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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | Article | Stenotrophomonas maltophilia outer membrane vesicles elicit a potent inflammatory response in vitro and in vivo | Stenotrophomonas maltophilia has become one of the most prevalent opportunistic pathogens in hospitalized patients. This microorganism secretes outer membrane vesicles (OMVs), but the pathogenesis of S. maltophilia as it relates to OMVs has not been characterized. This study investigated the cytotoxic activity of S. maltophilia OMVs and their ability to induce inflammatory responses both in vitro and in vivo. Stenotrophomonas maltophilia ATCC 13637 and two clinical isolates were found to secrete spherical OMVs during in vitro culture. OMVs from S. maltophilia ATCC 13637 were cytotoxic to human lung epithelial A549 cells. Stenotrophomonas maltophilia OMVs stimulated the expression of proinflammatory cytokine and chemokine genes, including interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor-α and monocyte chemoattractant protein-1, in A549 cells. Early inflammatory responses such as congestion and neutrophilic infiltrations and profound expression of proinflammatory cytokine and chemokine genes were observed in the lungs of mice injected with S. maltophilia OMVs, and were similar to responses elicited by the bacteria. Our data demonstrate that S. maltophilia OMVs are important secretory nanocomplexes that elicit a potent inflammatory response that might contribute to S. maltophilia pathogenesis during infection. © FEMS 2016. All rights reserved. | Kim, Yoo Jeong; Jeon, Hyejin; Na, Seok Hyeon; Kwon, Hyo Il; Selasi, Gati Noble; Nicholas, Asiimwe; Park, Tae In; Lee, Sang Hwa; Lee, Je Chul | Department of Microbiology, Kyungpook National University School of Medicine, Daegu, 41944, South Korea; Department of Microbiology, Kyungpook National University School of Medicine, Daegu, 41944, South Korea; Department of Microbiology, Kyungpook National University School of Medicine, Daegu, 41944, South Korea; Department of Microbiology, Kyungpook National University School of Medicine, Daegu, 41944, South Korea; Department of Microbiology, Kyungpook National University School of Medicine, Daegu, 41944, South Korea; Department of Microbiology, Kyungpook National University School of Medicine, Daegu, 41944, South Korea; Department of Pathology, Kyungpook National University School of Medicine, Daegu, 41944, South Korea; Department of Microbiology, Dong-A University, College of Medicine, Busan, 49201, South Korea; Department of Microbiology, Kyungpook National University School of Medicine, Daegu, 41944, South Korea | 57145413200; 56822943800; 57146591600; 57145923200; 56823535700; 56823170600; 7401801814; 57038130500; 25930392000 | leejc@knu.ac.kr; | Pathogens and Disease | PATHOG DIS | 2049-632X | 2049-632X | 74 | 8 | SCIE | IMMUNOLOGY;INFECTIOUS DISEASES;MICROBIOLOGY | 2021 | 3.951 | 51.5 | 2.07 | 2025-07-30 | 28 | Cytokine; Cytotoxicity; Inflammation; Outer membrane vesicle; Stenotrophomonas maltophilia | Animals; Cell Line; Cell Membrane; Cytokines; Disease Models, Animal; Epithelial Cells; Female; Gene Expression; Gram-Negative Bacterial Infections; Humans; Inflammation; Inflammation Mediators; Mice; Secretory Vesicles; Stenotrophomonas maltophilia; Transport Vesicles; complementary DNA; glyceraldehyde 3 phosphate dehydrogenase; interleukin 1beta; interleukin 6; interleukin 8; monocyte chemotactic protein; monocyte chemotactic protein 1; RNA directed DNA polymerase; tumor necrosis factor; autacoid; cytokine; A-549 cell line; animal experiment; animal model; animal tissue; Article; cell culture; cell infiltration; controlled study; cytotoxicity; female; human; human cell; in vitro study; in vivo study; innate immunity; lung parenchyma; mouse; neutrophil; nonhuman; outer membrane; outer membrane vesicle; pneumonia; priority journal; protein expression; real time reverse transcription polymerase chain reaction; RNA isolation; software; Stenotrophomonas maltophilia; transmission electron microscopy; animal; cell line; cell membrane; disease model; epithelium cell; gene expression; genetics; Gram negative infection; inflammation; metabolism; microbiology; pathogenicity; physiology; secretory vesicle; Stenotrophomonas maltophilia; transport vesicle | English | Final | 2021 | 10.1093/femspd/ftw104 | 바로가기 | 바로가기 | 바로가기 | |||||||
| ○ | ○ | Article | Engineered extracellular vesicle mimetics from macrophage promotes hair growth in mice and promotes human hair follicle growth | Recent studies clearly show that cell-derived extracellular vesicles (EVs, including exosomes) can promote hair growth. However, large-scale production of EVs remains a big hurdle. Recently, extracellular vesicle mimetics (EMs) engineered by extrusion through various membranes are emerging as a complementary approach for largescale production. In this study, to investigate their ability to induce hair growth, we generated macrophage-engineered EMs (MAC-EMs) that activated the human dermal papilla (DP) cells in vitro. MAC-EMs intradermally injected into the skin of C57BL/6 mice were retained for up to 72 h. Microscopy imaging revealed that MAC-EMs were predominately internalized into hair follicles. The MAC-EMs treatment induced hair regrowth in mice and hair shaft elongation in a human hair follicle, suggesting the potential of MAC-EMs as an alternative to EVs to overcome clinical limitation. | Rajendran, Ramya Lakshmi; Gangadaran, Prakash; Kwack, Mi Hee; Oh, Ji Min; Hong, Chae Moon; Gopal, Arunnehru; Sung, Young Kwan; Lee, Jaetae; Ahn, Byeong-Cheol | Kyungpook Natl Univ, Sch Med, Dept Nucl Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, BK21 FOUR KNU Convergence Educ Program Biomed Sci, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Immunol, Daegu, South Korea; Kyungpook Natl Univ Hosp, Dept Nucl Med, Daegu, South Korea | Gangadaran, Prakash/AAV-3102-2021; Rajendran, Ramya/AAV-6338-2021 | 57195318729; 54393130400; 6507685557; 57190370462; 37050876700; 57203278478; 55663365300; 7601451907; 7202791511 | abc2000@knu.ac.kr; | EXPERIMENTAL CELL RESEARCH | EXP CELL RES | 0014-4827 | 1090-2422 | 409 | 1 | SCIE | CELL BIOLOGY;ONCOLOGY | 2021 | 4.145 | 51.6 | 0.59 | 2025-07-30 | 8 | 9 | Extracellular vesicle mimetics; Macrophage; Hair growth; Mice and human hair follicle | Extracellular vesicle mimetics; Hair growth; Macrophage; Mice and human hair follicle | Animals; Cell Proliferation; Cells, Cultured; Dermis; Exosomes; Extracellular Vesicles; Hair; Hair