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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ○ | ○ | Review | Strong interaction physics at the luminosity frontier with 22 GeV electrons at Jefferson Lab | Accardi, A.; Achenbach, P.; Adhikari, D.; Afanasev, A.; Akondi, C. S.; Akopov, N.; Albaladejo, M.; Albataineh, H.; Albrecht, M.; Almeida-Zamora, B.; Amaryan, M.; Androic, D.; Armstrong, W.; Armstrong, D. S.; Arratia, M.; Arrington, J.; Asaturyan, A.; Austregesilo, A.; Avakian, H.; Averett, T.; Gayoso, C. Ayerbe; Bacchetta, A.; Balantekin, A. B.; Baltzell, N.; Barion, L.; Barry, P. C.; Bashir, A.; Battaglieri, M.; Bellini, V; Belov, I; Benhar, O.; Benkel, B.; Benmokhtar, F.; Bentz, W.; Bertone, V; Bhatt, H.; Bianconi, A.; Bibrzycki, L.; Bijker, R.; Binosi, D.; Biswas, D.; Boer, M.; Boeglin, W.; Bogacz, S. A.; Boglione, M.; Bondi, M.; Boos, E. E.; Bosted, P.; Bozzi, G.; Brash, E. J.; Briceno, R. A.; Brindza, P. D.; Briscoe, W. J.; Brodsky, S. J.; Brooks, W. K.; Burkert, V. D.; Camsonne, A.; Cao, T.; Cardman, L. S.; Carman, D. S.; Carpinelli, M.; Cates, G. D.; Caylor, J.; Celentano, A.; Celiberto, F. G.; Cerutti, M.; Chang, L.; Chatagnon, P.; Chen, C.; Chen, J-P; Chetry, T.; Christopher, A.; Christy, E.; Chudakov, E.; Cisbani, E.; Cloet, I. C.; Cobos-Martinez, J. J.; Cohen, E. O.; Colangelo, P.; Cole, P. L.; Constantinou, M.; Contalbrigo, M.; Costantini, G.; Cosyn, W.; Cotton, C.; Courtoy, A.; Dusa, S. Covrig; Crede, V; Cui, Z-F; D'Angelo, A.; Doring, M.; Dalton, M. M.; Danilkin, I; Davydov, M.; Day, D.; De Fazio, F.; De Napoli, M.; De Vita, R.; Dean, D. J.; Defurne, M.; de Paula, W.; de Teramond, G. F.; Deur, A.; Devkota, B.; Dhital, S.; Di Nezza, P.; Diefenthaler, M.; Diehl, S.; Dilks, C.; Ding, M.; Djalali, C.; Dobbs, S.; Dupre, R.; Dutta, D.; Edwards, R. G.; Egiyan, H.; Ehinger, L.; Eichmann, G.; Elaasar, M.; Elouadrhiri, L.; El Alaoui, A.; El Fassi, L.; Emmert, A.; Engelhardt, M.; Ent, R.; Ernst, D. J.; Eugenio, P.; Evans, G.; Fanelli, C.; Fegan, S.; Fernandez-Ramirez, C.; Fernandez, L. A.; Fernando, I. P.; Filippi, A.; Fischer, C. S.; Fogler, C.; Fomin, N.; Frankfurt, L.; Frederico, T.; Freese, A.; Fu, Y.; Gamberg, L.; Gan, L.; Gao, F.; Garcia-Tecocoatzi, H.; Gaskell, D.; Gasparian, A.; Gates, K.; Gavalian, G.; Ghoshal, P. K.; Giachino, A.; Giacosa, F.; Giannuzzi, F.; Gilfoyle, G-P; Girod, F-X; Glazier, D., I; Gleason, C.; Godfrey, S.; Goity, J. L.; Golubenko, A. A.; Gonzalez-Solis, S.; Gothe, R. W.; Gotra, Y.; Griffioen, K.; Grocholski, O.; Grube, B.; Gueye, P.; Guo, F-K; Guo, Y.; Guo, L.; Hague, T. J.; Hammoud, N.; Hansen, J-O; Hattawy, M.; Hauenstein, F.; Hayward, T.; Heddle, D.; Heinrich, N.; Hen, O.; Higinbotham, D. W.; Higuera-Angulo, I. M.; Blin, A. N. Hiller; Hobart, A.; Hobbs, T.; Holmberg, D. E.; Horn, T.; Hoyer, P.; Huber, G. M.; Hurck, P.; Hutauruk, P. T. P.; Ilieva, Y.; Illari, I.; Ireland, D. G.; Isupov, E. L.; Italiano, A.; Jaegle, I; Jarvis, N. S.; Jenkins, D. J.; Jeschonnek, S.; Ji, C-R; Jo, H. S.; Jones, M.; Jones, R. T.; Jones, D. C.; Joo, K.; Junaid, M.; Kageya, T.; Kalantarians, N.; Karki, A.; Karyan, G.; Katramatou, A. T.; Kay, S. J. D.; Kazimi, R.; Keith, C. D.; Keppel, C.; Kerbizi, A.; Khachatryan, V; Khanal, A.; Khandaker, M.; Kim, A.; Kinney, E. R.; Kohl, M.; Kotzinian, A.; Kriesten, B. T.; Kubarovsky, V; Kubis, B.; Kuhn, S. E.; Kumar, V; Kutz, T.; Leali, M.; Lebed, R. F.; Lenisa, P.; Leskovec, L.; Li, S.; Li, X.; Liao, J.; Lin, H-W; Liu, L.; Liuti, S.; Liyanage, N.; Lu, Y.; MacGregor, I. J. D.; Mack, D. J.; Maiani, L.; Mamo, K. A.; Mandaglio, G.; Mariani, C.; Markowitz, P.; Marukyan, H.; Mascagna, V; Mathieu, V; Maxwell, J.; Mazouz, M.; McCaughan, M.; McKeown, R. D.; McKinnon, B.; Meekins, D.; Melnitchouk, W.; Metz, A.; Meyer, C. A.; Meziani, Z-E; Mezrag, C.; Michaels, R.; Miller, G. A.; Mineeva, T.; Miramontes, A. S.; Mirazita, M.; Mizutani, K.; Mkrtchyan, A.; Mkrtchyan, H.; Moffit, B.; Mohanmurthy, P.; Mokeev, V., I; Monaghan, P.; Montana, G.; Montgomery, R.; Moretti, A.; Chavez, J. M. Morgado; Mosel, U.; Movsisyan, A.; Musico, P.; Nadeeshani, S. A.; Nadolsky, P. M.; Nakamura, S. X.; Nazeer, J.; Nefediev, A., V; Neupane, K.; Nguyen, D.; Niccolai, S.; Niculescu, I; Niculescu, G.; Nocera, E. R.; Nycz, M.; Olness, F., I; Ortega, P. G.; Osipenko, M.; Pace, E.; Pandey, B.; Pandey, P.; Papandreou, Z.; Papavassiliou, J.; Pappalardo, L. L.; Paredes-Torres, G.; Paremuzyan, R.; Park, S.; Parsamyan, B.; Paschke, K. D.; Pasquini, B.; Passemar, E.; Pasyuk, E.; Patel, T.; Paudel, C.; Paul, S. J.; Peng, J-C; Pentchev, L.; Perrino, R.; Perry, R. J.; Peters, K.; Petratos, G. G.; Phelps, W.; Piasetzky, E.; Pilloni, A.; Pire, B.; Pitonyak, D.; Pitt, M. L.; Polosa, A. D.; Pospelov, M.; Postuma, A. C.; Poudel, J.; Preet, L.; Prelovsek, S.; Price, J. W.; Prokudin, A.; Puckett, A. J. R.; Pybus, J. R.; Qin, S-X; Qiu, J-W; Radici, M.; Rashidi, H.; Rathnayake, A. D.; Raue, B. A.; Reed, T.; Reimer, P. E.; Reinhold, J.; Richard, J-M; Rinaldi, M.; Ringer, F.; Ripani, M.; Ritman, J.; West, J. Rittenhouse; Rivero-Acosta, A.; Roberts, C. D.; Rodas, A.; Rodini, S.; Rodriguez-Quintero, J.; Rogers, T. C.; Rojo, J.; Rossi, P.; Rossi, G. C.; Salme, G.; Santiesteban, S. N.; Santopinto, E.; Sargsian, M.; Sato, N.; Schadmand, S.; Schmidt, A.; Schmidt, S. M.; Schnell, G.; Schumacher, R. A.; Schweitzer, P.; Scimemi, I; Scott, K. C.; Seay, D. A.; Segovia, J.; Semenov-Tian-Shansky, K.; Seryi, A.; Sharda, A. S.; Shepherd, M. R.; Shirokov, E., V; Shrestha, S.; Shrestha, U.; Shvedunov, V., I; Signori, A.; Slifer, K. J.; Smith, W. A.; Somov, A.; Souder, P.; Sparveris, N.; Spizzo, F.; Spreafico, M.; Stepanyan, S.; Stevens, J. R.; Strakovsky, I. I.; Strauch, S.; Strikman, M.; Su, S.; Sumner, B. C. L.; Sun, E.; Suresh, M.; Sutera, C.; Swanson, E. S.; Szczepaniak, A. P.; Sznajder, P.; Szumila-Vance, H.; Szymanowski, L.; Tadepalli, A-S; Tadevosyan, V; Tamang, B.; Tarasov, V. V.; Thiel, A.; Tong, X-B; Tyson, R.; Ungaro, M.; Urciuoli, G. M.; Usman, A.; Valcarce, A.; Vallarino, S.; Vaquera-Araujo, C. A.; Venturelli, L.; Vera, F.; Vladimirov, A.; Vossen, A.; Wagner, J.; Wei, X.; Weinstein, L. B.; Weiss, C.; Williams, R.; Winney, D.; Wojtsekhowski, B.; Wood, M. H.; Xiao, T.; Xu, S-S; Ye, Z.; Yero, C.; Yuan, C-P; Yurov, M.; Zachariou, N.; Zhang, Z.; Zhao, Y.; Zhao, Z. W.; Zheng, X.; Zhou, X.; Ziegler, V; Zihlmann, B. | Hampton Univ, Hampton, VA 23669 USA; Thomas Jefferson Natl Accelerator Facil, Newport News, VA 23606 USA; Virginia Tech, Blacksburg, VA 24061 USA; George Washington Univ, Washington, DC 20052 USA; Florida State Univ, Tallahassee, FL 32306 USA; Yerevan Phys Inst, AI Alikhanyan Natl Sci Lab, Yerevan 0036, Armenia; Ctr Mixto CSIC Univ Valencia, Inst Fis Corpuscular IFIC, Valencia 46071, Spain; Texas A&M Univ Kingsville, Kingsville, TX 78363 USA; Univ Sonora, Colonia Ctr, Dept Invest Fis, Blvd Luis Encinas J y Rosales, Hermosillo 83000, Sonora, Mexico; Old Dominion Univ, Norfolk, VA 23529 USA; Univ Zagreb, Zagreb 10000, Croatia; Argonne Natl Lab, Lemont, IL 60439 USA; Coll William & Mary, Williamsburg, VA 23187 USA; Univ Calif Riverside, Riverside, CA 92521 USA; Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA; Univ North Carolina Wilmington, Wilmington, NC 28403 USA; Univ Pavia, I-27100 Pavia, Italy; Ist Nazl Fis Nucl, I-27100 Pavia, Italy; 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Univ Cagliari, I-09042 Monserrato, CA, Italy; Ist Nazl Fis Nucl, Sez Cagliari, I-09042 Monserrato, CA, Italy; Christopher Newport Univ, Newport News, VA 23606 USA; Univ Calif Berkeley, Berkeley, CA 94720 USA; SLAC Natl Accelerator Lab, Menlo Pk, CA 94025 USA; Ctr Sci & Technol Valparaiso 699, Valparaiso, Chile; SAPHIR Millennium Sci Inst, Santiago, Chile; Univ Milano Bicocca, I-20126 Milan, Italy; Univ Virginia, Charlottesville, VA 22904 USA; Univ Alcala UAH, Dept Fis & Matemat, Campus Univ, Madrid 28805, Spain; Nankai Univ, Tianjin 300071, Peoples R China; Peng Huanwu Ctr Fundamental Theory, Hefei 230026, Anhui, Peoples R China; Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China; Univ Sonora, Colonia Ctr, Dept Fis, Blvd Luis Encinas J & Rosales, Hermosillo 83000, Sonora, Mexico; Tel Aviv Univ, IL-6927845 Tel Aviv, Israel; Nucl Res Ctr Negev, IL-84190 Beer Sheva, Israel; Ist Nazl Fis Nucl, Sez Bari, I-70125 Bari, Italy; Lamar Univ, Beaumont, TX 77710 USA; Temple Univ, Philadelphia, PA 19122 USA; 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Univ Complutense Madrid, IPARCOS, Plaza Ciencias 1, Madrid 28040, Spain; Univ Pablo de Olavide, Dept Sistemas Fis Quim & Nat, Seville 41013, Spain; Syracuse Univ, Syracuse, NY 13244 USA; Univ Genoa, I-16126 Genoa, Italy; Penn State Univ, University Pk, PA 16802 USA; Univ Arizona, Tucson, AZ 85721 USA; Univ Pittsburgh, Pittsburgh, PA 15206 USA; NCBJ, Natl Ctr Nucl Res, PL-02093 Warsaw, Poland; Natl Res Ctr, Kurchatov Inst, Moscow 123182, Russia; Chinese Univ Hong Kong, Shenzhen 518172, Guangdong, Peoples R China; Ist Nazl Fis Nucl, Sez Roma, I-00185 Rome, Italy; Consejo Nacl Ciencia & Technol, Av Insurgentes Sur 1582, Ciudad De Mexico 03940, Mexico; Dual CP Inst High Energy Phys, Colima 28045, Mexico; South China Normal Univ, Guangzhou 510006, Peoples R China; Canisius Coll, Buffalo, NY 14208 USA; Univ North Texas, Denton, TX 76201 USA; Nanjing Univ Posts & Telecommun, Nanjing 210023, Peoples R China; Tsinghua Univ, Beijing 100084, Peoples R China; Wuhan Univ, Wuhan 430072, Hubei, Peoples R China; Univ Costa Rica, Lab Fis Teor & Computac, San Jose 11501, Costa Rica; Univ Nacl Autonoma Mexico, Inst Fis, Apartado Postal 20-364, Ciudad De Mexico 01000, Mexico | Albaladejo, Miguel/AAA-9482-2020; M, Suresh/LTF-0238-2024; Parsamyan, Bakur/AAB-5049-2019; Costantini, Giulio/F-3829-2018; Perrino, Roberto/KRP-0849-2024; Pilloni, Alessandro/M-3626-2014; Alaoui, Ahmed/B-4638-2015; Austregesilo, Alexander/HKW-1015-2023; Moretti, Alessia/N-3896-2019; Ye, Zhihong/E-6651-2017; Mathieu, Vincent/N-9218-2018; Meyer, Curtis/L-3488-2014; Pasquini, Barbara/J-5705-2019; McKinnon, Bryan/J-2928-2018; de paula, wayne/E-6414-2011; Bibrzycki, Łukasz/AHA-7213-2022; Reimer, Paul E/E-2223-2013; Rodini, Simone/CAH-6745-2022; Vaquera-Araujo, Carlos Alberto/I-2946-2015; Deur, Alexandre/H-9778-2019; Bozzi, Giuseppe/H-7283-2017; Rojo, Juan/B-4332-2018; Huber, Garth/JNS-0022-2023; Achenbach, Patrick/AAB-4394-2020; Tong, Xuan-Bo/HTM-7409-2023; MacGregor, Ian/D-4072-2011; Pappalardo, Luciano/AAB-2380-2021; Cates, Gordon/HQY-5058-2023; Garcia Tecocoatzi, Hugo/ABD-9615-2021; Vladimirov, Alexey/AFS-1287-2022; Osipenko, Mikhail/N-8292-2015; Xu, Shu-Sheng/AAD-6944-2019; MohanMurthy, Prajwal/AAF-1449-2019; Celiberto, Francesco Giovanni/ABF-5841-2020; Zheng, Xiaochao/LZH-2152-2025; Paschke, Kent/JCE-3864-2023; Jarvis, Naomi/D-5432-2015; Valcarce, Alfredo/AAD-8004-2020; Bashir, Adnan/X-5561-2018; Nocera, Emanuele Roberto/HLV-7826-2023; Bacchetta, Alessandro/F-3199-2012; Guo, Feng-Kun/F-5325-2010; Isupov, Evgeny/J-2976-2012; BELLINI, Vincenzo/B-1239-2012; Androić, Darko/A-7482-2008; Qin, Si-xue/W-2475-2019; Adhikari, Devi/GLV-5138-2022; Leskovec, Luka/AFV-9572-2022; Mariani, Camillo/J-6070-2015; Markowitz, Pete/AAC-3382-2020; Mascagna, Valerio/HLQ-1103-2023; Ji, Chueng/J-2623-2013; Hutauruk, Parada/AAT-1877-2021; Fernández Ramírez, César/E-9213-2010; Peng, Jingchao/JGD-2562-2023; Albataineh, Hisham/HRD-8213-2023; Montana, Gloria/ABC-6192-2020; Kotzinian, Aram/L-2485-2019; Chen, Chen/AAJ-7130-2021; Mineeva, Taisiya/MDT-1592-2025; Pandey, Biswajit/AAT-3995-2020; Ding, Minghui/HJZ-3698-2023; Santopinto, Elena/AGO-8650-2022; Celentano, Andrea/JFJ-2728-2023; Sparveris, Nikolaos/C-4751-2008; Segovia, Jorge/C-7202-2015; Tarasov, Victor/HSG-8287-2023; Zhao, Zhi-Wen/HZI-5398-2023; Balantekin, Akif/E-4776-2010; Garcia Ortega, Pablo/G-5155-2014; Rodriguez-Quintero, Jose/L-3229-2014; De Fazio, Fulvia/JCO-4378-2023; Courtoy, Aurore/GRY-7619-2022; Schumacher, Reinhard/K-6455-2013; Ortega, Pablo/G-5155-2014; Brooks, William/C-8636-2013; Nefediev, Alexey/A-8263-2016; Giannuzzi, Floriana/LDF-8406-2024; Spizzo, Federico/J-8140-2014; Khanal, Aaditya/ABI-5610-2020; D'Angelo, Annalisa/A-2439-2012; Eichmann, Gernot/AAM-2607-2021; Higinbotham, Douglas/J-9394-2014; Kerbizi, Albi/LJL-0302-2024; Miramontes, Angel/NGS-8024-2025; Morgado Chávez, Jose/AAX-5931-2020; CUI, Zhu-Fang/A-1394-2015; Fernando, Ishara/JYO-9732-2024; Burkert, Volker/AAF-7395-2020; Stevens, Jennifer/JWO-1611-2024; Giachino, Alessandro/LKO-2151-2024; Battaglieri, Marco/I-6262-2018; Tyson, Richard/LRC-4125-2024; Marukyan, Hrachya/JMQ-7949-2023; Jo, Hyon-Suk/HGC-7070-2022; CUI, Zhu-Fang/AAR-8355-2021; Dalton, Mark/B-5380-2016; Ireland, David/E-8618-2010; Akondi, Chandrasekhar/IUN-6272-2023; POUDEL, JIWAN/KQU-6557-2024; Binosi, Daniele/G-8160-2012; Frederico, Tobias/ABH-1785-2021; Reimer, Paul/E-2223-2013; Brodsky, Stanley/AAF-7637-2020 | 7004351781; 7004424420; 57222310465; 7003494602; 56423766100; 7004430681; 25927800300; 55285589800; 56523996600; 57670061300; 35277104000; 6603064352; 57221249616; 7404406991; 55087161000; 57206493481; 23567808500; 35483003600; 7006613415; 7004322920; 57219641026; 7004059162; 7004112355; 35226938500; 23033257000; 57204187814; 55993720600; 7004520678; 7006066441; 57207932276; 7003900149; 57605743600; 57218527298; 56076480800; 37065739800; 57208100224; 7102358422; 8404107200; 7003802851; 55913886000; 58948022700; 57193903188; 57218357388; 7004429063; 6701319923; 54398256600; 35351385500; 35404427600; 6701441101; 6603774294; 54958717100; 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8721812700; 7201653195; 7102806030; 6603421128; 58630228900; 58476341200; 23767613200; 12244533300; 6601981516; 58475880800; 35227973700; 15030349100; 57218279069; 57213706614; 7004828615; 56070212700; 7003298969; 57395061100; 56328779500; 6603693270; 6507906118; 6603929802; 57221112096; 7004491103; 57216999166; 22969481600; 7004321986; 7006704508; 59546748100; 57219839941; 32467452600; 57224851680; 59827713100; 7101660574; 57203070364; 54882337500; 57193416688; 56212534100; 55248155700; 6602934334; 58476808600; 7202005619; 36483487200; 57211682186; 57222078258; 35228099400; 57201276727; 57452408400; 7003432048; 57223798916; 22836713300; 22136651400; 57204000493; 7102276477; 36934412800; 57199776789; 13204321200; 35377851100; 57202422672; 58422408300; 57211078940; 6701552350; 57201559118; 58710841300; 56542148500; 56768650000; 57207251221; 57201192193; 16029849600; 36836386600; 58392800500; 55351893900; 57216598335; 57216598726; 55437341800; 59819934500; 6701379510 | rossi@jlab.org; | EUROPEAN PHYSICAL JOURNAL A | EUR PHYS J A | 1434-6001 | 1434-601X | 60 | 9 | SCIE | PHYSICS, NUCLEAR;PHYSICS, PARTICLES & FIELDS | 2024 | 2.8 | 38.6 | 3.93 | 2025-05-07 | 28 | 29 | DEEP-INELASTIC SCATTERING; LEADING NEUTRON-PRODUCTION; SHORT-RANGE CORRELATIONS; QUARK-GLUON PLASMA; PB-PB COLLISIONS; COLOR-TRANSPARENCY; NUCLEAR TRANSPARENCY; CURRENT-ALGEBRA; PRECISION-MEASUREMENT; PARTON DISTRIBUTIONS | English | 2024 | 2024-09-04 | 10.1140/epja/s10050-024-01282-x | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Alterations in Plasma Lipid Profile before and after Surgical Removal of Soft Tissue Sarcoma | Soft tissue sarcoma (STS) is a relatively rare malignancy, accounting for about 1% of all adult cancers. It is known to have more than 70 subtypes. Its rarity, coupled with its various subtypes, makes early diagnosis challenging. The current standard treatment for STS is surgical removal. To identify the prognosis and pathophysiology of STS, we conducted untargeted metabolic profiling on pre-operative and post-operative plasma samples from 24 STS patients who underwent surgical tumor removal. Profiling was conducted using ultra-high-performance liquid chromatography-quadrupole time-of-flight/mass spectrometry. Thirty-nine putative metabolites, including phospholipids and acyl-carnitines were identified, indicating changes in lipid metabolism. Phospholipids exhibited an increase in the post-operative samples, while acyl-carnitines showed a decrease. Notably, the levels of pre-operative