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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Letter | Reply: Response to Clinical Outcomes of Solid Organ Transplant Recipients Hospitalized with COVID-19: A Propensity Score-Matched Cohort Study | Nam, Eunkyung; Lim, Jeong-Hoon; Kwon, Ki Tae | Kyungpook Natl Univ, Sch Med, Dept Internal Med, Div Infect Dis,Chilgok Hosp, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Div Nephrol,Chilgok Hosp, Daegu, South Korea | Lim, Jeong-Hoon/ABE-6003-2020; Hwang, Soyoon/HHM-5762-2022 | 58121908200; 55360244300; 9733850500 | ktkwon@knu.ac.kr; | INFECTION AND CHEMOTHERAPY | INFECT CHEMOTHER | 2093-2340 | 2092-6448 | 56 | 3 | ESCI | INFECTIOUS DISEASES | 2024 | 2.9 | 37.6 | 0 | 2025-05-07 | 0 | 0 | mycophenolate mofetil; age; clinical outcome; coronavirus disease 2019; depression; disease severity; graft recipient; hospital patient; human; immunocompromised patient; immunosuppressive treatment; Letter; long COVID; lung transplantation; organ transplantation; propensity score; risk factor; treatment protocol; vaccination | English | 2024 | 2024-09 | 10.3947/ic.2024.0076 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Roadmap for providing and leveraging annotated data by cytologists in the PDAC domain as open data: support for AI-based pathology image analysis development and data utilization strategies | Pancreatic cancer is one of the most lethal cancers worldwide, with a 5-year survival rate of less than 5%, the lowest of all cancer types. Pancreatic ductal adenocarcinoma (PDAC) is the most common and aggressive pancreatic cancer and has been classified as a health emergency in the past few decades. The histopathological diagnosis and prognosis evaluation of PDAC is time-consuming, laborious, and challenging in current clinical practice conditions. Pathological artificial intelligence (AI) research has been actively conducted lately. However, accessing medical data is challenging; the amount of open pathology data is small, and the absence of open-annotation data drawn by medical staff makes it difficult to conduct pathology AI research. Here, we provide easily accessible high-quality annotation data to address the abovementioned obstacles. Data evaluation is performed by supervised learning using a deep convolutional neural network structure to segment 11 annotated PDAC histopathological whole slide images (WSIs) drawn by medical staff directly from an open WSI dataset. We visualized the segmentation results of the histopathological images with a Dice score of 73% on the WSIs, including PDAC areas, thus identifying areas important for PDAC diagnosis and demonstrating high data quality. Additionally, pathologists assisted by AI can significantly increase their work efficiency. The pathological AI guidelines we propose are effective in developing histopathological AI for PDAC and are significant in the clinical field. | Kim, Jongkwang; Bae, Sumok; Yoon, Seong-Mi; Jeong, Sungmoon | Kyungpook Natl Univ, Sch Med, Dept Med Informat, Daegu, South Korea; ORTHOTECH, Med Res Inst, Med Ctr, Dept Pathol, Daegu, South Korea | 59226639400; 59226639500; 59226478700; 23100090400 | jeongsm00@gmail.com; | FRONTIERS IN ONCOLOGY | FRONT ONCOL | 2234-943X | 14 | SCIE | ONCOLOGY | 2024 | 3.3 | 37.6 | 0.47 | 2025-05-07 | 1 | 1 | pancreatic ductal adenocarcinoma; deep convolutional neural network; whole slide image; histopathology; supervised learning; dice score; high quality | LONG-TERM SURVIVAL; PANCREATIC-CANCER; EPIDEMIOLOGY; RESECTION | deep convolutional neural network; dice score; high quality; histopathology; pancreatic ductal adenocarcinoma; supervised learning; whole slide image | algorithm; Article; artificial intelligence; cell biologist; convolutional neural network; deep learning; feature extraction; histopathology; human; human tissue; image analysis; image processing; image quality; image segmentation; learning algorithm; pancreas cancer; pancreatic ductal carcinoma; pathology; residual neural network | English | 2024 | 2024-07-05 | 10.3389/fonc.2024.1346237 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | TAZ is involved in breast cancer cell migration via regulating actin dynamics | Background: Cancer metastasis is dependent on cell migration. Several mechanisms, including epithelial-to-mesenchymal transition (EMT) and actin fiber formation, could be involved in cancer cell migration. As a downstream effector of the Hippo signaling pathway, transcriptional coactivator with PDZ-binding motif (TAZ) is recognized as a key mediator of the metastatic ability of breast cancer cells. We aimed to examine whether TAZ affects the migration of breast cancer cells through the regulation of EMT or actin cytoskeleton. Methods: MCF-7 and MDA-MB-231 cells were treated with siRNA to attenuate TAZ abundance. Transwell migration assay and scratch wound healing assay were performed to study the effects of TAZ knockdown on cancer cell migration. Fluorescence microscopy was conducted to examine the vinculin and phalloidin. Semiquantitative immunoblotting and quantitative real-time PCR were performed to study the expression of small GTPases and kinases. Changes in the expression of genes associated with cell migration were examined through next-generation sequencing. Results: TAZ-siRNA treatment reduced TAZ abundance in MCF-7 and MDA-MB-231 breast cancer cells, which was associated with a significant decrease in cell migration. TAZ knockdown increased the expression of fibronectin, but it did not exhibit the typical pattern of EMT progression. TGF-beta treatment in MDA-MB-231 cells resulted in a reduction in TAZ and an increase in fibronectin levels. However, it paradoxically promoted cell migration, suggesting that EMT is unlikely to be involved in the decreased migration of breast cancer cells in response to TAZ suppression. RhoA, a small Rho GTPase protein, was significantly reduced in response to TAZ knockdown. This caused a decrease in the