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WoS SCOPUS Document Type Document Title Abstract Authors Affiliation ResearcherID (WoS) AuthorsID (SCOPUS) Author Email(s) Journal Name JCR Abbreviation ISSN eISSN Volume Issue WoS Edition WoS Category JCR Year IF JCR (%) FWCI FWCI Update Date WoS Citation SCOPUS Citation Keywords (WoS) KeywordsPlus (WoS) Keywords (SCOPUS) KeywordsPlus (SCOPUS) Language Publication Stage Publication Year Publication Date DOI JCR Link DOI Link WOS Link SCOPUS Link
Article An Alternative Serological Measure for Assessing Foot-and-Mouth Disease Vaccine Efficacy against Homologous and Heterologous Viral Challenges in Pigs To analyze the relationship between homologous and heterologous serological titers of immunized pigs and their protection statuses against FMD virus challenges, in the present study, the correlation between the virus neutralization titers at 21 and 28 dpv and the protection statuses at 28 dpv against challenge with FMD virus was analyzed using data sets comprising five different combinations of homologous or heterologous challenge experiments in pigs vaccinated with type O (n = 96), A (n = 69), and Asia 1 (n = 74). As a result, the experiments were divided into three groups (21D-1, 21D-2, and 21D-3) in the 21-dpv model and two groups (28D-1 and 28D-2) in the 28-dpv model. Each response curve of groups 21D-1 and 21D-2 in the 21-dpv model was very similar to each curve of groups 28D-1 and 28D-2 in the 28-dpv model, respectively, even though there was an exceptional extra group (21D-3) in the 21-dpv model. The average titers estimating 0.75 probability of protection ranged from 1.06 to 1.62 log10 in the 21-dpv model and from 1.26 to 1.64 log10 in the 28-dpv model. In summary, we demonstrated that the serological method is useful for predicting the homologous and heterologous protection statuses of vaccinated pigs. Kim, Jaejo; Lee, Seung Heon; Kim, Ha-Hyun; Shin, Sung-Ho; Park, Sang-Hyun; Park, Jong-Hyeon; Park, Choi-Kyu Anim & Plant Quarantine Agcy, 177 Hyeoksin 8 Ro, Gimcheon City 39660, Gyeongsangbuk D, South Korea; Kyungpook Natl Univ, Coll Vet Med, Daegu 41566, South Korea; Kyungpook Natl Univ, Anim Dis Intervent Ctr, Daegu 41566, South Korea 36067760200; 57061932300; 12805065700; 57207356328; 57219557904; 55717103700; 24768064900 jkim1209@korea.kr;seungheon0117@korea.kr;hahy1202@naver.com;imshin121@korea.kr;shpark0205@korea.kr;parkjhvet@korea.kr;parkck@knu.ac.kr; VACCINES VACCINES-BASEL 2076-393X 12 1 SCIE IMMUNOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL 2024 3.4 38.2 2.05 2025-04-16 3 3 foot-and-mouth disease; vaccination; indirect potency test; virus neutralization antibody; estimating the protection status VIRUS-VACCINE; FIELD VIRUS; POTENCY; PROTECTION; CATTLE; TRANSMISSION; INFECTION; SEROTYPE; STRAINS; VARIABILITY estimating the protection status; foot-and-mouth disease; indirect potency test; vaccination; virus neutralization antibody foot and mouth disease vaccine; virus vaccine; antibody titer; Article; cytopathogenic effect; foot and mouth disease; Foot and mouth disease virus; humoral immunity; nonhuman; pig; predictive value; protection; receiver operating characteristic; scoring system; serotype; vaccination; virus neutralization English 2024 2024-01 10.3390/vaccines12010010 바로가기 바로가기 바로가기 바로가기
Article Evaluation of Swine Protection with Three Commercial Foot-and-Mouth Disease Vaccines against Heterologous Challenge with Type A ASIA/G-VII Lineage Viruses Outbreaks caused by foot-and-mouth disease (FMD) A/ASIA/G-VII lineage viruses have often occurred in Middle Eastern and Southeast Asian countries since 2015. Because A/ASIA/G-VII lineage viruses are reported to have distinct antigenic relatedness with available commercial FMD vaccine strains, it is necessary to investigate whether inoculation with vaccines used in Korea could confer cross-protection against A/ASIA/G-VII lineage viruses. In the present study, we conducted two vaccination challenge trials to evaluate the efficacy of three commercial FMD vaccines (O/Manisa + O/3039 + A/Iraq, O/Campos + A/Cruzeiro + A/2001, and O/Primorsky + A/Zabaikalsky) against heterologous challenge with ASIA/G-VII lineage viruses (A/TUR/13/2017 or A/BHU/3/2017 strains) in pigs. In each trial, clinical signs, viremia, and salivary shedding of virus were measured for 7 days after challenge. In summary, the O/Campos + A/Cruzeiro + A/2001 vaccine provided full protection against two A/ASIA/G-VII lineage viruses in vaccinated pigs, where significant protection was observed. Although unprotected animals were observed in groups vaccinated with O/Manisa + O/3039 + A/Iraq or O/Primorsky + A/Zabaikalsky vaccines, the clinical scores and viral RNA levels in the sera and oral swabs of vaccinated animals were significantly lower than those of unvaccinated controls. Kim, Seon Woo; Lee, Seung Heon; Kim, Ha-Hyun; Shin, Sung-Ho; Park, Sang-Hyun; Park, Jong-Hyeon; Kim, Jaejo; Park, Choi-Kyu Anim & Plant Quarantine Agcy, 177 Hyeoksin 8-Ro, Gimcheon 39660, Gyeongsangbug D, South Korea; Chonnam Natl Univ, Med Sch, Lab Anim Facil, Hwasun 58128, Jeonranam Do, South Korea; Kyungpook Natl Univ, Coll Vet Med, Anim Dis Intervent Ctr, 80 Daehak Ro, Daegu 41566, South Korea Kim, Seonwoo/KDO-4303-2024 57827319400; 57061932300; 12805065700; 57207356328; 57219557904; 55717103700; 36067760200; 24768064900 oneway0118@korea.kr;seungheon0117@korea.kr;hahyun@jnu.ac.kr;imshin121@korea.kr;shpark0205@korea.kr;parkjhvet@korea.kr;jkim1209@korea.kr;parkck@knu.ac.kr; VACCINES VACCINES-BASEL 2076-393X 12 5 SCIE IMMUNOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL 2024 3.4 38.2 0 2025-05-07 0 0 foot-and-mouth disease; vaccination; efficacy test; vaccine matching; virus neutralization antibody; vaccination challenge test MIDDLE-EAST; EMERGENCE; SEROTYPE efficacy test; foot-and-mouth disease; vaccination; vaccination challenge test; vaccine matching; virus neutralization antibody foot and mouth disease vaccine; virus RNA; animal experiment; Article; cellular immunity; controlled study; cytopathogenic effect; foot and mouth disease; Foot and mouth disease virus; genetic distance; herd immunity; immunization; inoculation; Iraq; linear regression analysis; nonhuman; pig; pilot study; real time polymerase chain reaction; Southeast Asian; swine protection; vaccination; vaccination challenge test; viremia; virus genome; virus load; virus neutralization; virus replication; virus shedding English 2024 2024-05 10.3390/vaccines12050476 바로가기 바로가기 바로가기 바로가기