Follicle; Humans; Macrophages; Male; Mice; Mice, Inbred C57BL; RAW 264.7 Cells; Skin; Wnt Signaling Pathway; animal cell; animal experiment; article; C57BL 6 mouse; exosome; hair follicle; hair growth; human; in vitro study; macrophage; male; microscopy; mouse; nonhuman; skin; animal; C57BL mouse; cell culture; cell proliferation; dermis; exosome; growth, development and aging; hair; hair follicle; macrophage; metabolism; physiology; RAW 264.7 cell line; Wnt signaling | English | 2021 | 2021-12-01 | 10.1016/j.yexcr.2021.112887 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | A prognostic immune predictor, HLA-DRA, plays diverse roles in nonmuscle invasive and muscle invasive bladder cancer | Background: There is an increasing demand for prognostic immune biomarkers of cancer. The prognostic significance of immune markers has been shown for various cancers, but biomarkers of bladder cancer (BCa) have not been fully evaluated. To clarify the role of human leukocyte antigen DR alpha chain (HLA-DRA) in BCa development, we examined expression of HLA-DRA mRNA in tissue samples of non-muscle invasive bladder cancer (NMIBC) and muscle invasive bladder cancer (MIBC). Materials and Methods: Tissues of 96 NMIBC, 43 MIBC and 59 controls comprising noncancerous BCa surrounding tissues were used to examine the expression of HLA-DRA gene by real-time polymerase chain reaction. The expression of up-stream genes regulating HLADRA were also measured to explain the role of HLA-DRA in BCa. Results: Patients with high grade NMIBC showed higher expression of HLA-DRA than those with low grade NMIBC (P < 0.05). In addition, NMIBC patients who progressed to MIBC showed high expression of HLA-DRA mRNA. Kaplan-Meier analysis showed that NMIBC patients with low expression of HLA-DRA had better progression-free survival than those with high expression (P = 0.004). Moreover, the expression of genes regulating HLA-DRA varied in NMIBC and MIBC, indicating a different immunoregulation effect of HLA-DRA in both cancers. Conclusions: High expression of HLA-DRA in NMIBC patients has implications for patient stratification strategies, as well as for BCa tumor immunology. (C) 2020 Elsevier Inc. All rights reserved. | Piao, Xuan-Mei; Kang, Ho Won; Jeong, Pildu; Byun, Young Joon; Lee, Hee Youn; Kim, Kyeong; Seo, Sung Phil; Kim, Won Tae; Lee, Jong-Young; Ha, Yun-Sok; Choi, Yung Hyun; Moon, Sung-Kwon; Yun, Seok Joong; Kim, Wun-Jae | Chungbuk Natl Univ, Coll Med, Dept Urol, Cheongju, South Korea; Chungbuk Natl Univ Hosp, Dept Urol, Cheongju, South Korea; One Inst, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Urol, Daegu, South Korea; Kyungpook Natl Univ Hosp, Dept Urol, Daegu, South Korea; Dong Eui Univ, Dept Biochem, Coll Oriental Med, Busan, South Korea; Chung Ang Univ, Dept Food Sci & Technol, Ansung, South Korea; Inst Urotech, Cheongju, South Korea | Piao, Xuan-Mei/ABI-6955-2020; Kim, Jin Man/HJO-8987-2023; Kim, Yoosuk/JDD-2639-2023; Kim, Kyu/E-7814-2012; Lee, Jong-Young/M-6319-2013 | 57188653344; 35757703900; 8890123500; 57188656800; 57217589965; 57220864860; 56115644100; 57203514393; 57820672500; 35487226400; 57211727369; 7401616572; 16302421300; 8081691400 | sjyun@chungbuk.ac.kr;wjkim@chungbuk.ac.kr; | UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS | UROL ONCOL-SEMIN ORI | 1078-1439 | 1873-2496 | 39 | 4 | SCIE | ONCOLOGY;UROLOGY & NEPHROLOGY | 2021 | 2.954 | 51.7 | 1.52 | 2025-07-30 | 21 | 19 | Immune biomarker; HLA-DRA; Prognosis; Nonmuscle invasive bladder cancer; Muscle invasive bladder cancer | HLA-DRA; Immune biomarker; Muscle invasive bladder cancer; Nonmuscle invasive bladder cancer; Prognosis | Aged; Biomarkers, Tumor; Female; Gene Expression Regulation, Neoplastic; HLA-DR alpha-Chains; Humans; Male; Middle Aged; Neoplasm Invasiveness; Prognosis; Urinary Bladder Neoplasms; antineoplastic agent; gamma interferon; HLA DR antigen; interleukin 10; messenger RNA; HLA DR antigen; tumor marker; adult; aged; Article; cancer prognosis; cancer specific survival; controlled study; cystectomy; data analysis software; female; gene expression; human; human tissue; immunoregulation; major clinical study; male; middle aged; muscle invasive bladder cancer; non muscle invasive bladder cancer; priority journal; progression free survival; real time polymerase chain reaction; tissue microarray; tumor immunity; urine cytology; bladder tumor; gene expression regulation; genetics; immunology; pathology; prognosis; tumor invasion | English | 2021 | 2021-04 | 10.1016/j.urolonc.2020.11.017 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Anti-Inflammatory and Anti-Vascular Leakage Effects by Combination of Centella asiatica and Vitis vinifera L. Leaf Extracts | Venous insufficiency results from several factors responsible for the progression of inflammation and oxidative damage of veins. Recently, natural extracts have been proposed for the treatment of venous insufficiency, but their efficacies have not been fully elucidated. In the present study, we evaluate the combinatorial effects on anti-inflammatory and anti-vascular leakage potential of mixed compositions containing different proportions of Centella asiatica extract (CE) and Vitis vinifera L. leaf extract (VVE) using an inflammation model of lipopolysaccharide- (LPS-) stimulated RAW264.7 cells and various vascular permeability models in mice (acetic-acid-induced peritoneal vascular model, mustard-oil-stimulated ear vascular model, and carrageenan-induced paw edema model). Pretreatment of CE and VVE in a 1 : 3 combination dose dependently inhibited the production of nitric oxide (NO) and prostaglandin E-2 (PGE(2)) and mRNA expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) through downregulation of the nuclear factor-kappa B (NF-kappa B) pathway in LPS-stimulated RAW264.7 macrophages. In vascular permeability-related mouse models, pretreatment with the CE-VVE 1 : 3 combination significantly reduced the permeability of peritoneal or ear veins caused by acetic acid and mustard oil, respectively. Furthermore, pretreatment of the CE-VVE 1 : 3 combination ameliorated inflammation and edema of the hind paw caused by carrageenan injection. Thus, the combination of CE and VVE showed significant anti-inflammatory qualities and anti-vascular leakage effects. These findings indicate that an optimal combination of CE and VVE may have a more synergistic effect than that of CE or VVE alone as a putative agent against vascular incompetence. | Seo, Myung-Gi; Jo, Min-Jeong; Hong, Nam In; Kim, Min Jung; Shim, Kyu Suk; Shin, Eunju; Lee, Jeong