expression of the Rho-dependent downstream pathway, i.e., LIM kinase 1 (LIMK1), phosphorylated LIMK1/2, and phosphorylated cofilin, leading to actin depolymerization. Furthermore, myosin light chain kinase (MLCK) and phosphorylated MLC2 were significantly decreased in MDA-MB-231 cells with TAZ knockdown, inhibiting the assembly of stress fibers and focal adhesions. Conclusion: TAZ knockdown inhibits the migration of breast cancer cells by regulating the intracellular actin cytoskeletal organization. This is achieved, in part, by reducing the abundance of RhoA and Rho-dependent downstream kinase proteins, which results in actin depolymerization and the disassembly of stress fibers and focal adhesions. | Choi, Hong Seok; Jang, Hyo-Ju; Kristensen, Mathilde K.; Kwon, Tae-Hwan | Kyungpook Natl Univ, Sch Med, Dept Biochem & Cell Biol, Taegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, KNU Convergence Educ Program BK21 4, Taegu, South Korea; Aarhus Univ, Fac Hlth, Med, Aarhus, Denmark | Kwon, Tae-Hwan/ABA-1981-2020 | 58072531000; 57214330719; 59135981700; 7202206089 | thkwon@knu.ac.kr; | FRONTIERS IN ONCOLOGY | FRONT ONCOL | 2234-943X | 14 | SCIE | ONCOLOGY | 2024 | 3.3 | 37.6 | 1.05 | 2025-04-16 | 3 | 3 | actin; breast cancer; cell migration; small GTPase; TAZ | EPITHELIAL-MESENCHYMAL TRANSITION; HIPPO SIGNALING PATHWAY; STRESS FIBERS; FOCAL ADHESIONS; METASTASIS; PHOSPHORYLATION; ORGANIZATION; CYTOSKELETON; AQUAPORIN-5; ACTIVATION | actin; breast cancer; cell migration; small GTPase; TAZ | actin; AMPA receptor; integrin; LIM kinase 1; myosin light chain; occludin; pdz binding motif; peptides and proteins; Rac1 protein; Rho guanine nucleotide binding protein; transcription factor Snail; unclassified drug; uvomorulin; vimentin; vinculin; antibody labeling; Article; breast cancer; cell invasion assay; cell migration; controlled study; cytoskeleton; epithelial mesenchymal transition; gene ontology; human; human cell; immunoblotting; MCF-7 cell line; MDA-MB-231 cell line; protein phosphorylation; real time polymerase chain reaction; signal transduction; wound healing assay | English | 2024 | 2024-05-07 | 10.3389/fonc.2024.1376831 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Updated Clinical Practice Guidelines for the Diagnosis and Management of Long COVID | "Long COVID" is a term used to describe a condition when the symptoms and signs associated with coronavirus disease 2019 (COVID-19) persist for more than three months among patients infected with COVID-19; this condition has been reported globally and poses a serious public health issue. Long COVID can manifest in various forms, highlighting the need for appropriate evaluation and management by experts from various fields. However, due to the lack of clear clinical definitions, knowledge of pathophysiology, diagnostic methods, and treatment protocols, it is necessary to develop the best standard clinical guidelines based on the scientific evidence reported to date. We developed this clinical guideline for diagnosing and treating long COVID by analyzing the latest research data collected from the start of the COVID-19 pandemic until June 2023, along with the consensus of expert opinions. This guideline provides recommendations for diagnosis and treatment that can be applied in clinical practice, based on a total of 32 key questions related to patients with long COVID. The evaluation of patients with long COVID should be comprehensive, including medical history, physical examination, blood tests, imaging studies, and functional tests. To reduce the risk of developing long COVID, vaccination and antiviral treatment during the acute phase are recommended. This guideline will be revised when there is a reasonable need for updates based on the availability of new knowledge on the diagnosis and treatment of long COVID. | Seo, Jun -Won; Kim, Seong Eun; Kim, Yoonjung; Kim, Eun Jung; Kim, Tark; Kim, Taehwa; Lee, So Hee; Lee, Eunjung; Lee, Jacob; Bin Seo, Yu; Jeong, Young-Hoon; Jung, Young Hee; Choi, Yu Jung; Song, Joon Young | Chosun Univ, Coll Med, Dept Internal Med, Div Infect Dis, Gwangju, South Korea; Chonnam Natl Univ, Med Sch, Dept Internal Med, Div Infect Dis, Gwangju, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Div Infect Dis, Dept Internal Med,Sch Med, Daegu, South Korea; Natl Assembly Res Serv, Hlth Welf Family & Gender Equal Team, Seoul, South Korea; Soonchunhyang Univ, Bucheon Hosp, Dept Internal Med, Div Infect Dis, Bucheon, South Korea; Pusan Natl Univ, Yangsan Hosp, Dept Internal Med, Div Pulmonol Allergy & Crit Care Med, Yangsan, South Korea; Natl Med Ctr, Dept Psychiat, Seoul, South Korea; Soonchunhyang Univ, Seoul Hosp, Dept Internal Med, Div Infect Dis,Coll Med, Seoul, South Korea; Hallym Univ, Kangnam Sacred Heart Hosp, Dept Internal Med, Div Infect Dis,Coll Med, Seoul, South Korea; Chung Ang Univ, Gwangmyeong Hosp, CAU Thrombosis & Biomarker Ctr, Seoul, South Korea; Hanyang Univ, Myongji Hosp, Coll Med, Dept Neurol, Goyang, South Korea; Korea Univ, Coll Med, Dept Internal Med, Div Infect Dis, Seoul, South Korea; Korea Univ, Guro Hosp, Dept Internal Med, Div Infect Dis,Coll Med, 148 Gurodong Ro, Seoul 08308, South Korea | ; Lee, So Hee/B-5940-2016; Kim, Sang-Ha/ACC-9085-2022; KIM, TARK/LNP-3907-2024; Kim, Jung/S-5543-2017; Jeong, Young-Hoon/F-3476-2015; Kim, Ik-Sang/J-5425-2012; Choi, Yu Jung/HOF-0843-2023; Kim, Tark/MFH-8178-2025 | 57189901863; 57226683401; 57203160508; 56898285100; 55501021000; 57043724300; 56442744300; 57203206523; 13406664300; 18538511000; 24758957500; 57192553880; 57914887600; 57214400146 | infection@korea.ac.kr; | INFECTION AND CHEMOTHERAPY | INFECT CHEMOTHER | 2093-2340 | 2092-6448 | 56 | 1 | ESCI | INFECTIOUS DISEASES | 2024 | 2.9 | 37.6 | 13.68 | 2025-05-07 | 22 | 26 | Long COVID; SARS-CoV-2; Post-COVID condition; Persistent symptoms; Management | SEQUELAE; COUGH; HOSPITALIZATION; PREVENTION; INFECTION; DYSPHAGIA; FATIGUE; ADULTS | Long COVID; Management; Persistent symptoms; Post-COVID