연구성과로 돌아가기
2020 연구성과 (180 / 270)
※ 컨트롤 + 클릭으로 열별 다중 정렬 가능합니다.
Excel 다운로드
| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ○ | ○ | Article | Effects of Time on Phenolics and in vitro Bioactivity in Autoclave Extraction of Graviola (Annona muricata) Leaf | We investigated the effects of different autoclave extraction times (1-6 h) on the antioxidant, antidiabetic, and anti-inflammatory activities of phenolic compounds isolated from graviola (Annona muricata) leaves. In terms of yield and content of total polyphenols, total flavonoids, rutin, and kaempferol-3-O-rutinoside, the optimal extraction time was 4 h. At this time point, water extracts from graviola leaves (WEG) exhibited the highest DPPH radical scavenging activity, ferric reducing antioxidant power, and alpha-glucosidase inhibitory activity. The alpha-glucosidase inhibitory activity of WEG was significantly stronger than that of acarbose. Furthermore, WEG significantly suppressed lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells and inhibited UVB-induced activator protein-1 (AP-1)-dependent transcription in human keratinocytes. In conclusion, WEG can be used as functional food ingredients in the food industry. | Choi, Moonkyeung; Kang, Yu-Ra; Zu, Hyo Don; Lim, In-Sook; Jung, Sung Keun; Chang, Yoon Hyuk | Kyung Hee Univ, Dept Food & Nutr, Seoul 02447, South Korea; Kyung Hee Univ, Bionanocomposite Res Ctr, Seoul 02447, South Korea; Korea Univ, Dept Food Biosci & Technol, Seoul 02841, South Korea; Chamhan Food Inc, Yeoncheon 11018, Gyeonggi Do, South Korea; Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41556, South Korea | Jung, SUNG KEUN/AGR-2623-2022; Chang, Yoon/AAH-6583-2019; Kang, Yu-Ra/IUM-6207-2023 | 57191894682; 57197792821; 57215487235; 57202900205; 35310491400; 36092517300 | skjung04@knu.ac.kr;yhchang@khu.ac.kr; | BIOTECHNOLOGY AND BIOPROCESS ENGINEERING | BIOTECHNOL BIOPROC E | 1226-8372 | 1976-3816 | 25 | 1 | SCIE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | 2020 | 2.836 | 58.8 | 0.73 | 2025-06-25 | 13 | 13 | bioactive compounds; flavonoids; food ingredients; natural antioxidants; phenolics | ANTIOXIDANT ACTIVITY; PLANT-EXTRACTS; LEAVES; INHIBITION; L.; INFLAMMATION; STABILITY | bioactive compounds; flavonoids; food ingredients; natural antioxidants; phenolics | Antioxidants; Extraction; Food additives; Nitric oxide; Pressure vessels; alpha glucosidase; Annona muricata extract; flavonoid; nicotiflorin; nitric oxide; phenol derivative; polyphenol derivative; rutoside; transcription factor AP 1; Anti-inflammatory activity; Bioactive compounds; DPPH radical scavenging activities; Ferric reducing antioxidant power; Food ingredients; In-vitro bioactivity; Natural antioxidants; Phenolics; animal cell; antidiabetic activity; antiinflammatory activity; antioxidant activity; Article; controlled study; drug isolation; enzyme activity; human; human cell; in vitro study; keratinocyte; nonhuman; plant leaf; RAW 264.7 cell line; time factor; Flavonoids | English | 2020 | 2020-02 | 10.1007/s12257-019-0259-3 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Inhibitory Functions of Novel Compounds from Dioscorea batatas Decne Peel on HMGB1-mediated Septic Responses | Inhibition of high mobility group box 1 (HMGB1) signaling and restoration of endothelial integrity are emerging as promising therapeutic strategies for managing severe vascular inflammatory diseases. Dioscorea batatas Decne (DBD, Chinese yam), a perennial plant which belongs to Dioscoreaceae, is widely cultivated across Korea, Japan, China, and other tropical and subtropical regions, and both the aerial parts and roots of this plant are used for food and medicinal purposes. Here, we determined the effects of the two phenanthrene compounds from DBD peel, 2,7-dihydroxy-4,6-dimethoxyphenanthrene (1) and 6,7-dihydroxy-2,4-dimethoxyphenanthrene (2), on HMGB1-mediated septic responses and survival rate in cecal ligation and puncture (CLP)-induced septic model. The anti-inflammatory activities of compounds 1 and 2 were monitored by lipopolysaccharide (LPS)- or CLP-induced release of HMGB1. The anti-septic activities of compounds 1 and 2 were determined by measuring permeability, leukocyte adhesion and migration, and pro-inflammatory protein activation in HMGB1-activated human umbilical vein endothelial cells (HUVECs) and mice. Compounds 1 and 2 inhibited HMGB1 release and downregulated HMGB1-mediated inflammatory responses in HUVECs. Compounds 1 and 2 also inhibited HMGB1-induced hyperpermeability and leukocyte migration in mice. Additionally, treatment with compounds 1 and 2 reduced CLP-induced HMGB1 release and sepsis-related mortality and pulmonary damage in vivo. Our results indicate that the compounds 1 and 2 are potential therapeutic agents for treating severe vascular inflammatory diseases via HMGB1 signaling pathway inhibition. | Jeong, So Yeon; Kim, Minyoul; Park, Eui Kyun; Kim, Jong-Sang; Hahn, Dongyup; Bae, Jong-Sup | Kyungpook Natl Univ, Coll Pharm, BK21 Plus KNU Multiom Based Creat Drug Res Team, Pharmaceut Sci Res Inst,CMRI, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Coll Agr & Life Sci, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Pathol & Regenerat Med, Sch Dent, Daegu 41940, South Korea; Kyungpook Natl Univ, Inst Agr Sci & Technol, Coll Agr & Life Sci, Daegu 41566, South Korea | Bae, Jong-Sup/AAU-9724-2020 | 58443839300; 57209449244; 37071072400; 37106950100; 36554163400; 16021543200 | dohahn@knu.ac.kr;baejs@knu.ac.kr; | BIOTECHNOLOGY AND BIOPROCESS ENGINEERING | BIOTECHNOL BIOPROC E | 1226-8372 | 1976-3816 | 25 | 1 | SCIE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | 2020 | 2.836 | 58.8 | 1.9 | 2025-06-25 | 30 | 30 | Dioscorea batatas Decne peel; endothelium; HMGB1; sepsis | RESVERATROL; HMGB1; SEPSIS | Dioscorea batatas Decne peel; endothelium; HMGB1; sepsis | Antennas; Cell adhesion; Endothelial cells; Mammals; Tropics; 2,7 dihydroxy 4,6 dimethoxyphenanthrene; 6,7 dihydroxy 2,4 dimethoxyphenanthrene; alanine aminotransferase; antiinflammatory agent; aspartate aminotransferase; creatinine; herbaceous agent; high mobility group B1 protein; immunoglobulin enhancer binding protein; interleukin 6; lactate dehydrogenase; mitogen activated protein kinase 1; mitogen activated protein kinase 3; mitogen activated protein kinase p38; nitrogen; phenanthrene derivative; protective agent; protein inhibitor; transcription factor RelA; tumor necrosis factor; unclassified drug; urea; Anti-inflammatory activity; endothelium; High-mobility groups; HMGB1; Human umbilical vein endothelial cells; Inflammatory disease; Inflammatory response; sepsis; alanine aminotransferase