Jun; Park, Sang-Joon | Kyungpook Natl Univ, Coll Vet Med, Dept Histol, Daegu 41566, South Korea; Univ Co Ltd, Econet Ctr, 78,Achasan Ro, Seoul 04789, South Korea; Naturetech Co, 450-86,Maebong Ro, Cheonan Si 330863, Chungnam, South Korea | KIM, MINJUNG/JPK-2924-2023; Lee, Jongyeol/F-8932-2015 | 57200912013; 57223119334; 57223122325; 59807541600; 7102387746; 20735508300; 57214357024; 7501825941 | newmoon93@knu.ac.kr;cmjdgt@naver.com;lunawind0317@naver.com;mjkim@univera.com;kssim93@univera.com;ejayshin@univera.com;jjlee@naturetech.co.kr;psj26@knu.ac.kr; | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | EVID-BASED COMPL ALT | 1741-427X | 1741-4288 | 2021 | SCIE | INTEGRATIVE & COMPLEMENTARY MEDICINE | 2021 | 2.65 | 51.7 | 1.68 | 2025-07-30 | 7 | 11 | TOTAL TRITERPENIC FRACTION; EDEMA; MICROANGIOPATHY; INHIBITION; LEAVES; MICE | acetic acid; allyl isothiocyanate; carrageenan; Centella asiatica extract; cyclooxygenase 2; dexamethasone; immunoglobulin enhancer binding protein; inducible nitric oxide synthase; lipopolysaccharide; messenger RNA; nitric oxide; prostaglandin E2; vascular targeting agent; Vitis vinifera extract; animal cell; animal experiment; animal model; antiinflammatory activity; Article; blood vessel permeability; carrageenan-induced paw edema; Centella asiatica; controlled study; down regulation; drug isolation; drug potentiation; grape; male; mouse; nonhuman; protein expression; RAW 264.7 cell line; synergistic effect | English | 2021 | 2021-04-14 | 10.1155/2021/7381620 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Antihyperuricemic Effect of Dendropanax morbifera Leaf Extract in Rodent Models | Dendropanax morbifera is a well-known traditional medicine used in China and Korea to treat intestinal disorders, urosis, diuresis, and chronic glomerulonephritis. Hyperuricemia is a metabolic disorder characterized by a high uric acid level in serum due to an imbalance between uric acid production and excretion and causes gout. Recently, the prevalence of hyperuricemia worldwide has been continuously increasing. Xanthine oxidase (XOD) inhibitors (allopurinol (ALP) and febuxostat) and uricosuric agents (benzbromarone and probenecid) are used to treat hyperuricemia clinically. However, because these drugs are poorly tolerated and cause side effects, such as kidney diseases, hepatotoxicity, gastrointestinal symptoms, and hypersensitivity syndrome, only a limited number of drugs are available. We investigated the antihyperuricemic effects of Dendropanax morbifera leaf ethanol extract (DMLE) and its underlying mechanisms of action through in vitro and in vivo studies. We evaluated uric acid levels in serum and urine, and xanthine oxidase (XOD) inhibition activity in the serum and liver tissue of a hyperuricemic rat model of potassium oxonate (PO)-induced hyperuricemic rats. In vitro study, XOD-inhibitory activity was the lowest among the test substances at the IC50 of ALP. However, the IC50 of DMLE-70 was significantly low compared with that of other DMLEs (p<0.05). In PO-induced hyperuricemic rats, uric acid (UA) levels in serum and urine were significantly reduced in all DMLE-70 and allopurinol-treated (ALT) groups than in the PC group (p<0.05). UA levels in urine were lower than those in serum in all DME groups. In PO-induced hyperuricemic rats, DMEE-200 reduced UA concentration in serum and increased UA excretion in the urine. These findings suggest that DMLE exerts antihyperuricemic and uricosuric effects on promoting UA excretion by enhanced secretion and inhibition of UA reabsorption in the kidneys. Thus, DMLE may be a potential treatment for hyperuricemia and gout. | Lee, Dongho; Kim, Jin-Kyoung; Han, Yongjae; Park, Kwang Il | Inje Univ, Coll Med, Dept Anesthesiol & Pain Med, Gimhae 47392, South Korea; Kyungpook Natl Univ, Dept Prevent Dent, Sch Dent, Daegu 41940, South Korea; Daegu Hlth Coll, Dept Dent Hyg, Daegu 41453, South Korea; Gyeongsang Natl Univ, Inst Anim Med, Jinju 52728, South Korea; Gyeongsang Natl Univ, Coll Vet Med, Jinju 52728, South Korea | 57226773513; 57226774190; 58499476200; 55722171100 | kipark@gnu.ac.kr; | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | EVID-BASED COMPL ALT | 1741-427X | 1741-4288 | 2021 | SCIE | INTEGRATIVE & COMPLEMENTARY MEDICINE | 2021 | 2.65 | 51.7 | 0.76 | 2025-07-30 | 5 | 5 | URIC-ACID; RENAL DYSFUNCTION; HYPERURICEMIA; ANTIOXIDANT; RUTIN | allopurinol; chlorogenic acid; Dendropanax morbifera extract; oteracil potassium; plant extract; reactive oxygen metabolite; rutoside; unclassified drug; uric acid; xanthine oxidase; animal experiment; animal model; antioxidant activity; Araliaceae; Article; controlled study; cytotoxicity; Dendropanax morbifera; gout; human; human cell; hyperuricemia; IC50; in vitro study; in vivo study; liver tissue; male; nonhuman; plant leaf; rat; uric acid blood level; uric acid urine level | English | 2021 | 2021-07-23 | 10.1155/2021/3732317 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Antiplatelet and Antithrombotic Effects of Epimedium koreanum Nakai | Background and Objective. Epimedium koreanum Nakai is a medicinal plant known for its health beneficial effects on impotence, arrhythmia, oxidation, aging, osteoporosis, and cardiovascular diseases. However, there is no report available that shows its effects on platelet functions. Here, we elucidated antiplatelet and antithrombotic effects of ethyl acetate fraction of E. koreanum. Methodology. We analyzed the antiplatelet properties using standard in vitro and in vivo techniques, such as light transmission aggregometry, scanning electron microscopy, intracellular calcium mobilization measurement, dense granule secretion, and flow cytometry to assess integrin alpha (IIb)beta (3) activation, clot retraction, and Western blot, on washed platelets. The antithrombotic effects of E. koreanum were assessed by arteriovenous- (AV-) shunt model in rats, and its effects on hemostasis were analyzed by tail bleeding assay in mice. Key Results. E. koreanum inhibited platelet aggregation in agonist-stimulated human and rat washed platelets, and it also reduced calcium mobilization, ATP secretion, and TXB2 formation. Fibrinogen binding, fibronectin adhesion, and clot retraction by attenuated integrin alpha (IIb)beta (3)-mediated inside-out and outside-in signaling were also decreased. Reduced phosphorylation of extracellular signal-regulated kinases (ERK), Akt, PLC gamma 2, and Src was observed. Moreover, the fraction inhibited thrombosis. HPLC results revealed that the fraction predominantly