lysophosphatidylcholine (LPC) O-18:0 and LPC O-16:2 were significantly lower in patients who experienced recurrence after surgery compared to those who did not. Metabolic profiling may identify aggressive tumors that are susceptible to lipid synthase inhibitors. We believe that these findings could contribute to the elucidation of the pathophysiology of STS and the development of further metabolic studies in this rare malignancy. | Lee, Jae-Hwa; Gwon, Mi-Ri; Kim, Jeung-Il; Hwang, Seung-young; Seong, Sook-Jin; Yoon, Young-Ran; Kim, Myungsoo; Kim, Hyojeong | Kyungpook Natl Univ, Sch Med, Dept Mol Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, BK21 FOUR KNU Convergence Educ Program Biomed Sci, Daegu 41944, South Korea; Kyungpook Natl Univ, Clin Om Inst, Sch Med, Daegu 41405, South Korea; Pusan Natl Univ, Sch Med, Dept Orthopaed Surg, Busan 49241, South Korea; Pusan Natl Univ, Biomed Res Inst, Sch Med, Busan 49241, South Korea; Pusan Natl Univ Hosp, Clin Trial Ctr, Pharmacokinet Lab, Busan 49241, South Korea; Kyungpook Natl Univ Hosp, Dept Clin Pharmacol & Therapeut, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Neurosurg, Daegu 41944, South Korea; Maryknoll Hosp, Dept Internal Med, Div Hematooncol, Busan 48972, South Korea | ; Yoon, Young-Ran/GLT-0172-2022 | 58165025100; 56035800800; 8557045700; 58868586400; 57211130049; 14629744500; 57210943611; 57200111630 | leejh0202@knu.ac.kr;miri.gwon@knu.ac.kr;kiimji@pusan.ac.kr;morajara@naver.com;wintersj@knu.ac.kr;yry@knu.ac.kr;aldtn@knu.ac.kr;leonkim80@pusan.ac.kr;leonkim80@naver.com; | METABOLITES | METABOLITES | 2218-1989 | 14 | 5 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY | 2024 | 3.7 | 38.7 | 0 | 2025-05-07 | 0 | 0 | soft tissue sarcoma; metabolomics; lipid; recurrence; surgery | FATTY-ACID SYNTHASE; POTENTIAL BIOMARKERS; CANCER; METABOLISM; ACYLCARNITINES; IDENTIFICATION; TARGETS; CELLS | lipid; metabolomics; recurrence; soft tissue sarcoma; surgery | 13z Docosenamide; 5z 8z Tetradecadienoylcarnitine; acetonitrile; amino acid; bilirubin; cis 4 Decenoylcarnitine; cis 5 Dodecenoylcarnitine; cis 5 Tetradecenoylcarnitine; docosahexaenoic acid; doxorubicin; glutamic acid; glycerophospholipid; ifosfamide; linolenic acid; lysophosphatidylcholine; methanol; n Palmitoyl threonine; Nervonamide; phosphatidylethanolamine; phospholipid; sphingomyelin; unclassified drug; adult; aged; angiosarcoma; Article; chemosensitivity; clinical article; controlled study; diagnostic test accuracy study; excision; female; high performance liquid chromatography; human; human tissue; leiomyosarcoma; lipid blood level; lipid fingerprinting; lipid metabolism; liposarcoma; liquid chromatography-mass spectrometry; male; mass spectrometry; metabolite; metabolomics; middle aged; myxosarcoma; pathophysiology; phenotype; principal component analysis; receiver operating characteristic; sensitivity and specificity; soft tissue sarcoma; ultra performance liquid chromatography | English | 2024 | 2024-05 | 10.3390/metabo14050250 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Complement factor H-related protein 5 alleviates joint inflammation and osteoclast differentiation by disrupting RANK-JNK signaling in collagen antibody-induced arthritis mouse model | Background: Complement Factor H-Related protein 5 (CFHR5) belongs to the factor H/CFHR family and regulates the complement system by modulating factor H's inhibitory activity against C3b. Despite its known role, the impact of CFHR5 on autoimmune arthritis and its relationship to pathophysiological changes in arthritis and bone loss remain unclear. This study aimed to assess the effect of CFHR5 on aggressive osteoclast activity and arthritis using a murine model of collagen antibody-induced arthritis (CAIA). Methods: The effect of recombinant CFHR5 protein (rCFHR5) on arthritis were evaluated in CAIA. The mice were divided into three group and intraperitoneally treated with rCFHR5, methotrexate (MTX) as positive control or PBS as negative control. In the CAIA mouse model, the rCFHR5-treated group significantly reduced the incidence and clinical arthritis equivalent to the MTX group. Clinical arthritis scores, incidence and body weight were measured, and histological analysis of ankle joints was performed by Hematoxylin and Eosin (H&E) and Safranin O - Fast green (SOFG), Tartrate-resistant acid phosphatase (TRAP) staining and Immunohistochemistry. Moreover, to investigate the rCFHR5 role, we isolated murine osteoclast precursor cells (OCPs) from each group, induced osteoclasts with M-CSF and RANKL, and performed TRAP and F-actin staining. To verify the mechanism, mRNA and protein analyses were performed in OCPs. Results: Histological examination of ankle joints revealed substantial reductions in synovial hyperplasia, bone marrow inflammation, bone erosion, cartilage destruction and TRAP-positive cells in the rCFHR5 group compared to the vehicle group. The ankle joints of the rCFHR5 group showed markedly decreased expression of proinflammatory cytokines (TNF-alpha, IL-1 beta and IL-6). Mechanically, treatment with rCFHR5 inhibited RANKLmediated osteoclast differentiation from OCPs and disrupted the RANK-JNK signaling. These findings demonstrate that treatment with rCFHR5 attenuates joint inflammation and reduces osteoclast differentiation, indicating its potential anti-inflammatory effect in autoimmune arthritis models. | Jeon, Chanhyeok; Kim, Dongju; Kim, Kyung-Me; Lee, Seung Hoon; Lee, Ji-Hyun; Kim, Sang-Hyon; Kim, Jong-Seo; Kang, Young Mo; Jo, Sungsin; Kim, Tae-Hwan; Son, Chang-Nam | Hanyang Univ Inst Rheumatol Res HYIRR, Seoul, South Korea; Hanyang Univ, Grad Sch Biomed Sci & Engn, Deparment Translat Med, Seoul, South Korea; Eulji Univ, Uijeongbu Eulji Med Ctr, Sch Med, Dept Rheumatol, Uijongbu, South Korea; Eulji Univ, Eulji Rheumatol Res Inst, Uijongbu, South Korea; Keimyung Univ, Sch Med, Dept Internal Med, Div Rheumatol, Daegu, South Korea; Seoul Natl Univ, Sch Biol Sci, Seoul, South Korea; Preclina Inc, Incheon, South Korea; Kyungpook Natl Univ Hosp, Dept Internal Med, Div Rheumatol, Daegu, South Korea; Soonchunhyang Univ, Dept Biol, Asan, South Korea; Hanyang Univ, Hosp Rheumat Dis, Dept Rheumatol, 222-1 Wangsimni Ro, Seoul 04763, South Korea | Li, Shaofu/O-2241-2019; Jo, Sungsin/AAL-3659-2021; Kim, Jong-Seo/B-6478-2009 | 58168787200; 59376924100; 59376779600; 59843911700; 57217069764; 36470282200; 50961131700; 26221798000; 54399737400; 57171134400; 25951652400 | joejo0517@sch.ac.kr;thkim@hanyang.ac.kr;cnson@eulji.ac.kr; | CYTOKINE | CYTOKINE | 1043-4666 | 1096-0023 | 184 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CELL BIOLOGY;IMMUNOLOGY | 2024 | 3.7 | 38.7 | 0 | 2025-05-07 | 0 | 0 | CFHR5; RANK-JNK signaling; Inflammation; Arthritis; Osteoclasts | C-REACTIVE-PROTEIN; RHEUMATOID-ARTHRITIS; INFLIXIMAB TREATMENT; PATHWAY ACTIVATION; SYSTEM; DESTRUCTION; THERAPY; DISEASE; BINDS; MICE | Arthritis; CFHR5; Inflammation; Osteoclasts; RANK-JNK signaling | Animals; Arthritis, Experimental; Cell Differentiation; collagen antibody-induced arthritis; Disease Models, Animal; Inflammation; Male; MAP Kinase Signaling System; Mice; Osteoclasts; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Recombinant Proteins; Signal Transduction; acid phosphatase tartrate resistant isoenzyme; collagen antibody; colony stimulating factor 1; complement component C3b; complement factor H; complement factor h related protein 5; eosin; F actin; hematoxylin; interleukin 1beta; interleukin 6; malachite green; messenger RNA; methotrexate; osteoclast differentiation factor; receptor activator of nuclear factor kappa B; stress activated protein kinase; tumor necrosis factor; unclassified drug; osteoclast differentiation factor; receptor activator of nuclear factor kappa B; recombinant protein; Tnfrsf11a protein, mouse; animal cell; animal experiment; animal model; animal tissue; ankle joint; Article; body weight; bone erosion; bone marrow; cartilage degeneration; cell function; collagen antibody-induced