blood level; animal cell; animal experiment; animal model; animal tissue; antiinflammatory activity; Article; aspartate aminotransferase blood level; cecal ligation and puncture-induced sepsis; cell membrane permeability; cell viability; controlled study; creatinine blood level; cytokine production; Dioscorea polystachya; down regulation; drug determination; drug isolation; drug structure; enzyme linked immunosorbent assay; enzyme phosphorylation; human; human cell; in vitro study; in vivo study; inflammation; lactate dehydrogenase blood level; leukocyte adherence; leukocyte migration; lipopolysaccharide-induced sepsis; lung injury; lung parenchyma; lung structure; male; mortality; mouse; nonhuman; overall survival; protein secretion; signal transduction; single drug dose; survival rate; umbilical vein endothelial cell; urea nitrogen blood level; Diseases | English | 2020 | 2020-02 | 10.1007/s12257-019-0382-1 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Intravascular modality-guided versus angiography-guided percutaneous coronary intervention in acute myocardial infarction | Background Few data are available for current usage patterns of intravascular modalities such as intravascular ultrasound (IVUS), optical coherence tomography (OCT), and fractional flow reserve (FFR) in acute myocardial infarction (AMI). Moreover, patient and procedural-based outcomes related to intravascular modality guidance compared to angiography guidance have not been fully investigated yet. Methods We examined 11,731 patients who underwent percutaneous coronary intervention (PCI) from the Korea AMI Registry-National Institute of Health database. Patient-oriented composite endpoint (POCE) was defined as all-cause death, any infarction, and any revascularization. Device-oriented composite endpoint (DOCE) was defined as cardiac death, target-vessel reinfarction, and target-lesion revascularization. Results Overall, intravascular modalities were utilized in 2,659 (22.7%) patients including 2,333 (19.9%) IVUS, 277 (2.4%) OCT, and 157 (1.3%) FFR. In the unmatched cohort, POCE (5.4 vs. 8.5%; adjusted hazard ratio (HR) 0.75; 95% confidence interval (CI) 0.61-0.93; p = .008) and DOCE (4.6 vs. 7.4%; adjusted HR 0.77; 95% CI 0.61-0.97; p = .028) were significantly lower in intravascular modality-guided PCI compared with angiography-guided PCI. In the propensity-score-matched cohorts, POCE (5.9 vs. 7.7%; HR 0.74; 95% CI 0.60-0.92; p = .006) and DOCE (5.0 vs. 6.8%; HR 0.72; 95% CI 0.57-0.90; p = .004) were significantly lower in intravascular modality guidance compared with angiography guidance. The difference was mainly driven by reduced all-cause mortality (4.4 vs. 7.0%; p < .001) and cardiac mortality (3.3 vs. 5.2%; p < .001). Conclusion In this large-scale AMI registry, intravascular modality guidance was associated with an improving clinical outcome in selected high-risk patients. | Kim, Namkyun; Lee, Jang Hoon; Jang, Se Yong; Hwan, Myung; Yang, Dong Heon; Park, Hun Sik; Cho, Yongkeun; Jeong, Myung Ho; Park, Jong-Seon; Kim, Hyo-Soo; Hur, Seung-Ho; Seong, In-Whan; Cho, Myeong-Chan; Kim, Chong-Jin; Chae, Shung Chull | Kyungpook Natl Univ Hosp, Dept Internal Med, 130 Dongdeok Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Daegu, South Korea; Chonnam Natl Univ Hosp, Dept Internal Med, Gwangju, South Korea; Yeungnam Univ Hosp, Dept Internal Med, Daegu, South Korea; Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea; Keimyung Univ, Dept Internal Med, Dongsan Med Ctr, Daegu, South Korea; Chungnam Natl Univ Hosp, Dept Internal Med, Daejeon, South Korea; Chungbuk Natl Univ Hosp, Dept Internal Med, Cheongju, South Korea; Kyung Hee Univ, Dept Internal Med, East West Neo Med Ctr, Seoul, South Korea | Kim, Jin Sug/AAY-6890-2021; Park, Hang-soo/AEH-1640-2022; Kim, Hyo/J-2753-2012 | 55887032700; 54581258000; 57207977889; 36607356800; 35277423400; 57198844106; 9249593500; 56485157500; 15763054600; 33567809200; 34570274500; 35254371300; 7401727518; 35229511500; 7101962036 | ljhmh75@knu.ac.kr; | CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS | CATHETER CARDIO INTE | 1522-1946 | 1522-726X | 95 | 4 | SCIE | CARDIAC & CARDIOVASCULAR SYSTEMS | 2020 | 2.692 | 58.8 | 2.12 | 2025-06-25 | 30 | 31 | acute myocardial infarction; angiography; fractional flow reserve; intravascular ultrasound; optical coherence tomography; prognosis | FRACTIONAL FLOW RESERVE; OPTICAL COHERENCE TOMOGRAPHY; ELUTING STENT IMPLANTATION; ULTRASOUND; METAANALYSIS; PCI; GUIDANCE; OUTCOMES; THERAPY; SOCIETY | acute myocardial infarction; angiography; fractional flow reserve; intravascular ultrasound; optical coherence tomography; prognosis | Aged; Cause of Death; Coronary Angiography; Coronary Artery Disease; Databases, Factual; Female; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Predictive Value of Tests; Prospective Studies; Radiography, Interventional; Recurrence; Registries; Republic of Korea; Risk Assessment; Risk Factors; Time Factors; Treatment Outcome; Ultrasonography, Interventional; acute heart infarction; adult; all cause mortality; angiography; Article; device oriented composite endpoint; female; fractional flow reserve; heart death; heart muscle revascularization; heart reinfarction; high risk patient; human; intravascular ultrasound; Korea; major clinical study; male; optical coherence tomography; patient oriented composite endpoint; percutaneous coronary intervention; register; target lesion revascularization; treatment outcome; adverse event; aged; cause of death; clinical trial; comparative study; coronary angiography; coronary artery disease; diagnostic imaging; factual database; heart infarction; interventional radiology; interventional ultrasonography; middle aged; mortality; multicenter study; predictive value; prospective study; recurrent disease; risk assessment; risk factor; South Korea; time factor | English | 2020 | 2020-03-01 | 10.1002/ccd.28359 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Novel Herbal Medicine C-KOK Suppresses the Inflammatory Gene iNOS via the Inhibition of p-STAT-1 and NF-κB | Cheong-Pye-Ko (CPK) and Kyung-Ok-Ko (KOK) are traditional herbal medicine prescriptions that have been used in oriental medicine as tonics for pulmonary-related diseases for centuries. However, the effects of a mixture of CPK and KOK (C-KOK) on cytokine-mediated pulmonary damage have not yet been elucidated. This study used lipopolysaccharide (LPS)-activated human pulmonary artery endothelial cells (HPAECs) to examine the effects of C-KOK on the induction of heme oxygenase-1 (HO-1) and the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Moreover, a mouse