contained icariin. Conclusion and Implications. E. koreanum inhibited platelet aggregation and thrombus formation by attenuating calcium mobilization, ATP secretion, TXB2 formation, and integrin alpha (IIb)beta (3) activation. Therefore, it may be considered as a potential candidate to treat and prevent platelet-related cardiovascular disorders. | Irfan, Muhammad; Kwon, Tae-Hyung; Lee, Dong-Ha; Hong, Seung-Bok; Oh, Jae-Wook; Kim, Sung-Dae; Rhee, Man Hee | Kyungpook Natl Univ, Coll Vet Med, Dept Vet Med, Daegu 41566, South Korea; Univ Illinois, Coll Dent, Dept Oral Biol, Chicago, IL 60607 USA; Chuncheon Bio Ind Fdn, Chunchon 24232, South Korea; Chungbuk Hlth & Sci Univ, Dept Clin Lab Sci, Chungbuk 28150, South Korea; Namseoul Univ, Dept Biomed Lab Sci, Cheonan 31020, South Korea; Namseoul Univ, Mol Diagnost Res Inst, Cheonan 31020, South Korea; Konkuk Univ, Dept Stem Cell & Regenerat Biotechnol, KIT, Seoul 05029, South Korea; Dongnam Inst Radiol & Med Sci, Res Ctr, Busan 46033, South Korea | ; Oh, Jae-Wook/D-3597-2011; Rhee, Man/O-5705-2016; Irfan, Muhammad/AAY-1961-2021 | 35069404400; 55419730800; 57208891222; 9237099500; 34875481900; 55156746000; 57211035357 | rheemh@knu.ac.kr; | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | EVID-BASED COMPL ALT | 1741-427X | 1741-4288 | 2021 | SCIE | INTEGRATIVE & COMPLEMENTARY MEDICINE | 2021 | 2.65 | 51.7 | 1.83 | 2025-07-30 | 14 | 14 | CARDIOVASCULAR-DISEASE; KINASES; GINSENOSIDES; ACTIVATION; THROMBUS; GINSENG | acetic acid ethyl ester; acetylsalicylic acid; antithrombocytic agent; caffeic acid; chlorogenic acid; ellagic acid; Epimedium extract; Epimedium koreanum extract; fibrinogen; fibronectin; gallic acid; icariin; kaempferol; mitogen activated protein kinase; myricetin; protein kinase B; quercetin; thromboxane B2; unclassified drug; animal cell; animal experiment; animal model; antiplatelet activity; antithrombotic activity; arteriovenous shunt; Article; blood clot retraction; calcium cell level; calcium mobilization; controlled study; Epimedium koreanum; flow cytometry; high performance liquid chromatography; human; human experiment; in vitro study; in vivo study; male; mouse; nonhuman; normal human; platelet-rich plasma cell; protein phosphorylation; rat; scanning electron microscopy; thrombocyte activation; thrombocyte aggregation; thrombocyte function; thrombocyte rich plasma; ultrastructure | English | 2021 | 2021-04-17 | 10.1155/2021/7071987 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Derrone Inhibits Platelet Aggregation, Granule Secretion, Thromboxane A2 Generation, and Clot Retraction: An In Vitro Study | Cudrania tricuspidata (C. tricuspidata) is widespread throughout East Asia and in China and Korea, and it is widely used as a traditional remedy against eczema, mumps, and tuberculosis. With regard to the aforementioned medical efficacy, various studies are continuously being conducted, and it has been reported that C. tricuspidata extract has various actions against inflammation, diabetes, obesity, and tumors. Therefore, we evaluated antiplatelet effects using derrone in C. tricuspidata. We examined the effect of derrone on the phosphorylation of vasodilator-stimulated phosphoprotein (VASP) and inositol 1, 4, 5-triphosphate receptor I (IP3RI), and on the dephosphorylation of cytosolic phospholipase A(2) (cPLA(2)), mitogen-activated protein kinases p38 (p38(MAPK)), and Akt, which affects platelet function and thrombus formation. Various agonists-induced human platelets were inhibited by derrone without cytotoxicity, and it also decreased the intracellular calcium level through the signaling molecule phosphorylations. In addition, derrone inhibited glycoprotein IIb/IIIa (alpha IIb/beta 3) affinity. Thus, in the present study, derrone suppressed human platelet aggregation and thrombin-induced clot formation. | Shin, Jung-Hae; Irfan, Muhammad; Rhee, Man Hee; Kwon, Hyuk-Woo | Catholic Kwandong Univ, Dept Biomed Lab Sci, Kangnung 25601, South Korea; Kyungpook Natl Univ, Coll Vet Med, Lab Physiol & Cell Signaling, Daegu 41566, South Korea; Univ Illinois, Dept Oral Biol, Chicago, IL 60607 USA; Far East Univ, Dept Biomed Lab Sci, Eumseong 27601, South Korea | Rhee, Man/O-5705-2016; Irfan, Muhammad/AAY-1961-2021 | 56244056800; 35069404400; 57211035357; 55200547400 | kwonhw@kdu.ac.kr; | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | EVID-BASED COMPL ALT | 1741-427X | 1741-4288 | 2021 | SCIE | INTEGRATIVE & COMPLEMENTARY MEDICINE | 2021 | 2.65 | 51.7 | 0.46 | 2025-07-30 | 5 | 4 | CUDRANIA-TRICUSPIDATA; ANTIPLATELET; RECEPTOR; PHOSPHORYLATION | 15 hydroxy 11alpha,9alpha epoxymethanoprosta 5,13 dienoic acid; antithrombocytic agent; collagen; derrone; fibrinogen receptor; inositol 1,4,5 triphosphate receptor i; inositol 1,4,5 trisphosphate receptor; mitogen activated protein kinase p38; phospholipase A2; protein kinase B; thrombin; thromboxane A2; unclassified drug; vasodilator stimulated phosphoprotein; antiplatelet activity; Article; blood clot retraction; calcium cell level; Cudrania tricuspidata; cytotoxicity; drug efficacy; human; human cell; in vitro study; protein dephosphorylation; protein phosphorylation; thrombocyte aggregation; thrombocyte release reaction; traditional medicine | English | 2021 | 2021-03-11 | 10.1155/2021/8855980 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Duchesnea indica Extract Attenuates Coal Fly Ash-Induced Inflammation in Murine Alveolar Macrophages through the NF-Kappa B Pathway | Duchesnea indica is known as false strawberry, is found in East Asia, and has numerous biological properties. The aim of this study was to investigate the anti-inflammatory effect of Duchesnea indica extract (DIE) on coal fly ash- (CFA-) induced inflammation in murine alveolar macrophages (MH-S). Following the induction of inflammation in MH-S cells by CFA, nitric oxide (NO) was measured to evaluate the anti-inflammatory property of DIE. Cell viability and inflammatory gene expression were analyzed using polymerase chain reaction (PCR). The inflammatory pathway in MH-S cells was determined via western blotting and immunofluorescence (IF) analysis. Finally, the major components of the DIE were identified and separated through ultra-performance liquid chromatography (UPLC) and gas chromatography-mass spectrometry (GC-MS) analysis. Our results showed that the DIE dose-dependently inhibited the CFA-induced NO production in MH-S cells. Moreover, the DIE could suppress the CFA-induced proinflammatory mediators, such as cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). In