Article How does the consecutive use of intraoral scanners affect musculoskeletal health? A preliminary clinical study Background Minimizing muscle strain and reducing the risk of musculoskeletal disorders associated with intraoral scanner (IOS) usage require ergonomic awareness, device selection, and workplace adjustments in dental practice. This preliminary clinical study aimed to simulate intraoral scanning tasks using wired and wireless IOSs and assess muscle activation and fatigue for both types. Materials and methods Fourteen participants performed intraoral scanning tasks using wired and wireless IOSs (i700; MEDIT), with weights of 280 g and 328 g, respectively. The same computer system and software conditions were maintained for both groups (N = 14 per IOS group). Electrodes were placed on arm, neck, and shoulder muscles, and maximal voluntary contraction (MVC) was measured. Surface electromyography (EMG) was performed during the simulation, and EMG values were normalized using MVC. The root mean square EMG (%MVC) and muscle fatigue (%) values were calculated. Statistical comparisons were performed using the Mann-Whitney U and Friedman tests, with the Bonferroni adjustment for multiple comparisons (alpha = 0.05). Results Arm (flexor digitorum superficialis) and neck muscles (left sternocleidomastoid and left splenius capitis) showed significantly higher EMG values with wireless IOS (P < 0.05). The neck (left sternocleidomastoid and right levator scapulae) and shoulder muscles (right trapezius descendens) demonstrated significantly higher muscle fatigue with wireless IOS (P < 0.05). Conclusions The consecutive use of heavier wireless IOS may increase the risk of muscle activation and fatigue in certain muscles, which may have clinical implications for dentists in terms of ergonomics and musculoskeletal health. Son, Keunbada; Lee, Ji-Min; Kim, Jin-Wook; Jin, Myoung-Uk; Lee, Kyu-Bok Kyungpook Natl Univ, Grad Sch, Dept Dent Sci, Adv Dent Device Dev Inst, Daegu 41940, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Oral & Maxillofacial Surg, Daegu, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Conservat Dent, Daegu, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Prosthodont, Daegu 41940, South Korea SON, Keunbada/AAG-8089-2019; Son, Keunbada/AAG-8089-2019; Lee, Ji Min/KCZ-2783-2024 57202916520; 57193811541; 55862646000; 56492091300; 15925571200 musljin@knu.ac.kr;kblee@knu.ac.kr; EUROPEAN JOURNAL OF MEDICAL RESEARCH EUR J MED RES 0949-2321 2047-783X 29 1 SCIE MEDICINE, RESEARCH & EXPERIMENTAL 2024 3.4 38.2 0 2025-05-07 0 0 Intraoral scanner; Musculoskeletal health; Surface electromyography; Muscle fatigue MUSCLE-ACTIVITY; SURFACE ELECTROMYOGRAPHY; POSTURE; CONTRACTIONS; RELIABILITY; DENTISTRY; POSITIONS; EXTENSOR; STOOL; FORCE Intraoral scanner; Muscle fatigue; Musculoskeletal health; Surface electromyography Adult; Electromyography; Ergonomics; Female; Humans; Male; Muscle Contraction; Muscle Fatigue; Muscle, Skeletal; Musculoskeletal Diseases; Young Adult; adult; electromyography; ergonomics; etiology; female; human; male; muscle contraction; muscle fatigue; musculoskeletal disease; pathophysiology; physiology; prevention and control; procedures; skeletal muscle; young adult English 2024 2024-06-15 10.1186/s40001-024-01895-4 바로가기 바로가기 바로가기 바로가기
Article Effects of antioxidants on skin hydration, inflammatory cytokines, and keratinocyte differentiation markers in a PM10-exposed skin barrier-disrupted mouse model Given that particulate matter (PM) has an established role in inducing oxidative stress, inflammation, and skin aging, it is plausible that PM could exacerbate inflammatory skin conditions such as xerosis. Xerosis represents a significant dermatological concern among older adults within aging populations. We conducted an investigation into the efficacy of antioxidants, such as dieckol, punicalagin, epigallocatechin gallate (EGCG), and resveratrol, against PM10 in a skin barrier-disrupted mouse model. A skin barrier-disrupted mouse model was induced by tape stripping. This study investigated the antioxidative and anti-inflammatory properties of antioxidants on PM-induced changes using the skin barrier-disrupted mouse model. Tape strips were attached to the back of 7-week-old nude mice and removed quickly. To investigate variations in skin hydration, levels of inflammatory cytokines, and indicators of keratinocyte differentiation, mice underwent treatment with several compounds: a control vehicle (100 mu L), PM10 100 mu L (100 mu g/mL), PM10 100 mu L (100 mu g/mL) with antioxidants 100 mu L (Punicalagin 5 mu M, Dieckol 5 mu M, EGCG 1 mu M, resveratol 1 mu M) for 1 week. To assess their effects, different analysis were conducted using measurements of skin moisture, real-time polymerase chain reaction, enzyme-linked immunosorbent assay for detecting inflammatory cytokines, and immunofluorescence staining to identify markers of keratinocyte