFERENCE APPROXIMATION; EQUATION | conformal fractional derivative; diffusion equation; fractional-order derivative; pollutant transfer | English | 2024 | 2024-10 | 10.3390/sym16101358 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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