addition, the inhibitory effect of the DIE on proinflammatory cytokines, including interleukin-6 (IL-6), IL-1 beta, and tumor necrosis factor-alpha (TNF-alpha), was detected with PCR. Moreover, the effect of the DIE on the nuclear factor-kappa B (NF-kappa B) pathway in CFA-activated MH-S cells was measured via western blotting. Furthermore, the inhibition of the phosphorylated NF-kappa B (p-NF-kappa B) translocation was analyzed using IF assay. The findings of this study indicated that the DIE potentially inhibited the CFA-induced inflammation by blocking the NF-kappa B inflammatory signaling pathway in MH-S cells and that the DIE might contain favorable anti-inflammatory compounds which may be effective in attenuating lung inflammation. | Ullah, H. M. Arif; Lee, Yuan Yee; Kim, Sung Dae; Rhee, Man Hee | Kyungpook Natl Univ, Coll Vet Med, Dept Vet Med, Daegu 41566, South Korea | ; Rhee, Man/O-5705-2016; Ullah, H/AAE-5513-2021; Yuan Yee, Lee/ABH-8956-2022 | 57198885380; 57203798815; 55156746000; 57211035357 | arif55dml@knu.ac.kr;yuanyeelee@knu.ac.kr;kim79sd@knu.ac.kr;rheemh@knu.ac.kr; | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | EVID-BASED COMPL ALT | 1741-427X | 1741-4288 | 2021 | SCIE | INTEGRATIVE & COMPLEMENTARY MEDICINE | 2021 | 2.65 | 51.7 | 1.38 | 2025-07-30 | 10 | 10 | ELLAGIC ACID; IN-VITRO; SUPPRESSION; MECHANISMS; CYTOKINES | 2,3 dihydro 3,5 dihydroxy 6 methyl (4h) pyran 4 one; alcohol; antiinflammatory agent; cyclooxygenase 2; Duchesnea indica extract; gamma sitosterol; I kappa B; immunoglobulin enhancer binding protein; inducible nitric oxide synthase; interleukin 1beta; interleukin 6; linoelaidic acid; linolenic acid; nitric oxide; palmitic acid; phytochemical; plant extract; stearic acid; tumor necrosis factor; unclassified drug; animal cell; antiinflammatory activity; Article; cell viability; controlled study; cytokine production; drug cytotoxicity; drug effect; drug mechanism; Duchesnea indica; experimental inflammation; fly ash; gene expression; immunofluorescence microscopy; lung alveolus macrophage; macrophage activation; mass fragmentography; mediator release; MH-S cell line; NF kB signaling; nonhuman; real time polymerase chain reaction; reverse transcription polymerase chain reaction; Rosaceae; solvent extraction; ultra performance liquid chromatography; Western blotting | English | 2021 | 2021-06-07 | 10.1155/2021/5546052 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Inhibitory Effect of Phellinus baumii Extract on CFA-Induced Inflammation in MH-S Cells through Nuclear Factor-κB and Mitogen-Activated Protein Kinase Signaling Pathways | Phellinus baumii is a mushroom utilized as a traditional medicine for a wide range of human ailments, including diabetes, hypertension, hypercholesterolemia, and cancer, in Asia.The purpose of this study was to find out whether Phellinus baumii extract (PBE) could reduce inflammation caused by coal fly ash (CFA) in alveolar macrophages (MH-S).The anti-inflammatory effect of PBE was evaluated by measuring the nitric oxide (NO) concentration after the onset of CFA-stimulated inflammation in MH-S cells. Polymerase chain reaction (PCR) was used to examine inflammatory gene expression. Western blotting and immunofluorescence (IF) studies were used to investigate the inflammatory mechanism in MH-S cells. According to our results, the PBE suppressed CFA-induced NO generation in the MH-S cells dose-dependently. Furthermore, PBE inhibited the proinflammatory mediators and cytokines generated by exposure to CFA, including cyclooxygenase 2 (COX-2) and inducible NO synthase (iNOS), interleukin (IL)-1 beta, IL-6, and tumor necrosis factor-alpha (TNF-alpha). Real-time PCR was also used to determine the inhibiting effect of the PBE on proinflammatory factors such as COX-2, iNOS, IL-1 beta, IL-6, and TNF-alpha. Moreover, Western blot was used to assess the effects of the PBE on the nuclear factor-kappa B (NF-kappa B) and mitogen-activated protein kinase (MAPK) pathways in the CFA-stimulated MH-S cells.The suppressive effect of the PBE on phosphorylated (p)-NF-kappa B translocation was also investigated using IF analysis.This study showed that the PBE suppressed the CFA-induced inflammation in the MH-S cells by suppressing the NF-kappa B and MAPK signaling pathways, which suggests its potential usefulness in reducing lung inflammation. | Ullah, H. M. Arif; Lee, Yuan Yee; Yun, Bong-Sik; Kim, Sung Dae; Rhee, Man Hee | Kyungpook Natl Univ, Cardiovasc Res Inst, Dept Vet Med, Daegu 41566, South Korea; Kyungpook Natl Univ, Coll Vet Med, Daegu 41566, South Korea; Univ Utah, Dept Neurobiol, Salt Lake City, UT USA; Jeonbuk Natl Univ, Coll Environm & Bioresource Sci, Div Biotechnol, Gobong Ro 79, Iksan 54596, South Korea; Jeonbuk Natl Univ, Coll Environm & Bioresource Sci, Adv Inst Environm & Biosci, Gobong Ro 79, Iksan 54596, South Korea | Ullah, H/AAE-5513-2021; Rhee, Man/O-5705-2016; Yuan Yee, Lee/ABH-8956-2022 | 57198885380; 57203798815; 7201805685; 55156746000; 57211035357 | rheemh@knu.ac.kr; | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | EVID-BASED COMPL ALT | 1741-427X | 1741-4288 | 2021 | SCIE | INTEGRATIVE & COMPLEMENTARY MEDICINE | 2021 | 2.65 | 51.7 | 0.31 | 2025-07-30 | 1 | 2 | NITRIC-OXIDE; COX-2; POLYPHENOLS; GINSENG; ROLES; INOS | antiinflammatory agent; cyclooxygenase 2; glyceraldehyde 3 phosphate dehydrogenase; immunoglobulin enhancer binding protein; inducible nitric oxide synthase; interleukin 1beta; interleukin 6; messenger RNA; mitogen activated protein kinase; nitric oxide; phellinus baumii extract; plant extract; tumor necrosis factor; unclassified drug; animal cell; antiinflammatory activity; Article; cell viability; cell viability assay; chemoluminescence; comparative study; down regulation; drug potency; enhanced chemiluminescence; Freund adjuvant-induced inflammation; gene expression; immunofluorescence assay; MH-S cell line; nonhuman; pathogenesis; Phellinus; Phellinus baumii; protein phosphorylation; real time polymerase chain reaction; reverse transcription polymerase chain reaction; signal transduction; traditional medicine; Western blotting | English | 2021 | 2021-10-25 | 10.1155/2021/5535630 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Review | Insights into hazardous solid waste generation during COVID-19 pandemic and sustainable management approaches for developing countries | The recent emergence of the COVID-19 pandemic has contributed to the drastic production and use of healthcare and personal protective equipment, leading to the release of