differentiation. While PM10 decreased water content in disrupted skin, all antioxidants preserved skin hydration in the skin barrier-disrupted mice, regardless of the presence of PM10. All antioxidants also inhibited the upregulation of inflammatory cytokines, such as interleukin (IL)-1 beta, IL-4, IL-6, IL-8, and tumor necrosis factor-alpha and normalized the downregulation of keratinocyte differentiation markers against PM10 in skin barrier-disrupted mice. This study elucidated the protective effects of antioxidants-namely, punicalagin, dieckol, EGCG, and resveratrol-in mitigating the impact of PM10 on skin barrier integrity and inflammation in a disrupted skin barrier mouse model, highlighting their potential utility in dermatological treatments. Kim, Jin Ho; Kwack, Mi Hee; Lee, Weon Ju Kyungpook Natl Univ, Sch Med, Dept Dermatol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Immunol, Daegu, South Korea 58508499500; 6507685557; 24474659000 weonju@knu.ac.kr; INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY INT J IMMUNOPATH PH 0394-6320 2058-7384 38 SCIE IMMUNOLOGY;PATHOLOGY;PHARMACOLOGY & PHARMACY 2024 2.6 38.3 0 2025-05-07 0 0 antioxidants; particulate matter; xeroderma AIRBORNE PARTICULATE MATTER; REPAIR antioxidants; particulate matter; xeroderma Animals; Antioxidants; Biomarkers; Cell Differentiation; Cytokines; Disease Models, Animal; Keratinocytes; Mice; Mice, Nude; Particulate Matter; Skin; antioxidant; cytokine; dieckol; epigallocatechin gallate; interleukin 1beta; interleukin 4; interleukin 6; interleukin 8; punicalagin; resveratrol; tumor necrosis factor; unclassified drug; antioxidant; biological marker; cytokine; aging; animal experiment; animal model; animal tissue; Article; cell differentiation; controlled study; cutaneous parameters; dermatitis; down regulation; enzyme linked immunosorbent assay; female; hydration; immunofluorescence; immunohistochemistry; inflammation; keratinocyte; male; moisture; mouse; nonhuman; oxidative stress; particulate matter 10; real time polymerase chain reaction; skin; skin disease; upregulation; water content; xeroderma; xerosis; animal; disease model; drug effect; metabolism; nude mouse; particulate matter; pathology; toxicity English 2024 2024 10.1177/03946320241303860 바로가기 바로가기 바로가기 바로가기
Meeting Abstract A study for every second day administration of tegoprazan for maintenance treatment of non-erosive reflux disease: A randomized, multicenter, double-blind, active controlled study Kwon, Joong Goo; Bae, June Hwa; Jo, Hyeong Ho; Kim, Eun Young; Kwon, Yong Hwan; Jeon, Seong Woo; Chung, Yun Jin; Lee, Ju Yup; Park, Kyung Sik; Lee, Si Hyung Daegu Catholic Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Dept Internal Med, Sch Med, Daegu, South Korea; Keimyung Univ, Dept Internal Med, Sch Med, Daegu, South Korea; Yeungnam Univ, Dept Internal Med, Coll Med, Gyongsan, South Korea Lee, Hyun Woo/AAH-8473-2020; Lee, Si/ABH-1408-2020; Jo, Hyeong Ho/LFU-2981-2024; Kim, Eun-young/AAI-8613-2020; Jeon, Seongwoo/AAU-4618-2020 NEUROGASTROENTEROLOGY AND MOTILITY NEUROGASTROENT MOTIL 1350-1925 1365-2982 36 SCIE CLINICAL NEUROLOGY;GASTROENTEROLOGY & HEPATOLOGY;NEUROSCIENCES 2024 2.9 38.4 0 English 2024 2024-11 바로가기 바로가기
Article Cranial bone imaging using ultrashort echo-time bone-selective MRI as an alternative to gradient-echo based "black-bone" techniques ObjectivesCT is the clinical standard for surgical planning of craniofacial abnormalities in pediatric patients. This study evaluated three MRI cranial bone imaging techniques for their strengths and limitations as a radiation-free alternative to CT.MethodsTen healthy adults were scanned at 3 T with three MRI sequences: dual-radiofrequency and dual-echo ultrashort echo time sequence (DURANDE), zero echo time (ZTE), and gradient-echo (GRE). DURANDE bright-bone images were generated by exploiting bone signal intensity dependence on RF pulse duration and echo time, while ZTE bright-bone images were obtained via logarithmic inversion. Three skull segmentations were derived, and the overlap of the binary masks was quantified using dice similarity coefficient. Craniometric distances were measured, and their agreement was quantified.ResultsThere was good overlap of the three masks and excellent agreement among craniometric distances. DURANDE and ZTE showed superior air-bone contrast (i.e., sinuses) and soft-tissue suppression compared to GRE.DiscussionsZTE has low levels of acoustic noise, however, ZTE images had lower contrast near facial bones (e.g., zygomatic) and require effective bias-field correction to separate bone from air and soft-tissue. DURANDE utilizes a dual-echo subtraction post-processing approach to yield bone-specific images, but the sequence is not currently manufacturer-supported and requires scanner-specific gradient-delay corrections. Kamona, Nada; Jones, Brandon C.; Lee, Hyunyeol; Song, Hee Kwon; Rajapakse, Chamith S.; Wagner, Connor S.; Bartlett, Scott P.; Wehrli, Felix W. Univ Penn, Perelman Sch Med, Dept Radiol, Philadelphia, PA 19104 USA; Univ Penn, Dept Bioengn, Philadelphia, PA USA; Kyungpook Natl Univ, Sch Elect Engn, Daegu, South Korea; Univ Penn, Dept Orthopaed Surg, Philadelphia, PA USA; Childrens Hosp Philadelphia, Div Plast Reconstruct & Oral Surg, Philadelphia, PA USA ; Jones, Brandon/AAB-6130-2019 57208866181; 57209659335; 57193268117; 55663898800; 22635351400; 57222762859; 7202248305; 7007158575 Felix.Wehrli@pennmedicine.upenn.edu; MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE MAGN RESON MATER PHY 1352-8661 37 1 SCIE RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING 2024 2.5 38.4 3.74 2025-05-07 6 7 Cranial bone; UTE; ZTE; Black-bone MRI MAGNETIC-RESONANCE; RADIATION-EXPOSURE; CORTICAL BONE; CT; RECONSTRUCTION; SEGMENTATION; REDUCTION; DIAGNOSIS; SEQUENCE Black-bone MRI; Cranial bone; UTE; ZTE Adult; Child; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Skull; adult; child; diagnostic imaging; human; image processing; nuclear magnetic resonance imaging; procedures; skull English 2024 2024-02 10.1007/s10334-023-01125-8 바로가기 바로가기 바로가기 바로가기