condition; SARS-CoV-2 | antivirus agent; apixaban; betamethasone; fluvoxamine; prednisolone; rivaroxaban; antiviral therapy; anxiety disorder; Article; clinical feature; clinical practice guideline; clouding of consciousness; cognitive defect; depression; diagnostic imaging; Embase; evidence based practice; human; infection risk; long COVID; medical history; Medline; pathophysiology; physical examination; taste disorder; thrombosis; thrombosis prevention; treatment protocol | English | 2024 | 2024-03 | 10.3947/ic.2024.0024 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Amino acid ionic liquids as efficient catalysts for CO2 capture: A combined static and dynamic approach | Amino acid ionic liquids (AAILs) have gained significant attention as green solvents that are biocompatible, biodegradable, and useful in various applications, including catalysts, absorbents, and solvents. This study investigates the detailed interactions of three amino acid anions (glycine [Gly]-, histidine [His]-, and arginine [Arg]-) with the cation 1-methoxylbutyl-3-methylimidazolium [MOBMIM]+ and their role in CO2 absorption using quantum mechanical calculations and molecular dynamics (MD) simulations. The Density Functional Theory (DFT) calculations elucidate the reaction mechanisms underlying CO2 absorption and cycloaddition, and facilitate a comparative analysis of the impact of different amino acids on these reactions, and the synergies between them. Notably, arginine displays superior CO2 absorption capacity in comparison to glycine and histidine. Additionally, the cycloaddition reaction with CO2 exhibits a lower energy barrier when arginine is involved. Insights from the MD simulations highlight the higher level of electrostatic interaction between [MOBMIM]+[Arg]- and CO2, relative to the other studied molecules. Moreover, the Lennard Jones interaction emerges as the dominant type of interaction in these systems. The diffusion coefficient for CO2 was highest when interacting with [MOBMIM]+[Gly]-, followed by [MOBMIM]+[Arg]-. Consequently, both MD and DFT investigations converge to suggest that [MOBMIM]+[Arg]- followed by [MOBMIM]+[Gly]- may serve as advantageous choices for CO2 fixation and cycloaddition. The findings from this study underscore the considerable potential of the investigated AAILs as materials conducive to CO2 capture and utilization, thus paving the way for the integration of CO2 capture into valuable chemical products. | Shaikh, Abdul Rajjak; Vidal-Lopez, Anna; Brotons-Rufes, Artur; Pajski, Jason J.; Zafar, Sadain; Mahmood, Raisul Awal; Khan, Muhammad Usman; Poater, Albert; Chawla, Mohit; Cavallo, Luigi | STEMskills Res & Educ Lab Pvt Ltd, Dept Res & Innovat, Faridabad 121002, Haryana, India; Univ Girona, Inst Quim Computac & Catalisi, C Maria Aurelia Capmany 69, Girona 17003, Catalonia, Spain; Univ Girona, Dept Quim, C Maria Aurelia Capmany 69, Girona 17003, Catalonia, Spain; Univ Autonoma Barcelona, Dept Chem, Cerdanyola Del Valles 08193, Catalonia, Spain; East Carolina Univ, Dept Chem, Greenville, NC 27858 USA; Univ Lille, CERLA Ctr Etud & Rech Lasers & Applicat, CNRS, UMR 8523,PhLAM,Lab Phys Lasers Atomes & Mol, F-59000 Lille, France; Kyungpook Natl Univ, Dept Chem, Daegu, South Korea; Univ Okara, Dept Chem, Okara 56300, Pakistan; King Abdullah Univ Sci & Technol KAUST, KAUST Catalysis Ctr, Phys Sci & Engn Div, Thuwal 239556900, Saudi Arabia | Khan, Muhammad Usman Faryad/ADL-4196-2022; Xia, Chuan/S-7452-2019; Chawla, Mohit/R-1766-2019; Poater, Albert/D-6586-2013; Pajski, Jason/ABB-9318-2021; Vidal-Lopez, Anna/KSM-8087-2024; Shaikh, Abdul Rajjak/C-5624-2012 | 12241355200; 57739104600; 57222431822; 24172791700; 58778783200; 57786307300; 56132334300; 8533443400; 36726752600; 56465514800 | ab_rajjak@yahoo.co.in;albert.poater@udg.edu;mohit.chawla@kaust.edu.sa;luigi.cavallo@kaust.edu.sa; | RESULTS IN SURFACES AND INTERFACES | RESULTS SURF INTERF | 2666-8459 | 14 | ESCI | MATERIALS SCIENCE, MULTIDISCIPLINARY | 2024 | 4.4 | 37.7 | 2.95 | 2025-05-07 | 9 | 11 | Ionic liquid; Sustainable catalysis; Molecular dynamics; DFT calculations; CO2 | ABSORPTION; POLYMERIZATION; MECHANISM; VISCOSITY | CO<sub>2</sub>; DFT calculations; Ionic liquid; Molecular dynamics; Sustainable catalysis | English | 2024 | 2024-02-01 | 10.1016/j.rsurfi.2023.100175 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Characteristics of high-repetition-rate bipolar pulse DBD under various electrical conditions in atmospheric-pressure air | Numerous studies have been conducted on pulse dielectric barrier discharge (DBD) because it can produce powerful discharges uniformly at atmospheric pressure with a fast rise time. Although much research has been conducted on pulse DBD below 10 kHz, relatively little has been conducted on pulse DBD at high pulse repetition rates (PRRs). Therefore, in this study, the ozone generation and discharge characteristics of bipolar pulse DBD in atmospheric-pressure air at a high PRR of 10 kHz or above were investigated. According to the results of this study, with the exception of electron temperature, most discharge characteristics need for practical applications-like transfer charge, electron density, and discharge uniformity-improved as the voltage and duty ratio increased at high PRR. On the contrary, increasing the PRR exhibited trade-off features like low electron temperature, low discharge uniformity, and a high number of discharges per unit time. Ozone generation demonstrated good results at high voltage, appropriate PRR, and low duty ratio, but applying suitable electrical conditions is crucial considering ozone generation speed and power consumption. The findings of this study will be very beneficial for high-PRR pulse DBD applications that require quick and effective processing. Additionally, they will be useful for researching the characteristics of pulse DBD at high PRR. | Kim, Seong-Hun; Yun, Ung-Hui; Kim, Jin-Gyu | Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Elect & Elect Engn, Dept Elect Engn, Daegu 41566, South Korea | 58464715100; 57295722800; 54680957000 | kjg@knu.ac.kr; | JOURNAL OF PHYSICS D-APPLIED PHYSICS | J PHYS D APPL PHYS | 0022-3727 | 1361-6463 | 57 | 12 | SCIE | PHYSICS, APPLIED | 2024 | 3.2 | 37.7 | 0.38 | 2025-05-07 | 2 | 1 | high-repetition-rate; pulse DBD; ozone; atmospheric pressure; air | DIELECTRIC BARRIER DISCHARGE; PLASMA REACTOR; GENERATION; FREQUENCY; UNIPOLAR; PHYSICS; VOLTAGE | air; atmospheric pressure; high-repetition-rate; ozone; pulse DBD | Atmospheric pressure; Dielectric devices; Dielectric materials; Economic and social effects; Electron temperature; Ozone; Pulse repetition rate; Atmospheric-pressure airs; Bipolar pulse; Condition; Dielectric barrier discharges; Discharge characteristics; Discharge uniformities; High pulse repetition rate; High repetition rate; Ozone generation; Pulse dielectric barrier discharge; Dielectric barrier discharge | English | 2024 | 2024-03-22 | 10.1088/1361-6463/ad172a | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Demonstration of Threshold Switching in Undoped SiOX Layer for Oscillation Neurons | The function of artificial oscillation neurons (ONs) has been emulated using threshold switching (TS) properties. Thus far, the TS behavior of SiOx materials has been demonstrated by incorporating toxic elements (e.g., As or Te). This study demonstrates TS using a toxic element-free undoped SiOx layer sandwiched by Nb electrodes. We identify that the TS in the SiOx is related to instantly clustered oxygen vacancies ( V-0 ) through comparative studies with NbO2 -based TS devices and Nb/SiOx interface analyses. The transition from memory switching to nonlinear behavior via the abrupt TS with respect to the Ar/O gas ratio during SiOx deposition further indicates the significance of the amount of V-0 . Transient analysis of TS devices shows both volatile output current for triangular pulses and reproducible voltage oscillation for square pulses. The achieved oscillation response is tuned using an input voltage and load resistor; thus, the SiO x -based TS can serve as the ON. Hence, we demonstrate the recognition of 3 x 5 alphabetic patterns in oscillatory neural networks (ONNs) comprising 15 SiOx -based TSs through MATLAB simulations. | Hong, Eunryeong; Kim, Hyun Wook; Choi, Hyeonsik; Jeon, Seonuk; Kim, Nayeon; Woo, Jiyong | Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea | 57556070800; 57557016000; 58835686900; 57955098300; 59884547500; 53985749100 | jiyong.woo@knu.ac.kr; | IEEE TRANSACTIONS ON ELECTRON DEVICES | IEEE T ELECTRON DEV | 0018-9383 | 1557-9646 | 71 | 3 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC;PHYSICS, APPLIED | 2024 | 3.2 | 37.7 | 1.02 | 2025-05-07 | 3 | 3 | Oscillation neuron (ON); oscillatory neural network (ONN); SiOX; threshold switching (TS) | MEMORY | Oscillation neuron (ON); oscillatory neural network (ONN); SiO; threshold switching (TS) | Behavioral research; Computer circuits; Neurons; Silicon compounds; Switching circuits; Threshold voltage; Timing circuits; > <tex-math notation="LaTeX">$_{\textit{x}}$</tex-math> </inline-formula>; Behavioral science; Oscillation neuron; Oscillatory neural network; Oscillatory neural networks; SiO<inline-formula xmlns:ali="; Sputtering; Threshold switching; Xmlns:mml="; Xmlns:xlink="; Xmlns:xsi="; Electrodes | English | 2024 | 2024-03 | 10.1109/ted.2024.3350550 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Dual Ferroelectric Stack of HfZrO2 /Al:HfO2 With Tunable Coercive Voltage for High-Density Memory Applications | To achieve a multilevel threshold voltage in the configuration of a ferroelectric field-effect transistor for high-density memories, it is crucial to achieve a finely tunable coercive voltage ( V-C) of the ferroelectric layer (FL). In this study, we demonstrate that the use of dual ferroelectric stacks with Zr-doped HfO2 (HZO) and Al-doped HfO2 (HAO) allows the adjustment of V-C and remnant polarization (P-r) over a broad range relative to the ramping voltage. When a single HZO FL is used, a rapid increase in P-r is observed, reaching approximately 30 mu C/cm(2) at a specific VC value. In contrast, the HAO FL progresses at a slower rate, achieving a smaller P-r value approximately equal to 7 mu C/cm(2) with increasing voltage. In the dual-stack configuration, polarization occurs sequentially through each FL, enabling the incremental adjustment of V-C . The stress primarily arises after the deposition of the top electrode during annealing, thus emphasizing the crucial role of the upper FL in the ferroelectric properties of the dual stack. Furthermore, our findings reveal that substituting a dielectric layer (DL)for the HAO FL, rather than the HZO FL, exacerbates polarization, revealing that the synergistic effect originates from two different FLs. | Jeong, Jiae; Park, Hyoungjin; Kim, Nayeon; Kim, Hyun Wook; Hong, Eunryeong; Choi, Hyeonsik; Jeon, Seonuk; Kim, Yunsur; Woo, Jiyong | Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea | 58963433800; 58964076600; 59884547500; 57557016000; 57556070800; 58835686900; 57955098300; 58847712800; 53985749100 | jiyong.woo@knu.ac.kr; | IEEE TRANSACTIONS ON ELECTRON DEVICES | IEEE T ELECTRON DEV | 0018-9383 | 1557-9646 | 71 | 6 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC;PHYSICS, APPLIED | 2024 | 3.2 | 37.7 | 0.34 | 2025-05-07 | 1 | 1 | Hafnium oxide; Annealing; FeFETs; Electrodes; Dielectrics; Temperature measurement; Stress; Al:HFO2; dual ferroelectric stack; ferroelectric memory; HfZrO2 | Al:HFO<sub>2</sub>; dual ferroelectric stack; ferroelectric memory; HfZrO<sub>2</sub> | Aluminum compounds; Ferroelectric materials; Ferroelectricity; Field effect transistors; Hafnium oxides; Zirconium compounds; > <tex-math notation="LaTeX">$_{\text{2}}$</tex-math> </inline-formula>; Al:HFO<inline-formula xmlns:ali="; Dual ferroelectric stack; Ferroelectric memory; HfZrO<inline-formula xmlns:ali="; Xmlns:mml="; Xmlns:xlink="; Xmlns:xsi="; Threshold voltage | English | 2024 | 2024-06 | 10.1109/ted.2024.3387884 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Linear Synaptic Weight Update in Selector-Less HfO2 RRAM Using Al2O3 Built-In Resistor for Neuromorphic Computing Systems | The engineering filament evolution of HfO2-based resistive random access memory (RRAM) has shown promising advancements in analog synaptic weight updates during the training stage for neuromorphic systems. However, the significance of incorporating an additional selector to eliminate sneak-path currents has often been neglected. Therefore, this study addresses this issue by demonstrating linearly and symmetrically tuned synaptic weights in selector-less HfO2-based RRAM. By introducing an extremely thin Al2O3 layer in the HfO2 RRAM, we observed a nonlinear current-voltage behavior that effectively suppresses low-resistance states in the low-voltage regime, which act as sneak-path currents. Through simple numerical fitting, we determined that the Al2O3 layer functions as a built-in exponential resistor, and we investigated the impact of its thickness on the switching behavior. To further understand the role of the Al2O3 layer, we analyzed the set-switching mechanism of the selector-less RRAM by examining the real-time transient current response. Unlike an abrupt current jump typically observed in conventional RRAMs, we observed a sequential transition in the selector-less RRAM. This implies that conduction in the selector-less RRAM is in two steps through each oxide of the Al2O3/HfO2 stack. Therefore, the utilization of the Al2O3 both enables analogously modulated current response through an identical pulse scheme for the selected cell and suppresses unwanted updates of half-selected cells. The improved linearity of synaptic weight updates in the selector-less Al2O3 /HfO2 RRAM allows for high pattern recognition accuracy on the MNIST dataset, based on the backpropagation algorithm performed in IBM AIHWKIT simulations. | Kim, Yunsur; Kim, Hyejin; Jeon, Seonuk; Kim, Hyun Wook; Hong, Eunryeong; Kim, Nayeon; Choi, Hyeonsik; Park, Hyoungjin; Jeong, Jiae; Lee, Daeseok; Woo, Jiyong | Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea; Kwangwoon Univ, Dept Elect Mat Engn, Seoul 01897, South Korea | 58847712800; 57558641700; 57955098300; 57557016000; 57556070800; 59884547500; 58835686900; 58964076600; 58963433800; 36604679100; 53985749100 | jiyong.woo@knu.ac.kr; | IEEE TRANSACTIONS ON ELECTRON DEVICES | IEEE T ELECTRON DEV | 0018-9383 | 1557-9646 | 71 | 8 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC;PHYSICS, APPLIED | 2024 | 3.2 | 37.7 | 0 | 2025-04-16 | 0 | 1 | Neuromorphic computing; resistive random access memory (RRAM); selector-less RRAM; synaptic behavior | CROSSBAR ARRAYS; DEVICE; MEMORY; MECHANISM; SYNAPSES; NETWORK | Neuromorphic computing; resistive random access memory (RRAM); selector-less RRAM; synaptic behavior | Aluminum; Hafnium oxides; Personnel training; Resistors; Accuracy; Neuromorphic computing; Random access memory; Resistance; Resistive random access memory; Selector-less resistive random access memory; Synaptic behavior; Synaptic weight; Weight update; RRAM | English | 2024 | 2024-08 | 10.1109/ted.2024.3408784 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Article | Understanding Switching Mechanism of Selector-Only Memory Using Se-Based Ovonic Threshold Switch Device | In this study, we investigated the effect of material composition on the selector-only memory (SOM) characteristics of ovonic threshold switch (OTS) device. By controlling the selenium (Se) concentration within the chalcogenide film, we were able to optimize the electrical properties. OTS devices co-sputtered with Se exhibited excellent characteristics, including a sufficient memory window (MW > 1.2 V) and fast operation speed ( similar to 10 ns). Furthermore, we found that the desired MW could be obtained by varying the pulse height during the write process. The optical bandgap and bond nature of chalcogenide film were analyzed by UV-vis and Raman spectroscopy, revealing that the Se is the key element to the SOM operation of the OTS device. To understand the correlation between electrical properties and modification of the bond topology, we employed density functional theory (DFT) calculations. Finally, we explained the mechanism of SOM operation by introducing a thermally assisted hopping (TAH) model and analyzing the trap behavior in OTS devices. From our experimental results, we have demonstrated that the stability of delocalized traps formed depending on the polarity of the write pulse plays a crucial role in the operation of the SOM device. Our findings provide valuable insights into the complex relationship between material composition and the electrical characteristics of SOM devices. | Lee, Jangseop; Seo, Yoori; Ban, Sanghyun; Kim, Dong Gwan; Park, Yu Bin; Lee, Tae Hoon; Hwang, Hyunsang | Pohang Univ Sci & Technol POSTECH, Ctr Single Atom Based Semicond Device, Dept Mat Sci & Engn, Pohang 790784, South Korea; Kyungpook Natl Univ, Sch Mat Sci & Engn, Daegu 702701, South Korea | Ban, Sanghyun/JDN-0699-2023; Lee, Tae/B-1160-2013; Lee, Jangseop/LZF-9463-2025 | jangsub@postech.ac.kr;hwanghs@postech.ac.kr; | IEEE TRANSACTIONS ON ELECTRON DEVICES | IEEE T ELECTRON DEV | 0018-9383 | 1557-9646 | 71 | 5 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC;PHYSICS, APPLIED | 2024 | 3.2 | 37.7 | 9 | Optical switches; Chalcogenides; Photonic band gap; Nonhomogeneous media; Voltage measurement; Topology; Threshold voltage; Cross-point array (XPA); ovonic threshold switch (OTS); selector-only memory (SOM); thermally assisted hopping (TAH) model; threshold voltage | English | 2024 | 2024-05 | 10.1109/ted.2024.3378221 | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | ○ | Article | Anuria after kidney transplantation diagnosed as early recurrence of focal segmental glomerulosclerosis combined with acute calcineurin inhibitor nephrotoxicity: a case report and