a huge quantity of hazardous medical and solid wastes in the environment. Meanwhile, these solid wastes may contribute to the spread of the SARS-CoV-2 viral particles when disposed of without proper treatment and care. Since SARS-CoV-2 could persist on different material surfaces including plastic, steel, paper, cardboard, cloth, and wood, proper management of these hazardous solid wastes has become a challenging task during the COVID-19 pandemic. In this paper, an overview of the consumption of COVID-19-related healthcare and personal protective equipment along with the production of hazardous solid waste is presented. The efficient management of these wastes is necessary to prevent the entering of SARS-CoV-2 in various environmental compartments. Therefore, some preventive measures including the use of biodegradable materials for manufacturing personal protective equipment, minimizing the use of non-biodegradable materials, efficient pre- and-post planning, careful segregation, and disposal are, therefore, proposed for their sustainable management. The findings reported in this paper contribute to tackling the problems associated with hazardous solid waste management, particularly for low- and middle-income countries. | Adelodun, Bashir; Ajibade, Fidelis Odedishemi; Ibrahim, Rahmat Gbemisola; Ighalo, Joshua O.; Bakare, Hashim Olalekan; Kumar, Pankaj; Eid, Ebrahem M.; Kumar, Vinod; Odey, Golden; Choi, Kyung-Sook | Kyungpook Natl Univ, Dept Agr Civil Engn, Daegu, South Korea; Univ Ilorin, Dept Agr & Biosyst Engn, PMB 1515, Ilorin, Nigeria; Fed Univ Technol Akure, Dept Civil & Environm Engn, PMB 704, Akure, Nigeria; Chinese Acad Sci, Res Ctr Ecoenvironm Sci, Key Lab Environm Biotechnol, Beijing 100085, Peoples R China; Univ Chinese Acad Sci, Beijing 100049, Peoples R China; Kwara State Minist Hlth, Ilorin, Kwara, Nigeria; Univ Ilorin, Fac Engn & Technol, Dept Chem Engn, PMB 1515, Ilorin, Nigeria; Nnamdi Azikiwe Univ, Dept Chem Engn, PMB 5025, Awka, Nigeria; Gurukula Kangri Deemed Be Univ, Dept Zool & Environm Sci, Agroecol & Pollut Res Lab, Haridwar 249404, Uttarakhand, India; King Khalid Univ, Coll Sci, Biol Dept, Abha 61321, Saudi Arabia; Kafrelsheikh Univ, Fac Sci, Bot Dept, Kafr Al Sheikh 33516, Egypt; Natl Univ, Inst Agr Sci & Technol, Daegu, South Korea | Ighalo, Joshua/D-2551-2019; Kumar, Dr. Vinod/K-9971-2016; Eid, Ebrahem/O-2723-2013; Odey, Golden/MVV-6310-2025; Kumar, Vinod/V-8332-2019; Adelodun, Bashir/O-2941-2018; Ajibade, Fidelis/D-7893-2019; Kumar, Pankaj/AAF-2231-2019 | 57193774482; 57190341647; 57217480064; 57202955844; 57217480405; 57281192700; 35794350700; 57200152850; 57211444984; 54392662900 | adelodun.b@unilorin.edu.ng;ks.choi@knu.ac.kr; | JOURNAL OF MATERIAL CYCLES AND WASTE MANAGEMENT | J MATER CYCLES WASTE | 1438-4957 | 1611-8227 | 23 | 6 | SCIE | ENVIRONMENTAL SCIENCES | 2021 | 3.579 | 51.8 | 0.56 | 2025-07-30 | 35 | 43 | Coronavirus; COVID-19; Household waste; Medical waste; SARS-CoV-2; Waste management | DISPOSAL | Coronavirus; COVID-19; Household waste; Medical waste; SARS-CoV-2; Waste management | Developing Countries; Diseases; Hazards; Protective Clothing; Solid Wastes; Waste Management; Developing countries; Hazards; Health care; Protective clothing; Solid wastes; Sustainable development; Biodegradable material; Coronaviruses; Hazardous medical wastes; Hazardous solid waste; Household waste; Medical wastes; Personal protective equipment; Solid waste generation; Sustainable management; Viral particles; Coronavirus; COVID-19 | English | 2021 | 2021-11 | 10.1007/s10163-021-01281-w | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Postoperative results of ventilation tube insertion: a retrospective multicenter study for suggestion of grading system of otitis media with effusion | Background In otitis media with effusion (OME), it is important to know when to surgically intervene and when careful monitoring is more appropriate. This study aimed to visualize and classify the clinical manifestations of OME and the correlation between the new grading system and postoperative results after ventilation tube insertion (VTI). Methods We classified the collective 1,012 ears from 506 patients into six groups: grade 0 (no effusion), grade I (scant effusion, but abnormal), grade II (effusion less than half of the tympanic cavity), grade III (effusion over half of the tympanic cavity, with air bubbles), grade IV (complete effusion), and grade V (retracted tympanic membrane or hemotympanum without air bubbles). Results The mean age at VTI was 5.2 (+/- 2.9) years and mean duration between diagnosis and operation was 4.1 (+/- 1.8) months. Between the grades, the nature of the middle ear effusion was also significantly different (p < 0.001). The duration of ventilation tube retention after VTI was significantly different when compared between two groups: grade I-IV and grade V (p = 0.019). Our results showed that the recurrence rate, as well as rate of revision VTI, increased as the grade increased (p < 0.001). Conclusions The new grading system of OME using endoscopic otoscope evaluation had a significant correlation with the age at VTI, the nature of middle ear effusion, the recurrence rate of OME, and the rate of revision VTI. | Song, Chan Il; Kang, Byung Chul; Shin, Chol Ho; An, Yun Suk; Kim, Tae Su; Lim, Hyun Woo; Shim, Hyun Joon; Yoo, Myung Hoon; Ahn, Joong Ho | Yonsei Univ, Gangnam Severance Hosp, Dept Otorhinolaryngol, Coll Med, Seoul, South Korea; Univ Ulsan, Ulsan Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, Coll Med, Ulsan, South Korea; Univ Ulsan, Asan Med Ctr, Dept Otorhinolaryngol Head & Neck Surg, Coll Med, 88,Olymp Ro 43 Gil, Seoul 05505, South Korea; Bundang Jesaeng Gen Hosp, Daejin Med Ctr, Dept Otorhinolaryngol Head & Neck Surg, Seongnam, South Korea; Kangwon Natl Univ, Sch Med, Dept Otolaryngol, Chunchon, South Korea; Univ Ulsan, Gangneung Asan Hosp, Dept Otolaryngol, Coll Med, Kangnung, South Korea; Eulji Univ, Eulji Med Ctr, Dept Otorhinolaryngol Head & Neck Surg, Sch Med, Seoul, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Daegu, South Korea | ; CHANG, SUK WON/AFT-1073-2022; Lim, HW/GRY-3517-2022 | 56539126500; 7401684593; 57219172424; 35075759500; 57216858782; 8866988800; 35171593100; 22956750000; 55199119600 | meniere@amc.seoul.kr; | BMC PEDIATRICS | BMC PEDIATR | 1471-2431 | 21 | 1 | SCIE | PEDIATRICS | 2021 | 2.567 | 51.9 | 0.93 | 2025-07-30 | 9 | 7 | Otitis media with effusion; Ventilating tube; Endoscopic otoscope; Grade of effusion | CLINICAL-PRACTICE GUIDELINES; GENERAL-ANESTHESIA; EAR; CHILDREN; PATHOLOGY; HEARING | Endoscopic otoscope; Grade of effusion; Otitis media with effusion; Ventilating tube | Humans; Infant; Middle Ear Ventilation; Otitis Media with Effusion; Postoperative Period; Recurrence; Retrospective Studies; adenoidectomy; Article; child; clinical decision making; comparative study; controlled study; disease classification; disease course; ear disease; eardrum; endoscopy; female; groups by age; hemotympanum; human; major clinical study; male; multicenter study; operation duration; otorrhea; patient coding; postoperative period; prediction; recurrence risk; reoperation; retrospective study; school child; secretory otitis media; clinical trial; infant; middle ear ventilation; postoperative period; recurrent disease; secretory otitis media | English | 2021 | 2021-08-31 | 10.1186/s12887-021-02855-1 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Ultra-deep sequencing mutation analysis of the BCR/ABL1 kinase domain in newly diagnosed chronic myeloid leukemia patients | Ultra deep sequencing detects low-frequency genetic mutations with high sensitivity. We used this approach to prospectively examine mutations in the BCR/ABL1 tyrosine kinase from patients with newly diagnosed, chronicphase chronic myeloid leukemia (CML) treated with the tyrosine kinase inhibitor nilotinib. Between May 2013 and November 2014, 50 patients from 18 institutions were enrolled in the study. We screened 103 somatic mutations and found that mutations in the P-loop domain were the most frequent (173/454 mutations in the Ploop) and noted the presence of the V299 L mutation (dasatinib-resistant/nilotinib-sensitive) in 98 % of patients (49/50). No patients had Y253H, E255 V, or F359 V/C/I mutations, which would recommend dasatinib rather than nilotinib treatment. The S417Y mutation was associated with lower achievement of a major molecular response (MMR) at 6 months, and the V371A mutation was associated with reduced MMR and MR4.5 durations (MMR for 2 years: 100 % for no mutation vs. 75 % for mutation, P=0.039; MR4.5 for 15 months: 94.1 % vs. 25 %, P=0.002). Patients with known nilotinib-resistant mutations had lower rates of MR4.5 achievement. In conclusion, ultra-deep sequencing is a sensitive method for genetic-based treatment decisions. Based on the results of these mutational analyses, nilotinib treatment is a promising option for Korean patients with CML. | Park, Hyunkyung; Kim, Inho; Kim, Hyeong-Joon; Shin, Dong-Yeop; Lee, Sung-Yeoun; Kwon, Oh-Hyung; Kim, Dae-Young; Lee, Kyoo-Hyung; Ahn, Jae-Sook; Park, Jinny; Sohn, Sang-Kyun; Lee, Jeong-Ok; Cheong, June-Won; Kim, Kyoung Ha; Kim, Hoon-Gu; Kim, Hawk; Lee, Yoo Jin; Nam, Seung-Hyun; Do, Young Rok; Park, Sang-Gon; Park, Seong Kyu; Bae, Sung Hwa; Song, Hun Ho; Oh, Doyeun; Jung, Chul Won; Park, Seonyang | Seoul Natl Univ, Seoul Natl Univ Hosp, Biomed Res Inst, Canc Res Inst,Dept Internal Med,Coll Med, Seoul, South Korea; Seoul Natl Univ, Dept Internal Med, Seoul Metropolitan Govt, Borarnae Med Ctr, Seoul, South Korea; Chonnam Natl Univ, Hwasun Hosp, Dept Internal Med, Hwasun, South Korea; LAS Inc, Gimpo, South Korea; Univ Ulsan, Asan Med Ctr, Dept Internal Med, Coll Med, Seoul, South Korea; Gachon Univ, Dept Internal Med, Gil Med Ctr, Incheon, South Korea; Kyungpook Natl Univ Hosp, Dept Internal Med, Daegu, South Korea; Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Seongnam, South Korea; Yonsei Univ, Severance Hosp, Dept Internal Med, Seoul, South Korea; Soonchunhyang Univ, Dept Internal Med, Seoul Hosp, Seoul, South Korea; Gyeongsang Natl Univ, Gyeongsang Inst Hlth Sci, Dept Internal Med, Coll Med, Chang Won, South Korea; Gyeongsang Natl Univ, Changwon Hosp, Chang Won, South Korea; Ulsan Univ Hosp, Dept Internal Med, Ulsan, South Korea; VHS Med Ctr, Dept Internal Med, Seoul, South Korea; Keimyung Univ, Dept Internal Med, Dongsan Med Ctr, Daegu, South Korea; Chosun Univ Hosp, Dept Internal Med, Gwangju, South Korea; Soonchunhyang Univ, Dept Internal Med, Bucheon Hosp, Bucheon, South Korea; Daegu Catholic Univ, Dept Internal Med, Med Ctr, Daegu, South Korea; Kangdong Sacred Heart Hosp, Dept Internal Med, Seoul, South Korea; CHA Bundang Med Ctr, Dept Internal Med, Seongnam, South Korea; Samsung Med Ctr, Dept Internal Med, Seoul, South Korea; Inje Univ, Haeundae Paik Hosp, Dept Internal Med, Busan, South Korea | ; Kim, Tae/B-9921-2013; Hyun-Jung, Kim/E-8074-2011; Lee, Sungyeoun/ACR-8079-2022; Park, M.J./Y-5611-2019; Park, Jung Hyun/HJA-3755-2022; Lee, Jung-Hye/F-6974-2013; Park, Jinwoo/AAD-1328-2022; Kim, Il Young/LLK-4732-2024; Lee, Jong-Seok/J-5603-2012 | 57203771773; 55712969800; 7410127473; 36492559200; 57295837100; 57297088400; 56955900700; 38163134100; 22984055900; 35277336100; 13310226800; 40361307900; 7004933294; 7409319096; 35230023400; 57218435122; 57188669696; 55264192100; 8960168300; 42962202500; 57077159400; 56545017400; 7404037551; 7203001784; 56405934800; 57049842400 | ihkimmd@snu.ac.kr;hjoonk@chonnam.ac.kr; | LEUKEMIA RESEARCH | LEUKEMIA RES | 0145-2126 | 1873-5835 | 111 | SCIE | HEMATOLOGY;ONCOLOGY | 2021 | 3.715 | 51.9 | 0.06 | 2025-07-30 | 2 | 2 | Chronic myeloid leukemia; BCR-ABL1 tyrosine kinase; Mutations; Molecular response; Ultra-deep sequencing | BCR-ABL MUTATIONS; CELL-FREE DNA; IMATINIB RESISTANCE; INHIBITORS; SURVIVAL; RECOMMENDATIONS; FRAMEWORK; SCORE; CML | BCR-ABL1 tyrosine kinase; Chronic myeloid leukemia; Molecular response; Mutations; Ultra-deep sequencing | Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Dasatinib; Drug Resistance, Neoplasm; Female; Follow-Up Studies; Fusion Proteins, bcr-abl; High-Throughput Nucleotide Sequencing; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; Mutation; Prognosis; Prospective Studies; Pyrimidines; Survival Rate; BCR ABL protein; dasatinib; nilotinib; 4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide; antineoplastic agent; BCR ABL protein; dasatinib; pyrimidine derivative; tumor marker; adult; Article; BCR ABL1 gene; cancer chemotherapy; cancer resistance; chemosensitivity; chronic myeloid leukemia; clinical article; drug effect; female; gene mutation; human; male; mutational analysis; mutator gene; somatic mutation; treatment outcome; treatment planning; chronic myeloid leukemia; drug resistance; follow up; genetics; high throughput sequencing; middle aged; mutation; pathology; prognosis; prospective study; survival rate | English | 2021 | 2021-12 | 10.1016/j.leukres.2021.106728 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Anticancer effects and potential mechanisms of ginsenoside Rh2 in various cancer types | Ginsenoside Rh2 (G-Rh2) is a natural bioactive product derived from Panax ginseng Meyer (P. ginseng). G-Rh2 exhibits anticancer activity in various human cancer cell lines both in vitro and in vivo by modulating several signaling pathways, such as those of PDZ-binding kinase/T-LAK cell-originated protein kinase, phosphatidylinositol 3-kinase, protein kinase B, mammalian target of rapamycin, epidermal growth factor receptor, p53, and reactive oxygen species. Moreover, G-Rh2 could effectively reverse drug resistance and enhance therapeutic effects in cancer therapy. This review summarizes the chemical properties, in vitro and in vivo anticancer activity, and underlying molecular mechanisms of G-Rh2 to facilitate cancer chemoprevention studies. | Zhang, Haibo; Park, Song; Huang, Hai; Kim, Eungyung; Yi, Junkoo; Choi, Seong-Kyoon; Ryoo, Zaeyoung; Kim, Myoungok | Kyungpook Natl Univ, Inst Translat Res Dent, Dept Anim Sci & Biotechnol, 80 Daehakro, Bukgu 41566, Daegu, South Korea; Daegu Gyeongbuk Inst Sci & Technol, Core Prot Resources Ctr, Daegu 41566, South Korea; Gyeongsangbukdo Livestock Inst Res, Yeongju 36052, Gyeongsangbukdo, South Korea; Kyungpook Natl Univ, Brain Korea 21 Fostering Outstanding Univ Res Kyu, Sch Life Sci, 80 Daehakro, Daegu 41566, South Korea | Zhang, Haibo/HLP-9266-2023; Yi, Junkoo/JBR-8507-2023 | 57221648126; 57139047900; 57215021952; 57217871658; 56182537200; 55505432500; 16937104900; 8934745900 | jaewoong64@hanmail.net;ok4325@knu.ac.kr; | ONCOLOGY REPORTS | ONCOL REP | 1021-335X | 1791-2431 | 45 | 4 | SCIE | ONCOLOGY | 2021 | 4.136 | 52.0 | 1.15 | 2025-07-30 | 33 | 39 | ginsenoside Rh2; Panax ginseng; anticancer; mechanisms; review | CELL-CYCLE ARREST; HUMAN LEUKEMIA-CELLS; 20(S)-GINSENOSIDE RH2; CARCINOMA-CELLS; MOLECULAR-MECHANISMS; LUNG-CANCER; GLIOBLASTOMA-MULTIFORME; ADJUVANT CHEMOTHERAPY; DEPENDENT INHIBITION; HISTONE DEACETYLASE | Anticancer; Ginsenoside Rh2; Mechanisms; Panax ginseng; Review | Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Ginsenosides; Humans; Neoplasms; Panax; Signal Transduction; caspase 3; collagenase 3; cyclin dependent kinase inhibitor 2A; cyclin dependent kinase inhibitor 2B; cytochrome c; epidermal growth factor receptor; gelatinase A; ginsenoside Rh 2; interleukin 1beta converting enzyme; lysosome associated membrane protein 2; mammalian target of rapamycin; microRNA; microRNA 128; phosphatidylinositol 3 kinase; programmed death 1 ligand 1; protein Bax; protein kinase B; reactive oxygen metabolite; stromelysin; transforming growth factor beta; unclassified drug; vasculotropin; antineoplastic agent; ginsenoside; ginsenoside Rh 2; acute lymphoblastic leukemia; antiangiogenic activity; antineoplastic activity; apoptosis; autophagy (cellular); cancer cell line; cell cycle arrest; cell proliferation; colon cancer; down regulation; drug mechanism; drug resistance; drug structure; human; leukemia; liver cancer; lung cancer; malignant neoplasm; nonhuman; ovary cancer; prostate cancer; protein expression; Review; signal transduction; tumor immunity; tumor xenograft; upregulation; chemistry; drug effect; neoplasm; Panax; pathology; tumor cell line | English | 2021 | 2021-04 | 10.3892/or.2021.7984 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Meeting Abstract | Metabolic Functions of Adipose SIRT1 | Zhang, Pengcheng; Konja, Daniels; Zhang, Yiwei; Xu, Aimin; Lee, In-Kyu; Jeon, Jae-Han; Bashiri, Ghader; Mitra, Alok; Wang, Yu | Univ Hong Kong, State Key Lab Pharmaceut Biotechnol, Hong Kong, Peoples R China; Univ Hong Kong, Dept Pharmacol & Pharm, Hong Kong, Peoples R China; Univ Hong Kong, Dept Med, Hong Kong, Peoples R China; Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Res Inst Aging & Metab, Daegu 41404, South Korea; Univ Auckland, Sch Biol Sci, Auckland, New Zealand | Wang, Yu/B-4534-2009; Lee, In-Kyu/AAR-6374-2021 | JOURNAL OF CARDIOVASCULAR PHARMACOLOGY | J CARDIOVASC PHARM | 0160-2446 | 1533-4023 | 78 | SCIE | CARDIAC & CARDIOVASCULAR SYSTEMS;PHARMACOLOGY & PHARMACY | 2021 | 3.271 | 52.1 | 0 | English | 2021 | 2021-12 | 바로가기 | 바로가기 | ||||||||||||||||
| ○ | ○ | Article | Sensor fusion of two sonar devices for underwater 3D mapping with an AUV | We present herein a three-dimensional (3D) mapping method in one-way rectilinear scanning with an autonomous underwater vehicle (AUV) equipped with a forward looking sonar (FLS) and a profiling sonar (PS). Three-dimensional reconstruction using sonar with a finite beam width is an ill-posed problem, and additional constraints also need to be considered. Our approach involves an additional sonar and fuse acoustic measurements provided by the two sonar sensors. The FLS has a high resolution in the horizontal scan but has a uncertainty in the vertical scan. Meanwhile, the PS provides a reliable vertical profile, but its beam width is extremely narrow. An initial map is generated by the FLS and refined by combining the PS vertical scan data. To demonstrate the validity and effectiveness of the proposed method, we conducted tests in a water tank and also at sea. Finally, we presented the results of the proposed method gathered by an AUV in the tests. | Joe, Hangil; Cho, Hyeonwoo; Sung, Minsung; Kim, Jinwhan; Yu, Son-cheol | Kyungpook Natl Univ, Dept Robot & Smart Syst Engn, Daegu, South Korea; POSTECH, Dept Creat IT Engn, Pohang, South Korea; Korea Adv Inst Sci & Technol, Dept Mech Engn, Daejeon, South Korea | Kim, JinWhan/C-1807-2011; Joe, Hangil/LOR-9635-2024 | 55848385500; 23102090500; 57192577834; 54946579500; 8712522100 | hgjoe@knu.ac.kr;lighto@postech.ac.kr;ms.sung@postech.ac.kr;jinwhan@kaist.ac.kr;sncyu@postech.ac.kr; | AUTONOMOUS ROBOTS | AUTON ROBOT | 0929-5593 | 1573-7527 | 45 | 4 | SCIE | COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE;ROBOTICS | 2021 | 3.255 | 52.1 | 1.1 | 2025-07-30 | 25 | 29 | Sensor fusion; Autonomous underwater vehicle; 3D reconstruction; Underwater mapping; Forward looking sonar; Profiling sonar | 3D reconstruction; Autonomous underwater vehicle; Forward looking sonar; Profiling sonar; Sensor fusion; Underwater mapping | Agricultural robots; Mapping; Sonar; Underwater acoustic communication; Water tanks; Acoustic measurements; Autonomous underwater vehicles (AUV); Forward looking sonars; Ill posed problem; Three-dimensional reconstruction; Threedimensional (3-d); Two sonar sensors; Vertical profile; Autonomous underwater vehicles | English | 2021 | 2021-05 | 10.1007/s10514-021-09986-5 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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