arthritis; controlled study; immunohistochemistry; in vitro study; incidence; inflammation; JNK signaling; male; mouse; nonhuman; osteoclast; osteoclastogenesis; protein analysis; protein expression; protein function; RNA analysis; staining; stem cell; animal; cell differentiation; collagen antibody-induced arthritis; disease model; drug effect; drug therapy; experimental arthritis; MAPK signaling; metabolism; osteoclast; pathology; signal transduction | English | 2024 | 2024-12 | 10.1016/j.cyto.2024.156790 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Article | Analysis and Diagnosis of the Effect of Voltage and Current Sensor Faults on the State of Charge Estimation of Lithium-ion Batteries Based on Neural Networks | Lithium-ion batteries are currently used as a key energy source in various industrial facilities, electronics, and automotive industries. However, due to the frequent charging and discharging of batteries, overcharging and overdischarging can occur, leading to fire and safety accidents as well as additional financial damages due to equipment failure. Therefore, accurately estimating the battery state of charge (SOC) is very important. In this paper, the robustness of estimation models was analyzed in relation to data collected amidst sensor failures. This analysis was especially pertinent during the battery SOC estimation process, when voltage and current sensors were prone to failure. The impact of these sensor failures on the accuracy and reliability of the SOC estimation models was rigorously scrutinized. Normal data was trained as training data, and Gaussian distribution, Laplace and chi-square combined distribution, Add bias distribution were employed as the test data. Herein, multilayer neural network, long short-term memory, gated recurrent unit, gradient boosting machine (GBM) were used as neural networks, the failure signal processing performance of each estimation algorithm was compared and analyzed, and the failure diagnosis was performed using support vector machine and GBM. | Hwang, Ji-Hwan; Lee, Jong-Hyun; Lee, In Soo | Kyungpook Univ, Dept Elect Engn, 80 Univ Ro, Daegu, South Korea | Lee, jaeho/ABE-6242-2020 | insoolee@knu.ac.kr; | INTERNATIONAL JOURNAL OF CONTROL AUTOMATION AND SYSTEMS | INT J CONTROL AUTOM | 1598-6446 | 2005-4092 | 22 | 5 | SCIE | AUTOMATION & CONTROL SYSTEMS | 2024 | 2.9 | 38.8 | 4 | Add bias distribution; chi-square distribution; Gaussian distribution; GBM; GBM classification; GRU; Laplace distribution; Lithium-ion battery; LSTM; MNN; SOC; SVM classifications | English | 2024 | 2024-05 | 10.1007/s12555-023-0546-9 | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | ○ | Article | Effect of Infection Control Simulation Based on a Negative Pressure Isolation Room Using Mixed Reality | This study aimed to examine the effectiveness of an infection control simulation using mixed reality, comparing simulation fidelity with a high-fidelity mannequin (MN) group and problem-based learning with written cases group. This study used a three-group pretest-posttest quasi-experimental design. Two universities with similar curricula were conveniently selected, and a total of 72 nursing students were recruited. Participants were randomly assigned to three groups of 24 each. In the final analysis, there were 22 participants in the mixed reality groups, 21 in the mannequin groups, and 23 in the problem-based learning with written cases groups. Data were analyzed using descriptive statistics and the chi 2, Kruskal-Wallis, and Wilcoxon signed rank tests. The mixed reality groups had a significantly positive effect on clinical reasoning ability and clinical competence than the problem-based learning with written cases groups, whereas the mannequin groups had a significantly positive effect on clinical competence than the problem-based learning with written cases groups. Mixed reality simulation is an appropriate simulation method that enhances learning immersion, satisfaction, and self-confidence in simulation. Additionally, it can substitute for mannequin simulation in terms of clinical reasoning ability and clinical competence. This study suggests that it is important to the various approaches in simulation fidelity to diversely enhance the competency of nursing students in simulation outcomes. | Kim, Kyeng-Jin; Lee, Joonyoung; Choi, Moon-Ji | Kyungpook Natl Univ, Coll Nursing, Gyongsan, Gyeongbuk, South Korea; Kyungil Univ, Dept Nursing, 50 Gamasilgil, Gyongsan 38428, Gyeongbuk, South Korea | 57226488036; 59252700400; 57201942705 | kkjin@knu.ac.kr;jylee1001@kiu.ac.kr;cmoonj12@kiu.kr; | CIN-COMPUTERS INFORMATICS NURSING | CIN-COMPUT INFORM NU | 1538-2931 | 1538-9774 | 42 | 8 | SCIE;SSCI | COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS;MEDICAL INFORMATICS;NURSING | 2024 | 1.9 | 38.8 | 0 | 2025-05-07 | 0 | 0 | Infection control; Mixed reality; Patient isolators; Simulation fidelity; Virtual reality | CRITICAL THINKING; FRAMEWORK; NURSES; MODULE | Infection control; Mixed reality; Patient isolators; Simulation fidelity; Virtual reality | Adult; Clinical Competence; Education, Nursing, Baccalaureate; Female; Humans; Infection Control; Male; Manikins; Problem-Based Learning; Simulation Training; Students, Nursing; Young Adult; adult; clinical competence; female; human; infection control; male; manikin; nursing education; nursing student; problem based learning; procedures; psychology; simulation training; young adult | English | 2024 | 2024-08 | 10.1097/cin.0000000000001162 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Improved Results on H∞ Performance for Semi-Markovian Jump LPV Systems Under Actuator Saturation and Faults | This paper is concerned with the transformed parameter-dependent H-infinity controller design for semi-Markovian jump linear parameter varying (S-MJLPV) systems under actuator saturation and faults. In the S-MJLPV system, the semi-Markov process transition rate is time-varying during the semi-Markov process and a plant includes time-varying parameters which are bounded and measurable in magnitude. For more practical analysis and synthesis of the S-MJLPV systems, a time-varying actuator fault model and actuator saturation of the controller are considered into account simultaneously. The primary goal of this paper is to develop a transformed parameter-dependent control that makes the closed-loop system stochastically stable with H-infinity performance index gamma and provides less conservative results against actuator saturation and faults. Based on the mode-dependent Lyapunov function, new sufficient conditions are obtained to ensure that the stochastic stability of S-MJLPV systems. Eventually, an example based on the turbofan-engine model is presented to demonstrate the efficacy of our proposed methods. | Saravanakumar, T.; Lee, Sangmoon | Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea | Thangavel, Saravanakumar/JXN-6649-2024; Lee, Sangmoon/C-4502-2018 | 56716219500; 59510733500 | moony@knu.ac.kr; | INTERNATIONAL JOURNAL OF CONTROL AUTOMATION AND SYSTEMS | INT J CONTROL AUTOM | 1598-6446 | 2005-4092 | 22 | 6 | SCIE | AUTOMATION & CONTROL SYSTEMS | 2024 | 2.9 | 38.8 | 1.01 | 2025-05-07 | 3 | 3 | Actuator faults; actuator saturation; linear parameter varying systems; semi-Markovian jump systems; transformed parameter dependent control | STABILITY ANALYSIS; STABILIZATION; PARAMETERS | Actuator faults; actuator saturation; linear parameter varying systems; semi-Markovian jump systems; transformed parameter dependent control | Actuators; Closed loop systems; Linear systems; Lyapunov functions; Markov processes; Stochastic systems; Time varying control systems; Turbofan engines; Actuator fault; Actuator saturations; H ∞ performance; Linear parameter varying systems; Markovian jump linear; Markovian jump systems; Parameter-dependent control; Semi markov process; Semi-markovian jump system; Transformed parameter dependent control; Controllers | English | 2024 | 2024-06 | 