Article Dysphagia associated with esophageal wall thickening in patients with nonspecific high-resolution manometry findings: Understanding motility beyond the Chicago classification version 4.0 BackgroundPrevious studies have demonstrated that 50% of patients with normal high-resolution manometry (HRM) findings or ineffective esophageal motility (IEM) may have abnormal functional luminal imaging probe (FLIP) results. However, the specific HRM findings associated with abnormal FLIP results are unknown. Herein, we investigated the relationship between nonspecific manometry findings and abnormal FLIP results.MethodsWe retrospectively analyzed 684 patients who underwent HRM at a tertiary care center in Seoul, Korea, based on the Chicago Classification version 4.0 protocol.Key ResultsAmong the 684 patients, 398 had normal HRM findings or IEM. Of these 398 patients, eight showed esophageal wall thickening on endoscopic ultrasonography or computed tomography; however, no abnormalities were seen during esophagogastroduodenoscopy. Among these eight patients, seven showed repetitive simultaneous contractions (RSCs) in at least one of the two positions: 61% (+/- 29%) in 10 swallows in the supine position and 51% (+/- 30%) in five swallows in the upright position. Four patients who underwent FLIP had a significantly decreased esophagogastric junction distensibility index (1.0 +/- 0.5 mm2mmHg-1$$ \mathrm{m}{\mathrm{m}}2{\mathrm{m}\mathrm{mHg}}{-1} $$ at 60 mL). Two of these patients underwent per-oral endoscopic myotomy (POEM) due to a lack of response to medication. Esophageal muscle biopsy revealed hypertrophic muscle with marginal eosinophil infiltration.Conclusions & InferencesA subset of patients (2%) with normal HRM findings or IEM and RSCs experienced dysphagia associated with poor distensibility of the thickened esophageal wall. FLIP assessment or combined HRM and impedance protocols may help better define these patients who may respond well to POEM. A subset of patients (2%) with normal manometry or ineffective esophageal motility and esophageal wall thickening showed distinctive repetitive pattern on manometry and poor distensibility index on FLIP. FLIP assessment or combined manometry and impedance protocols may help define these patients who may respond to per-oral endoscopic myotomy.image Choi, Jin Young; Jung, Kee Wook; Pandolfino, John E.; Choi, Kyungmin; Park, Young Soo; Na, Hee Kyong; Ahn, Ji Yong; Lee, Jeong Hoon; Kim, Do Hoon; Choi, Kee Don; Song, Ho June; Lee, Gin Hyug; Jung, Hwoon-yong Kyungpook Natl Univ Hosp, Dept Gastroenterol, Daegu, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Gastroenterol, 88 Olymp Ro 43 Gil, Seoul 05505, South Korea; Northwestern Univ, Feinberg Sch Med, Dept Med, Chicago, IL USA; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Biomed Engn, Seoul, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Pathol, Seoul, South Korea ; Ahn, Ji Yong/AGO-1695-2022; Lee, Hyuk-Joon/J-2782-2012 58814654500; 8551021400; 6603899097; 57216417556; 59135056800; 55385943800; 36809017800; 57219957826; 58750755200; 14621577200; 15051078900; 7404851852; 7403029804 jung.keewook30@gmail.com; NEUROGASTROENTEROLOGY AND MOTILITY NEUROGASTROENT MOTIL 1350-1925 1365-2982 36 4 SCIE CLINICAL NEUROLOGY;GASTROENTEROLOGY & HEPATOLOGY;NEUROSCIENCES 2024 2.9 38.4 1.7 2025-05-07 4 4 dysphagia; esophageal motility disorder; esophageal wall thickening; functional luminal imaging probe; manometry IRRITABLE-BOWEL-SYNDROME; ANTERIOR CINGULATE CORTEX; CORTICOTROPIN-RELEASING-FACTOR; VISCERAL HYPERSENSITIVITY; PEPPERMINT OIL; MENTHOL; STRESS; PAIN; MODULATION; ACTIVATION dysphagia; esophageal motility disorder; esophageal wall thickening; functional luminal imaging probe; manometry Deglutition Disorders; Esophageal Motility Disorders; Humans; Manometry; Retrospective Studies; adult; Article; clinical protocol; computer assisted tomography; controlled study; disease association; dysphagia; endoscopic ultrasonography; eosinophilia; esophageal contractility; esophagogastroduodenoscopy; esophagus biopsy; esophagus epithelium; esophagus manometry; esophagus motility; esophagus muscle; female; gastroesophageal junction; human; human tissue; major clinical study; male; middle aged; muscle hypertrophy; myotomy; retrospective study; South Korea; standing; supine position; swallowing; tertiary care center; complication; dysphagia; esophagus function disorder; manometry; pathology; procedures English 2024 2024-04 10.1111/nmo.14736 바로가기 바로가기 바로가기 바로가기
Article Evaluation of advective solute infiltration into porous media by pulsed focused ultrasound-induced acoustic streaming effects Purpose: Acoustic streaming induced by applying transcranial focused ultrasound (FUS) promotes localized advective solute transport in the brain and has recently garnered research interest for drug delivery and enhancement of brain waste clearance. The acoustic streaming behavior in brain tissue is difficult to model numerically and thus warrants an in vitro examination of the effects of using different sonication parameters, in terms of frequency, intensity, and pulse duration (PD). Methods: Melamine and polyvinyl alcohol (PVA) foams were used to mimic the porous brain tissue, which contains leptomeningeal fenestrations and perivascular space, while agar hydrogel was used to emulate denser neuropil. FUS was delivered to these media, which were