model was used to determine if C-KOK affected the expression of tumor necrosis factor (TNF)-alpha and iNOS in the lung tissues of LPS-treated mice. The results showed that C-KOK induced the translocation of Nrf2 from the cytosol to the nucleus by increasing Nrf2-antioxidant response elements (ARE) activity, increased the expression of HO-1, and decreased IL-1 beta and iNOS/NO production in the LPS-activated HPAECs. Specifically, the suppression of iNOS/NO expression from the administration of C-KOK was reversed by the RNAi knockdown of HO-1. In conclusion, these findings indicated that C-KOK produced a critical anti-inflammatory effect due to its HO-1 dependent downregulation of p-STAT-1 and NF-kappa B and the resultant inhibition of iNOS and also suggested that TNF-alpha was a potential target for HO-1. Therefore, the administration of C-KOK showed efficacy and might be a novel approach for the treatment of inflammatory pulmonary disease. | Lee, In-Chul; Ryu, Chang-Woo; Bae, Jong-Sup | Seowon Univ, Dept Cosmet Sci & Technol, Cheongju 28674, South Korea; Dongsan Wonoetangjeonsil, Daegu 41472, South Korea; Kyungpook Natl Univ, Coll Pharm, CMRI,Pharmaceut Sci Res Inst, BK21 Plus KNU Multiomics Based Creat Drug Res Tea, Daegu 41566, South Korea | Bae, Jong-Sup/AAU-9724-2020; Ryu, Chang/IAJ-9854-2023 | 56390536600; 57217633459; 16021543200 | baejs@knu.ac.kr; | BIOTECHNOLOGY AND BIOPROCESS ENGINEERING | BIOTECHNOL BIOPROC E | 1226-8372 | 1976-3816 | 25 | 4 | SCIE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | 2020 | 2.836 | 58.8 | 1.24 | 2025-06-25 | 20 | 20 | C-KOK; endothelium; iNOS; p-STAT-1 | CARBON-MONOXIDE; RELEASE; COX-2; MODEL | C-KOK; endothelium; iNOS; p-STAT-1 | Cell death; Endothelial cells; Mammals; Medicine; Nitric oxide; antiinflammatory agent; cheong pye ko; cyclooxygenase 2; heme oxygenase 1; herbaceous agent; immunoglobulin enhancer binding protein; inducible nitric oxide synthase; interleukin 1beta; kyung ok ko; messenger RNA; nitric oxide; prostaglandin E2; small interfering RNA; STAT1 protein; transcription factor Nrf2; tumor necrosis factor; unclassified drug; Anti-inflammatory effects; Antioxidant response elements; Inducible nitric oxide synthase (iNOS); Inflammatory genes; Lipopolysaccharides; Oriental medicines; Pulmonary artery endothelial cells; Tumor necrosis factors; animal experiment; animal model; animal tissue; antiinflammatory activity; antioxidant responsive element; Article; bronchoalveolar lavage fluid; cell viability; controlled study; down regulation; experimental lung injury; gene knockdown; herbal medicine; human; human cell; lipopolysaccharide-induced lung inflammation; lung endothelium; lung parenchyma; mouse; mRNA expression level; nonhuman; protein expression level; protein phosphorylation; pulmonary artery; RNA interference; upregulation; Plant extracts | English | 2020 | 2020-08 | 10.1007/s12257-020-0126-2 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Perseverative stereotypic behavior of Epac2 KO mice in a reward-based decision making task | Successfully navigating dynamic environments requires balancing the decision to stay at an optimal choice with that to switch to an alternative to acquire new knowledge. However, the genetic factors and cellular activity shaping this "stay or switch" action decision remains largely unidentified. Here we find that mice carrying a deletion of the exchange protein directly activated by cAMP 2 (Epac2) gene, a putative autism locus, exhibit perseverative "stay" behavior in a dynamic foraging task. Anatomical analysis found that the loss of Epac2 resulted in a significant decrease in the density of PV-expressing interneurons in the ventrolateral orbitofrontal cortex (OFC) and dorsal striatum (dSTR). Further, in vitro whole cell patch clamp recordings of PV+ GABAergic interneurons in the dSTR revealed altered neural activity in Epac2 KO mice in response to dopamine. Our findings highlight a potential role of Epac2 in structural changes and neural responses of PV-expressing GABAergic interneurons in the ventrolateral OFC and dSTR during value-based reinforcement learning and link Epac2 function to abnormal decision-making processes and perseverative behaviors seen in autism. (C) 2020 Elsevier B.V. and Japan Neuroscience Society. All rights reserved. | Roh, Mootaek; Lee, Hyunjung; Seo, Hyunhyo; Lim, Chae-Seok; Park, Pojeong; Choi, Ja Eun; Kwak, Ji-Hye; Lee, Juhyun; Kaang, Bong-Kiun; McHugh, Thomas J.; Lee, Kyungmin | Kyungpook Natl Univ, Sch Med, Brain Sci & Engn Inst, Dept Anat, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Seoul Natl Univ, Sch Biol Sci, 1 Gwanangno, Seoul 08826, South Korea; Wonkwang Univ, Sch Med, Dept Pharmacol, 460 Iksandae Ro, Iksan 54538, Jeonbuk, South Korea; RIKEN, Ctr Brain Sci, Lab Circuit & Behav Physiol, Wako, Saitama 3510198, Japan | SEO, Hyunhyo/AAR-6343-2021; park, pojeong/AAT-1716-2021; McHugh, Thomas/A-6693-2010; Choi, Ja Eun/HTR-6298-2023 | 55352054500; 55706786600; 56611228800; 7403654010; 55944871400; 57194772568; 56689173300; 57219315346; 7003889686; 7007165049; 57211016316 | thomas.mchugh@riken.jp;irislkm@knu.ac.kr; | NEUROSCIENCE RESEARCH | NEUROSCI RES | 0168-0102 | 1872-8111 | 161 | SCIE | NEUROSCIENCES | 2020 | 3.322 | 58.8 | 0.22 | 2025-06-25 | 3 | 3 | Epac2; Stay-switch decision-making; Orbitofrontal cortex; Striatum; Parvablumin-expressing GABAergic interneurons; Fast-spiking interneurons | ORBITOFRONTAL CORTEX; BASAL GANGLIA; MECHANISMS; DOPAMINE; NEURONS; EXCITATION/INHIBITION; PREDICTION; SELECTION; AMYGDALA; CHOICES | Epac2; Fast-spiking interneurons; Orbitofrontal cortex; Parvablumin-expressing GABAergic interneurons; Stay-switch decision-making; Striatum | Animals; Decision Making; Dopamine; Interneurons; Mice; Patch-Clamp Techniques; Prefrontal Cortex; Reward; 4 aminobutyric acid receptor; dopamine; exchange protein directly activated by camp 2; protein; unclassified drug; dopamine; animal cell; animal experiment; animal tissue; Article; cell density; controlled study; decision making task; dorsal striatum; foraging behavior; gene loss; immunohistochemistry; in vitro study; interneuron; knockout mouse; male; mouse; nerve potential; nonhuman; orbital cortex; priority journal; reward; stereotypy; whole cell patch clamp; animal; decision making; interneuron; patch clamp technique; prefrontal cortex | English | 2020 | 2020-12 | 10.1016/j.neures.2020.08.010 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Inhibitory effects of orientin in mast cell-mediated allergic inflammation | Background Mast cells are immune effector cells mediating allergic inflammation by the secretion of inflammatory