10.1007/s12555-023-0475-7 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Path-tracking Robust Model Predictive Control of an Autonomous Steering System Using LMI Optimization With Independent Constraints Enforcement | Autonomous vehicles face their toughest challenge when navigating harsh road conditions due to continuous changes in cornering coefficients and vehicle velocity. To address this issue, this paper proposes a method for robust control of an autonomous steering system, incorporating independent constraint enforcement to enhance safe driving. Firstly, parameter uncertainties, including the front and rear cornering stiffness of the tires and the variations in vehicle velocity, are modeled as a polytope. This modeling approach enables the consideration of worst-case scenarios for uncertain parameters. Secondly, a robust model predictive control is designed based on the Lyapunov stability theorem, ensuring stability across all possible polytope vertices. Following that, independent constraint enforcement is implemented, including state and input control variables, to guarantee driving safety. Finally, various scenario simulations are conducted to validate the effectiveness of the proposed method. | Nam, Nguyen Ngoc; Han, Kyoungseok | Kyungpook Natl Univ, Sch Mech Engn, Daegu 41566, South Korea; Phenikaa Univ, Fac Elect & Elect Engn, Hanoi 12116, Vietnam; Hanyang Univ, Dept Automot Engn, Seoul 04763, South Korea | Nam, Nguyen/AAM-6955-2021 | 57194459340; 56465294700 | nam.nguyenngoc@phenikaa-uni.edu.vn;kyoungsh@hanyang.ac.kr; | INTERNATIONAL JOURNAL OF CONTROL AUTOMATION AND SYSTEMS | INT J CONTROL AUTOM | 1598-6446 | 2005-4092 | 22 | 11 | SCIE | AUTOMATION & CONTROL SYSTEMS | 2024 | 2.9 | 38.8 | 0.34 | 2025-05-07 | 1 | 1 | Autonomous steering system; constraints; linear matrix inequality; robust model predictive control | VEHICLES | Autonomous steering system; constraints; linear matrix inequality; robust model predictive control | Autonomous vehicles; Constraint theory; Invariance; Linear matrix inequalities; Magnetic levitation vehicles; Robust control; Robustness (control systems); Steering; Velocity control; Autonomous steering; Autonomous steering system; Constraint; Constraints enforcement; Linear matrix in equalities; Path tracking; Polytopes; Robust model predictive control; Steering systems; Vehicle velocity; Predictive control systems | English | 2024 | 2024-11 | 10.1007/s12555-023-0772-1 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Article | Non-fragile tracking controller design for fractional order systems against active disturbance rejection | In this work, a new non-fragile based tracking controller design for fractional order systems with non-linear uncertainty, unidentified external disturbances, and time-delay is investigated. A novel structure of a fractional order non-fragile repetitive controller is suggested to obtain the tracking performance for the addressed system. In particular, gain fluctuations are used with an improved two-degrees-of-freedom Smith predictor in the construction of this structure. Using the Lyapunov–Krasovskii stability theory and a continuous amplitude distributed equivalent system, a new set of criteria to determine the asymptotic stability of the associated closed-loop system is proposed in the context of linear matrix inequalities. Within a single framework, disturbance estimation, asymptotic tracking, and time delay compensation are all done using the obtained stability results. The resulting theoretical results are finally confirmed by numerical examples that demonstrate how the specified constraints could lead the system output to precisely match any defined reference signal by balancing for the unidentified exterior disturbance. © The Author(s), under exclusive licence to EDP Sciences, Springer-Verlag GmbH Germany, part of Springer Nature 2024. | Arivumani, S.; Vadivel, P.; Rajchakit, G.; Saravanakumar, T. | Department of Mathematics, Hindusthan Institute of Technology, Coimbatore, 641032, India; Department of Mathematics, Kongu Engineering College, Erode, 638060, India; Department of Mathematics, Maejo University, Chiang Mai, 50290, Thailand; School of Electronic and Electrical Engineering, Kyungpook National University, Daegu, 41566, South Korea | 59213109400; 54386326000; 57201986186; 56716219500 | arivusrkv@gmail.com; | European Physical Journal: Special Topics | EUR PHYS J-SPEC TOP | 1951-6355 | 1951-6401 | SCIE | PHYSICS, MULTIDISCIPLINARY | 2024 | 2.3 | 39.0 | 0.36 | 2025-05-07 | 1 | English | Article in press | 2024 | 10.1140/epjs/s11734-024-01217-z | 바로가기 | 바로가기 | 바로가기 | |||||||||||
| ○ | ○ | Article | Ethanol Extract of Ampelopsis brevipedunculata Rhizomes Suppresses IgE-Mediated Mast Cell Activation and Anaphylaxis | More than 20% of the world's population suffers from allergic diseases, including allergic asthma, rhinitis, and atopic dermatitis that severely reduce the patient's quality of life. The treatment of allergy has been developed, but there are still unmet needs. Ampelopsis brevipedunculata (Maxim.) Trautv. is a traditional medicinal herb with beneficial bioactivities, such as antioxidant, anti-hypertension, anti-viral, anti-mutagenic, and skin and liver (anti-hepatotoxic) protective actions. However, its anti-allergic effect has not been addressed. This study designed to investigate the pharmacological effect of an ethanol extract of A. brevipedunculata rhizomes (ABE) on mast cell and anaphylaxis models. For in vivo studies, we used ovalbumin-induced active systemic anaphylaxis (ASA) and immunoglobulin (Ig) E-mediated passive cutaneous anaphylaxis (PCA) models. In ASA model, oral administration of ABE (1, 10, and 100 mg/kg) attenuated the anaphylactic responses, such as hypothermia, serum histamine, and IgE productions. In PCA model, ABE also suppressed the plasma extravasation and swelling. The underlying mechanisms of action were identified in various mast cell types. In vitro, ABE (10, 30, and 60 mu g/mL) inhibited the release of essential allergic mediators, such as histamine and beta-hexosaminidase, in a concentration-dependent manner. ABE prevented the rapid increase in intracellular calcium levels induced by the DNP-HSA challenge. In addition, ABE downregulated the tumor necrosis factor-alpha and interleukin-4 by suppressing the activation of nuclear factor-kappa B. Collectively, this study is the first to identify the anti-allergic effect of ABE, suggesting that ABE is a promising candidate for treating allergic diseases. | Park, Ji-Yeong; Kim, Min-Jong; Choi, Young-Ae; Lee, Seung Woong; Lee, Soyoung; Jang, Yong Hyun; Kim, Sang-Hyun | Kyungpook Natl Univ, Sch Med, Dept Pharmacol, CMRI, Daegu 700422, South Korea; Korea Res Inst Biosci & Biotechnol, Funct Biomat Res Ctr, Jeongeup 56212, South Korea; Kyungpook Natl Univ, Sch Med, Dept Dermatol, Daegu 41944, South Korea | 58992148900; 57192888932; 7404777420; 55033843800; 8537269200; 57016046400; 57210450420 | rbf40@naver.com;wowdamien@nate.com;korryy@daum.net;lswdoc@kribb.re.kr;sylee@kribb.re.kr;yhjang@knu.ac.kr;shkim72@knu.ac.kr; | ADVANCES IN PHARMACOLOGICAL AND PHARMACEUTICAL SCIENCES | ADV PHARM PHARM SCI | 2633-4682 | 2633-4690 | 2024 | ESCI | PHARMACOLOGY & PHARMACY | 2024 | 3 | 39.1 | 0 | 2025-04-16 | 0 | 0 | IN-VITRO; HISTAMINE; ANTIBODY; RELEASE; LESSONS; IL-4 | alcohol; ampelopsis brevipedunculata extract; antiallergic agent; beta n acetylhexosaminidase; histamine; immunoglobulin E; immunoglobulin enhancer binding protein; interleukin 4; plant extract; tumor necrosis factor; unclassified drug; Ampelopsis; Ampelopsis brevipedunculata; anaphylaxis; animal cell; animal experiment; animal model; animal tissue; Article; calcium cell level; cell activation; controlled study; cytokine release; cytotoxicity; degranulation; down regulation; extravasation; gene expression; histamine blood level; hypothermia; immediate type hypersensitivity; immunoglobulin production; in vitro study; in vivo study; male; mast cell; mast cell