immersed in a phosphate-buffered saline containing toluidine blue O dye, across various frequencies (400, 500, and 600 kHz; applicable to transcranial delivery) in a pulsed mode at two different spatial-peak pulse-average intensities (3 and 4 W/cm2). Results: Image analysis showed that the use of 400 kHz yielded the greatest dye infiltration in melamine foam, while sonication had no impact on infiltration in the agar hydrogel due to the dominance of diffusional transport. Using a fixed spatial-peak temporal-average intensity of 0.4 W/cm2 at 400 kHz, a PD of 75 ms resulted in the greatest infiltration depth in both melamine and PVA foams among the tested range (50-150 ms). Conclusion: These findings suggest the existence of a specific frequency and PD that induce greater enhancement of solute/fluid movement, which may contribute to eventual in vivo applications in promoting waste clearance from the brain. Van Reet, Jared; Tunnell, Kate; Anderson, Kara; Kim, Hyun-Chul; Kim, Evgenii; Kowsari, Kavin; Yoo, Seung-Schik Harvard Med Sch, Brigham & Womens Hosp, Dept Radiol, Boston, MA USA; Kyungpook Natl Univ, Dept Artificial Intelligence, Daegu, South Korea; Harvard Med Sch, Brigham & Womens Hosp, Dept Radiol, 75 Francis St, Boston, MA 02115 USA 57823770600; 58798377000; 58797835800; 57194876917; 59845978800; 55943178100; 7401970708 yoo@bwh.harvard.edu; ULTRASONOGRAPHY ULTRASONOGRAPHY 2288-5919 2288-5943 43 1 SCIE RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING 2024 2.5 38.4 0 2025-04-16 0 0 Radiation force; Bulk flow; Phantom; Alzheimer's disease; Glymphatic TECHNOLOGY Alzheimer’s disease; Bulk flow; Glymphatic; Phantom; Radiation force agar; desiccant; hydrogel; melamine; polyvinyl alcohol; porous media; tolonium chloride; unclassified drug; acoustic streaming effect; Alzheimer disease; Article; brain tissue; cytoarchitecture; drug delivery system; fenestration; foam; focused ultrasound therapy; glymphatic system; hydration; image analysis; in vitro study; microbubble; perivascular space; physiological process; pulse duration; radiation; solute; ultrasound English 2024 2024-01 10.14366/usg.23037 바로가기 바로가기 바로가기 바로가기
Article Financial information, spillovers, and innovation performance We hypothesize that high-quality financial information can, through its spillovers to peer firms' strategic decision-making, have an adverse effect on the disclosing firm's innovation performance. Using the degree of disaggregation in financial reports and patent-based measures to proxy for financial information quality and significance of innovative outputs, respectively, we find that the patented inventions of firms with more disaggregated financial reports are less innovative. We also document that the negative association is more pronounced for firms with more intense product market threats, a situation in which the spillover of more detailed information is costlier. We further validate our argument by documenting that disclosures of more and finer information actually help peers increase innovation activities and investments, consistent with the peers' effective strategic responses to the disclosing firm's innovation. Overall, the results from the cross-sectional analysis and validation tests confirm the channel through which more disaggregated financial information can lead to a decline in firm innovation performance. This study contributes to the literatures on information spillovers, economic consequences of financial reporting, proprietary costs of disclosures, and innovation. Kim, Jae B.; Kim, Jonghwan (Simon); Koo, KwangJoo Lehigh Univ, Coll Business, Lehigh, PA 18015 USA; Yonsei Univ, Sch Business, Seoul, South Korea; Kyungpook Natl Univ, Coll Econ & Business Adm, Daegu, South Korea 57189367818; 57216931696; 57202687309 jbk317@lehigh.edu;jonghwan.kim@yonsei.ac.kr;kjkoo@knu.ac.kr; JOURNAL OF ACCOUNTING AND PUBLIC POLICY J ACCOUNT PUBLIC POL 0278-4254 1873-2070 45 SSCI BUSINESS, FINANCE;PUBLIC ADMINISTRATION 2024 2.2 38.4 0.61 2025-05-07 1 1 Information spillover; Financial information quality; Peer effect; Proprietary costs of information; Innovation TECHNOLOGICAL-INNOVATION; ACCOUNTING INFORMATION; CORPORATE DISCLOSURE; EARNINGS MANAGEMENT; RESOURCE-ALLOCATION; REPORTING QUALITY; PATENT CITATIONS; LEVEL; PROPRIETARY; INDICATORS Financial information quality; Information spillover; Innovation; Peer effect; Proprietary costs of information English 2024 2024 (MAY-JUN) 10.1016/j.jaccpubpol.2024.107212 바로가기 바로가기 바로가기 바로가기
Review Hemodynamics in Doppler ultrasonography The cardiovascular system operates through complex hemodynamic processes involving pulsatile blood flow, varying viscosity, and the branching architecture of vessels. Interactions between blood flow and the vascular wall, which are characterized by shear and normal stress, along with wall stiffness, are crucial for maintaining vascular health. Doppler ultrasonography is a highly valuable noninvasive tool for assessing these hemodynamic parameters, enabling the measurement of key indices such as blood flow velocity, flow patterns, wall shear stress, and wall stiffness. This paper emphasizes the clinical significance of these indices and methods of measuring them using Doppler ultrasonography while addressing potential challenges. Accurate interpretation of these measurements is vital for reliable cardiovascular diagnostics and effective clinical decision-making. Lee, Jongmin Kyungpook Natl Univ, Sch Med, Dept Radiol, 680 Gukchaebosang Ro, Daegu 41944, South Korea 55689919700 jonglee@knu.ac.kr; ULTRASONOGRAPHY ULTRASONOGRAPHY 2288-5919 2288-5943 43 6 SCIE RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING 2024 2.5 38.4 0 2025-05-07 0 0 Doppler ultrasonography; Hemodynamic index; Vascular wall stress; Wall stiffness WALL SHEAR-STRESS; DUPLEX ULTRASOUND; PRESSURE-GRADIENT; ARTERY STENOSIS; BLOOD VELOCITY; CAROTID-ARTERY; WAVE-FORMS; FLOW; STIFFNESS; RHEOLOGY Doppler ultrasonography; Hemodynamic index; Vascular wall stress; Wall stiffness adult; blood flow; blood flow velocity; blood vessel wall; clinical decision making; complication; controlled study; diagnosis; Doppler ultrasonography; female; hemodynamic parameters; hemodynamics; human; review; rigidity; shear stress; ultrasound; vascularization; viscosity; wall stress English 2024 2024-11 10.14366/usg.24126 바로가기 바로가기 바로가기 바로가기