literature review | Background Primary focal segmental glomerulosclerosis (FSGS) is a glomerular disease that sometimes recurs in patients after kidney transplantation (KT) and increases the risk of graft loss. Proteinuria is a common early sign of recurrent FSGS, but an abrupt decrease in urine volume is rare. Herein, we report a patient with early recurrence of FSGS with anuria following KT.Case presentation A 55-year-old man with end-stage kidney disease caused by primary FSGS experienced anuria on postoperative day 2 following deceased donor KT. Laboratory results revealed that serum tacrolimus trough levels were consistently elevated at the time of anuria. At first, we considered acute calcineurin inhibitor (CNI) nephrotoxicity based on graft biopsy on light microscopy, laboratory findings, and clinical courses. However, the allograft function did not recover even after discontinuation of CNI, and recurrent FSGS was diagnosed 2 weeks later on electron microscopy. A total of 13 sessions of plasmapheresis and two administrations of rituximab (375 mg/m2) were required to treat recurrent FSGS. The patient achieved a partial response, and the spot urine protein-to-creatinine ratio decreased from 15.5 g/g creatinine to 5.2 g/g creatinine. At 5 months following KT, the serum creatinine level was stable at 1.15 mg/dL.Conclusions These findings highlight that anuria can occur in cases of early recurrence of FSGS combined with acute CNI nephrotoxicity. | Kim, Yoon-Ju; Lee, Seong-Wook; Kim, Mee-Seon; Kim, Yong-Jin; Choi, Ji-Young; Cho, Jang-Hee; Kim, Chan-Duck; Kim, Yong-Lim; Yun, Woo-Sung; Huh, Seung; Lim, Jeong-Hoon; Park, Sun-Hee | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Div Nephrol,Dept Internal Med, 130 Dongdeok Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Pathol, 130 Dongdeok Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Surg, 130 Dongdeok Ro, Daegu 41944, South Korea | Park, Sun-Hee/LMN-0033-2024; Cho, Jang-hee/ABD-3534-2020; Kim, Yong-Lim/AGK-3172-2022; Lim, Jeong-Hoon/ABE-6003-2020; Kim, Yong-Jin/J-2745-2012 | 58978545400; 58844486200; 56123006700; 56150365500; 7501393222; 7403536291; 8558530700; 55633533600; 35070717000; 7101832929; 55360244300; 7501831741 | jh-lim@knu.ac.kr;sh-park@knu.ac.kr; | BMC NEPHROLOGY | BMC NEPHROL | 1471-2369 | 25 | 1 | SCIE | UROLOGY & NEPHROLOGY | 2024 | 2.4 | 38.0 | 1.14 | 2025-05-07 | 2 | 2 | Anuria; Calcineurin inhibitor toxicity; Focal segmental glomerulosclerosis; Kidney transplantation; Proteinuria | Anuria; Calcineurin inhibitor toxicity; Focal segmental glomerulosclerosis; Kidney transplantation; Proteinuria | Anuria; Calcineurin Inhibitors; Creatinine; Glomerulosclerosis, Focal Segmental; Humans; Kidney Diseases; Kidney Transplantation; Male; Middle Aged; Recurrence; basiliximab; corticosteroid; creatinine; cyclophosphamide; cyclosporine; methylprednisolone; mycophenolic acid; pentetic acid; rituximab; tacrolimus; thymocyte antibody; calcineurin inhibitor; creatinine; adult; anuria; Article; case report; clinical article; creatinine blood level; deceased donor; Doppler flowmetry; drug blood level; drug dose reduction; drug response; drug withdrawal; electron microscopy; end stage renal disease; focal glomerulosclerosis; hematuria; hemodialysis; human; human tissue; immunosuppressive treatment; kidney biopsy; kidney perfusion; kidney transplantation; laboratory test; leg edema; male; microscopy; middle aged; nephrotoxicity; plasmapheresis; postoperative period; protein creatinine ratio; proteinuria; recurrent disease; remission; urinalysis; urine volume; anuria; focal glomerulosclerosis; kidney disease; procedures; recurrent disease | English | 2024 | 2024-04-05 | 10.1186/s12882-024-03524-y | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Fibronectin glomerulopathy in an elderly patient with FN1 gene mutation: a case report and literature review | BackgroundFibronectin glomerulopathy (FNG) is a rare autosomal dominant glomerulopathy that can lead to nephrotic syndrome. Here we report the case of an elderly patient diagnosed with FNG, exhibiting nephrotic-range proteinuria, with a 2-year follow-up.Case presentationA 75-year-old Korean female visited the nephrology clinic after experiencing generalized edema for 2 months. Her serum creatinine was 1.36 mg/dL, and urine protein-to-creatinine ratio was 3.99 g/g. Kidney biopsy revealed mesangial and subendothelial dense deposits, and immunohistochemistry for fibronectin showed strong positivity in the glomerulus. The patient's family history included non-specific renal disease in her mother and two siblings. Genetic testing of the fibronectin 1 (FN1) gene showed Y973C mutation. She received conservative treatment, including angiotensin II receptor blockers (ARB). Two years after biopsy, the patient has preserved renal function and reduced proteinuria.ConclusionWe report the case of a 75-year-old patient with nephrotic-range proteinuria, who was diagnosed with FNG, and found to harbor a FN1 gene mutation. In this case, conservative treatment including ARB yielded reduction of proteinuria and preservation of renal function. | Choi, Ji-Young; Kim, Mee-Seon; Kim, Zehwan | Kyungpook Natl Univ, Sch Med, Dept Internal Med, Div Nephrol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pathol, Daegu, South Korea; Yeungnam Univ, Dept Lab Med, Coll Med, 170 Hyeonchung Ro, Daegu 42415, South Korea | 7501393222; 59510682600; 57226085449 | ogkim@hotmail.com; | BMC NEPHROLOGY | BMC NEPHROL | 1471-2369 | 25 | 1 | SCIE | UROLOGY & NEPHROLOGY | 2024 | 2.4 | 38.0 | 0.57 | 2025-05-07 | 1 | 1 | Fibronectin; Nephrotic syndrome; FN1; Glomerulopathy with Fibronectin Deposit; Elderly | FAMILIAL GLOMERULOPATHY; DEPOSITS | Elderly; Fibronectin; FN1; Glomerulopathy with Fibronectin Deposit; Nephrotic syndrome | Aged; Female; Fibronectins; Glomerulonephritis, Membranoproliferative; Glomerulopathy with fibronectin deposits; Humans; Mutation; Proteinuria; amlodipine besylate; angiotensin receptor