mediators such as histamine and pro-inflammatory cytokines. Orientin is a naturally occurring bioactive flavonoid that possesses diverse biological properties, including anti-inflammation, anti-oxidative, anti-tumor, and cardio protection. The objective of this study was to rule out the effectiveness of orientin in mast cell-mediated allergic inflammation. Methods In this study, in vitro effects of orientin were evaluated in RBL-2H3, mouse bone marrow-derived mast cells, rat peritoneal mast cells, and in vivo effects were evaluated by inducing passive cutaneous anaphylaxis (PCA) in Imprinting Control Region (ICR) mice. Results Findings show that orientin suppressed the immunoglobulin E (IgE)-mediated mast cell degranulation by reducing intracellular calcium level in a concentration-dependent manner. Orientin suppressed the secretion of pro-inflammatory cytokines in mast cells. This inhibitory effects of orientin was through inhibition of Fc epsilon RI-mediated signaling proteins. In addition, oral administration of orientin suppressed the IgE-mediated PCA reactions in a dose-dependent manner, which was evidenced by reduced Evan's blue pigmentation and ear swelling. Conclusions Based on these findings, we suggest that orientin might have potential to alleviate allergic reaction and mast cell-mediated allergic disease. | Dhakal, Hima; Lee, Soyoung; Choi, Jin Kyeong; Kwon, Taeg Kyu; Khang, Dongwoo; Kim, Sang-Hyun | Kyungpook Natl Univ, Sch Med, Cell & Matrix Res Inst, Dept Pharmacol, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Korea Res Inst Biosci & Biotechnol, Immunoregulatory Mat Res Ctr, Jeongeup, South Korea; NEI, Mol Immunol Sect, Lab Immunol, NIH, Bethesda, MD 20892 USA; Keimyung Univ, Sch Med, Dept Immunol, Daegu, South Korea; Gachon Univ, Sch Med, Dept Physiol, 191 Hambangmoe Ro, Incheon, South Korea | 57195999763; 8537269200; 50261279600; 7202206057; 26039177500; 57210450420 | dkhang@gachon.ac.kr;shkim72@knu.ac.kr; | PHARMACOLOGICAL REPORTS | PHARMACOL REP | 1734-1140 | 2299-5684 | 72 | 4 | SCIE | PHARMACOLOGY & PHARMACY | 2020 | 3.027 | 58.9 | 0.88 | 2025-06-25 | 20 | 17 | Mast cell; Allergic inflammation; Histamine; Passive cutaneous anaphylaxis; Orientin | HISTAMINE-RELEASE; FLAVONOIDS; TIME; DEGRANULATION; CYTOKINES; ROLES; TNF | Allergic inflammation; Histamine; Mast cell; Orientin; Passive cutaneous anaphylaxis | Animals; Anti-Allergic Agents; Anti-Inflammatory Agents; Cells, Cultured; Dose-Response Relationship, Drug; Flavonoids; Glucosides; Hypersensitivity; Inflammation Mediators; Male; Mast Cells; Mice; Mice, Inbred ICR; Rats; Rats, Sprague-Dawley; beta n acetylhexosaminidase; calcium; Fc epsilon receptor i; Fc receptor; histamine; immunoglobulin E; interleukin 4; orientin; tumor necrosis factor; unclassified drug; antiallergic agent; antiinflammatory agent; autacoid; flavonoid; glucoside; orientin; animal cell; antiallergic activity; Article; bone marrow derived mast cell; calcium cell level; controlled study; cross linking; cytokine release; dose response; histamine blood level; in vitro study; male; mast cell degranulation; mouse; nonhuman; passive skin anaphylaxis; peritoneum mast cell; protein phosphorylation; animal; cell culture; drug effect; hypersensitivity; immunology; Institute for Cancer Research mouse; mast cell; metabolism; rat; Sprague Dawley rat | English | 2020 | 2020-08 | 10.1007/s43440-019-00048-3 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Neuropsychiatric Traits Associated with Refractory Impulse Control Disorder in Parkinson's Disease | Introduction:Impulse control disorder (ICD) in Parkinson's disease (PD) is a critical nonmotor symptom with personality or neuropsychiatric traits contributing to ICD.Objective:This study aimed to identify predictive traits for persistent or paradoxical aggravation of ICD after dopamine agonist substitution therapy for ICD in PD.Methods:We conducted a case-control study using a database of a multicenter intervention trial for ICD in PD. The poor-outcome group was defined by showing paradoxical increases in ICD behaviors after the substitution of dopamine agonists with levodopa. We analyzed the pre-intervention personality traits associated with the poor outcome and also evaluated the risk traits for refractory ICD using a receiver-operating characteristic (ROC) curve analysis.Results:The poor-outcome group showed higher levels of anger expression (p =0.007) and obsessive-compulsive traits (p =0.009) compared with the good-outcome group at the pre-intervention state. In the ROC curve analysis, the Obsessive-Compulsive Inventory showed the highest area under the curve with 80.0% sensitivity and 74.3% specificity in discriminating against the poor-outcome group.Conclusions:Our results suggest that assessment of obsessive compulsiveness may be useful for predicting the refractoriness of ICD behaviors in planning an interventional treatment for ICD in PD. | Choi, Ji-Hyun; Lee, Jee-Young; Jeon, Beomseok; Koh, Seong-Beom; Yoon, Won Tae; Lee, Ho-Won; Kwon, Oh Dae; Kim, Jae Woo; Kim, Jong-Min; Ma, Hyeo-Il; Kim, Hee Tae; Baik, Jong Sam; Cho, Jin Whan | Seoul Natl Univ, Seoul Metropolitan Govt, Dept Neurol, Boramae Med Ctr,Coll Med, 20 Boramae Ro 5 Gil, Seoul 07061, South Korea; Seoul Natl Univ, Seoul Natl Univ Hosp, Dept Neurol, Coll Med, Seoul, South Korea; Korea Univ, Dept Neurol, Guro Hosp, Seoul, South Korea; Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Neurol, Sch Med, Seoul, South Korea; Kyungpook Natl Univ, Dept Neurol, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu, South Korea; Daegu Catholic Univ, Dept Neurol, Med Ctr, Daegu, South Korea; Dong A Univ Hosp, Dept Neurol, Pusan, South Korea; Seoul Natl Univ, Coll Med, Dept Neurol, Bundang Hosp, Seongnam, South Korea; Hallym Univ Hosp, Dept Neurol, Anyang, South Korea; Hanyang Univ, Dept Neurol, Med Ctr, Seoul, South Korea; Inje Univ, Dept Neurol, Sanggye Paik Hosp, Seoul, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Neurol, Sch Med, 81 Ilwon Ro, Seoul 06351, South Korea | ; Kwon, Oh/X-4963-2018; Kim, Jong-Min/J-5435-2012; Lee, Jae/AAD-3704-2019; Kwon, Oh Dae/X-4963-2018 | 57199099845; 36062860800; 7102161956; 8573789300; 13204609700; 35337240700; 56680571800; 56184412500; 55784601300; 27467447200; 7410136705; 7006635133; 35084917900 | wieber04@snu.ac.kr;jinwhan.cho@samsung.com; | NEURODEGENERATIVE DISEASES | NEURODEGENER DIS | 1660-2854 | 1660-2862 | 19 | 5-6 | SCIE | CLINICAL NEUROLOGY;NEUROSCIENCES | 2020 | 2.977 | 58.9 | 0.32 | 2025-06-25 | 5 | 6 | Impulse control disorder; Parkinson's disease; Dopamine agonist; Neuropsychiatric traits; Obsessive compulsiveness | INTERMITTENT EXPLOSIVE DISORDER; BEHAVIORS | Dopamine agonist; Impulse control disorder; Neuropsychiatric traits; Obsessive compulsiveness; Parkinson's disease | Anger; Antiparkinson Agents; Case-Control Studies; Compulsive Behavior; Disruptive, Impulse Control, and Conduct Disorders; Dopamine Agonists; Female; Humans; Levodopa; Male; Middle Aged; Obsessive Behavior; Parkinson Disease; Risk Factors; Sensitivity and Specificity; Treatment Failure; dopamine receptor stimulating agent; levodopa; antiparkinson agent; dopamine receptor stimulating agent; levodopa; adult; Article; Barratt Impulsiveness Scale; Beck Anxiety Inventory; Beck Depression Inventory; case control study; clinical article; compulsive buying; data base; disease association; female; food addiction; Hoehn and Yahr scale; human; hypersexuality; impulse control disorder; male; mental disease; Mini Mental State Examination; multicenter study; obsessive compulsive disorder; outcome assessment; Parkinson disease; pathological gambling; personality; personality disorder; priority journal; State-Trait Anger Expression Inventory; substitution therapy; Unified Parkinson Disease Rating Scale; anger; clinical trial; complication; compulsion; impulse control disorder; middle aged; obsession; Parkinson disease; psychology; risk factor; sensitivity and specificity; treatment failure | English | 2020 | 2020-06 | 10.1159/000507447 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Review | What Shall We Do for the Patients with Shaky Leg Syndrome? A Review of 23 Patients | Orthostatic tremor (OT) is not an uncommon symptom in various neurodegenerative diseases. However, the nature and pathophysiology of OT involve a complex network of tremors and dopaminergic pathways. We assessed patients who complained of prominent leg tremors described as "shaky leg." We analyzed their characteristics and evaluated them with neuroimaging and electrophysiological tools. A total of 23 patients who experienced an uncomfortable symptom of leg tremor were retrospectively enrolled from April 2014 to October 2019. Previous medical history, brain MRI, and surface electromyography (EMG) data were analyzed. The [F-18]-FP-CIT brain positron emission tomography (PET) and the Unified Parkinson's Disease Rating Scale (UPDRS) were assessed for patients who showed parkinsonism. The causes of OT varied: parkinsonism (n= 5), idiopathic causes (n= 4), secondary causes (n= 3, trauma, brain lesion, arteriovenous malformation), drug reactions (n= 3, valproate, perphenazine, haloperidol), other neurological disorders (n= 5, essential tremor, dystonia, restless leg syndrome, REM sleep behavior disorder, dementia), alcohol withdrawal (n= 1), functional movement disorder (n= 1), and an unknown cause (n= 1). The frequency range varied (2.6-15 Hz) and according to the new consensus statement on the classification of OT, 4 patients had primary OT, 2 had "primary OT plus," 12 had slow OT, and 5 had orthostatic myoclonus. The prognosis associated with the use of medication was generally poor; however, clonazepam and levodopa were the most effective drugs. In conclusion, we found that different types of OT and orthostatic myoclonus were diagnosed by electrophysiological evaluation and neuroimaging tools even if they showed the same symptoms as "shaky leg." In addition, it is possible to roughly estimate the response to medication according to the type of OT and the cause. To clarify the pathophysiology of OT, a large number of longitudinal cohort studies and detailed neuroimaging and electrophysiological evaluations are needed. | Park, Sangmin; Lim, Jung Geol; Chang, Hee Jin; Oh, Eungseok | Kyungpook Natl Univ, Dept Neurol, Chilgok Hosp, Daegu, South Korea; Kyungpook Natl Univ, Neurosurg Ctr, Chilgok Hosp, Daegu, South Korea; Daejeon Vet Hosp, Dept Neurol, Daejeon, South Korea; Chungnam Natl Univ, Chungnam Natl Univ Hosp, Dept Neurol, Coll Med, 282 Munhwa Ro, Daejeon 35015, South Korea | JY, LEE/GRS-9767-2022; Oh, Eungseok/AAL-8935-2020 | 57197524938; 57219156979; 57731595800; 55833749700 | massive@cnuh.co.kr; | NEURODEGENERATIVE DISEASES | NEURODEGENER DIS | 1660-2854 | 1660-2862 | 20 | 1 | SCIE | CLINICAL NEUROLOGY;NEUROSCIENCES | 2020 | 2.977 | 58.9 | 0.24 | 2025-06-25 | 2 | 3 | Shaky leg; Orthostatic tremor; Parkinsonism | SLOW ORTHOSTATIC TREMOR; DOPAMINERGIC DEFICIT; SPINAL-CORD | Aged; Dizziness; Humans; Middle Aged; Neurodegenerative Diseases; Retrospective Studies; Tremor; clonazepam; haloperidol; levodopa; perphenazine; valproic acid; adult; aged; alcohol withdrawal syndrome; arteriovenous malformation; Article; brain damage; clinical article; clinical feature; drug efficacy; dystonia; electromyogram; female; hand tremor; human; leg disease; male; middle aged; motor dysfunction; myoclonus; onset age; parasomnia; parkinsonism; priority journal; restless legs syndrome; retrospective study; shaky leg syndrome; shaky leg syndrome; treatment response; degenerative disease; diagnostic imaging; dizziness; pathophysiology; tremor | English | 2020 | 2020-10 | 10.1159/000509411 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Acellular dermal matrix combined with oxidized regenerated cellulose for partial breast reconstruction Two case reports | Rationale: Filling materials for partial defect of the breast have rarely been developed because of safety and durability. Patient concerns: Two female patients (ages, 53 and 50 years) with breast cancer underwent partial mastectomy with sentinel lymph node biopsy. Diagnosis: Core needle biopsy revealed an invasive ductal carcinoma in both patients. Breast ultrasound showed hypoechoic nodules with irregular margins. Breast magnetic resonance imaging showed an irregularly shaped enhancing mass with duct extension in Patient 1 and irregularly shaped multifocal, enhancing masses with non-mass enhancement in Patient 2. Intervention: A combination method using acellular dermal matrix and oxidized regenerated cellulose was used for partial breast reconstruction. The safety and cosmetic outcomes were evaluated for both patients. Outcomes: There were no significant complications, and the breast shape and volume were well maintained, even 2 years after surgery. There was no postoperative tumor recurrence. Conclusion: The combination of acellular dermal matrix and oxidized regenerated cellulose for partial breast reconstruction can be a good option based on oncological safety and cosmetic outcome. | Lee, Jeeyeon; Yang, Jung Dug; Lee, Jeong Woo; Li, Junjie; Jung, Jin Hyang; Kim, Wan Wook; Park, Chan Sub; Lee, Joon Seok; Park, Ho Yong | Kyungpook Natl Univ, Sch Med, Dept Surg, Hoguk Ro 807, Daegu 