Article Ultrasound-guided ethanol ablation versus the Sistrunk operation as a primary treatment for thyroglossal duct cysts Purpose: This study compared ethanol ablation (EA) with the Sistrunk operation (SO) with regard to feasibility, treatment efficacy, and cost-effectiveness. The goal was to evaluate whether EA could replace SO as a primary treatment modality for thyroglossal duct cysts (TGDCs). Methods: This retrospective case-control study included patients with TGDCs who were treated with either EA or SO between 2016 and 2022. The primary outcome variables evaluated were treatment efficacy (as measured by the volume reduction rate [VRR] and treatment success rate), complications, and cost-effectiveness. Results: A total of 72 patients were enrolled, with 33 in the EA group and 39 in the SO group. The procedure or operation times for the EA and SO groups were 9 and 82 minutes, respectively (P<0.001). At the final follow-up appointment, the VRR was 94.1% for the EA group and 100.0% for the SO group (P<0.001). Treatment success was achieved for 32 patients (97.0%) in the EA group and for all 39 patients (100.0%) in the SO group (P= 0.458). The overall complication rates were 0.0% and 17.9% in the EA and SO groups, respectively (P=0.013). The total costs, including all treatment procedures and follow- up ultrasound examinations, were $485 and $1,081.7 for the EA and SO groups, respectively (P<0.001). Conclusion: EA demonstrates superiority over SO in terms of feasibility, safety, and cost-effectiveness, while maintaining comparable treatment efficacy. Despite the need for multiple treatment sessions in approximately one-quarter of patients, EA can serve as a primary treatment modality for selected patients with TGDCs, supplanting SO. Ahn, Dongbin; Kwak, Ji Hye; Lee, Gil Joon; Sohn, Jin Ho Kyungpook Natl Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, 130 Dongdeok Ro, Daegu 41944, South Korea 44761055400; 57393330600; 57193082568; 55165818100 godlikeu@naver.com; ULTRASONOGRAPHY ULTRASONOGRAPHY 2288-5919 2288-5943 43 1 SCIE RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING 2024 2.5 38.4 0 2025-04-16 0 0 Thyroglossal duct cyst; Ethanol ablation; Sistrunk operation; Comparison; Cost THYROID CYSTS; EFFICACY; SCLEROTHERAPY; INJECTION; NODULES Comparison; Cost; Ethanol ablation; Sistrunk operation; Thyroglossal duct cyst alcohol; adult; Article; case control study; Charlson Comorbidity Index; clinical decision making; cohort analysis; comparative study; computer assisted tomography; controlled study; cost effectiveness analysis; dysphagia; female; fine needle aspiration biopsy; follow up; hematoma; human; hyoid bone; infection; keloid; length of stay; major clinical study; male; middle aged; nerve injury; operation duration; physical examination; recurrent infection; retrospective study; seroma; sistrunk operation; skin fistula; skin flap; skin necrosis; surgical approach; thyroglossal duct cyst; ultrasound guided ethanol ablation; ultrasound therapy; viscosity; wound infection English 2024 2024-01 10.14366/usg.23128 바로가기 바로가기 바로가기 바로가기
Article Development of a cerebellar ataxia diagnosis model using conditional GAN-based synthetic data generation for visuomotor adaptation task This study proposes a synthetic data generation model to create a classification framework for cerebellar ataxia patients using trajectory data from the visuomotor adaptation task. The classification objectives include patients with cerebellar ataxia, age-matched normal individuals, and young healthy subjects. Synthetic data for the three classes is generated based on class conditions and random noise by leveraging a combination of conditional adversarial generative neural networks and reconstruction networks. This synthetic data, alongside real data, is utilized as training data for the patient classification model to enhance classification accuracy. The fidelity of the synthetic data is assessed visually to measure the validity and diversity of the generated data qualitatively while quantitatively evaluating distribution similarity to real data. Furthermore, the clinical efficacy of the patient classification model employing synthetic data is demonstrated by showcasing improved classification accuracy through a comparative analysis between results obtained using solely real data and those obtained when both real and synthetic data are utilized. This methodological approach holds promise in addressing data insufficiency in the digital healthcare domain, employing deep learning methodologies, and developing early disease diagnosis tools. Kim, Jinah; Woo, Sung-Ho; Kim, Taekyung; Yoon, Won Tae; Shin, Jung Hwan; Lee, Jee-Young; Ryu, Jeh-Kwang Korea Inst Ocean Sci & Technol, Coastal Disaster Res Ctr, Busan 49111, South Korea; Dongguk Univ, Coll Med, Inst Interdisciplinary Brain Sci, Goyang 10444, South Korea; Kyungpook Natl Univ, Sch Comp Sci & Engn, Daegu 41566, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Kangbuk Hosp, Dept Neurol, Seoul 03181, South Korea; Seoul Natl Univ, Coll Med, Dept Neurol, Seoul Natl Univ Hosp, Seoul 03080, South Korea; Seoul Natl Univ, Seoul