degranulation; mouse; nonhuman; passive skin anaphylaxis; rat; rhizome; swelling; systemic anaphylaxis | English | 2024 | 2024-04-04 | 10.1155/2024/5083956 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Population pharmacokinetic modeling of sufentanil in adult Korean patients undergoing cardiopulmonary bypass surgery | Sufentanil is frequently used as an anesthetic agent in cardiac surgery owing to its cardiovascular safety and favorable pharmacokinetics. However, the pharmacokinetics profiles of sufentanil in patients undergoing cardiopulmonary bypass (CPB) surgery remain less understood, which is crucial for achieving the desired level of anesthesia and mitigating surgical complications. Therefore, this study aimed to develop a population pharmacokinetic model of sufentanil in patients undergoing CPB surgery and elucidate the clinical factors affecting its pharmacokinetic profile. Adult patients who underwent cardiac surgery with CPB and were administered sufentanil for anesthesia were enrolled. Arterial blood samples were collected to quantify plasma concentrations of sufentanil and clinical laboratory parameters, including inflammatory cytokines. A population pharmacokinetic model was established using nonlinear mixed-effects modeling. Simulations were performed using the pharmacokinetic parameters of the final model. Overall, 20 patients were included in the final analysis. Sufentanil pharmacokinetics were modeled using a two-compartment model, accounting for CPB effects. Sufentanil clearance increased 2.80-fold during CPB and warming phases, while the central compartment volume increased 2.74-fold during CPB. CPB was a significant covariate affecting drug clearance and distribution volume. No other significant covariates were identified despite increased levels of the inflammatory cytokines, including IL-6, IL-8, and TNF-alpha during CPB. The simulation indicated a 30 mu g loading dose and 40 mu g/h maintenance infusion for target-controlled infusion. Additionally, a bolus dose of 60 mu g was added at CPB initiation to adjust for exposure changes during this phase. Considering the target sufentanil concentrations, a uniform dosing regimen was acceptable for effective analgesia. This study developed a population pharmacokinetic model of sufentanil in patients undergoing CPB, revealing that CPB significantly affects drug clearance and distribution, leading to recommendations for adjusted dosing regimens during surgery.image | Khaowroongrueng, Vipada; Son, Kuk Hui; Lee, Sang-Min; Lee, JiYeon; Park, Chun-Gon; Lee, Seok In; Shin, Dongseong; Shin, Kwang-Hee | Govt Pharmaceut Org, Res & Dev Inst, Bangkok, Thailand; Gachon Univ, Coll Med, Gil Med Ctr, Dept Thorac & Cardiovasc Surg, Incheon, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, Daegu 41566, South Korea; Gachon Univ, Coll Med, Gil Med Ctr, Dept Anesthesiol & Pain Med, Incheon, South Korea; Gachon Univ, Coll Med, Gil Med Ctr, Dept Clin Pharmacol & Therapeut, Incheon 21565, South Korea | ; Lee, Sang-Jun/A-3892-2015 | 57191581545; 56494240600; 57213176293; 57185921600; 57212259408; 57193205579; 55384018800; 35216279300 | dsshin@gilhospital.com;kshin@knu.ac.kr; | CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY | CPT-PHARMACOMET SYST | 2163-8306 | 13 | 10 | SCIE | PHARMACOLOGY & PHARMACY | 2024 | 3 | 39.1 | 0.67 | 2025-05-07 | 2 | 2 | TARGET-CONTROLLED INFUSION; CARDIAC-SURGERY | Adult; Aged; Anesthetics, Intravenous; Cardiopulmonary Bypass; Cytokines; Female; Humans; Male; Middle Aged; Models, Biological; Republic of Korea; Sufentanil; albumin; bicarbonate; creatinine; cyclic AMP responsive element binding protein binding protein; cytochrome P450 3A4; cytokine; gamma interferon; heparin; interleukin 1beta; interleukin 6; interleukin 8; midazolam; propofol; protein; rocuronium; sufentanil; tumor necrosis factor; cytokine; intravenous anesthetic agent; sufentanil; abnormal blood pressure; adult; aged; analgesia; anesthesia; anesthesiologist; arterial blood; Article; bispectral index; blood pressure; blood sampling; body height; body mass; body weight; bolus injection; cardiopulmonary bypass; clinical article; compartment volume; continuous infusion; coronary artery bypass graft; density; drug clearance; erythrocyte count; female; genetic polymorphism; genotype; hematocrit; human; hypothermia; intercompartmental clearance; interindividual variability; Korean (people); limit of quantitation; liquid chromatography-mass spectrometry; loading drug dose; male; parameters; pH; pharmacokinetic parameters; polymerase chain reaction; postoperative complication; prospective study; rectal temperature; relative standard error; reliability; renal replacement therapy; residual variability; simulation; structural model; validation study; valvuloplasty; volume of distribution; warming; biological model; blood; middle aged; South Korea | English | 2024 | 2024-10 | 10.1002/psp4.13205 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Geostationary Environment Monitoring Spectrometer (GEMS) polarization characteristics and correction algorithm | The Geostationary Environment Monitoring Spectrometer (GEMS) is the first geostationary earth orbit (GEO) environmental instrument, onboard the Geostationary Korea Multi-Purpose Satellite-2B (GEO-KOMPSAT-2B) launched on 19 February 2020, and is measuring reflected radiance from the earth's surface and atmosphere system in the range of 300-500 nm in the ultraviolet-visible (UV-Vis) region. The radiometric response of a satellite sensor that measures the UV-Vis wavelength region can depend on the polarization states of the incoming light. To reduce the sensitivity due to polarization, many current low earth orbit (LEO) satellites are equipped with a scrambler to depolarize the signals or a polarization measurement device (PMD) that simultaneously measures the polarization state of the atmosphere, then utilizes it for a polarization correction. However, a novel polarization correction algorithm is required since GEMS does not have a scrambler or a PMD. Therefore, this study aims to improve the radiometric accuracy of GEMS by developing a polarization correction algorithm optimized for GEMS that simultaneously considers the atmosphere's polarization state and the instrument's polarization sensitivity characteristics. The polarization factor and axis were derived by the preflight test on the ground as a function of wavelengths, showing a polarization sensitivity of more than 2 % at some specific wavelengths. The polarization states of the atmosphere are configured as a look-up table (LUT) using the Vector Linearized Discrete Ordinate Radiative-Transfer model (VLIDORT). Depending on the observation geometry and atmospheric conditions, the observed radiance spectrum can include a polarization error of 2 %. The performance of the proposed GEMS polarization algorithm was assessed using synthetic data, and the errors due to polarization were found to be larger in clear regions than in cloudy regions. After the polarization correction, polarization errors were reduced close to zero for almost all wavelengths, including the wavelength regions with high peaks and curvatures in the GEMS polarization factor, which sufficiently demonstrates the effectiveness of the proposed polarization correction algorithm. From the actual observation data after the launch of GEMS, the diurnal variation for the spatial distribution of polarization error was confirmed to be minimum at noon and maximum at sunrise/sunset. This can be used to improve the quality of GEMS measurements, the first geostationary environmental satellite, and then contribute to the retrieved accuracy of various Level-2 products, such as trace gases and aerosols in the atmosphere. | Choi, Haklim; Liu, Xiong; Jeong, Ukkyo; Chong, Heesung; Kim, Jhoon; Ahn, Myung Hwan; Ko, Dai Ho; Lee, Dong-Won; Moon, Kyung-Jung; Lee, Kwang-Mog | Kyungpook Natl Univ, Dept Astron & Atmospher Sci, Daegu, South Korea; Harvard & Smithsonian, Ctr