41404, South Korea; Kyungpook Natl Univ, Sch Med, Dept Plast Surg, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Daegu, South Korea; Kyungpook Natl Univ Hosp, Daegu, South Korea; Sichuan Prov Canc Hosp, Dept Surg, Chengdu, Peoples R China; Kyungpook Natl Univ, Joint Inst Regenerat Med, Daegu, Peoples R China | Lee, Jong-Mok/KVY-9550-2024; PARK, JUN-YOUNG/P-5981-2015; Li, Junjie/KFA-8634-2024; LEE, JIN/Q-3108-2018; Yang, Jung/R-7806-2019 | 37079213100; 55171704700; 55892173700; 56115485100; 57209310173; 26023273400; 57208483662; 56496041000; 56564377200 | phy123@knu.ac.kr; | MEDICINE | MEDICINE | 0025-7974 | 1536-5964 | 99 | 31 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 1.889 | 59.0 | 0.64 | 2025-06-25 | 8 | 9 | acellular dermal matrix; breast; carcinoma; defect; oxidized regenerated cellulose | ABSORBABLE MESH INSERTION; CONSERVING SURGERY; PARTIAL MASTECTOMY; TUMOR LOCATION; FLAP; COMPLICATIONS; QUADRANT; IMPLANT; DONOR | acellular dermal matrix; breast; carcinoma; defect; oxidized regenerated cellulose | Acellular Dermis; Breast Neoplasms; Carcinoma, Ductal; Cellulose, Oxidized; Female; Humans; Mammaplasty; Mastectomy, Segmental; Middle Aged; Treatment Outcome; oxidized cellulose; acellular dermal matrix; breast reconstruction; breast tumor; case report; female; human; middle aged; Paget nipple disease; partial mastectomy; treatment outcome | English | 2020 | 2020-07-31 | 10.1097/md.0000000000021217 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Association between personality traits and suicidality by age groups in a nationally representative Korean sample | Suicide is a leading health issue, which substantially contributes to the causes of death worldwide. Personality traits are some of the major risk factors for suicidality. We sought to identify the relationships between personality traits and suicidality by age group. The Big-Five Inventory-10 traits were measured in community-dwelling individuals in a nationally representative sample in the Republic of Korea. Because personality traits are long-standing patterns throughout one's lifetime, suicidality was measured based on lifetime history, rather than in a recent period. To comprehensively examine independent influences of personality traits on suicidality, psychiatric comorbidity and sociodemographic data were adjusted for. A total of 6022 subjects (3714 females and 2308 males) were included. Agreeableness (odds ratio (OR) [95% confidential intervals (CI)] = 0.79 [0.64-0.98]) was negatively associated with suicidal ideation, whereas neuroticism (1.27 [1.05-1.54]) and openness (1.36 [1.11-1.67]) were positively associated with suicidal ideation among young adults. Openness (1.25 [1.10-1.43]) had a positive association, and conscientiousness (0.86 [0.75-0.98]) had a negative association with suicidal ideation among the middle-aged group. Neuroticism is the only influencing factor for suicidal attempts among the young adult (1.88 [1.24-2.86]) and older (1.65 [1.24-2.20]) groups. Given the differential associations between personality traits and suicidality by age groups, future studies are needed to comprehensively identify possible roles of personality in suicide by age. | Na, Kyoung-Sae; Cho, Seo-Eun; Hong, Jin Pyo; Lee, Jun-Young; Chang, Sung Man; Jeon, Hong Jin; Cho, Seong-Jin | Gachon Univ, Dept Psychiat, Gil Med Ctr, 21,774 Beon Gil, Incheon 21565, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Psychiat, Coll Med, Seoul, South Korea; Seoul Natl Univ, Boramae Hosp, Coll Med, Dept Psychiat & Behav Sci, Seoul, South Korea; Kyungpook Natl Univ, Dept Psychiat, Sch Med, Daegu, South Korea | Lee, Jun-Young/N-5963-2019; /W-1317-2019 | 14519767500; 37012446800; 55729426400; 56117898800; 23092756400; 35195917400; 55572091200 | sjcho@gilhospital.com; | MEDICINE | MEDICINE | 0025-7974 | 1536-5964 | 99 | 16 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 1.889 | 59.0 | 0.4 | 2025-06-25 | 6 | 10 | neuroticism; openness; personality; risk factors; suicide | ADULTS 50 YEARS; RISK-FACTORS; COMPLETED SUICIDE; IDEATION; DISORDERS; COMMUNITY; PERFECTIONISM; DEPRESSION; BEHAVIORS; SELF | Neuroticism; Openness; Personality; Risk factors; Suicide | adult; aged; alcoholism; anxiety disorder; Article; community dwelling person; comorbidity; conscientiousness; demography; educational status; female; groups by age; human; Korea; major clinical study; male; mental disease; middle aged; mood disorder; neurosis; openness; personality; priority journal; suicidal behavior; suicidal ideation; suicide attempt; tobacco dependence; young adult | English | 2020 | 2020-04 | 10.1097/md.0000000000019161 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Bilateral stellate ganglion block for migraine A case report | Rationale: Migraine is a recurrent, disabling neurovascular headache disorder. The patient's quality of life can be severely impaired by migraine attacks. Stellate ganglion block (SGB) can be used to relieve pain in the head, neck, and upper extremities. In the present cases, we performed SGB in 2 patients with migraine that responds poorly to drugs. Patient concerns: Patients 1 and 2 suffered from chronic, bilateral pulsating headache, accompanied by nausea and vomiting. Patient 1 presented with headache of 8 on the visual analog scale (VAS), and 37 on the migraine disability assessment (MIDAS). Patient 2 reported headache of 7 on the VAS, and 32 on the MIDAS. Diagnosis: The patients were diagnosed with migraine without aura based on the International Classification of Headache Disorders version 3. Interventions: Patient 1 was treated with bilateral SGB every week for a month and then every month for 3 months. Patient 2 received bilateral SGB every 2 weeks for a month and then every month for 3 months. Outcomes: Four months after SGB, patient 1 reported pain intensity of 4 on VAS and 6 on MIDAS and patient 2 rated pain intensity of 3 on VAS, and 6 on MIDAS, respectively. Lessons: The SGB can be an effective option to improve headache-related disability and relieve pain intensity in the patients with refractory migraine. | Moon, Suyoung; Lee, Joonhee; Jeon, Younghoon | Kyungpook Natl Univ, Sch Dent, Dept Anesthesiol & Pain Med, 130 Dongdeok Ro, Daegu 41944, South Korea | 59883370600; 57216962032; 21645921000 | Jeon68@gmail.com; | MEDICINE | MEDICINE | 0025-7974 | 1536-5964 | 99 | 18 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 1.889 | 59.0 | 0.32 | 2025-06-25 | 9 | 8 | headache; migraine; pain; stellate ganglion block; sympathetic nerve | INCREASES BLOOD-FLOW; HEADACHE | headache; migraine; pain; stellate ganglion block; sympathetic nerve | Adult; Autonomic