Metropolitan Govt Seoul Natl Univ, Boramae Med Ctr, Dept Neurol,Coll Med, Seoul 07061, South Korea; Dongguk Univ, Convergence Res Ctr Artificial Intelligence, Lab Nat & Artificial Kinasthese, Seoul 04620, South Korea Shin, Jung/V-9220-2019; Ryu, Jeh-Kwang/HRD-3229-2023 55720345100; 57957841800; 59471665700; 13204609700; 57200396056; 36062860800; 57014059000 wieber04@snu.ac.kr;ryujk@dgu.ac.kr; BMC MEDICAL INFORMATICS AND DECISION MAKING BMC MED INFORM DECIS 1472-6947 24 1 SCIE MEDICAL INFORMATICS 2024 3.8 38.5 0 2025-05-07 0 1 Cerebellar ataxia diagnosis; Visuomotor adaptation task; Conditional generative adversarial network; Synthetic data; Digital healthcare INVOLVEMENT; PERFORMANCE; SCALE; MOTOR Cerebellar ataxia diagnosis; Conditional generative adversarial network; Digital healthcare; Synthetic data; Visuomotor adaptation task Adaptation, Physiological; Adult; Cerebellar Ataxia; Deep Learning; Female; Humans; Male; Middle Aged; Neural Networks, Computer; Psychomotor Performance; adult; artificial neural network; cerebellar ataxia; deep learning; diagnosis; female; human; male; middle aged; physiological adaptation; physiology; psychomotor performance English 2024 2024-11-12 10.1186/s12911-024-02720-y 바로가기 바로가기 바로가기 바로가기
Article Machine learning models for predicting the onset of chronic kidney disease after surgery in patients with renal cell carcinoma BackgroundPatients with renal cell carcinoma (RCC) have an elevated risk of chronic kidney disease (CKD) following nephrectomy. Therefore, continuous monitoring and subsequent interventions are necessary. It is recommended to evaluate renal function postoperatively. Therefore, a tool to predict CKD onset is essential for postoperative follow-up and management.MethodsWe constructed a cohort using data from eight tertiary hospitals from the Korean Renal Cell Carcinoma (KORCC) database. A dataset of 4389 patients with RCC was constructed for analysis from the collected data. Nine machine learning (ML) models were used to classify the occurrence and nonoccurrence of CKD after surgery. The final model was selected based on the area under the receiver operating characteristic (AUROC), and the importance of the variables constituting the model was confirmed using the shapley additive explanation (SHAP) value and Kaplan-Meier survival analyses.ResultsThe gradient boost algorithm was the most effective among the various ML models tested. The gradient boost model demonstrated superior performance with an AUROC of 0.826. The SHAP value confirmed that preoperative eGFR, albumin level, and tumor size had a significant impact on the occurrence of CKD after surgery.ConclusionsWe developed a model to predict CKD onset after surgery in patients with RCC. This predictive model is a quantitative approach to evaluate post-surgical CKD risk in patients with RCC, facilitating improved prognosis through personalized postoperative care. Oh, Seol Whan; Byun, Seok-Soo; Kim, Jung Kwon; Jeong, Chang Wook; Kwak, Cheol; Hwang, Eu Chang; Kang, Seok Ho; Chung, Jinsoo; Kim, Yong-June; Ha, Yun-Sok; Hong, Sung-Hoo Catholic Univ Korea, Coll Med, Dept Med Informat, Seoul 06591, South Korea; Catholic Univ Korea, Dept Biomed & Hlth Sci, Seoul 06591, South Korea; Seoul Natl Univ, Coll Med, Dept Urol, Bundang Hosp, Seongnam 13620, South Korea; Seoul Natl Univ, Seoul Natl Univ Hosp, Dept Urol, Coll Med, Seoul 03080, South Korea; Chonnam Natl Univ, Med Sch, Dept Urol, Gwangju 61469, South Korea; Korea Univ, Sch Med, Dept Urol, Seoul 02841, South Korea; Natl Canc Ctr, Dept Urol, Goyang 10408, South Korea; Chungbuk Natl Univ, Coll Med, Dept Urol, Cheongju 28644, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Urol, Daegu 41404, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Urol, Seoul, South Korea Kim, Yong-June/E-5622-2012; Hwang, Eu/K-3680-2019; Kwak, Cheol/J-2731-2012 57374338500; 7004818488; 58757961300; 8879131000; 7005639032; 8441681300; 7405684686; 16678454900; 26422204800; 35487226400; 37030299600 toomey@catholic.ac.kr; BMC MEDICAL INFORMATICS AND DECISION MAKING BMC MED INFORM DECIS 1472-6947 24 1 SCIE MEDICAL INFORMATICS 2024 3.8 38.5 1.61 2025-05-07 5 6 Renal cell carcinoma; Machine learning; Chronic kidney disease; KOrean Renal Cell Carcinoma; Gradient boost RADICAL NEPHRECTOMY; RISK-FACTORS; CLASSIFICATION; MANAGEMENT; SELECTION; OUTCOMES; RCC Chronic kidney disease; Gradient boost; KOrean Renal Cell Carcinoma; Machine learning; Renal cell carcinoma Carcinoma, Renal Cell; Glomerular Filtration Rate; Humans; Kidney Neoplasms; Nephrectomy; Renal Insufficiency, Chronic; Retrospective Studies; chronic kidney failure; glomerulus filtration rate; human; kidney tumor; nephrectomy; pathology; renal cell carcinoma; retrospective study English 2024 2024-03-22 10.1186/s12911-024-02473-8 바로가기 바로가기 바로가기 바로가기
Article Bidirectional Optical Neural Networks Based on Free-Space Optics Using Lens Arrays and Spatial Light Modulator This paper introduces a novel architecture-bidirectional optical neural network (BONN)-for providing backward connections alongside forward connections in artificial neural networks (ANNs). BONN incorporates laser diodes and photodiodes and exploits the properties of K & ouml;hler illumination to establish optical channels for backward directions. Thus, it has bidirectional functionality that is crucial for algorithms such as the backpropagation algorithm. BONN has a scaling limit of 96 x 96 for input and output arrays, and a throughput of 8.5 x 1015 MAC/s. While BONN's throughput may rise with additional layers for continuous input, limitations emerge in the backpropagation algorithm, as its throughput does not scale with layer count. The successful BONN-based implementation of the backpropagation