Astrophys, Cambridge, MA USA; Pukyong Natl Univ, Div Earth Environm Syst Sci, Major Spatial Informat Engn, Busan, South Korea; Yonsei Univ, Dept Atmospher Sci, Seoul, South Korea; Ewha Womans Univ, Dept Climate & Energy Syst Engn, Seoul, South Korea; Korea Aerosp Res Inst, Satellite Payload Dev Div, Daejeon, South Korea; Natl Inst Environm Res, Environm Satellite Ctr, Incheon, South Korea; Kyungpook Natl Univ, Kyungpook Inst Oceanog, Daegu, South Korea; Harvard & Smithsonian, Ctr Astrophys, Cambridge, MA USA | Ahn, M.H./AAX-3455-2020; Kim, Jhoon/F-6635-2013; Chong, Heesung/AAB-4010-2022; Liu, Xiong/P-7186-2014; LIu, Xiong/P-7186-2014 | 57215186877; 57200790631; 53363791600; 57204434009; 9233714800; 58861449300; 13405090400; 57202974918; 36015318800; 35412373800 | ukkyo.jeong@pknu.ac.kr;kmlee@knu.ac.kr; | ATMOSPHERIC MEASUREMENT TECHNIQUES | ATMOS MEAS TECH | 1867-1381 | 1867-8548 | 17 | 1 | SCIE | METEOROLOGY & ATMOSPHERIC SCIENCES | 2024 | 3.3 | 39.2 | 2.48 | 2025-05-07 | 5 | 6 | RADIATIVE-TRANSFER CODE; ATMOSPHERIC CORRECTION; AEROSOL PROPERTIES; VECTOR VERSION; SATELLITE DATA; INSTRUMENT; MISSION; GOME-2; CALIBRATION; VALIDATION | accuracy assessment; algorithm; geostationary satellite; polarization; satellite sensor; spectrometer | English | 2024 | 2024-01-11 | 10.5194/amt-17-145-2024 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Posttraumatic Growth Experiences of North Korean Adolescent Refugees Living in South Korea: A Qualitative Case Study | Objective: This study aimed to explore the posttraumatic growth (PTG) experiences of North Korean adolescent refugees. The qualitative context of PTG experiences and influencing factors was explored based on the experiences vividly described by North Korean adolescent refugees. Method: I recruited participants for a qualitative case study, targeting "high-growth type" and "low-growth type" adolescents classified through latent profile analysis. A 1:1 in-depth interview was conducted with five high-growth and four low-growth adolescents who agreed to participate in the study. Results: Their PTG appeared to coexist with posttraumatic stress disorder symptoms such as anxiety and depression. In addition, the PTG of North Korean refugee adolescents was particularly remarkable in the areas of "personal strength" and "relating to others." The influencing factors of PTG were described in the qualitative contexts of "constructive rumination process," "self-disclosure," "peer network from both South and North Korea," and "role of significant others." Conclusions: This study confirmed that North Korean adolescent refugees actively strive for growth after trauma. In order to lead their PTG better, specific interventions are required for intentional rumination process, human support resources, and self-opening that affect PTG. This study has academic value in that it compares and verifies the factors affecting PTG by interviewing high- and low-growth adolescents. Clinical Impact Statement This study promotes a broader understanding of the posttraumatic experiences of trauma survivors, including North Korean adolescent refugees, and provides effective intervention strategies and plans in clinical settings. | Yang, Hyerin | Kyungpook Natl Univ, Ctr Social Welf Res, 80 Deahak ro, Daegu 41566, South Korea | 57194507209 | rinyang0103@gmail.com; | PSYCHOLOGICAL TRAUMA-THEORY RESEARCH PRACTICE AND POLICY | PSYCHOL TRAUMA-US | 1942-9681 | 1942-969X | 16 | SSCI | PSYCHOLOGY, CLINICAL;PSYCHIATRY | 2024 | 2.3 | 39.2 | 0 | 2025-05-07 | 0 | 0 | North Korean adolescent refugees; posttraumatic growth; qualitative case study | TRAUMA; RESILIENCE; DISORDER | North Korean adolescent refugees; posttraumatic growth; qualitative case study | Adolescent; Democratic People's Republic of Korea; Female; Humans; Male; Posttraumatic Growth, Psychological; Qualitative Research; Refugees; Republic of Korea; Stress Disorders, Post-Traumatic; adolescent; ethnology; female; human; male; North Korea; posttraumatic growth (psychology); posttraumatic stress disorder; psychology; qualitative research; refugee; South Korea | English | 2024 | 2024-12 | 10.1037/tra0001668 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Article | Prevalence of Lifetime Psychiatric Disorders and Suicidality in Adults With Subthreshold Posttraumatic Stress Disorder: A Population-Based Nationwide Study in Korea | Background: Subthreshold posttraumatic stress disorder (PTSD) is a chronic condition, and despite its clinical importance, few studies have been conducted. We investigated the relationship of subthreshold PTSD with various psychiatric disorders and suicidality in a South Korean general population. Method: A total of 5,102 respondents, aged at least 18 years, completed face-to-face interviews using the Korean version of the Composite International Diagnostic Interview and questionnaires for lifetime suicidal ideation, plans, and attempts. Subthreshold PTSD was defined as at least one symptom in each of the three symptom clusters (Criteria B, C, and D) and a symptom duration of >= 1 month (Criterion E). Results: The lifetime prevalence of subthreshold PTSD (2.5%) was higher than that of PTSD (1.5%). After adjusting for sociodemographic factors, subthreshold PTSD was significantly associated with nicotine use disorders, major depressive disorder, obsessive-compulsive disorder (OCD), generalized anxiety disorder, and specific phobia. Among psychiatric disorders, the odds ratio for OCD was notably high. Subthreshold PTSD was associated with increased suicidal ideation (adjusted OR [AOR] = 2.90, 95% CI [1.98, 4.26]), suicidal plans (AOR = 3.58, [1.86, 6.89]), and suicide attempts (AOR = 3.93, [1.93, 8.01]) after adjusting for sociodemographic factors. When adjusted for sociodemographic factors and psychiatric disorders, suicidal ideation (AOR = 2.04, [1.34, 3.11]) remained statistically significant. Conclusion: This study found that subthreshold PTSD was associated with various psychiatric disorders and suicidality. Increased attention to the mental health of individuals with subthreshold PTSD is necessary. Clinical Impact Statement The prevalence of subthreshold posttraumatic stress disorder (PTSD) is higher than that of PTSD, and subthreshold PTSD is associated with various psychiatric disorders and suicidality. However, subthreshold PTSD can be overlooked in clinical settings because it is studied less often and individuals with subthreshold PTSD are less likely to be aware of the symptoms. Therefore, considering the high suicidal risk of individuals with subthreshold PTSD in this study, we suggest that clinicians and policy makers should pay attention to the mental health of individuals with subthreshold PTSD. | Kim, Hyerim; Lee, Jimin; Chang, Sung Man; Hong, Jin Pyo; Lee, Dong-Woo; Hahm, Bong-Jin; Cho, Seong-Jin; Park, Jong-Ik; Jeon, Hong Jin; Seong, Su Jeong; Park, Jee Eun; Kim, Byung-Soo | Kyungpook Natl Univ Hosp, Dept Psychiat, Daegu, South Korea; Kyungpook Natl Univ Hosp, Sch Med, Dept Psychiat, Daegu, South Korea; Sungkyunkwan Univ, Sch Med, Dept Psychiat, Seoul, South Korea; Inje Univ, Coll Med, Dept Psychiat, Busan, South Korea; Seoul Natl Univ, Coll Med, Dept Psychiat, Seoul, South Korea; Gachon Med Sch, Dept Psychiat, Incheon, South Korea; Kangwon Natl Univ, Sch Med, Dept Psychiat, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kangdong Sacred Heart Hosp, Dept Psychiat, Seoul, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Psychiat, Daegu, South Korea | ; Kim, Byung-Soo/H-4047-2013; Lee, Dong/H-2427-2012; Hahm, Bong-Jin/J-5714-2012 | because99@hanmail.net; | PSYCHOLOGICAL TRAUMA-THEORY RESEARCH PRACTICE AND POLICY | PSYCHOL TRAUMA-US | 1942-9681 | 1942-969X | 16 | 1 | SSCI | PSYCHOLOGY, CLINICAL;PSYCHIATRY | 2024 | 2.3 | 39.2 | 2 | PTSD; subthreshold; mental disorders; suicide; Korea | OBSESSIVE-COMPULSIVE DISORDER; MENTAL-HEALTH; PARTIAL PTSD; FULL PTSD; COMORBIDITY; COMMUNITY; TRAUMA; IDEATION; ALCOHOL; ATTACKS | English | 2024 | 2024-01 | 10.1037/tra0001185 | 바로가기 | 바로가기 | 바로가기 | |||||||||