Nerve Block; Disability Evaluation; Drug Administration Schedule; Female; Humans; Middle Aged; Migraine Disorders; Nausea; Quality of Life; Stellate Ganglion; Visual Analog Scale; Vomiting; adult; case report; complication; disability; drug administration; female; human; middle aged; migraine; nausea; nerve block; procedures; quality of life; stellate ganglion; visual analog scale; vomiting | English | 2020 | 2020-05 | 10.1097/md.0000000000020023 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Caudal block with steroid in the treatment of acute voiding dysfunction and pain caused by sacral herpes zoster A case report | Rationale: Herpes zoster (HZ) involving sacral dermatome is very rare, which can sometimes cause voiding dysfunction. Patient concerns: A 52-year-old man presented with acute pain and voiding dysfunction, following HZ in his right sacral dermatomes. Diagnoses: Twenty two days before presentation HZ occurred and 9 days after the onset of the HZ, he had trouble with starting urination and weak urine stream which was managed with tamsulosin 0.4 mg orally once a day and intermittent urinary catheterization. He was treated with 150 mg of pregabalin 2 times a day, tramadol 50 mg 2 times, and acetaminophen 600 mg 2 times a day. However, his pain intensity was 5 on the numerical analogue scale (NRS) from 0 (no pain) to 10 (worst pain imaginable). Interventions: Fluoroscopy guided caudal block was performed with a mixture of 0.5% lidocaine 10 mL and triamcinolone 40 mg. Outcomes: One day after the procedure, the pain decreased to 1 on the NRS score. In addition, voiding difficulty greatly improved. Three days after the intervention, the patient reported complete resolution of pain and voiding dysfunction. He currently remains symptom free at a 3-month follow-up. Lessons: A caudal block with steroid can be an effective option for treatment of acute voiding dysfunction and pain following sacral HZ. | Jeon, Younghoon; Jin, Yehun | Kyungpook Natl Univ, Sch Dent, Dept Anesthesiol & Pain Med, 130 Dongdeok Ro, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Dept Anesthesiol & Pain Med, Daegu, South Korea | 21645921000; 57215135774 | Jeon68@gmail.com; | MEDICINE | MEDICINE | 0025-7974 | 1536-5964 | 99 | 25 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 1.889 | 59.0 | 0.08 | 2025-06-25 | 2 | 1 | caudal block; herpes zoster; pain; sacral region; steroid; voiding dysfunction | POSTHERPETIC NEURALGIA; URINARY-RETENTION | caudal block; herpes zoster; pain; sacral region; steroid; voiding dysfunction | Anesthesia, Caudal; Anesthetics, Local; Fluoroscopy; Glucocorticoids; Herpes Zoster; Humans; Lidocaine; Male; Middle Aged; Neuralgia, Postherpetic; Pain Management; Pain Measurement; Sacrum; Tamsulosin; Triamcinolone; Urinary Bladder, Neurogenic; Urinary Catheterization; Urological Agents; glucocorticoid; lidocaine; local anesthetic agent; tamsulosin; triamcinolone; urinary tract agent; analgesia; bladder catheterization; case report; caudal anesthesia; complication; fluoroscopy; herpes zoster; human; male; middle aged; neurogenic bladder; pain measurement; postherpetic neuralgia; procedures; sacrum; virology | English | 2020 | 2020-06 | 10.1097/md.0000000000020680 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Comparison of the intraoperative analgesic efficacy between ultrasound-guided deep and superficial serratus anterior plane block during video-assisted thoracoscopic lobectomy A prospective randomized clinical trial | Background: The serratus anterior plane block (SAPB) is a novel method that provides lateral chest wall analgesia. There are 2 methods of SAPB; deep and superficial SAPB. Each of these methods has been demonstrated to provide effective perioperative analgesia in thoracic surgery. The aim of this study was to compare the intraoperative hemodynamic and analgesic benefits of deep versus superficial SAPB during video-assisted thoracic surgery (VATS) lobectomy. Methods: We performed a prospective, randomized, patient/assessor-blinded trial. We included patients who were 20 to 75 years of age and scheduled to undergo VATS lobectomy with American Society of Anesthesiologists physical status 1 or 2. Patients were randomly allocated to receive either ultrasound-guided deep SAPB (Group D) or superficial SAPB (Group S). The primary outcome was intraoperative remifentanil consumption. We also recorded intraoperative systolic blood pressure (SBP), heart rate (HR), emergence time, and doses of rescue drugs used to manage hemodynamic instability. Results: Data for 50 patients undergoing 3-port VATS lobectomy were analyzed. Intraoperative remifentanil consumption did not differ significantly between Group D (n = 25, 715.62 +/- 320.36 mu g) and group S (n = 25, 721.08 +/- 294.48 mu g) (P = .97). Additionally, there were no significant differences between the 2 groups in SBP and HR at any time point, emergence time, or amount of rescue drugs used. Conclusion: Our study suggests that the intraoperative analgesic efficacy is similar for deep and superficial SAPB during VATS lobectomy. | Moon, Suyoung; Lee, Jungwon; Kim, Hyuckgoo; Kim, Jeongeun; Kim, Jiseob; Kim, Saeyoung | Kyungpook Natl Univ, Sch Med, Dept Anesthesiol & Pain Med, 130 Dongdeok Ro, Daegu 41944, South Korea; Yeungnam Univ, Dept Anesthesiol & Pain Med, Coll Med, Daegu, South Korea; Keimyung Univ, Dept Anesthesiol & Pain Med, Sch Med, Daegu, South Korea | 57192156555; 57203911073; 56571641100; 57220078928; 55905150400; 36113916600 | saeyoungkim7@gmail.com; | MEDICINE | MEDICINE | 0025-7974 | 1536-5964 | 99 | 47 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 1.889 | 59.0 | 0.88 | 2025-06-25 | 21 | 23 | analgesia; intraoperative care; nerve block; thoracic surgery; ultrasonography; video-assisted | PARAVERTEBRAL BLOCK; EPIDURAL ANALGESIA; THORACIC-SURGERY; PAIN MANAGEMENT; RECOVERY; QUALITY | analgesia; intraoperative care; nerve block; thoracic surgery; ultrasonography; video-assisted | Aged; Analgesics, Opioid; Anesthesia Recovery Period; Blood Pressure; Double-Blind Method; Female; Heart Rate; Humans; Intraoperative Period; Male; Middle Aged; Nerve Block; Pneumonectomy; Prospective Studies; Remifentanil; Thoracic Surgery, Video-Assisted; Ultrasonography, Interventional; narcotic analgesic agent; remifentanil; aged; anesthetic recovery; blood pressure; comparative study; controlled study; double blind procedure; female; heart rate; human; interventional ultrasonography; intraoperative period; lung resection; male; middle aged; nerve block; procedures; prospective study; randomized controlled trial; video assisted thoracoscopic surgery | English | 