algorithm requires the development of a fast spatial light modulator to accommodate frequent data flow changes. A two-mirror-like BONN and its cascaded extension are alternatives for multilayer emulation, and they help save hardware space and increase the parallel throughput for inference. An investigation into the application of the clustering technique to BONN revealed its potential to help overcome scaling limits and to provide full interconnections for backward directions between doubled input and output ports. BONN's bidirectional nature holds promise for enhancing supervised learning in ANNs and increasing hardware compactness. Ju, Young-Gu Kyungpook Natl Univ, Dept Phys Educ, 80 Daehak Ro, Daegu 41566, South Korea 7202809560 ygju@knu.ac.kr; MICROMACHINES MICROMACHINES-BASEL 2072-666X 15 6 SCIE CHEMISTRY, ANALYTICAL;INSTRUMENTS & INSTRUMENTATION;NANOSCIENCE & NANOTECHNOLOGY;PHYSICS, APPLIED 2024 3 38.6 0.7 2025-05-07 2 2 optical neural network; optical computer; backpropagation; neural network; lens array; free-space optics BACKPROPAGATION; MODEL backpropagation; free-space optics; lens array; neural network; optical computer; optical neural network Computer hardware; Lenses; Light modulation; Light modulators; Optical signal processing; Freespace optics; Input and outputs; Lens array; Network-based; Neural-networks; Novel architecture; Optical computers; Optical neural networks; Scaling limits; Spatial light modulators; Neural networks English 2024 2024-06 10.3390/mi15060701 바로가기 바로가기 바로가기 바로가기
Review Growing Trend to Adopt Speckle Variance Optical Coherence Tomography for Biological Tissue Assessments in Pre-Clinical Applications Speckle patterns are a generic feature in coherent imaging techniques like optical coherence tomography (OCT). Although speckles are granular like noise texture, which degrades the image, they carry information that can be benefited by processing and thereby furnishing crucial information of sample structures, which can serve to provide significant important structural details of samples in in vivo longitudinal pre-clinical monitoring and assessments. Since the motions of tissue molecules are indicated through speckle patterns, speckle variance OCT (SV-OCT) can be well-utilized for quantitative assessments of speckle variance (SV) in biological tissues. SV-OCT has been acknowledged as a promising method for mapping microvasculature in transverse-directional blood vessels with high resolution in micrometers in both the transverse and depth directions. The fundamental scope of this article reviews the state-of-the-art and clinical benefits of SV-OCT to assess biological tissues for pre-clinical applications. In particular, focus on precise quantifications of in vivo vascular response, therapy assessments, and real-time temporal vascular effects of SV-OCT are primarily emphasized. Finally, SV-OCT-incorporating pre-clinical techniques with high potential are presented for future biomedical applications. Wijesinghe, Ruchire Eranga; Kahatapitiya, Nipun Shantha; Lee, Changho; Han, Sangyeob; Kim, Shinheon; Saleah, Sm Abu; Seong, Daewoon; Silva, Bhagya Nathali; Wijenayake, Udaya; Ravichandran, Naresh Kumar; Jeon, Mansik; Kim, Jeehyun Sri Lanka Inst Informat Technol, Fac Engn, Dept Elect & Elect Engn, Malabe 10115, Sri Lanka; Sri Lanka Inst Informat Technol, Ctr Excellence Intelligent Informat Elect & Transm, Malabe 10115, Sri Lanka; Univ Sri Jayewardenepura, Fac Engn, Dept Comp Engn, Nugegoda 10250, Sri Lanka; Chonnam Natl Univ, Dept Artificial Intelligence Convergence, Gwangju 61186, South Korea; Chonnam Natl Univ, Med Sch, Dept Nucl Med, 264 Seoyang Ro, Hwasun 58128, South Korea; Hwasun Hosp, 264,Seoyang ro, Hwasun 58128, South Korea; Kyungpook Natl Univ, ICT Convergence Res Ctr, 80 Daehak Ro, Daegu 41566, South Korea; Kyungpook Natl Univ, Coll IT Engn, Sch Elect & Elect Engn, 80 Daehak Ro, Daegu 41566, South Korea; Sri Lanka Inst Informat Technol, Fac Comp, Malabe 10115, Sri Lanka; Korea Basic Sci Inst, Ctr Sci Instrumentat, 169-148 Gwahak Ro, Daejeon 34133, South Korea ; Wijenayake, Udaya/AAY-8146-2021; RAVICHANDRAN, NARESH KUMAR/D-2190-2017; Han, Sangyeob/W-3206-2018; Wijesinghe, Ruchire/K-3797-2016; Kahatapitiya, Nipun Shantha/IYJ-5055-2023; Silva, Bhagya/AAW-1014-2021 56018152300; 58781581100; 56198394900; 57193695305; 57226603736; 57218499446; 57212512353; 57192304387; 55547801900; 57125825900; 24171094000; 7601373350 eranga.w@sliit.lk;egt18538@sjp.ac.lk;udayaw@sjp.ac.lk;nareshr9169@kbsi.re.kr;msjeon@knu.ac.kr; MICROMACHINES MICROMACHINES-BASEL 2072-666X 15 5 SCIE CHEMISTRY, ANALYTICAL;INSTRUMENTS & INSTRUMENTATION;NANOSCIENCE & NANOTECHNOLOGY;PHYSICS, APPLIED 2024 3 38.6 0.91 2025-05-07 2 6 speckle-variance optical coherence tomography (SV-OCT); biological tissue imaging; microvasculature mapping; pre-clinical monitoring; blood flow assessment; in vivo vascular assessment HIGH-SPEED; FOCUSED ULTRASOUND; REFRACTIVE-INDEX; FLOW MEASUREMENT; THERAPY; MICROVASCULATURE; PRINCIPLES; VASCULATURE; GENERATION; MICROSCOPY biological tissue imaging; blood flow assessment; in vivo vascular assessment; microvasculature mapping; pre-clinical monitoring; speckle-variance optical coherence tomography (SV-OCT) Blood; Blood vessels; Histology; Medical applications; Optical tomography; Speckle; Textures; Tissue; Biological tissue imaging; Biological tissues; Blood flow; Blood flow assessment; Clinical monitoring; In vivo vascular assessment; In-vivo; Micro-vasculature; Microvasculature mapping; Pre-clinical; Pre-clinical monitoring; Speckle variances; Speckle-variance optical coherence tomography; Tissue imaging; Mapping English 2024 2024-05 10.3390/mi15050564 바로가기 바로가기 바로가기 바로가기
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