| ○ | ○ | Article | Adverse Effects of Avobenzone on Boar Sperm Function: Disruption of Protein Kinase A Activity and Tyrosine Phosphorylation | Avobenzone (AVO), an ultraviolet (UV) filter, is frequently used as an ingredient in personal cosmetics. This UV filter has been found to be easily exposed in swimming pools and beaches, and it has been detected in human urine and blood. Moreover, numerous studies have demonstrated that AVO exhibits endocrine -disrupting properties. Nevertheless, the effects of AVO on male fertility have not yet fully understood. Therefore, this study aimed to assess the effects of AVO on various sperm functions during capacitation. First, boar spermatozoa were treated with various AVO concentrations. After treatment, sperm motility and kinetic characteristics, capacitation status, intracellular adenosine triphosphate (ATP) levels, and sperm viability were evaluated. Moreover, Western blot analysis w.as conducted to evaluate protein kinase A (PKA) activity and tyrosine phosphorylation. As a result, AVO treatment significantly decreased total motility, progressive motility, and several kinetic characteristics at high concentrations (50 and 100 mu M). Furthermore, the capacitation status dosedependently decreased. Conversely, no significant differences in acrosome reaction, cell viability, and intracellular ATP levels were observed. However, the intracellular ATP level tended to decrease. In addition, AVO dosedependently induced abnormal changes in PKA activity and tyrosine phosphorylation. Although AVO did not directly exert a toxic effect on cell viability, it ultimately negatively affected sperm functions through abnormal alterations in PKA activity and tyrosine phosphorylation. Thus, the potential implications on male fertility must be considered when contemplating the safe utilization of AVO. | Lee, Woo-Jin; Hwang, Ju-Mi; Jo, Jae-Hwan; Jang, Seung-Ik; Jung, Eun-Ju; Bae, Jeong-Won; Ha, Jae Jung; Kim, Dae-Hyun; Kwon, Woo -Sung | Kyungpook Natl Univ, Dept Anim Sci & Biotechnol, Sangju 37224, Gyeongsangbug D, South Korea; Kyungpook Natl Univ, Dept Anim Biotechnol, Sangju 37224, Gyeongsangbuk D, South Korea; Gyeongbuk Livestock Res Inst, Yeongju 36052, Gyeongsangbug D, South Korea; Chonnam Natl Univ, Dept Anim Sci, Gwangju 61186, South Korea; Kyungpook Natl Univ, Res Inst Innovat Anim Sci, Sangju 37224, Gyeongsangbug D, South Korea | Bae, Jeong-Won/AAH-4932-2021; Kwon, Woo-Sung/J-6731-2019 | 57377138800; 57217871526; 58346379700; 58346379800; 57377289200; 57211231093; 55848402300; 57211228843; 54383715800 | chunja2411@naver.com;wskwon@knu.ac.kr; | REPRODUCTIVE TOXICOLOGY | REPROD TOXICOL | 0890-6238 | 1873-1708 | 125 | SCIE | REPRODUCTIVE BIOLOGY;TOXICOLOGY | 2024 | 2.8 | 39.3 | 0.51 | 2025-05-07 | 1 | 1 | Avobenzone; Capacitation; Sperm functions; Male reproductive toxicity | CHEMICAL UV FILTERS; HYPERACTIVATED MOTILITY; DEVELOPMENTAL TOXICITY; REPRODUCTIVE TOXICITY; ENDOCRINE ACTIVITY; EXPOSURE; CAPACITATION; PROGESTERONE; SPERMATOZOA | Avobenzone; Capacitation; Male reproductive toxicity; Sperm functions | Adenosine Triphosphate; Animals; Cyclic AMP-Dependent Protein Kinases; Humans; Male; Phosphorylation; Propiophenones; Semen; Sperm Capacitation; Sperm Motility; Spermatozoa; Swine; Tyrosine; adenosine triphosphate; avobenzone; cyclic AMP dependent protein kinase; tyrosine; adenosine triphosphate; avobenzone; cyclic AMP dependent protein kinase; propiophenone derivative; tyrosine; acrosome reaction; adverse event; animal experiment; animal model; Article; cell viability; controlled study; enzyme activity; kinetics; male; male fertility; nonhuman; pig; practice guideline; protein phosphorylation; reproductive toxicity; sperm capacitation; sperm function; sperm viability; spermatozoon; spermatozoon motility; Western blotting; animal; human; metabolism; phosphorylation; sperm; spermatozoon motility | English | 2024 | 2024-04 | 10.1016/j.reprotox.2024.108559 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Effect of 4-nonylphenol (4-NP) on sperm function: Insights into the PI3K/ PDK1/AKT signaling pathway during capacitation | 4-Nonylphenol (4-NP) is an endocrine-disrupting chemical that impairs animal and human reproduction. However, the mechanisms underlying male reproductive dysfunction by 4-NP have not been fully understood. Herein, we demonstrated the effects of 4-NP on boar sperm functions and molecular mechanisms. Spermatozoa were treated with various concentrations of 4-NP (0, 10, 25, 50, 75, and 100 mu M) during capacitation. Then, we evaluated sperm motility, capacitation status, intracellular ATP level, and cell viability. Finally, we measured the expression of phosphorylated protein kinase A (PKA), tyrosine phosphorylation, and proteins related to the phosphatidylinositol 3 kinase (PI3K)/phosphoinositide-dependent kinase-1 (PDK1)/protein kinase B (AKT) signaling pathways following exposure to 4-NP. Sperm motility and motion kinematics were reduced by 4-NP, whereas intracellular ATP levels were increased significantly in a dose-dependent manner. Furthermore, the expression levels of p-PI3K, PTEN, p-PDK1, AKT, and p -AKT exhibited a significant dose-dependent increase. Moreover, abnormal activation of PKA and tyrosine phosphorylation were observed. Specifically, the -24 kDa pPKA substrate demonstrated a significant reduction following exposure to 4-Np. In addition, the -18 kDa p-PKA substrate and tyrosine-phosphorylated proteins displayed a significant dose-dependent increase after exposure to 4-NP. Our results suggest that 4-NP may induce detrimental effects on sperm functions through abnormal changes in PKA activity and tyrosine phosphorylation during capacitation, possibly through unusual alteration of the PI3K/PDK1/AKT signaling pathway. Therefore, 4-NP must be cautiously used considering its reproductive toxicity. | Hwang, Ju-Mi; Bae, Jeong-Won; Lee, Woo-Jin; Kwon, Woo-Sung | Kyungpook Natl Univ, Dept Anim Sci & Biotechnol, Sangju 37224, Gyeongsangbug D, South Korea; Kyungpook Natl Univ, Dept Anim Biotechnol, Sangju 37224, Gyeongsangbug D, South Korea; Kyungpook Natl Univ, Res Inst Innovat Anim Sci, Sangju 37224, Gyeongsangbug D, South Korea | Bae, Jeong-Won/AAH-4932-2021; Kwon, Woo-Sung/J-6731-2019 | 57217871526; 57211231093; 57377138800; 54383715800 | wskwon@knu.ac.kr; | REPRODUCTIVE TOXICOLOGY | REPROD TOXICOL | 0890-6238 | 1873-1708 | 124 | SCIE | REPRODUCTIVE BIOLOGY;TOXICOLOGY | 2024 | 2.8 | 39.3 | 2.05 | 2025-05-07 | 4 | 4 | 4-Nonylphenol; Spermatozoa; Sperm functions; PI3K/PDK1/AKT signaling pathway; Reproductive toxicity | INDUCED APOPTOSIS; MALE RATS; NONYLPHENOL; MOTILITY; SPERMATOZOA; ACTIVATION; INHIBITION; INTEGRITY; EXPOSURE; KINASE | 4-Nonylphenol; PI3K/PDK1/AKT signaling pathway; Reproductive toxicity; Sperm functions; Spermatozoa | Adenosine Triphosphate; Animals; Cyclic AMP-Dependent Protein Kinases; Humans; Male; Phenols; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Semen; Signal Transduction; Sperm Capacitation; Sperm Motility; Spermatozoa; Swine; Tyrosine; 4 nonylphenol; adenosine triphosphate; cyclic AMP dependent protein kinase; phosphatidylinositol 3 kinase; phosphoinositide dependent protein kinase 1; protein kinase B; tyrosine; 4-nonylphenol; adenosine triphosphate; cyclic AMP dependent protein kinase; phenol derivative; phosphatidylinositol 3 kinase; protein kinase B; tyrosine; animal cell; Article; cell level; cell viability; concentration response; Duroc pig; enzyme activation; enzyme substrate; nonhuman; PI3K PDK1 AKT signaling; Pi3K/Akt signaling; protein expression; protein phosphorylation; reproductive toxicity; sperm capacitation; sperm function; spermatozoon motility; animal; human; male; metabolism; phosphorylation; pig; signal transduction; sperm; sperm capacitation; spermatozoon | English | 2024 | 2024-03 | 10.1016/j.reprotox.2024.108545 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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