antagonist; antistreptolysin; azilsartan; fibronectin; fibronectin 1; hemoglobin; torasemide; unclassified drug; fibronectin; FN1 protein, human; aged; Article; case report; clinical article; conservative treatment; creatinine blood level; electron microscopy; estimated glomerular filtration rate; female; fibronectin glomerulopathy; fn1 gene; follow up; gene; gene mutation; generalized edema; genetic screening; glomerulopathy; glomerulus; hematuria; histology; human; human tissue; immunofluorescence; immunohistochemistry; kidney biopsy; kidney function; leukocyte count; platelet count; polymerase chain reaction; protein creatinine ratio; protein urine level; proteinuria; urea nitrogen blood level; urinalysis; y973c gene; genetics; membranoproliferative glomerulonephritis; mutation; pathology | English | 2024 | 2024-09-16 | 10.1186/s12882-024-03752-2 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Flexible endoscope manipulating robot using quad-roller friction mechanism | A robotic system for manipulating a flexible endoscope in surgery can provide enhanced accuracy and usability compared to manual operation. However, previous studies require large-scale, complex hardware systems to implement the rotational and translational motions of the soft endoscope cable. The conventional control of the endoscope by actuating the endoscope handle also leads to undesired slack between the endoscope tip and the handle, which becomes more problematic with long endoscopes such as a colonoscope. This study proposes a compact quad-roller friction mechanism that enables rotational and translational motions triggered not from the endoscope handle but at the endoscope tip. Controlling two pairs of tilted rollers achieves both types of motion within a small space. The proposed system also introduces an unsynchronized motion strategy between the handle and tip parts to minimize the robot's motion near the patient by employing the slack positively as a control index. Experiments indicate that the proposed system achieves accurate rotational and translational motions, and the unsynchronized control method reduces the total translational motion by up to 88% compared to the previous method. | Lee, Subin; Kim, Hyeonwook; Byeon, Jaehyeon; Shim, Seongbo; Lee, Hyun-Joo; Hong, Jaesung | Daegu Gyeongbuk Inst Sci & Technol DGIST, Dept Robot & Mechatron Engn, Daegu, South Korea; Ajinextek, Dev Team 3, Cheongju, South Korea; Korea Inst Machinery & Mat KIMM, Dept Med Robot, Daejeon, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp KNU, Sch Med, Dept Orthopaed Surg, Daegu, South Korea | Lee, Hyun Joo/GVU-6347-2022 | 58074061500; 57225125058; 59338644700; 57113042000; 58838750100; 55825553700 | jhong@dgist.ac.kr; | COMPUTER ASSISTED SURGERY | COMPUT ASSIST SURG | 2469-9322 | 29 | 1 | SCIE | SURGERY | 2024 | 1.9 | 38.0 | 0 | 2025-05-07 | 0 | 0 | Flexible endoscope; medical robots and systems; friction mechanism; quad-roller system | SYSTEM | Flexible endoscope; friction mechanism; medical robots and systems; quad-roller system | Endoscopes; Equipment Design; Friction; Humans; Robotic Surgical Procedures; Robotics; devices; endoscope; equipment design; friction; human; procedures; robot assisted surgery; robotics | English | 2024 | 2024-12-31 | 10.1080/24699322.2024.2404695 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Optimal sequential therapy using tyrosine kinase inhibitors as the first-line treatment in patients with metastatic renal cell carcinoma: A nationwide multicenter study | Objective: The purpose of the study was to identify the best sequence of therapy beginning with a tyrosine kinase inhibitor (TKI) as the first-line therapy for patients with metastatic renal cell carcinoma (mRCC) in terms of overall survival (OS), progression-free survival (PFS), and rates of discontinuation and adverse effects during the treatment period. Methods: This is a retrospective, nationwide multicenter study of patients with mRCC after diagnosis at 10 different tertiary medical centers in Korea from January 1992 to December 2017. We focused on patients at either "favorable" or "intermediate" risk according to the International mRCC Database Consortium criteria, and they were followed up (median 335 days). Finally, a total of 1409 patients were selected as the study population. We generated a Cox proportional hazard model adjusted for covariates, and the different therapy schemes were statistically tested in terms of OS as well as PFS. In addition, frequencies of discontinuation and adverse events were compared among the therapy schemes. Results: Of the primary patterns of treatment sequences (24 sequences), "sunitinib-pazopanib" and "sunitinib-everolimus-immunotherapy" showed the most beneficial results in both OS and PFS with significantly lower hazards than "sunitinib", which is the most commonly treated agent in Korea. Considering that the "TKI-TKI" structure showed relatively higher discontinuation rates with higher adverse effects, the overall beneficial sequence would be "sunitinib-everolimus-immunotherapy". Conclusion: Among several sequential therapy starting with TKIs, "sunitinib-everolimusimmunotherapy" was found to be the best scheme for mRCC patients with "favorable" or "intermediate" risks. 2024 Editorial Office of Asian Journal of Urology. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/). | Jo, Jung Ki; Kang, Minyong; Chung, Jinsoo; Kwak, Cheol; Hong, Sung-Hoo; Song, Cheryn; Park, Jae Young; Jeong, Chang Wook; Choi, Seok Hwan; Kim, Sung Han; Hwang, Eu Chang; Lee, Chan Ho; Lee, Hakmin | Hanyang Univ, Coll Med, Dept Urol Med & Digital Engn, Seoul, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Urol, Seoul, South Korea; Natl Canc Ctr, Dept Urol, Goyang, South Korea; Seoul Natl Univ Hosp, Dept Urol, Seoul, South Korea; Kangnam St Marys Hosp, Dept Urol, Seoul, South Korea; Asan Med Ctr, Dept Urol, Seoul, South Korea; Korea Univ, Ansan Hosp, Dept Urol, Ansan, South Korea; Kyungpook Natl Univ Hosp, Dept Urol, Daegu, South Korea; Chonnam Natl Univ, Hwasun Hosp, Dept Urol, Hwasun 519763, South Korea; Inje Univ, Busan Paik Hosp, Dept Urol, Pusan 614735, South Korea; Seoul Natl Univ, Bundang Hosp, Dept Urol, Seongnam, South Korea | Kwak, Cheol/J-2731-2012; Park, Jae Young/AFQ-0813-2022; Hwang, Eu/K-3680-2019; Park, Jae young/AFQ-0813-2022 | 37060991000; 7202469835; 23489077600; 16678454900; 7005639032; 37030299600; 10040623600; 55717166600; 8879131000; 59285654000; 57201923804; 48661004300; 55855972900; 59528247200 | victorjo38@hanyang.ac.kr; | ASIAN JOURNAL OF UROLOGY | ASIAN J UROL | 2214-3882 | 2214-3890 | 11 | 3 | ESCI | UROLOGY & NEPHROLOGY | 2024 | 2.4 | 38.0 | 0 | 2025-05-07 | 0 | 0 | Tyrosine kinase inhibitor; Metastatic renal cell carcinoma; Overall survival; Progression-free survival | TARGETED THERAPY; SURVIVAL | Metastatic renal cell carcinoma; Overall survival; Progression-free survival; Tyrosine kinase inhibitor | everolimus; hemoglobin; mammalian target of rapamycin; pazopanib; protein tyrosine kinase inhibitor; sorafenib; sunitinib; adult; aged; Article; Asian; chemotherapy; clinical feature; ex-smoker; female; first-line treatment; human; immunotherapy; lymphocyte; major clinical study; male; metastatic renal cell carcinoma; monotherapy; neutrophil; non-smoker; overall survival; progression free survival; retrospective study; risk factor | English | 2024 | 2024-07 | 10.1016/j.ajur.2022.11.004 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Significance of intrarenal vascular lesions in Ig A nephropathy prognosis | BackgroundImmunoglobulin A nephropathy (IgAN) is the predominant primary glomerulonephritis globally and remains a subject of active research with a focus on understanding its course and prognosis. Although vascular lesions are associated with IgAN, the current histopathological grading systems do not consider intrarenal vascular lesions when predicting patient prognosis. Therefore, this retrospective study conducted at Kyungpook National University Hospital between October 2016 and December 2021, aimed to elucidate the significance of intrarenal vascular lesions in IgAN by comparing the clinical data of patients with and without such lesions.MethodsData of patients with biopsy-confirmed primary IgAN between October 2016 and June 2021 at Kyungpook National University Hospital (Daegu, South Korea) were collected, and their medical records were reviewed. All slides from these 138 cases were independently pathologically reviewed by two nephropathologists (Y. J. K. and M. S. K.) using light microscope. The vascular lesions included in this study were fibrous intimal thickening, arteriolar wall thickening, and arteriolar hyalinosis. All cases were reviewed according to the Oxford Classification of IgA Nephropathy (2016) and Haas classification.ResultsOf the 138 patients, 88 exhibited at least one intrarenal vascular lesion. Patients with arteriolar wall thickening demonstrated a reduced estimated glomerular filtration rate (eGFR), elevated serum creatinine level and urine protein-to-creatinine ratio, an increased proportion of global glomerulosclerosis, and a higher histologic grade of interstitial fibrosis and tubular atrophy at the time of biopsy.ConclusionArteriolar wall thickening in IgAN are associated with reduced eGFR and global glomerulosclerosis. Moreover, reduced eGFR and global glomerulosclerosis are correlated with the progression to end-stage renal disease. Although the direct correlation between vascular lesions and end-stage renal disease is not entirely clear, a marginally significant association (log-rank test, p = 0.06) was observed with arterial wall thickening. This study suggests the potential importance of vascular lesions in the prognosis of IgAN, encouraging further investigation using larger cohort studies to establish a clearer association. | Yang, Hyeon Tae; Park, Tae In; Kim, Yong-Jin; Kim, Mee-seon; Park, Sun-Hee; Lim, Jeong-Hoon; Kang, Yoo Na; Kim, Dongja; Han, Man-Hoon | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Pathol, Daegu 41944, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Dent, Dept Pathol, Daegu 41944, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med,Div Nephrol, Daegu 41944, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Forens Med, Daegu 41944, South Korea | Park, Sun-Hee/LMN-0033-2024; Kim, Yong-Jin/ADJ-6184-2022; Lim, Jeong-Hoon/ABE-6003-2020 | 58170330200; 7401801814; 56150365500; 59510682600; 7501831741; 55360244300; 59369810300; 57282881600; 57194067936 | manhun0125@gmail.com; | BMC NEPHROLOGY | BMC NEPHROL | 1471-2369 | 25 | 1 | SCIE | UROLOGY & NEPHROLOGY | 2024 | 2.4 | 38.0 | 0 | 2025-05-07 | 0 | 0 | Immunoglobulin a nephropathy; IgA nephropathy; IgA; Prognosis; Intrarenal vascular lesion; Glomerular filtration rate; Oxford; Haas | OXFORD CLASSIFICATION; ARTERIAL LESIONS; VALIDATION | Glomerular filtration rate; Haas; IgA; IgA nephropathy; Immunoglobulin a nephropathy; Intrarenal vascular lesion; Oxford; Prognosis | Adult; Arterioles; Female; Glomerular Filtration Rate; Glomerulonephritis, IGA; Humans; Kidney; Male; Middle Aged; Prognosis; Retrospective Studies; albumin; creatinine; hemoglobin; uric acid; adult; aged; arterial wall thickening; Article; cholesterol blood level; diastolic blood pressure; end stage renal disease; estimated glomerular filtration rate; female; fibrosing alveolitis; glomerulosclerosis; human; human tissue; hypertension; immunoglobulin A nephropathy; intrarenal vascular lesion; kidney disease; major clinical study; male; platelet count; prognosis; protein creatinine ratio; renin angiotensin aldosterone system; retrospective study; survival analysis; systolic blood pressure; urea nitrogen blood level; arteriole; glomerulus filtration rate; kidney; middle aged; pathology; prognosis; vascularization | English | 2024 | 2024-10-16 | 10.1186/s12882-024-03803-8 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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