2020 | 2020-11-20 | 10.1097/md.0000000000023214 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Comparison of Whitacre needle and Chiba needle on the incidence of intravascular injection during caudal epidural injections A single-blind, randomized clinical consort study | Caudal epidural injection (CEI) is effective for lumbar spinal pain. However, accidental intravascular injection reduces therapeutic efficacy of CEI and leads to fatal complications such as hematoma, and neurologic deficit. Whitacre needle has been reported to be effective for reducing intravascular injection during transforaminal epidural injection, compared with Quincke needle. The bevel of Chiba needle is shorter than that of Quincke needle. In this study we compared Whitacre needle and Chiba needle on incidence of intravascular injection during CEI. This was a single-blind, randomized clinical consort study. After institutional Review Board approval, a total of 164 patients underwent CEI were randomly allocated to one of 2 group (Whitacre needle or Chiba needle group). Intravascular injection was assessed with real-time fluoroscopy. In addition, total procedure time was measured. Data were compared between groups, and P < .05 was consideredstatistically significant. There were no differences between groups in terms of patient demographic and clinical characteristics. There was no significant difference on incidence of intravascular injection between Whitacre and Chiba needle group (11% vs 19.5%, P = .192). However, the procedure time is significantly longer in the Whitacre than Chiba needle group (172.8 +/- 53.8 sec vs 147.1 +/- 61.1 sec, P = .005). Based on current study, our results indicated that Whitacre needle was not effective to decrease the incidence of intravascular injection during CEI, compared to Chiba needle. | Lee, Jungwon; Kim, Saeyoung; Park, Sungsik; Kim, Sioh; Youn, Si-Jeong; Jeon, Younghoon | Yeungnam Univ, Med Ctr, Sch Med, Dept Anesthesiol & Pain Med, Daegu, South Korea; Kyungpook Natl Univ Hosp, Sch Med, Dept Anesthesiol & Pain Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Anesthesiol & Pain Med, 130 Dongdeok Ro, Daegu 41944, South Korea | 57203911073; 36113916600; 57210251038; 7601585407; 57221435350; 21645921000 | jeon68@gmail.com; | MEDICINE | MEDICINE | 0025-7974 | 1536-5964 | 99 | 51 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 1.889 | 59.0 | 0.16 | 2025-06-25 | 2 | 2 | caudal epidural injection; Chiba needle; complication; fluoroscopy; intravascular injection; Quincke needle; Whitacre needle | STEROID INJECTIONS; SHARP NEEDLES; BLUNT; ACCURACY; CATHETER; RISK | caudal epidural injection; Chiba needle; complication; fluoroscopy; intravascular injection; Quincke needle; Whitacre needle | Aged; Female; Fluoroscopy; Humans; Injections, Epidural; Male; Middle Aged; Needles; adverse device effect; adverse event; aged; comparative study; controlled study; devices; epidural drug administration; female; fluoroscopy; human; male; middle aged; needle; randomized controlled trial | English | 2020 | 2020-12-18 | 10.1097/md.0000000000023665 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Cytological, histological, and molecular characteristics of pure invasive micropapillary carcinoma of pancreas A case report | Introduction: Pure invasive micropapillary carcinoma (IMPC) is a rare histologic subtype of pancreatic cancer which has a high propensity for lymph node metastasis and poor prognosis. Patient concerns: An 81-year-old woman was admitted to our institution with a 3-month history of back pain. Computed tomography of the abdomen and pelvis confirmed the presence of a low-density mass in the tail of the pancreas. Diagnosis: Endoscopic ultrasound-guided fine needle aspiration cytology (FNAC) from the pancreatic mass showed small tumor cell clusters with three-dimensional aggregates and morula-like structures. The tumor was diagnosed as adenocarcinoma with micropapillary features. Interventions: The patient underwent radical antegrade modular pancreatosplenectomy and regional lymph node dissection. Histological examination showed small clusters of tumor cells that were closely adhered to one another. The cells were located in empty stromal spaces mimicking lymphovascular channels. All tumor cells showed reverse polarity, resulting in an "inside-out" pattern. An extensive search was performed, and no typical ductal adenocarcinoma component was found. The tumor measured 1.5 x 1.3cm and invaded into the peripancreatic fat tissue without adjacent organ invasion. One of the 12 regional lymph nodes showed metastasis. Ion Torrent next-generation sequencing identified missense mutations in KRAS, TP53, and SMAD4 using the Oncomine Comprehensive Panel version 1. Outcomes: Twelve months following surgical resection the patient remained healthy with no evidence of recurrence at clinical follow-up. Lessons: This report highlights the diagnostic features and molecular characteristics of pure pancreatic IMPC and the challenges with diagnosis by FNAC. A centralized and collaborative accumulation of additional cases of pure IMPC could further elucidate its pathogenesis. | Lee, Sun-Jae; Bae, Han-Ik; Yoon, Ghilsuk; Cho, Chang Min; Kwon, Hyung Jun; Park, Jongmin; Cho, Seung Hyun; Seo, An Na | Catholic Univ Daegu, Sch Med, Dept Pathol, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Pathol, 807 Hogukno, Daegu 41404, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Surg, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Cent Phys Examinat Off, Dept Radiol, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Radiol, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Radiol, Daegu, South Korea | 55597207600; 7103224222; 57204691355; 59273205400; 57199757347; 57216463879; 55686242700; 55804153700 | san_0729@naver.com; | MEDICINE | MEDICINE | 0025-7974 | 1536-5964 | 99 | 24 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 1.889 | 59.0 | 0 | 2025-06-25 | 1 | 1 | fine needle aspiration cytology; invasive micropapillary carcinoma; molecular pathology; next-generation sequencing; pancreas | ADENOCARCINOMA; ASSOCIATION; VARIANT; PATTERN | fine needle aspiration cytology; invasive micropapillary carcinoma; molecular pathology; next-generation sequencing; pancreas | Adenocarcinoma, Papillary; Aged, 80 and over; Female; Humans; Molecular Diagnostic Techniques; Neoplasm Invasiveness; Pancreatic Neoplasms; adenocarcinoma; case report; female; human; molecular diagnosis; pancreas tumor; pathology; tumor invasion; very elderly | English | 2020 | 2020-06 | 10.1097/md.0000000000020668 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
페이지 이동: